MSH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.70835814
2DNA methylation involved in gamete generation (GO:0043046)4.80047423
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72778505
4male meiosis I (GO:0007141)4.68086505
5chromosome organization involved in meiosis (GO:0070192)4.47492941
6positive regulation of gamma-delta T cell activation (GO:0046645)4.00512106
7male meiosis (GO:0007140)4.00336626
8centriole replication (GO:0007099)3.81283905
9DNA replication checkpoint (GO:0000076)3.72799236
10fucose catabolic process (GO:0019317)3.70000232
11L-fucose metabolic process (GO:0042354)3.70000232
12L-fucose catabolic process (GO:0042355)3.70000232
13meiosis I (GO:0007127)3.67885847
14behavioral response to nicotine (GO:0035095)3.65434495
15* reciprocal meiotic recombination (GO:0007131)3.64814148
16* reciprocal DNA recombination (GO:0035825)3.64814148
17positive regulation of B cell differentiation (GO:0045579)3.52970698
18DNA synthesis involved in DNA repair (GO:0000731)3.50541962
19* meiotic chromosome segregation (GO:0045132)3.47351987
20kinetochore organization (GO:0051383)3.45915244
21regulation of RIG-I signaling pathway (GO:0039535)3.45418532
22response to pheromone (GO:0019236)3.44891538
23meiotic nuclear division (GO:0007126)3.41749792
24histone H3-K9 methylation (GO:0051567)3.40329064
25recombinational repair (GO:0000725)3.38364289
26double-strand break repair via homologous recombination (GO:0000724)3.37887347
27synaptonemal complex assembly (GO:0007130)3.35372209
28resolution of meiotic recombination intermediates (GO:0000712)3.27323389
29superoxide anion generation (GO:0042554)3.26902509
30DNA methylation (GO:0006306)3.26281971
31DNA alkylation (GO:0006305)3.26281971
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25360194
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.25360194
34modulation by symbiont of host immune response (GO:0052553)3.25360194
35positive regulation by symbiont of host defense response (GO:0052509)3.25360194
36modulation by symbiont of host defense response (GO:0052031)3.25360194
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25360194
38sister chromatid cohesion (GO:0007062)3.19914399
39kinetochore assembly (GO:0051382)3.17552680
40telomere maintenance via semi-conservative replication (GO:0032201)3.09868014
41regulation of B cell differentiation (GO:0045577)3.07061024
42gene silencing by RNA (GO:0031047)3.03848575
43telomere maintenance via recombination (GO:0000722)3.01974185
44response to peptidoglycan (GO:0032494)2.97039770
45* meiotic cell cycle process (GO:1903046)2.97009829
46DNA strand renaturation (GO:0000733)2.95200276
47negative regulation of DNA-dependent DNA replication (GO:2000104)2.93801668
48microtubule depolymerization (GO:0007019)2.93693867
49regulation of histone H3-K9 methylation (GO:0051570)2.93532808
50poly(A)+ mRNA export from nucleus (GO:0016973)2.91431601
51regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.91052733
52DNA methylation or demethylation (GO:0044728)2.90362791
53dendritic cell chemotaxis (GO:0002407)2.89842387
54cilium or flagellum-dependent cell motility (GO:0001539)2.88893191
55synaptonemal complex organization (GO:0070193)2.88875751
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88646065
57DNA replication initiation (GO:0006270)2.88343729
58translesion synthesis (GO:0019985)2.88129887
59centriole assembly (GO:0098534)2.86284102
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85333775
61DNA modification (GO:0006304)2.84736331
62tryptophan catabolic process (GO:0006569)2.84588957
63indole-containing compound catabolic process (GO:0042436)2.84588957
64indolalkylamine catabolic process (GO:0046218)2.84588957
65DNA replication-dependent nucleosome assembly (GO:0006335)2.84584167
66DNA replication-dependent nucleosome organization (GO:0034723)2.84584167
67histone H2A monoubiquitination (GO:0035518)2.84146721
68mitotic recombination (GO:0006312)2.82503003
69positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80462066
70G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80097711
71somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78396242
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.78396242
73negative regulation of telomere maintenance (GO:0032205)2.78109285
74tRNA modification (GO:0006400)2.77974098
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77430719
76oxidative demethylation (GO:0070989)2.77063988
77interkinetic nuclear migration (GO:0022027)2.75909749
78regulation of B cell receptor signaling pathway (GO:0050855)2.75545660
79rRNA catabolic process (GO:0016075)2.75249260
80protein import into peroxisome matrix (GO:0016558)2.75246189
81heparin biosynthetic process (GO:0030210)2.74243008
82heparin metabolic process (GO:0030202)2.74243008
83intra-S DNA damage checkpoint (GO:0031573)2.74229512
84regulation of centrosome cycle (GO:0046605)2.71844467
85indolalkylamine metabolic process (GO:0006586)2.70425520
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.70097205
87NADH dehydrogenase complex assembly (GO:0010257)2.70097205
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70097205
89* DNA recombination (GO:0006310)2.69835627
90regulation of DNA endoreduplication (GO:0032875)2.68988111
91piRNA metabolic process (GO:0034587)2.67256432
92response to host immune response (GO:0052572)2.66797322
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66797322
94tryptophan metabolic process (GO:0006568)2.66349673
95regulation of meiosis I (GO:0060631)2.64750728
96detection of other organism (GO:0098543)2.63854450
97histone H3-K9 modification (GO:0061647)2.62964235
98megakaryocyte development (GO:0035855)2.61298539
99metaphase plate congression (GO:0051310)2.61153900
100neutrophil activation involved in immune response (GO:0002283)2.60858477
101immunoglobulin mediated immune response (GO:0016064)2.60790547
102nucleobase biosynthetic process (GO:0046112)2.60680557
103telomere maintenance via telomere lengthening (GO:0010833)2.59816281
104dendritic cell migration (GO:0036336)2.56884386
105positive regulation of natural killer cell differentiation (GO:0032825)2.56768995
