MS4A6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.99323654
2positive regulation of gamma-delta T cell activation (GO:0046645)5.61242381
3immunoglobulin mediated immune response (GO:0016064)5.38791485
4detection of other organism (GO:0098543)5.09991942
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.06958825
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.06958825
7modulation by symbiont of host immune response (GO:0052553)5.06958825
8positive regulation by symbiont of host defense response (GO:0052509)5.06958825
9modulation by symbiont of host defense response (GO:0052031)5.06958825
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.06958825
11response to peptidoglycan (GO:0032494)5.01540959
12macrophage activation involved in immune response (GO:0002281)4.86338205
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80532019
14detection of bacterium (GO:0016045)4.76346409
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74522645
16negative regulation of cell killing (GO:0031342)4.74522645
17negative regulation of interleukin-12 production (GO:0032695)4.67573908
18detection of molecule of bacterial origin (GO:0032490)4.65793459
19detection of external biotic stimulus (GO:0098581)4.55169393
20microglial cell activation (GO:0001774)4.51557022
21positive regulation of mast cell activation (GO:0033005)4.41663878
22positive regulation of mast cell degranulation (GO:0043306)4.23878773
23positive regulation of mast cell activation involved in immune response (GO:0033008)4.23878773
24antigen processing and presentation of endogenous antigen (GO:0019883)4.14436401
25positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.12081740
26cellular extravasation (GO:0045123)4.11499472
27detection of biotic stimulus (GO:0009595)4.10608157
28B cell mediated immunity (GO:0019724)4.09960660
29regulation of mast cell degranulation (GO:0043304)4.07333802
30interferon-gamma-mediated signaling pathway (GO:0060333)4.00151559
31regulation of gamma-delta T cell activation (GO:0046643)3.99263677
32neutrophil activation (GO:0042119)3.98071071
33macrophage activation (GO:0042116)3.96880229
34regulation of myeloid leukocyte mediated immunity (GO:0002886)3.91272539
35myeloid cell activation involved in immune response (GO:0002275)3.87290284
36granulocyte activation (GO:0036230)3.83052764
37regulation of mast cell activation (GO:0033003)3.82081578
38regulation of mast cell activation involved in immune response (GO:0033006)3.81188488
39regulation of B cell receptor signaling pathway (GO:0050855)3.79755762
40regulation of interferon-beta biosynthetic process (GO:0045357)3.74767178
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.67560846
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53253067
43respiratory burst (GO:0045730)3.50649980
44regulation of leukocyte degranulation (GO:0043300)3.50557293
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44946110
46response to host immune response (GO:0052572)3.44946110
47regulation of hypersensitivity (GO:0002883)3.40252213
48regulation of antigen processing and presentation (GO:0002577)3.32299243
49regulation of gamma-delta T cell differentiation (GO:0045586)3.32098710
50regulation of tolerance induction (GO:0002643)3.31234244
51antigen processing and presentation via MHC class Ib (GO:0002475)3.28696988
52positive regulation of leukocyte degranulation (GO:0043302)3.27258310
53regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24957052
54positive regulation of antigen processing and presentation (GO:0002579)3.24840840
55regulation of T cell tolerance induction (GO:0002664)3.23330717
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22592560
57neutrophil mediated immunity (GO:0002446)3.22347442
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.20972902
59T-helper 1 type immune response (GO:0042088)3.20699835
60response to muramyl dipeptide (GO:0032495)3.20673243
61positive regulation of cellular amide metabolic process (GO:0034250)3.20126025
62production of molecular mediator involved in inflammatory response (GO:0002532)3.19995147
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.19893793
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18910831
