

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.05674361 |
| 2 | nuclear pore organization (GO:0006999) | 5.65207622 |
| 3 | otic vesicle formation (GO:0030916) | 4.69755209 |
| 4 | pore complex assembly (GO:0046931) | 4.61257295 |
| 5 | regulation of helicase activity (GO:0051095) | 4.50142155 |
| 6 | DNA unwinding involved in DNA replication (GO:0006268) | 4.38491704 |
| 7 | kinetochore organization (GO:0051383) | 4.28484078 |
| 8 | kinetochore assembly (GO:0051382) | 4.20871458 |
| 9 | DNA replication initiation (GO:0006270) | 4.16483101 |
| 10 | paraxial mesoderm development (GO:0048339) | 4.03028808 |
| 11 | regulation of RNA export from nucleus (GO:0046831) | 3.85448834 |
| 12 | protein K6-linked ubiquitination (GO:0085020) | 3.84678688 |
| 13 | mitotic sister chromatid cohesion (GO:0007064) | 3.79383200 |
| 14 | DNA replication checkpoint (GO:0000076) | 3.72626132 |
| 15 | regulation of centriole replication (GO:0046599) | 3.72179198 |
| 16 | regulation of histone H3-K9 methylation (GO:0051570) | 3.71834369 |
| 17 | mitotic metaphase plate congression (GO:0007080) | 3.71741958 |
| 18 | regulation of DNA endoreduplication (GO:0032875) | 3.71238470 |
| 19 | limb bud formation (GO:0060174) | 3.70451663 |
| 20 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.66593341 |
| 21 | axon extension involved in axon guidance (GO:0048846) | 3.66593341 |
| 22 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.65020998 |
| 23 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.60441160 |
| 24 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.58943130 |
| 25 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.55336673 |
| 26 | protein localization to kinetochore (GO:0034501) | 3.48971578 |
| 27 | pre-miRNA processing (GO:0031054) | 3.44584765 |
| 28 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.43673186 |
| 29 | replication fork processing (GO:0031297) | 3.43673065 |
| 30 | intra-S DNA damage checkpoint (GO:0031573) | 3.42927980 |
| 31 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.41353742 |
| 32 | presynaptic membrane assembly (GO:0097105) | 3.40667304 |
| 33 | chromatin remodeling at centromere (GO:0031055) | 3.39174582 |
| 34 | CENP-A containing nucleosome assembly (GO:0034080) | 3.38924340 |
| 35 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.36953018 |
| 36 | centriole replication (GO:0007099) | 3.35812304 |
| 37 | forebrain neuron differentiation (GO:0021879) | 3.35417841 |
| 38 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.33819781 |
| 39 | DNA double-strand break processing (GO:0000729) | 3.28114493 |
| 40 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.27702453 |
| 41 | metaphase plate congression (GO:0051310) | 3.27598425 |
| 42 | lateral sprouting from an epithelium (GO:0060601) | 3.27173660 |
| 43 | DNA strand elongation (GO:0022616) | 3.24522857 |
| 44 | negative regulation of histone methylation (GO:0031061) | 3.24216315 |
| 45 | mitotic nuclear envelope disassembly (GO:0007077) | 3.24209293 |
| 46 | DNA replication-independent nucleosome organization (GO:0034724) | 3.24115836 |
| 47 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.24115836 |
| 48 | spindle checkpoint (GO:0031577) | 3.20313152 |
| 49 | sister chromatid segregation (GO:0000819) | 3.20224004 |
| 50 | negative regulation of DNA recombination (GO:0045910) | 3.18897878 |
| 51 | histone-serine phosphorylation (GO:0035404) | 3.17426801 |
| 52 | mitotic recombination (GO:0006312) | 3.16163851 |
| 53 | regulation of spindle organization (GO:0090224) | 3.14624769 |
| 54 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052 | 3.14431705 |
| 55 | regulation of sister chromatid cohesion (GO:0007063) | 3.12688492 |
| 56 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.12369451 |
| 57 | negative regulation of axon guidance (GO:1902668) | 3.09656104 |
| 58 | response to UV-C (GO:0010225) | 3.09637909 |
| 59 | regulation of histone H3-K27 methylation (GO:0061085) | 3.09302169 |
| 60 | mitotic spindle checkpoint (GO:0071174) | 3.09080759 |
| 61 | sister chromatid cohesion (GO:0007062) | 3.08956582 |
| 62 | retinal ganglion cell axon guidance (GO:0031290) | 3.08558570 |
| 63 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.08146418 |
| 64 | axonal fasciculation (GO:0007413) | 3.07103732 |
| 65 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.06212736 |
| 66 | presynaptic membrane organization (GO:0097090) | 3.06158507 |
| 67 | head development (GO:0060322) | 3.05762555 |
| 68 | ribosome assembly (GO:0042255) | 3.05099037 |
| 69 | negative regulation of chromosome segregation (GO:0051985) | 3.02867425 |
| 70 | nuclear envelope disassembly (GO:0051081) | 3.02762996 |
| 71 | membrane disassembly (GO:0030397) | 3.02762996 |
| 72 | histone exchange (GO:0043486) | 3.02195654 |
| 73 | regulation of centrosome cycle (GO:0046605) | 3.01240221 |
| 74 | positive regulation of chromosome segregation (GO:0051984) | 3.00431703 |
| 75 | regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) | 3.00277592 |
| 76 | negative regulation of mRNA processing (GO:0050686) | 2.99813747 |
| 77 | mitotic sister chromatid segregation (GO:0000070) | 2.99144252 |
| 78 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.98266562 |
| 79 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.98266562 |
| 80 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.98266562 |
| 81 | negative regulation of sister chromatid segregation (GO:0033046) | 2.98266562 |
| 82 | spindle assembly checkpoint (GO:0071173) | 2.98183798 |
| 83 | maturation of SSU-rRNA (GO:0030490) | 2.96266110 |
| 84 | regulation of double-strand break repair (GO:2000779) | 2.94853085 |
| 85 | mitotic spindle assembly checkpoint (GO:0007094) | 2.94770056 |
| 86 | telomere maintenance via recombination (GO:0000722) | 2.94172492 |
| 87 | mismatch repair (GO:0006298) | 2.93611801 |
| 88 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.93018092 |
| 89 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.91840611 |
| 90 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.91840611 |
| 91 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.91840611 |
| 92 | regulation of chromosome segregation (GO:0051983) | 2.91307839 |
| 93 | establishment of chromosome localization (GO:0051303) | 2.90914664 |
| 94 | telomere maintenance via telomere lengthening (GO:0010833) | 2.89623230 |
| 95 | histone H2A acetylation (GO:0043968) | 2.89289800 |
| 96 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.89247014 |
| 97 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.89226504 |
| 98 | regulation of gene silencing by miRNA (GO:0060964) | 2.89226504 |
