MSH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)5.07932881
2negative regulation of DNA-dependent DNA replication (GO:2000104)4.99744178
3centriole assembly (GO:0098534)4.47040920
4kinetochore organization (GO:0051383)4.31800136
5microtubule depolymerization (GO:0007019)4.21701981
6mitotic sister chromatid cohesion (GO:0007064)4.19980533
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.03221346
8protein K6-linked ubiquitination (GO:0085020)3.99892636
9histone H3-K4 trimethylation (GO:0080182)3.93567560
10kinetochore assembly (GO:0051382)3.90123887
11DNA unwinding involved in DNA replication (GO:0006268)3.88144581
12nuclear pore complex assembly (GO:0051292)3.80156530
13regulation of meiosis I (GO:0060631)3.79129591
14chromatin remodeling at centromere (GO:0031055)3.77684693
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.75314558
16meiotic chromosome segregation (GO:0045132)3.74266401
17CENP-A containing nucleosome assembly (GO:0034080)3.74222629
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68411198
19non-recombinational repair (GO:0000726)3.64708445
20double-strand break repair via nonhomologous end joining (GO:0006303)3.64708445
21attachment of spindle microtubules to kinetochore (GO:0008608)3.60422535
22regulation of DNA endoreduplication (GO:0032875)3.58318851
23telomere maintenance via telomerase (GO:0007004)3.53210051
24regulation of histone H3-K9 methylation (GO:0051570)3.53057217
25DNA strand elongation involved in DNA replication (GO:0006271)3.49061419
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.47553122
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47553122
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47553122
29mitotic metaphase plate congression (GO:0007080)3.44487791
30replication fork processing (GO:0031297)3.43224935
31mitotic chromosome condensation (GO:0007076)3.43118615
32negative regulation of histone methylation (GO:0031061)3.42427052
33DNA strand elongation (GO:0022616)3.41221466
34peptidyl-lysine trimethylation (GO:0018023)3.39695605
35metaphase plate congression (GO:0051310)3.36068877
36nuclear pore organization (GO:0006999)3.34880712
37DNA ligation (GO:0006266)3.33428662
38DNA double-strand break processing (GO:0000729)3.32970899
39protein localization to kinetochore (GO:0034501)3.31959451
40regulation of DNA damage checkpoint (GO:2000001)3.31324393
41regulation of DNA methylation (GO:0044030)3.30137363
42DNA replication-independent nucleosome assembly (GO:0006336)3.28952096
43DNA replication-independent nucleosome organization (GO:0034724)3.28952096
44DNA replication initiation (GO:0006270)3.28735130
45histone exchange (GO:0043486)3.28489277
46telomere maintenance via semi-conservative replication (GO:0032201)3.28114950
47histone H3-K9 methylation (GO:0051567)3.24090059
48regulation of telomere maintenance (GO:0032204)3.23827460
49regulation of DNA-dependent DNA replication (GO:0090329)3.23091578
50replicative senescence (GO:0090399)3.21611591
51epithelial cilium movement (GO:0003351)3.21417901
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.21106520
53establishment of integrated proviral latency (GO:0075713)3.20504361
54pre-miRNA processing (GO:0031054)3.19603059
55mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17900185
56mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17900185
57mitotic recombination (GO:0006312)3.16449536
58intra-S DNA damage checkpoint (GO:0031573)3.16315873
59positive regulation of histone H3-K4 methylation (GO:0051571)3.15656939
60DNA topological change (GO:0006265)3.14555812
61sister chromatid cohesion (GO:0007062)3.13694908
62positive regulation of chromosome segregation (GO:0051984)3.13650044
63telomere maintenance via recombination (GO:0000722)3.12824394
64maturation of 5.8S rRNA (GO:0000460)3.11880210
65spindle checkpoint (GO:0031577)3.10311395
66translesion synthesis (GO:0019985)3.09298913
67V(D)J recombination (GO:0033151)3.05966388
68positive regulation of histone methylation (GO:0031062)3.05768642
69cilium movement (GO:0003341)3.03031592
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.02865502
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02865502
72centriole replication (GO:0007099)3.02065474
73intraciliary transport (GO:0042073)3.00369076
74pore complex assembly (GO:0046931)2.99891415
75regulation of histone H3-K27 methylation (GO:0061085)2.99615632
76protein localization to chromosome (GO:0034502)2.99350033
77postreplication repair (GO:0006301)2.97315410
78female gonad development (GO:0008585)2.97275764
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.96946965
80protein localization to chromosome, centromeric region (GO:0071459)2.95239940
81* reciprocal DNA recombination (GO:0035825)2.91709079
82* reciprocal meiotic recombination (GO:0007131)2.91709079
83synapsis (GO:0007129)2.91642978
84positive regulation of DNA-dependent DNA replication (GO:2000105)2.90802483
85regulation of histone methylation (GO:0031060)2.90665193
86mRNA splice site selection (GO:0006376)2.90006739
87regulation of telomere maintenance via telomerase (GO:0032210)2.88850520
88mitotic nuclear envelope disassembly (GO:0007077)2.87834401
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86627912
