MS4A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.35848987
2left/right pattern formation (GO:0060972)8.16803796
3primary alcohol catabolic process (GO:0034310)7.62869762
4vitamin transmembrane transport (GO:0035461)7.39386811
5regulation of cilium movement (GO:0003352)7.24796111
6ethanol metabolic process (GO:0006067)6.52439524
7left/right axis specification (GO:0070986)6.31898613
8ventricular system development (GO:0021591)6.11025685
9microtubule bundle formation (GO:0001578)5.74557324
10intraciliary transport (GO:0042073)5.49186551
11diterpenoid biosynthetic process (GO:0016102)5.48728226
12ethanol oxidation (GO:0006069)5.25674932
13cilium organization (GO:0044782)5.22513475
14pyrimidine-containing compound transmembrane transport (GO:0072531)5.20688881
15cilium assembly (GO:0042384)5.05214371
16response to xenobiotic stimulus (GO:0009410)4.70421018
17one-carbon compound transport (GO:0019755)4.62595583
18tolerance induction (GO:0002507)4.60206194
19lung epithelium development (GO:0060428)4.49766998
20protein localization to cilium (GO:0061512)4.34260477
21negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.33192679
22sperm capacitation (GO:0048240)4.24149095
23negative regulation of T cell differentiation in thymus (GO:0033085)4.23703408
24regulation of interleukin-5 production (GO:0032674)4.23015906
25regulation of microtubule-based movement (GO:0060632)4.19855087
26negative regulation of humoral immune response (GO:0002921)4.18393654
27exogenous drug catabolic process (GO:0042738)4.16978808
28centriole assembly (GO:0098534)4.15841194
29microtubule-based movement (GO:0007018)4.10486198
30glomerular epithelial cell development (GO:0072310)4.07119867
31establishment of apical/basal cell polarity (GO:0035089)4.06272635
32negative regulation of immunoglobulin mediated immune response (GO:0002890)4.05646154
33negative regulation of B cell mediated immunity (GO:0002713)4.05646154
34cellular component assembly involved in morphogenesis (GO:0010927)4.02289896
35retinoic acid metabolic process (GO:0042573)3.89649240
36O-glycan processing (GO:0016266)3.84074005
37cell projection assembly (GO:0030031)3.82720567
38regulation of interleukin-13 production (GO:0032656)3.82020313
39positive regulation of tolerance induction (GO:0002645)3.81205811
40regulation of germinal center formation (GO:0002634)3.74493393
41primary alcohol metabolic process (GO:0034308)3.69121275
42terpenoid biosynthetic process (GO:0016114)3.65718541
43phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.64744237
44retinol metabolic process (GO:0042572)3.57731069
45cilium morphogenesis (GO:0060271)3.50550906
46drug catabolic process (GO:0042737)3.50149421
47epoxygenase P450 pathway (GO:0019373)3.46407736
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.44125944
49establishment of monopolar cell polarity (GO:0061162)3.44125944
50glutathione derivative metabolic process (GO:1901685)3.43565161
51glutathione derivative biosynthetic process (GO:1901687)3.43565161
52calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.31989505
53cytoplasmic microtubule organization (GO:0031122)3.30668733
54nucleoside diphosphate phosphorylation (GO:0006165)3.28969040
55multicellular organismal water homeostasis (GO:0050891)3.22177914
56lateral ventricle development (GO:0021670)3.13123504
57angiotensin maturation (GO:0002003)3.10643210
58excretion (GO:0007588)3.05352255
59sodium ion homeostasis (GO:0055078)3.02455828
60negative regulation of inclusion body assembly (GO:0090084)3.02250955
61hydrogen peroxide biosynthetic process (GO:0050665)2.99603604
62L-ascorbic acid metabolic process (GO:0019852)2.92412543
63regulation of tolerance induction (GO:0002643)2.91991700
64positive regulation of smoothened signaling pathway (GO:0045880)2.87880715
65carnitine metabolic process (GO:0009437)2.85463320
66microtubule depolymerization (GO:0007019)2.84170602
67establishment of planar polarity (GO:0001736)2.83636470
68establishment of tissue polarity (GO:0007164)2.83636470
69oligosaccharide biosynthetic process (GO:0009312)2.83071715
70aldehyde catabolic process (GO:0046185)2.82951662