| 99 | regulation of gene silencing by RNA (GO:0060966) | 2.89226504 |
| 100 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.89204803 |
| 101 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.89204803 |
| 102 | DNA ligation (GO:0006266) | 2.88966529 |
| 103 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 2.88700538 |
| 104 | regulation of telomere maintenance (GO:0032204) | 2.88531569 |
| 105 | primitive streak formation (GO:0090009) | 2.87895098 |
| 106 | protein localization to chromosome, centromeric region (GO:0071459) | 2.87742591 |
| 107 | positive regulation of male gonad development (GO:2000020) | 2.86537259 |
| 108 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.86167725 |
| 109 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.85617417 |
| 110 | DNA topological change (GO:0006265) | 2.85506881 |
| 111 | mitotic chromosome condensation (GO:0007076) | 2.85253408 |
| 112 | regulation of non-canonical Wnt signaling pathway (GO:2000050) | 2.83618095 |
| 113 | appendage development (GO:0048736) | 2.83594077 |
| 114 | limb development (GO:0060173) | 2.83594077 |
| 115 | heterochromatin organization (GO:0070828) | 2.83549876 |
| 116 | nonmotile primary cilium assembly (GO:0035058) | 2.83325802 |
| 117 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.81897252 |
| 118 | regulation of sister chromatid segregation (GO:0033045) | 2.81897252 |
| 119 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.81897252 |
| 120 | regulation of growth hormone secretion (GO:0060123) | 2.81604037 |
| 121 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 2.81434391 |
| 122 | microtubule depolymerization (GO:0007019) | 2.81084601 |
| 123 | protein localization to chromosome (GO:0034502) | 2.80387731 |
| 124 | somite rostral/caudal axis specification (GO:0032525) | 2.80256279 |
| 125 | intraciliary transport (GO:0042073) | 2.80140481 |
| 126 | DNA duplex unwinding (GO:0032508) | 2.79258965 |
| 127 | NLS-bearing protein import into nucleus (GO:0006607) | 2.78876417 |
| 128 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.78660955 |
| 129 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.78660955 |
| 130 | dorsal/ventral axis specification (GO:0009950) | 2.77803428 |
| 131 | DNA geometric change (GO:0032392) | 2.77436026 |
| 132 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.77248728 |
| 133 | regulation of mitotic spindle organization (GO:0060236) | 2.76498068 |
| 134 | ribosome biogenesis (GO:0042254) | 2.76157868 |
| 135 | histone arginine methylation (GO:0034969) | 2.75140418 |
| 136 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.74000417 |
| 137 | meiotic chromosome segregation (GO:0045132) | 2.73793120 |
| 138 | forebrain neuron development (GO:0021884) | 2.73784347 |
| 139 | ganglion development (GO:0061548) | 2.72820041 |
| 140 | notochord development (GO:0030903) | 2.72781224 |
| 141 | resolution of meiotic recombination intermediates (GO:0000712) | 2.72016320 |
| 142 | telomere maintenance via telomerase (GO:0007004) | 2.69431954 |
| 143 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.68268252 |
| 144 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.68093483 |
| 145 | response to X-ray (GO:0010165) | 2.66266467 |
| 146 | negative chemotaxis (GO:0050919) | 2.59071393 |
| 147 | negative regulation of G2/M transition of mitotic cell cycle (GO:0010972) | 2.58906786 |
| 148 | cerebral cortex cell migration (GO:0021795) | 2.57659728 |
| 149 | positive regulation of neuroblast proliferation (GO:0002052) | 2.56301737 |
| 150 | digestive tract morphogenesis (GO:0048546) | 2.55463695 |
| 151 | regulation of male gonad development (GO:2000018) | 2.55161221 |
| 152 | thalamus development (GO:0021794) | 2.54219403 |
| 153 | olfactory bulb development (GO:0021772) | 2.53559902 |
| 154 | somite development (GO:0061053) | 2.52350272 |
| 155 | ATP-dependent chromatin remodeling (GO:0043044) | 2.51068473 |
| 156 | neuronal stem cell maintenance (GO:0097150) | 2.50022898 |
| 157 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.49102051 |
| 158 | regulation of axon guidance (GO:1902667) | 2.45943496 |
| 159 | neuron recognition (GO:0008038) | 2.44138146 |
| 160 | regulation of development, heterochronic (GO:0040034) | 2.43819539 |
| 161 | regulation of timing of cell differentiation (GO:0048505) | 2.38914127 |
| 162 | determination of adult lifespan (GO:0008340) | 2.38286088 |
| 163 | convergent extension (GO:0060026) | 2.36877005 |
| 164 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.36294679 |
| 165 | bone trabecula formation (GO:0060346) | 2.34078577 |
| 166 | retina layer formation (GO:0010842) | 2.33623017 |
| 167 | gastrulation with mouth forming second (GO:0001702) | 2.32629606 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.62298938 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.09863601 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.37526848 |
| 4 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.46348718 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.31626364 |
| 6 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.28757361 |
| 7 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 3.16548533 |
| 8 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 3.16548533 |
| 9 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 3.16548533 |
| 10 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 3.15099902 |
| 11 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.04613400 |
| 12 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.02527609 |
| 13 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.98241611 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.88010127 |
| 15 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.76913112 |
| 16 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.73648272 |
| 17 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.47543331 |
| 18 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.43639524 |
| 19 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.33869504 |
| 20 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.28197777 |
| 21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.28035283 |
| 22 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.27835018 |
| 23 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.27046760 |
| 24 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.22927184 |
| 25 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.19255739 |
| 26 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.13488885 |
| 27 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.10681774 |
| 28 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.09808032 |