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86627912
91regulation of mitotic sister chromatid separation (GO:0010965)2.86065809
92regulation of mitotic sister chromatid segregation (GO:0033047)2.86065809
93regulation of sister chromatid segregation (GO:0033045)2.86065809
94response to X-ray (GO:0010165)2.86030752
95regulation of centriole replication (GO:0046599)2.85618776
96protein localization to microtubule cytoskeleton (GO:0072698)2.85533469
97meiotic cell cycle (GO:0051321)2.85347063
98RNA-dependent DNA replication (GO:0006278)2.85316305
99sister chromatid segregation (GO:0000819)2.85265020
100DNA synthesis involved in DNA repair (GO:0000731)2.84687828
101establishment of chromosome localization (GO:0051303)2.84520875
102DNA replication checkpoint (GO:0000076)2.83896046
103mitotic G2/M transition checkpoint (GO:0044818)2.83632623
104DNA geometric change (GO:0032392)2.83055943
105chromatin assembly or disassembly (GO:0006333)2.81684707
106resolution of meiotic recombination intermediates (GO:0000712)2.80220730
107regulation of gene expression by genetic imprinting (GO:0006349)2.80205794
108regulation of centrosome cycle (GO:0046605)2.80044612
109histone mRNA metabolic process (GO:0008334)2.79470903
110centrosome organization (GO:0051297)2.79449329
111histone H2A acetylation (GO:0043968)2.78380863
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78244555
113mitotic sister chromatid segregation (GO:0000070)2.77768000
114microtubule polymerization or depolymerization (GO:0031109)2.77298011
115ncRNA catabolic process (GO:0034661)2.77081274
116transcription elongation from RNA polymerase I promoter (GO:0006362)2.77032856
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.76330552
118regulation of chromatin silencing (GO:0031935)2.76158166
119regulation of mitotic spindle checkpoint (GO:1903504)2.75926253
120regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75926253
121microtubule organizing center organization (GO:0031023)2.75165759
122regulation of centrosome duplication (GO:0010824)2.74953950
123* negative regulation of DNA recombination (GO:0045910)2.74840262
124mitotic spindle checkpoint (GO:0071174)2.74052499
125* mismatch repair (GO:0006298)2.72956229
126histone H3-K4 methylation (GO:0051568)2.72257596
127spindle assembly checkpoint (GO:0071173)2.71662328
128regulation of chromosome segregation (GO:0051983)2.71451798
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70926335
130DNA duplex unwinding (GO:0032508)2.69624962
131DNA replication-dependent nucleosome organization (GO:0034723)2.69253687
132DNA replication-dependent nucleosome assembly (GO:0006335)2.69253687
133* regulation of helicase activity (GO:0051095)2.69183648
134telomere maintenance via telomere lengthening (GO:0010833)2.68745778
135negative regulation of chromosome segregation (GO:0051985)2.68506489
136ATP-dependent chromatin remodeling (GO:0043044)2.68330965
137single strand break repair (GO:0000012)2.67763383
138histone H3-K9 modification (GO:0061647)2.67699425
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.67646000
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67646000
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67646000
142negative regulation of sister chromatid segregation (GO:0033046)2.67646000
143nuclear envelope disassembly (GO:0051081)2.67511711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.95392532
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38121522
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33496117
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.00022203
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.87777120
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.85068711
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54891846
8GBX2_23144817_ChIP-Seq_PC3_Human2.54729951
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54254696
10* ELK1_19687146_ChIP-ChIP_HELA_Human2.41255100
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.37903012
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36090006
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29025271
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27979008
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.22639673
16FUS_26573619_Chip-Seq_HEK293_Human2.17860539
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.17346428
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15441643
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10104390
20EWS_26573619_Chip-Seq_HEK293_Human2.07801804
21EZH2_22144423_ChIP-Seq_EOC_Human2.05096111
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99977862
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91237885
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89558591
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85468019
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83483198
27VDR_23849224_ChIP-Seq_CD4+_Human1.82678963
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81904047
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79783620
30* IGF1R_20145208_ChIP-Seq_DFB_Human1.75243757
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74492762
