Rank | Gene Set | Z-score |
---|---|---|
1 | DNA unwinding involved in DNA replication (GO:0006268) | 5.77049689 |
2 | DNA replication initiation (GO:0006270) | 5.02560371 |
3 | DNA strand elongation involved in DNA replication (GO:0006271) | 5.01407285 |
4 | DNA strand elongation (GO:0022616) | 4.75942053 |
5 | nuclear pore organization (GO:0006999) | 4.73921951 |
6 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.62980404 |
7 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.62980404 |
8 | protein localization to kinetochore (GO:0034501) | 4.54926883 |
9 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.47032239 |
10 | nuclear pore complex assembly (GO:0051292) | 4.46805592 |
11 | IMP biosynthetic process (GO:0006188) | 4.25396077 |
12 | nucleobase biosynthetic process (GO:0046112) | 4.25076926 |
13 | formation of translation preinitiation complex (GO:0001731) | 4.16723080 |
14 | mitotic nuclear envelope disassembly (GO:0007077) | 4.15054118 |
15 | DNA replication checkpoint (GO:0000076) | 4.07178238 |
16 | DNA duplex unwinding (GO:0032508) | 4.02544675 |
17 | DNA geometric change (GO:0032392) | 4.01987877 |
18 | regulation of posttranscriptional gene silencing (GO:0060147) | 4.01676300 |
19 | regulation of gene silencing by miRNA (GO:0060964) | 4.01676300 |
20 | regulation of gene silencing by RNA (GO:0060966) | 4.01676300 |
21 | telomere maintenance via recombination (GO:0000722) | 3.98570612 |
22 | mitotic recombination (GO:0006312) | 3.98416550 |
23 | mitotic metaphase plate congression (GO:0007080) | 3.98271795 |
24 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.97014109 |
25 | establishment of viral latency (GO:0019043) | 3.96334672 |
26 | maturation of SSU-rRNA (GO:0030490) | 3.90097123 |
27 | nuclear envelope disassembly (GO:0051081) | 3.87147600 |
28 | membrane disassembly (GO:0030397) | 3.87147600 |
29 | DNA double-strand break processing (GO:0000729) | 3.86032929 |
30 | purine nucleobase biosynthetic process (GO:0009113) | 3.85246419 |
31 | non-recombinational repair (GO:0000726) | 3.85219171 |
32 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.85219171 |
33 | protein localization to chromosome, centromeric region (GO:0071459) | 3.80167839 |
34 | DNA ligation (GO:0006266) | 3.73748346 |
35 | IMP metabolic process (GO:0046040) | 3.73064686 |
36 | telomere maintenance via telomere lengthening (GO:0010833) | 3.71953643 |
37 | mitotic chromosome condensation (GO:0007076) | 3.68780175 |
38 | metaphase plate congression (GO:0051310) | 3.67348412 |
39 | L-serine metabolic process (GO:0006563) | 3.66814570 |
40 | mitotic sister chromatid segregation (GO:0000070) | 3.65505373 |
41 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.61958473 |
42 | regulation of histone H3-K9 methylation (GO:0051570) | 3.61518387 |
43 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.59812549 |
44 | chromatin remodeling at centromere (GO:0031055) | 3.59369830 |
45 | ribosomal small subunit assembly (GO:0000028) | 3.56805288 |
46 | regulation of centriole replication (GO:0046599) | 3.50134164 |
47 | ATP-dependent chromatin remodeling (GO:0043044) | 3.48679437 |
48 | negative regulation of histone methylation (GO:0031061) | 3.48630065 |
49 | kinetochore organization (GO:0051383) | 3.48483160 |
50 | ribosome assembly (GO:0042255) | 3.48010805 |
51 | pore complex assembly (GO:0046931) | 3.47945841 |
52 | sister chromatid segregation (GO:0000819) | 3.46985822 |
53 | CENP-A containing nucleosome assembly (GO:0034080) | 3.45680784 |
54 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.44420294 |
55 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.44420294 |
56 | regulation of sister chromatid segregation (GO:0033045) | 3.44420294 |
57 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.43151317 |
58 | DNA replication-independent nucleosome organization (GO:0034724) | 3.43151317 |
59 | heterochromatin organization (GO:0070828) | 3.42247111 |
60 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.42221906 |
61 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.42221906 |
62 | ribosome biogenesis (GO:0042254) | 3.41747327 |
63 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.40173596 |
64 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.36326344 |
65 | pre-miRNA processing (GO:0031054) | 3.32737709 |
66 | * somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.32040260 |
67 | * somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.32040260 |
68 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.31888335 |
69 | protein complex localization (GO:0031503) | 3.31404547 |
70 | establishment of chromosome localization (GO:0051303) | 3.27474872 |
71 | establishment of integrated proviral latency (GO:0075713) | 3.26493692 |
72 | DNA topological change (GO:0006265) | 3.26379023 |
73 | mitotic sister chromatid cohesion (GO:0007064) | 3.24125735 |
74 | DNA conformation change (GO:0071103) | 3.23264381 |
75 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.22686897 |
76 | negative regulation of chromosome segregation (GO:0051985) | 3.22286945 |
77 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.19185308 |
78 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.18916432 |
79 | protein K6-linked ubiquitination (GO:0085020) | 3.18627666 |
80 | regulation of spindle organization (GO:0090224) | 3.18574256 |
81 | positive regulation of chromosome segregation (GO:0051984) | 3.18185747 |
82 | replication fork processing (GO:0031297) | 3.18049060 |
83 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.16325507 |
84 | chromatin assembly or disassembly (GO:0006333) | 3.16115087 |