65defense response to protozoan (GO:0042832)3.16970701
66positive regulation of type 2 immune response (GO:0002830)3.15522645
67leukocyte aggregation (GO:0070486)3.14094501
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14020755
69negative regulation of T cell mediated immunity (GO:0002710)3.12362382
70regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12237516
71positive thymic T cell selection (GO:0045059)3.11196338
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10323202
73positive regulation of B cell differentiation (GO:0045579)3.09348238
74myeloid leukocyte mediated immunity (GO:0002444)3.08820434
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08500874
76response to host (GO:0075136)3.08500874
77response to host defenses (GO:0052200)3.08500874
78cellular response to interferon-gamma (GO:0071346)3.08403414
79regulation of T-helper 2 cell differentiation (GO:0045628)3.05422597
80type I interferon signaling pathway (GO:0060337)3.00827851
81cellular response to type I interferon (GO:0071357)3.00827851
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99664365
83negative regulation of leukocyte mediated immunity (GO:0002704)2.98751683
84response to type I interferon (GO:0034340)2.97646689
85myeloid leukocyte activation (GO:0002274)2.94264085
86cell wall macromolecule catabolic process (GO:0016998)2.93661654
87leukocyte degranulation (GO:0043299)2.93486514
88regulation of regulated secretory pathway (GO:1903305)2.92773725
89positive regulation of interferon-alpha production (GO:0032727)2.91303583
90regulation of interferon-alpha production (GO:0032647)2.90218793
91response to protozoan (GO:0001562)2.88376132
92negative regulation of erythrocyte differentiation (GO:0045647)2.87969833
93B cell receptor signaling pathway (GO:0050853)2.84911047
94response to interferon-gamma (GO:0034341)2.84495957
95regulation of interleukin-8 biosynthetic process (GO:0045414)2.83335318
96positive regulation of monocyte chemotaxis (GO:0090026)2.82371366
97mast cell activation (GO:0045576)2.80605276
98negative regulation of cytokine production involved in immune response (GO:0002719)2.80246449
99positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79778896
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78400531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.51663074
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.16398213
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.74805330
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.95258497
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65906130
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50646606
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44402802
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22964485
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22807491
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10655239
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05828931
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96140628
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79908883
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.74654006
15* SPI1_23547873_ChIP-Seq_NB4_Human2.69107157
16VDR_24763502_ChIP-Seq_THP-1_Human2.65055785
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61254285
18SPI1_23127762_ChIP-Seq_K562_Human2.56459151
19SCL_19346495_ChIP-Seq_HPC-7_Human2.50737307
20VDR_24787735_ChIP-Seq_THP-1_Human2.44265937
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39111121
22RUNX_20019798_ChIP-Seq_JUKART_Human2.34193433
23VDR_21846776_ChIP-Seq_THP-1_Human2.31482399
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28460745
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23633066
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10127756
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09485926
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08571506
29MYB_26560356_Chip-Seq_TH2_Human2.05281263
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03265817
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.92259090
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91708315
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74594908