32TAF15_26573619_Chip-Seq_HEK293_Human1.73565131
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.71613258
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70067485
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68602401
36ZNF274_21170338_ChIP-Seq_K562_Hela1.65476690
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.59408395
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59181259
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54356204
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53194363
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52982266
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52531633
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.48422092
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.46505346
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42456964
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.41364192
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40792899
48RNF2_27304074_Chip-Seq_NSC_Mouse1.40349493
49AR_21909140_ChIP-Seq_LNCAP_Human1.37486695
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.35661652
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35534072
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35534072
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35339635
54* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35297536
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.32800722
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30482790
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30078443
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29705712
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28298890
60STAT3_18555785_Chip-Seq_ESCs_Mouse1.27501838
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.27346060
62P300_18555785_Chip-Seq_ESCs_Mouse1.25448840
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24884081
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24657109
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23159489
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22966023
67P300_19829295_ChIP-Seq_ESCs_Human1.22922172
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22668559
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.21410684
70P53_22387025_ChIP-Seq_ESCs_Mouse1.20987761
71VDR_22108803_ChIP-Seq_LS180_Human1.20446932
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.19858741
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19310123
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18828602
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17376658
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16980832
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.15627008
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.15339073
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13686524
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12970052
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.11229670
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11042744
83* STAT3_23295773_ChIP-Seq_U87_Human1.10932221
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10926353
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10358006
86CBP_20019798_ChIP-Seq_JUKART_Human1.10285302
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10285302
88ZFX_18555785_Chip-Seq_ESCs_Mouse1.09987867
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.09223047
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08581075
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08414542
92TTF2_22483619_ChIP-Seq_HELA_Human1.08372709
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07891705
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07392660
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.07206868
96IRF1_19129219_ChIP-ChIP_H3396_Human1.07194041
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05982703
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05561138
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03586265
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03382448
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03308511
102ER_23166858_ChIP-Seq_MCF-7_Human1.02287310
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.01502094
104GABP_19822575_ChIP-Seq_HepG2_Human1.00833507
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00747658
106CTCF_18555785_Chip-Seq_ESCs_Mouse1.00739973
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99989453
108MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99887432
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99723779
110TCF4_23295773_ChIP-Seq_U87_Human0.99309131
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99285034
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99130161
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99104861
114MYC_18940864_ChIP-ChIP_HL60_Human0.98443317
115SRF_21415370_ChIP-Seq_HL-1_Mouse0.98208374
116FOXP3_21729870_ChIP-Seq_TREG_Human0.98196321
117* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98044025
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.97900676
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96901248
120SOX9_26525672_Chip-Seq_HEART_Mouse0.95383990
