MS4A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact7.80099139
2modulation by symbiont of host immune response (GO:0052553)7.80099139
3positive regulation by symbiont of host defense response (GO:0052509)7.80099139
4modulation by symbiont of host defense response (GO:0052031)7.80099139
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.80099139
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.80099139
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.57735356
8regulation of interferon-beta biosynthetic process (GO:0045357)6.26647191
9neutrophil activation involved in immune response (GO:0002283)6.21427621
10microglial cell activation (GO:0001774)5.98764492
11macrophage activation involved in immune response (GO:0002281)5.88998914
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.50121049
13positive regulation of interferon-alpha production (GO:0032727)5.25308306
14negative regulation of interleukin-12 production (GO:0032695)5.19748334
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.14180957
16response to host immune response (GO:0052572)5.14180957
17regulation of interferon-alpha production (GO:0032647)4.98554387
18response to peptidoglycan (GO:0032494)4.92015832
19macrophage activation (GO:0042116)4.89442247
20regulation of mononuclear cell migration (GO:0071675)4.67361767
21immunoglobulin mediated immune response (GO:0016064)4.61955401
22positive regulation of antigen processing and presentation (GO:0002579)4.57617754
23response to host (GO:0075136)4.52496075
24response to host defenses (GO:0052200)4.52496075
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.52496075
26eosinophil chemotaxis (GO:0048245)4.35646702
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26943202
28negative regulation of cell killing (GO:0031342)4.26943202
29myeloid cell activation involved in immune response (GO:0002275)4.26469493
30detection of other organism (GO:0098543)4.20407860
31granulocyte activation (GO:0036230)4.16492499
32respiratory burst (GO:0045730)4.12885037
33positive regulation of cellular amide metabolic process (GO:0034250)4.08705107
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.02393793
35neutrophil activation (GO:0042119)4.02358267
36detection of external biotic stimulus (GO:0098581)3.93375784
37regulation of B cell receptor signaling pathway (GO:0050855)3.92882628
38regulation of antigen processing and presentation (GO:0002577)3.92172361
39cellular extravasation (GO:0045123)3.89823990
40pinocytosis (GO:0006907)3.89529791
41regulation of interleukin-8 biosynthetic process (GO:0045414)3.86932311
42positive regulation of monocyte chemotaxis (GO:0090026)3.84998185
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.84871338
44eosinophil migration (GO:0072677)3.81018230
45regulation of gamma-delta T cell activation (GO:0046643)3.72940858
46detection of bacterium (GO:0016045)3.72352124
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.68679384
48detection of molecule of bacterial origin (GO:0032490)3.66052223
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62465712
50detection of biotic stimulus (GO:0009595)3.62348328
51monocyte chemotaxis (GO:0002548)3.59575213
52positive regulation of interferon-beta production (GO:0032728)3.56826559
53I-kappaB phosphorylation (GO:0007252)3.55645355
54positive regulation of mast cell activation (GO:0033005)3.55254477
55regulation of mast cell degranulation (GO:0043304)3.48675371
56negative regulation of mast cell activation (GO:0033004)3.45956129
57cellular response to thyroid hormone stimulus (GO:0097067)3.38940930
58regulation of macrophage chemotaxis (GO:0010758)3.38573526
59negative regulation of interleukin-17 production (GO:0032700)3.38481129
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35973659
61regulation of tolerance induction (GO:0002643)3.34014288
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.32459572
63positive regulation of lymphocyte migration (GO:2000403)3.32159456
64regulation of T cell tolerance induction (GO:0002664)3.31755275
65regulation of mast cell activation involved in immune response (GO:0033006)3.30924155
66response to muramyl dipeptide (GO:0032495)3.30640577
67positive regulation of mast cell degranulation (GO:0043306)3.30611091
68positive regulation of mast cell activation involved in immune response (GO:0033008)3.30611091
69positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.29761947
70regulation of mast cell activation (GO:0033003)3.29348671
71myeloid leukocyte activation (GO:0002274)3.28224663
72glycosphingolipid catabolic process (GO:0046479)3.26884153