| 29 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.07863130 |
| 30 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.06878646 |
| 31 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.05194713 |
| 32 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.05053231 |
| 33 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.01320136 |
| 34 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.99278297 |
| 35 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.98836703 |
| 36 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.98001741 |
| 37 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.96076048 |
| 38 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.95780385 |
| 39 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.89037444 |
| 40 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.84911775 |
| 41 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.84742138 |
| 42 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.80168437 |
| 43 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.79762211 |
| 44 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.76504173 |
| 45 | P300_19829295_ChIP-Seq_ESCs_Human | 1.72693118 |
| 46 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.72311419 |
| 47 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.70984258 |
| 48 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.70153950 |
| 49 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.69822436 |
| 50 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.69350925 |
| 51 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.67645120 |
| 52 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.66865384 |
| 53 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.66352627 |
| 54 | VDR_22108803_ChIP-Seq_LS180_Human | 1.66110924 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.65483944 |
| 56 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.64187220 |
| 57 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.62895696 |
| 58 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.62357967 |
| 59 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.59462429 |
| 60 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.58359594 |
| 61 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.57067024 |
| 62 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.55628829 |
| 63 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.55396640 |
| 64 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.51827832 |
| 65 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.50831895 |
| 66 | FUS_26573619_Chip-Seq_HEK293_Human | 1.48609331 |
| 67 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.48340466 |
| 68 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.44987390 |
| 69 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.44449130 |
| 70 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.43809407 |
| 71 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.40932557 |
| 72 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.39819803 |
| 73 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.38040496 |
| 74 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.37850102 |
| 75 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.36963822 |
| 76 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.35984803 |
| 77 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.34752967 |
| 78 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.33846723 |
| 79 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.33724842 |
| 80 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.33638969 |
| 81 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.32715035 |
| 82 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.32138262 |
| 83 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31868245 |
| 84 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.31431123 |
| 85 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.30585162 |
| 86 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.29852343 |
| 87 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.29318263 |
| 88 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.26251005 |
| 89 | STAT3_23295773_ChIP-Seq_U87_Human | 1.25509606 |
| 90 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.25000486 |
| 91 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.24425979 |
| 92 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.24350103 |
| 93 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.23850991 |
| 94 | EWS_26573619_Chip-Seq_HEK293_Human | 1.23380514 |
| 95 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.23301926 |
| 96 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.23114497 |
| 97 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.21930754 |
| 98 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.21930754 |
| 99 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.21180093 |
| 100 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.19325468 |
| 101 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.18327935 |
| 102 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18068657 |
| 103 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17021066 |
| 104 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 1.16578318 |
| 105 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.16122575 |
| 106 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.15847461 |
| 107 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.15708871 |
| 108 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.15548206 |
| 109 | TCF4_23295773_ChIP-Seq_U87_Human | 1.15427830 |
| 110 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.15235339 |
| 111 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.14476011 |
| 112 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.11620181 |
| 113 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10877554 |
| 114 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.10871215 |
| 115 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.10303939 |
| 116 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.09888142 |
| 117 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.09795278 |
| 118 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.09051357 |
| 119 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.08575532 |
| 120 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.07944376 |
| 121 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.07654806 |
| 122 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.07627666 |
| 123 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 1.07345439 |
| 124 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.06670372 |
