MS4A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.99504833
2acrosome reaction (GO:0007340)9.56431195
3binding of sperm to zona pellucida (GO:0007339)9.50541513
4cell-cell recognition (GO:0009988)9.49321870
5spermatid nucleus differentiation (GO:0007289)9.18235352
6axonemal dynein complex assembly (GO:0070286)8.87671544
7motile cilium assembly (GO:0044458)8.61819251
8spermatid development (GO:0007286)8.60602646
9sexual reproduction (GO:0019953)8.16646904
10cilium movement (GO:0003341)8.07649981
11cilium or flagellum-dependent cell motility (GO:0001539)7.65528731
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.30746172
13single fertilization (GO:0007338)7.13986223
14sperm capacitation (GO:0048240)7.08895378
15response to pheromone (GO:0019236)7.06581525
16single strand break repair (GO:0000012)6.69289951
17synaptonemal complex assembly (GO:0007130)6.26341657
18synaptonemal complex organization (GO:0070193)6.08921374
19male meiosis (GO:0007140)5.94489013
20protein K11-linked deubiquitination (GO:0035871)5.84042765
21branching involved in prostate gland morphogenesis (GO:0060442)5.78733381
22fertilization (GO:0009566)5.63911000
23negative regulation of inclusion body assembly (GO:0090084)5.43600532
24regulation of cilium movement (GO:0003352)5.38687671
25organic cation transport (GO:0015695)5.31620583
26spermatogenesis (GO:0007283)5.21293558
27tachykinin receptor signaling pathway (GO:0007217)5.19062645
28male gamete generation (GO:0048232)5.18823211
29glycerol ether metabolic process (GO:0006662)5.13906719
30calcium ion-dependent exocytosis (GO:0017156)5.12023926
31gamete generation (GO:0007276)4.76027738
32ether metabolic process (GO:0018904)4.72722871
33cell recognition (GO:0008037)4.54011133
34regulation of inclusion body assembly (GO:0090083)4.53506052
35germ cell development (GO:0007281)4.50621241
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.45412169
37microtubule depolymerization (GO:0007019)4.40595367
38regulation of meiosis I (GO:0060631)4.39671543
39piRNA metabolic process (GO:0034587)4.32167364
40monoubiquitinated protein deubiquitination (GO:0035520)4.28242355
41chromosome organization involved in meiosis (GO:0070192)4.08277856
42protein polyglutamylation (GO:0018095)3.98642613
43base-excision repair, AP site formation (GO:0006285)3.88461256
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.86896537
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.86896537
46ventricular system development (GO:0021591)3.79722767
47multicellular organismal reproductive process (GO:0048609)3.77763477
48microtubule severing (GO:0051013)3.70434025
49retinal cone cell development (GO:0046549)3.67799474
50artery development (GO:0060840)3.64985147
51prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.63451595
52prostate gland epithelium morphogenesis (GO:0060740)3.62352846
53response to nitrosative stress (GO:0051409)3.62176878
54mismatch repair (GO:0006298)3.59613440
55nonmotile primary cilium assembly (GO:0035058)3.57928468
56cellular ketone body metabolic process (GO:0046950)3.56814425
57negative regulation of telomere maintenance (GO:0032205)3.55359336
58regulation of cytokine production involved in inflammatory response (GO:1900015)3.46544770
59negative regulation of meiosis (GO:0045835)3.42618284
60genitalia morphogenesis (GO:0035112)3.37619699
61gamma-aminobutyric acid transport (GO:0015812)3.36525606
62carnitine metabolic process (GO:0009437)3.32293912
63macroautophagy (GO:0016236)3.31920591
64cell redox homeostasis (GO:0045454)3.29185030
65mannosylation (GO:0097502)3.25643338
66seminiferous tubule development (GO:0072520)3.24905657
67peptidyl-threonine dephosphorylation (GO:0035970)3.23922678
68alkaloid metabolic process (GO:0009820)3.23263227
69C-terminal protein lipidation (GO:0006501)3.22722377
70meiotic nuclear division (GO:0007126)3.20460426
71chromatin silencing (GO:0006342)3.19045540
72axoneme assembly (GO:0035082)3.15309880
73C-terminal protein amino acid modification (GO:0018410)3.12673872
74ketone body metabolic process (GO:1902224)3.11775474
75positive regulation of oligodendrocyte differentiation (GO:0048714)3.11223034
76auditory receptor cell stereocilium organization (GO:0060088)3.11041235
77multicellular organismal development (GO:0007275)3.10597655
78rRNA catabolic process (GO:0016075)3.09487936
79pyrimidine nucleobase catabolic process (GO:0006208)3.02130278
80negative regulation of meiotic cell cycle (GO:0051447)3.00163543
81startle response (GO:0001964)2.99480651
82centriole assembly (GO:0098534)2.99144962
83photoreceptor cell maintenance (GO:0045494)2.97622648
84amino-acid betaine metabolic process (GO:0006577)2.96990728
85positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.96921979
86mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.96921979
87mitotic cell cycle arrest (GO:0071850)2.96411597
88positive regulation of mitochondrial fission (GO:0090141)2.96260015
89sequestering of actin monomers (GO:0042989)2.95961240
90regulation of microtubule-based movement (GO:0060632)2.95314253
91male meiosis I (GO:0007141)2.91671702
92positive regulation of steroid hormone secretion (GO:2000833)2.91619082
93DNA methylation involved in gamete generation (GO:0043046)2.89911955
94chromosome condensation (GO:0030261)2.89226187
95NAD biosynthetic process (GO:0009435)2.89082161
96nucleosome disassembly (GO:0006337)2.88624728
97protein-DNA complex disassembly (GO:0032986)2.88624728
98left/right pattern formation (GO:0060972)2.88540946
99photoreceptor cell development (GO:0042461)2.88370689
100maturation of 5.8S rRNA (GO:0000460)2.87745067
101preassembly of GPI anchor in ER membrane (GO:0016254)2.87495138
102water-soluble vitamin biosynthetic process (GO:0042364)2.86655374
103interferon-gamma secretion (GO:0072643)2.84415424
104behavioral response to nicotine (GO:0035095)2.84314967
105GPI anchor metabolic process (GO:0006505)2.82417481
106pharyngeal system development (GO:0060037)2.81454638
107reciprocal meiotic recombination (GO:0007131)2.81397523
108reciprocal DNA recombination (GO:0035825)2.81397523
109positive regulation of macrophage activation (GO:0043032)2.78519942
