MSC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.70275113
2regulation of vitamin D biosynthetic process (GO:0060556)6.00728020
3negative regulation of macroautophagy (GO:0016242)5.54864964
4positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.45771906
5detection of molecule of bacterial origin (GO:0032490)5.34922237
6regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.16119575
7negative regulation of interleukin-12 production (GO:0032695)4.99358826
8regulation of vitamin metabolic process (GO:0030656)4.83657687
9regulation of T-helper 1 cell differentiation (GO:0045625)4.69690417
10response to peptidoglycan (GO:0032494)4.64186879
11regulation of cytokine secretion involved in immune response (GO:0002739)4.58145655
12positive regulation of chemokine biosynthetic process (GO:0045080)4.47481098
13regulation of mononuclear cell migration (GO:0071675)4.39472513
14lipopolysaccharide-mediated signaling pathway (GO:0031663)4.35418566
15regulation of chronic inflammatory response (GO:0002676)4.29509938
16T-helper 1 type immune response (GO:0042088)4.21373845
17regulation of podosome assembly (GO:0071801)4.20375361
18positive regulation of heat generation (GO:0031652)4.16436702
19regulation of gene silencing by RNA (GO:0060966)4.14054524
20regulation of posttranscriptional gene silencing (GO:0060147)4.14054524
21regulation of gene silencing by miRNA (GO:0060964)4.14054524
22myeloid dendritic cell differentiation (GO:0043011)4.11575181
23ribosome assembly (GO:0042255)4.07580928
24regulation of chemokine biosynthetic process (GO:0045073)3.97690514
25paraxial mesoderm development (GO:0048339)3.89884811
26cellular response to type I interferon (GO:0071357)3.88202935
27type I interferon signaling pathway (GO:0060337)3.88202935
28regulation of interferon-alpha production (GO:0032647)3.85691327
29response to type I interferon (GO:0034340)3.83078859
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.82658340
31immunoglobulin mediated immune response (GO:0016064)3.82048433
32macrophage activation involved in immune response (GO:0002281)3.79724966
33negative regulation of meiosis (GO:0045835)3.77665847
34post-embryonic morphogenesis (GO:0009886)3.75723173
35regulation of helicase activity (GO:0051095)3.66535111
36auditory receptor cell stereocilium organization (GO:0060088)3.65652971
37response to protozoan (GO:0001562)3.63447037
38interferon-gamma-mediated signaling pathway (GO:0060333)3.62891589
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.58956970
40defense response to protozoan (GO:0042832)3.52913006
41myeloid dendritic cell activation (GO:0001773)3.52804699
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48410227
43regulation of membrane protein ectodomain proteolysis (GO:0051043)3.48224190
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.45281412
45monocyte chemotaxis (GO:0002548)3.44250060
46positive regulation by symbiont of host defense response (GO:0052509)3.43896582
47modulation by symbiont of host defense response (GO:0052031)3.43896582
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43896582
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43896582
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.43896582
51modulation by symbiont of host immune response (GO:0052553)3.43896582
52negative regulation of cytokine production involved in immune response (GO:0002719)3.42374965
53detection of external biotic stimulus (GO:0098581)3.42356817
54trivalent inorganic anion homeostasis (GO:0072506)3.42153046
55phosphate ion homeostasis (GO:0055062)3.42153046
56germinal center formation (GO:0002467)3.41791461
57regulation of immunoglobulin secretion (GO:0051023)3.40656535
58negative regulation of androgen receptor signaling pathway (GO:0060766)3.37332060
59regulation of activation of Janus kinase activity (GO:0010533)3.33219048
60negative regulation of myeloid cell apoptotic process (GO:0033033)3.32708846
61positive regulation of NF-kappaB import into nucleus (GO:0042346)3.32315300
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.29913745
63glycosphingolipid catabolic process (GO:0046479)3.28890950
64interferon-gamma secretion (GO:0072643)3.28625236
65dendritic cell differentiation (GO:0097028)3.27928593
66regulation of interleukin-12 production (GO:0032655)3.24633592
67cellular response to lipopolysaccharide (GO:0071222)3.22987660
68positive regulation of gamma-delta T cell activation (GO:0046645)3.22872758
69positive regulation of interferon-alpha production (GO:0032727)3.22327723
70cellular response to thyroid hormone stimulus (GO:0097067)3.20558689
71adhesion of symbiont to host cell (GO:0044650)3.20339541
72virion attachment to host cell (GO:0019062)3.20339541
73CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.19871481
74positive regulation of type 2 immune response (GO:0002830)3.18249229
75activation of MAPKKK activity (GO:0000185)3.17966511
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17060169
77negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.16799885
78epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.14973699
79branching involved in labyrinthine layer morphogenesis (GO:0060670)3.14855523
80proteasome assembly (GO:0043248)3.13924979
81regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13369560
82regulation of heat generation (GO:0031650)3.12268996
83cellular response to molecule of bacterial origin (GO:0071219)3.11749338
84regulation of interferon-gamma biosynthetic process (GO:0045072)3.10634070
85positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.10463094
86bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08987636
87regulation of nuclear cell cycle DNA replication (GO:0033262)3.07963788
88regulation of interferon-beta biosynthetic process (GO:0045357)3.07738277
89purine nucleobase biosynthetic process (GO:0009113)3.07522909
90response to muramyl dipeptide (GO:0032495)3.06130130
91positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.05272677
92detection of biotic stimulus (GO:0009595)3.04942944
93cellular response to interferon-gamma (GO:0071346)3.03683264
94glycolipid catabolic process (GO:0019377)3.02630810
95positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.02518884
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01809460
97regulation of antigen processing and presentation (GO:0002577)3.01707795
98NIK/NF-kappaB signaling (GO:0038061)3.00912444
99positive regulation of antigen processing and presentation (GO:0002579)2.95526608
100regulation of T-helper cell differentiation (GO:0045622)2.94362174
101regulation of nitric oxide biosynthetic process (GO:0045428)2.93959751
102oligosaccharide catabolic process (GO:0009313)2.93723231
103T cell migration (GO:0072678)2.93155512
104nuclear pore organization (GO:0006999)2.92634836
105regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.89915730
106positive regulation of T-helper cell differentiation (GO:0045624)2.89021374
107positive regulation of fatty acid transport (GO:2000193)2.87502045
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87462901
109positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87168865
110positive regulation of interleukin-6 production (GO:0032755)2.86762686
111B cell mediated immunity (GO:0019724)2.85998281
112response to interferon-gamma (GO:0034341)2.85659262
113regulation of inflammatory response to antigenic stimulus (GO:0002861)2.85546863
114neutrophil activation involved in immune response (GO:0002283)2.85537036
115adhesion of symbiont to host (GO:0044406)2.83904115
116negative regulation of glial cell proliferation (GO:0060253)2.83427692
117negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.83183127
118regulation of interleukin-2 biosynthetic process (GO:0045076)2.81850354
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81537337
120tRNA methylation (GO:0030488)2.80864490
121negative regulation of response to nutrient levels (GO:0032108)2.79547478
122negative regulation of response to extracellular stimulus (GO:0032105)2.79547478
123positive regulation of interleukin-12 production (GO:0032735)2.77721039
124lung epithelium development (GO:0060428)2.77336805
125regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.76792586
126positive regulation of nitric oxide biosynthetic process (GO:0045429)2.76529166
127regulation of NF-kappaB import into nucleus (GO:0042345)2.75927629
128skeletal muscle tissue regeneration (GO:0043403)2.75382799
129negative regulation of lipid storage (GO:0010888)2.75308741
130regulation of SMAD protein import into nucleus (GO:0060390)2.74371979
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73526296
132negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.73241987
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73072233
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.72130488
135ventricular trabecula myocardium morphogenesis (GO:0003222)2.72021321
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71209253
137ribosome biogenesis (GO:0042254)2.71093634
138cellular response to biotic stimulus (GO:0071216)2.70830704
139mature B cell differentiation involved in immune response (GO:0002313)2.70698316
140negative regulation of production of molecular mediator of immune response (GO:0002701)2.70650488
141regulation of macrophage chemotaxis (GO:0010758)2.70522204
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70286783
143positive regulation of SMAD protein import into nucleus (GO:0060391)2.69709573
144oxygen transport (GO:0015671)2.69152239
145regulation of fever generation (GO:0031620)2.68512756
146nucleobase biosynthetic process (GO:0046112)2.67987025
147lung-associated mesenchyme development (GO:0060484)2.67090067
148pore complex assembly (GO:0046931)2.66365338
149histone arginine methylation (GO:0034969)2.65503303
150sulfate transport (GO:0008272)2.65167522
151rRNA modification (GO:0000154)2.60135308
152mesenchyme morphogenesis (GO:0072132)2.60039346
153regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.57997004
154sulfate transmembrane transport (GO:1902358)2.57458648
155lateral ventricle development (GO:0021670)2.57148088
156DNA catabolic process, exonucleolytic (GO:0000738)2.55990975
157signal transduction involved in cell cycle checkpoint (GO:0072395)2.54405983
158DNA replication checkpoint (GO:0000076)2.52318678
159single strand break repair (GO:0000012)2.51537293
160cellular anion homeostasis (GO:0030002)2.51253709
161signal transduction involved in DNA integrity checkpoint (GO:0072401)2.50834132
162signal transduction involved in DNA damage checkpoint (GO:0072422)2.50834132
163signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49054412
164signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49054412
165signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49054412
166ganglion development (GO:0061548)2.48180947
167regulation of hippo signaling (GO:0035330)2.47470296
168cell surface receptor signaling pathway involved in heart development (GO:0061311)2.46261027
169regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.45431422
170trabecula morphogenesis (GO:0061383)2.44147095
171DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43376147
172mitotic metaphase plate congression (GO:0007080)2.42270189
173intestinal epithelial cell development (GO:0060576)2.41490596
174regulation of G0 to G1 transition (GO:0070316)2.41140103
175sequestering of actin monomers (GO:0042989)2.39759838
176positive regulation of developmental pigmentation (GO:0048087)2.38810309
177negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.38535616
178intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.38100634
179signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.38100634
180positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.37096281
181positive regulation of protein homooligomerization (GO:0032464)2.37059186
182notochord development (GO:0030903)2.35326366
183neuron fate commitment (GO:0048663)2.33506206
184positive regulation of prostaglandin secretion (GO:0032308)2.31973851
185positive regulation of granulocyte chemotaxis (GO:0071624)2.30974532
186heart trabecula morphogenesis (GO:0061384)2.30946054
187negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.30760752
188negative regulation of ligase activity (GO:0051352)2.30760752
189regulation of double-strand break repair via homologous recombination (GO:0010569)2.30643124
190histone H4-K12 acetylation (GO:0043983)2.30158512
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.29975037
192somatic diversification of immune receptors via somatic mutation (GO:0002566)2.29975037
193regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.27259803
194doxorubicin metabolic process (GO:0044598)11.1373289
195daunorubicin metabolic process (GO:0044597)11.1373289
196polyketide metabolic process (GO:0030638)11.1373289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.67900500
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.22762784
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.22762784
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.22762784
5E2F7_22180533_ChIP-Seq_HELA_Human4.19142724
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.11840766
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse4.03884294
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.82117736
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63550816
10* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.63399582
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.58737812