34MAF_26560356_Chip-Seq_TH1_Human1.73281627
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71708682
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68931052
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64677063
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.64428412
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61809397
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.61282589
41MYB_26560356_Chip-Seq_TH1_Human1.60428766
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58872320
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57276038
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52078795
45GATA3_27048872_Chip-Seq_THYMUS_Human1.49391363
46UTX_26944678_Chip-Seq_JUKART_Human1.48646960
47GATA1_22025678_ChIP-Seq_K562_Human1.47303786
48PU_27001747_Chip-Seq_BMDM_Mouse1.46690670
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.40276309
50GATA3_26560356_Chip-Seq_TH2_Human1.37253581
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34152026
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30547051
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29216488
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28803678
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28121201
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25675563
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25179138
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21060747
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20614199
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20383096
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20006109
62TCF7_22412390_ChIP-Seq_EML_Mouse1.19781180
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19084289
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18958766
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17207419
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15030214
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14854652
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11933764
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11799100
70MAF_26560356_Chip-Seq_TH2_Human1.10012828
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08551952
72GATA1_19941826_ChIP-Seq_K562_Human1.06359130
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.04759179
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03836186
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02173206
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99177871
77MYC_22102868_ChIP-Seq_BL_Human0.98892375
78KDM2B_26808549_Chip-Seq_DND41_Human0.97536992
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95282918
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90911476
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90817416
82STAT1_20625510_ChIP-Seq_HELA_Human0.90454125
83GATA2_19941826_ChIP-Seq_K562_Human0.90096701
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85328874
85* SMRT_27268052_Chip-Seq_Bcells_Human0.84204117
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82676806
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80091149
88LXR_22292898_ChIP-Seq_THP-1_Human0.79910332
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79792969
90GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78035572
91LXR_22158963_ChIP-Seq_LIVER_Mouse0.77844624
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76763893
93SPI1_20517297_ChIP-Seq_HL60_Human0.76702380
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76497066
95BCL6_27268052_Chip-Seq_Bcells_Human0.76432006
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76058298
97TFEB_21752829_ChIP-Seq_HELA_Human0.71288119
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.71132462
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69391700
100RXR_22158963_ChIP-Seq_LIVER_Mouse0.68422149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.40372704
2MP0001835_abnormal_antigen_presentation4.29768772
3MP0003303_peritoneal_inflammation3.59767841
4MP0003436_decreased_susceptibility_to3.55702803
5MP0006082_CNS_inflammation3.32686489
6MP0002419_abnormal_innate_immunity3.18008809
7MP0005671_abnormal_response_to3.15890823