85 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.15676022 |
86 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.15676022 |
87 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.15676022 |
88 | negative regulation of sister chromatid segregation (GO:0033046) | 3.15676022 |
89 | DNA strand renaturation (GO:0000733) | 3.15067706 |
90 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.14444307 |
91 | spindle assembly checkpoint (GO:0071173) | 3.14125920 |
92 | regulation of chromosome segregation (GO:0051983) | 3.12666926 |
93 | viral transcription (GO:0019083) | 3.12475481 |
94 | translational termination (GO:0006415) | 3.11530394 |
95 | regulation of centrosome cycle (GO:0046605) | 3.11477302 |
96 | ribosomal large subunit biogenesis (GO:0042273) | 3.11060572 |
97 | negative regulation of mitosis (GO:0045839) | 3.10966581 |
98 | mitotic spindle assembly checkpoint (GO:0007094) | 3.10948730 |
99 | spindle checkpoint (GO:0031577) | 3.09300534 |
100 | base-excision repair (GO:0006284) | 3.09060200 |
101 | translesion synthesis (GO:0019985) | 3.09050973 |
102 | kinetochore assembly (GO:0051382) | 3.08825671 |
103 | mitotic G2/M transition checkpoint (GO:0044818) | 3.08723316 |
104 | chromatin assembly (GO:0031497) | 3.08376263 |
105 | regulation of sister chromatid cohesion (GO:0007063) | 3.07383691 |
106 | histone exchange (GO:0043486) | 3.07326894 |
107 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.06316945 |
108 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.06230429 |
109 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.05873366 |
110 | telomere maintenance (GO:0000723) | 3.04426304 |
111 | regulation of translational fidelity (GO:0006450) | 3.04062799 |
112 | mitotic spindle checkpoint (GO:0071174) | 3.03852858 |
113 | telomere organization (GO:0032200) | 3.03618661 |
114 | proteasome assembly (GO:0043248) | 3.03167553 |
115 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.03164032 |
116 | translational initiation (GO:0006413) | 3.01316434 |
117 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.98537756 |
118 | meiotic chromosome segregation (GO:0045132) | 2.98504855 |
119 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.98355520 |
120 | dosage compensation (GO:0007549) | 2.97530021 |
121 | nuclear envelope organization (GO:0006998) | 2.97443723 |
122 | regulation of DNA endoreduplication (GO:0032875) | 2.96949477 |
123 | * mismatch repair (GO:0006298) | 2.96592846 |
124 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.96405107 |
125 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.96149528 |
126 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.95799170 |
127 | histone arginine methylation (GO:0034969) | 2.95123279 |
128 | DNA damage response, detection of DNA damage (GO:0042769) | 2.94613382 |
129 | negative regulation of mRNA processing (GO:0050686) | 2.94095044 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * E2F7_22180533_ChIP-Seq_HELA_Human | 9.94734802 |
2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.32295818 |
3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.19000805 |
4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.90823649 |
5 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.26349947 |
6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.14009211 |
7 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.12324055 |
8 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.79753886 |
9 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.58834367 |
10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.39631404 |
11 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35475152 |
12 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.30826576 |
13 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.29664627 |
14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.24134782 |
15 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.22911777 |
16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.18913593 |
17 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.17756343 |
18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.17325292 |
19 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.10690300 |
20 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.10195570 |
21 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.09433708 |
22 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.08166606 |
23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.07348624 |
24 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.03723158 |
25 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.02999538 |
26 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.02163010 |
27 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 2.00284208 |
28 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.99669736 |
29 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.93580761 |
30 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.88631354 |
31 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.87592959 |
32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.85042047 |
33 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.82204915 |
34 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.82204915 |
35 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.82204915 |
36 | MYC_22102868_ChIP-Seq_BL_Human | 1.75237447 |
37 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.73316351 |
38 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.68440091 |
39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.65539146 |
40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.64471622 |