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43308530
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse3.29715451
14* SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.27082683
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21857279
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.18427875
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18060217
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09781997
19MYC_18555785_ChIP-Seq_MESCs_Mouse3.03908332
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.01573594
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.96391750
22* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.95733369
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.95427270
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.85331745
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.77122378
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.76848824
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74279278
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69194316
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65722793
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61805935
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61486265
32* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.61054534
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.58321395
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.48628916
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46674787
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.44148539
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.42495081
38TP63_17297297_ChIP-ChIP_HaCaT_Human2.38763770
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31760520
40SOX2_18555785_ChIP-Seq_MESCs_Mouse2.28657585
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24394988
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15447827
43* VDR_21846776_ChIP-Seq_THP-1_Human2.13230580
44VDR_24763502_ChIP-Seq_THP-1_Human2.11161219
45NANOG_18692474_ChIP-Seq_MEFs_Mouse2.10154710
46BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08570454
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.07906870
48STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05073199
49MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03960121
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.01886125
51VDR_24787735_ChIP-Seq_THP-1_Human2.00488714
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.98551243
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96391339
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.95125312
55* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93060881
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92218947
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90655463
58NANOG_18692474_ChIP-Seq_MESCs_Mouse1.85118374
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.81942790
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.75504837
61SPI1_23547873_ChIP-Seq_NB4_Human1.74865079
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.70846924
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.70191320
64SPI1_23127762_ChIP-Seq_K562_Human1.67243304
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67168824
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66292257
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65294807
68MYC_22102868_ChIP-Seq_BL_Human1.64522993
69SOX2_18692474_ChIP-Seq_MEFs_Mouse1.64485705
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.63596537
71LXR_22292898_ChIP-Seq_THP-1_Human1.61432920
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61342393
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61200674
74MAF_26560356_Chip-Seq_TH1_Human1.60728764
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60471138
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60265910
77KAP1_27257070_Chip-Seq_ESCs_Mouse1.58628085
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.56842472
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56045601
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56016234
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55404353
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52503331
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52390279
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52114328
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50984088
86VDR_22108803_ChIP-Seq_LS180_Human1.49274307
87GATA1_22025678_ChIP-Seq_K562_Human1.47973269
88PU_27001747_Chip-Seq_BMDM_Mouse1.46757873
89SOX2_18692474_ChIP-Seq_MESCs_Mouse1.45910003
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.41051548
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39535372
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39213805
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.38565110
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37632699
95* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37167696
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35891148
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35832910
98EST1_17652178_ChIP-ChIP_JURKAT_Human1.35247233
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33127287
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32873040
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.32835010
102RUNX_20019798_ChIP-Seq_JUKART_Human1.29487475
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29141592
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.27925107
105* NANOG_16153702_ChIP-ChIP_HESCs_Human1.26885796
106EZH2_22144423_ChIP-Seq_EOC_Human1.26518866
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26417250
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26130797
109MYB_26560356_Chip-Seq_TH2_Human1.25734560
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25700075
111* NANOG_16518401_ChIP-PET_MESCs_Mouse1.25690642
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.25461148
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.23938327
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23264692
115TFEB_21752829_ChIP-Seq_HELA_Human1.22868227
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21757173
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21171692
118SCL_19346495_ChIP-Seq_HPC-7_Human1.21029165
119KDM2B_26808549_Chip-Seq_DND41_Human1.19833983
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19481988
121TCF7_22412390_ChIP-Seq_EML_Mouse1.18570097
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18402829
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.17639583
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16187812
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15711373
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15667846
127CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15328125
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14912014
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14196086
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14173714
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14007702
132TP53_20018659_ChIP-ChIP_R1E_Mouse1.13635480
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.12767315
134PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12538652
135UTX_26944678_Chip-Seq_JUKART_Human1.11956579
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11724039
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11128385
138GABP_17652178_ChIP-ChIP_JURKAT_Human1.09673417
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09647516
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09577828
141MAF_26560356_Chip-Seq_TH2_Human1.08858192
142* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08034354
143MYB_26560356_Chip-Seq_TH1_Human1.07632898
144GATA2_21666600_ChIP-Seq_HMVEC_Human1.05049420
145VDR_23849224_ChIP-Seq_CD4+_Human1.04660211
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03376774
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03204084
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.99543643
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97888716
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97814326
151* SOX2_16153702_ChIP-ChIP_HESCs_Human0.96616782
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.95111865
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95072404
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93768088
155GATA1_19941826_ChIP-Seq_K562_Human0.93399962
156GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92840631
157FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92747635
158STAT1_20625510_ChIP-Seq_HELA_Human0.92444510
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90527448
160CLOCK_20551151_ChIP-Seq_293T_Human0.90348149
161GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90237016
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89995052
163* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89842044
164PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88536001
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88234283
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87266539
167GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87076711
168UBF1/2_26484160_Chip-Seq_HMECs_Human0.86316351
169TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85566460
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85505004
171* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85474739
172STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.84651053
173SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84011855
174HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83949596
175RACK7_27058665_Chip-Seq_MCF-7_Human0.82600937
176ELF1_20517297_ChIP-Seq_JURKAT_Human0.82014559
177SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80504291
178EED_16625203_ChIP-ChIP_MESCs_Mouse0.79868563
179BCL6_27268052_Chip-Seq_Bcells_Human0.79359423
180CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78757421
181IRF8_21731497_ChIP-ChIP_J774_Mouse0.77600867
182HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77500729
183AR_21909140_ChIP-Seq_LNCAP_Human0.71944075
184XRN2_22483619_ChIP-Seq_HELA_Human0.71894004
185SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71579635
186TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71510576
187RXR_22108803_ChIP-Seq_LS180_Human0.70415472
188TTF2_22483619_ChIP-Seq_HELA_Human0.67997115
189MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.67825180
190RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67577533
191TBX3_20139965_ChIP-Seq_ESCs_Mouse0.66888246
192PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.66858163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.46403833
2MP0003303_peritoneal_inflammation5.21194037
3MP0005377_hearing/vestibular/ear_phenot4.00849228
4MP0003878_abnormal_ear_physiology4.00849228
5MP0008004_abnormal_stomach_pH3.64092449
6MP0005058_abnormal_lysosome_morphology3.34349107
7MP0002277_abnormal_respiratory_mucosa3.33022579
8MP0003436_decreased_susceptibility_to3.25842309
9MP0009785_altered_susceptibility_to3.25478975
10MP0003941_abnormal_skin_development3.20993032
11MP0009840_abnormal_foam_cell2.83000791
12MP0005000_abnormal_immune_tolerance2.76600838
13MP0003724_increased_susceptibility_to2.69206130
14MP0001346_abnormal_lacrimal_gland2.67182109
15MP0005645_abnormal_hypothalamus_physiol2.65848668
16MP0002139_abnormal_hepatobiliary_system2.64834794
17MP0003300_gastrointestinal_ulcer2.62764382
18MP0002419_abnormal_innate_immunity2.40271666
19MP0005025_abnormal_response_to2.33748406
20MP0003136_yellow_coat_color2.31807326
21MP0003879_abnormal_hair_cell2.30495389
22MP0000343_altered_response_to2.28713575
23MP0009764_decreased_sensitivity_to2.27745280
24MP0008057_abnormal_DNA_replication2.18426099
25MP0002452_abnormal_antigen_presenting2.14751350
26MP0003075_altered_response_to2.13358288
27MP0002876_abnormal_thyroid_physiology2.12231205
28MP0003693_abnormal_embryo_hatching2.11229276
29MP0001800_abnormal_humoral_immune2.09344272
30MP0002723_abnormal_immune_serum2.08634962
31MP0005451_abnormal_body_composition2.06652099
32MP0003111_abnormal_nucleus_morphology2.06079324
33MP0001348_abnormal_lacrimal_gland2.05205602
34MP0010030_abnormal_orbit_morphology2.01620717
35MP0001533_abnormal_skeleton_physiology1.98012300
36MP0001853_heart_inflammation1.90835427
37MP0005503_abnormal_tendon_morphology1.89242008
38MP0006054_spinal_hemorrhage1.87660784
39MP0000685_abnormal_immune_system1.86713506
40MP0004947_skin_inflammation1.85732082
41MP0009278_abnormal_bone_marrow1.83680033
42MP0003172_abnormal_lysosome_physiology1.83665761
43MP0005171_absent_coat_pigmentation1.83258175
44MP0002163_abnormal_gland_morphology1.82831547
45MP0001485_abnormal_pinna_reflex1.81210191
46MP0005167_abnormal_blood-brain_barrier1.80334741
47MP0000678_abnormal_parathyroid_gland1.76131837
48MP0000604_amyloidosis1.72826696
49MP0001845_abnormal_inflammatory_respons1.72651614
50MP0002998_abnormal_bone_remodeling1.72523266
51MP0001986_abnormal_taste_sensitivity1.70342344
52MP0008438_abnormal_cutaneous_collagen1.69641429
53MP0001819_abnormal_immune_cell1.69147157
54MP0002420_abnormal_adaptive_immunity1.69014050
55MP0000516_abnormal_urinary_system1.67305527
56MP0005367_renal/urinary_system_phenotyp1.67305527
57MP0004133_heterotaxia1.66905364
58MP0004957_abnormal_blastocyst_morpholog1.63076890
59MP0003806_abnormal_nucleotide_metabolis1.62017787
60MP0010155_abnormal_intestine_physiology1.58801563
61MP0000566_synostosis1.58065089
62MP0003077_abnormal_cell_cycle1.57934704