106mitotic sister chromatid segregation (GO:0000070)2.56021737
107regulation of centrosome duplication (GO:0010824)2.55588146
108production of molecular mediator involved in inflammatory response (GO:0002532)2.55330675
109kynurenine metabolic process (GO:0070189)2.55109089
110regulation of gamma-delta T cell activation (GO:0046643)2.54649165
111sister chromatid segregation (GO:0000819)2.54607566
112centrosome organization (GO:0051297)2.54543931
113telomere maintenance (GO:0000723)2.54531511
114axoneme assembly (GO:0035082)2.53731063
115motile cilium assembly (GO:0044458)2.53185931
116regulation of histone H3-K4 methylation (GO:0051569)2.52921462
117detection of light stimulus involved in sensory perception (GO:0050962)2.52611188
118detection of light stimulus involved in visual perception (GO:0050908)2.52611188
119DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.52448424
120NIK/NF-kappaB signaling (GO:0038061)2.52216132
121protein complex biogenesis (GO:0070271)2.52124218
122histamine secretion (GO:0001821)2.52053860
123pseudouridine synthesis (GO:0001522)2.51953148
124myeloid dendritic cell activation (GO:0001773)2.51886387
125DNA-dependent DNA replication (GO:0006261)2.51674345
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.50896141
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50198208
128interferon-gamma production (GO:0032609)2.50117679
129telomere organization (GO:0032200)2.49888485
130misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.49822803
131epithelial cilium movement (GO:0003351)2.49677057
132base-excision repair, AP site formation (GO:0006285)2.49520160
133replication fork processing (GO:0031297)2.48935369
134detection of molecule of bacterial origin (GO:0032490)2.48896214
135negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.48870147
136necroptotic process (GO:0070266)2.47761336
137preassembly of GPI anchor in ER membrane (GO:0016254)2.46368170
138definitive hemopoiesis (GO:0060216)2.45659635
139mitochondrial respiratory chain complex assembly (GO:0033108)2.44571508
140histone H2A acetylation (GO:0043968)2.43792416
141regulation of centriole replication (GO:0046599)2.43708270
142maturation of 5.8S rRNA (GO:0000460)2.42413543
143postreplication repair (GO:0006301)2.42364296
144cellular response to exogenous dsRNA (GO:0071360)2.42133879
145B cell receptor signaling pathway (GO:0050853)2.41481990
146response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41214203
147response to host (GO:0075136)2.41214203
148response to host defenses (GO:0052200)2.41214203
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.40087875
150DNA strand elongation (GO:0022616)2.39767233
151CENP-A containing nucleosome assembly (GO:0034080)2.39747656
152detection of bacterium (GO:0016045)2.39314557
153I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.37450234
154DNA strand elongation involved in DNA replication (GO:0006271)2.37032465
155mitotic sister chromatid cohesion (GO:0007064)2.36833075
156regulation of defense response to virus by host (GO:0050691)2.36633591
157positive regulation of defense response to virus by host (GO:0002230)2.36121488
158regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.35766589
159neutrophil activation (GO:0042119)2.35343128
160macrophage activation involved in immune response (GO:0002281)2.35084339
161regulation of T cell mediated cytotoxicity (GO:0001914)2.34860824
162histamine transport (GO:0051608)2.33658820
163regulation of activation of Janus kinase activity (GO:0010533)2.33657813
164positive regulation of DNA-dependent DNA replication (GO:2000105)2.33574475
165mitotic metaphase plate congression (GO:0007080)2.32687096
166DNA deamination (GO:0045006)2.32017231
167modulation by virus of host process (GO:0019054)2.31337050
168DNA integration (GO:0015074)2.31088374
169regulation of helicase activity (GO:0051095)2.30974420
170chromatin remodeling at centromere (GO:0031055)2.30808169
171establishment of chromosome localization (GO:0051303)2.28965119
172protein K6-linked ubiquitination (GO:0085020)2.27493355
173T cell lineage commitment (GO:0002360)2.26241789
174purine ribonucleotide transport (GO:0015868)2.25172495
175positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.24730947
176positive regulation of Cdc42 GTPase activity (GO:0043089)2.23196370
177DNA ligation (GO:0006266)2.22052090
178positive regulation of interferon-alpha production (GO:0032727)2.21440735
179detection of biotic stimulus (GO:0009595)2.21312536
180programmed necrotic cell death (GO:0097300)2.20580777
181metallo-sulfur cluster assembly (GO:0031163)2.19786135
182iron-sulfur cluster assembly (GO:0016226)2.19786135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93894739
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.03947826
3ZNF274_21170338_ChIP-Seq_K562_Hela3.71751040
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.49958889
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43753625
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22241986
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.03044323
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.99556536
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76693801
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73873090
11VDR_22108803_ChIP-Seq_LS180_Human2.70834349
12SCL_19346495_ChIP-Seq_HPC-7_Human2.70723580
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68979151
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61482421
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.57058406
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56496113
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39845686
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27192981
19* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22510429
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22421120
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.22009239
22GATA1_22025678_ChIP-Seq_K562_Human2.13292059
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10040902
24MYC_18940864_ChIP-ChIP_HL60_Human2.04127157