41 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.63485168 |
42 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.62285999 |
43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.62036025 |
44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.60620893 |
45 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58051713 |
46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.56656284 |
47 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.56507727 |
48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.53250937 |
49 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.53014868 |
50 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.51068413 |
51 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.50978783 |
52 | * NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.49904352 |
53 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.48580600 |
54 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.48282433 |
55 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.46261262 |
56 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41623431 |
57 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.41366102 |
58 | * TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.38957667 |
59 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.38593497 |
60 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.37888436 |
61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.37425897 |
62 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.36172279 |
63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.35293068 |
64 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34957856 |
65 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.33373392 |
66 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32610240 |
67 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.32591962 |
68 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.30950334 |
69 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.29716686 |
70 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.29713688 |
71 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.28648690 |
72 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.25688085 |
73 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25677710 |
74 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.25504901 |
75 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.24431927 |
76 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22443796 |
77 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.20925534 |
78 | EWS_26573619_Chip-Seq_HEK293_Human | 1.19925384 |
79 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.18157076 |
80 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.18006998 |
81 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.13931916 |
82 | FUS_26573619_Chip-Seq_HEK293_Human | 1.12067341 |
83 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.11781641 |
84 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.11200380 |
85 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.10400086 |
86 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.07193689 |
87 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.06665352 |
88 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06619456 |
89 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06050528 |
90 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.05488424 |
91 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05146960 |
92 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.04569760 |
93 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.02752253 |
94 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.98543312 |
95 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.98223069 |
96 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.97733366 |
97 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96585723 |
98 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.96250827 |
99 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95454201 |
100 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.94826157 |
101 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.94376282 |
102 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.93933516 |
103 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.92880402 |
104 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.91949129 |
105 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.91051327 |
106 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.90620355 |
107 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.89243068 |
108 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.88298084 |
109 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.84291787 |
110 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.84058326 |
111 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83626468 |
112 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.82470348 |
113 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.80794088 |
114 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.78943359 |
115 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.74483152 |
116 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.74091568 |
117 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.71111161 |
118 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.69944957 |
119 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.69525094 |
120 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.68023925 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0010094_abnormal_chromosome_stability | 5.09988135 |
2 | MP0003693_abnormal_embryo_hatching | 5.03754865 |
3 | MP0003111_abnormal_nucleus_morphology | 4.59565619 |
