ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.45668755
2	presynaptic membrane assembly (GO:0097105)	5.14875060
3	presynaptic membrane organization (GO:0097090)	5.05693715
4	nucleobase catabolic process (GO:0046113)	4.98288642
5	neuron recognition (GO:0008038)	4.46664957
6	axonal fasciculation (GO:0007413)	4.42941055
7	neuron cell-cell adhesion (GO:0007158)	4.22236948
8	postsynaptic membrane organization (GO:0001941)	4.09251589
9	cell migration in hindbrain (GO:0021535)	4.05143413
10	protein localization to synapse (GO:0035418)	3.78174425
11	establishment of mitochondrion localization (GO:0051654)	3.75588671
12	vocalization behavior (GO:0071625)	3.67270865
13	behavioral response to nicotine (GO:0035095)	3.58703096
14	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.56437946
15	retinal ganglion cell axon guidance (GO:0031290)	3.50741320
16	central nervous system projection neuron axonogenesis (GO:0021952)	3.46645283
17	neurotransmitter-gated ion channel clustering (GO:0072578)	3.43660922
18	dendritic spine morphogenesis (GO:0060997)	3.35013655
19	dendrite morphogenesis (GO:0048813)	3.27907066
20	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.26453806
21	transmission of nerve impulse (GO:0019226)	3.25934847
22	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.24334679
23	mitochondrion transport along microtubule (GO:0047497)	3.24334679
24	auditory behavior (GO:0031223)	3.22933398
25	synapse assembly (GO:0007416)	3.17931832
26	neurofilament cytoskeleton organization (GO:0060052)	3.16835522
27	axon extension (GO:0048675)	3.15947643
28	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.15848305
29	substrate-independent telencephalic tangential migration (GO:0021826)	3.15848305
30	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.13850963
31	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.12583969
32	cerebral cortex radially oriented cell migration (GO:0021799)	3.10916904
33	forebrain neuron differentiation (GO:0021879)	3.07560436
34	limb bud formation (GO:0060174)	3.05211747
35	regulation of synapse structural plasticity (GO:0051823)	3.04841087
36	positive regulation of synapse assembly (GO:0051965)	3.03317607
37	neuronal ion channel clustering (GO:0045161)	3.03057384
38	protein localization to cilium (GO:0061512)	2.98705910
39	mechanosensory behavior (GO:0007638)	2.98614818
40	olfactory bulb development (GO:0021772)	2.95079804
41	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.91218579
42	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.90772802
43	spinal cord development (GO:0021510)	2.86924029
44	neuron migration (GO:0001764)	2.86463153
45	synaptic vesicle maturation (GO:0016188)	2.84174126
46	synaptic transmission, glutamatergic (GO:0035249)	2.79733212
47	dendrite development (GO:0016358)	2.79238103
48	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.78882637
49	axon extension involved in axon guidance (GO:0048846)	2.78882637
50	adult walking behavior (GO:0007628)	2.78689637
51	gamma-aminobutyric acid transport (GO:0015812)	2.76849922
52	nonmotile primary cilium assembly (GO:0035058)	2.74765258
53	layer formation in cerebral cortex (GO:0021819)	2.68898099
54	exploration behavior (GO:0035640)	2.68361696
55	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.64532420
56	glutamate receptor signaling pathway (GO:0007215)	2.64384186
57	central nervous system neuron axonogenesis (GO:0021955)	2.63766287
58	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.62630837
59	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.62319746
60	ganglion development (GO:0061548)	2.61136301
61	neuron projection extension (GO:1990138)	2.60433176
62	short-term memory (GO:0007614)	2.58846894
63	negative regulation of axon guidance (GO:1902668)	2.58018994
64	hindbrain development (GO:0030902)	2.56836844
65	regulation of feeding behavior (GO:0060259)	2.56196535
66	response to auditory stimulus (GO:0010996)	2.55370506
67	sequestering of actin monomers (GO:0042989)	2.54640064
68	somite development (GO:0061053)	2.54587928
69	regulation of synaptic vesicle exocytosis (GO:2000300)	2.54075257
70	synapse organization (GO:0050808)	2.53216526
71	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.52306117
72	neuromuscular synaptic transmission (GO:0007274)	2.52162802