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03655427
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00256466
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.98689602
28KDM5A_27292631_Chip-Seq_BREAST_Human1.96061562
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95249256
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95136125
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.87961229
32SPI1_23547873_ChIP-Seq_NB4_Human1.87934864
33EZH2_22144423_ChIP-Seq_EOC_Human1.84815570
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84743836
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84533134
36* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83207868
37IRF1_19129219_ChIP-ChIP_H3396_Human1.82945705
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82107388
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81317615
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81052757
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78243019
42EWS_26573619_Chip-Seq_HEK293_Human1.77829373
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77498619
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.76091613
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.76041737
46* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74820441
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74765977
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73034440
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72291975
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67826209
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64280314
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.62429023
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59425155
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59245690
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57372866
56* E2F1_21310950_ChIP-Seq_MCF-7_Human1.56233271
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.54747494
58GABP_19822575_ChIP-Seq_HepG2_Human1.54107426
59ERA_21632823_ChIP-Seq_H3396_Human1.53815361
60TTF2_22483619_ChIP-Seq_HELA_Human1.52761638
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51972851
62TP53_22573176_ChIP-Seq_HFKS_Human1.49821073
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48786023
64XRN2_22483619_ChIP-Seq_HELA_Human1.48250362
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48018297
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47260496
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45300643
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44902612
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41601698
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41275178
71MYB_26560356_Chip-Seq_TH2_Human1.41135661
72MYB_26560356_Chip-Seq_TH1_Human1.39891905
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39740380
74FUS_26573619_Chip-Seq_HEK293_Human1.35558348
75VDR_23849224_ChIP-Seq_CD4+_Human1.35299595
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35291993
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34085379
78FOXP3_21729870_ChIP-Seq_TREG_Human1.32501244
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32194157
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30216293
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.29901364
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.29037180
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27306651
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26985132
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.25927432
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.25414099
87* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25333197
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25105501
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24829097
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.24793744
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24130633
92E2F1_20622854_ChIP-Seq_HELA_Human1.23158236
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.23064246
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.22102449
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21176429
96ER_23166858_ChIP-Seq_MCF-7_Human1.20987093
97DCP1A_22483619_ChIP-Seq_HELA_Human1.19226855
98ELK1_19687146_ChIP-ChIP_HELA_Human1.18423750
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.16786717
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16350589
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15496539
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15076267
103PHF8_20622854_ChIP-Seq_HELA_Human1.14942106
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14321304
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13718144
106HOXB7_26014856_ChIP-Seq_BT474_Human1.13468178
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12677971
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12085195
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.12085195
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.11869787
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11550921
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11193431
113CIITA_25753668_ChIP-Seq_RAJI_Human1.10077136
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09436029
115VDR_24763502_ChIP-Seq_THP-1_Human1.08990053
116KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08853890
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08293973
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08025052
119TAF2_19829295_ChIP-Seq_ESCs_Human1.07548883
120AR_21572438_ChIP-Seq_LNCaP_Human1.07310226
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06231661
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06064741
123P53_22387025_ChIP-Seq_ESCs_Mouse1.05782641
124OCT4_18555785_Chip-Seq_ESCs_Mouse1.05777190
125BCL6_27268052_Chip-Seq_Bcells_Human1.04117752
126ZFX_18555785_Chip-Seq_ESCs_Mouse1.04064725
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03202651
128PU1_27457419_Chip-Seq_LIVER_Mouse1.03154205
129E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02587209
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02482308