110epithelial cell maturation (GO:0002070)2.76511167
111iron-sulfur cluster assembly (GO:0016226)2.76466864
112metallo-sulfur cluster assembly (GO:0031163)2.76466864
113cerebral cortex radially oriented cell migration (GO:0021799)2.76102507
114negative regulation of JAK-STAT cascade (GO:0046426)2.74303123
115regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.73944372
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71570931
117ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.71561030
118glycine transport (GO:0015816)2.71030035
119nucleus organization (GO:0006997)2.69071408
120alditol metabolic process (GO:0019400)2.68659183
121hormone catabolic process (GO:0042447)2.68199040
122aggressive behavior (GO:0002118)2.67294666
123protein refolding (GO:0042026)2.66861603
124DNA damage induced protein phosphorylation (GO:0006975)2.66557857
125glycolytic process (GO:0006096)2.65675764
126response to testosterone (GO:0033574)2.64579021
127polyol catabolic process (GO:0046174)2.64427732
128prenylation (GO:0097354)2.63531303
129protein prenylation (GO:0018342)2.63531303
130tongue development (GO:0043586)2.62814148
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62716708
132nucleobase catabolic process (GO:0046113)2.62679708
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62234547
134DNA packaging (GO:0006323)2.59106608
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58828558
136inner ear receptor stereocilium organization (GO:0060122)2.57578768
137cilium morphogenesis (GO:0060271)2.56465395
138oxidative demethylation (GO:0070989)2.56390251
139L-fucose catabolic process (GO:0042355)2.56176999
140fucose catabolic process (GO:0019317)2.56176999
141L-fucose metabolic process (GO:0042354)2.56176999
142indolalkylamine metabolic process (GO:0006586)2.55676921
143behavioral response to ethanol (GO:0048149)2.55613317
144indolalkylamine catabolic process (GO:0046218)2.54469752
145tryptophan catabolic process (GO:0006569)2.54469752
146indole-containing compound catabolic process (GO:0042436)2.54469752
147nitric oxide mediated signal transduction (GO:0007263)2.54064181
148centriole replication (GO:0007099)2.54061321
149rRNA modification (GO:0000154)2.53649167
150neural tube formation (GO:0001841)2.51773034
151regulation of acrosome reaction (GO:0060046)2.51305035
152angiotensin maturation (GO:0002003)2.49759972
153protein K48-linked deubiquitination (GO:0071108)2.49230169
154positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.48319755
155detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48174597
156microtubule polymerization or depolymerization (GO:0031109)2.47953158
157platelet dense granule organization (GO:0060155)2.47562992
158postsynaptic membrane organization (GO:0001941)2.47212373
159adenosine metabolic process (GO:0046085)2.46781932
160DNA deamination (GO:0045006)2.46713897
161cilium organization (GO:0044782)2.46673150
162DNA demethylation (GO:0080111)2.46517781
163glycerol metabolic process (GO:0006071)2.45664774
164cilium assembly (GO:0042384)2.39808372
165mannose metabolic process (GO:0006013)2.38488782
166cellular component assembly involved in morphogenesis (GO:0010927)2.37231904
167lactate metabolic process (GO:0006089)2.35160708
168cell wall macromolecule metabolic process (GO:0044036)17.8088928
169cell wall macromolecule catabolic process (GO:0016998)17.8088928
170fusion of sperm to egg plasma membrane (GO:0007342)13.1514703
171sperm motility (GO:0030317)12.6473055
172acrosome assembly (GO:0001675)11.2448949
173multicellular organism reproduction (GO:0032504)11.2309584
174reproduction (GO:0000003)10.5499608
175sperm-egg recognition (GO:0035036)10.5493440
176epithelial cilium movement (GO:0003351)10.4804084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.96576188
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.51253818
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.60531226
4GBX2_23144817_ChIP-Seq_PC3_Human2.86824218
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.85666985
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.80438133
7IGF1R_20145208_ChIP-Seq_DFB_Human2.75665106
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73188165
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.71585824
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70697787
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65250188
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.62808534
13RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse2.47554007
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46262439
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39454051
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24483077
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.23677719
18FUS_26573619_Chip-Seq_HEK293_Human2.19083266
19KAP1_22055183_ChIP-Seq_ESCs_Mouse2.17937402
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.14472753
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03114687
22ER_23166858_ChIP-Seq_MCF-7_Human1.98657997
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95196252
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94031700
25P300_19829295_ChIP-Seq_ESCs_Human1.93745541
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89663637
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87783449
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.87591819
29* KDM2B_26808549_Chip-Seq_REH_Human1.87576629
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83652789
31IRF1_19129219_ChIP-ChIP_H3396_Human1.82112623
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.80571220
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.78940337
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76886451
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.75049203
36CMYC_18555785_Chip-Seq_ESCs_Mouse1.73668907
37TAL1_26923725_Chip-Seq_HPCs_Mouse1.72069561
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.70645306
39EWS_26573619_Chip-Seq_HEK293_Human1.70315691
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69925009
41ZNF274_21170338_ChIP-Seq_K562_Hela1.67423480
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.66654380
43EZH2_22144423_ChIP-Seq_EOC_Human1.65333296