63MP0006292_abnormal_olfactory_placode1.56926298
64MP0008469_abnormal_protein_level1.55107539
65MP0004510_myositis1.52794767
66MP0002405_respiratory_system_inflammati1.52359284
67MP0008007_abnormal_cellular_replicative1.51526722
68MP0003646_muscle_fatigue1.51395229
69MP0009333_abnormal_splenocyte_physiolog1.48732683
70MP0005397_hematopoietic_system_phenotyp1.44785902
71MP0001545_abnormal_hematopoietic_system1.44785902
72MP0009697_abnormal_copulation1.41685944
73MP0005310_abnormal_salivary_gland1.36122817
74MP0002332_abnormal_exercise_endurance1.33949404
75MP0001542_abnormal_bone_strength1.32948898
76MP0005166_decreased_susceptibility_to1.32133407
77MP0005275_abnormal_skin_tensile1.29910907
78MP0004782_abnormal_surfactant_physiolog1.29074103
79MP0000613_abnormal_salivary_gland1.28045987
80MP0008932_abnormal_embryonic_tissue1.27442898
81MP0005257_abnormal_intraocular_pressure1.25976911
82MP0003191_abnormal_cellular_cholesterol1.25786473
83MP0003786_premature_aging1.25258712
84MP0000750_abnormal_muscle_regeneration1.24191546
85MP0010094_abnormal_chromosome_stability1.23984610
86MP0000762_abnormal_tongue_morphology1.22466618
87MP0000716_abnormal_immune_system1.22270877
88MP0003718_maternal_effect1.22050886
89MP0008058_abnormal_DNA_repair1.21849903
90MP0003091_abnormal_cell_migration1.20436619
91MP0002877_abnormal_melanocyte_morpholog1.19649325
92MP0000049_abnormal_middle_ear1.18058173
93MP0000470_abnormal_stomach_morphology1.16652272
94MP0005464_abnormal_platelet_physiology1.15543819
95MP0002938_white_spotting1.15195290
96MP0003690_abnormal_glial_cell1.09056038
97MP0001293_anophthalmia1.07238836
98MP0002249_abnormal_larynx_morphology1.03991705
99MP0003656_abnormal_erythrocyte_physiolo1.03990646
100MP0002398_abnormal_bone_marrow1.02634406
101MP0002735_abnormal_chemical_nociception1.00987485
102* MP0000733_abnormal_muscle_development1.00105141
103MP0003195_calcinosis0.99881765
104MP0000371_diluted_coat_color0.99245748
105MP0005508_abnormal_skeleton_morphology0.98477013
106MP0005164_abnormal_response_to0.98336812
107MP0003279_aneurysm0.98115377
108MP0006276_abnormal_autonomic_nervous0.97720556
109MP0005390_skeleton_phenotype0.95309003
110MP0000858_altered_metastatic_potential0.94826448
111MP0009763_increased_sensitivity_to0.94793228
112MP0005165_increased_susceptibility_to0.94261872
113MP0002429_abnormal_blood_cell0.93680244
114MP0006082_CNS_inflammation0.92448871
115MP0001835_abnormal_antigen_presentation0.91900924
116MP0003566_abnormal_cell_adhesion0.90748098
117MP0004858_abnormal_nervous_system0.89860717
118MP0002148_abnormal_hypersensitivity_rea0.86572914
119MP0005023_abnormal_wound_healing0.85652482
120MP0000920_abnormal_myelination0.85628621
121MP0002933_joint_inflammation0.85296865
122MP0000689_abnormal_spleen_morphology0.85200505
123MP0000627_abnormal_mammary_gland0.84865800
124MP0004272_abnormal_basement_membrane0.83839328
125MP0010352_gastrointestinal_tract_polyps0.82355458
126MP0000350_abnormal_cell_proliferation0.81771502
127MP0003763_abnormal_thymus_physiology0.81057629
128MP0001873_stomach_inflammation0.80938763
129MP0003936_abnormal_reproductive_system0.80297871
130MP0003448_altered_tumor_morphology0.80192755
131MP0005623_abnormal_meninges_morphology0.79928064
132MP0002751_abnormal_autonomic_nervous0.79494629
133MP0002160_abnormal_reproductive_system0.77898289
134MP0005076_abnormal_cell_differentiation0.77669255
135MP0002108_abnormal_muscle_morphology0.77351808
136MP0002722_abnormal_immune_system0.77024344
137MP0008874_decreased_physiological_sensi0.76394483
138* MP0003755_abnormal_palate_morphology0.75854079
139MP0003795_abnormal_bone_structure0.75666750
140MP0009765_abnormal_xenobiotic_induced0.74916522
141MP0002233_abnormal_nose_morphology0.74903946
142MP0005647_abnormal_sex_gland0.74640211
143MP0001663_abnormal_digestive_system0.74334207
144MP0003938_abnormal_ear_development0.73574769
145MP0002127_abnormal_cardiovascular_syste0.73476796
146MP0003453_abnormal_keratinocyte_physiol0.73106344
147MP0003329_amyloid_beta_deposits0.72326124
148MP0005389_reproductive_system_phenotype0.71110460
149MP0005423_abnormal_somatic_nervous0.70527165
150MP0000534_abnormal_ureter_morphology0.70368006
151MP0008260_abnormal_autophagy0.67203768
152MP0003705_abnormal_hypodermis_morpholog0.67090148
153MP0002111_abnormal_tail_morphology0.66438969
154MP0004883_abnormal_blood_vessel0.65921096
155MP0005595_abnormal_vascular_smooth0.65838403
156MP0010307_abnormal_tumor_latency0.65769470
157MP0000249_abnormal_blood_vessel0.65359747
158MP0009250_abnormal_appendicular_skeleto0.64703817
159MP0003183_abnormal_peptide_metabolism0.63861181
160MP0004808_abnormal_hematopoietic_stem0.63665350
161MP0002085_abnormal_embryonic_tissue0.63427084
162MP0000428_abnormal_craniofacial_morphol0.63044787
163MP0002837_dystrophic_cardiac_calcinosis0.62383291
164MP0001286_abnormal_eye_development0.60745067
165MP0003828_pulmonary_edema0.60483659
166MP0000432_abnormal_head_morphology0.60353123
167MP0001119_abnormal_female_reproductive0.60187074
168MP0001790_abnormal_immune_system0.58894404
169MP0005387_immune_system_phenotype0.58894404
170MP0008789_abnormal_olfactory_epithelium0.58410209
171MP0003937_abnormal_limbs/digits/tail_de0.56910836
172MP0002138_abnormal_hepatobiliary_system0.56219220
173MP0003950_abnormal_plasma_membrane0.55831211
174MP0003119_abnormal_digestive_system0.55283189
175MP0001849_ear_inflammation0.54788869
176MP0005671_abnormal_response_to0.53616110
177MP0002116_abnormal_craniofacial_bone0.51852430
178MP0004084_abnormal_cardiac_muscle0.51487361

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.03373109
2Abnormality of liposaccharide metabolism (HP:0010968)7.03373109
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.03373109
4Alopecia of scalp (HP:0002293)6.27283973
5Unilateral renal agenesis (HP:0000122)5.62021361
6Type 2 muscle fiber atrophy (HP:0003554)5.28667003
7Systemic lupus erythematosus (HP:0002725)4.71714997
8Muscle fiber atrophy (HP:0100295)4.69287203
9Vacuolated lymphocytes (HP:0001922)4.62403296
10Abnormality of macrophages (HP:0004311)4.55020511
11Parakeratosis (HP:0001036)4.43932397
12Dysostosis multiplex (HP:0000943)4.42184233
13Follicular hyperkeratosis (HP:0007502)4.30325205
14Loss of speech (HP:0002371)4.26424617
15Increased cerebral lipofuscin (HP:0011813)4.26328511
16Disinhibition (HP:0000734)4.10766035
17Orchitis (HP:0100796)3.94830401
18Retrobulbar optic neuritis (HP:0100654)3.94319471
19Optic neuritis (HP:0100653)3.94319471
20Recurrent bacterial skin infections (HP:0005406)3.92120401
21Duplicated collecting system (HP:0000081)3.87547888
22Abnormality of the renal collecting system (HP:0004742)3.74873669
23Mediastinal lymphadenopathy (HP:0100721)3.70254383
24Nuclear cataract (HP:0100018)3.67561882