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.94036049
122ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93797503
123SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92677179
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92650770
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92434008
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91903205
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91486733
128DCP1A_22483619_ChIP-Seq_HELA_Human0.91329189
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.90818910
130SMAD4_21799915_ChIP-Seq_A2780_Human0.90805425
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90366928
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90114732
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89840856
134* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88255333
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87919034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.99754301
2MP0010094_abnormal_chromosome_stability3.99050984
3MP0008058_abnormal_DNA_repair3.47989109
4MP0003787_abnormal_imprinting3.47194860
5MP0008057_abnormal_DNA_replication3.44457813
6MP0003111_abnormal_nucleus_morphology3.37145992
7MP0008877_abnormal_DNA_methylation3.24652798
8MP0009697_abnormal_copulation3.15340975
9MP0003693_abnormal_embryo_hatching3.01951199
10MP0000566_synostosis2.78029772
11MP0003121_genomic_imprinting2.74023967
12MP0006292_abnormal_olfactory_placode2.64262723
13MP0000015_abnormal_ear_pigmentation2.54337413
14MP0000569_abnormal_digit_pigmentation2.48389666
15MP0003077_abnormal_cell_cycle2.37058777
16MP0005174_abnormal_tail_pigmentation2.27026698
17MP0005409_darkened_coat_color2.08756739
18MP0003123_paternal_imprinting2.07255393
19MP0002102_abnormal_ear_morphology2.06489133
20MP0008789_abnormal_olfactory_epithelium1.76358922
21MP0010352_gastrointestinal_tract_polyps1.75096325
22MP0002396_abnormal_hematopoietic_system1.70172396
23MP0004957_abnormal_blastocyst_morpholog1.54573758
24MP0003937_abnormal_limbs/digits/tail_de1.51360324
25MP0002249_abnormal_larynx_morphology1.46808884
26MP0002234_abnormal_pharynx_morphology1.45395242
27MP0002163_abnormal_gland_morphology1.44497871
28MP0005499_abnormal_olfactory_system1.41720126
29MP0005394_taste/olfaction_phenotype1.41720126
30MP0003890_abnormal_embryonic-extraembry1.41659158
31MP0005075_abnormal_melanosome_morpholog1.40389339
32MP0009379_abnormal_foot_pigmentation1.38489240
33MP0002210_abnormal_sex_determination1.38050272
34MP0008007_abnormal_cellular_replicative1.37650530
35MP0002095_abnormal_skin_pigmentation1.34972374
36MP0003786_premature_aging1.33901544
37MP0002132_abnormal_respiratory_system1.32286917
38MP0001929_abnormal_gametogenesis1.31720590
39MP0001697_abnormal_embryo_size1.30748923
40MP0003122_maternal_imprinting1.27965428
41MP0002938_white_spotting1.27136822
42MP0010678_abnormal_skin_adnexa1.27127628
43MP0008995_early_reproductive_senescence1.26736824
44MP0002638_abnormal_pupillary_reflex1.24993029
45MP0001299_abnormal_eye_distance/1.23833542
46MP0005395_other_phenotype1.23476676
47MP0003119_abnormal_digestive_system1.21670214
48MP0009780_abnormal_chondrocyte_physiolo1.21661766
49MP0006072_abnormal_retinal_apoptosis1.20485301
50MP0005379_endocrine/exocrine_gland_phen1.18965165
51MP0003984_embryonic_growth_retardation1.18064980
52MP0001119_abnormal_female_reproductive1.15123191
53MP0001984_abnormal_olfaction1.14680911
54MP0002088_abnormal_embryonic_growth/wei1.14604087
55MP0005646_abnormal_pituitary_gland1.14198259
56MP0005551_abnormal_eye_electrophysiolog1.14065389
57MP0005083_abnormal_biliary_tract1.13264089
58MP0005187_abnormal_penis_morphology1.13255690
59MP0003698_abnormal_male_reproductive1.13022315
60MP0000653_abnormal_sex_gland1.12348365
61MP0009703_decreased_birth_body1.11763853
62MP0001145_abnormal_male_reproductive1.08685868
63MP0000631_abnormal_neuroendocrine_gland1.08678101
64MP0003136_yellow_coat_color1.08207794
65MP0002009_preneoplasia1.08066046
66MP0004133_heterotaxia1.05296562
67MP0001986_abnormal_taste_sensitivity1.05106100
68MP0003868_abnormal_feces_composition1.02624712
69MP0003567_abnormal_fetal_cardiomyocyte1.01477879
70MP0003718_maternal_effect1.01286804
71MP0000647_abnormal_sebaceous_gland1.01110667
72MP0004808_abnormal_hematopoietic_stem1.01100364
73MP0005248_abnormal_Harderian_gland1.00331273
74MP0000049_abnormal_middle_ear1.00126752
75MP0010234_abnormal_vibrissa_follicle1.00038794
76MP0001486_abnormal_startle_reflex0.99506393
77MP0005253_abnormal_eye_physiology0.99351721
78MP0001905_abnormal_dopamine_level0.98801612
79MP0008932_abnormal_embryonic_tissue0.98746910
80MP0001529_abnormal_vocalization0.98671115
81MP0000427_abnormal_hair_cycle0.98136100
82MP0006035_abnormal_mitochondrial_morpho0.97303508
83MP0003938_abnormal_ear_development0.96725915
84MP0000490_abnormal_crypts_of0.96565735
85MP0003699_abnormal_female_reproductive0.96341322
86MP0010030_abnormal_orbit_morphology0.94938996
87MP0002177_abnormal_outer_ear0.94687858
88MP0005220_abnormal_exocrine_pancreas0.94082336
89MP0001293_anophthalmia0.92845716
90MP0004043_abnormal_pH_regulation0.92471560
91MP0000350_abnormal_cell_proliferation0.89552733