4 | MP0004957_abnormal_blastocyst_morpholog | 4.43734164 |
5 | MP0008057_abnormal_DNA_replication | 4.32972063 |
6 | * MP0003077_abnormal_cell_cycle | 4.00787018 |
7 | * MP0008058_abnormal_DNA_repair | 3.17082529 |
8 | MP0008007_abnormal_cellular_replicative | 2.78071781 |
9 | MP0003123_paternal_imprinting | 2.72869164 |
10 | MP0001730_embryonic_growth_arrest | 2.59172508 |
11 | MP0008932_abnormal_embryonic_tissue | 2.56665267 |
12 | MP0000350_abnormal_cell_proliferation | 2.48532626 |
13 | MP0008877_abnormal_DNA_methylation | 2.47975491 |
14 | MP0002396_abnormal_hematopoietic_system | 2.12508280 |
15 | MP0009697_abnormal_copulation | 2.10518791 |
16 | MP0001672_abnormal_embryogenesis/_devel | 2.00185861 |
17 | MP0005380_embryogenesis_phenotype | 2.00185861 |
18 | MP0003786_premature_aging | 1.93610367 |
19 | MP0003890_abnormal_embryonic-extraembry | 1.93128194 |
20 | MP0001697_abnormal_embryo_size | 1.93053134 |
21 | MP0003121_genomic_imprinting | 1.91310991 |
22 | MP0002084_abnormal_developmental_patter | 1.90562576 |
23 | MP0002085_abnormal_embryonic_tissue | 1.89221662 |
24 | * MP0010352_gastrointestinal_tract_polyps | 1.78503250 |
25 | MP0004197_abnormal_fetal_growth/weight/ | 1.77586424 |
26 | MP0003984_embryonic_growth_retardation | 1.75283342 |
27 | MP0002080_prenatal_lethality | 1.74854691 |
28 | MP0002088_abnormal_embryonic_growth/wei | 1.72612891 |
29 | MP0002086_abnormal_extraembryonic_tissu | 1.69244748 |
30 | MP0004133_heterotaxia | 1.67675138 |
31 | * MP0010307_abnormal_tumor_latency | 1.65121255 |
32 | MP0000490_abnormal_crypts_of | 1.62950296 |
33 | MP0001293_anophthalmia | 1.57310671 |
34 | MP0005076_abnormal_cell_differentiation | 1.52077822 |
35 | MP0003806_abnormal_nucleotide_metabolis | 1.49768331 |
36 | MP0002653_abnormal_ependyma_morphology | 1.47518370 |
37 | MP0010030_abnormal_orbit_morphology | 1.47191748 |
38 | * MP0000313_abnormal_cell_death | 1.46032935 |
39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.43809607 |
40 | MP0004808_abnormal_hematopoietic_stem | 1.42253424 |
41 | MP0006035_abnormal_mitochondrial_morpho | 1.41905900 |
42 | MP0000537_abnormal_urethra_morphology | 1.40116411 |
43 | MP0001188_hyperpigmentation | 1.37623927 |
44 | * MP0002019_abnormal_tumor_incidence | 1.37423066 |
45 | MP0003119_abnormal_digestive_system | 1.35546962 |
46 | MP0006292_abnormal_olfactory_placode | 1.32200431 |
47 | MP0002210_abnormal_sex_determination | 1.31417638 |
48 | MP0002254_reproductive_system_inflammat | 1.27759021 |
49 | MP0001529_abnormal_vocalization | 1.25996824 |
50 | MP0003315_abnormal_perineum_morphology | 1.25674728 |
51 | MP0002938_white_spotting | 1.23158226 |
52 | MP0001145_abnormal_male_reproductive | 1.20191388 |
53 | MP0003718_maternal_effect | 1.18891280 |
54 | MP0002233_abnormal_nose_morphology | 1.15912076 |
55 | MP0008789_abnormal_olfactory_epithelium | 1.08989197 |
56 | MP0004264_abnormal_extraembryonic_tissu | 1.08118228 |
57 | MP0000703_abnormal_thymus_morphology | 1.07459059 |
58 | MP0000579_abnormal_nail_morphology | 1.06206333 |
59 | MP0002102_abnormal_ear_morphology | 1.05438486 |
60 | MP0003283_abnormal_digestive_organ | 1.02648035 |
61 | MP0003136_yellow_coat_color | 1.01524648 |
62 | MP0001177_atelectasis | 0.99828342 |
63 | MP0005394_taste/olfaction_phenotype | 0.99199729 |
64 | MP0005499_abnormal_olfactory_system | 0.99199729 |
65 | MP0003941_abnormal_skin_development | 0.98977197 |
66 | MP0002160_abnormal_reproductive_system | 0.98557702 |
67 | MP0001929_abnormal_gametogenesis | 0.98174673 |
68 | MP0000653_abnormal_sex_gland | 0.97068187 |
69 | MP0009672_abnormal_birth_weight | 0.96829145 |
70 | MP0001849_ear_inflammation | 0.96217659 |
71 | MP0009703_decreased_birth_body | 0.95225426 |
72 | MP0000049_abnormal_middle_ear | 0.94514195 |
73 | MP0002111_abnormal_tail_morphology | 0.94192879 |
74 | MP0009053_abnormal_anal_canal | 0.93464233 |
75 | MP0000566_synostosis | 0.91559135 |
76 | MP0003763_abnormal_thymus_physiology | 0.89927748 |
77 | MP0001545_abnormal_hematopoietic_system | 0.89592818 |
78 | MP0005397_hematopoietic_system_phenotyp | 0.89592818 |
79 | MP0003937_abnormal_limbs/digits/tail_de | 0.88670591 |
80 | MP0008995_early_reproductive_senescence | 0.87030575 |
81 | MP0002751_abnormal_autonomic_nervous | 0.86833787 |
82 | MP0003787_abnormal_imprinting | 0.83556828 |
83 | MP0000358_abnormal_cell_content/ | 0.83474272 |
84 | MP0002092_abnormal_eye_morphology | 0.83085152 |
85 | MP0001286_abnormal_eye_development | 0.82489145 |
86 | MP0009278_abnormal_bone_marrow | 0.82124861 |
87 | * MP0005384_cellular_phenotype | 0.81705358 |
88 | MP0004147_increased_porphyrin_level | 0.81235194 |
89 | MP0005389_reproductive_system_phenotype | 0.80781877 |
90 | MP0002722_abnormal_immune_system | 0.80404630 |
91 | MP0001299_abnormal_eye_distance/ | 0.79583585 |
92 | MP0003566_abnormal_cell_adhesion | 0.77205618 |
93 | MP0003122_maternal_imprinting | 0.76729546 |
94 | MP0000647_abnormal_sebaceous_gland | 0.76199404 |
95 | MP0003705_abnormal_hypodermis_morpholog | 0.75845418 |
96 | * MP0002398_abnormal_bone_marrow | 0.75573426 |
97 | MP0000428_abnormal_craniofacial_morphol | 0.75377439 |
98 | MP0003861_abnormal_nervous_system | 0.75206270 |
99 | MP0001119_abnormal_female_reproductive | 0.73773847 |
100 | MP0001915_intracranial_hemorrhage | 0.73477835 |
101 | * MP0005621_abnormal_cell_physiology | 0.72875314 |
102 | MP0005023_abnormal_wound_healing | 0.72587440 |
103 | MP0000689_abnormal_spleen_morphology | 0.71218286 |
104 | MP0009333_abnormal_splenocyte_physiolog | 0.71211643 |
105 | MP0002075_abnormal_coat/hair_pigmentati | 0.71038642 |
106 | MP0003755_abnormal_palate_morphology | 0.70316284 |