73	neuron-neuron synaptic transmission (GO:0007270)	2.51708196
74	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.51377241
75	neuronal action potential propagation (GO:0019227)	2.51196084
76	regulation of posttranscriptional gene silencing (GO:0060147)	2.50145359
77	regulation of gene silencing by miRNA (GO:0060964)	2.50145359
78	regulation of gene silencing by RNA (GO:0060966)	2.50145359
79	hippocampus development (GO:0021766)	2.49894111
80	regulation of synapse assembly (GO:0051963)	2.49112879
81	positive regulation of gastrulation (GO:2000543)	2.48929460
82	cerebral cortex cell migration (GO:0021795)	2.48895272
83	negative regulation of microtubule polymerization (GO:0031115)	2.48194942
84	atrial cardiac muscle cell action potential (GO:0086014)	2.46619318
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.43445826
86	paraxial mesoderm development (GO:0048339)	2.42770184
87	innervation (GO:0060384)	2.42485554
88	intraciliary transport (GO:0042073)	2.41651800
89	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.41160781
90	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.41160781
91	regulation of translation, ncRNA-mediated (GO:0045974)	2.41160781
92	cochlea development (GO:0090102)	2.40627200
93	locomotory exploration behavior (GO:0035641)	2.40570440
94	axonogenesis (GO:0007409)	2.39920619
95	negative regulation of axonogenesis (GO:0050771)	2.38728457
96	neural tube formation (GO:0001841)	2.37871882
97	negative regulation of axon extension (GO:0030517)	2.37309645
98	establishment of nucleus localization (GO:0040023)	2.37288597
99	negative chemotaxis (GO:0050919)	2.37124223
100	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.37105889

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.89659922
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.62369300
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.33716390
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.90266423
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.79836221
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64097533
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.50485740
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44079740
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.31111320
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.23301741
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.23144581
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22161825
13	FUS_26573619_Chip-Seq_HEK293_Human	2.15909137
14	REST_21632747_ChIP-Seq_MESCs_Mouse	2.14784045
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14427359
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10173469
17	RNF2_27304074_Chip-Seq_NSC_Mouse	2.08727269
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06961481
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.04656725
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.98867976
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98263523
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.96566483
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.96419937
24	P300_19829295_ChIP-Seq_ESCs_Human	1.94059911
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91867502
26	VDR_22108803_ChIP-Seq_LS180_Human	1.89913688
27	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.88558538
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87563867
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.85085954
30	EWS_26573619_Chip-Seq_HEK293_Human	1.81291651
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.79484640
32	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.67888117
33	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.64109122
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61515829
35	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.59955001
36	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.59955001
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.57621148
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57312510
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56811096
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56811096
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.53338447
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52929244
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52575680