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02314620
132NCOR_22424771_ChIP-Seq_293T_Human1.02091348
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02047577
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01226437
135PU_27001747_Chip-Seq_BMDM_Mouse1.01060293
136RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00992692
137GABP_17652178_ChIP-ChIP_JURKAT_Human1.00857529
138* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00711587
139P68_20966046_ChIP-Seq_HELA_Human1.00657916
140* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00349943
141ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00269765
142POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00063674
143* P53_21459846_ChIP-Seq_SAOS-2_Human0.99587065
144RNF2_27304074_Chip-Seq_NSC_Mouse0.99459673
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.99403033
146SPI1_23127762_ChIP-Seq_K562_Human0.98970700
147NANOG_20526341_ChIP-Seq_ESCs_Human0.98784599
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98519732
149ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97902261
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.97564923
151THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97018385
152KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96780887
153P300_18555785_Chip-Seq_ESCs_Mouse0.96768872
154RUNX_20019798_ChIP-Seq_JUKART_Human0.96635719
155IGF1R_20145208_ChIP-Seq_DFB_Human0.96579120
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96360420
157OCT4_20526341_ChIP-Seq_ESCs_Human0.96016766
158CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95829014
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95363353
160RAC3_21632823_ChIP-Seq_H3396_Human0.94800696
161P300_27268052_Chip-Seq_Bcells_Human0.93552400
162* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93240409
163MAF_26560356_Chip-Seq_TH1_Human0.92925722
164EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92760369
165AR_20517297_ChIP-Seq_VCAP_Human0.91889609
166HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91541864
167MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91339306
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90729647
169* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90619622
170SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89789995
171TAF15_26573619_Chip-Seq_HEK293_Human0.89754671
172CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89730142
173FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89519016
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88482516
175RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88368383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.62351065
2MP0003693_abnormal_embryo_hatching3.26744898
3MP0003136_yellow_coat_color3.07740385
4MP0001986_abnormal_taste_sensitivity2.75124122
5MP0009785_altered_susceptibility_to2.72753373
6MP0002396_abnormal_hematopoietic_system2.62470786
7MP0010094_abnormal_chromosome_stability2.60734103
8MP0005671_abnormal_response_to2.50880890
9MP0008058_abnormal_DNA_repair2.45486500
10MP0001800_abnormal_humoral_immune2.37356792
11MP0008877_abnormal_DNA_methylation2.31343026
12MP0000685_abnormal_immune_system2.28712506
13MP0002148_abnormal_hypersensitivity_rea2.26500070
14MP0002452_abnormal_antigen_presenting2.24928507
15MP0008057_abnormal_DNA_replication2.24210866
16MP0003111_abnormal_nucleus_morphology2.17431040
17MP0002723_abnormal_immune_serum2.14780897
18MP0003646_muscle_fatigue2.12967127
19MP0001790_abnormal_immune_system2.11394890
20MP0005387_immune_system_phenotype2.11394890
21MP0005000_abnormal_immune_tolerance2.10956769
22MP0004808_abnormal_hematopoietic_stem2.10749840
23MP0002419_abnormal_innate_immunity2.05885319
24MP0001819_abnormal_immune_cell2.05817546
25MP0005025_abnormal_response_to2.04843825
26MP0002420_abnormal_adaptive_immunity2.04489494
27MP0002102_abnormal_ear_morphology1.99356779
28MP0002398_abnormal_bone_marrow1.97790937
29MP0000490_abnormal_crypts_of1.97723554
30MP0000569_abnormal_digit_pigmentation1.94419477
31MP0008007_abnormal_cellular_replicative1.92882428
32MP0003718_maternal_effect1.88446421
33MP0006292_abnormal_olfactory_placode1.87448245
34MP0003763_abnormal_thymus_physiology1.86474209
35MP0003436_decreased_susceptibility_to1.84436899
36MP0008875_abnormal_xenobiotic_pharmacok1.81508209
37MP0003077_abnormal_cell_cycle1.80950317
38MP0004043_abnormal_pH_regulation1.79733581
39MP0005464_abnormal_platelet_physiology1.79725462
40MP0003183_abnormal_peptide_metabolism1.77167613
41MP0000716_abnormal_immune_system1.75907146
42MP0000372_irregular_coat_pigmentation1.75257127
43MP0002638_abnormal_pupillary_reflex1.67540181
44MP0005397_hematopoietic_system_phenotyp1.66977853
45MP0001545_abnormal_hematopoietic_system1.66977853
46MP0005551_abnormal_eye_electrophysiolog1.66710917
47MP0010155_abnormal_intestine_physiology1.64774401
48MP0001873_stomach_inflammation1.64342881
49MP0000689_abnormal_spleen_morphology1.61226239
50MP0002722_abnormal_immune_system1.60562469
51MP0008872_abnormal_physiological_respon1.59691095
52MP0002160_abnormal_reproductive_system1.54626599
53MP0002429_abnormal_blood_cell1.54193199
54MP0002132_abnormal_respiratory_system1.53910192
55* MP0000653_abnormal_sex_gland1.51771481
56MP0000631_abnormal_neuroendocrine_gland1.51546123
57MP0005171_absent_coat_pigmentation1.49647920
58MP0000703_abnormal_thymus_morphology1.48881309
59MP0006082_CNS_inflammation1.48655514
60MP0000015_abnormal_ear_pigmentation1.48653702
61MP0002876_abnormal_thyroid_physiology1.45581467
62MP0009333_abnormal_splenocyte_physiolog1.45113144
63MP0003195_calcinosis1.44459850
64MP0004133_heterotaxia1.44021549
65MP0000566_synostosis1.43439327
66MP0002938_white_spotting1.42601917
67MP0002405_respiratory_system_inflammati1.40548317
68MP0009278_abnormal_bone_marrow1.39589946
69MP0002095_abnormal_skin_pigmentation1.38912624
70MP0005646_abnormal_pituitary_gland1.38853066
71MP0009764_decreased_sensitivity_to1.38025490
72MP0005174_abnormal_tail_pigmentation1.35457898
73MP0005410_abnormal_fertilization1.33231328
74MP0000465_gastrointestinal_hemorrhage1.32851942
75MP0001845_abnormal_inflammatory_respons1.31766077