| 125 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.06438126 |
| 126 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.05712557 |
| 127 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.05001174 |
| 128 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.04943931 |
| 129 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.04173074 |
| 130 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.04062820 |
| 131 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.03744981 |
| 132 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.03596517 |
| 133 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.02888051 |
| 134 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.01886326 |
| 135 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01742803 |
| 136 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.00770235 |
| 137 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.00588246 |
| 138 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.00309060 |
| 139 | AR_25329375_ChIP-Seq_VCAP_Human | 0.99953989 |
| 140 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.99923527 |
| 141 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.98916131 |
| 142 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.98840441 |
| 143 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.98386888 |
| 144 | JUN_21703547_ChIP-Seq_K562_Human | 0.97668197 |
| 145 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.97368655 |
| 146 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.97142044 |
| 147 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96612673 |
| 148 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.96511772 |
| 149 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.90189743 |
| 150 | NANOG_18692474_ChIP-Seq_MESCs_Mouse | 0.89760308 |
| 151 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.89267748 |
| 152 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.87731906 |
| 153 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.87117795 |
| 154 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.86527587 |
| 155 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.85184535 |
| 156 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.82597104 |
| 157 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.82289462 |
| 158 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.82188708 |
| 159 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.81817328 |
| 160 | NANOG_16518401_ChIP-PET_MESCs_Mouse | 0.81269529 |
| 161 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80915530 |
| 162 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.80254122 |
| 163 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.79832401 |
| 164 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.79020026 |
| 165 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.78309156 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 4.50941305 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.48537591 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.17440986 |
| 4 | MP0003077_abnormal_cell_cycle | 3.10009253 |
| 5 | MP0008058_abnormal_DNA_repair | 3.07856215 |
| 6 | MP0003693_abnormal_embryo_hatching | 2.92828197 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.63055848 |
| 8 | MP0006292_abnormal_olfactory_placode | 2.55113863 |
| 9 | MP0003121_genomic_imprinting | 2.39310196 |
| 10 | MP0002102_abnormal_ear_morphology | 2.32565257 |
| 11 | MP0003787_abnormal_imprinting | 2.29019614 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.27224708 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.21274761 |
| 14 | MP0003136_yellow_coat_color | 2.12751168 |
| 15 | MP0003123_paternal_imprinting | 2.12545094 |
| 16 | MP0003890_abnormal_embryonic-extraembry | 2.04559440 |
| 17 | MP0003941_abnormal_skin_development | 2.00359597 |
| 18 | MP0010030_abnormal_orbit_morphology | 1.99640335 |
| 19 | MP0004133_heterotaxia | 1.92902251 |
| 20 | MP0002249_abnormal_larynx_morphology | 1.89002952 |
| 21 | MP0000778_abnormal_nervous_system | 1.88534878 |
| 22 | MP0001730_embryonic_growth_arrest | 1.85811834 |
| 23 | MP0008877_abnormal_DNA_methylation | 1.85642413 |
| 24 | MP0001299_abnormal_eye_distance/ | 1.83409727 |
| 25 | MP0000350_abnormal_cell_proliferation | 1.82958971 |
| 26 | MP0003937_abnormal_limbs/digits/tail_de | 1.69284047 |
| 27 | MP0001293_anophthalmia | 1.67926288 |
| 28 | MP0002084_abnormal_developmental_patter | 1.67901823 |
| 29 | MP0003119_abnormal_digestive_system | 1.66734650 |
| 30 | MP0002085_abnormal_embryonic_tissue | 1.63794343 |
| 31 | MP0010352_gastrointestinal_tract_polyps | 1.63476503 |
| 32 | MP0005380_embryogenesis_phenotype | 1.62668006 |
| 33 | MP0001672_abnormal_embryogenesis/_devel | 1.62668006 |
| 34 | MP0002396_abnormal_hematopoietic_system | 1.56875181 |
| 35 | MP0000566_synostosis | 1.54826154 |
| 36 | MP0004197_abnormal_fetal_growth/weight/ | 1.54124010 |
| 37 | MP0003315_abnormal_perineum_morphology | 1.53499829 |
| 38 | MP0000537_abnormal_urethra_morphology | 1.52933086 |
| 39 | MP0006072_abnormal_retinal_apoptosis | 1.49334594 |
| 40 | MP0001697_abnormal_embryo_size | 1.47965834 |
| 41 | MP0001188_hyperpigmentation | 1.47431187 |
| 42 | MP0003938_abnormal_ear_development | 1.45577093 |
| 43 | MP0001529_abnormal_vocalization | 1.44903720 |
| 44 | MP0002088_abnormal_embryonic_growth/wei | 1.43464282 |
| 45 | MP0003984_embryonic_growth_retardation | 1.42795566 |
| 46 | MP0000534_abnormal_ureter_morphology | 1.41850723 |
| 47 | MP0009697_abnormal_copulation | 1.40882232 |
| 48 | MP0002086_abnormal_extraembryonic_tissu | 1.39716187 |
| 49 | MP0008789_abnormal_olfactory_epithelium | 1.37388882 |
| 50 | MP0010368_abnormal_lymphatic_system | 1.36127036 |
| 51 | MP0000631_abnormal_neuroendocrine_gland | 1.35298856 |
| 52 | MP0005076_abnormal_cell_differentiation | 1.33698149 |
| 53 | MP0001286_abnormal_eye_development | 1.31636686 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.30410124 |
| 55 | MP0002277_abnormal_respiratory_mucosa | 1.30367537 |
| 56 | MP0000516_abnormal_urinary_system | 1.29627576 |
| 57 | MP0005367_renal/urinary_system_phenotyp | 1.29627576 |
| 58 | MP0000462_abnormal_digestive_system | 1.29488284 |
| 59 | MP0003122_maternal_imprinting | 1.28992395 |
| 60 | MP0005248_abnormal_Harderian_gland | 1.28018606 |
| 61 | MP0000049_abnormal_middle_ear | 1.25394768 |
| 62 | MP0002233_abnormal_nose_morphology | 1.23221569 |
| 63 | MP0005409_darkened_coat_color | 1.23100592 |
| 64 | MP0000428_abnormal_craniofacial_morphol | 1.21840207 |
| 65 | MP0003718_maternal_effect | 1.20817241 |
| 66 | MP0003935_abnormal_craniofacial_develop | 1.20783746 |