44	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.52465536
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.51820289
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.51501903
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50603641
48	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.48058024
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46175551
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45520484
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43843818
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42679694
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.42637295
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41817920
55	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.40424322
56	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.39778434
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38263184
58	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.38074744
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37632582
60	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.36595618
61	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.34032435
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33838275
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30946627
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27142729
65	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.26151251
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24900026
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23411430
68	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23233377
69	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.21502105
70	AR_25329375_ChIP-Seq_VCAP_Human	1.20981870
71	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.19588825
72	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.18365960
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.18018852
74	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16982846
75	AR_21572438_ChIP-Seq_LNCaP_Human	1.14480152
76	SOX9_26525672_Chip-Seq_HEART_Mouse	1.13482860
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11480138
78	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10523838
79	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.09561370
80	STAT3_23295773_ChIP-Seq_U87_Human	1.09454603
81	JUN_21703547_ChIP-Seq_K562_Human	1.09175954
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08149583
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06013168
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05593560
85	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03310057
86	TCF4_23295773_ChIP-Seq_U87_Human	1.03011032
87	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.02985529
88	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.02882974
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02520282
90	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02405747
91	CBP_20019798_ChIP-Seq_JUKART_Human	1.02252452
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02252452
93	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.02184742
94	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.01951001
95	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01924011
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00761460
97	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.99442141
98	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.98508947
99	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.98493521
100	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.97029313

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.74369378
2	MP0000778_abnormal_nervous_system	2.97527687
3	MP0004859_abnormal_synaptic_plasticity	2.83458486
4	MP0003122_maternal_imprinting	2.69950941
5	MP0002822_catalepsy	2.68856875
6	MP0004270_analgesia	2.53734262
7	MP0005423_abnormal_somatic_nervous	2.51827752
8	MP0003787_abnormal_imprinting	2.50618934
9	MP0003890_abnormal_embryonic-extraembry	2.44998811
10	MP0003121_genomic_imprinting	2.43197197
11	MP0001529_abnormal_vocalization	2.36206438
12	MP0006292_abnormal_olfactory_placode	2.29717445
13	MP0006276_abnormal_autonomic_nervous	2.28111793
14	MP0003635_abnormal_synaptic_transmissio	2.09274583
15	MP0001188_hyperpigmentation	2.03457048