76MP0005310_abnormal_salivary_gland1.31668112
77MP0005389_reproductive_system_phenotype1.29070943
78MP0003724_increased_susceptibility_to1.29005098
79MP0000427_abnormal_hair_cycle1.26401341
80MP0006072_abnormal_retinal_apoptosis1.24904686
81MP0004147_increased_porphyrin_level1.24829272
82MP0009697_abnormal_copulation1.23587253
83MP0001968_abnormal_touch/_nociception1.22484680
84MP0005451_abnormal_body_composition1.21891487
85MP0005253_abnormal_eye_physiology1.20232999
86MP0002653_abnormal_ependyma_morphology1.17920539
87MP0000383_abnormal_hair_follicle1.16839734
88MP0004782_abnormal_surfactant_physiolog1.16789333
89MP0001853_heart_inflammation1.15142084
90MP0008995_early_reproductive_senescence1.13049981
91MP0004142_abnormal_muscle_tone1.12929584
92MP0005083_abnormal_biliary_tract1.12621970
93MP0003786_premature_aging1.12612932
94MP0000678_abnormal_parathyroid_gland1.10209101
95MP0000681_abnormal_thyroid_gland1.09504614
96MP0002019_abnormal_tumor_incidence1.06906064
97MP0008260_abnormal_autophagy1.06734687
98MP0003787_abnormal_imprinting1.05179575
99* MP0002210_abnormal_sex_determination1.04179951
100MP0008961_abnormal_basal_metabolism1.04045766
101MP0001188_hyperpigmentation1.02572235
102MP0008469_abnormal_protein_level1.02106484
103MP0003121_genomic_imprinting0.99902822
104MP0009046_muscle_twitch0.99456194
105* MP0001929_abnormal_gametogenesis0.99404451
106MP0003890_abnormal_embryonic-extraembry0.98895398
107MP0002693_abnormal_pancreas_physiology0.96555442
108MP0004957_abnormal_blastocyst_morpholog0.96441279
109MP0002277_abnormal_respiratory_mucosa0.92843585
110MP0000313_abnormal_cell_death0.92406040
111MP0003943_abnormal_hepatobiliary_system0.91033867
112MP0002163_abnormal_gland_morphology0.90609421
113MP0001919_abnormal_reproductive_system0.88254482
114MP0005075_abnormal_melanosome_morpholog0.87671625
115MP0003937_abnormal_limbs/digits/tail_de0.87210898
116MP0001502_abnormal_circadian_rhythm0.85195372
117* MP0002161_abnormal_fertility/fecundity0.85150499
118MP0003119_abnormal_digestive_system0.85058421
119MP0004885_abnormal_endolymph0.83256638
120MP0005220_abnormal_exocrine_pancreas0.82740282
121* MP0001119_abnormal_female_reproductive0.80319134
122MP0004510_myositis0.79555532
123MP0003123_paternal_imprinting0.78737888
124MP0004947_skin_inflammation0.78288986
125MP0001324_abnormal_eye_pigmentation0.77636985
126MP0001293_anophthalmia0.77165195
127MP0004742_abnormal_vestibular_system0.76119112
128MP0010307_abnormal_tumor_latency0.75098861
129MP0008775_abnormal_heart_ventricle0.74994859
130MP0006035_abnormal_mitochondrial_morpho0.73951858
131MP0000858_altered_metastatic_potential0.73750256
132* MP0003698_abnormal_male_reproductive0.72963022
133MP0002928_abnormal_bile_duct0.72877655
134MP0006276_abnormal_autonomic_nervous0.72748495
135MP0003866_abnormal_defecation0.72490794
136* MP0003699_abnormal_female_reproductive0.71745593
137MP0005195_abnormal_posterior_eye0.71499305
138MP0002075_abnormal_coat/hair_pigmentati0.70822502
139MP0002837_dystrophic_cardiac_calcinosis0.69644507
140MP0001764_abnormal_homeostasis0.69332749
141MP0002557_abnormal_social/conspecific_i0.69270587
142MP0005084_abnormal_gallbladder_morpholo0.68229146
143MP0005647_abnormal_sex_gland0.68036767
144MP0002933_joint_inflammation0.67778308
145MP0005645_abnormal_hypothalamus_physiol0.67083191
146MP0001529_abnormal_vocalization0.66418490
147MP0008932_abnormal_embryonic_tissue0.66235746
148* MP0001145_abnormal_male_reproductive0.66160343
149MP0003828_pulmonary_edema0.65150036
150MP0002006_tumorigenesis0.64215913
151MP0002735_abnormal_chemical_nociception0.64042336
152MP0008789_abnormal_olfactory_epithelium0.64003955
153MP0003252_abnormal_bile_duct0.63896768
154MP0005409_darkened_coat_color0.63748962
155MP0005379_endocrine/exocrine_gland_phen0.63708087
156MP0002234_abnormal_pharynx_morphology0.61943136
157MP0002736_abnormal_nociception_after0.61768816

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.13333928
2Chromsome breakage (HP:0040012)4.91189009
3Recurrent abscess formation (HP:0002722)3.67662029
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.59223493
5Molar tooth sign on MRI (HP:0002419)3.48656654
6Abnormality of midbrain morphology (HP:0002418)3.48656654
7Pancreatic cysts (HP:0001737)3.48531118
8Nephronophthisis (HP:0000090)3.39670161
9Agammaglobulinemia (HP:0004432)3.36059341
10Pancreatic fibrosis (HP:0100732)3.35749748
11Recurrent fungal infections (HP:0002841)3.31227217
12Panhypogammaglobulinemia (HP:0003139)3.19695627
13Recurrent cutaneous fungal infections (HP:0011370)3.19678802
14Chronic mucocutaneous candidiasis (HP:0002728)3.19678802
15Congenital stationary night blindness (HP:0007642)3.18742089
16Recurrent bacterial skin infections (HP:0005406)3.16817825
17Birth length less than 3rd percentile (HP:0003561)3.12816271
18Meningitis (HP:0001287)3.08868743
19Duplicated collecting system (HP:0000081)3.05354188
20Recurrent viral infections (HP:0004429)3.04972020
21Abnormality of the renal collecting system (HP:0004742)3.04841226
22True hermaphroditism (HP:0010459)3.04158152
23Abnormality of the renal medulla (HP:0100957)3.03549437
24Abnormality of the renal cortex (HP:0011035)2.99356099
25Patellar aplasia (HP:0006443)2.98554871
26Reduced antithrombin III activity (HP:0001976)2.92744654
27Recurrent pneumonia (HP:0006532)2.90558850
28IgM deficiency (HP:0002850)2.87727893
29Abnormal number of erythroid precursors (HP:0012131)2.84734962
30Eczematoid dermatitis (HP:0000976)2.82678586
31Petechiae (HP:0000967)2.82419886
32Aplasia/Hypoplasia of the patella (HP:0006498)2.82096861
33Type II lissencephaly (HP:0007260)2.78078513
34Attenuation of retinal blood vessels (HP:0007843)2.76596451
35Abnormality of chromosome stability (HP:0003220)2.75551210
36Hypoplasia of the pons (HP:0012110)2.74782989
37Cystic liver disease (HP:0006706)2.71821095
38Abnormality of the pons (HP:0007361)2.69669013
39Abnormality of T cell physiology (HP:0011840)2.67127738
40Type I transferrin isoform profile (HP:0003642)2.66780006
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.66067307