| 67 | MP0009384_cardiac_valve_regurgitation | 1.17901854 |
| 68 | MP0003786_premature_aging | 1.16353293 |
| 69 | MP0003828_pulmonary_edema | 1.16047001 |
| 70 | MP0009053_abnormal_anal_canal | 1.14747976 |
| 71 | MP0003385_abnormal_body_wall | 1.14538738 |
| 72 | MP0003861_abnormal_nervous_system | 1.14195485 |
| 73 | MP0002938_white_spotting | 1.13196898 |
| 74 | MP0001177_atelectasis | 1.12815643 |
| 75 | MP0002080_prenatal_lethality | 1.11490309 |
| 76 | MP0000383_abnormal_hair_follicle | 1.11139666 |
| 77 | MP0003755_abnormal_palate_morphology | 1.08434343 |
| 78 | MP0003878_abnormal_ear_physiology | 1.08140318 |
| 79 | MP0005377_hearing/vestibular/ear_phenot | 1.08140318 |
| 80 | MP0002210_abnormal_sex_determination | 1.06506007 |
| 81 | MP0003943_abnormal_hepatobiliary_system | 1.06130411 |
| 82 | MP0005394_taste/olfaction_phenotype | 1.05460088 |
| 83 | MP0005499_abnormal_olfactory_system | 1.05460088 |
| 84 | MP0001346_abnormal_lacrimal_gland | 1.04752893 |
| 85 | MP0001879_abnormal_lymphatic_vessel | 1.04378571 |
| 86 | MP0006138_congestive_heart_failure | 1.03666251 |
| 87 | MP0000432_abnormal_head_morphology | 1.03531934 |
| 88 | MP0009703_decreased_birth_body | 1.03469140 |
| 89 | MP0005391_vision/eye_phenotype | 0.98926319 |
| 90 | MP0002653_abnormal_ependyma_morphology | 0.96960483 |
| 91 | MP0009250_abnormal_appendicular_skeleto | 0.96949356 |
| 92 | MP0001984_abnormal_olfaction | 0.94615146 |
| 93 | MP0003942_abnormal_urinary_system | 0.94310804 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.94244407 |
| 95 | MP0002081_perinatal_lethality | 0.93923636 |
| 96 | MP0003195_calcinosis | 0.93810519 |
| 97 | MP0002111_abnormal_tail_morphology | 0.93769706 |
| 98 | MP0001485_abnormal_pinna_reflex | 0.93518064 |
| 99 | MP0001145_abnormal_male_reproductive | 0.92867212 |
| 100 | MP0003936_abnormal_reproductive_system | 0.92397794 |
| 101 | MP0002925_abnormal_cardiovascular_devel | 0.91539641 |
| 102 | MP0002751_abnormal_autonomic_nervous | 0.91273852 |
| 103 | MP0002109_abnormal_limb_morphology | 0.90795957 |
| 104 | MP0005187_abnormal_penis_morphology | 0.89253001 |
| 105 | MP0002177_abnormal_outer_ear | 0.88937998 |
| 106 | MP0002152_abnormal_brain_morphology | 0.88884428 |
| 107 | MP0002116_abnormal_craniofacial_bone | 0.87797234 |
| 108 | MP0005195_abnormal_posterior_eye | 0.87565616 |
| 109 | MP0005379_endocrine/exocrine_gland_phen | 0.87109545 |
| 110 | MP0002163_abnormal_gland_morphology | 0.85934207 |
| 111 | MP0010307_abnormal_tumor_latency | 0.84015942 |
| 112 | MP0005253_abnormal_eye_physiology | 0.82527719 |
| 113 | MP0000427_abnormal_hair_cycle | 0.82390012 |
| 114 | MP0000313_abnormal_cell_death | 0.82228599 |
| 115 | MP0008995_early_reproductive_senescence | 0.81528830 |
| 116 | MP0006276_abnormal_autonomic_nervous | 0.80752395 |
| 117 | MP0000955_abnormal_spinal_cord | 0.80463656 |
| 118 | MP0003115_abnormal_respiratory_system | 0.78109416 |
| 119 | MP0000733_abnormal_muscle_development | 0.77855187 |
| 120 | MP0000653_abnormal_sex_gland | 0.77536418 |
| 121 | MP0002282_abnormal_trachea_morphology | 0.77091109 |
| 122 | MP0005623_abnormal_meninges_morphology | 0.76769861 |
| 123 | MP0002075_abnormal_coat/hair_pigmentati | 0.76669168 |
| 124 | MP0002184_abnormal_innervation | 0.76433714 |
| 125 | MP0002127_abnormal_cardiovascular_syste | 0.76408412 |
| 126 | MP0009672_abnormal_birth_weight | 0.76343663 |
| 127 | MP0003880_abnormal_central_pattern | 0.75473668 |
| 128 | MP0005551_abnormal_eye_electrophysiolog | 0.74432126 |
| 129 | MP0002114_abnormal_axial_skeleton | 0.73461948 |
| 130 | MP0001119_abnormal_female_reproductive | 0.72475701 |
| 131 | MP0002697_abnormal_eye_size | 0.72074025 |
| 132 | MP0002092_abnormal_eye_morphology | 0.71706121 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Supernumerary spleens (HP:0009799) | 4.86604479 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 4.33728324 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.62762366 |
| 4 | Chromsome breakage (HP:0040012) | 3.57892464 |
| 5 | Medulloblastoma (HP:0002885) | 3.48432880 |
| 6 | Abnormality of the labia minora (HP:0012880) | 3.47228859 |
| 7 | Breast hypoplasia (HP:0003187) | 3.45593137 |
| 8 | Ectopic kidney (HP:0000086) | 3.31534417 |
| 9 | Volvulus (HP:0002580) | 3.31529203 |
| 10 | Colon cancer (HP:0003003) | 3.28718368 |
| 11 | Supernumerary ribs (HP:0005815) | 3.10979406 |
| 12 | Supernumerary bones of the axial skeleton (HP:0009144) | 3.00709665 |
| 13 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.89418177 |
| 14 | Absent radius (HP:0003974) | 2.89400597 |
| 15 | Hepatoblastoma (HP:0002884) | 2.87226353 |
| 16 | Sex reversal (HP:0012245) | 2.87200388 |
| 17 | Abnormal sex determination (HP:0012244) | 2.87200388 |
| 18 | Absent forearm bone (HP:0003953) | 2.82533018 |
| 19 | Aplasia involving forearm bones (HP:0009822) | 2.82533018 |
| 20 | Patellar aplasia (HP:0006443) | 2.73443733 |
| 21 | Anophthalmia (HP:0000528) | 2.73123759 |
| 22 | Meckel diverticulum (HP:0002245) | 2.71534198 |
| 23 | Pancreatic fibrosis (HP:0100732) | 2.68431766 |
| 24 | True hermaphroditism (HP:0010459) | 2.64996887 |
| 25 | Gastrointestinal atresia (HP:0002589) | 2.64341533 |
| 26 | Neoplasm of the oral cavity (HP:0100649) | 2.60317439 |
| 27 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.58559005 |
| 28 | Asplenia (HP:0001746) | 2.55706690 |
| 29 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.54672814 |
| 30 | Abnormality of the ileum (HP:0001549) | 2.53509035 |
| 31 | High anterior hairline (HP:0009890) | 2.49502212 |
| 32 | Rib fusion (HP:0000902) | 2.44923856 |
| 33 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.39286064 |
| 34 | Abnormality of chromosome stability (HP:0003220) | 2.37121214 |
| 35 | Proximal placement of thumb (HP:0009623) | 2.33895938 |
| 36 | Genital tract atresia (HP:0001827) | 2.32638258 |
| 37 | Preaxial foot polydactyly (HP:0001841) | 2.30298929 |
| 38 | Duodenal stenosis (HP:0100867) | 2.29509480 |
| 39 | Small intestinal stenosis (HP:0012848) | 2.29509480 |
| 40 | Rhabdomyosarcoma (HP:0002859) | 2.27920957 |
| 41 | Partial duplication of thumb phalanx (HP:0009944) | 2.27499747 |
| 42 | Oligodactyly (hands) (HP:0001180) | 2.25019107 |
| 43 | Horseshoe kidney (HP:0000085) | 2.24674236 |
| 44 | Deviation of the thumb (HP:0009603) | 2.22398431 |
| 45 | Septo-optic dysplasia (HP:0100842) | 2.20551215 |
| 46 | Abnormal number of incisors (HP:0011064) | 2.19939657 |
| 47 | Broad metatarsal (HP:0001783) | 2.19738089 |
| 48 | Abnormality of the preputium (HP:0100587) | 2.15775719 |
| 49 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.14831013 |