16	MP0002734_abnormal_mechanical_nocicepti	1.88806195
17	MP0000569_abnormal_digit_pigmentation	1.79835757
18	MP0000955_abnormal_spinal_cord	1.79468060
19	MP0002063_abnormal_learning/memory/cond	1.79281566
20	MP0002272_abnormal_nervous_system	1.77770757
21	MP0002184_abnormal_innervation	1.76937086
22	MP0005394_taste/olfaction_phenotype	1.72584759
23	MP0005499_abnormal_olfactory_system	1.72584759
24	MP0004133_heterotaxia	1.72066075
25	MP0002735_abnormal_chemical_nociception	1.70780698
26	MP0009046_muscle_twitch	1.67712928
27	MP0009745_abnormal_behavioral_response	1.67632525
28	MP0008877_abnormal_DNA_methylation	1.66473770
29	MP0001984_abnormal_olfaction	1.66404087
30	MP0003123_paternal_imprinting	1.65595548
31	MP0002572_abnormal_emotion/affect_behav	1.61942051
32	MP0001486_abnormal_startle_reflex	1.61100535
33	MP0002102_abnormal_ear_morphology	1.58902227
34	MP0001293_anophthalmia	1.58522993
35	MP0008789_abnormal_olfactory_epithelium	1.55121449
36	MP0000566_synostosis	1.54732988
37	MP0003119_abnormal_digestive_system	1.53484848
38	MP0002064_seizures	1.50962275
39	MP0002736_abnormal_nociception_after	1.48889353
40	MP0002751_abnormal_autonomic_nervous	1.48551761
41	MP0002557_abnormal_social/conspecific_i	1.48029447
42	MP0001968_abnormal_touch/_nociception	1.47292534
43	MP0004811_abnormal_neuron_physiology	1.45205364
44	MP0002882_abnormal_neuron_morphology	1.42639938
45	MP0000631_abnormal_neuroendocrine_gland	1.41017888
46	MP0003861_abnormal_nervous_system	1.40173471
47	MP0005187_abnormal_penis_morphology	1.39323933
48	MP0004885_abnormal_endolymph	1.35930858
49	MP0004742_abnormal_vestibular_system	1.35052452
50	MP0002752_abnormal_somatic_nervous	1.34910600
51	MP0002938_white_spotting	1.34904283
52	MP0002067_abnormal_sensory_capabilities	1.32214392
53	MP0003136_yellow_coat_color	1.31936736
54	MP0002152_abnormal_brain_morphology	1.31487839
55	MP0003937_abnormal_limbs/digits/tail_de	1.31269881
56	MP0004142_abnormal_muscle_tone	1.27431977
57	MP0001970_abnormal_pain_threshold	1.27299679
58	MP0001299_abnormal_eye_distance/	1.26900066
59	MP0002233_abnormal_nose_morphology	1.26367686
60	MP0000049_abnormal_middle_ear	1.24874000
61	MP0003567_abnormal_fetal_cardiomyocyte	1.22952642
62	MP0002733_abnormal_thermal_nociception	1.20635284
63	MP0006072_abnormal_retinal_apoptosis	1.20361132
64	MP0002234_abnormal_pharynx_morphology	1.20206547
65	MP0002638_abnormal_pupillary_reflex	1.19867773
66	MP0002653_abnormal_ependyma_morphology	1.18970109
67	MP0004924_abnormal_behavior	1.18163201
68	MP0005386_behavior/neurological_phenoty	1.18163201
69	MP0001286_abnormal_eye_development	1.17264409
70	MP0003315_abnormal_perineum_morphology	1.17097339
71	MP0005551_abnormal_eye_electrophysiolog	1.15344306
72	MP0001485_abnormal_pinna_reflex	1.13167589
73	MP0003938_abnormal_ear_development	1.11087090
74	MP0010030_abnormal_orbit_morphology	1.10013782
75	MP0003283_abnormal_digestive_organ	1.07669977
76	MP0002697_abnormal_eye_size	1.07389377
77	MP0001440_abnormal_grooming_behavior	1.06880503
78	MP0008995_early_reproductive_senescence	1.01689196
79	MP0005195_abnormal_posterior_eye	1.00219544
80	MP0000026_abnormal_inner_ear	0.99658604
81	MP0005253_abnormal_eye_physiology	0.98996112
82	MP0003755_abnormal_palate_morphology	0.94807381
83	MP0002066_abnormal_motor_capabilities/c	0.93199505
84	MP0002081_perinatal_lethality	0.89007190
85	MP0003942_abnormal_urinary_system	0.87173727
86	MP0001905_abnormal_dopamine_level	0.86325590
87	MP0005645_abnormal_hypothalamus_physiol	0.85966775
88	MP0003385_abnormal_body_wall	0.85164967
89	MP0005391_vision/eye_phenotype	0.84962868
90	MP0000537_abnormal_urethra_morphology	0.82572453
91	MP0000647_abnormal_sebaceous_gland	0.80072599
92	MP0001963_abnormal_hearing_physiology	0.78507292
93	MP0000534_abnormal_ureter_morphology	0.78465206
94	MP0001177_atelectasis	0.77302331
95	MP0009379_abnormal_foot_pigmentation	0.71967018
96	MP0002069_abnormal_eating/drinking_beha	0.71514602
97	MP0002909_abnormal_adrenal_gland	0.70958064
98	MP0003935_abnormal_craniofacial_develop	0.70520295
99	MP0004145_abnormal_muscle_electrophysio	0.69226828
100	MP0005248_abnormal_Harderian_gland	0.66112848

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	3.84261582
2	Myokymia (HP:0002411)	3.72919861
3	Focal motor seizures (HP:0011153)	3.16889051