42Abnormality of cells of the erythroid lineage (HP:0012130)2.65351083
43Abnormality of the preputium (HP:0100587)2.63609377
44Retrobulbar optic neuritis (HP:0100654)2.63324407
45Optic neuritis (HP:0100653)2.63324407
46Obstructive lung disease (HP:0006536)2.61318604
47Chronic obstructive pulmonary disease (HP:0006510)2.61318604
48Abnormality of DNA repair (HP:0003254)2.59624411
49Abnormality of B cell number (HP:0010975)2.58271692
50B lymphocytopenia (HP:0010976)2.58271692
51Rib fusion (HP:0000902)2.54418863
52Recurrent lower respiratory tract infections (HP:0002783)2.53232897
53Cerebellar dysplasia (HP:0007033)2.49392584
54Absent thumb (HP:0009777)2.48619406
55Meckel diverticulum (HP:0002245)2.47193790
56Myositis (HP:0100614)2.47076484
57Clubbing of toes (HP:0100760)2.45623042
58Recurrent skin infections (HP:0001581)2.45132256
59Abnormality of macrophages (HP:0004311)2.43246510
60Cellulitis (HP:0100658)2.43102123
61Chronic hepatic failure (HP:0100626)2.42702483
62Abnormality of T cells (HP:0002843)2.41893335
63Prolonged bleeding time (HP:0003010)2.39874677
64Patchy hypopigmentation of hair (HP:0011365)2.39634610
65Pendular nystagmus (HP:0012043)2.39435800
66Sloping forehead (HP:0000340)2.37287148
67Inflammation of the large intestine (HP:0002037)2.36968810
68Tubular atrophy (HP:0000092)2.35502225
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35389953
70Abnormal protein N-linked glycosylation (HP:0012347)2.35389953
71Abnormal protein glycosylation (HP:0012346)2.35389953
72Abnormal glycosylation (HP:0012345)2.35389953
73Abnormality of the ileum (HP:0001549)2.34459985
74Prostate neoplasm (HP:0100787)2.33131627
75Reticulocytopenia (HP:0001896)2.32461315
76Sclerocornea (HP:0000647)2.30336245
77Protruding tongue (HP:0010808)2.29542726
78Bone marrow hypocellularity (HP:0005528)2.28976071
79IgG deficiency (HP:0004315)2.28515933
80Hypoplastic iliac wings (HP:0002866)2.27665446
81Chronic diarrhea (HP:0002028)2.25849785
82Ectopic kidney (HP:0000086)2.24537805
83Gastrointestinal inflammation (HP:0004386)2.23399168
84Osteomyelitis (HP:0002754)2.23144169
85Vasculitis (HP:0002633)2.22966501
86Mediastinal lymphadenopathy (HP:0100721)2.22506855
87Bile duct proliferation (HP:0001408)2.21251091
88Abnormal biliary tract physiology (HP:0012439)2.21251091
89Neutropenia (HP:0001875)2.21115711
90Recurrent sinusitis (HP:0011108)2.17623646
91Orchitis (HP:0100796)2.16347684
92Aplasia/Hypoplasia of the fovea (HP:0008060)2.15080101
93Hypoplasia of the fovea (HP:0007750)2.15080101
94Recurrent gram-negative bacterial infections (HP:0005420)2.15006469
95Thyroiditis (HP:0100646)2.12136981
96Type 2 muscle fiber atrophy (HP:0003554)2.11847101
97Abnormality of the intervertebral disk (HP:0005108)2.10856789
98Lymphoma (HP:0002665)2.09742375
99Medial flaring of the eyebrow (HP:0010747)2.08974864
100Polydipsia (HP:0001959)2.06868530
101Abnormal drinking behavior (HP:0030082)2.06868530
102Myelodysplasia (HP:0002863)2.06542642
103Renal cortical cysts (HP:0000803)2.05047748
104Abnormality of the prostate (HP:0008775)2.05020596
105Encephalitis (HP:0002383)2.02405371
106Aplastic anemia (HP:0001915)1.99633460
107Abnormality of alanine metabolism (HP:0010916)1.97551902
108Hyperalaninemia (HP:0003348)1.97551902
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97551902
110Hypergonadotropic hypogonadism (HP:0000815)1.97309627
111Volvulus (HP:0002580)1.95897787
112Basal ganglia calcification (HP:0002135)1.94610638
113Leukopenia (HP:0001882)1.94229382
114Congenital hepatic fibrosis (HP:0002612)1.93402513
115Abnormal rod and cone electroretinograms (HP:0008323)1.92066828
116Short thumb (HP:0009778)1.91068159
117Abnormality of the carotid arteries (HP:0005344)1.90882246
118Tetany (HP:0001281)1.90628423
119Agnosia (HP:0010524)1.90467608
120Lymphopenia (HP:0001888)1.89530755
121Optic nerve coloboma (HP:0000588)1.89373481
122Preaxial hand polydactyly (HP:0001177)1.88732921
123Colon cancer (HP:0003003)1.88506419
124Symptomatic seizures (HP:0011145)1.87592227
125Muscle fiber atrophy (HP:0100295)1.87179023
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86366890
127Hypoplasia of the thymus (HP:0000778)1.85866531
128Oligodactyly (hands) (HP:0001180)1.85813128
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.85731740
130Gingivitis (HP:0000230)1.85549814
131Postaxial foot polydactyly (HP:0001830)1.85493962
132Epistaxis (HP:0000421)1.84838683
133Abnormality of T cell number (HP:0011839)1.83453383
134Methylmalonic acidemia (HP:0002912)1.82728676
135Colitis (HP:0002583)1.82122658
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.82007028
137Keratoconjunctivitis (HP:0001096)1.81434786
138Tachypnea (HP:0002789)1.81054445
139Recurrent bronchitis (HP:0002837)1.80188451
140Genetic anticipation (HP:0003743)1.79890397
141Tubulointerstitial nephritis (HP:0001970)1.79693372
142Abnormality of cochlea (HP:0000375)1.79604741
143Severe combined immunodeficiency (HP:0004430)1.79471922
144T lymphocytopenia (HP:0005403)1.79092508
145Facial hemangioma (HP:0000329)1.78840081
146Alveolar cell carcinoma (HP:0006519)1.78546108
147Vacuolated lymphocytes (HP:0001922)1.78248843
148Homocystinuria (HP:0002156)1.78053096
149Abnormality of homocysteine metabolism (HP:0010919)1.78053096
150Decreased central vision (HP:0007663)1.77400618
151Small intestinal stenosis (HP:0012848)1.77104483
152Duodenal stenosis (HP:0100867)1.77104483
153Anencephaly (HP:0002323)1.77071366
154Polyuria (HP:0000103)1.76936001
155Retinal dysplasia (HP:0007973)1.76382589
15611 pairs of ribs (HP:0000878)1.75966290
157Hyperventilation (HP:0002883)1.75927945
158Lissencephaly (HP:0001339)1.74586746
159Clumsiness (HP:0002312)1.74509422
160Chronic otitis media (HP:0000389)1.74416671
161Bony spicule pigmentary retinopathy (HP:0007737)1.74006332
162Abnormal spermatogenesis (HP:0008669)1.73879627
163Impulsivity (HP:0100710)1.73658950
164Hypochromic anemia (HP:0001931)1.73186321
165Anomalous pulmonary venous return (HP:0010772)1.72332332
166Asplenia (HP:0001746)1.72250775
167Squamous cell carcinoma (HP:0002860)1.71825831
168Multicystic kidney dysplasia (HP:0000003)1.71654756
169Concave nail (HP:0001598)1.69148604