| 50 | Impulsivity (HP:0100710) | 2.14140228 |
| 51 | Aqueductal stenosis (HP:0002410) | 2.14123910 |
| 52 | Ependymoma (HP:0002888) | 2.13888118 |
| 53 | Oligodactyly (HP:0012165) | 2.12535414 |
| 54 | Esophageal atresia (HP:0002032) | 2.11801469 |
| 55 | Aplasia involving bones of the extremities (HP:0009825) | 2.09837928 |
| 56 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.09837928 |
| 57 | Aplasia of the phalanges of the hand (HP:0009802) | 2.09837928 |
| 58 | Abnormality of the middle phalanges of the toes (HP:0010183) | 2.09243755 |
| 59 | Atresia of the external auditory canal (HP:0000413) | 2.07911940 |
| 60 | Abnormality of the duodenum (HP:0002246) | 2.07101154 |
| 61 | Vaginal atresia (HP:0000148) | 2.06947155 |
| 62 | Abnormal pancreas size (HP:0012094) | 2.04851401 |
| 63 | Abnormal lung lobation (HP:0002101) | 2.03631961 |
| 64 | Reticulocytopenia (HP:0001896) | 2.03282688 |
| 65 | Increased nuchal translucency (HP:0010880) | 2.02853231 |
| 66 | Duplicated collecting system (HP:0000081) | 2.02533801 |
| 67 | Abdominal situs inversus (HP:0003363) | 2.01927728 |
| 68 | Abnormality of abdominal situs (HP:0011620) | 2.01927728 |
| 69 | Arteriovenous malformation (HP:0100026) | 2.01684048 |
| 70 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.00733327 |
| 71 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.99552067 |
| 72 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.99552067 |
| 73 | Abnormality of the 4th metacarpal (HP:0010012) | 1.98466869 |
| 74 | Abnormality of the astrocytes (HP:0100707) | 1.97708226 |
| 75 | Astrocytoma (HP:0009592) | 1.97708226 |
| 76 | Pancreatic cysts (HP:0001737) | 1.97369823 |
| 77 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.96955780 |
| 78 | Duplication of thumb phalanx (HP:0009942) | 1.96698688 |
| 79 | Anal stenosis (HP:0002025) | 1.96412902 |
| 80 | Intellectual disability, moderate (HP:0002342) | 1.95032854 |
| 81 | Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658) | 1.93896171 |
| 82 | Biliary tract neoplasm (HP:0100574) | 1.93336090 |
| 83 | Short thumb (HP:0009778) | 1.92642277 |
| 84 | Neonatal short-limb short stature (HP:0008921) | 1.92095943 |
| 85 | Partial duplication of the phalanx of hand (HP:0009999) | 1.91651867 |
| 86 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.91527256 |
| 87 | Absent/shortened dynein arms (HP:0200106) | 1.91527256 |
| 88 | Short 4th metacarpal (HP:0010044) | 1.90764727 |
| 89 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.90764727 |
| 90 | Preaxial hand polydactyly (HP:0001177) | 1.89950782 |
| 91 | Abnormality of the nasal septum (HP:0000419) | 1.89818063 |
| 92 | Gastrointestinal carcinoma (HP:0002672) | 1.89646574 |
| 93 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.89646574 |
| 94 | Neoplasm of striated muscle (HP:0009728) | 1.89461733 |
| 95 | Sloping forehead (HP:0000340) | 1.89227775 |
| 96 | Gonadotropin excess (HP:0000837) | 1.86894831 |
| 97 | Abnormality of the antihelix (HP:0009738) | 1.86767282 |
| 98 | Nephronophthisis (HP:0000090) | 1.86294100 |
| 99 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.85593061 |
| 100 | Microtia (HP:0008551) | 1.84710734 |
| 101 | Glioma (HP:0009733) | 1.83968519 |
| 102 | Bronchomalacia (HP:0002780) | 1.83850598 |
| 103 | Papillary thyroid carcinoma (HP:0002895) | 1.83694793 |
| 104 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.83543491 |
| 105 | Trigonocephaly (HP:0000243) | 1.83428928 |
| 106 | 2-3 toe syndactyly (HP:0004691) | 1.82338216 |
| 107 | Abnormality of the carotid arteries (HP:0005344) | 1.81981932 |
| 108 | Embryonal renal neoplasm (HP:0011794) | 1.81289894 |
| 109 | Coronal craniosynostosis (HP:0004440) | 1.80887936 |
| 110 | Basal cell carcinoma (HP:0002671) | 1.79428249 |
| 111 | Gastroesophageal reflux (HP:0002020) | 1.79188894 |
| 112 | Triphalangeal thumb (HP:0001199) | 1.78896439 |
| 113 | Tracheomalacia (HP:0002779) | 1.78473106 |
| 114 | Tracheoesophageal fistula (HP:0002575) | 1.78257033 |
| 115 | Absent septum pellucidum (HP:0001331) | 1.78151519 |
| 116 | Abnormality of midbrain morphology (HP:0002418) | 1.76348653 |
| 117 | Molar tooth sign on MRI (HP:0002419) | 1.76348653 |
| 118 | Short humerus (HP:0005792) | 1.76257263 |
| 119 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.75753935 |
| 120 | Skull defect (HP:0001362) | 1.75540387 |
| 121 | Adrenal hypoplasia (HP:0000835) | 1.75161911 |
| 122 | Broad thumb (HP:0011304) | 1.74720802 |
| 123 | Absent thumb (HP:0009777) | 1.74648168 |
| 124 | Abnormality of the septum pellucidum (HP:0007375) | 1.73137439 |
| 125 | Abnormality of the renal collecting system (HP:0004742) | 1.72989634 |
| 126 | Leiomyosarcoma (HP:0100243) | 1.72846672 |
| 127 | Uterine leiomyosarcoma (HP:0002891) | 1.72846672 |
| 128 | Intestinal atresia (HP:0011100) | 1.72842707 |
| 129 | Abnormal biliary tract morphology (HP:0012440) | 1.72682518 |
| 130 | Abnormality of the renal medulla (HP:0100957) | 1.72657741 |
| 131 | Cutaneous finger syndactyly (HP:0010554) | 1.72441777 |
| 132 | Hypoplastic labia majora (HP:0000059) | 1.72065141 |
| 133 | Hemivertebrae (HP:0002937) | 1.71859658 |
| 134 | Agnosia (HP:0010524) | 1.71795052 |
| 135 | Increased number of teeth (HP:0011069) | 1.71369039 |
| 136 | Megalencephaly (HP:0001355) | 1.71162582 |
| 137 | Synostosis of carpal bones (HP:0005048) | 1.71050808 |
| 138 | Broad distal phalanx of finger (HP:0009836) | 1.70617596 |
| 139 | Facial hemangioma (HP:0000329) | 1.70273701 |
| 140 | Aplasia cutis congenita (HP:0001057) | 1.69948741 |
| 141 | Narrow forehead (HP:0000341) | 1.69865227 |
| 142 | Adactyly (HP:0009776) | 1.69544964 |
| 143 | Premature graying of hair (HP:0002216) | 1.69418307 |
| 144 | Neoplasm of the small intestine (HP:0100833) | 1.69119467 |
| 145 | Prominent nose (HP:0000448) | 1.69078075 |
| 146 | Diastasis recti (HP:0001540) | 1.69074553 |
| 147 | Amaurosis fugax (HP:0100576) | 1.68831743 |
| 148 | Short hallux (HP:0010109) | 1.68789762 |
| 149 | Fibular hypoplasia (HP:0003038) | 1.68781589 |
| 150 | 11 pairs of ribs (HP:0000878) | 1.66152301 |
| 151 | Embryonal neoplasm (HP:0002898) | 1.66031961 |
| 152 | Optic nerve hypoplasia (HP:0000609) | 1.65849753 |
| 153 | Postaxial foot polydactyly (HP:0001830) | 1.64838547 |
| 154 | Short tibia (HP:0005736) | 1.63558698 |
| 155 | Cystic liver disease (HP:0006706) | 1.62785396 |
| 156 | Nephrogenic diabetes insipidus (HP:0009806) | 1.60814397 |
| 157 | Congenital primary aphakia (HP:0007707) | 1.60596044 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TIE1 | 6.58260337 |
| 2 | TNIK | 3.63057275 |
| 3 | BUB1 | 3.13496357 |