71progesterone metabolic process (GO:0042448)2.78309496
72sphingomyelin metabolic process (GO:0006684)2.77533890
73hydrogen peroxide catabolic process (GO:0042744)2.76589224
74phosphatidylcholine biosynthetic process (GO:0006656)2.75329408
75phenol-containing compound catabolic process (GO:0019336)2.74297054
76water homeostasis (GO:0030104)2.73002144
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71386746
78drug metabolic process (GO:0017144)2.71203646
79microtubule polymerization or depolymerization (GO:0031109)2.66385973
80CDP-diacylglycerol biosynthetic process (GO:0016024)2.65829430
81protein O-linked glycosylation (GO:0006493)2.65532397
82reactive oxygen species biosynthetic process (GO:1903409)2.64460555
83glutathione metabolic process (GO:0006749)2.64220519
84neurotransmitter biosynthetic process (GO:0042136)2.61355022
85regulation of autophagic vacuole assembly (GO:2000785)2.61101248
86carnitine transmembrane transport (GO:1902603)2.56228554
87maintenance of gastrointestinal epithelium (GO:0030277)2.55090063
88carnitine transport (GO:0015879)2.53762110
89amino-acid betaine transport (GO:0015838)2.53762110
90vitamin transport (GO:0051180)2.52792368
91polyol transport (GO:0015791)2.51470532
92apical protein localization (GO:0045176)2.50760386
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47862609
94regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.44588462
95axonemal dynein complex assembly (GO:0070286)19.8061898
96cilium or flagellum-dependent cell motility (GO:0001539)17.0156031
97cilium movement (GO:0003341)14.4376570
98motile cilium assembly (GO:0044458)13.5728057
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.3009971
100epithelial cilium movement (GO:0003351)12.1787967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.03574314
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.49238604
3DROSHA_22980978_ChIP-Seq_HELA_Human3.12986025
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09581494
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.68994618
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58118341
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.57845981
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.39283741
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20251414
10ESR1_21235772_ChIP-Seq_MCF-7_Human1.94689975
11FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.94167560
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88588874
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.87762810
14SOX2_20726797_ChIP-Seq_SW620_Human1.85286095
15AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.83918139
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.82562553
17RUNX1_27514584_Chip-Seq_MCF-7_Human1.78736081
18AHR_22903824_ChIP-Seq_MCF-7_Human1.76255512
19GATA4_25053715_ChIP-Seq_YYC3_Human1.75973731
20STAT1_20625510_ChIP-Seq_HELA_Human1.73782445
21PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.69155763
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67751566
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63686506
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63510379
25SMC4_20622854_ChIP-Seq_HELA_Human1.59188282
26KLF5_25053715_ChIP-Seq_YYC3_Human1.57726036
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55756466
28FOXA1_25552417_ChIP-Seq_VCAP_Human1.55074702
29TP63_23658742_ChIP-Seq_EP156T_Human1.53284806
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50524755
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.47814499
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.47692917
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47014715
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46452834
35TP63_22573176_ChIP-Seq_HFKS_Human1.42381011
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.40555531
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39573182
38RAD21_21589869_ChIP-Seq_MESCs_Mouse1.36898719
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.35070250
40GATA1_19941826_ChIP-Seq_K562_Human1.34982820
41CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32098986
42FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30640826
43SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30013868
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29097675
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28984169
46ETV1_20927104_ChIP-Seq_GIST48_Human1.27289897
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26762168
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25172277
49PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.23746128
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.23299142
51VDR_22108803_ChIP-Seq_LS180_Human1.21785395
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.20781095
53RACK7_27058665_Chip-Seq_MCF-7_Human1.20520876
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20518222
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20333024
56TP53_18474530_ChIP-ChIP_U2OS_Human1.20155564
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20087153
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18358652
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.17886905
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17779838
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16960538
62CTCF_27219007_Chip-Seq_Bcells_Human1.15767486
63SMRT_27268052_Chip-Seq_Bcells_Human1.15444653
64PHF8_20622853_ChIP-Seq_HELA_Human1.15105958
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14559099
66GATA6_25053715_ChIP-Seq_YYC3_Human1.14553302
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.13015749
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11411003
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08916051
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08565383
71RBPJ_21746931_ChIP-Seq_IB4_Human1.08536677
72CREB1_26743006_Chip-Seq_LNCaP_Human1.07653224
73GATA2_19941826_ChIP-Seq_K562_Human1.06501809
74LXR_22292898_ChIP-Seq_THP-1_Human1.04986466
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04758939
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04240662
77CTCF_20526341_ChIP-Seq_ESCs_Human1.04025190
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03710026
79CEBPB_22108803_ChIP-Seq_LS180_Human1.03055033
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.00195012
81CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00192257
82PHF8_20622854_ChIP-Seq_HELA_Human1.00122320
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.99538503
84NFYA_21822215_ChIP-Seq_K562_Human0.99511158
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99223006
86P68_20966046_ChIP-Seq_HELA_Human0.97948748
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.96882080
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.96247584
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94668992
90P300_27268052_Chip-Seq_Bcells_Human0.94389023
91NFYB_21822215_ChIP-Seq_K562_Human0.89351930
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88194264
93SOX2_21211035_ChIP-Seq_LN229_Human0.87162152
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86985211
95BCOR_27268052_Chip-Seq_Bcells_Human0.86016418
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85351999
97TBL1_22424771_ChIP-Seq_293T_Human0.84254514
98E2F1_20622854_ChIP-Seq_HELA_Human0.83560458
99ZNF263_19887448_ChIP-Seq_K562_Human0.83107002
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82088285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.41976771
2MP0002653_abnormal_ependyma_morphology5.29516923
3MP0002132_abnormal_respiratory_system4.93172733
4MP0004043_abnormal_pH_regulation3.98914689
5MP0004019_abnormal_vitamin_homeostasis3.58327344
6MP0009780_abnormal_chondrocyte_physiolo3.50933559
7MP0002277_abnormal_respiratory_mucosa3.38228533
8MP0001984_abnormal_olfaction3.00329148
9MP0005360_urolithiasis3.00101098
10MP0010234_abnormal_vibrissa_follicle2.70146101
11MP0005623_abnormal_meninges_morphology2.55073428
12MP0001666_abnormal_nutrient_absorption2.50827499
13MP0004133_heterotaxia2.48286373
14MP0009379_abnormal_foot_pigmentation2.47298777
15MP0002139_abnormal_hepatobiliary_system2.46036558
16MP0005085_abnormal_gallbladder_physiolo2.45468174
17MP0001765_abnormal_ion_homeostasis2.29046544
18MP0005365_abnormal_bile_salt2.27627513
19MP0010155_abnormal_intestine_physiology2.25240568