25Bilateral sensorineural hearing impairment (HP:0008619)3.64314452
26Autoimmune thrombocytopenia (HP:0001973)3.61119061
27Mutism (HP:0002300)3.59078851
28Recurrent abscess formation (HP:0002722)3.55358271
29Eczematoid dermatitis (HP:0000976)3.53048577
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.43367517
31Myositis (HP:0100614)3.37354500
32Absent eyelashes (HP:0000561)3.36258753
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32250392
34Cheilitis (HP:0100825)3.31425400
35Septo-optic dysplasia (HP:0100842)3.25647335
36Breast hypoplasia (HP:0003187)3.22556543
37Abnormality of polysaccharide metabolism (HP:0011012)3.22362445
38Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22362445
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22362445
40Abnormality of dental color (HP:0011073)3.21820863
41Fatigable weakness (HP:0003473)3.21469877
42Abnormality of the neuromuscular junction (HP:0003398)3.21469877
43Stomatitis (HP:0010280)3.19492122
44Neurofibrillary tangles (HP:0002185)3.14444994
45Birth length less than 3rd percentile (HP:0003561)3.12754855
46Recurrent corneal erosions (HP:0000495)3.11995455
47Gastrointestinal stroma tumor (HP:0100723)3.10325335
48Mucopolysacchariduria (HP:0008155)3.03485026
49Urinary glycosaminoglycan excretion (HP:0003541)3.03485026
50Glomerulonephritis (HP:0000099)2.99744421
51Absent eyebrow (HP:0002223)2.98733957
52Chromsome breakage (HP:0040012)2.96512483
53Axonal loss (HP:0003447)2.91810015
54Pulmonary infiltrates (HP:0002113)2.87583095
55Ureteral duplication (HP:0000073)2.86517150
56Muscle fiber splitting (HP:0003555)2.85965886
57Vasculitis (HP:0002633)2.84740781
58Increased serum ferritin (HP:0003281)2.82472827
59Increased IgM level (HP:0003496)2.81355252
60Absent radius (HP:0003974)2.80152796
61Recurrent gram-negative bacterial infections (HP:0005420)2.78470940
62Apathy (HP:0000741)2.75935170
63Sparse eyelashes (HP:0000653)2.75436838
64Hyperphosphatemia (HP:0002905)2.69069514
65Keratoconjunctivitis sicca (HP:0001097)2.68687532
66Hydroxyprolinuria (HP:0003080)2.68487093
67Abnormality of proline metabolism (HP:0010907)2.68487093
68Diminished motivation (HP:0000745)2.66391488
69Abnormal trabecular bone morphology (HP:0100671)2.65107050
70Absent forearm bone (HP:0003953)2.62852199
71Aplasia involving forearm bones (HP:0009822)2.62852199
72Asplenia (HP:0001746)2.61111459
73Myocardial infarction (HP:0001658)2.61064416
74Hematochezia (HP:0002573)2.58907768
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57481299
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.55749486
77IgA deficiency (HP:0002720)2.53445448
78Weak cry (HP:0001612)2.53214876
79Metaphyseal irregularity (HP:0003025)2.50122900
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49809465
81Recurrent viral infections (HP:0004429)2.48527990
82Wrist flexion contracture (HP:0001239)2.46618908
83Purpura (HP:0000979)2.45786996
84Progressive neurologic deterioration (HP:0002344)2.45147210
85Cerebral inclusion bodies (HP:0100314)2.44105230
86Keratitis (HP:0000491)2.39991916
87Rough bone trabeculation (HP:0100670)2.39469042
88Aplasia of the musculature (HP:0100854)2.36644940
89Chronic mucocutaneous candidiasis (HP:0002728)2.34927883
90Recurrent cutaneous fungal infections (HP:0011370)2.34927883
91Conical tooth (HP:0000698)2.34008438
92Emphysema (HP:0002097)2.33658253
93Petechiae (HP:0000967)2.32904453
94Ectopic kidney (HP:0000086)2.32885302
95Absent/shortened dynein arms (HP:0200106)2.30677391
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.30677391
97Complement deficiency (HP:0004431)2.30668520
98Gangrene (HP:0100758)2.30221340
99Hemoptysis (HP:0002105)2.30191863
100Patellar aplasia (HP:0006443)2.28268567
101Neuronal loss in central nervous system (HP:0002529)2.26728987
102Vertebral compression fractures (HP:0002953)2.25884219
103Abnormality of placental membranes (HP:0011409)2.24827068
104Amniotic constriction ring (HP:0009775)2.24827068
105Interstitial pulmonary disease (HP:0006530)2.24602989
106Absent hand (HP:0004050)2.24119719
107Difficulty climbing stairs (HP:0003551)2.23871092
108Restrictive lung disease (HP:0002091)2.21459219
109Obstructive lung disease (HP:0006536)2.21406623
110Chronic obstructive pulmonary disease (HP:0006510)2.21406623
111Meningitis (HP:0001287)2.21284960
112Palmar hyperkeratosis (HP:0010765)2.21107250
113Basal ganglia calcification (HP:0002135)2.20732982
114Keratoconjunctivitis (HP:0001096)2.20417932
115Asymmetric septal hypertrophy (HP:0001670)2.18893019
116Upper motor neuron abnormality (HP:0002127)2.18308666
117Right ventricular cardiomyopathy (HP:0011663)2.17710104
118Breast aplasia (HP:0100783)2.17603517
119Nausea (HP:0002018)2.17388549
120Hepatosplenomegaly (HP:0001433)2.16860674
121Inappropriate behavior (HP:0000719)2.16137568
122Polyneuropathy (HP:0001271)2.15897620
123Cerebral hypomyelination (HP:0006808)2.15701869
124Ankle contracture (HP:0006466)2.15026157
125Aplasia/Hypoplasia of the patella (HP:0006498)2.14124247
126Recurrent skin infections (HP:0001581)2.14010588
127Upper limb muscle weakness (HP:0003484)2.13508710
128Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12788973
129Palmoplantar hyperkeratosis (HP:0000972)2.12526174
130Thin bony cortex (HP:0002753)2.12272898
131Easy fatigability (HP:0003388)2.11323070
132Abnormality of iron homeostasis (HP:0011031)2.11123253
133Spondylolisthesis (HP:0003302)2.10415538
134Hypergammaglobulinemia (HP:0010702)2.10050820
135Aplasia/Hypoplasia of the breasts (HP:0010311)2.08482437
136Amyloidosis (HP:0011034)2.08319657
137Distal lower limb amyotrophy (HP:0008944)2.07399086
138Rhabdomyosarcoma (HP:0002859)2.06135930
139Prostate neoplasm (HP:0100787)2.03603172
140Aplasia/Hypoplasia involving the musculature (HP:0001460)2.03219326
141Personality changes (HP:0000751)2.03139939
142Agnosia (HP:0010524)2.02794509
143Prolonged neonatal jaundice (HP:0006579)2.01900514
144Hypohidrosis (HP:0000966)2.01845884
145Arthralgia (HP:0002829)2.01337261
146Blepharitis (HP:0000498)2.01260828
147Aplasia/Hypoplasia of the uvula (HP:0010293)2.01163792
148Plantar hyperkeratosis (HP:0007556)2.00380115
149Recurrent fungal infections (HP:0002841)2.00159006
150Autoimmune hemolytic anemia (HP:0001890)1.99827448
151Premature rupture of membranes (HP:0001788)1.99689633
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99365517
153Abnormality of complement system (HP:0005339)1.98989893
154Elevated erythrocyte sedimentation rate (HP:0003565)1.94876004
155Hypertensive crisis (HP:0100735)1.93612042
156Dementia (HP:0000726)1.92121782
157Neoplasm of the respiratory system (HP:0100606)1.90948791
158Erythroderma (HP:0001019)1.90286999
159Increased connective tissue (HP:0009025)1.90045758
160Nail dystrophy (HP:0008404)1.89078794
161Distal lower limb muscle weakness (HP:0009053)1.89060313