73lymphocyte chemotaxis (GO:0048247)3.25213984
74phagocytosis, engulfment (GO:0006911)3.21242613
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.17304425
76antigen processing and presentation of endogenous antigen (GO:0019883)3.15910772
77B cell mediated immunity (GO:0019724)3.12480095
78positive regulation of type 2 immune response (GO:0002830)3.12438458
79T-helper 1 type immune response (GO:0042088)3.07417594
80superoxide anion generation (GO:0042554)3.05819626
81natural killer cell mediated immunity (GO:0002228)3.04019412
82natural killer cell mediated cytotoxicity (GO:0042267)3.04019412
83regulation of monocyte chemotaxis (GO:0090025)3.03813526
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03182175
85amino sugar catabolic process (GO:0046348)3.03055092
86cytidine catabolic process (GO:0006216)3.02620157
87cytidine deamination (GO:0009972)3.02620157
88cytidine metabolic process (GO:0046087)3.02620157
89oligosaccharide catabolic process (GO:0009313)2.99140463
90neutrophil mediated immunity (GO:0002446)2.98675010
91production of molecular mediator involved in inflammatory response (GO:0002532)2.97469637
92glycolipid catabolic process (GO:0019377)2.92165038
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91435742
94positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.90812627
95response to interferon-alpha (GO:0035455)2.90773853
96defense response to protozoan (GO:0042832)2.89968147
97positive regulation of leukocyte degranulation (GO:0043302)2.89028334
98phagosome maturation (GO:0090382)2.87911449
99regulation of hypersensitivity (GO:0002883)2.86722789
100positive regulation of chemokine secretion (GO:0090197)2.86375647
101adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.84921711
102positive regulation of gamma-delta T cell activation (GO:0046645)2.84595430
103regulation of lymphocyte chemotaxis (GO:1901623)2.83329136
104positive regulation of macrophage cytokine production (GO:0060907)2.83227663
105N-acetylneuraminate metabolic process (GO:0006054)2.82496918
106regulation of leukocyte degranulation (GO:0043300)2.82177592
107interferon-gamma-mediated signaling pathway (GO:0060333)2.81493029
108regulation of gamma-delta T cell differentiation (GO:0045586)2.80846329
109type I interferon signaling pathway (GO:0060337)2.79777787
110cellular response to type I interferon (GO:0071357)2.79777787
111hydrogen peroxide biosynthetic process (GO:0050665)2.78076249
112positive regulation of T cell migration (GO:2000406)2.78065829
113positive regulation of macrophage differentiation (GO:0045651)2.77535430
114intracellular pH reduction (GO:0051452)2.77457113
115negative regulation of granulocyte differentiation (GO:0030853)2.77061540
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76993641
117regulation of T-helper 2 cell differentiation (GO:0045628)2.76725710
118positive regulation of interleukin-1 beta secretion (GO:0050718)2.76623601
119mast cell activation (GO:0045576)2.76204124
120negative regulation of cytokine production involved in immune response (GO:0002719)2.75735119
121negative regulation of T cell mediated immunity (GO:0002710)2.75335338
122response to type I interferon (GO:0034340)2.75261258
123myeloid dendritic cell activation (GO:0001773)2.74215064
124lymphocyte mediated immunity (GO:0002449)2.74071182
125response to protozoan (GO:0001562)2.73255384
126cellular response to interferon-gamma (GO:0071346)2.72977915
127leukocyte mediated cytotoxicity (GO:0001909)2.72431726
128regulation of lymphocyte migration (GO:2000401)2.71662808
129negative regulation of interleukin-1 beta production (GO:0032691)2.71025396
130neutrophil chemotaxis (GO:0030593)2.69881725
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67123013
132granulocyte chemotaxis (GO:0071621)2.66424643
133positive regulation of interleukin-6 production (GO:0032755)2.66334500
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66168054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.73449716
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.39084388
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.15787383
4IRF8_27001747_Chip-Seq_BMDM_Mouse5.14900181
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.69824221
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.21977182
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.84291971
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53765269
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28952726
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97017203
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82614349