20MP0004264_abnormal_extraembryonic_tissu2.25092156
21MP0008789_abnormal_olfactory_epithelium2.22439625
22MP0000566_synostosis2.17117691
23MP0010678_abnormal_skin_adnexa2.00357977
24MP0000678_abnormal_parathyroid_gland1.97257562
25MP0000383_abnormal_hair_follicle1.96013291
26MP0002909_abnormal_adrenal_gland1.78210566
27MP0005636_abnormal_mineral_homeostasis1.68442411
28MP0002168_other_aberrant_phenotype1.67074436
29MP0003878_abnormal_ear_physiology1.66260336
30MP0005377_hearing/vestibular/ear_phenot1.66260336
31MP0009643_abnormal_urine_homeostasis1.61988355
32MP0002876_abnormal_thyroid_physiology1.56632465
33MP0003183_abnormal_peptide_metabolism1.53775358
34MP0003656_abnormal_erythrocyte_physiolo1.50152726
35MP0001664_abnormal_digestion1.39256945
36MP0003866_abnormal_defecation1.38347709
37MP0005165_increased_susceptibility_to1.32504014
38MP0005499_abnormal_olfactory_system1.30781405
39MP0005394_taste/olfaction_phenotype1.30781405
40MP0005409_darkened_coat_color1.30243092
41MP0005083_abnormal_biliary_tract1.27081905
42MP0005395_other_phenotype1.25305047
43MP0002136_abnormal_kidney_physiology1.23140262
44MP0002160_abnormal_reproductive_system1.19961524
45MP0000465_gastrointestinal_hemorrhage1.17780550
46MP0002282_abnormal_trachea_morphology1.16650663
47MP0004147_increased_porphyrin_level1.16110271
48MP0001346_abnormal_lacrimal_gland1.09113447
49MP0003303_peritoneal_inflammation1.07280879
50MP0002249_abnormal_larynx_morphology1.01890476
51MP0005166_decreased_susceptibility_to0.97764105
52MP0001188_hyperpigmentation0.95329597
53MP0010329_abnormal_lipoprotein_level0.94431507
54MP0005248_abnormal_Harderian_gland0.92062216
55MP0000681_abnormal_thyroid_gland0.91187257
56MP0002098_abnormal_vibrissa_morphology0.90443497
57MP0001485_abnormal_pinna_reflex0.90022380
58MP0002734_abnormal_mechanical_nocicepti0.88248301
59MP0000477_abnormal_intestine_morphology0.84441282
60MP0001663_abnormal_digestive_system0.83704461
61MP0001849_ear_inflammation0.82613978
62MP0006082_CNS_inflammation0.79301003
63MP0005408_hypopigmentation0.74900707
64MP0003806_abnormal_nucleotide_metabolis0.74346314
65MP0005164_abnormal_response_to0.73535288
66MP0000490_abnormal_crypts_of0.71245698
67MP0002896_abnormal_bone_mineralization0.68859793
68MP0002822_catalepsy0.68559815
69MP0005332_abnormal_amino_acid0.68126761
70MP0003252_abnormal_bile_duct0.66816980
71MP0009765_abnormal_xenobiotic_induced0.66426377
72MP0004782_abnormal_surfactant_physiolog0.65042877
73MP0003075_altered_response_to0.64700240
74MP0001756_abnormal_urination0.64234402
75MP0005310_abnormal_salivary_gland0.63637009
76MP0004883_abnormal_blood_vessel0.63454551
77MP0003453_abnormal_keratinocyte_physiol0.63343792
78MP0005387_immune_system_phenotype0.63330486
79MP0001790_abnormal_immune_system0.63330486
80MP0010352_gastrointestinal_tract_polyps0.63257726
81MP0002638_abnormal_pupillary_reflex0.60326568
82MP0003718_maternal_effect0.60323798
83MP0002118_abnormal_lipid_homeostasis0.59914966
84MP0008872_abnormal_physiological_respon0.59882670
85MP0005381_digestive/alimentary_phenotyp0.59613145
86MP0005220_abnormal_exocrine_pancreas0.58639432
87MP0009763_increased_sensitivity_to0.57429710
88MP0002796_impaired_skin_barrier0.57256405
89MP0002735_abnormal_chemical_nociception0.55260872
90MP0000467_abnormal_esophagus_morphology0.53774169
91MP0002405_respiratory_system_inflammati0.51806661
92MP0003879_abnormal_hair_cell0.51408626
93MP0001944_abnormal_pancreas_morphology0.50836028
94MP0000858_altered_metastatic_potential0.50530637
95MP0009840_abnormal_foam_cell0.49934963
96MP0009642_abnormal_blood_homeostasis0.49322540
97MP0005319_abnormal_enzyme/_coenzyme0.48620653
98MP0001845_abnormal_inflammatory_respons0.48276137
99MP0003953_abnormal_hormone_level0.47556080
100MP0005389_reproductive_system_phenotype0.47220325

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.97832648
2Chronic bronchitis (HP:0004469)7.81687800
3Bronchiectasis (HP:0002110)7.41973675
4Nasal polyposis (HP:0100582)6.91187595
5Abnormality of the nasal mucosa (HP:0000433)5.80640914
6Recurrent sinusitis (HP:0011108)4.53386091
7Bronchitis (HP:0012387)4.49526496