8MP0009785_altered_susceptibility_to3.01458760
9MP0005025_abnormal_response_to2.87847826
10MP0005000_abnormal_immune_tolerance2.79570695
11MP0001800_abnormal_humoral_immune2.78450221
12MP0002148_abnormal_hypersensitivity_rea2.76598027
13MP0005058_abnormal_lysosome_morphology2.73744823
14MP0001790_abnormal_immune_system2.66161611
15MP0005387_immune_system_phenotype2.66161611
16MP0000685_abnormal_immune_system2.59019534
17MP0002452_abnormal_antigen_presenting2.56343171
18MP0002723_abnormal_immune_serum2.51569806
19MP0003172_abnormal_lysosome_physiology2.37698136
20MP0003300_gastrointestinal_ulcer2.33150157
21MP0002420_abnormal_adaptive_immunity2.31324916
22MP0001819_abnormal_immune_cell2.30529435
23MP0003191_abnormal_cellular_cholesterol2.16312730
24MP0005464_abnormal_platelet_physiology2.12742297
25MP0001533_abnormal_skeleton_physiology2.05320556
26MP0009764_decreased_sensitivity_to1.90064683
27MP0001845_abnormal_inflammatory_respons1.86310076
28MP0003828_pulmonary_edema1.85623659
29MP0002405_respiratory_system_inflammati1.72305450
30MP0010155_abnormal_intestine_physiology1.71403731
31MP0003075_altered_response_to1.69615081
32MP0000716_abnormal_immune_system1.66297819
33MP0008469_abnormal_protein_level1.62707308
34MP0003690_abnormal_glial_cell1.62685366
35MP0000343_altered_response_to1.58342119
36MP0000569_abnormal_digit_pigmentation1.53841319
37MP0002398_abnormal_bone_marrow1.53440221
38MP0009840_abnormal_foam_cell1.53372158
39MP0002998_abnormal_bone_remodeling1.50267960
40MP0000604_amyloidosis1.48092149
41MP0004947_skin_inflammation1.43093592
42MP0001853_heart_inflammation1.40732501
43MP0003763_abnormal_thymus_physiology1.39798021
44MP0009278_abnormal_bone_marrow1.39773460
45MP0000689_abnormal_spleen_morphology1.38949445
46MP0000465_gastrointestinal_hemorrhage1.38735377
47MP0000858_altered_metastatic_potential1.37074519
48MP0004883_abnormal_blood_vessel1.35591133
49MP0009333_abnormal_splenocyte_physiolog1.35325131
50MP0005397_hematopoietic_system_phenotyp1.35277898
51MP0001545_abnormal_hematopoietic_system1.35277898
52MP0003183_abnormal_peptide_metabolism1.34333382
53MP0002166_altered_tumor_susceptibility1.33857458
54MP0005310_abnormal_salivary_gland1.31883120
55MP0008260_abnormal_autophagy1.31365972
56MP0002429_abnormal_blood_cell1.27835069
57MP0003866_abnormal_defecation1.25232177
58MP0002722_abnormal_immune_system1.24814405
59MP0005166_decreased_susceptibility_to1.23790278
60MP0003806_abnormal_nucleotide_metabolis1.19244610
61MP0005164_abnormal_response_to1.15648122
62MP0005451_abnormal_body_composition1.12214432
63MP0008004_abnormal_stomach_pH1.11709681
64MP0003448_altered_tumor_morphology1.11039160
65MP0002277_abnormal_respiratory_mucosa1.08575517
66MP0001851_eye_inflammation1.06475031
67MP0004510_myositis1.03917784
68MP0009763_increased_sensitivity_to1.01382946
69MP0002132_abnormal_respiratory_system0.96961685
70MP0005167_abnormal_blood-brain_barrier0.95565634
71MP0000015_abnormal_ear_pigmentation0.93691724
72MP0000249_abnormal_blood_vessel0.85423399
73MP0003656_abnormal_erythrocyte_physiolo0.85358038
74MP0002396_abnormal_hematopoietic_system0.84838224
75MP0002009_preneoplasia0.84505630
76MP0002006_tumorigenesis0.83898363
77MP0001663_abnormal_digestive_system0.83767853
78MP0000920_abnormal_myelination0.83539670
79MP0000703_abnormal_thymus_morphology0.81972143
80MP0005360_urolithiasis0.80679499
81MP0005390_skeleton_phenotype0.78734956
82MP0005075_abnormal_melanosome_morpholog0.78341483
83MP0005365_abnormal_bile_salt0.74973449
84MP0001542_abnormal_bone_strength0.73659186
85MP0004381_abnormal_hair_follicle0.70733340
86MP0002139_abnormal_hepatobiliary_system0.70529781
87MP0005174_abnormal_tail_pigmentation0.70078438
88MP0001986_abnormal_taste_sensitivity0.68888409
89MP0003795_abnormal_bone_structure0.67700239
90MP0005584_abnormal_enzyme/coenzyme_acti0.61626889
91MP0005319_abnormal_enzyme/_coenzyme0.61101720
92MP0001873_stomach_inflammation0.60934310
93MP0002933_joint_inflammation0.60283925
94MP0002138_abnormal_hepatobiliary_system0.60072212
95MP0000609_abnormal_liver_physiology0.57519811
96MP0009765_abnormal_xenobiotic_induced0.56597603
97MP0002332_abnormal_exercise_endurance0.54142733