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57892567
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41110343
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32551931
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31024517
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25989785
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23003841
18PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.20535461
19VDR_24787735_ChIP-Seq_THP-1_Human2.19375534
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.18566791
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11008923
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99459981
23* SPI1_23547873_ChIP-Seq_NB4_Human1.94478999
24* PU_27001747_Chip-Seq_BMDM_Mouse1.86294125
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83438623
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83308178
27SCL_19346495_ChIP-Seq_HPC-7_Human1.82915676
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81933925
29SPI1_23127762_ChIP-Seq_K562_Human1.81390642
30* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69847997
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61975529
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61456685
33RUNX_20019798_ChIP-Seq_JUKART_Human1.59660269
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.53914789
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50224811
36CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47854767
37* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42622124
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.42485950
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42282981
40VDR_24763502_ChIP-Seq_THP-1_Human1.39494848
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35157246
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31031161
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29870893
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25331291
45PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24247296
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18838168
47* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17930348
48* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17511308
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16377979
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13783051
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11732438
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11600147
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10796925
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10776957
55MYB_26560356_Chip-Seq_TH2_Human1.10204301
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09057482
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08921549
58UTX_26944678_Chip-Seq_JUKART_Human1.07439262
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.06763020
60EGR1_19032775_ChIP-ChIP_M12_Human1.06613970
61GATA3_26560356_Chip-Seq_TH2_Human1.05431811
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.02836778
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01023335
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01023335
65* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99659103
66* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98910582
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98050153
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97086379
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97069796
70TCF7_22412390_ChIP-Seq_EML_Mouse0.95160529
71STAT1_20625510_ChIP-Seq_HELA_Human0.93350655
72GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93244164
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89954308
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89546005
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89063036
76LXR_22158963_ChIP-Seq_LIVER_Mouse0.88862646
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84157684
78CJUN_26792858_Chip-Seq_BT549_Human0.83632178
79GATA1_22025678_ChIP-Seq_K562_Human0.83245617
80MAF_26560356_Chip-Seq_TH2_Human0.82379841
81MAF_26560356_Chip-Seq_TH1_Human0.82089150
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80912390
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80808228
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80616295
85KDM2B_26808549_Chip-Seq_DND41_Human0.79254336
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79155345
87MYB_26560356_Chip-Seq_TH1_Human0.79128669
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78156907
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77329326