8Chronic sinusitis (HP:0011109)4.15189510
9Infertility (HP:0000789)4.13946272
10Recurrent otitis media (HP:0000403)3.91540019
11Male infertility (HP:0003251)3.82112622
12Hyperactive renin-angiotensin system (HP:0000841)3.51870662
13Occipital encephalocele (HP:0002085)3.33483028
14Chronic otitis media (HP:0000389)3.17523095
15Pancreatic fibrosis (HP:0100732)3.02191535
16True hermaphroditism (HP:0010459)2.97447984
17Atelectasis (HP:0100750)2.95697095
18Cystic liver disease (HP:0006706)2.62829456
19Molar tooth sign on MRI (HP:0002419)2.45887756
20Abnormality of midbrain morphology (HP:0002418)2.45887756
21Pancreatic cysts (HP:0001737)2.39945134
22Nephronophthisis (HP:0000090)2.36512208
23Decreased circulating renin level (HP:0003351)2.35956950
24Chronic hepatic failure (HP:0100626)2.25514067
25Recurrent bronchitis (HP:0002837)2.21165599
26Postaxial foot polydactyly (HP:0001830)2.16087854
27Tubulointerstitial nephritis (HP:0001970)2.15643207
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3108747
29Abnormal respiratory motile cilium morphology (HP:0005938)11.0965665
30Abnormal respiratory epithelium morphology (HP:0012253)11.0965665
31Dynein arm defect of respiratory motile cilia (HP:0012255)10.8665498
32Absent/shortened dynein arms (HP:0200106)10.8665498
33Abnormal respiratory motile cilium physiology (HP:0012261)10.8414646
34Abnormal ciliary motility (HP:0012262)10.6896330
35Bell-shaped thorax (HP:0001591)1.95697544
36Renal salt wasting (HP:0000127)1.89899492
37Congenital hepatic fibrosis (HP:0002612)1.86711658
38Abnormality of the renal medulla (HP:0100957)1.83390752
39Abnormality of renin-angiotensin system (HP:0000847)1.79703713
40Hyperaldosteronism (HP:0000859)1.78112296
41Hyperkalemia (HP:0002153)1.72173651
42Male pseudohermaphroditism (HP:0000037)1.71417204
43Absent frontal sinuses (HP:0002688)1.69396032
44Anencephaly (HP:0002323)1.67872776
45Nephropathy (HP:0000112)1.61723495
46Malnutrition (HP:0004395)1.60428351
47Medial flaring of the eyebrow (HP:0010747)1.60233288
48Asplenia (HP:0001746)1.59941503
49Aplasia/Hypoplasia of the spleen (HP:0010451)1.58902011
50Aplasia/Hypoplasia of the tongue (HP:0010295)1.58893049
51Abnormality of chloride homeostasis (HP:0011422)1.56206882
52Abnormality of glutamine family amino acid metabolism (HP:0010902)1.56150352
53Furrowed tongue (HP:0000221)1.54168719
54Tubular atrophy (HP:0000092)1.49011418
55Congenital primary aphakia (HP:0007707)1.48572807
56Abnormality of monocarboxylic acid metabolism (HP:0010996)1.48375250
57Gait imbalance (HP:0002141)1.43905344
58Oculomotor apraxia (HP:0000657)1.42629104
59Hyponatremia (HP:0002902)1.39640437
60Abnormality of permanent molar morphology (HP:0011071)1.34429198
61Abnormality of the dental root (HP:0006486)1.34429198
62Taurodontia (HP:0000679)1.34429198
63Sclerocornea (HP:0000647)1.32037514
64Postaxial hand polydactyly (HP:0001162)1.30760761
65Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.30230464
66Nephrogenic diabetes insipidus (HP:0009806)1.26298579
67Short thorax (HP:0010306)1.26094794
68Abnormality of the distal phalanges of the toes (HP:0010182)1.25813582
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.25565593
70Hand muscle atrophy (HP:0009130)1.24220799
71Abnormality of molar morphology (HP:0011070)1.23637277
72Abnormality of molar (HP:0011077)1.23637277
73Flat acetabular roof (HP:0003180)1.23578384
74Fat malabsorption (HP:0002630)1.23185820
75Cone-rod dystrophy (HP:0000548)1.22979701
76Glucose intolerance (HP:0000833)1.21127769
77Median cleft lip (HP:0000161)1.20324961
78Hypotension (HP:0002615)1.19829693
79Abnormality of the dental pulp (HP:0006479)1.19775708
80Vascular calcification (HP:0004934)1.17798394
81Hypokalemic alkalosis (HP:0001949)1.15512661
82Abnormal glucose tolerance (HP:0001952)1.14748748
83Tubulointerstitial abnormality (HP:0001969)1.14210347
84Abnormality of vitamin metabolism (HP:0100508)1.10455046
85Bifid scrotum (HP:0000048)1.10169030
86Short nail (HP:0001799)1.08244633
87Stage 5 chronic kidney disease (HP:0003774)1.07962335
88Popliteal pterygium (HP:0009756)1.05782298
89Abnormality of sodium homeostasis (HP:0010931)1.05154145