92MP0001286_abnormal_eye_development0.89210201
93MP0002085_abnormal_embryonic_tissue0.88951695
94MP0003315_abnormal_perineum_morphology0.88936137
95MP0005408_hypopigmentation0.87363115
96MP0003941_abnormal_skin_development0.86138692
97MP0002233_abnormal_nose_morphology0.85244582
98MP0000432_abnormal_head_morphology0.85081110
99MP0000026_abnormal_inner_ear0.84447837
100MP0002080_prenatal_lethality0.84302655
101MP0001661_extended_life_span0.83564702
102MP0009250_abnormal_appendicular_skeleto0.82748428
103MP0002160_abnormal_reproductive_system0.82231186
104MP0005389_reproductive_system_phenotype0.80635007
105MP0003763_abnormal_thymus_physiology0.80628387
106MP0004134_abnormal_chest_morphology0.79948573
107MP0005171_absent_coat_pigmentation0.79582960
108MP0002697_abnormal_eye_size0.79541228
109MP0001485_abnormal_pinna_reflex0.79452420
110MP0000428_abnormal_craniofacial_morphol0.78770419
111MP0005367_renal/urinary_system_phenotyp0.78675485
112MP0000516_abnormal_urinary_system0.78675485
113MP0002114_abnormal_axial_skeleton0.78354936
114MP0000358_abnormal_cell_content/0.78174090
115MP0005380_embryogenesis_phenotype0.76190525
116MP0001672_abnormal_embryogenesis/_devel0.76190525
117MP0003861_abnormal_nervous_system0.75543771
118MP0003935_abnormal_craniofacial_develop0.74642638
119MP0001963_abnormal_hearing_physiology0.74157361
120MP0001919_abnormal_reproductive_system0.73641149
121MP0002092_abnormal_eye_morphology0.73624384
122MP0003755_abnormal_palate_morphology0.73048331
123MP0002111_abnormal_tail_morphology0.72955058
124MP0009672_abnormal_birth_weight0.72759319
125MP0003943_abnormal_hepatobiliary_system0.72605576
126MP0003252_abnormal_bile_duct0.72371183
127MP0002161_abnormal_fertility/fecundity0.72264415
128MP0002116_abnormal_craniofacial_bone0.72118449
129MP0001186_pigmentation_phenotype0.71705978
130MP0004147_increased_porphyrin_level0.71438537
131MP0001730_embryonic_growth_arrest0.70900080
132MP0010307_abnormal_tumor_latency0.70296448
133MP0005391_vision/eye_phenotype0.70039584
134MP0002751_abnormal_autonomic_nervous0.69892440
135MP0000383_abnormal_hair_follicle0.69576070
136MP0001324_abnormal_eye_pigmentation0.69412288
137MP0004742_abnormal_vestibular_system0.69328515
138MP0005645_abnormal_hypothalamus_physiol0.68810494
139MP0002084_abnormal_developmental_patter0.68095637
140MP0004197_abnormal_fetal_growth/weight/0.67506114

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.52956010
2Chromsome breakage (HP:0040012)5.23514747
3Abnormality of chromosome stability (HP:0003220)3.63924905
4Abnormality of the preputium (HP:0100587)3.60648476
5Median cleft lip (HP:0000161)3.51513605
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.40238954
7Volvulus (HP:0002580)3.32114079
8Meckel diverticulum (HP:0002245)3.28458289
9Colon cancer (HP:0003003)3.24290765
10Duplicated collecting system (HP:0000081)3.22080618
11Abnormality of the ileum (HP:0001549)3.16617059
12Abnormality of the renal collecting system (HP:0004742)3.06175654
13Prostate neoplasm (HP:0100787)2.95198038
14Medulloblastoma (HP:0002885)2.91284231
15Tubulointerstitial nephritis (HP:0001970)2.86483264
16Supernumerary spleens (HP:0009799)2.83452358
17Nephroblastoma (Wilms tumor) (HP:0002667)2.83002767
18Papillary thyroid carcinoma (HP:0002895)2.80556559
19Ectopic kidney (HP:0000086)2.74039839
20Abnormality of the carotid arteries (HP:0005344)2.66823630
21Small intestinal stenosis (HP:0012848)2.66109178
22Duodenal stenosis (HP:0100867)2.66109178
23Rhinitis (HP:0012384)2.65677760
24Embryonal renal neoplasm (HP:0011794)2.63894789
25Acute lymphatic leukemia (HP:0006721)2.59697214
26Septo-optic dysplasia (HP:0100842)2.57180702
27Clubbing of toes (HP:0100760)2.57133631
28Abnormal respiratory motile cilium physiology (HP:0012261)2.56918176
29Impulsivity (HP:0100710)2.54691734
30Abnormality of DNA repair (HP:0003254)2.52533584
31Abnormal ciliary motility (HP:0012262)2.52230521
32Neoplasm of the oral cavity (HP:0100649)2.51772702
33Congenital primary aphakia (HP:0007707)2.47775849
34Sloping forehead (HP:0000340)2.46928544
35Bifid tongue (HP:0010297)2.44176456
36Anal stenosis (HP:0002025)2.35239964
37Renal cortical cysts (HP:0000803)2.35060677
38Abnormality of the duodenum (HP:0002246)2.31840485
39Poor coordination (HP:0002370)2.28738470
40Pancreatic fibrosis (HP:0100732)2.26957246
41Birth length less than 3rd percentile (HP:0003561)2.25526008
42Microvesicular hepatic steatosis (HP:0001414)2.25102573
43Abnormality of the fingertips (HP:0001211)2.22943499
44Nephrogenic diabetes insipidus (HP:0009806)2.22109083
45Abnormality of the labia minora (HP:0012880)2.21554583
46Genital tract atresia (HP:0001827)2.21403783
47Gait imbalance (HP:0002141)2.21029114
48Abnormal lung lobation (HP:0002101)2.20482760
49Myelodysplasia (HP:0002863)2.18618440
50Neoplasm of the adrenal cortex (HP:0100641)2.18265281
51Thyroid carcinoma (HP:0002890)2.17802948
52Rhabdomyosarcoma (HP:0002859)2.16434808
53Pancreatic cysts (HP:0001737)2.16107496
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.13641568
55Absent/shortened dynein arms (HP:0200106)2.13641568
56Nephronophthisis (HP:0000090)2.12981208
57Sex reversal (HP:0012245)2.10776423
58Abnormal sex determination (HP:0012244)2.10776423