107 | MP0002796_impaired_skin_barrier | 0.69608629 |
108 | MP0002697_abnormal_eye_size | 0.68969790 |
109 | MP0005395_other_phenotype | 0.68875357 |
110 | MP0001346_abnormal_lacrimal_gland | 0.68479076 |
111 | MP0003698_abnormal_male_reproductive | 0.68410587 |
112 | * MP0000477_abnormal_intestine_morphology | 0.66875819 |
113 | MP0005391_vision/eye_phenotype | 0.66263295 |
114 | MP0006072_abnormal_retinal_apoptosis | 0.66065367 |
115 | MP0000432_abnormal_head_morphology | 0.65111129 |
116 | MP0006036_abnormal_mitochondrial_physio | 0.64227212 |
117 | MP0005075_abnormal_melanosome_morpholog | 0.63392634 |
118 | MP0000631_abnormal_neuroendocrine_gland | 0.63079045 |
119 | MP0003935_abnormal_craniofacial_develop | 0.63000545 |
120 | MP0000858_altered_metastatic_potential | 0.62936394 |
121 | MP0002161_abnormal_fertility/fecundity | 0.62302038 |
122 | MP0004233_abnormal_muscle_weight | 0.61410814 |
123 | MP0002081_perinatal_lethality | 0.61267761 |
124 | MP0000516_abnormal_urinary_system | 0.60792853 |
125 | MP0005367_renal/urinary_system_phenotyp | 0.60792853 |
126 | MP0002234_abnormal_pharynx_morphology | 0.60497016 |
127 | MP0003699_abnormal_female_reproductive | 0.60428476 |
128 | MP0000371_diluted_coat_color | 0.59898759 |
129 | MP0005266_abnormal_metabolism | 0.59826331 |
130 | MP0002090_abnormal_vision | 0.59019697 |
131 | MP0002925_abnormal_cardiovascular_devel | 0.58742632 |
132 | MP0005501_abnormal_skin_physiology | 0.58638435 |
133 | MP0003186_abnormal_redox_activity | 0.57390299 |
134 | MP0003115_abnormal_respiratory_system | 0.57001653 |
135 | MP0001919_abnormal_reproductive_system | 0.56702423 |
136 | MP0002114_abnormal_axial_skeleton | 0.55833056 |
137 | MP0003221_abnormal_cardiomyocyte_apopto | 0.55632415 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Birth length less than 3rd percentile (HP:0003561) | 4.52433212 |
2 | Chromsome breakage (HP:0040012) | 4.39893420 |
3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.20239523 |
4 | * Ependymoma (HP:0002888) | 4.01019844 |
5 | * Medulloblastoma (HP:0002885) | 3.89317186 |
6 | Selective tooth agenesis (HP:0001592) | 3.69350202 |
7 | Reticulocytopenia (HP:0001896) | 3.66128457 |
8 | Abnormality of chromosome stability (HP:0003220) | 3.60675948 |
9 | Abnormality of the labia minora (HP:0012880) | 3.54768177 |
10 | Breast hypoplasia (HP:0003187) | 3.49143399 |
11 | Meckel diverticulum (HP:0002245) | 3.41131753 |
12 | Abnormality of the ileum (HP:0001549) | 3.30182923 |
13 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.28525688 |
14 | Cortical dysplasia (HP:0002539) | 3.28184198 |
15 | Abnormality of the preputium (HP:0100587) | 3.24185259 |
16 | Patellar aplasia (HP:0006443) | 3.18075317 |
17 | Supernumerary spleens (HP:0009799) | 3.06408659 |
18 | Absent thumb (HP:0009777) | 3.02082757 |
19 | Oral leukoplakia (HP:0002745) | 3.01414487 |
20 | Absent radius (HP:0003974) | 2.96076262 |
21 | Abnormal number of incisors (HP:0011064) | 2.94514104 |
22 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.93842774 |
23 | Myelodysplasia (HP:0002863) | 2.87450550 |
24 | Small intestinal stenosis (HP:0012848) | 2.84743129 |
25 | Duodenal stenosis (HP:0100867) | 2.84743129 |
26 | Aplastic anemia (HP:0001915) | 2.81868934 |
27 | Multiple enchondromatosis (HP:0005701) | 2.79983413 |
28 | Degeneration of anterior horn cells (HP:0002398) | 2.78017737 |
29 | Abnormality of the anterior horn cell (HP:0006802) | 2.78017737 |
30 | Aplasia involving forearm bones (HP:0009822) | 2.76363444 |
31 | Absent forearm bone (HP:0003953) | 2.76363444 |
32 | Increased nuchal translucency (HP:0010880) | 2.74313626 |
33 | Carpal bone hypoplasia (HP:0001498) | 2.73621404 |
34 | Volvulus (HP:0002580) | 2.72689577 |
35 | Impulsivity (HP:0100710) | 2.71790863 |
36 | Proximal placement of thumb (HP:0009623) | 2.70327799 |
37 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.62589330 |
38 | Missing ribs (HP:0000921) | 2.58320358 |
39 | * Astrocytoma (HP:0009592) | 2.56695026 |
40 | * Abnormality of the astrocytes (HP:0100707) | 2.56695026 |
41 | Deviation of the thumb (HP:0009603) | 2.56225904 |
42 | * Colon cancer (HP:0003003) | 2.55686239 |
43 | Spastic diplegia (HP:0001264) | 2.55464071 |
44 | * Rhabdomyosarcoma (HP:0002859) | 2.51925829 |
45 | * Neoplasm of the oral cavity (HP:0100649) | 2.50282982 |
46 | Abnormality of the duodenum (HP:0002246) | 2.47292784 |
47 | Sloping forehead (HP:0000340) | 2.46198502 |
48 | Bone marrow hypocellularity (HP:0005528) | 2.43732843 |
49 | Abdominal situs inversus (HP:0003363) | 2.41667740 |
50 | Abnormality of abdominal situs (HP:0011620) | 2.41667740 |
51 | * Neoplasm of the pancreas (HP:0002894) | 2.41117377 |
52 | Abnormality of the carotid arteries (HP:0005344) | 2.39952431 |
53 | 11 pairs of ribs (HP:0000878) | 2.38485466 |
54 | Abnormal lung lobation (HP:0002101) | 2.38154104 |
55 | Ectopic kidney (HP:0000086) | 2.37893471 |
56 | Tracheoesophageal fistula (HP:0002575) | 2.37697021 |
57 | Rough bone trabeculation (HP:0100670) | 2.36888710 |
58 | Rib fusion (HP:0000902) | 2.33768890 |
59 | Abnormal number of erythroid precursors (HP:0012131) | 2.31983090 |
60 | Asplenia (HP:0001746) | 2.31376171 |
61 | * Agnosia (HP:0010524) | 2.31347959 |
62 | Esophageal atresia (HP:0002032) | 2.30965845 |
63 | Microvesicular hepatic steatosis (HP:0001414) | 2.30550560 |
64 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.29347957 |
65 | * Glioma (HP:0009733) | 2.28279694 |
66 | Septo-optic dysplasia (HP:0100842) | 2.27819879 |
67 | Atresia of the external auditory canal (HP:0000413) | 2.27312780 |