98MP0006054_spinal_hemorrhage0.53873316
99MP0009115_abnormal_fat_cell0.53195741
100MP0003329_amyloid_beta_deposits0.52164042

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.18465538
2Recurrent abscess formation (HP:0002722)6.07970330
3Eczematoid dermatitis (HP:0000976)5.56778223
4Abnormality of macrophages (HP:0004311)5.32287367
5Systemic lupus erythematosus (HP:0002725)5.13654503
6Recurrent gram-negative bacterial infections (HP:0005420)4.91571980
7Myositis (HP:0100614)4.77389778
8Abnormality of liposaccharide metabolism (HP:0010968)4.58588330
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.58588330
10Abnormality of glycolipid metabolism (HP:0010969)4.58588330
11Orchitis (HP:0100796)4.48264612
12Retrobulbar optic neuritis (HP:0100654)4.36081918
13Optic neuritis (HP:0100653)4.36081918
14Elevated erythrocyte sedimentation rate (HP:0003565)4.20913008
15Recurrent skin infections (HP:0001581)4.10781917
16Stomatitis (HP:0010280)4.07785689
17Amyloidosis (HP:0011034)3.96025568
18Mediastinal lymphadenopathy (HP:0100721)3.89395721
19Spontaneous hematomas (HP:0007420)3.85296635
20Chronic obstructive pulmonary disease (HP:0006510)3.83799529
21Obstructive lung disease (HP:0006536)3.83799529
22Increased cerebral lipofuscin (HP:0011813)3.77227895
23Recurrent fungal infections (HP:0002841)3.68890446
24Chronic mucocutaneous candidiasis (HP:0002728)3.60353705
25Recurrent cutaneous fungal infections (HP:0011370)3.60353705
26Meningitis (HP:0001287)3.57951089
27Gingivitis (HP:0000230)3.48435732
28Hemoptysis (HP:0002105)3.30550779
29Glomerulonephritis (HP:0000099)3.26168426
30Pulmonary infiltrates (HP:0002113)3.23223158
31Dysostosis multiplex (HP:0000943)3.18430272
32Keratoconjunctivitis sicca (HP:0001097)3.15636969
33Vacuolated lymphocytes (HP:0001922)3.13098582
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.12178192
35Vasculitis (HP:0002633)3.10642082
36Urticaria (HP:0001025)3.05656116
37Gastrointestinal infarctions (HP:0005244)3.03094278
38Loss of speech (HP:0002371)3.01658485
39Keratoconjunctivitis (HP:0001096)2.94631691
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.93960206
41Disinhibition (HP:0000734)2.91941471
42Encephalitis (HP:0002383)2.90757562
43Complement deficiency (HP:0004431)2.82462149
44Chest pain (HP:0100749)2.73301639
45Abnormality of complement system (HP:0005339)2.68139284
46Pustule (HP:0200039)2.67742885
47Epistaxis (HP:0000421)2.67012553
48Pulmonary embolism (HP:0002204)2.66370202
49Recurrent viral infections (HP:0004429)2.60822585
50Gingival bleeding (HP:0000225)2.59765420
51Mutism (HP:0002300)2.59568152
52T lymphocytopenia (HP:0005403)2.56663009
53Purpura (HP:0000979)2.54044817
54Prolonged bleeding time (HP:0003010)2.53957324
55Arterial thrombosis (HP:0004420)2.49487457
56Leukocytosis (HP:0001974)2.47816602
57Abnormality of T cell number (HP:0011839)2.46576396
58Inflammation of the large intestine (HP:0002037)2.44299757
59Increased IgE level (HP:0003212)2.43938030
60Gangrene (HP:0100758)2.42989733
61Cellulitis (HP:0100658)2.39335180
62Colitis (HP:0002583)2.38701987
63Autoimmune thrombocytopenia (HP:0001973)2.38584200
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37961870
65Abnormality of polysaccharide metabolism (HP:0011012)2.37961870
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37961870
67Abnormality of the pleura (HP:0002103)2.37380429
68Petechiae (HP:0000967)2.37160895
69Increased serum ferritin (HP:0003281)2.32355741
70Gastrointestinal inflammation (HP:0004386)2.28497788
71Urinary glycosaminoglycan excretion (HP:0003541)2.27289572
72Mucopolysacchariduria (HP:0008155)2.27289572
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25850178
74Episodic fever (HP:0001954)2.22967259
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21544851
76Abnormality of the prostate (HP:0008775)2.21266755
77Polyneuropathy (HP:0001271)2.21140657
78Abnormality of iron homeostasis (HP:0011031)2.20050335
79Osteomyelitis (HP:0002754)2.18414762
80Hematochezia (HP:0002573)2.12067103
81Anorexia (HP:0002039)2.08070096
82Premature loss of primary teeth (HP:0006323)2.07284002
83Periodontitis (HP:0000704)2.07224908
84Vertigo (HP:0002321)2.06442234
85Basal ganglia calcification (HP:0002135)2.04409781