4	Cortical dysplasia (HP:0002539)	3.15055944
5	Abnormality of the labia minora (HP:0012880)	3.06219019
6	Drooling (HP:0002307)	3.04549192
7	Hepatoblastoma (HP:0002884)	2.82865420
8	Polyphagia (HP:0002591)	2.81839259
9	Focal seizures (HP:0007359)	2.78967206
10	Abnormality of the corticospinal tract (HP:0002492)	2.77822987
11	Septo-optic dysplasia (HP:0100842)	2.74502991
12	Excessive salivation (HP:0003781)	2.74061362
13	Gait imbalance (HP:0002141)	2.62841257
14	Lissencephaly (HP:0001339)	2.61739380
15	Optic nerve hypoplasia (HP:0000609)	2.58513219
16	Impaired vibration sensation in the lower limbs (HP:0002166)	2.55034034
17	Nephronophthisis (HP:0000090)	2.52395232
18	Molar tooth sign on MRI (HP:0002419)	2.47325968
19	Abnormality of midbrain morphology (HP:0002418)	2.47325968
20	Broad-based gait (HP:0002136)	2.45916515
21	Genital tract atresia (HP:0001827)	2.39278855
22	Vaginal atresia (HP:0000148)	2.37144146
23	Colon cancer (HP:0003003)	2.35340755
24	Intestinal atresia (HP:0011100)	2.34902498
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.33537606
26	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.32512300
27	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.32512300
28	Pancreatic fibrosis (HP:0100732)	2.31212025
29	Medial flaring of the eyebrow (HP:0010747)	2.27961570
30	Progressive cerebellar ataxia (HP:0002073)	2.27645595
31	Atonic seizures (HP:0010819)	2.27564338
32	Volvulus (HP:0002580)	2.23067984
33	Pachygyria (HP:0001302)	2.22330228
34	Epileptic encephalopathy (HP:0200134)	2.21714135
35	Agitation (HP:0000713)	2.21638579
36	Retinal dysplasia (HP:0007973)	2.21400606
37	Amyotrophic lateral sclerosis (HP:0007354)	2.20618113
38	Anophthalmia (HP:0000528)	2.18554091
39	Congenital primary aphakia (HP:0007707)	2.17547431
40	Febrile seizures (HP:0002373)	2.17184611
41	Hyperventilation (HP:0002883)	2.13246337
42	True hermaphroditism (HP:0010459)	2.07635156
43	Nephrogenic diabetes insipidus (HP:0009806)	2.05540892
44	Urinary urgency (HP:0000012)	2.05394848
45	Stenosis of the external auditory canal (HP:0000402)	2.04228491
46	Abnormality of the renal medulla (HP:0100957)	2.03716945
47	Specific learning disability (HP:0001328)	2.03209734
48	Dialeptic seizures (HP:0011146)	2.01630899
49	Bifid tongue (HP:0010297)	2.00859169
50	Hypoplasia of the brainstem (HP:0002365)	2.00529110
51	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.00529110
52	Chronic hepatic failure (HP:0100626)	1.98441005
53	Absent septum pellucidum (HP:0001331)	1.98069438
54	Cutaneous finger syndactyly (HP:0010554)	1.97026101
55	Bilateral microphthalmos (HP:0007633)	1.96354190
56	Absent speech (HP:0001344)	1.96192512
57	Renal hypoplasia (HP:0000089)	1.94485010
58	Failure to thrive in infancy (HP:0001531)	1.94211699
59	Narrow forehead (HP:0000341)	1.92898232
60	Urinary bladder sphincter dysfunction (HP:0002839)	1.92764349
61	Generalized tonic-clonic seizures (HP:0002069)	1.89895346
62	Labial hypoplasia (HP:0000066)	1.88888145
63	Pancreatic cysts (HP:0001737)	1.88732895
64	Postaxial hand polydactyly (HP:0001162)	1.88368616
65	Micropenis (HP:0000054)	1.87726481
66	Pendular nystagmus (HP:0012043)	1.86454864
67	Abnormality of the lower motor neuron (HP:0002366)	1.85897920
68	Morphological abnormality of the pyramidal tract (HP:0002062)	1.84651870
69	Protruding tongue (HP:0010808)	1.83830117
70	Oligodactyly (hands) (HP:0001180)	1.83257140
71	Hyperglycinemia (HP:0002154)	1.80887940
72	Spastic tetraplegia (HP:0002510)	1.77736353
73	Growth hormone deficiency (HP:0000824)	1.77234267
74	Amblyopia (HP:0000646)	1.77217161
75	Hypoplastic female external genitalia (HP:0012815)	1.76640707
76	Inability to walk (HP:0002540)	1.75641994
77	Split foot (HP:0001839)	1.75612324
78	Exotropia (HP:0000577)	1.74868510
79	Cutaneous syndactyly (HP:0012725)	1.74181703
80	Poor suck (HP:0002033)	1.73799580
81	Sclerocornea (HP:0000647)	1.73695669
82	Scrotal hypoplasia (HP:0000046)	1.73220784
83	Abnormality of the septum pellucidum (HP:0007375)	1.71990694
84	Genetic anticipation (HP:0003743)	1.71901218
85	Anencephaly (HP:0002323)	1.71030639
86	Gastrointestinal atresia (HP:0002589)	1.70577015
87	Broad foot (HP:0001769)	1.70116399
88	Chorioretinal coloboma (HP:0000567)	1.69318726
89	Abnormal eating behavior (HP:0100738)	1.68587486
90	Poor coordination (HP:0002370)	1.68460500