90Decreased central vision (HP:0007663)1.04490061
91Poor coordination (HP:0002370)1.03826455
92Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.03819548
93Fetal akinesia sequence (HP:0001989)1.03632829
94Steatorrhea (HP:0002570)1.03536357
95Preaxial hand polydactyly (HP:0001177)1.02819361
96Abnormality of proline metabolism (HP:0010907)1.02548220
97Hydroxyprolinuria (HP:0003080)1.02548220
98Stridor (HP:0010307)1.02506866
99Abnormality of the frontal sinuses (HP:0002687)1.02134360
100Cardiovascular calcification (HP:0011915)1.00276280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.93839190
2EPHA25.26437210
3MAP3K22.32194679
4STK242.25870405
5MST1R2.25036030
6MAPKAPK32.15105929
7NME12.10129425
8SMG12.04291989
9MAPK1510.5082250
10ACVR1B1.98297759
11EEF2K1.69615758
12EPHB11.57208658
13TTK1.57149333
14MAP3K31.53115947
15CSK1.46345722
16RIPK11.39110280
17EPHA31.33581146
18BCR1.29962735
19RIPK41.27727168
20PTK2B1.24615891
21TESK11.18583612
22LRRK21.12516253
23MAP3K121.09741040
24NEK61.08895187
25ERN11.07637044
26STK101.04900122
27TRPM71.00804132
28MAP3K70.98176732
29TBK10.97197077
30PRKCI0.86456121
31ERBB20.84195609
32FER0.80779668
33TYK20.75197718
34ERBB30.74216993
35GRK60.72483640
36TLK10.71813073
37MARK20.71679410
38CAMKK10.69149646
39STK380.67357289
40TAOK10.65792200
41ICK0.64663915
42NLK0.64616895
43TRIB30.63310828
44IRAK10.62410722
45FGFR30.61997457
46PTK60.58437129
47PDPK10.57463561
48CDC42BPA0.56797504
49PRKG20.56505587
50PRKAA20.55962702
51MET0.55444918
52FGFR40.54023341
53PRKCD0.50972960
54CAMK2G0.50963537
55PNCK0.50926319
56PRKCQ0.50397825
57HIPK20.48963126
58MYLK0.48814574
59OXSR10.47600075
60BRSK20.47570066
61MAP2K20.46023289
62DYRK1B0.40867316
63PAK40.39181050
64SGK10.38995202
65STK160.37319825
66STK390.36103157
67GRK10.35637605
68LMTK20.35213295
69ZAP700.34767972
70PRKCA0.34137905
71MATK0.32621326
72MAP3K40.31428418
73FYN0.27654765
74CDK60.27236300
75SRC0.25783170
76MAP3K100.25458319
77PRKCZ0.24211099
78RPS6KB20.23430560
79INSRR0.23125528
80PDK10.23012496
81PRKACA0.22651634
82RET0.22550723
83RPS6KA20.22538218
84STK38L0.21067697
85AKT20.20629095
86ROCK20.19996560
87EPHA40.19005559
88BMPR20.18579052
89MAP2K60.18509604
90ABL10.17970211
91MAP2K40.17850141
92ROCK10.15917028
93MAP3K10.15053578
94MAPK110.14639033
95YES10.13244379
96PTK20.12673328
97CAMK2A0.12447589
98PBK0.11624348
99AURKA0.11079466
100ADRBK10.11049631

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.91031225
2Histidine metabolism_Homo sapiens_hsa003404.55413613
3Phenylalanine metabolism_Homo sapiens_hsa003604.21849408
4Chemical carcinogenesis_Homo sapiens_hsa052044.18658940
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.98159251
6Tyrosine metabolism_Homo sapiens_hsa003503.11014130
7Caffeine metabolism_Homo sapiens_hsa002322.61382234
8Retinol metabolism_Homo sapiens_hsa008302.45771461
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.40858778
10Glutathione metabolism_Homo sapiens_hsa004802.33612215
11Vitamin digestion and absorption_Homo sapiens_hsa049772.27071634
12beta-Alanine metabolism_Homo sapiens_hsa004102.24701681
13Linoleic acid metabolism_Homo sapiens_hsa005912.12383152
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93251640
15Starch and sucrose metabolism_Homo sapiens_hsa005001.68252419
16Huntingtons disease_Homo sapiens_hsa050161.67713403
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.66101603
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.59617882
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59514162
20Sphingolipid metabolism_Homo sapiens_hsa006001.58946392
21Fat digestion and absorption_Homo sapiens_hsa049751.58261472
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52612742
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52414596
24Fatty acid degradation_Homo sapiens_hsa000711.47865956
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47644308
26Renin-angiotensin system_Homo sapiens_hsa046141.41050461
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39405255
28Arachidonic acid metabolism_Homo sapiens_hsa005901.37561014
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33147672
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.30546079