170Highly arched eyebrow (HP:0002553)1.68880818
171Triphalangeal thumb (HP:0001199)1.68176008
172Astigmatism (HP:0000483)1.68076662
173Abnormality of the duodenum (HP:0002246)1.67697388
174Dandy-Walker malformation (HP:0001305)1.66377473
175Partial agenesis of the corpus callosum (HP:0001338)1.66133154
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.65544169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.89089576
2WNK43.69578560
3IRAK33.25160061
4PNCK3.19347151
5BMPR1B2.92023377
6MAP4K12.91752523
7IRAK42.85614472
8TXK2.49042627
9TEC2.30866834
10BLK2.28706735
11MAP3K142.27471905
12BTK2.10810692
13ZAK2.03079437
14MKNK21.86675044
15PIM21.86189411
16JAK31.81600959
17EIF2AK21.81466136
18CCNB11.78227656
19MAP4K21.75043761
20EIF2AK31.75027826
21STK41.74692375
22ADRBK21.71288653
23BRD41.69346474
24STK161.69175016
25CAMK1G1.67043874
26INSRR1.65702821
27PASK1.63401455
28SYK1.60077085
29VRK11.55287106
30PIM11.54315176
31CSF1R1.54155267
32MKNK11.53938108
33KIT1.53615439
34CDK121.49174612
35TAOK31.48848901
36OXSR11.45237449
37MET1.42052566
38DYRK31.41377206
39IKBKE1.40970764
40CDC71.39064084
41VRK21.38511093
42NEK21.34025673
43PTK2B1.31290079
44TNIK1.30255316
45MAPK131.29552147
46MAPK151.27701977
47IKBKB1.24918814
48CLK11.23835785
49SIK31.20391386
50RPS6KA41.19676376
51SRPK11.19025608
52SIK21.18814654
53TYK21.16556813
54ATR1.16452749
55STK391.16405728
56MAP3K41.12970642
57LYN1.12712326
58WNK31.12637397
59TRPM71.11843508
60NLK1.08861740
61TBK11.08235111
62ITK1.03770016
63EIF2AK11.02228410
64FLT31.01543951
65ZAP701.00645724
66BMX0.94434116
67CDK40.93159598
68MAP2K60.92470499
69NME10.88264345
70CAMK1D0.88222238
71EEF2K0.87215635
72PIK3CG0.87109068
73PLK40.85676895
74CHUK0.82334991
75CDK70.81503260
76ADRBK10.81501197
77WEE10.80566162
78BRSK20.80412596
79HCK0.79823707
80CDK80.79749002
81MAP3K100.79026570
82WNK10.78320589
83MAP2K30.76930202
84TGFBR10.76482072
85MAP2K20.73908056
86RPS6KA50.73357685
87CHEK20.72149289
88PLK10.71313432
89MAPKAPK50.69999369
90AURKB0.69748128
91MAP3K70.69064472
92PINK10.68509882
93STK240.67226082
94ACVR1B0.65703693
95YES10.64545503
96JAK10.64094858
97BCKDK0.63955817
98GRK10.62936701
99OBSCN0.62843232
100LCK0.62660436
101TNK20.62602512
102TTK0.61917726
103MAP3K30.61545357
104TAOK20.61051419
105MELK0.60954621
106CDK30.59537493
107TLK10.58897662
108NUAK10.58676323
109CDK10.57713941
110CASK0.57288824
111DAPK20.56719839
112ATM0.56571247
113PRKAA10.56454077
114BUB10.56389412
115MAPK110.56144750
116CDK20.55908866
117PRKCI0.55787959
118STK100.55518100
119DYRK20.54691765
120PRPF4B0.54437252
121PLK30.53011912
122NEK10.52598172
123TYRO30.52555418
124CHEK10.51867034
125MATK0.51223934
126PDK20.50442404
127MARK30.50067613
128CDK90.49734799
129MUSK0.48793463
130TGFBR20.48369116
131RPS6KB10.48045386
132MAPKAPK30.46925786
133PLK20.46309895
134NEK60.45377484
135SGK20.44531715
136NME20.44224832
137RPS6KB20.43331689
138TAF10.42490809
139DYRK1B0.42245936
140PRKCD0.41714449
141PRKCQ0.41590560
142ERBB30.40748235
143AKT10.39110724
144BRSK10.38830971
145NTRK30.37186378
146SGK10.36330177
147AURKA0.35471151
148STK30.33762781
149RPS6KA60.32536152
150MAPK30.30413492

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.24872043
2Base excision repair_Homo sapiens_hsa034102.98886760
3Homologous recombination_Homo sapiens_hsa034402.94660975
4Mismatch repair_Homo sapiens_hsa034302.73894658
5Fanconi anemia pathway_Homo sapiens_hsa034602.72271309
6Caffeine metabolism_Homo sapiens_hsa002322.65737605
7Primary immunodeficiency_Homo sapiens_hsa053402.61826549
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.43341041
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25875423
10Linoleic acid metabolism_Homo sapiens_hsa005912.22973219
11Non-homologous end-joining_Homo sapiens_hsa034502.18239606
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.13829193
13Leishmaniasis_Homo sapiens_hsa051402.00308488
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93740931
15Phototransduction_Homo sapiens_hsa047441.93410516
16Herpes simplex infection_Homo sapiens_hsa051681.89923914
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88740771
18Measles_Homo sapiens_hsa051621.85862332
19Basal transcription factors_Homo sapiens_hsa030221.85790101
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81459055
21Butanoate metabolism_Homo sapiens_hsa006501.81402132
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79719198
23Allograft rejection_Homo sapiens_hsa053301.78154771
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76224594
25Cell cycle_Homo sapiens_hsa041101.71522237
26Hematopoietic cell lineage_Homo sapiens_hsa046401.63875366
27Nitrogen metabolism_Homo sapiens_hsa009101.63084154
28Pyrimidine metabolism_Homo sapiens_hsa002401.53085296
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51558329
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50333820
31Nucleotide excision repair_Homo sapiens_hsa034201.50103984
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.48610993
33Lysine degradation_Homo sapiens_hsa003101.48414649
34Asthma_Homo sapiens_hsa053101.44781204
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44575698
36B cell receptor signaling pathway_Homo sapiens_hsa046621.40752775
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.40215433
38Spliceosome_Homo sapiens_hsa030401.38355380
39Graft-versus-host disease_Homo sapiens_hsa053321.35379954
40Other glycan degradation_Homo sapiens_hsa005111.33857668
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31091357
42Sulfur relay system_Homo sapiens_hsa041221.30541478
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.27600467
44Legionellosis_Homo sapiens_hsa051341.27338908
45Autoimmune thyroid disease_Homo sapiens_hsa053201.25968612
46Oxidative phosphorylation_Homo sapiens_hsa001901.22927105
47Ether lipid metabolism_Homo sapiens_hsa005651.18618526
48RNA degradation_Homo sapiens_hsa030181.17664032
49Systemic lupus erythematosus_Homo sapiens_hsa053221.16843037
50Olfactory transduction_Homo sapiens_hsa047401.14582999
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14573129
52RNA polymerase_Homo sapiens_hsa030201.13621293