86Glomerulopathy (HP:0100820)2.03916056
87Abnormality of T cells (HP:0002843)2.01313113
88Panhypogammaglobulinemia (HP:0003139)2.01106515
89Peritonitis (HP:0002586)1.99693737
90Nephritis (HP:0000123)1.99330484
91Malnutrition (HP:0004395)1.99004242
92Hepatosplenomegaly (HP:0001433)1.98400085
93Thrombophlebitis (HP:0004418)1.93498182
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93181772
95Hypergammaglobulinemia (HP:0010702)1.91641977
96Abnormality of the peritoneum (HP:0002585)1.89322545
97Skin rash (HP:0000988)1.89090748
98Memory impairment (HP:0002354)1.89067813
99Agammaglobulinemia (HP:0004432)1.87715987
100Recurrent pneumonia (HP:0006532)1.87062095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.87200104
2BLK4.53754689
3TYK23.24511147
4MAP4K12.89260887
5FES2.77758775
6CSK2.51215121
7MAP3K142.41890967
8IRAK42.40750366
9MAP2K32.36896189
10CSF1R2.27866047
11BMPR22.24110230
12ZAP702.06965651
13TXK2.06072245
14SYK2.02966594
15ERN12.02216356
16JAK31.93593361
17MAP3K131.86687685
18KIT1.86548547
19BTK1.85568846
20TBK11.82041041
21FGR1.77938420
22TGFBR21.71061121
23PRPF4B1.69904549
24TNK21.68227466
25MAP3K31.67841574
26IKBKE1.66252752
27LYN1.64786613
28JAK11.60019795
29HCK1.54722803
30GRK61.48720151
31TAOK31.48378923
32CDK191.45969713
33TEC1.45636657
34JAK21.40272861
35GRK71.36913158
36IKBKB1.34139058
37MATK1.25750746
38LCK1.24561917
39ITK1.23006012
40TAOK11.22507343
41MAP3K111.20574559
42MAP3K11.13044416
43YES10.95610924
44PIK3CG0.91613762
45PDK10.90838500
46MARK30.90445077
47CAMKK20.87315013
48EPHB10.86698121
49IRAK10.85908496
50MOS0.78817213
51PDPK10.77767567
52STK100.76709921
53IRAK20.75938604
54MAPK70.75049811
55CDK60.73792229
56TAOK20.73397392
57SIK30.71050899
58MAPK120.69715803
59MAP3K60.69257177
60CDC42BPA0.65345657
61FYN0.62527487
62MARK20.61579729
63IRAK30.59829368
64ACVR1B0.58166723
65KSR20.52562182
66MAP3K20.51325935
67ABL10.49931055
68PRKCQ0.49137491
69LRRK20.47957926
70MAP3K50.46543683
71FGFR30.45228712
72TRPM70.43048251
73PIM10.42392097
74HIPK20.40898029
75RPS6KL10.38534474
76RPS6KC10.38534474
77MAP2K60.38421252
78SGK30.36748818
79EGFR0.36666082
80CHUK0.36163609
81RPS6KA60.34135825
82MAP3K70.33926311
83MAPKAPK20.33686056
84PTK2B0.33683230
85TESK20.31055456
86CAMK1D0.30845503
87CAMKK10.30648308
88PRKCD0.30330548
89STK110.30242449
90CDK40.30184878
91EPHA30.29807871
92DYRK1B0.28748670
93DAPK20.28181763
94SGK20.27342070
95IGF1R0.25970406
96PRKD10.24690606
97MAP2K40.24072715
98MAPK40.23408460
99PRKAA20.23378562
100ADRBK20.23152711

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.28555393
2Asthma_Homo sapiens_hsa053103.64759079
3Allograft rejection_Homo sapiens_hsa053303.50980694
4Graft-versus-host disease_Homo sapiens_hsa053323.37912120
5Leishmaniasis_Homo sapiens_hsa051403.35286921
6Autoimmune thyroid disease_Homo sapiens_hsa053203.24965737
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.75246709
8Type I diabetes mellitus_Homo sapiens_hsa049402.68974134
9Osteoclast differentiation_Homo sapiens_hsa043802.58037684
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49467795
11Tuberculosis_Homo sapiens_hsa051522.34992881
12Antigen processing and presentation_Homo sapiens_hsa046122.32179222
13Other glycan degradation_Homo sapiens_hsa005112.16167672
14Rheumatoid arthritis_Homo sapiens_hsa053232.09001687
15Viral myocarditis_Homo sapiens_hsa054162.02853288
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86331363
17Phagosome_Homo sapiens_hsa041451.81143799
18Hematopoietic cell lineage_Homo sapiens_hsa046401.77831257
19Toxoplasmosis_Homo sapiens_hsa051451.72297657
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70597235
21Lysosome_Homo sapiens_hsa041421.68269074
22Pertussis_Homo sapiens_hsa051331.61184755
23B cell receptor signaling pathway_Homo sapiens_hsa046621.58639014
24Malaria_Homo sapiens_hsa051441.54574299
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50616326
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50334013
27Influenza A_Homo sapiens_hsa051641.49909728
28Legionellosis_Homo sapiens_hsa051341.46016021
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.45963728
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.37810389