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77058608
91SOX2_20726797_ChIP-Seq_SW620_Human0.76989695
92IGF1R_20145208_ChIP-Seq_DFB_Human0.75952708
93PPARA_22158963_ChIP-Seq_LIVER_Mouse0.74018481
94RXR_22158963_ChIP-Seq_LIVER_Mouse0.73761859
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73619698
96BCL6_27268052_Chip-Seq_Bcells_Human0.73579554
97PU1_27457419_Chip-Seq_LIVER_Mouse0.72965736
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72776078
99* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72332006
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72041889
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70027459
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69814890
103GATA1_19941826_ChIP-Seq_K562_Human0.69569899
104GATA3_27048872_Chip-Seq_THYMUS_Human0.69158961
105LXR_22292898_ChIP-Seq_THP-1_Human0.69028375
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68658330
107TFEB_21752829_ChIP-Seq_HELA_Human0.68440332
108SPI1_20517297_ChIP-Seq_HL60_Human0.67925423
109SMRT_27268052_Chip-Seq_Bcells_Human0.67799785
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67425161
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66444947
112VDR_21846776_ChIP-Seq_THP-1_Human0.66032143
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.65926926
114TP53_18474530_ChIP-ChIP_U2OS_Human0.64526317
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.64365236
116GATA2_19941826_ChIP-Seq_K562_Human0.62331505
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.60656960
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.59805304
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59691610
120STAT3_18555785_Chip-Seq_ESCs_Mouse0.58267281
121TP53_16413492_ChIP-PET_HCT116_Human0.57343700
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.57087547
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57078006
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.55483267
125EGR1_19374776_ChIP-ChIP_THP-1_Human0.54925712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.99161815
2MP0001835_abnormal_antigen_presentation4.67401263
3MP0002148_abnormal_hypersensitivity_rea3.64427380
4MP0006082_CNS_inflammation3.61215488
5MP0003436_decreased_susceptibility_to3.56120270
6MP0002419_abnormal_innate_immunity3.39338719
7MP0003172_abnormal_lysosome_physiology3.24880886
8MP0005000_abnormal_immune_tolerance3.11254052
9MP0003303_peritoneal_inflammation3.01133838
10MP0009785_altered_susceptibility_to2.88256751
11MP0000569_abnormal_digit_pigmentation2.87641439
12MP0005387_immune_system_phenotype2.68102026
13MP0001790_abnormal_immune_system2.68102026
14MP0005025_abnormal_response_to2.66740061
15MP0009840_abnormal_foam_cell2.63650331
16MP0002452_abnormal_antigen_presenting2.59089056
17MP0001800_abnormal_humoral_immune2.38549569
18MP0002723_abnormal_immune_serum2.37542604
19MP0003690_abnormal_glial_cell2.31936574
20MP0002277_abnormal_respiratory_mucosa2.28033646
21MP0005671_abnormal_response_to2.23968087
22MP0003724_increased_susceptibility_to2.18375851
23MP0005464_abnormal_platelet_physiology2.14210599
24MP0001533_abnormal_skeleton_physiology2.10169371
25MP0001819_abnormal_immune_cell2.07092377
26MP0002420_abnormal_adaptive_immunity2.05343752
27MP0004510_myositis2.02650905
28MP0000604_amyloidosis1.98675396
29MP0003191_abnormal_cellular_cholesterol1.95015254
30MP0005310_abnormal_salivary_gland1.87332493
31MP0000343_altered_response_to1.85896828
32MP0000685_abnormal_immune_system1.78933252
33MP0002405_respiratory_system_inflammati1.78923357
34MP0009764_decreased_sensitivity_to1.73529799
35MP0003448_altered_tumor_morphology1.71392596
36MP0005174_abnormal_tail_pigmentation1.68359135
37MP0001845_abnormal_inflammatory_respons1.67418838
38MP0008438_abnormal_cutaneous_collagen1.64701962
39MP0002998_abnormal_bone_remodeling1.64571433
40MP0003075_altered_response_to1.64384000
41MP0008469_abnormal_protein_level1.58419331
42MP0000015_abnormal_ear_pigmentation1.53848892
43MP0004947_skin_inflammation1.36997601
44MP0008004_abnormal_stomach_pH1.33307376
45MP0000716_abnormal_immune_system1.31924521
46MP0003183_abnormal_peptide_metabolism1.31256579
47MP0005167_abnormal_blood-brain_barrier1.30914879
48MP0002254_reproductive_system_inflammat1.27037026
49MP0002139_abnormal_hepatobiliary_system1.25858466
50MP0005166_decreased_susceptibility_to1.25609793
51MP0005257_abnormal_intraocular_pressure1.25048654
52MP0005171_absent_coat_pigmentation1.20851779
53MP0003300_gastrointestinal_ulcer1.19850440
54MP0000920_abnormal_myelination1.19011129
55MP0000689_abnormal_spleen_morphology1.18110428