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65056687
45P53_22387025_ChIP-Seq_ESCs_Mouse1.64808545
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63060123
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.61410014
48STAT1_17558387_ChIP-Seq_HELA_Human1.60661753
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.60317866
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60302336
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.60171383
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59148624
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58265850
54P300_18555785_Chip-Seq_ESCs_Mouse1.55248173
55BCAT_22108803_ChIP-Seq_LS180_Human1.48724018
56VDR_22108803_ChIP-Seq_LS180_Human1.48247705
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.47654421
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46262565
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45731078
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43636197
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40154161
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40154161
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.39619584
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39580378
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39519827
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.38660776
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37626346
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37413831
69VDR_23849224_ChIP-Seq_CD4+_Human1.36856469
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.36231062
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35481991
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.35470777
73NANOG_19829295_ChIP-Seq_ESCs_Human1.35427202
74SOX2_19829295_ChIP-Seq_ESCs_Human1.35427202
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35129866
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.33602638
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.33414750
78MYC_18940864_ChIP-ChIP_HL60_Human1.33022653
79AR_25329375_ChIP-Seq_VCAP_Human1.32933956
80TP53_22573176_ChIP-Seq_HFKS_Human1.31973038
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30898610
82STAT3_23295773_ChIP-Seq_U87_Human1.30566082
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30376141
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.29329785
85ESET_19884257_ChIP-Seq_ESCs_Mouse1.29180064
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.27510044
87CBP_20019798_ChIP-Seq_JUKART_Human1.27155549
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27155549
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26488747
90TCF4_23295773_ChIP-Seq_U87_Human1.25892886
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25510008
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25443370
93NCOR_22424771_ChIP-Seq_293T_Human1.23343080
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22796296
95SMAD4_21799915_ChIP-Seq_A2780_Human1.22277987
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.21686015
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.21326487
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21038380
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20142791
100AR_21572438_ChIP-Seq_LNCaP_Human1.18667743
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.18337900
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17707621
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17473779
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17156380
105P53_21459846_ChIP-Seq_SAOS-2_Human1.17030043
106PU1_27457419_Chip-Seq_LIVER_Mouse1.16193371
107GATA3_21867929_ChIP-Seq_CD8_Mouse1.16162589
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.15943446
109WDR5_24793694_ChIP-Seq_LNCAP_Human1.15593111
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15136029
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15121725
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14881470
113EST1_17652178_ChIP-ChIP_JURKAT_Human1.14101714
114NMYC_18555785_Chip-Seq_ESCs_Mouse1.13369040
115CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12949754
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.12838820
117HOXB7_26014856_ChIP-Seq_BT474_Human1.12564885
118AHR_22903824_ChIP-Seq_MCF-7_Human1.12507184
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.11515883
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11308108
121RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11241186
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10871234
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10798154
124AR_20517297_ChIP-Seq_VCAP_Human1.09971135
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09223386
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07547703
127TCF4_22108803_ChIP-Seq_LS180_Human1.06945772
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06530675
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.06390477
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04960236
131SOX9_26525672_Chip-Seq_HEART_Mouse1.04656853
132ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04477933
133SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04069501
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.03988781
135GATA3_21867929_ChIP-Seq_TH1_Mouse1.03650537
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03354682
137ERG_20517297_ChIP-Seq_VCAP_Human1.03178128
138NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03073202
139BP1_19119308_ChIP-ChIP_Hs578T_Human1.01632392
140SPI1_26923725_Chip-Seq_HPCs_Mouse1.01559423
141PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01547292
142CDX2_22108803_ChIP-Seq_LS180_Human0.98992691
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98941562
144FOXH1_21741376_ChIP-Seq_EPCs_Human0.98884021
145RNF2_27304074_Chip-Seq_NSC_Mouse0.96718500
146ZFX_18555785_Chip-Seq_ESCs_Mouse0.96368676
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96123614
148REST_21632747_ChIP-Seq_MESCs_Mouse0.95473529
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95326068
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.94124735
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94124735