59Fair hair (HP:0002286)2.10501344
60Absent septum pellucidum (HP:0001331)2.10354091
61Abnormal respiratory motile cilium morphology (HP:0005938)2.10102263
62Abnormal hair whorl (HP:0010721)2.09334426
63Anal atresia (HP:0002023)2.08963412
64Increased hepatocellular lipid droplets (HP:0006565)2.07482550
65Oligodactyly (hands) (HP:0001180)2.07115456
66Chronic bronchitis (HP:0004469)2.06754052
67True hermaphroditism (HP:0010459)2.06052348
68Bone marrow hypocellularity (HP:0005528)2.04888903
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.04716318
70Protruding tongue (HP:0010808)2.03828138
71Short thumb (HP:0009778)2.03302359
72Abnormality of the septum pellucidum (HP:0007375)2.02551187
73Vaginal atresia (HP:0000148)2.01723405
74Abnormal pancreas size (HP:0012094)2.01466822
75Abnormality of midbrain morphology (HP:0002418)2.01463904
76Molar tooth sign on MRI (HP:0002419)2.01463904
77Tented upper lip vermilion (HP:0010804)2.01221828
78Intestinal atresia (HP:0011100)2.01203300
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.00498246
80Abnormality of the renal medulla (HP:0100957)1.99971215
81Postaxial hand polydactyly (HP:0001162)1.99536107
82Severe visual impairment (HP:0001141)1.99082803
83Congenital stationary night blindness (HP:0007642)1.99038361
84Postaxial foot polydactyly (HP:0001830)1.97877942
85Hyperglycinemia (HP:0002154)1.96889125
86Increased nuchal translucency (HP:0010880)1.96307847
87Methylmalonic acidemia (HP:0002912)1.95805292
88Male pseudohermaphroditism (HP:0000037)1.93047092
89Absent speech (HP:0001344)1.90910449
90Preaxial hand polydactyly (HP:0001177)1.90064241
91Absent thumb (HP:0009777)1.89994428
92Short tibia (HP:0005736)1.89361006
93Lipid accumulation in hepatocytes (HP:0006561)1.89002829
94Abnormality of the renal cortex (HP:0011035)1.88319916
95Chorioretinal coloboma (HP:0000567)1.86205986
96Triphalangeal thumb (HP:0001199)1.86061609
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.85371305
98Abnormality of the intervertebral disk (HP:0005108)1.84466143
99Hepatoblastoma (HP:0002884)1.81980860
100Lip pit (HP:0100267)1.81359359
101Choanal atresia (HP:0000453)1.80828769
102Facial hemangioma (HP:0000329)1.80513382
103Duplication of thumb phalanx (HP:0009942)1.80386813
104Gonadotropin excess (HP:0000837)1.80163535
105Small hand (HP:0200055)1.79725002
106Abnormality of the prostate (HP:0008775)1.78824827
107Optic nerve hypoplasia (HP:0000609)1.78032999
108Absent radius (HP:0003974)1.77532258
109Cystic liver disease (HP:0006706)1.76072577
110Generalized hypopigmentation of hair (HP:0011358)1.75338646
111Oligohydramnios (HP:0001562)1.75199615
112Chronic hepatic failure (HP:0100626)1.74691195
113Supernumerary ribs (HP:0005815)1.74508709
114Horseshoe kidney (HP:0000085)1.74415406
115Patellar aplasia (HP:0006443)1.73383898
116Absent forearm bone (HP:0003953)1.72825465
117Aplasia involving forearm bones (HP:0009822)1.72825465
118Asplenia (HP:0001746)1.72703545
119Prominent metopic ridge (HP:0005487)1.71871016
120Embryonal neoplasm (HP:0002898)1.71498378
121Occipital encephalocele (HP:0002085)1.71496803
122Acute myeloid leukemia (HP:0004808)1.70629880
123Gastroesophageal reflux (HP:0002020)1.69951995
124Supernumerary bones of the axial skeleton (HP:0009144)1.68696536
125Hypoglycemic coma (HP:0001325)1.68353874
126Glioma (HP:0009733)1.68051166
127Renal agenesis (HP:0000104)1.67517065
128Aganglionic megacolon (HP:0002251)1.67018811
129Febrile seizures (HP:0002373)1.66343209
130Limb hypertonia (HP:0002509)1.65687036
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65610875
132Sensory axonal neuropathy (HP:0003390)1.65400597
133Astigmatism (HP:0000483)1.65004442
134Facial cleft (HP:0002006)1.64738390
135Attenuation of retinal blood vessels (HP:0007843)1.63383973
136Abnormality of the metopic suture (HP:0005556)1.63249167
137Medial flaring of the eyebrow (HP:0010747)1.62866161
138Abnormality of the astrocytes (HP:0100707)1.62749118
139Astrocytoma (HP:0009592)1.62749118
140Cleft eyelid (HP:0000625)1.61773959
141Abnormality of the antihelix (HP:0009738)1.61755232
142Renovascular hypertension (HP:0100817)1.61072395
143Abnormality of the parietal bone (HP:0002696)1.60365298
144Abnormal respiratory epithelium morphology (HP:0012253)1.60083481
145Deep philtrum (HP:0002002)1.60053022
146Arteriovenous malformation (HP:0100026)1.59956129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.53610012
2MKNK23.22651107
3NEK12.59942071
4CASK2.53513364
5SRPK12.50773226
6MKNK12.42656072
7ZAK2.35494966
8PBK2.24524667
9CDK82.05544413
10TRIM281.98831979
11CHEK21.95524314
12TTK1.95354917
13ATR1.91526396
14CDK121.91001252
15SCYL21.84245558
16EIF2AK31.82881129
17PLK31.76690684
18TAF11.75885005
19NEK61.74358539
20WEE11.73543444
21FRK1.71457806
22VRK11.64478644
23CDK91.60959821
24CAMK1G1.59935246
25NEK21.59919931
26STK38L1.57735369
27STK41.56734961
28MST41.54418452
29VRK21.53028384
30ACVR1B1.52552858
31PLK41.50375765
32NLK1.50238569
33NUAK11.49049758
34LATS11.47664375
35EIF2AK11.45843324
36PLK11.45131653
37CLK11.44631638
38BRD41.41716723
39EIF2AK21.41556812
40CDK41.39780577
41MAPK131.36713026
42CDK71.36164852
43MAP4K21.29049975
44CAMK1D1.28877784
45MAP2K71.28339115
46ATM1.25597649