56MP0009278_abnormal_bone_marrow1.16395740
57MP0000858_altered_metastatic_potential1.16067229
58MP0003806_abnormal_nucleotide_metabolis1.15550312
59MP0001853_heart_inflammation1.14725662
60MP0010155_abnormal_intestine_physiology1.13294855
61MP0002398_abnormal_bone_marrow1.09736874
62MP0002933_joint_inflammation1.08702201
63MP0003828_pulmonary_edema1.07637835
64MP0000465_gastrointestinal_hemorrhage1.05832135
65MP0005390_skeleton_phenotype1.04329371
66MP0002429_abnormal_blood_cell1.03210104
67MP0008260_abnormal_autophagy1.02758749
68MP0010307_abnormal_tumor_latency1.02382866
69MP0005451_abnormal_body_composition1.01039094
70MP0005164_abnormal_response_to1.00507706
71MP0001851_eye_inflammation0.97211389
72MP0006054_spinal_hemorrhage0.93087238
73MP0000371_diluted_coat_color0.92102199
74MP0003329_amyloid_beta_deposits0.91407080
75MP0002722_abnormal_immune_system0.90867069
76MP0005365_abnormal_bile_salt0.90343581
77MP0002006_tumorigenesis0.89463498
78MP0003195_calcinosis0.89408138
79MP0004782_abnormal_surfactant_physiolog0.88131128
80MP0002166_altered_tumor_susceptibility0.86911896
81MP0009333_abnormal_splenocyte_physiolog0.85695227
82MP0000249_abnormal_blood_vessel0.84413613
83MP0002638_abnormal_pupillary_reflex0.83883861
84MP0003866_abnormal_defecation0.83372959
85MP0001663_abnormal_digestive_system0.82971955
86MP0002090_abnormal_vision0.82592869
87MP0001958_emphysema0.81204691
88MP0003795_abnormal_bone_structure0.80649736
89MP0009763_increased_sensitivity_to0.80185319
90MP0010386_abnormal_urinary_bladder0.77405708
91MP0003763_abnormal_thymus_physiology0.73931116
92MP0003634_abnormal_glial_cell0.71500155
93MP0005197_abnormal_uvea_morphology0.71012918
94MP0004883_abnormal_blood_vessel0.70485038
95MP0001542_abnormal_bone_strength0.69497358
96MP0002295_abnormal_pulmonary_circulatio0.68293976
97MP0009765_abnormal_xenobiotic_induced0.68061403
98MP0003453_abnormal_keratinocyte_physiol0.68045940
99MP0002332_abnormal_exercise_endurance0.67551502
100MP0002136_abnormal_kidney_physiology0.63980600
101MP0001545_abnormal_hematopoietic_system0.63471897
102MP0005397_hematopoietic_system_phenotyp0.63471897
103MP0002132_abnormal_respiratory_system0.63141589
104MP0003566_abnormal_cell_adhesion0.61326090
105MP0002138_abnormal_hepatobiliary_system0.60286308
106MP0000767_abnormal_smooth_muscle0.60115438
107MP0005165_increased_susceptibility_to0.60102384
108MP0005083_abnormal_biliary_tract0.59376461
109MP0005076_abnormal_cell_differentiation0.58551811
110MP0005647_abnormal_sex_gland0.57760013
111MP0003279_aneurysm0.57324215
112MP0005584_abnormal_enzyme/coenzyme_acti0.55004056
113MP0002133_abnormal_respiratory_system0.54424350
114MP0005388_respiratory_system_phenotype0.54424350
115MP0001324_abnormal_eye_pigmentation0.52712278
116MP0000609_abnormal_liver_physiology0.52649377
117MP0005319_abnormal_enzyme/_coenzyme0.52165815
118MP0003633_abnormal_nervous_system0.49213892
119MP0003656_abnormal_erythrocyte_physiolo0.48785481
120MP0003091_abnormal_cell_migration0.47855423
121MP0009697_abnormal_copulation0.47564297
122MP0001873_stomach_inflammation0.46410538
123MP0005275_abnormal_skin_tensile0.45458303

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.32165064
2Recurrent abscess formation (HP:0002722)7.07364292
3Increased cerebral lipofuscin (HP:0011813)6.20888754
4Vacuolated lymphocytes (HP:0001922)6.15230418
5Recurrent bacterial skin infections (HP:0005406)6.09109519
6Glomerulonephritis (HP:0000099)5.93182186
7Increased neuronal autofluorescent lipopigment (HP:0002074)5.66622117
8Eczematoid dermatitis (HP:0000976)5.46943112
9Abnormality of macrophages (HP:0004311)4.78083667
10Recurrent gram-negative bacterial infections (HP:0005420)4.75714727
11Disinhibition (HP:0000734)4.63906217
12Abnormality of liposaccharide metabolism (HP:0010968)4.54057060
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.54057060
14Abnormality of glycolipid metabolism (HP:0010969)4.54057060
15Axonal loss (HP:0003447)4.52715486
16Dysostosis multiplex (HP:0000943)4.43310083
17Prostate neoplasm (HP:0100787)4.06780328
18Complement deficiency (HP:0004431)4.05592611
19Thick nail (HP:0001805)3.89264959
20Gingivitis (HP:0000230)3.69090821
21Agnosia (HP:0010524)3.68128730
22Mediastinal lymphadenopathy (HP:0100721)3.64472069
23Abnormality of complement system (HP:0005339)3.62034023
24Recurrent skin infections (HP:0001581)3.49618499
25Chronic obstructive pulmonary disease (HP:0006510)3.49128360
26Obstructive lung disease (HP:0006536)3.49128360
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.46051039
28Autoimmune thrombocytopenia (HP:0001973)3.45672713