31Mineral absorption_Homo sapiens_hsa049781.28311046
32ABC transporters_Homo sapiens_hsa020101.11707237
33Tight junction_Homo sapiens_hsa045301.11408158
34PPAR signaling pathway_Homo sapiens_hsa033201.04611726
35Peroxisome_Homo sapiens_hsa041461.00700302
36Protein digestion and absorption_Homo sapiens_hsa049740.99535277
37Arginine biosynthesis_Homo sapiens_hsa002200.98948917
38Fructose and mannose metabolism_Homo sapiens_hsa000510.98283010
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89364124
40Bile secretion_Homo sapiens_hsa049760.82223262
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81241812
42Arginine and proline metabolism_Homo sapiens_hsa003300.77806620
43Tryptophan metabolism_Homo sapiens_hsa003800.76565593
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.75139369
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74914454
46Glycerolipid metabolism_Homo sapiens_hsa005610.74139751
47Salivary secretion_Homo sapiens_hsa049700.68515403
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.66801575
49Hepatitis C_Homo sapiens_hsa051600.64205786
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.62791092
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58686744
52Asthma_Homo sapiens_hsa053100.58129534
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57912482
54Type I diabetes mellitus_Homo sapiens_hsa049400.56829872
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56623348
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.49720198
57Allograft rejection_Homo sapiens_hsa053300.49299380
58Circadian rhythm_Homo sapiens_hsa047100.48385244
59Pancreatic secretion_Homo sapiens_hsa049720.47927123
60Autoimmune thyroid disease_Homo sapiens_hsa053200.45434257
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.41046367
62Galactose metabolism_Homo sapiens_hsa000520.40613475
63Hematopoietic cell lineage_Homo sapiens_hsa046400.40382356
64Graft-versus-host disease_Homo sapiens_hsa053320.40068836
65Choline metabolism in cancer_Homo sapiens_hsa052310.40032760
66Cocaine addiction_Homo sapiens_hsa050300.34845003
67Insulin resistance_Homo sapiens_hsa049310.34010524
68Complement and coagulation cascades_Homo sapiens_hsa046100.33779475
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32136825
70Adherens junction_Homo sapiens_hsa045200.30842725
71Sulfur metabolism_Homo sapiens_hsa009200.30316097
72Ether lipid metabolism_Homo sapiens_hsa005650.29016058
73Metabolic pathways_Homo sapiens_hsa011000.28721872
74Notch signaling pathway_Homo sapiens_hsa043300.28590433
75Serotonergic synapse_Homo sapiens_hsa047260.24868744
76Taste transduction_Homo sapiens_hsa047420.22685242
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22611277
78Staphylococcus aureus infection_Homo sapiens_hsa051500.22282671
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22081365
80Collecting duct acid secretion_Homo sapiens_hsa049660.20605706
81Antigen processing and presentation_Homo sapiens_hsa046120.20264464
82Amphetamine addiction_Homo sapiens_hsa050310.18358495
83Fatty acid biosynthesis_Homo sapiens_hsa000610.17857211
84Amoebiasis_Homo sapiens_hsa051460.17165991
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16239475
86Folate biosynthesis_Homo sapiens_hsa007900.16030110
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15036569
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14550901
89Renin secretion_Homo sapiens_hsa049240.14201726
90Lysosome_Homo sapiens_hsa041420.13535147
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12835038
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11998912
93Butanoate metabolism_Homo sapiens_hsa006500.10703279
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09398045
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.09030312
96Thyroid hormone synthesis_Homo sapiens_hsa049180.07728995
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07257458
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.05283379
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04420951
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.04254890

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