162Urticaria (HP:0001025)1.88910446
163Abnormality of the nasal mucosa (HP:0000433)1.87988117
164Abnormality of the pleura (HP:0002103)1.87840466
165Maternal diabetes (HP:0009800)1.86134351
166Ectropion (HP:0000656)1.85722591
167Malnutrition (HP:0004395)1.85175657
168Arterial thrombosis (HP:0004420)1.85153027
169Lymphopenia (HP:0001888)1.85142029
170Bone pain (HP:0002653)1.84535017
171T lymphocytopenia (HP:0005403)1.84224841
172Acrocyanosis (HP:0001063)1.84169932
173Popliteal pterygium (HP:0009756)1.83646512
174Pelvic girdle muscle weakness (HP:0003749)1.83645809
175Memory impairment (HP:0002354)1.83396129
176Cellulitis (HP:0100658)1.82519219
177Absent septum pellucidum (HP:0001331)1.82453973
178Increased IgE level (HP:0003212)1.81771527
179Malignant hyperthermia (HP:0002047)1.81713232
180Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81108313
181Adrenal hypoplasia (HP:0000835)1.80940406
182Selective tooth agenesis (HP:0001592)1.79453879
183Amaurosis fugax (HP:0100576)1.77103516
184Tongue fasciculations (HP:0001308)1.76669177
185Abnormality of the septum pellucidum (HP:0007375)1.76199305
186Hypoparathyroidism (HP:0000829)1.75893178
187Meckel diverticulum (HP:0002245)1.75882930
188Chronic otitis media (HP:0000389)1.75445072
189Trismus (HP:0000211)1.74396377
190Ependymoma (HP:0002888)1.73132022
191Shoulder girdle muscle weakness (HP:0003547)1.72578501
192Hypergonadotropic hypogonadism (HP:0000815)1.72173519
193Congenital, generalized hypertrichosis (HP:0004540)1.71800131
194Abnormality of the labia minora (HP:0012880)1.71012030
195Neoplasm of the lung (HP:0100526)1.69991113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.91666436
2SIK35.82130316
3BUB14.81832902
4TSSK63.16350537
5TBK12.85977595
6MATK2.77347334
7AKT32.69977026
8ZAK2.61627727
9MAP3K142.52006351
10WEE12.51854419
11RIPK42.49174099
12FGFR42.31853545
13SIK22.16503074
14STK38L2.14167649
15MAP4K12.09956237
16BLK2.07251493
17TYK22.04091346
18FGR2.03305090
19PRPF4B2.00121410
20IKBKE1.93317052
21TGFBR21.81489866
22ERN11.81168598
23SIK11.80103534
24PAK41.78241799
25MAP3K31.71726219
26EPHA31.67142419
27CSK1.66789236
28MARK31.64576560
29TAOK11.63268247
30RIPK11.57322890
31CDK81.53859032
32SRPK11.40600038
33DYRK31.33232198
34TAOK21.29334306
35BMPR1B1.27322297
36ERBB31.27138270
37MAP3K131.26508758
38EIF2AK11.26244038
39MUSK1.23812664
40CDK121.21926369
41ABL21.21734245
42JAK11.19126465
43STK161.17212821
44PLK31.15873125
45IRAK31.13169864
46PDGFRA1.12485664
47MAP2K31.11792358
48EIF2AK21.11313682
49NEK91.10089153
50NME11.09023823
51TTK1.08468356
52TYRO31.07459626
53BMPR21.06486736
54BCR1.05304977
55ACVR1B1.04501396
56PIM21.02272604
57DYRK21.01782065
58VRK10.99767481
59IRAK10.98101296
60CSF1R0.96515970
61RPS6KB20.96182948
62SYK0.95480977
63LYN0.94190731
64LATS10.92634406
65CHUK0.88549050
66GRK50.87560356
67PLK10.87532755
68MAP3K50.87063366
69PLK40.86009530
70MOS0.83947565
71MARK10.83525959
72MAP3K10.83273704
73PNCK0.83072128
74KIT0.82483926
75CDK70.81030785
76IRAK40.80029081
77MKNK20.79222629
78TESK10.79213792
79MST40.78939663
80IKBKB0.78871631
81ZAP700.77296594
82NEK20.76478601
83BRAF0.76048998
84CLK10.74492956
85NLK0.72571030
86FER0.71315305
87STK100.70741951
88DDR20.69498090
89MELK0.67955793
90CHEK20.65608046
91DAPK30.64285819
92MKNK10.63719981
93TGFBR10.63579624
94BRSK20.63189336
95OBSCN0.63188153
96JAK20.62219888
97LATS20.62067127
98TLK10.58311652
99PIM10.58199319
100YES10.57531237
101MAPK40.57322334
102ATR0.56266676
103ALK0.56087162
104LCK0.54599988
105STK240.52072393
106ADRBK20.51411392
107FGFR30.50794806
108MAPKAPK30.50360811
109MAP3K110.49372382
110PINK10.47748728
111CDK60.47217912
112NEK10.45496003
113PDK20.44693882
114NME20.44493389
115RPS6KA50.44135278
116CHEK10.44078354
117PKN10.41312748
118BTK0.40337687
119MAPK70.40096708
120TESK20.39417158
121RPS6KC10.39374142
122RPS6KL10.39374142
123GRK70.39169520
124HCK0.38926217
125AKT20.38315848
126LIMK10.38050976
127ARAF0.36524413
128TXK0.36093593
129TTN0.34954567
130ICK0.34681632
131PLK20.34517975
132INSR0.33341977
133AURKB0.32829166
134CSNK2A10.32763653
135CDC42BPA0.32205984
136MAP2K60.31520134
137ABL10.31265145
138MAP3K80.31226286
139TRIB30.31109854
140PRKCD0.29701445
141AURKA0.29478990
142CDK40.29152469
143PDGFRB0.28933944
144EPHB10.28376539
145CDK150.28183748
146HIPK20.27839302
147MAPK130.27515430
148RPS6KA60.27371821
149DAPK20.26634220
150PRKCI0.26494029
151PAK10.26385525
152BMX0.26371436
153EIF2AK30.25797059
154JAK30.25745918
155CDK11A0.25536751
156PRKCE0.25516449
157CSNK1D0.25105404
158MAP2K20.25009297
159RPS6KA20.24968858
160IRAK20.24576230
161CDK180.24420950
162BRSK10.24389739
163CDK140.24351989
164SMG10.23846256
165MAPKAPK20.23611849
166GSK3A0.22371958
167MAPK110.21553865

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.01297204
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37965794
3Other glycan degradation_Homo sapiens_hsa005112.69049505
4DNA replication_Homo sapiens_hsa030302.56396776
5Osteoclast differentiation_Homo sapiens_hsa043802.54619211
6RNA polymerase_Homo sapiens_hsa030202.54122628
7Staphylococcus aureus infection_Homo sapiens_hsa051502.43229833
8Malaria_Homo sapiens_hsa051442.35350880
9Lysosome_Homo sapiens_hsa041422.33309243
10Homologous recombination_Homo sapiens_hsa034402.24648872
11RNA transport_Homo sapiens_hsa030132.21976641
12Mismatch repair_Homo sapiens_hsa034302.21001703
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07091959
14Spliceosome_Homo sapiens_hsa030402.03488854
15Fanconi anemia pathway_Homo sapiens_hsa034601.95370101
16Cell cycle_Homo sapiens_hsa041101.86861452
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81837855
18Allograft rejection_Homo sapiens_hsa053301.79267222
19Vitamin B6 metabolism_Homo sapiens_hsa007501.65935595
20Base excision repair_Homo sapiens_hsa034101.62403129
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.61078165
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.60283254
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60059039
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.59675706
25Hippo signaling pathway_Homo sapiens_hsa043901.59016775
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58842257
27Antigen processing and presentation_Homo sapiens_hsa046121.51220243
28Notch signaling pathway_Homo sapiens_hsa043301.49805281
29p53 signaling pathway_Homo sapiens_hsa041151.45412203
30Epstein-Barr virus infection_Homo sapiens_hsa051691.43095483
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.40855742
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40108055
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38708243
34Hematopoietic cell lineage_Homo sapiens_hsa046401.37378803
35B cell receptor signaling pathway_Homo sapiens_hsa046621.36861940