91	Rib fusion (HP:0000902)	1.67797787
92	Absent eyebrow (HP:0002223)	1.67562405
93	Hypsarrhythmia (HP:0002521)	1.66813265
94	Myelomeningocele (HP:0002475)	1.65612513
95	Type II lissencephaly (HP:0007260)	1.63838514
96	Small hand (HP:0200055)	1.63356968
97	Absence seizures (HP:0002121)	1.62516553
98	Epileptiform EEG discharges (HP:0011182)	1.62199816
99	Esotropia (HP:0000565)	1.60926005
100	EEG with generalized epileptiform discharges (HP:0011198)	1.60576624

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.07410319
2	CASK	4.86350371
3	MAP3K4	3.04927482
4	TNIK	3.04252900
5	WNK3	2.88883784
6	MAP2K7	2.62673491
7	DYRK2	2.60673637
8	BCR	2.48232297
9	PNCK	2.34118551
10	NTRK2	2.19213675
11	MAPK13	2.12937023
12	EPHA4	2.05967963
13	NTRK3	1.91669292
14	DYRK3	1.87194289
15	MINK1	1.78478243
16	TRIM28	1.58079552
17	UHMK1	1.56965703
18	CSNK1G2	1.54345868
19	EPHB2	1.45164264
20	TYRO3	1.31626501
21	BMPR1B	1.31091795
22	MKNK2	1.30065589
23	CDK19	1.28094641
24	PRKCG	1.25323773
25	ERBB3	1.22720490
26	MAP4K2	1.21206066
27	MKNK1	1.19996386
28	MAP2K4	1.19806196
29	SIK2	1.18894535
30	CDC7	1.13240295
31	PINK1	1.10759309
32	CSNK1G1	1.08089274
33	CSNK1G3	1.07560610
34	DYRK1A	1.06173727
35	MAP3K9	1.06115099
36	PAK3	1.04533032
37	SGK223	1.03613602
38	SGK494	1.03613602
39	EPHA3	1.02793174
40	TAF1	0.98191037
41	DYRK1B	0.95379474
42	PLK2	0.92499315
43	CDK5	0.92015406
44	CSNK1A1L	0.90231038
45	SGK2	0.87184752
46	ADRBK2	0.87106111
47	FGFR2	0.85506437
48	ZAK	0.84581714
49	SRPK1	0.79655733
50	PLK3	0.78335095
51	NTRK1	0.76768884
52	PLK4	0.75767154
53	KSR1	0.74148826
54	TSSK6	0.72292922
55	LATS2	0.70866245
56	CDK14	0.69394434
57	CDK18	0.68576594
58	CAMK2A	0.66207158
59	WEE1	0.66181231
60	CDK15	0.64207378
61	PRKCE	0.64189122
62	CAMK1G	0.63280689
63	WNK4	0.62064882
64	CDK11A	0.60686425
65	CSNK1E	0.58389819
66	PHKG1	0.55533251
67	PHKG2	0.55533251
68	PKN1	0.54857974
69	MAP3K6	0.54071063
70	ACVR1B	0.53984759
71	GRK1	0.53754853
72	DAPK2	0.52863274
73	ERBB2	0.52424106
74	FGFR1	0.51555901
75	STK38L	0.51293747
76	RPS6KA4	0.51154656
77	INSRR	0.50867693
78	VRK1	0.50414064
79	NEK2	0.49254263
80	PRKCZ	0.46887832
81	STK11	0.44451042
82	CAMK2B	0.42668085
83	OXSR1	0.42638098
84	CDK3	0.42488536
85	PLK1	0.41113405
86	PRKG1	0.41036648
87	NUAK1	0.40333899
88	CSNK1D	0.38329197
89	FRK	0.38261124
90	PRKACA	0.38172674
91	BRAF	0.38081984
92	TGFBR1	0.37718006
93	PRKACB	0.35321484
94	CAMK4	0.35129237
95	CHEK2	0.33980887
96	PRKDC	0.33040298
97	MAPK15	0.32962970
98	CSNK1A1	0.32136774
99	SGK1	0.30295566
100	BRD4	0.30147862

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.16831917
2	GABAergic synapse_Homo sapiens_hsa04727	2.40774816
3	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.33655342
4	Morphine addiction_Homo sapiens_hsa05032	2.20664442
5	Phototransduction_Homo sapiens_hsa04744	2.15953323
6	Axon guidance_Homo sapiens_hsa04360	2.12025035
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.07641475
8	Parkinsons disease_Homo sapiens_hsa05012	2.04406331
9	Cocaine addiction_Homo sapiens_hsa05030	2.03259971
10	Dopaminergic synapse_Homo sapiens_hsa04728	2.03063058
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.03021025
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95287547
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.90952043
14	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.84665131
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.82031309
16	Circadian entrainment_Homo sapiens_hsa04713	1.81255455
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78982401
18	Protein export_Homo sapiens_hsa03060	1.73160743
19	Taste transduction_Homo sapiens_hsa04742	1.71043604
20	Basal cell carcinoma_Homo sapiens_hsa05217	1.64049530
21	Amphetamine addiction_Homo sapiens_hsa05031	1.55784648
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.53064138
23	Basal transcription factors_Homo sapiens_hsa03022	1.50530890
24	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.50476440
25	Huntingtons disease_Homo sapiens_hsa05016	1.44033631
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40453690
27	Serotonergic synapse_Homo sapiens_hsa04726	1.37989127
28	Cholinergic synapse_Homo sapiens_hsa04725	1.37789583
29	Alzheimers disease_Homo sapiens_hsa05010	1.36357161
30	Hippo signaling pathway_Homo sapiens_hsa04390	1.32577055