29Nephritis (HP:0000123)3.44055170
30Urinary glycosaminoglycan excretion (HP:0003541)3.39404700
31Mucopolysacchariduria (HP:0008155)3.39404700
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.38468880
33Abnormality of polysaccharide metabolism (HP:0011012)3.33459087
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33459087
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33459087
36Myositis (HP:0100614)3.32453293
37Orchitis (HP:0100796)3.31949953
38Optic neuritis (HP:0100653)3.31018796
39Retrobulbar optic neuritis (HP:0100654)3.31018796
40Stomatitis (HP:0010280)3.28844605
41Basal ganglia calcification (HP:0002135)3.19387733
42Elevated erythrocyte sedimentation rate (HP:0003565)3.10409539
43Upper motor neuron abnormality (HP:0002127)3.03905382
44Hemoptysis (HP:0002105)2.98240947
45Purpura (HP:0000979)2.81448935
46Pustule (HP:0200039)2.79813835
47Myocardial infarction (HP:0001658)2.76567715
48Recurrent fungal infections (HP:0002841)2.75894185
49Spontaneous hematomas (HP:0007420)2.72234444
50Loss of speech (HP:0002371)2.68704053
51Gastrointestinal infarctions (HP:0005244)2.65987302
52Pathologic fracture (HP:0002756)2.57829803
53Hepatosplenomegaly (HP:0001433)2.57633426
54T lymphocytopenia (HP:0005403)2.53561780
55Inappropriate behavior (HP:0000719)2.52540409
56Periodontitis (HP:0000704)2.51680732
57Urticaria (HP:0001025)2.45614384
58Recurrent viral infections (HP:0004429)2.43898025
59Encephalitis (HP:0002383)2.43434188
60Abnormality of T cell number (HP:0011839)2.39596329
61Osteomyelitis (HP:0002754)2.39514070
62Peripheral demyelination (HP:0011096)2.37677943
63Increased serum ferritin (HP:0003281)2.34149923
64Bone pain (HP:0002653)2.32586101
65Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32106417
66Progressive visual loss (HP:0000529)2.31312066
67Gingival bleeding (HP:0000225)2.30979765
68Pulmonary infiltrates (HP:0002113)2.29291907
69Pulmonary embolism (HP:0002204)2.28386485
70Epistaxis (HP:0000421)2.27762688
71Vasculitis (HP:0002633)2.27171093
72Chest pain (HP:0100749)2.26857794
73Premature loss of primary teeth (HP:0006323)2.26810115
74Recurrent pneumonia (HP:0006532)2.26072326
75Polyneuropathy (HP:0001271)2.24113666
76Gangrene (HP:0100758)2.23526834
77Prolonged bleeding time (HP:0003010)2.17253200
78Hematochezia (HP:0002573)2.14589861
79Abnormality of iron homeostasis (HP:0011031)2.07465643
80Leukocytosis (HP:0001974)2.06758702
81Vertigo (HP:0002321)2.05339988
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.05333995
83Osteolytic defects of the hand bones (HP:0009699)2.05333995
84J-shaped sella turcica (HP:0002680)2.05161075
85Abnormality of the prostate (HP:0008775)2.04947348
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.04929157
87Retinal atrophy (HP:0001105)2.04730545
88Recurrent cutaneous fungal infections (HP:0011370)2.03944468
89Chronic mucocutaneous candidiasis (HP:0002728)2.03944468
90Petechiae (HP:0000967)2.03847246
91Meningitis (HP:0001287)2.02788763
92Cellulitis (HP:0100658)2.01153758
93Global brain atrophy (HP:0002283)2.00227157
94Abnormality of the periventricular white matter (HP:0002518)1.98721486
95Hypokinesia (HP:0002375)1.98513193
96Anorexia (HP:0002039)1.98373353
97Conjunctival telangiectasia (HP:0000524)1.97836566
98Abnormality of the pleura (HP:0002103)1.94889386
99Episodic fever (HP:0001954)1.93996238
100Abnormality of the lumbar spine (HP:0100712)1.93310945
101Neurofibrillary tangles (HP:0002185)1.92453973
102Thoracic kyphosis (HP:0002942)1.91921007
103Increased CSF protein (HP:0002922)1.91086276
104Memory impairment (HP:0002354)1.90806464
105Apathy (HP:0000741)1.90260165
106Amaurosis fugax (HP:0100576)1.88262579
107Mutism (HP:0002300)1.88139622
108Keratoconjunctivitis sicca (HP:0001097)1.87468876
109Cerebral inclusion bodies (HP:0100314)1.87185149
110Personality changes (HP:0000751)1.85528797
111Progressive neurologic deterioration (HP:0002344)1.84077233
112Colitis (HP:0002583)1.82596251
113Joint hemorrhage (HP:0005261)1.80569267
114Recurrent lower respiratory tract infections (HP:0002783)1.80542415
115Inflammation of the large intestine (HP:0002037)1.80524236
116Diminished motivation (HP:0000745)1.78861210
117Eosinophilia (HP:0001880)1.76085759
118Spinal muscular atrophy (HP:0007269)1.74861167
119Supranuclear gaze palsy (HP:0000605)1.74722880
120Neuronal loss in central nervous system (HP:0002529)1.73306621
121Amyloidosis (HP:0011034)1.70781903
122Keratoconjunctivitis (HP:0001096)1.67797395
123Arterial tortuosity (HP:0005116)1.67748936
124Arterial thrombosis (HP:0004420)1.65009121
125Interstitial pulmonary disease (HP:0006530)1.64360133