152SCL_19346495_ChIP-Seq_HPC-7_Human0.93958237
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.93759416
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93740751
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93696424
156JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93666916
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93655824
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93409091
159ETV1_20927104_ChIP-Seq_GIST48_Human0.92567365
160NANOG_20526341_ChIP-Seq_ESCs_Human0.92433971
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92259883
162ELK1_19687146_ChIP-ChIP_HELA_Human0.91828282
163FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91264733
164TAF15_26573619_Chip-Seq_HEK293_Human0.89894137
165GF1_26923725_Chip-Seq_HPCs_Mouse0.89132394
166UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87953105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.47992642
2MP0001929_abnormal_gametogenesis4.69997862
3MP0000569_abnormal_digit_pigmentation4.14466369
4MP0006292_abnormal_olfactory_placode3.78104110
5MP0002138_abnormal_hepatobiliary_system3.56175574
6MP0005647_abnormal_sex_gland3.55687519
7MP0005310_abnormal_salivary_gland3.19285055
8MP0005645_abnormal_hypothalamus_physiol2.97779385
9MP0002161_abnormal_fertility/fecundity2.80201530
10MP0002210_abnormal_sex_determination2.79844588
11MP0001145_abnormal_male_reproductive2.72062994
12MP0001765_abnormal_ion_homeostasis2.65498346
13MP0002102_abnormal_ear_morphology2.64072721
14MP0003300_gastrointestinal_ulcer2.62682129
15MP0008877_abnormal_DNA_methylation2.61618082
16MP0001968_abnormal_touch/_nociception2.55928541
17MP0002166_altered_tumor_susceptibility2.46915237
18MP0000653_abnormal_sex_gland2.41295707
19MP0008995_early_reproductive_senescence2.36995934
20MP0002638_abnormal_pupillary_reflex2.33265913
21MP0002132_abnormal_respiratory_system2.17923745
22MP0002139_abnormal_hepatobiliary_system2.13491311
23MP0006276_abnormal_autonomic_nervous2.09541131
24MP0010386_abnormal_urinary_bladder2.05874273
25MP0005410_abnormal_fertilization13.7424966
26MP0004147_increased_porphyrin_level1.95059031
27MP0001986_abnormal_taste_sensitivity1.88658340
28MP0008789_abnormal_olfactory_epithelium1.86808348
29MP0002822_catalepsy1.82774890
30MP0002006_tumorigenesis1.80776947
31MP0000613_abnormal_salivary_gland1.79420849
32MP0003880_abnormal_central_pattern1.74512808
33MP0005394_taste/olfaction_phenotype1.73834801
34MP0005499_abnormal_olfactory_system1.73834801
35MP0001873_stomach_inflammation1.71549585
36MP0010234_abnormal_vibrissa_follicle1.68908086
37MP0005084_abnormal_gallbladder_morpholo1.61325969
38MP0005085_abnormal_gallbladder_physiolo1.60200927
39MP0005636_abnormal_mineral_homeostasis1.59866190
40MP0004043_abnormal_pH_regulation1.55077306
41MP0003011_delayed_dark_adaptation1.54172380
42MP0001486_abnormal_startle_reflex1.50370964
43MP0002653_abnormal_ependyma_morphology1.47285390
44MP0000013_abnormal_adipose_tissue1.36890001
45MP0002282_abnormal_trachea_morphology1.35038437
46MP0003646_muscle_fatigue1.30767540
47MP0001970_abnormal_pain_threshold1.29262737
48MP0005670_abnormal_white_adipose1.28400340
49MP0003122_maternal_imprinting1.26800129
50MP0009745_abnormal_behavioral_response1.25526375
51MP0002733_abnormal_thermal_nociception1.24156559
52MP0001501_abnormal_sleep_pattern1.24031220
53MP0003718_maternal_effect1.23602772
54MP0002234_abnormal_pharynx_morphology1.22908484
55MP0002163_abnormal_gland_morphology1.22482862
56MP0009780_abnormal_chondrocyte_physiolo1.22404287
57MP0002272_abnormal_nervous_system1.22156378
58MP0002909_abnormal_adrenal_gland1.21129075
59MP0004233_abnormal_muscle_weight1.20971387
60MP0003195_calcinosis1.20067358
61MP0000631_abnormal_neuroendocrine_gland1.18743083
62MP0002160_abnormal_reproductive_system1.17208096
63MP0005174_abnormal_tail_pigmentation1.14303065
64MP0009764_decreased_sensitivity_to1.12443776
65MP0002734_abnormal_mechanical_nocicepti1.11357154
66MP0004142_abnormal_muscle_tone1.10918977
67MP0002009_preneoplasia1.09309619
68MP0004134_abnormal_chest_morphology1.09012871
69MP0005167_abnormal_blood-brain_barrier1.08824190
70MP0003183_abnormal_peptide_metabolism1.08187956
71MP0000427_abnormal_hair_cycle1.05274595
72MP0002928_abnormal_bile_duct1.01591905
73MP0005379_endocrine/exocrine_gland_phen1.00622932
74MP0004264_abnormal_extraembryonic_tissu1.00598396
75MP0002557_abnormal_social/conspecific_i0.97445554
76MP0002837_dystrophic_cardiac_calcinosis0.96532965
77MP0002735_abnormal_chemical_nociception0.96243166
78MP0003724_increased_susceptibility_to0.95607965
79MP0005195_abnormal_posterior_eye0.93830503
80MP0001293_anophthalmia0.93820334
81MP0000230_abnormal_systemic_arterial0.91800310
82MP0003121_genomic_imprinting0.90970920
83MP0003635_abnormal_synaptic_transmissio0.89550105
84MP0000537_abnormal_urethra_morphology0.88889736
85MP0000383_abnormal_hair_follicle0.88552198
86MP0005319_abnormal_enzyme/_coenzyme0.87646156
87MP0004133_heterotaxia0.86366834
88MP0001905_abnormal_dopamine_level0.85538516
89MP0004145_abnormal_muscle_electrophysio0.85354393
90MP0002572_abnormal_emotion/affect_behav0.83838235
91MP0003567_abnormal_fetal_cardiomyocyte0.83386234
92MP0001177_atelectasis0.81847419
93MP0002229_neurodegeneration0.81754621
94MP0005391_vision/eye_phenotype0.81649566
95MP0010368_abnormal_lymphatic_system0.81363878
96MP0005389_reproductive_system_phenotype0.81228844
97MP0009250_abnormal_appendicular_skeleto0.80338349
98MP0002938_white_spotting0.79632901
99MP0003786_premature_aging0.79558319
100MP0002127_abnormal_cardiovascular_syste0.79344037
101MP0001963_abnormal_hearing_physiology0.79307275
102MP0005187_abnormal_penis_morphology0.78976109
103MP0005623_abnormal_meninges_morphology0.78604826
104MP0005360_urolithiasis0.78290922
105MP0002752_abnormal_somatic_nervous0.78150367
106MP0005166_decreased_susceptibility_to0.77719433
107MP0003656_abnormal_erythrocyte_physiolo0.77429235
108MP0004484_altered_response_of0.76411961
109MP0001756_abnormal_urination0.76235382
110MP0002063_abnormal_learning/memory/cond0.76155599
111MP0005075_abnormal_melanosome_morpholog0.75965079
112MP0001299_abnormal_eye_distance/0.75646220