31	Insulin secretion_Homo sapiens_hsa04911	1.29034926
32	Long-term depression_Homo sapiens_hsa04730	1.22560602
33	Wnt signaling pathway_Homo sapiens_hsa04310	1.22232405
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21321475
35	Olfactory transduction_Homo sapiens_hsa04740	1.21125777
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18435309
37	Gap junction_Homo sapiens_hsa04540	1.17389452
38	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.16014603
39	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.12802854
40	Alcoholism_Homo sapiens_hsa05034	1.10018948
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01738110
42	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.98741111
43	Melanogenesis_Homo sapiens_hsa04916	0.98504873
44	Non-homologous end-joining_Homo sapiens_hsa03450	0.97056589
45	Oocyte meiosis_Homo sapiens_hsa04114	0.94624726
46	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.94594344
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85911029
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84252921
49	Long-term potentiation_Homo sapiens_hsa04720	0.79587126
50	RNA degradation_Homo sapiens_hsa03018	0.78692833
51	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.78048336
52	cAMP signaling pathway_Homo sapiens_hsa04024	0.76099262
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75954965
54	Butanoate metabolism_Homo sapiens_hsa00650	0.74542271
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.73042125
56	Ribosome_Homo sapiens_hsa03010	0.72466578
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72111002
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71597926
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71003132
60	Gastric acid secretion_Homo sapiens_hsa04971	0.69550105
61	Colorectal cancer_Homo sapiens_hsa05210	0.69129201
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65005746
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63687576
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.63516359
65	RNA polymerase_Homo sapiens_hsa03020	0.63495118
66	Ras signaling pathway_Homo sapiens_hsa04014	0.63316272
67	Cell cycle_Homo sapiens_hsa04110	0.62511416
68	RNA transport_Homo sapiens_hsa03013	0.62376036
69	Tight junction_Homo sapiens_hsa04530	0.62013821
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61934942
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59573683
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.59500531
73	Mismatch repair_Homo sapiens_hsa03430	0.58262376
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57704271
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57173536
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.53798942
77	Spliceosome_Homo sapiens_hsa03040	0.53571956
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53447988
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.51756056
80	Rap1 signaling pathway_Homo sapiens_hsa04015	0.51087631
81	Salivary secretion_Homo sapiens_hsa04970	0.49271412
82	Adherens junction_Homo sapiens_hsa04520	0.48671681
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47647721
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47274964
85	Propanoate metabolism_Homo sapiens_hsa00640	0.46844871
86	ErbB signaling pathway_Homo sapiens_hsa04012	0.45780107
87	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.44209520
88	Estrogen signaling pathway_Homo sapiens_hsa04915	0.43714024
89	Type II diabetes mellitus_Homo sapiens_hsa04930	0.41819718
90	Renin secretion_Homo sapiens_hsa04924	0.40757367
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38822728
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.38645789
93	Nitrogen metabolism_Homo sapiens_hsa00910	0.38371726
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.36691785
95	Regulation of autophagy_Homo sapiens_hsa04140	0.35748506
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.34506718
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33765907
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33507029
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.32304234
100	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.31432665

MSANTD3-TMEFF1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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