126Sepsis (HP:0100806)1.64153225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.41219073
2RIPK44.06191884
3MAP3K143.69542163
4KIT3.51939496
5TYK23.28751203
6IRAK33.14015217
7IRAK43.04038912
8TBK13.03515957
9TXK2.46635465
10TGFBR22.43962825
11IKBKE2.41833775
12MAP4K12.39520338
13IKBKB2.11157463
14PBK2.04780745
15JAK11.98753589
16FES1.81281901
17TAOK31.80525046
18ACVR1B1.78526400
19GRK71.76039623
20LYN1.60345430
21CSF1R1.55198808
22SYK1.53088699
23FGR1.50510663
24JAK31.50081936
25HCK1.49767768
26ZAP701.44905285
27CSK1.44873439
28BMPR21.43685994
29NEK91.36674745
30YES11.27927543
31LCK1.24080040
32NME21.11816961
33MAP3K111.10900179
34DDR21.08068325
35ERN11.05447058
36MAP3K11.04123323
37TEC1.03970203
38PIM21.03529282
39CDC42BPA1.02594404
40MST41.02343943
41MAP3K131.02321454
42TAOK11.02214167
43BRD41.00801647
44SCYL21.00508749
45EIF2AK20.99221481
46TRPM70.94814961
47CAMK1D0.94349239
48CHUK0.94164120
49GRK60.93239169
50JAK20.90266485
51PRKCD0.87396336
52BTK0.85556478
53EGFR0.85423070
54NUAK10.83658475
55PDPK10.83003056
56TAOK20.81936078
57EPHB10.80971910
58PDK10.80232528
59MATK0.79820870
60MAP2K30.77391929
61ADRBK20.76758195
62DAPK20.74103526
63MAP3K30.72760428
64SIK20.72081954
65ERBB30.72037601
66ITK0.70883869
67ABL10.69449942
68CAMKK20.69307337
69KSR20.68217097
70CLK10.67912025
71FYN0.66201356
72BMX0.64720696
73PDK20.63813380
74PLK20.63769435
75BMPR1B0.63736105
76PIM10.63186005
77CAMK1G0.61621954
78PIK3CG0.58854306
79MST1R0.58624802
80MAP3K60.58371918
81EPHA30.58124187
82RIPK10.55164435
83PKN10.53918798
84IGF1R0.53137051
85MOS0.51178087
86TNK20.49489568
87MARK20.47842719
88ABL20.46912550
89IRAK20.46756531
90MAP3K20.46245022
91STK30.43547671
92MAP3K50.43048998
93PRPF4B0.42400385
94MARK30.41896651
95TTN0.40599663
96IRAK10.40375816
97MAP2K60.39495294
98HIPK20.39168641
99RPS6KA20.38295941
100RPS6KA40.37837794
101STK100.36951162
102FGFR30.36719041
103SGK30.36691778
104SIK30.36067999
105MAPK40.35701743
106PRKCQ0.35044198
107PRKCE0.34465121
108PAK40.34029543
109CDK60.33691769
110PRKG10.31658081
111PRKD10.31241657
112MAPK120.30901085
113SGK20.30632690
114RPS6KA60.30221111
115INSR0.29910582
116KSR10.29522437
117ARAF0.29364883
118MAPK70.29156523
119RPS6KL10.28730892
120RPS6KC10.28730892
121INSRR0.28235549
122MAPKAPK20.28057378
123TGFBR10.27609499
124CAMKK10.25392632
125PDGFRB0.25302917
126PRKG20.24916476
127SRC0.23337935

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.77148067
2Lysosome_Homo sapiens_hsa041423.57449796
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.22470212
4Other glycan degradation_Homo sapiens_hsa005112.95677973
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74721189
6Leishmaniasis_Homo sapiens_hsa051402.68054552
7Osteoclast differentiation_Homo sapiens_hsa043802.50819318
8Pertussis_Homo sapiens_hsa051332.41889155
9Phagosome_Homo sapiens_hsa041452.36969338
10Rheumatoid arthritis_Homo sapiens_hsa053232.36319581
11Tuberculosis_Homo sapiens_hsa051522.31113709
12Malaria_Homo sapiens_hsa051442.03355720
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.03106497
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96039084
15Graft-versus-host disease_Homo sapiens_hsa053321.87668407
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77322826
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77255089
18Legionellosis_Homo sapiens_hsa051341.73402935
19Measles_Homo sapiens_hsa051621.73136880
20Asthma_Homo sapiens_hsa053101.64607213
21Allograft rejection_Homo sapiens_hsa053301.61669517
22B cell receptor signaling pathway_Homo sapiens_hsa046621.59208384
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.58365085
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57495888
25Antigen processing and presentation_Homo sapiens_hsa046121.56779450
26Salmonella infection_Homo sapiens_hsa051321.54181390
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45134137
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42557996
29Complement and coagulation cascades_Homo sapiens_hsa046101.40851587
30Influenza A_Homo sapiens_hsa051641.40539675
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37020531
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36623329
33Chemokine signaling pathway_Homo sapiens_hsa040621.31732565
34Collecting duct acid secretion_Homo sapiens_hsa049661.31152493
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29880699
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.28181353
37Hematopoietic cell lineage_Homo sapiens_hsa046401.27207774
38Apoptosis_Homo sapiens_hsa042101.23957498