| 4 | MKNK2 | 3.11980402 |
| 5 | WEE1 | 3.09940720 |
| 6 | SRPK1 | 2.98875091 |
| 7 | CDC7 | 2.82381944 |
| 8 | CDK12 | 2.69155437 |
| 9 | MKNK1 | 2.67286580 |
| 10 | PNCK | 2.53175843 |
| 11 | CDK19 | 2.47247914 |
| 12 | PLK4 | 2.40713632 |
| 13 | WNK3 | 2.29616823 |
| 14 | TSSK6 | 2.22387774 |
| 15 | NEK2 | 2.16787691 |
| 16 | MAP4K2 | 1.94089293 |
| 17 | CDK7 | 1.84987281 |
| 18 | ICK | 1.66748536 |
| 19 | TGFBR1 | 1.66616111 |
| 20 | NME2 | 1.64842578 |
| 21 | TTK | 1.64349682 |
| 22 | BCR | 1.61566615 |
| 23 | ACVR1B | 1.61365890 |
| 24 | BRD4 | 1.55169194 |
| 25 | DYRK3 | 1.53840339 |
| 26 | NTRK2 | 1.52655964 |
| 27 | PLK3 | 1.49921945 |
| 28 | LMTK2 | 1.45556636 |
| 29 | PLK1 | 1.41916061 |
| 30 | TRIM28 | 1.41624367 |
| 31 | RPS6KA4 | 1.38305289 |
| 32 | GRK1 | 1.38003778 |
| 33 | ATR | 1.37741165 |
| 34 | MAP3K4 | 1.33392444 |
| 35 | CHEK2 | 1.32762569 |
| 36 | LATS1 | 1.32086157 |
| 37 | EPHA2 | 1.30854608 |
| 38 | EIF2AK3 | 1.27737786 |
| 39 | AKT3 | 1.27556228 |
| 40 | NEK9 | 1.22605778 |
| 41 | CHEK1 | 1.19598017 |
| 42 | SGK2 | 1.16526335 |
| 43 | CAMKK2 | 1.11321877 |
| 44 | NEK6 | 1.11310137 |
| 45 | TLK1 | 1.10730900 |
| 46 | VRK1 | 1.09367332 |
| 47 | CAMK1G | 1.06769589 |
| 48 | CAMK1D | 1.05753963 |
| 49 | TAF1 | 1.05701321 |
| 50 | PAK3 | 1.02416246 |
| 51 | AURKB | 1.01183791 |
| 52 | BRSK2 | 1.00773250 |
| 53 | LATS2 | 1.00447263 |
| 54 | STK4 | 0.99976214 |
| 55 | WNK1 | 0.99753068 |
| 56 | ATM | 0.98114707 |
| 57 | PASK | 0.97069594 |
| 58 | IRAK1 | 0.95439033 |
| 59 | CSNK1A1L | 0.93483662 |
| 60 | CDK4 | 0.91667799 |
| 61 | ERBB3 | 0.91549185 |
| 62 | ALK | 0.91162074 |
| 63 | PRKD3 | 0.90365820 |
| 64 | MELK | 0.90169784 |
| 65 | TYRO3 | 0.86067287 |
| 66 | BLK | 0.84692041 |
| 67 | PLK2 | 0.83749420 |
| 68 | STK16 | 0.81446550 |
| 69 | CDK2 | 0.80602090 |
| 70 | STK10 | 0.77550402 |
| 71 | CSNK1G3 | 0.77483718 |
| 72 | TEC | 0.76079311 |
| 73 | SGK223 | 0.75149687 |
| 74 | SGK494 | 0.75149687 |
| 75 | EPHA4 | 0.73120435 |
| 76 | CDK1 | 0.72509894 |
| 77 | FRK | 0.71728166 |
| 78 | BMX | 0.71075223 |
| 79 | CSNK1G1 | 0.70964477 |
| 80 | KSR1 | 0.69102807 |
| 81 | YES1 | 0.68021275 |
| 82 | UHMK1 | 0.67637890 |
| 83 | NTRK1 | 0.67529755 |
| 84 | BRSK1 | 0.67374247 |
| 85 | MAPK13 | 0.67327881 |
| 86 | MAP3K7 | 0.66734564 |
| 87 | CDK9 | 0.63896134 |
| 88 | MAP3K10 | 0.63870509 |
| 89 | EIF2AK2 | 0.62759652 |
| 90 | CDK8 | 0.62276311 |
| 91 | CASK | 0.61817711 |
| 92 | DYRK2 | 0.61699651 |
| 93 | SGK3 | 0.60562314 |
| 94 | STK38L | 0.59262777 |
| 95 | STK3 | 0.59257707 |
| 96 | MTOR | 0.59188446 |
| 97 | DYRK1A | 0.58978195 |
| 98 | CSNK1G2 | 0.56585828 |
| 99 | CSNK1E | 0.55482985 |
| 100 | FGFR1 | 0.55002215 |
| 101 | MAP3K8 | 0.54225984 |
| 102 | RPS6KB2 | 0.53919597 |
| 103 | STK11 | 0.53008420 |
| 104 | FGFR2 | 0.51981528 |
| 105 | NEK1 | 0.51854670 |
| 106 | MARK1 | 0.51759247 |
| 107 | PINK1 | 0.51668901 |
| 108 | CDK6 | 0.50784868 |
| 109 | PRKCE | 0.50615560 |
| 110 | NLK | 0.49952636 |
| 111 | ZAK | 0.49900633 |
| 112 | DMPK | 0.49026891 |
| 113 | CSNK1D | 0.48726754 |
| 114 | AURKA | 0.48074469 |
| 115 | EIF2AK1 | 0.47491160 |
| 116 | PIM1 | 0.47198752 |
| 117 | CCNB1 | 0.46192203 |
| 118 | SIK3 | 0.46023280 |
| 119 | PRKCI | 0.45875470 |
| 120 | MINK1 | 0.45373990 |
| 121 | WNK4 | 0.44810380 |
| 122 | CSNK2A2 | 0.44379454 |
| 123 | PRKDC | 0.43372439 |
| 124 | NUAK1 | 0.43115501 |
| 125 | EPHA3 | 0.42857219 |
| 126 | PDGFRA | 0.42464220 |
| 127 | TXK | 0.41670921 |
| 128 | MAP2K4 | 0.41627538 |
| 129 | MAPK10 | 0.40650101 |
| 130 | AKT2 | 0.39737693 |
| 131 | GSK3B | 0.39017708 |
| 132 | ERBB4 | 0.38162952 |
| 133 | EPHB2 | 0.37274787 |
| 134 | STK38 | 0.36930210 |
| 135 | MAPKAPK5 | 0.36579410 |
| 136 | CSNK2A1 | 0.36040723 |
| 137 | MAP2K7 | 0.35481128 |
| 138 | MAPK14 | 0.34683372 |
| 139 | PBK | 0.33498932 |
| 140 | BMPR1B | 0.33262631 |
| 141 | CDK3 | 0.31401201 |
| 142 | MAPK9 | 0.30271250 |
| 143 | ADRBK2 | 0.29269975 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 3.84251113 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.74040811 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.64600258 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.45771634 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.15571778 |
| 6 | RNA transport_Homo sapiens_hsa03013 | 3.07586118 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.98632251 |
| 8 | Cell cycle_Homo sapiens_hsa04110 | 2.91170702 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.90046788 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.84824239 |
| 11 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.45809244 |
| 12 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.41109595 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.35833777 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.33839212 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 2.19405589 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 2.07394793 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.05185376 |
| 18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.95174391 |
| 19 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.94472900 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.92721148 |
| 21 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.90991008 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.86989917 |
| 23 | Ribosome_Homo sapiens_hsa03010 | 1.82809903 |
| 24 | Circadian rhythm_Homo sapiens_hsa04710 | 1.75443580 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.56535438 |
| 26 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.56419710 |
| 27 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.50717928 |
| 28 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.43590406 |
| 29 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.41258805 |
| 30 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.36658258 |
| 31 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.34106173 |
| 32 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.32875847 |
| 33 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.32112154 |
| 34 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.30013058 |
| 35 | Tight junction_Homo sapiens_hsa04530 | 1.25576006 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.22977543 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.10844803 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.09375850 |
| 39 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.06595011 |
| 40 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.06149895 |
| 41 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.00496732 |
| 42 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.95726194 |