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12979778
54Tryptophan metabolism_Homo sapiens_hsa003801.11484591
55Influenza A_Homo sapiens_hsa051641.10897009
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10672674
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.09875938
58Osteoclast differentiation_Homo sapiens_hsa043801.06711941
59Antigen processing and presentation_Homo sapiens_hsa046121.06694146
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03692981
61p53 signaling pathway_Homo sapiens_hsa041151.03219796
62Huntingtons disease_Homo sapiens_hsa050161.01994832
63Epstein-Barr virus infection_Homo sapiens_hsa051691.01948181
64Type I diabetes mellitus_Homo sapiens_hsa049401.01289938
65Parkinsons disease_Homo sapiens_hsa050121.00904412
66Apoptosis_Homo sapiens_hsa042101.00794830
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99768295
68Protein export_Homo sapiens_hsa030600.94597284
69Propanoate metabolism_Homo sapiens_hsa006400.92829873
70Hepatitis B_Homo sapiens_hsa051610.92263492
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91647836
72TNF signaling pathway_Homo sapiens_hsa046680.91539377
73Tuberculosis_Homo sapiens_hsa051520.89387898
74Taste transduction_Homo sapiens_hsa047420.89364794
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88249868
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88182549
77Pertussis_Homo sapiens_hsa051330.88098694
78Purine metabolism_Homo sapiens_hsa002300.87015325
79Malaria_Homo sapiens_hsa051440.86639153
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85776389
81One carbon pool by folate_Homo sapiens_hsa006700.85736931
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.84418409
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83635740
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83245139
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79927441
86Nicotine addiction_Homo sapiens_hsa050330.79926642
87Peroxisome_Homo sapiens_hsa041460.79832748
88Toxoplasmosis_Homo sapiens_hsa051450.77890211
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76960932
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76204149
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75352662
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74738739
93Viral carcinogenesis_Homo sapiens_hsa052030.73881863
94Rheumatoid arthritis_Homo sapiens_hsa053230.73681534
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73361836
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72566827
97N-Glycan biosynthesis_Homo sapiens_hsa005100.71974179
98HTLV-I infection_Homo sapiens_hsa051660.68910428
99Sphingolipid metabolism_Homo sapiens_hsa006000.68624834
100RNA transport_Homo sapiens_hsa030130.67972983
101Proteasome_Homo sapiens_hsa030500.63600229
102Ribosome_Homo sapiens_hsa030100.62433483
103ABC transporters_Homo sapiens_hsa020100.62342686
104Staphylococcus aureus infection_Homo sapiens_hsa051500.62020063
105Retinol metabolism_Homo sapiens_hsa008300.61937045
106Metabolic pathways_Homo sapiens_hsa011000.61843000
107Small cell lung cancer_Homo sapiens_hsa052220.61736126
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61611705
109mRNA surveillance pathway_Homo sapiens_hsa030150.60588722
110Chemokine signaling pathway_Homo sapiens_hsa040620.57005103
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55621268
112Basal cell carcinoma_Homo sapiens_hsa052170.55195558
113Hepatitis C_Homo sapiens_hsa051600.54851834
114Arachidonic acid metabolism_Homo sapiens_hsa005900.54139397
115Vitamin digestion and absorption_Homo sapiens_hsa049770.53544281
116Shigellosis_Homo sapiens_hsa051310.53329279
117T cell receptor signaling pathway_Homo sapiens_hsa046600.52819736
118Chronic myeloid leukemia_Homo sapiens_hsa052200.51857801
119Steroid biosynthesis_Homo sapiens_hsa001000.51616015
120Acute myeloid leukemia_Homo sapiens_hsa052210.49883108
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.49573444
122African trypanosomiasis_Homo sapiens_hsa051430.49400635
123Phagosome_Homo sapiens_hsa041450.48792990
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46738593
125Salmonella infection_Homo sapiens_hsa051320.43955357
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42265919
127Notch signaling pathway_Homo sapiens_hsa043300.41356682
128Chemical carcinogenesis_Homo sapiens_hsa052040.41310291
129Ovarian steroidogenesis_Homo sapiens_hsa049130.41035336
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.40480370
131Fat digestion and absorption_Homo sapiens_hsa049750.38020139
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.36952465
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36506365
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36099604
135Fatty acid metabolism_Homo sapiens_hsa012120.35709430
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35325771
137Selenocompound metabolism_Homo sapiens_hsa004500.35059029
138Alzheimers disease_Homo sapiens_hsa050100.34938817
139Dorso-ventral axis formation_Homo sapiens_hsa043200.34543619
140Folate biosynthesis_Homo sapiens_hsa007900.34427064
141Platelet activation_Homo sapiens_hsa046110.33520706
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33079557
143Alcoholism_Homo sapiens_hsa050340.33031460
144Oocyte meiosis_Homo sapiens_hsa041140.32854735
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32439172
146Vitamin B6 metabolism_Homo sapiens_hsa007500.32236626
147Regulation of autophagy_Homo sapiens_hsa041400.32111757
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30871953
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28788264
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.26694955
151Morphine addiction_Homo sapiens_hsa050320.24604641
152Cardiac muscle contraction_Homo sapiens_hsa042600.24534566
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23800222
154Fructose and mannose metabolism_Homo sapiens_hsa000510.23719098
155Fatty acid biosynthesis_Homo sapiens_hsa000610.23227198
156Glycerolipid metabolism_Homo sapiens_hsa005610.21135748
157Calcium signaling pathway_Homo sapiens_hsa040200.19189633

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