39Sphingolipid metabolism_Homo sapiens_hsa006001.23205417
40Toxoplasmosis_Homo sapiens_hsa051451.22058304
41Prion diseases_Homo sapiens_hsa050201.18320303
42TNF signaling pathway_Homo sapiens_hsa046681.13824566
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13623671
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05169555
45African trypanosomiasis_Homo sapiens_hsa051431.04019753
46Mineral absorption_Homo sapiens_hsa049781.00612181
47Shigellosis_Homo sapiens_hsa051310.96620699
48Herpes simplex infection_Homo sapiens_hsa051680.96002687
49Autoimmune thyroid disease_Homo sapiens_hsa053200.94115350
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.85747910
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85674479
52Type I diabetes mellitus_Homo sapiens_hsa049400.84227640
53Hepatitis C_Homo sapiens_hsa051600.83746058
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81150601
55Hepatitis B_Homo sapiens_hsa051610.76078770
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74737852
57Amoebiasis_Homo sapiens_hsa051460.71586262
58Primary immunodeficiency_Homo sapiens_hsa053400.67432625
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66743066
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.65322102
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64701949
62Caffeine metabolism_Homo sapiens_hsa002320.62859171
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.62823453
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61274531
65T cell receptor signaling pathway_Homo sapiens_hsa046600.57074382
66Endocytosis_Homo sapiens_hsa041440.55897273
67Viral myocarditis_Homo sapiens_hsa054160.54968988
68Platelet activation_Homo sapiens_hsa046110.54003569
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52362476
70Vibrio cholerae infection_Homo sapiens_hsa051100.51139106
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.49149997
72PPAR signaling pathway_Homo sapiens_hsa033200.44538454
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43809157
74Dorso-ventral axis formation_Homo sapiens_hsa043200.42944287
75Pancreatic cancer_Homo sapiens_hsa052120.42938021
76Steroid biosynthesis_Homo sapiens_hsa001000.42599202
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.41619781
78Renin-angiotensin system_Homo sapiens_hsa046140.40566210
79Type II diabetes mellitus_Homo sapiens_hsa049300.39576097
80Systemic lupus erythematosus_Homo sapiens_hsa053220.38711429
81Ether lipid metabolism_Homo sapiens_hsa005650.38097544
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37752497
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37058423
84VEGF signaling pathway_Homo sapiens_hsa043700.35364368
85Arachidonic acid metabolism_Homo sapiens_hsa005900.34423645
86Synaptic vesicle cycle_Homo sapiens_hsa047210.34150143
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33566542
88Renal cell carcinoma_Homo sapiens_hsa052110.33393013
89Chronic myeloid leukemia_Homo sapiens_hsa052200.32359510
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32133753
91Bladder cancer_Homo sapiens_hsa052190.30287884
92GnRH signaling pathway_Homo sapiens_hsa049120.29653774
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28278796
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.28172442
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28039567
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26318159
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.25568972
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24944503
99Tryptophan metabolism_Homo sapiens_hsa003800.24816692
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24299400
101Non-small cell lung cancer_Homo sapiens_hsa052230.22888408
102Acute myeloid leukemia_Homo sapiens_hsa052210.22348054
103Epstein-Barr virus infection_Homo sapiens_hsa051690.22097465
104HTLV-I infection_Homo sapiens_hsa051660.19911410
105ABC transporters_Homo sapiens_hsa020100.19253406
106HIF-1 signaling pathway_Homo sapiens_hsa040660.18860981
107Notch signaling pathway_Homo sapiens_hsa043300.18688391
108Insulin resistance_Homo sapiens_hsa049310.17594127
109Proteoglycans in cancer_Homo sapiens_hsa052050.17495347
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15617480
111Prolactin signaling pathway_Homo sapiens_hsa049170.15122725
112FoxO signaling pathway_Homo sapiens_hsa040680.14805215
113Melanoma_Homo sapiens_hsa052180.12511603
114Regulation of autophagy_Homo sapiens_hsa041400.11091169
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09168557

Most similar genes based on co-expression Upload to Enrichr

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