68 | Premature graying of hair (HP:0002216) | 2.26346377 |
69 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.25397746 |
70 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.24416831 |
71 | * Basal cell carcinoma (HP:0002671) | 2.23969922 |
72 | Cerebral hypomyelination (HP:0006808) | 2.23693704 |
73 | Hyperglycinemia (HP:0002154) | 2.22886166 |
74 | * Cafe-au-lait spot (HP:0000957) | 2.18915564 |
75 | Horseshoe kidney (HP:0000085) | 2.13607826 |
76 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.12919537 |
77 | Prominent nose (HP:0000448) | 2.11947619 |
78 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.11868746 |
79 | * Neoplasm of striated muscle (HP:0009728) | 2.11718720 |
80 | Cellular immunodeficiency (HP:0005374) | 2.08584862 |
81 | Abnormality of cochlea (HP:0000375) | 2.07693876 |
82 | Embryonal neoplasm (HP:0002898) | 2.07507008 |
83 | High anterior hairline (HP:0009890) | 2.07428361 |
84 | Embryonal renal neoplasm (HP:0011794) | 2.06897100 |
85 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.05206801 |
86 | Short thumb (HP:0009778) | 2.04827866 |
87 | Triphalangeal thumb (HP:0001199) | 2.03762635 |
88 | Abnormality of serum amino acid levels (HP:0003112) | 2.03724242 |
89 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.02520573 |
90 | Short humerus (HP:0005792) | 2.02411603 |
91 | High pitched voice (HP:0001620) | 1.98783926 |
92 | Duplicated collecting system (HP:0000081) | 1.98436164 |
93 | Abnormality of the septum pellucidum (HP:0007375) | 1.97480129 |
94 | Neoplasm of the adrenal cortex (HP:0100641) | 1.94360570 |
95 | * Neoplasm of the colon (HP:0100273) | 1.93755063 |
96 | Trismus (HP:0000211) | 1.93717832 |
97 | Choanal atresia (HP:0000453) | 1.93656033 |
98 | Neoplasm of the adrenal gland (HP:0100631) | 1.93631047 |
99 | Stenosis of the external auditory canal (HP:0000402) | 1.93586151 |
100 | Bifid tongue (HP:0010297) | 1.93388128 |
101 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.93278103 |
102 | * Ovarian neoplasm (HP:0100615) | 1.92051019 |
103 | Clubbing of toes (HP:0100760) | 1.91881502 |
104 | Pallor (HP:0000980) | 1.91678166 |
105 | * Biliary tract neoplasm (HP:0100574) | 1.91367439 |
106 | Abnormality of methionine metabolism (HP:0010901) | 1.91134141 |
107 | Squamous cell carcinoma (HP:0002860) | 1.90905735 |
108 | Microretrognathia (HP:0000308) | 1.90004005 |
109 | Shawl scrotum (HP:0000049) | 1.89608253 |
110 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.89119422 |
111 | Premature ovarian failure (HP:0008209) | 1.88069818 |
112 | Facial cleft (HP:0002006) | 1.87917322 |
113 | Macrocytic anemia (HP:0001972) | 1.87854653 |
114 | Spinal muscular atrophy (HP:0007269) | 1.87137517 |
115 | Absent septum pellucidum (HP:0001331) | 1.87048385 |
116 | Gastrointestinal atresia (HP:0002589) | 1.86295652 |
117 | Facial hemangioma (HP:0000329) | 1.86179156 |
118 | Abnormality of glycolysis (HP:0004366) | 1.85178401 |
119 | Short 4th metacarpal (HP:0010044) | 1.84459893 |
120 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.84459893 |
121 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.83618686 |
122 | Abnormality of glycine metabolism (HP:0010895) | 1.83618686 |
123 | Increased serum pyruvate (HP:0003542) | 1.82431002 |
124 | Abnormality of DNA repair (HP:0003254) | 1.81850126 |
125 | Clitoromegaly (HP:0000057) | 1.79563045 |
126 | Abnormality of the clitoris (HP:0000056) | 1.79205995 |
127 | Progressive external ophthalmoplegia (HP:0000590) | 1.77522671 |
128 | Duplication of thumb phalanx (HP:0009942) | 1.75398892 |
129 | Postnatal microcephaly (HP:0005484) | 1.74946735 |
130 | Intestinal atresia (HP:0011100) | 1.73558401 |
131 | Bilateral microphthalmos (HP:0007633) | 1.73076176 |
132 | Hyperglycinuria (HP:0003108) | 1.72678923 |
133 | Gonadotropin excess (HP:0000837) | 1.72095850 |
134 | Acute encephalopathy (HP:0006846) | 1.70135351 |
135 | Arteriovenous malformation (HP:0100026) | 1.66566295 |
136 | Hepatoblastoma (HP:0002884) | 1.66175024 |
137 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.65418749 |
138 | Increased hepatocellular lipid droplets (HP:0006565) | 1.65234287 |
139 | Abnormal hair whorl (HP:0010721) | 1.64463978 |
140 | Shoulder girdle muscle weakness (HP:0003547) | 1.59112990 |
141 | Aqueductal stenosis (HP:0002410) | 1.59059642 |
142 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.56379653 |
143 | Hypoplastic female external genitalia (HP:0012815) | 1.54694467 |
144 | Breast aplasia (HP:0100783) | 1.54666050 |
145 | Megaloblastic anemia (HP:0001889) | 1.54321855 |
146 | Hypoglycemic seizures (HP:0002173) | 1.53819436 |
147 | Acute necrotizing encephalopathy (HP:0006965) | 1.53737763 |
148 | Abnormality of homocysteine metabolism (HP:0010919) | 1.53276591 |
Rank | Gene Set | Z-score |
---|---|---|
1 | CDC7 | 4.90783501 |
2 | WEE1 | 4.42248574 |
3 | BUB1 | 3.70694679 |
4 | CDK12 | 3.06552912 |
5 | NEK2 | 2.79341174 |
6 | PBK | 2.78571977 |
7 | TTK | 2.77903917 |
8 | NEK1 | 2.75756364 |
9 | TSSK6 | 2.74568067 |
10 | EEF2K | 2.65431959 |
11 | RPS6KB2 | 2.46521698 |
12 | VRK2 | 2.45652816 |
13 | PASK | 2.35452721 |
14 | SRPK1 | 2.31280098 |
15 | ACVR1B | 2.23709301 |
16 | PLK1 | 2.10071479 |
17 | CDK7 | 2.08673279 |
18 | TRIM28 | 2.06272348 |
19 | TAF1 | 2.02969650 |
20 | ATR | 2.00567184 |
21 | EPHA2 | 1.90024587 |
22 | EIF2AK1 | 1.86539217 |
23 | NUAK1 | 1.78604159 |
24 | MKNK1 | 1.72069832 |
25 | AURKB | 1.66361940 |
26 | BRSK2 | 1.64091725 |
27 | CHEK2 | 1.62775226 |
28 | TGFBR1 | 1.62238326 |
29 | BRD4 | 1.61659430 |
30 | PLK3 | 1.59646732 |
31 | CDK4 | 1.55914923 |
32 | MST4 | 1.54093884 |
33 | TNIK | 1.48523054 |