113MP0002067_abnormal_sensory_capabilities0.74053680
114MP0009765_abnormal_xenobiotic_induced0.71245346
115MP0002277_abnormal_respiratory_mucosa0.71126697
116MP0001764_abnormal_homeostasis0.70984505
117MP0008875_abnormal_xenobiotic_pharmacok0.70536723
118MP0002693_abnormal_pancreas_physiology0.68559405
119MP0006072_abnormal_retinal_apoptosis0.63188311
120MP0005220_abnormal_exocrine_pancreas0.62540667
121MP0000534_abnormal_ureter_morphology0.61780808
122MP0004019_abnormal_vitamin_homeostasis0.61648395
123MP0002295_abnormal_pulmonary_circulatio0.61369842
124MP0002136_abnormal_kidney_physiology0.56850492
125MP0001324_abnormal_eye_pigmentation0.56547665
126MP0001944_abnormal_pancreas_morphology0.56530828
127MP0003315_abnormal_perineum_morphology0.55631788
128MP0009643_abnormal_urine_homeostasis0.54383576
129MP0005365_abnormal_bile_salt0.53792111
130MP0008058_abnormal_DNA_repair0.53361266
131MP0002736_abnormal_nociception_after0.53325698
132MP0001919_abnormal_reproductive_system0.53065443
133MP0001663_abnormal_digestive_system0.49886239
134MP0005332_abnormal_amino_acid0.49747987
135MP0000343_altered_response_to0.48179478
136MP0000604_amyloidosis0.47030313
137MP0005646_abnormal_pituitary_gland0.46715738
138MP0009046_muscle_twitch0.45024238
139MP0002115_abnormal_skeleton_extremities0.44206906
140MP0005381_digestive/alimentary_phenotyp0.43156090
141MP0004036_abnormal_muscle_relaxation0.41670108
142MP0009384_cardiac_valve_regurgitation0.40595267
143MP0003186_abnormal_redox_activity0.40531718
144MP0001119_abnormal_female_reproductive0.39879589
145MP0001664_abnormal_digestion0.39873880
146MP0002796_impaired_skin_barrier0.38853089
147MP0000538_abnormal_urinary_bladder0.38684415
148MP0001348_abnormal_lacrimal_gland0.38524734
149MP0003699_abnormal_female_reproductive0.35089519
150MP0003959_abnormal_lean_body0.34910028
151MP0001984_abnormal_olfaction0.34222209
152MP0004885_abnormal_endolymph0.33506429
153MP0008469_abnormal_protein_level0.33344404
154MP0010155_abnormal_intestine_physiology0.33179823
155MP0005551_abnormal_eye_electrophysiolog0.32438908
156MP0002135_abnormal_kidney_morphology0.31740459
157MP0003866_abnormal_defecation0.31208060
158MP0010329_abnormal_lipoprotein_level0.30889156
159MP0002876_abnormal_thyroid_physiology0.28538985
160MP0008872_abnormal_physiological_respon0.28202711
161MP0002109_abnormal_limb_morphology0.27774266
162MP0003936_abnormal_reproductive_system0.27295898
163MP0009697_abnormal_copulation0.26133544
164MP0005253_abnormal_eye_physiology0.25326741
165MP0006082_CNS_inflammation0.24763867
166MP0001845_abnormal_inflammatory_respons0.24758173

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.81408310
2Abnormal respiratory epithelium morphology (HP:0012253)8.81408310
3Abnormal respiratory motile cilium physiology (HP:0012261)8.57528224
4Abnormal ciliary motility (HP:0012262)7.42940627
5Chronic bronchitis (HP:0004469)6.84551709
6Rhinitis (HP:0012384)6.58194723
7Nasal polyposis (HP:0100582)5.62136083
8Infertility (HP:0000789)5.48425557
9Abnormality of the nasal mucosa (HP:0000433)4.52995923
10Male infertility (HP:0003251)4.51644893
11Bronchiectasis (HP:0002110)3.82921120
12Congenital stationary night blindness (HP:0007642)3.78048736
13Bronchitis (HP:0012387)3.69710065
14Pancreatic cysts (HP:0001737)3.64485478
15Abnormal rod and cone electroretinograms (HP:0008323)3.51419337
16Pancreatic fibrosis (HP:0100732)3.49321230
17Pigmentary retinal degeneration (HP:0001146)3.41869401
18True hermaphroditism (HP:0010459)3.34442642
19Recurrent sinusitis (HP:0011108)3.29016070
20Abnormality of cochlea (HP:0000375)3.28525314
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19347640
22Nephronophthisis (HP:0000090)3.07065599
23Abnormal biliary tract physiology (HP:0012439)2.92357488
24Bile duct proliferation (HP:0001408)2.92357488
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.85465047
26Asymmetric septal hypertrophy (HP:0001670)2.85319856
27Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.85194252
28Abnormal protein N-linked glycosylation (HP:0012347)2.85194252
29Abnormal protein glycosylation (HP:0012346)2.85194252
30Abnormal glycosylation (HP:0012345)2.85194252
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81716452
32Abnormality of alanine metabolism (HP:0010916)2.81716452
33Hyperalaninemia (HP:0003348)2.81716452
34Tubulointerstitial nephritis (HP:0001970)2.75119386
35Hemiparesis (HP:0001269)2.74099895
36Hyperventilation (HP:0002883)2.72007132
37Congenital hepatic fibrosis (HP:0002612)2.71222282
38Progressive microcephaly (HP:0000253)2.71041326
39Attenuation of retinal blood vessels (HP:0007843)2.70792120
40Medial flaring of the eyebrow (HP:0010747)2.69779337
41Recurrent otitis media (HP:0000403)2.69685372
42Type II lissencephaly (HP:0007260)2.68215497
43Short tibia (HP:0005736)2.66776889
44Ketosis (HP:0001946)2.60635648
45Type I transferrin isoform profile (HP:0003642)2.58475663
46Hyperinsulinemic hypoglycemia (HP:0000825)2.57466476
47Abnormality of the metopic suture (HP:0005556)2.56499394
48Neonatal respiratory distress (HP:0002643)2.51836811
49Fair hair (HP:0002286)2.46589677
50Ketoacidosis (HP:0001993)2.42854728
51Abnormal spermatogenesis (HP:0008669)2.42711931
52Methylmalonic acidemia (HP:0002912)2.35967563
53Pendular nystagmus (HP:0012043)2.30765070
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.29068686
55Abnormality of the renal medulla (HP:0100957)2.28068220
56Increased hepatocellular lipid droplets (HP:0006565)2.27427143
57Hyperphosphatemia (HP:0002905)2.27320590
58Congenital, generalized hypertrichosis (HP:0004540)2.26942838
59Tongue fasciculations (HP:0001308)2.24798718
60Lipid accumulation in hepatocytes (HP:0006561)2.21812218
61Lissencephaly (HP:0001339)2.20953467
62Morphological abnormality of the inner ear (HP:0011390)2.20243229
63Cerebellar dysplasia (HP:0007033)2.19309684
64Inability to walk (HP:0002540)2.19008070
65Abolished electroretinogram (ERG) (HP:0000550)2.16212141
66Aplasia of the phalanges of the hand (HP:0009802)2.15815409
67Aplasia involving bones of the extremities (HP:0009825)2.15815409
68Aplasia involving bones of the upper limbs (HP:0009823)2.15815409