47MUSK1.24976986
48STK31.24169285
49BUB11.23955957
50MAP3K41.23816805
51ERBB31.23690583
52TXK1.17592445
53PASK1.15159779
54CDK31.11157362
55AURKB1.09826640
56NEK91.09693344
57YES11.08474732
58CHEK11.06580471
59PNCK1.04263144
60BMPR1B1.00613368
61TNIK0.98684851
62DYRK30.96058426
63GRK10.94153203
64BRSK20.93139854
65TLK10.89180196
66CSNK1A1L0.87947688
67BLK0.86066161
68STK380.85444009
69MELK0.84759549
70CSNK1G30.84483097
71CDK10.84315662
72STK160.84019818
73FGFR20.83025399
74CDK20.79688796
75CSNK1G10.79515109
76DMPK0.78970083
77SGK20.78531295
78STK390.78462650
79TNK20.77763470
80CAMKK20.73636068
81NTRK30.73119401
82BMPR20.72944782
83PIM10.72017406
84ADRBK20.71439364
85AKT30.69786645
86MAPK140.68896340
87RPS6KA50.68860385
88CCNB10.67762015
89TRPM70.66980348
90STK240.64270184
91TSSK60.64021546
92EPHA40.63740411
93TEC0.63729865
94DYRK20.63399874
95SGK30.63338584
96CSNK1D0.62796140
97ERBB40.62119218
98CSNK1G20.61290440
99PLK20.60721749
100DYRK1A0.58967480
101CSNK1E0.58452353
102GSK3B0.57461591
103TAOK30.56832077
104PIK3CA0.56524822
105MAP3K60.56162999
106RPS6KA40.54834730
107OXSR10.54488352
108PKN10.54487369
109PRKDC0.53499910
110SIK30.51916823
111RPS6KB10.51136052
112MAP3K130.50399298
113WNK30.48682042
114CSNK2A20.48203539
115MAP3K70.47782336
116BCR0.46212153
117CDK190.45916972
118RPS6KB20.45652845
119PRPF4B0.45335258
120PRKACB0.44463920
121INSRR0.43360387
122KSR10.42590950
123AURKA0.41498831
124STK100.41390288
125FLT30.41278359
126MAPK100.40656527
127FGFR10.40623398
128BRSK10.37770338
129CSNK2A10.36066079
130PKN20.30807382

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.33667157
2Homologous recombination_Homo sapiens_hsa034404.21711533
3Non-homologous end-joining_Homo sapiens_hsa034503.83700024
4* Mismatch repair_Homo sapiens_hsa034303.61696191
5DNA replication_Homo sapiens_hsa030303.59223379
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20243363
7Basal transcription factors_Homo sapiens_hsa030222.94344252
8Cell cycle_Homo sapiens_hsa041102.85588821
9Nucleotide excision repair_Homo sapiens_hsa034202.45700807
10Spliceosome_Homo sapiens_hsa030402.45460087
11RNA degradation_Homo sapiens_hsa030182.41779855
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39285688
13Base excision repair_Homo sapiens_hsa034102.26842699
14RNA polymerase_Homo sapiens_hsa030202.25155617
15mRNA surveillance pathway_Homo sapiens_hsa030152.19495155
16RNA transport_Homo sapiens_hsa030132.18984462
17Propanoate metabolism_Homo sapiens_hsa006402.03542324
18Phototransduction_Homo sapiens_hsa047441.94744282
19One carbon pool by folate_Homo sapiens_hsa006701.89649779
20Systemic lupus erythematosus_Homo sapiens_hsa053221.78177467
21Protein export_Homo sapiens_hsa030601.76973843
22Nicotine addiction_Homo sapiens_hsa050331.69916451
23Pyrimidine metabolism_Homo sapiens_hsa002401.66979819
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66878237
25Primary immunodeficiency_Homo sapiens_hsa053401.60054835
26Caffeine metabolism_Homo sapiens_hsa002321.55356371
27Proteasome_Homo sapiens_hsa030501.45501209
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.40215389
29Purine metabolism_Homo sapiens_hsa002301.34906707
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33272014
31Basal cell carcinoma_Homo sapiens_hsa052171.32965456
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26582245
33Alcoholism_Homo sapiens_hsa050341.22850224
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21471513
35Selenocompound metabolism_Homo sapiens_hsa004501.19661608
36p53 signaling pathway_Homo sapiens_hsa041151.17349324
37Ribosome_Homo sapiens_hsa030101.15996170
38Huntingtons disease_Homo sapiens_hsa050161.10560489
39Wnt signaling pathway_Homo sapiens_hsa043101.09215678
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09105236
41Fatty acid elongation_Homo sapiens_hsa000621.06866656
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05800926
43Lysine degradation_Homo sapiens_hsa003101.03544157
44Pyruvate metabolism_Homo sapiens_hsa006201.02937255
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02405704
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97312217
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95675348
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93655085
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88863968
50MicroRNAs in cancer_Homo sapiens_hsa052060.87845825
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86427221
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84806967
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83282105
54Butanoate metabolism_Homo sapiens_hsa006500.81154356
55Peroxisome_Homo sapiens_hsa041460.80684204
56Thyroid cancer_Homo sapiens_hsa052160.78128725
57Herpes simplex infection_Homo sapiens_hsa051680.77531169
58Oocyte meiosis_Homo sapiens_hsa041140.77411356
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77029622
60Serotonergic synapse_Homo sapiens_hsa047260.76866839
61beta-Alanine metabolism_Homo sapiens_hsa004100.76833822
62Adherens junction_Homo sapiens_hsa045200.75568132
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74854424
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74549130
65Oxidative phosphorylation_Homo sapiens_hsa001900.74469220