34 | MAP3K10 | 1.48190138 |
35 | DYRK3 | 1.48081700 |
36 | TLK1 | 1.47590201 |
37 | CHEK1 | 1.47450254 |
38 | TESK2 | 1.42798509 |
39 | PLK4 | 1.42788673 |
40 | VRK1 | 1.39167339 |
41 | WNK3 | 1.38225458 |
42 | SCYL2 | 1.34963060 |
43 | MAP3K8 | 1.34633095 |
44 | EIF2AK3 | 1.31811053 |
45 | FLT3 | 1.29430424 |
46 | STK10 | 1.27900530 |
47 | AURKA | 1.27467246 |
48 | PAK4 | 1.21762594 |
49 | MKNK2 | 1.19631568 |
50 | RPS6KA4 | 1.18112744 |
51 | MAPKAPK3 | 1.13423639 |
52 | ATM | 1.13154388 |
53 | STK4 | 1.12470096 |
54 | CDK2 | 1.07546714 |
55 | PKN2 | 1.06772375 |
56 | PNCK | 1.06746788 |
57 | BRSK1 | 1.05826843 |
58 | BCR | 1.03773039 |
59 | EIF2AK2 | 1.01000058 |
60 | NME1 | 1.00546335 |
61 | ALK | 1.00073257 |
62 | STK16 | 0.91195099 |
63 | LATS1 | 0.90127398 |
64 | PIM1 | 0.88754180 |
65 | NME2 | 0.88192047 |
66 | CSNK1G1 | 0.87765429 |
67 | SMG1 | 0.87740242 |
68 | CDK6 | 0.87679788 |
69 | BMPR1B | 0.82934504 |
70 | CCNB1 | 0.81162934 |
71 | CDK1 | 0.79751090 |
72 | DYRK2 | 0.77489461 |
73 | ERBB4 | 0.75274511 |
74 | CSNK2A2 | 0.74244350 |
75 | PRKCI | 0.72592975 |
76 | CSNK1G3 | 0.68226216 |
77 | ZAK | 0.66548644 |
78 | CDK8 | 0.65614221 |
79 | MELK | 0.64778442 |
80 | CSNK1G2 | 0.64592650 |
81 | MTOR | 0.64220725 |
82 | CSNK2A1 | 0.60297560 |
83 | AKT3 | 0.56626082 |
84 | PLK2 | 0.55578053 |
85 | CSNK1A1L | 0.53955386 |
86 | CSNK1E | 0.53066516 |
87 | MAP3K4 | 0.52540560 |
88 | PAK1 | 0.52212059 |
89 | MAP4K1 | 0.51619814 |
90 | PRKDC | 0.48768579 |
91 | DAPK1 | 0.47226325 |
92 | CSNK1D | 0.45609861 |
93 | AKT2 | 0.44433076 |
94 | LRRK2 | 0.43630862 |
95 | CDK3 | 0.42683628 |
96 | LATS2 | 0.42477565 |
97 | PDK2 | 0.40832902 |
98 | RPS6KA5 | 0.39771888 |
99 | GRK6 | 0.38940774 |
100 | CDK18 | 0.38793287 |
101 | MAPK14 | 0.38610672 |
102 | CDK19 | 0.37574058 |
103 | YES1 | 0.34856775 |
104 | ERBB3 | 0.34306199 |
105 | FGFR1 | 0.33933022 |
106 | CDK15 | 0.33741903 |
107 | STK3 | 0.32835667 |
108 | MINK1 | 0.32694518 |
109 | CDK11A | 0.32668839 |
110 | RPS6KB1 | 0.32263705 |
111 | MAP2K3 | 0.31434051 |
112 | CDK14 | 0.31067184 |
113 | CLK1 | 0.30385974 |
114 | AKT1 | 0.30138845 |
115 | GSK3B | 0.28781403 |
116 | STK38L | 0.28250056 |
117 | BRAF | 0.26353535 |
118 | OXSR1 | 0.26225029 |
119 | FGFR2 | 0.26210919 |
120 | CDK9 | 0.25434802 |
121 | MAPK1 | 0.25426367 |
122 | MAPK11 | 0.25083120 |
123 | MAP4K2 | 0.24711904 |
124 | TAOK2 | 0.23987836 |
125 | RPS6KA1 | 0.21576963 |
126 | MATK | 0.21488991 |
127 | CSF1R | 0.18536580 |
128 | PAK2 | 0.18034776 |
129 | BTK | 0.17171529 |
130 | PDK4 | 0.17068357 |
131 | PDK3 | 0.17068357 |
132 | RPS6KL1 | 0.16946026 |
133 | RPS6KC1 | 0.16946026 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 5.41961858 |
2 | * Mismatch repair_Homo sapiens_hsa03430 | 4.72597177 |
3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.72422138 |
4 | Spliceosome_Homo sapiens_hsa03040 | 3.50183205 |
5 | RNA transport_Homo sapiens_hsa03013 | 3.32081925 |
6 | Homologous recombination_Homo sapiens_hsa03440 | 3.24384378 |
7 | Base excision repair_Homo sapiens_hsa03410 | 3.22449843 |
8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 3.07103273 |
9 | Cell cycle_Homo sapiens_hsa04110 | 2.98987055 |
10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.98113204 |
11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.90382257 |
12 | Ribosome_Homo sapiens_hsa03010 | 2.88373926 |
13 | RNA polymerase_Homo sapiens_hsa03020 | 2.62465782 |
14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.60514475 |
15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.45205254 |
16 | Proteasome_Homo sapiens_hsa03050 | 2.40055001 |
17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.14713167 |
18 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.06980866 |
19 | RNA degradation_Homo sapiens_hsa03018 | 2.01560650 |
20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.78353409 |
21 | Protein export_Homo sapiens_hsa03060 | 1.69166056 |
22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.59699190 |
23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.51959227 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.45482491 |
25 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.43290257 |
26 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.42511770 |
27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.39625262 |
28 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.37880919 |
29 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.32951817 |
30 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.23645105 |
31 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.15162076 |
32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.11553919 |
33 | Purine metabolism_Homo sapiens_hsa00230 | 1.11367584 |
34 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.08581628 |
35 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.03812848 |
36 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.00509969 |
37 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.99468582 |
38 | Parkinsons disease_Homo sapiens_hsa05012 | 0.92898261 |
39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.92032157 |
40 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.89820064 |
41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.88176735 |
42 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.86455743 |
43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.85519885 |
44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84082005 |
45 | HTLV-I infection_Homo sapiens_hsa05166 | 0.81459981 |
46 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.80621344 |
47 | Thyroid cancer_Homo sapiens_hsa05216 | 0.79330259 |