69Vascular calcification (HP:0004934)2.15564310
70Subcapsular cataract (HP:0000523)2.13176553
71Hyperglycinuria (HP:0003108)2.11599902
72Hypoplasia of the pons (HP:0012110)2.10564659
73Amyotrophic lateral sclerosis (HP:0007354)2.09072433
74Progressive inability to walk (HP:0002505)2.07034421
75Abnormality of midbrain morphology (HP:0002418)2.02472782
76Molar tooth sign on MRI (HP:0002419)2.02472782
77Postaxial foot polydactyly (HP:0001830)2.01428703
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.1391031
79Absent/shortened dynein arms (HP:0200106)13.1391031
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7229066
81Prominent metopic ridge (HP:0005487)1.99741055
82Methylmalonic aciduria (HP:0012120)1.99739745
83Drooling (HP:0002307)1.99664967
84Abnormality of glycine metabolism (HP:0010895)1.99107362
85Abnormality of serine family amino acid metabolism (HP:0010894)1.99107362
86Optic nerve hypoplasia (HP:0000609)1.98549883
87Abnormality of renal excretion (HP:0011036)1.98127686
88Genital tract atresia (HP:0001827)1.95195340
89Colon cancer (HP:0003003)1.95042564
90Muscle fibrillation (HP:0010546)1.94516235
91Polyphagia (HP:0002591)1.93524703
92Retinal dysplasia (HP:0007973)1.92559370
93Choroideremia (HP:0001139)1.92553688
94Hypomagnesemia (HP:0002917)1.92161920
95Cardiovascular calcification (HP:0011915)1.91933867
96Renal Fanconi syndrome (HP:0001994)1.91275022
97Retinitis pigmentosa (HP:0000510)1.90909416
98Bony spicule pigmentary retinopathy (HP:0007737)1.89948858
99Mitochondrial inheritance (HP:0001427)1.87322547
100Abnormality of the pons (HP:0007361)1.86690108
101Vaginal atresia (HP:0000148)1.86070081
102Cone-rod dystrophy (HP:0000548)1.85555970
103Chronic sinusitis (HP:0011109)1.85242668
104Abnormality of secondary sexual hair (HP:0009888)1.84219801
105Abnormality of the axillary hair (HP:0100134)1.84219801
106Bundle branch block (HP:0011710)1.83665697
107Hyperglycinemia (HP:0002154)1.82562799
108Specific learning disability (HP:0001328)1.81963926
109Increased CSF lactate (HP:0002490)1.80331982
110Abnormality of the vitamin B12 metabolism (HP:0004341)1.80116533
111Abnormality of vitamin B metabolism (HP:0004340)1.79131584
112Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78851689
113Dyskinesia (HP:0100660)1.77554376
114Pachygyria (HP:0001302)1.77074700
115Tubular atrophy (HP:0000092)1.76862177
116Sclerocornea (HP:0000647)1.76627668
117Gait imbalance (HP:0002141)1.76104148
118Excessive salivation (HP:0003781)1.76086119
119Poor coordination (HP:0002370)1.75557599
120Renal cortical cysts (HP:0000803)1.74866133
121Congenital primary aphakia (HP:0007707)1.74763187
122Keratoconus (HP:0000563)1.74480249
123Increased corneal curvature (HP:0100692)1.74480249
124Hepatocellular necrosis (HP:0001404)1.73776322
125Abnormality of renal resorption (HP:0011038)1.73390224
126Supernumerary spleens (HP:0009799)1.73222610
127Facial shape deformation (HP:0011334)1.70112157
128Potter facies (HP:0002009)1.70112157
129Short femoral neck (HP:0100864)1.69359452
130Abnormality of the dental root (HP:0006486)1.68964072
131Taurodontia (HP:0000679)1.68964072
132Abnormality of permanent molar morphology (HP:0011071)1.68964072
133Vacuolated lymphocytes (HP:0001922)1.68855606
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67431359
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.64813994
136Aplasia/Hypoplasia of the fibula (HP:0006492)1.64754784
137Tubulointerstitial abnormality (HP:0001969)1.62574924
138Stage 5 chronic kidney disease (HP:0003774)1.62457201
139Azoospermia (HP:0000027)1.60509564
140Recurrent bronchitis (HP:0002837)1.59815635
141Exocrine pancreatic insufficiency (HP:0001738)1.59780684
142Hypoplasia of the uterus (HP:0000013)1.59050641
143Abnormality of the 2nd finger (HP:0004100)1.58559509
144Abnormality of molar morphology (HP:0011070)1.56195045
145Abnormality of molar (HP:0011077)1.56195045
146Epiphyseal dysplasia (HP:0002656)1.56085936
147Papillary thyroid carcinoma (HP:0002895)1.53339752
148Nephrogenic diabetes insipidus (HP:0009806)1.48791972
149Abnormality of the dental pulp (HP:0006479)1.48147456
150Chronic hepatic failure (HP:0100626)1.47578348
151Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.46622971
152Abnormal tarsal ossification (HP:0008369)1.46279779
153Abnormality of the proximal phalanges of the hand (HP:0009834)1.44449051
154Fibular aplasia (HP:0002990)1.43522828
155Rectal prolapse (HP:0002035)1.43166842
156Abnormality of saccadic eye movements (HP:0000570)1.41840035
157Fibular hypoplasia (HP:0003038)1.39908181
158Postaxial hand polydactyly (HP:0001162)1.39551112
159Abnormal urine output (HP:0012590)1.39469721
160Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.39195931
161Polydipsia (HP:0001959)1.39080824
162Abnormal drinking behavior (HP:0030082)1.39080824
163Barrel-shaped chest (HP:0001552)1.38861639
164Constricted visual fields (HP:0001133)1.37528628
165Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.35893584
166Cystic liver disease (HP:0006706)1.35846341
167Dyschromatopsia (HP:0007641)1.35756298
168Impaired smooth pursuit (HP:0007772)1.35608969
169Abnormality of the neuromuscular junction (HP:0003398)1.34529136
170Fatigable weakness (HP:0003473)1.34529136
171Hypergonadotropic hypogonadism (HP:0000815)1.31600699
172Degeneration of the lateral corticospinal tracts (HP:0002314)1.29292369
173Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.29292369
174Thoracolumbar scoliosis (HP:0002944)1.29291329
175Decreased central vision (HP:0007663)1.28522142
176Beaking of vertebral bodies (HP:0004568)1.27004454
177Bell-shaped thorax (HP:0001591)1.25581241
178Abnormal foot bone ossification (HP:0010675)1.25226328
179Abnormality of the renal cortex (HP:0011035)1.25060570
180Hypoplastic ischia (HP:0003175)1.23830295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.79785409
2PDK39.79785409
3PDK27.23296440
4MAP4K25.85459952
5AKT32.88590359
6BLK2.13212168
7TESK12.00582078
8ZAK1.93273432
9CASK1.89649219
10ADRBK21.85400710
11LMTK21.84576897
12STK391.81839007
13TRIM281.76537822
14GRK51.73554343
15MST41.71638671
16BRD41.71047687
17IRAK41.65405113
18ICK1.56282165
19FRK1.46859741
20ERN11.43029035
21TAOK31.34947446