66Viral carcinogenesis_Homo sapiens_hsa052030.73842695
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73019585
68Fatty acid degradation_Homo sapiens_hsa000710.71758855
69Steroid biosynthesis_Homo sapiens_hsa001000.71460315
70Parkinsons disease_Homo sapiens_hsa050120.68909786
71Taste transduction_Homo sapiens_hsa047420.68193294
72Circadian rhythm_Homo sapiens_hsa047100.66321554
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65529630
74Folate biosynthesis_Homo sapiens_hsa007900.65441329
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65211553
76Fatty acid metabolism_Homo sapiens_hsa012120.64531965
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63661499
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63314376
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62980509
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61761819
81TGF-beta signaling pathway_Homo sapiens_hsa043500.61714398
82Glutathione metabolism_Homo sapiens_hsa004800.59931540
83Sphingolipid metabolism_Homo sapiens_hsa006000.59510578
84HTLV-I infection_Homo sapiens_hsa051660.59098555
85Chemical carcinogenesis_Homo sapiens_hsa052040.59016299
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58687553
87Regulation of autophagy_Homo sapiens_hsa041400.58401312
88Morphine addiction_Homo sapiens_hsa050320.58276675
89Epstein-Barr virus infection_Homo sapiens_hsa051690.57025867
90Cocaine addiction_Homo sapiens_hsa050300.56467110
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.55815077
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.52348950
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52292093
94Metabolic pathways_Homo sapiens_hsa011000.51423897
95Notch signaling pathway_Homo sapiens_hsa043300.50592803
96Retinol metabolism_Homo sapiens_hsa008300.50301162
97Olfactory transduction_Homo sapiens_hsa047400.49121779
98Long-term depression_Homo sapiens_hsa047300.48022481
99Calcium signaling pathway_Homo sapiens_hsa040200.47748943
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47135279
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46190172
102Tryptophan metabolism_Homo sapiens_hsa003800.45865815
103Hedgehog signaling pathway_Homo sapiens_hsa043400.45256537
104* Colorectal cancer_Homo sapiens_hsa052100.44043205
105Measles_Homo sapiens_hsa051620.43754437
106Inositol phosphate metabolism_Homo sapiens_hsa005620.43584344
107Carbon metabolism_Homo sapiens_hsa012000.43244477
108Amphetamine addiction_Homo sapiens_hsa050310.43162608
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.42889689
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.42590812
111Melanoma_Homo sapiens_hsa052180.41560440
112Pancreatic cancer_Homo sapiens_hsa052120.40977287
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39944355
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38949222
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37892569
116Glutamatergic synapse_Homo sapiens_hsa047240.37853456
117Ether lipid metabolism_Homo sapiens_hsa005650.37711799
118Prostate cancer_Homo sapiens_hsa052150.37352380
119* Pathways in cancer_Homo sapiens_hsa052000.36482806
120Tight junction_Homo sapiens_hsa045300.35858537
121Sulfur metabolism_Homo sapiens_hsa009200.35741452
122Hippo signaling pathway_Homo sapiens_hsa043900.35607382
123ABC transporters_Homo sapiens_hsa020100.31958295
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31661426
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31222825
126Axon guidance_Homo sapiens_hsa043600.30884438
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28423358
128Tyrosine metabolism_Homo sapiens_hsa003500.27658857
129FoxO signaling pathway_Homo sapiens_hsa040680.25377421
130Hematopoietic cell lineage_Homo sapiens_hsa046400.25016538
131Ovarian steroidogenesis_Homo sapiens_hsa049130.24926672
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24660218
133N-Glycan biosynthesis_Homo sapiens_hsa005100.24108775
134Alzheimers disease_Homo sapiens_hsa050100.23936924
135Starch and sucrose metabolism_Homo sapiens_hsa005000.23404669
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23070120
137Circadian entrainment_Homo sapiens_hsa047130.22077588
138Biosynthesis of amino acids_Homo sapiens_hsa012300.21736941
139Choline metabolism in cancer_Homo sapiens_hsa052310.21291413
140Vitamin B6 metabolism_Homo sapiens_hsa007500.21048699
141cAMP signaling pathway_Homo sapiens_hsa040240.19873992
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19566042
143Small cell lung cancer_Homo sapiens_hsa052220.18871570
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.18542034
145Hepatitis B_Homo sapiens_hsa051610.18146513
146Ras signaling pathway_Homo sapiens_hsa040140.17945183
147T cell receptor signaling pathway_Homo sapiens_hsa046600.15479620
148Dopaminergic synapse_Homo sapiens_hsa047280.13861862
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13713623
150MAPK signaling pathway_Homo sapiens_hsa040100.11851534
151Cholinergic synapse_Homo sapiens_hsa047250.11821429
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11165611
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.11052431

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