31Primary immunodeficiency_Homo sapiens_hsa053401.31222729
32Chemokine signaling pathway_Homo sapiens_hsa040621.26965968
33Herpes simplex infection_Homo sapiens_hsa051681.19479840
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15197060
35Measles_Homo sapiens_hsa051621.13253712
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12771266
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12504605
38Complement and coagulation cascades_Homo sapiens_hsa046101.07183904
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00285333
40T cell receptor signaling pathway_Homo sapiens_hsa046600.99140079
41TNF signaling pathway_Homo sapiens_hsa046680.95901982
42Salmonella infection_Homo sapiens_hsa051320.93762946
43African trypanosomiasis_Homo sapiens_hsa051430.93670351
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.92810810
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91907664
46Platelet activation_Homo sapiens_hsa046110.91343808
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87938803
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84896429
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84221615
50Acute myeloid leukemia_Homo sapiens_hsa052210.83639344
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.72081407
52Systemic lupus erythematosus_Homo sapiens_hsa053220.70323082
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64694970
54Hepatitis B_Homo sapiens_hsa051610.64602188
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62113072
56Shigellosis_Homo sapiens_hsa051310.61809853
57Amoebiasis_Homo sapiens_hsa051460.58265689
58Hepatitis C_Homo sapiens_hsa051600.57920643
59Apoptosis_Homo sapiens_hsa042100.56774332
60Collecting duct acid secretion_Homo sapiens_hsa049660.56508136
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.51814198
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51058174
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50117399
64Epstein-Barr virus infection_Homo sapiens_hsa051690.48217643
65Non-small cell lung cancer_Homo sapiens_hsa052230.43900344
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43275916
67Prion diseases_Homo sapiens_hsa050200.42765961
68Endocytosis_Homo sapiens_hsa041440.38432777
69Prolactin signaling pathway_Homo sapiens_hsa049170.38015039
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.36882336
71HTLV-I infection_Homo sapiens_hsa051660.36295299
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.36179919
73Pancreatic cancer_Homo sapiens_hsa052120.36038513
74VEGF signaling pathway_Homo sapiens_hsa043700.35706113
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35502449
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.35129423
77Dorso-ventral axis formation_Homo sapiens_hsa043200.34281599
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34198963
79Arachidonic acid metabolism_Homo sapiens_hsa005900.33147488
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33027918
81GnRH signaling pathway_Homo sapiens_hsa049120.32733103
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31548028
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31079695
84Renal cell carcinoma_Homo sapiens_hsa052110.29652110
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26393572
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26366032
87HIF-1 signaling pathway_Homo sapiens_hsa040660.24326999
88Chronic myeloid leukemia_Homo sapiens_hsa052200.22749946
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.20431002
90Renin-angiotensin system_Homo sapiens_hsa046140.20359467
91Type II diabetes mellitus_Homo sapiens_hsa049300.18779235
92Insulin resistance_Homo sapiens_hsa049310.18750796
93FoxO signaling pathway_Homo sapiens_hsa040680.18389314
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16108611
95Sphingolipid metabolism_Homo sapiens_hsa006000.15584731
96PPAR signaling pathway_Homo sapiens_hsa033200.15105814
97Choline metabolism in cancer_Homo sapiens_hsa052310.14806292
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14441310
99Regulation of autophagy_Homo sapiens_hsa041400.13864897
100Notch signaling pathway_Homo sapiens_hsa043300.13544674

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