36Pyrimidine metabolism_Homo sapiens_hsa002401.34729765
37Primary immunodeficiency_Homo sapiens_hsa053401.34136056
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33919609
39Autoimmune thyroid disease_Homo sapiens_hsa053201.30193285
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29376497
41One carbon pool by folate_Homo sapiens_hsa006701.27315967
42Regulation of autophagy_Homo sapiens_hsa041401.26789338
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26600163
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23202611
45African trypanosomiasis_Homo sapiens_hsa051431.19283315
46Legionellosis_Homo sapiens_hsa051341.15922016
47HTLV-I infection_Homo sapiens_hsa051661.10792874
48Hepatitis C_Homo sapiens_hsa051601.10678716
49Hepatitis B_Homo sapiens_hsa051611.10375918
50Asthma_Homo sapiens_hsa053101.09402786
51Chemokine signaling pathway_Homo sapiens_hsa040621.07892638
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06940045
53Basal transcription factors_Homo sapiens_hsa030221.06753820
54Nucleotide excision repair_Homo sapiens_hsa034201.06277467
55Hedgehog signaling pathway_Homo sapiens_hsa043401.05728125
56Graft-versus-host disease_Homo sapiens_hsa053321.04377460
57Basal cell carcinoma_Homo sapiens_hsa052171.04223100
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02784947
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95805606
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95025536
61TGF-beta signaling pathway_Homo sapiens_hsa043500.94664411
62Ribosome_Homo sapiens_hsa030100.93976692
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93754758
64Apoptosis_Homo sapiens_hsa042100.92990656
65Arachidonic acid metabolism_Homo sapiens_hsa005900.92461578
66MicroRNAs in cancer_Homo sapiens_hsa052060.89882199
67Viral myocarditis_Homo sapiens_hsa054160.88184454
68Amoebiasis_Homo sapiens_hsa051460.88147400
69Rheumatoid arthritis_Homo sapiens_hsa053230.87712383
70Measles_Homo sapiens_hsa051620.85763771
71Herpes simplex infection_Homo sapiens_hsa051680.85660341
72Purine metabolism_Homo sapiens_hsa002300.83767279
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81993877
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80731716
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79421161
76Type I diabetes mellitus_Homo sapiens_hsa049400.77051539
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75450128
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75116813
79T cell receptor signaling pathway_Homo sapiens_hsa046600.75031562
80Adherens junction_Homo sapiens_hsa045200.74228354
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.74192216
82Leishmaniasis_Homo sapiens_hsa051400.74172528
83Melanoma_Homo sapiens_hsa052180.73269777
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71495028
85Small cell lung cancer_Homo sapiens_hsa052220.71365465
86Toxoplasmosis_Homo sapiens_hsa051450.70944264
87Sphingolipid metabolism_Homo sapiens_hsa006000.70821959
88Mineral absorption_Homo sapiens_hsa049780.70734462
89ECM-receptor interaction_Homo sapiens_hsa045120.70358049
90Acute myeloid leukemia_Homo sapiens_hsa052210.69410909
91Systemic lupus erythematosus_Homo sapiens_hsa053220.69336629
92Influenza A_Homo sapiens_hsa051640.68051773
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67709759
94Pathways in cancer_Homo sapiens_hsa052000.67466780
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66111188
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65979473
97Collecting duct acid secretion_Homo sapiens_hsa049660.64280099
98TNF signaling pathway_Homo sapiens_hsa046680.63747848
99Prolactin signaling pathway_Homo sapiens_hsa049170.61636097
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60079362
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.59305962
102Arginine and proline metabolism_Homo sapiens_hsa003300.59244523
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58411814
104Viral carcinogenesis_Homo sapiens_hsa052030.58335734
105Prion diseases_Homo sapiens_hsa050200.57912596
106RNA degradation_Homo sapiens_hsa030180.56980421
107Complement and coagulation cascades_Homo sapiens_hsa046100.56839038
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54498894
109Tuberculosis_Homo sapiens_hsa051520.54453173
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53465440
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.53230776
112VEGF signaling pathway_Homo sapiens_hsa043700.52188494
113FoxO signaling pathway_Homo sapiens_hsa040680.51841099
114Wnt signaling pathway_Homo sapiens_hsa043100.51025233
115Vibrio cholerae infection_Homo sapiens_hsa051100.51003890
116Tight junction_Homo sapiens_hsa045300.50694553
117Sulfur metabolism_Homo sapiens_hsa009200.50631016
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49750487
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.48962628
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48600465
121Galactose metabolism_Homo sapiens_hsa000520.46309524
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.46067330
123mRNA surveillance pathway_Homo sapiens_hsa030150.46060641
124Shigellosis_Homo sapiens_hsa051310.45894458
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44983980
126Bladder cancer_Homo sapiens_hsa052190.43523423
127Circadian rhythm_Homo sapiens_hsa047100.43011159
128Pertussis_Homo sapiens_hsa051330.42414671
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40834401
130Fructose and mannose metabolism_Homo sapiens_hsa000510.40387524
131Salmonella infection_Homo sapiens_hsa051320.39242973
132Dorso-ventral axis formation_Homo sapiens_hsa043200.38930878
133Type II diabetes mellitus_Homo sapiens_hsa049300.36513955
134Phagosome_Homo sapiens_hsa041450.36498728
135MAPK signaling pathway_Homo sapiens_hsa040100.34566896
136Axon guidance_Homo sapiens_hsa043600.34353591
137HIF-1 signaling pathway_Homo sapiens_hsa040660.32539131
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29115625
139Chronic myeloid leukemia_Homo sapiens_hsa052200.28788567
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.28503189
141Pancreatic cancer_Homo sapiens_hsa052120.27073643
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26512070
143Endocytosis_Homo sapiens_hsa041440.21171703
144PPAR signaling pathway_Homo sapiens_hsa033200.20176197
145Proteoglycans in cancer_Homo sapiens_hsa052050.19309768
146Renin-angiotensin system_Homo sapiens_hsa046140.17729575
147Insulin resistance_Homo sapiens_hsa049310.15270928
148Renal cell carcinoma_Homo sapiens_hsa052110.14285820
149Tryptophan metabolism_Homo sapiens_hsa003800.13905216
150Pentose phosphate pathway_Homo sapiens_hsa000300.11922485
151Glutathione metabolism_Homo sapiens_hsa004800.10485839
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09834630

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