48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.78507613 |
49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.77515330 |
50 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.76106852 |
51 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.71408672 |
52 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.70299401 |
53 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.69018980 |
54 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.66041888 |
55 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.64083536 |
56 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.63717292 |
57 | Alcoholism_Homo sapiens_hsa05034 | 0.61483032 |
58 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.60557399 |
59 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.59628281 |
60 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.59114695 |
61 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.57098850 |
62 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.57054448 |
63 | * Colorectal cancer_Homo sapiens_hsa05210 | 0.54648120 |
64 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.53118486 |
65 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.52727358 |
66 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.52237417 |
67 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.51695295 |
68 | Carbon metabolism_Homo sapiens_hsa01200 | 0.48655023 |
69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.47486295 |
70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46994984 |
71 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.44282939 |
72 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.43571941 |
73 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.42859340 |
74 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.42545518 |
75 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.41823455 |
76 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.41242495 |
77 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.40726183 |
78 | Legionellosis_Homo sapiens_hsa05134 | 0.40456766 |
79 | Adherens junction_Homo sapiens_hsa04520 | 0.38308643 |
80 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38260301 |
81 | Bladder cancer_Homo sapiens_hsa05219 | 0.37623420 |
82 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.36538366 |
83 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.36389675 |
84 | Lysine degradation_Homo sapiens_hsa00310 | 0.34806663 |
85 | Alzheimers disease_Homo sapiens_hsa05010 | 0.34557655 |
86 | * Pathways in cancer_Homo sapiens_hsa05200 | 0.34209988 |
87 | Apoptosis_Homo sapiens_hsa04210 | 0.33952016 |
88 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.31657827 |
89 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.30787107 |
90 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.29470178 |
91 | Hepatitis B_Homo sapiens_hsa05161 | 0.28188522 |
92 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.28154027 |
93 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.28060869 |
94 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.26770626 |
95 | Sulfur relay system_Homo sapiens_hsa04122 | 0.26169257 |
96 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25867002 |
97 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.25280146 |
98 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.24154576 |
99 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.23897659 |
100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.23466501 |
101 | Tight junction_Homo sapiens_hsa04530 | 0.23080201 |
102 | Shigellosis_Homo sapiens_hsa05131 | 0.22527146 |
103 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.19994769 |
104 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.19618683 |
105 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.19189000 |
106 | Endometrial cancer_Homo sapiens_hsa05213 | 0.18742350 |
107 | Prostate cancer_Homo sapiens_hsa05215 | 0.18719389 |
108 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.18718836 |
109 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.17872836 |
110 | Viral myocarditis_Homo sapiens_hsa05416 | 0.17433577 |
111 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.17373185 |
112 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.15645642 |
113 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.15086458 |
114 | Melanoma_Homo sapiens_hsa05218 | 0.14785218 |
115 | Measles_Homo sapiens_hsa05162 | 0.12630634 |
116 | Influenza A_Homo sapiens_hsa05164 | 0.10503365 |
117 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.09697490 |
118 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.09665155 |
119 | Peroxisome_Homo sapiens_hsa04146 | 0.09560499 |
120 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.09547928 |
121 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.09435412 |
122 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.07440575 |
123 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.06619385 |
124 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.05992736 |
125 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.04542083 |
126 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.04067141 |
127 | Huntingtons disease_Homo sapiens_hsa05016 | 0.03993772 |
128 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.02730775 |
129 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.02540448 |
130 | Taste transduction_Homo sapiens_hsa04742 | 0.02059545 |
131 | Nicotine addiction_Homo sapiens_hsa05033 | 0.01532148 |
132 | Phototransduction_Homo sapiens_hsa04744 | 0.01312364 |
133 | Tryptophan metabolism_Homo sapiens_hsa00380 | -0.0011854 |