22MAP3K41.33506433
23PRKD31.28894173
24DAPK21.27856726
25WNK31.26864686
26LATS11.26689779
27BMPR1B1.18243796
28BCR1.15037983
29RPS6KA41.12716971
30TXK1.12328473
31MAPK131.10130879
32PDK11.05455110
33BCKDK1.00933019
34PRKCE0.99263868
35EEF2K0.97874564
36WNK40.97287480
37TIE10.96424990
38RPS6KA50.96390322
39CAMKK20.96239462
40MARK10.94280573
41PTK2B0.91739877
42TLK10.88837788
43INSRR0.88623940
44DYRK20.87247550
45TEC0.84911869
46PLK20.84560935
47EPHA30.81418528
48IRAK10.80771029
49MAP2K70.80745753
50NTRK30.80185968
51ADRBK10.78195874
52FLT30.77419284
53SGK2230.70112136
54SGK4940.70112136
55STK38L0.69337720
56NEK60.69112508
57PBK0.67476472
58EPHA40.67421271
59CAMK2D0.66910007
60SGK20.66693430
61GRK60.65185311
62DAPK10.65050755
63VRK10.63223943
64PIK3CG0.56800453
65STK30.56214715
66MKNK10.55269650
67NUAK10.54354728
68SYK0.53876793
69STK380.51726732
70ATR0.50554185
71IRAK20.50473708
72MAP2K60.47278654
73SIK10.44325228
74TNIK0.43936614
75RIPK40.42724281
76CAMK40.42225832
77MYLK0.41420521
78CSNK1A10.41415710
79CAMK2A0.40418363
80OXSR10.39894126
81PDPK10.38811306
82EPHA20.38245201
83WEE10.38139643
84PIM10.38092154
85MAP3K90.37387909
86ITK0.35932503
87LYN0.35864750
88ERBB40.35304855
89DYRK1B0.32830190
90SGK10.32752071
91ERBB30.32443293
92HIPK20.31874586
93PKN10.30884735
94PRKACA0.30874370
95CLK10.30037952
96IKBKB0.28817903
97MAP3K20.28466607
98STK100.28147839
99PIK3CA0.27729748
100ERBB20.27289243
101ABL10.26803161
102NTRK20.26586086
103MKNK20.25935516
104TSSK60.25442642
105CSNK1G10.24725682
106CSNK1G30.24390782
107RPS6KA60.23506253
108DYRK1A0.23401377
109CSNK1A1L0.23359100
110PRKG20.22935288
111DDR20.22688125
112WNK10.22149633
113CSNK1G20.21797324
114RPS6KB10.21600451
115YES10.20072223
116RPS6KB20.19558049
117PTK60.18227173
118PRKCQ0.16975969
119TESK20.16319240
120PINK10.16039132
121NEK20.16029679
122PASK0.15780301
123CAMKK10.15383297
124FER0.15082095
125CSF1R0.14862810
126MAPKAPK30.14326901
127JAK30.14324020
128PLK40.13638578
129PNCK0.12643249
130TNK20.11708624
131PRKAA10.11417487
132RPS6KA20.10827537
133PRKCZ0.10498239
134LRRK20.09833417
135BRSK20.09683246
136PAK20.09503625
137MET0.09464605
138MELK0.08660135
139ROCK10.08186596
140MTOR0.07937779
141MAP3K30.07912691
142EIF2AK30.07224575
143MAP2K20.06563735
144MST1R0.06140471
145PAK10.05879587
146PRKCI0.05157422
147CSNK2A20.05056732
148CHEK10.04792678
149MAPKAPK50.04241984
150TTN0.03931581
151CCNB10.03710541
152GRK10.03529391
153PRKCA0.03464820
154PRKACB0.03452256
155GSK3A0.02932051
156BTK0.02896583
157ROCK20.02860706
158CHEK20.02846838
159TRIB30.02735417
160PRKG10.02412526
161DYRK30.02143856
162PRKCG0.01104060
163PHKG10.00587945
164PHKG20.00587945
165EGFR0.00400259
166RPS6KA10.00228137
167IGF1R-0.0107885
168RPS6KA3-0.0084796
169PRKACG-0.0080455
170JAK2-0.0062941

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.10041696
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.06260260
3Sulfur metabolism_Homo sapiens_hsa009203.93658119
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.38011541
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.33524588
6Pyruvate metabolism_Homo sapiens_hsa006203.23359414
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.17961273
8Propanoate metabolism_Homo sapiens_hsa006402.85775068
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60770033
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55404429
11Vitamin B6 metabolism_Homo sapiens_hsa007502.36827046
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.34389583
13Regulation of autophagy_Homo sapiens_hsa041402.32393341
14Protein export_Homo sapiens_hsa030602.31929770
15Butanoate metabolism_Homo sapiens_hsa006502.30831002
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23545473
17Renin-angiotensin system_Homo sapiens_hsa046142.19786656
18Collecting duct acid secretion_Homo sapiens_hsa049662.10105945
19Caffeine metabolism_Homo sapiens_hsa002322.09448916
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07878301
21RNA polymerase_Homo sapiens_hsa030202.04357166
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.95848558
23Fatty acid biosynthesis_Homo sapiens_hsa000611.86594772
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77915342
25Glucagon signaling pathway_Homo sapiens_hsa049221.76620216
26Asthma_Homo sapiens_hsa053101.73118518
27Vibrio cholerae infection_Homo sapiens_hsa051101.71563468
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65343736
29Other glycan degradation_Homo sapiens_hsa005111.58925243
30Phototransduction_Homo sapiens_hsa047441.57312946
31Nicotine addiction_Homo sapiens_hsa050331.54490162
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.53755296
33Inositol phosphate metabolism_Homo sapiens_hsa005621.52885981
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50661170
35N-Glycan biosynthesis_Homo sapiens_hsa005101.49321176
36Mineral absorption_Homo sapiens_hsa049781.48957788
37Type I diabetes mellitus_Homo sapiens_hsa049401.48876493
38Protein digestion and absorption_Homo sapiens_hsa049741.45780502
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45498092
40Fanconi anemia pathway_Homo sapiens_hsa034601.44361009
41Peroxisome_Homo sapiens_hsa041461.43570254
42Linoleic acid metabolism_Homo sapiens_hsa005911.41245680
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38252365
44RNA degradation_Homo sapiens_hsa030181.37959276
45Thyroid hormone synthesis_Homo sapiens_hsa049181.37747194
46Nitrogen metabolism_Homo sapiens_hsa009101.37629893
47Tryptophan metabolism_Homo sapiens_hsa003801.37062625
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.36902128
49Selenocompound metabolism_Homo sapiens_hsa004501.36590369
50Glycerolipid metabolism_Homo sapiens_hsa005611.35438880
51Fructose and mannose metabolism_Homo sapiens_hsa000511.31811334
52Oxidative phosphorylation_Homo sapiens_hsa001901.29867231
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28865126
54Base excision repair_Homo sapiens_hsa034101.25300857
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24407045
56Homologous recombination_Homo sapiens_hsa034401.23906426
57Morphine addiction_Homo sapiens_hsa050321.23474684
58Steroid biosynthesis_Homo sapiens_hsa001001.19992746