| 43 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.93549650 |
| 44 | HTLV-I infection_Homo sapiens_hsa05166 | 0.89610183 |
| 45 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88454959 |
| 46 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.87208750 |
| 47 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.85857013 |
| 48 | Proteasome_Homo sapiens_hsa03050 | 0.84587116 |
| 49 | Phototransduction_Homo sapiens_hsa04744 | 0.83816145 |
| 50 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.81831780 |
| 51 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.79273661 |
| 52 | Cocaine addiction_Homo sapiens_hsa05030 | 0.76572481 |
| 53 | Prostate cancer_Homo sapiens_hsa05215 | 0.74340438 |
| 54 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.72055902 |
| 55 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.68623757 |
| 56 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.67653453 |
| 57 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.67368774 |
| 58 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.66305040 |
| 59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.66295180 |
| 60 | Colorectal cancer_Homo sapiens_hsa05210 | 0.65903784 |
| 61 | Pathways in cancer_Homo sapiens_hsa05200 | 0.64461219 |
| 62 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.64416077 |
| 63 | Adherens junction_Homo sapiens_hsa04520 | 0.63578796 |
| 64 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.62779898 |
| 65 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.62597317 |
| 66 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.61642303 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.59062030 |
| 68 | ABC transporters_Homo sapiens_hsa02010 | 0.58785216 |
| 69 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.58611222 |
| 70 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.58542213 |
| 71 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.58360908 |
| 72 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56759330 |
| 73 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.54053853 |
| 74 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.53868697 |
| 75 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.52074304 |
| 76 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.51250377 |
| 77 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.51079115 |
| 78 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50533028 |
| 79 | Nicotine addiction_Homo sapiens_hsa05033 | 0.49266933 |
| 80 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.48625774 |
| 81 | Alcoholism_Homo sapiens_hsa05034 | 0.48528114 |
| 82 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.48124984 |
| 83 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.47999838 |
| 84 | Measles_Homo sapiens_hsa05162 | 0.47417448 |
| 85 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.46463826 |
| 86 | Melanoma_Homo sapiens_hsa05218 | 0.45010004 |
| 87 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.44028072 |
| 88 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.43073995 |
| 89 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.41184285 |
| 90 | Thyroid cancer_Homo sapiens_hsa05216 | 0.40949359 |
| 91 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.40689905 |
| 92 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.38380537 |
| 93 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.37914391 |
| 94 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37728809 |
| 95 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.36977585 |
| 96 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.36918059 |
| 97 | Allograft rejection_Homo sapiens_hsa05330 | 0.36774500 |
| 98 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.36528597 |
| 99 | Influenza A_Homo sapiens_hsa05164 | 0.36461581 |
| 100 | Gap junction_Homo sapiens_hsa04540 | 0.36393867 |
| 101 | Hepatitis B_Homo sapiens_hsa05161 | 0.36354468 |
| 102 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.36214368 |
| 103 | Huntingtons disease_Homo sapiens_hsa05016 | 0.34897449 |
| 104 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.34819222 |
| 105 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.34532363 |
| 106 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.34430134 |
| 107 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.34327302 |
| 108 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.34236816 |
| 109 | Lysine degradation_Homo sapiens_hsa00310 | 0.34097809 |
| 110 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.32848287 |
| 111 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.32707697 |
| 112 | Axon guidance_Homo sapiens_hsa04360 | 0.32518724 |
| 113 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.31759667 |
| 114 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.31695688 |
| 115 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.31058704 |
| 116 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.30908025 |
| 117 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.30810106 |
| 118 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.30646082 |
| 119 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.30298379 |
| 120 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.29734802 |
| 121 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.29367290 |
| 122 | Focal adhesion_Homo sapiens_hsa04510 | 0.28328982 |
| 123 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28262504 |
| 124 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.27536453 |
| 125 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.27467202 |
| 126 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.26629726 |
| 127 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.26086148 |
| 128 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.25912386 |
| 129 | Viral myocarditis_Homo sapiens_hsa05416 | 0.25739205 |
| 130 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.24993043 |
| 131 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.24556962 |
| 132 | Melanogenesis_Homo sapiens_hsa04916 | 0.24553097 |
| 133 | Endometrial cancer_Homo sapiens_hsa05213 | 0.24193530 |
| 134 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.23791657 |
| 135 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.23561517 |
| 136 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.21349169 |
| 137 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.20399821 |
| 138 | Long-term depression_Homo sapiens_hsa04730 | 0.19036473 |
| 139 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.18947175 |
| 140 | Hepatitis C_Homo sapiens_hsa05160 | 0.18581858 |