59Allograft rejection_Homo sapiens_hsa053301.19827079
60Olfactory transduction_Homo sapiens_hsa047401.19681157
61Autoimmune thyroid disease_Homo sapiens_hsa053201.15551673
62Parkinsons disease_Homo sapiens_hsa050121.14931105
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13818682
64Synaptic vesicle cycle_Homo sapiens_hsa047211.13052960
65Oocyte meiosis_Homo sapiens_hsa041141.12363576
66Carbon metabolism_Homo sapiens_hsa012001.12247093
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10632329
68Antigen processing and presentation_Homo sapiens_hsa046121.08975857
69Graft-versus-host disease_Homo sapiens_hsa053321.06162506
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01305526
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95993767
72Proteasome_Homo sapiens_hsa030500.93874645
73Retinol metabolism_Homo sapiens_hsa008300.92490545
74PPAR signaling pathway_Homo sapiens_hsa033200.92152542
75Fatty acid degradation_Homo sapiens_hsa000710.91355947
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91114725
77Renin secretion_Homo sapiens_hsa049240.87766462
78One carbon pool by folate_Homo sapiens_hsa006700.87496998
79Amphetamine addiction_Homo sapiens_hsa050310.87378075
80Huntingtons disease_Homo sapiens_hsa050160.85763863
81Bile secretion_Homo sapiens_hsa049760.85443655
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82887547
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82854316
84Arginine and proline metabolism_Homo sapiens_hsa003300.81064057
85Pentose phosphate pathway_Homo sapiens_hsa000300.79893285
86beta-Alanine metabolism_Homo sapiens_hsa004100.79340328
87Biosynthesis of amino acids_Homo sapiens_hsa012300.76508401
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75715022
89Salivary secretion_Homo sapiens_hsa049700.72810426
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.72249539
91GABAergic synapse_Homo sapiens_hsa047270.71819090
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70665781
93Pyrimidine metabolism_Homo sapiens_hsa002400.69986039
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.68941210
95Ether lipid metabolism_Homo sapiens_hsa005650.68552367
96Pancreatic secretion_Homo sapiens_hsa049720.66484556
97Cocaine addiction_Homo sapiens_hsa050300.66139242
98Basal transcription factors_Homo sapiens_hsa030220.65381152
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64998196
100Estrogen signaling pathway_Homo sapiens_hsa049150.64657751
101Legionellosis_Homo sapiens_hsa051340.64349588
102Insulin secretion_Homo sapiens_hsa049110.62934515
103Fatty acid elongation_Homo sapiens_hsa000620.61563317
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.61136853
105Staphylococcus aureus infection_Homo sapiens_hsa051500.61084777
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61064279
107Gastric acid secretion_Homo sapiens_hsa049710.61036378
108Tight junction_Homo sapiens_hsa045300.59261092
109ABC transporters_Homo sapiens_hsa020100.58183296
110Glutathione metabolism_Homo sapiens_hsa004800.58125245
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56575381
112Dorso-ventral axis formation_Homo sapiens_hsa043200.55873857
113Serotonergic synapse_Homo sapiens_hsa047260.55805721
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54311586
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53559143
116Calcium signaling pathway_Homo sapiens_hsa040200.52492369
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52115214
118RNA transport_Homo sapiens_hsa030130.51755872
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50596028
120Arachidonic acid metabolism_Homo sapiens_hsa005900.50235587
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49637412
122Sphingolipid metabolism_Homo sapiens_hsa006000.49603871
123Fat digestion and absorption_Homo sapiens_hsa049750.48301738
124Metabolic pathways_Homo sapiens_hsa011000.47227660
125Non-homologous end-joining_Homo sapiens_hsa034500.46733952
126Cardiac muscle contraction_Homo sapiens_hsa042600.45697096
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45659290
128Prostate cancer_Homo sapiens_hsa052150.45393638
129Chemical carcinogenesis_Homo sapiens_hsa052040.44749068
130Alzheimers disease_Homo sapiens_hsa050100.43711763
131Mismatch repair_Homo sapiens_hsa034300.43376419
132Vitamin digestion and absorption_Homo sapiens_hsa049770.42847871
133Glutamatergic synapse_Homo sapiens_hsa047240.40864788
134Long-term depression_Homo sapiens_hsa047300.40504523
135Circadian entrainment_Homo sapiens_hsa047130.40425850
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40314782
137Fatty acid metabolism_Homo sapiens_hsa012120.39380987
138Tyrosine metabolism_Homo sapiens_hsa003500.39149130
139Circadian rhythm_Homo sapiens_hsa047100.38708475
140Rheumatoid arthritis_Homo sapiens_hsa053230.37030028
141Sulfur relay system_Homo sapiens_hsa041220.36754245
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36138422
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33017666
144Endocytosis_Homo sapiens_hsa041440.31847163
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31325654
146Long-term potentiation_Homo sapiens_hsa047200.30684483
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.29455586
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29200079
149cAMP signaling pathway_Homo sapiens_hsa040240.28838033
150Wnt signaling pathway_Homo sapiens_hsa043100.28770341
151Adherens junction_Homo sapiens_hsa045200.28511809
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28016596
153AMPK signaling pathway_Homo sapiens_hsa041520.27357947
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.27342121
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26111205
156Purine metabolism_Homo sapiens_hsa002300.22072514
157ECM-receptor interaction_Homo sapiens_hsa045120.21971743
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21836455
159Taste transduction_Homo sapiens_hsa047420.20398320
160Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19524092
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.19077418
162Influenza A_Homo sapiens_hsa051640.18920716
163Arginine biosynthesis_Homo sapiens_hsa002200.18240019

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »