ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	6.58028369
2	meiotic chromosome segregation (GO:0045132)	6.20387820
3	DNA synthesis involved in DNA repair (GO:0000731)	5.85666338
4	chromosome organization involved in meiosis (GO:0070192)	5.76110395
5	mitotic chromosome condensation (GO:0007076)	5.49151234
6	DNA unwinding involved in DNA replication (GO:0006268)	5.31233756
7	synaptonemal complex assembly (GO:0007130)	4.96798021
8	male meiosis I (GO:0007141)	4.88081334
9	DNA topological change (GO:0006265)	4.79719423
10	nuclear pore complex assembly (GO:0051292)	4.79156769
11	mitotic sister chromatid cohesion (GO:0007064)	4.64855850
12	sister chromatid cohesion (GO:0007062)	4.56443790
13	histone H3-K9 demethylation (GO:0033169)	4.36242533
14	DNA strand elongation involved in DNA replication (GO:0006271)	4.32696652
15	synaptonemal complex organization (GO:0070193)	4.29740790
16	regulation of histone H3-K9 methylation (GO:0051570)	4.29619080
17	DNA strand elongation (GO:0022616)	4.19443799
18	telomere maintenance via semi-conservative replication (GO:0032201)	4.18182831
19	regulation of translational fidelity (GO:0006450)	4.17149714
20	DNA replication initiation (GO:0006270)	4.16754613
21	mitotic sister chromatid segregation (GO:0000070)	4.14485174
22	histone H3-K36 demethylation (GO:0070544)	4.14166791
23	DNA methylation involved in gamete generation (GO:0043046)	4.10413526
24	meiotic nuclear division (GO:0007126)	4.01227396
25	sister chromatid segregation (GO:0000819)	3.96409612
26	meiosis I (GO:0007127)	3.95134283
27	nuclear pore organization (GO:0006999)	3.93283572
28	histone H2A acetylation (GO:0043968)	3.88317950
29	chromosome condensation (GO:0030261)	3.88228254
30	piRNA metabolic process (GO:0034587)	3.87755439
31	diterpenoid biosynthetic process (GO:0016102)	3.81990245
32	mitotic nuclear envelope disassembly (GO:0007077)	3.79095583
33	regulation of RNA export from nucleus (GO:0046831)	3.78922273
34	intra-S DNA damage checkpoint (GO:0031573)	3.77613761
35	cilium or flagellum-dependent cell motility (GO:0001539)	3.75006446
36	regulation of histone H3-K4 methylation (GO:0051569)	3.71408482
37	telomere maintenance via recombination (GO:0000722)	3.67869067
38	DNA replication checkpoint (GO:0000076)	3.64049961
39	DNA packaging (GO:0006323)	3.62486475
40	mitotic recombination (GO:0006312)	3.61603723
41	male meiosis (GO:0007140)	3.61594647
42	regulation of histone H3-K27 methylation (GO:0061085)	3.57506235
43	motile cilium assembly (GO:0044458)	3.55173896
44	negative regulation of erythrocyte differentiation (GO:0045647)	3.52739106
45	centriole assembly (GO:0098534)	3.52086782
46	nuclear envelope disassembly (GO:0051081)	3.47149874
47	membrane disassembly (GO:0030397)	3.47149874
48	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.42872866
49	positive regulation of histone H3-K4 methylation (GO:0051571)	3.40842241
50	meiotic cell cycle process (GO:1903046)	3.40538298
51	pore complex assembly (GO:0046931)	3.34262576
52	poly(A)+ mRNA export from nucleus (GO:0016973)	3.32838748
53	axonemal dynein complex assembly (GO:0070286)	3.32430651
54	kinetochore organization (GO:0051383)	3.31671516
55	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.27839729
56	regulation of DNA endoreduplication (GO:0032875)	3.27253669
57	positive regulation of histone methylation (GO:0031062)	3.26878225
58	regulation of histone methylation (GO:0031060)	3.26733733
59	mRNA cleavage (GO:0006379)	3.26723052
60	DNA conformation change (GO:0071103)	3.22856473
61	chromosome segregation (GO:0007059)	3.19440265
62	proline biosynthetic process (GO:0006561)	3.14450183
63	pentose-phosphate shunt (GO:0006098)	3.12347595
64	microtubule depolymerization (GO:0007019)	3.09793836
65	regulation of nucleobase-containing compound transport (GO:0032239)	3.03299554
66	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.98159382
67	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.98159382
68	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.98159382
69	reciprocal DNA recombination (GO:0035825)	2.96878794
70	reciprocal meiotic recombination (GO:0007131)	2.96878794
71	chromosome organization (GO:0051276)	2.96851691
72	dosage compensation (GO:0007549)	2.96821221
73	histone H4 deacetylation (GO:0070933)	2.94240298
74	DNA duplex unwinding (GO:0032508)	2.93895773
75	DNA biosynthetic process (GO:0071897)	2.90289138
76	folic acid-containing compound biosynthetic process (GO:0009396)	2.88500681
77	DNA ligation (GO:0006266)	2.87087818
78	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.86349916
79	protein localization to chromosome, centromeric region (GO:0071459)	2.86256297
80	nuclear envelope organization (GO:0006998)	2.83697553
81	gene silencing by RNA (GO:0031047)	2.82973384
82	positive regulation of gene expression, epigenetic (GO:0045815)	2.82333080
83	resolution of meiotic recombination intermediates (GO:0000712)	2.81449872
84	terpenoid biosynthetic process (GO:0016114)	2.81377949
85	positive regulation of cellular response to oxidative stress (GO:1900409)	2.80762169
86	positive regulation of response to oxidative stress (GO:1902884)	2.80762169
87	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.80566380
88	DNA geometric change (GO:0032392)	2.79566406
89	regulation of sister chromatid cohesion (GO:0007063)	2.78257245
90	snRNA processing (GO:0016180)	2.75491608
91	mannose metabolic process (GO:0006013)	2.74622214
92	positive regulation of cell cycle checkpoint (GO:1901978)	2.73188174
93	protein localization to chromosome (GO:0034502)	2.72539874
94	mRNA export from nucleus (GO:0006406)	2.69979095
95	snRNA metabolic process (GO:0016073)	2.68993590
96	DNA methylation (GO:0006306)	2.66595865
97	DNA alkylation (GO:0006305)	2.66595865
98	positive regulation of chromosome segregation (GO:0051984)	2.65848915
99	negative regulation of mRNA processing (GO:0050686)	2.65201032
100	COPI coating of Golgi vesicle (GO:0048205)	2.64519917

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.24619669
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.08774035
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.29927792
4	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.96581491
5	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.96409794
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.89822516
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.85619245
8	VDR_21846776_ChIP-Seq_THP-1_Human	2.43732028
9	MYC_22102868_ChIP-Seq_BL_Human	2.43731499
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.43508954
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.40463137
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.95542288
13	KDM5A_27292631_Chip-Seq_BREAST_Human	1.94491726
14	CIITA_25753668_ChIP-Seq_RAJI_Human	1.91313195
15	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.88116812
16	XRN2_22483619_ChIP-Seq_HELA_Human	1.86759016
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.82740189
18	NCOR1_26117541_ChIP-Seq_K562_Human	1.78945871
19	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.77273902
20	DCP1A_22483619_ChIP-Seq_HELA_Human	1.76765029
21	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.75403981
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.72778296
23	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.67822373
24	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.66041877
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65609524
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.64968246
27	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.64546814
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59130600
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57792270
30	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56615684
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.54570263
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53410179
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.53085815
34	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.52802014
35	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.50242139
36	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.48723367
37	ZNF263_19887448_ChIP-Seq_K562_Human	1.47128583
38	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.46143744
39	AR_21909140_ChIP-Seq_LNCAP_Human	1.45934096
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.43364909
41	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.42924075
42	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.42441490
43	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.41085451
44	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.40815287
45	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.40749085
46	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.40129037
47	MAF_26560356_Chip-Seq_TH2_Human	1.37714217
48	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.33690179
49	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.33590076
50	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.32981383
51	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.32943259
52	MAF_26560356_Chip-Seq_TH1_Human	1.31494612
53	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.30802307
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29151388
55	UTX_26944678_Chip-Seq_JUKART_Human	1.28632232
56	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.25216509
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24657978
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24462658
59	P68_20966046_ChIP-Seq_HELA_Human	1.24156528
60	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23406626
61	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21695029
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20191321
63	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19429866
64	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.19201641
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19163811
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.18650038
67	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17839626
68	TFEB_21752829_ChIP-Seq_HELA_Human	1.16054636
69	VDR_23849224_ChIP-Seq_CD4+_Human	1.15230647
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.14639258
71	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.14472418
72	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.13643309
73	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12955332
74	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12941538
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12173548
76	LXR_22292898_ChIP-Seq_THP-1_Human	1.11876898
77	MYB_26560356_Chip-Seq_TH1_Human	1.11594963
78	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.11333718
79	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.10499732
80	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.09042968
81	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.08822583
82	VDR_24763502_ChIP-Seq_THP-1_Human	1.07935882
83	CHD1_26751641_Chip-Seq_LNCaP_Human	1.07631797
84	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.07549413
85	PHF8_20622854_ChIP-Seq_HELA_Human	1.06968811
86	TCF7_22412390_ChIP-Seq_EML_Mouse	1.06910582
87	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06358090
88	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.06111677
89	SMC4_20622854_ChIP-Seq_HELA_Human	1.03537779
90	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.02748090
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02586730
92	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.00221667
93	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.00151363
94	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.00122044
95	SPI1_23547873_ChIP-Seq_NB4_Human	0.97397144
96	KDM2B_26808549_Chip-Seq_DND41_Human	0.95796779
97	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.95210885
98	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.95188746
99	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94655727
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.94307797

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	4.09914402
2	MP0003111_abnormal_nucleus_morphology	3.64455188
3	MP0008058_abnormal_DNA_repair	3.37505903
4	MP0008057_abnormal_DNA_replication	3.32665823
5	MP0003693_abnormal_embryo_hatching	3.15038532
6	MP0002396_abnormal_hematopoietic_system	2.96038817
7	MP0008995_early_reproductive_senescence	2.77642185
8	MP0008007_abnormal_cellular_replicative	2.69714680
9	MP0003172_abnormal_lysosome_physiology	2.61820582
10	MP0003077_abnormal_cell_cycle	2.50491597
11	MP0004957_abnormal_blastocyst_morpholog	2.42503299
12	MP0001929_abnormal_gametogenesis	2.32638937
13	MP0003786_premature_aging	2.32204263
14	MP0005058_abnormal_lysosome_morphology	2.28997964
15	MP0002210_abnormal_sex_determination	2.26717862
16	MP0008877_abnormal_DNA_methylation	2.16162611
17	MP0004808_abnormal_hematopoietic_stem	2.05529482
18	MP0000678_abnormal_parathyroid_gland	1.95187748
19	MP0001145_abnormal_male_reproductive	1.92694200
20	MP0005076_abnormal_cell_differentiation	1.88494349
21	MP0002009_preneoplasia	1.85636091
22	MP0005220_abnormal_exocrine_pancreas	1.82507584
23	MP0003656_abnormal_erythrocyte_physiolo	1.80209498
24	MP0009278_abnormal_bone_marrow	1.78207518
25	MP0003698_abnormal_male_reproductive	1.76928256
26	MP0005645_abnormal_hypothalamus_physiol	1.72895208
27	MP0000653_abnormal_sex_gland	1.66334169
28	MP0006036_abnormal_mitochondrial_physio	1.55115004
29	MP0002160_abnormal_reproductive_system	1.54896270
30	MP0000350_abnormal_cell_proliferation	1.52648718
31	MP0001545_abnormal_hematopoietic_system	1.47109396
32	MP0005397_hematopoietic_system_phenotyp	1.47109396
33	MP0002139_abnormal_hepatobiliary_system	1.45931621
34	MP0000013_abnormal_adipose_tissue	1.45869183
35	MP0005451_abnormal_body_composition	1.45614756
36	MP0004185_abnormal_adipocyte_glucose	1.44358534
37	MP0010307_abnormal_tumor_latency	1.42238255
38	MP0008932_abnormal_embryonic_tissue	1.40920683
39	MP0000703_abnormal_thymus_morphology	1.37485407
40	MP0001730_embryonic_growth_arrest	1.35898844
41	MP0009697_abnormal_copulation	1.34959807
42	MP0002132_abnormal_respiratory_system	1.33928919
43	MP0000313_abnormal_cell_death	1.33719473
44	MP0000003_abnormal_adipose_tissue	1.31868783
45	MP0001672_abnormal_embryogenesis/_devel	1.30524439
46	MP0005380_embryogenesis_phenotype	1.30524439
47	MP0001661_extended_life_span	1.30117101
48	MP0005083_abnormal_biliary_tract	1.28126259
49	MP0000015_abnormal_ear_pigmentation	1.27760741
50	MP0001697_abnormal_embryo_size	1.27517214
51	MP0002166_altered_tumor_susceptibility	1.27136098
52	MP0003984_embryonic_growth_retardation	1.24499643
53	MP0002019_abnormal_tumor_incidence	1.24332599
54	MP0003943_abnormal_hepatobiliary_system	1.24287961
55	MP0002080_prenatal_lethality	1.21426185
56	MP0002088_abnormal_embryonic_growth/wei	1.19125936
57	MP0004019_abnormal_vitamin_homeostasis	1.16637019
58	MP0002970_abnormal_white_adipose	1.14690983
59	MP0006035_abnormal_mitochondrial_morpho	1.12174960
60	MP0005174_abnormal_tail_pigmentation	1.10555358
61	MP0002161_abnormal_fertility/fecundity	1.10368835
62	MP0002398_abnormal_bone_marrow	1.10037532
63	MP0001944_abnormal_pancreas_morphology	1.08945191
64	MP0005666_abnormal_adipose_tissue	1.08799987
65	MP0003763_abnormal_thymus_physiology	1.06868996
66	MP0002138_abnormal_hepatobiliary_system	1.06199330
67	MP0003718_maternal_effect	1.01271581
68	MP0000490_abnormal_crypts_of	1.00464257
69	MP0003699_abnormal_female_reproductive	0.99253393
70	MP0003806_abnormal_nucleotide_metabolis	0.99084019
71	MP0002722_abnormal_immune_system	0.97386564
72	MP0001873_stomach_inflammation	0.96820294
73	MP0005409_darkened_coat_color	0.94425583
74	MP0004147_increased_porphyrin_level	0.94238299
75	MP0005375_adipose_tissue_phenotype	0.91913525
76	MP0001764_abnormal_homeostasis	0.90807161
77	MP0000566_synostosis	0.89789634
78	MP0003123_paternal_imprinting	0.86865170
79	MP0005464_abnormal_platelet_physiology	0.86093412
80	MP0005075_abnormal_melanosome_morpholog	0.85916946
81	MP0000358_abnormal_cell_content/	0.85209702
82	MP0005389_reproductive_system_phenotype	0.84432747
83	MP0002086_abnormal_extraembryonic_tissu	0.84160297
84	MP0009115_abnormal_fat_cell	0.83447637
85	MP0002084_abnormal_developmental_patter	0.83064283
86	MP0002693_abnormal_pancreas_physiology	0.79743380
87	MP0010234_abnormal_vibrissa_follicle	0.78205388
88	MP0000598_abnormal_liver_morphology	0.77228392
89	MP0000609_abnormal_liver_physiology	0.76239154
90	MP0001119_abnormal_female_reproductive	0.74672177
91	MP0002429_abnormal_blood_cell	0.74666266
92	MP0000689_abnormal_spleen_morphology	0.73789592
93	MP0005384_cellular_phenotype	0.73468621
94	MP0005408_hypopigmentation	0.72402758
95	MP0002006_tumorigenesis	0.70747029
96	MP0003959_abnormal_lean_body	0.69410483
97	MP0000685_abnormal_immune_system	0.68500146
98	MP0004381_abnormal_hair_follicle	0.66815776
99	MP0000371_diluted_coat_color	0.64106840
100	MP0009840_abnormal_foam_cell	0.63284098

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.18430430
2	Absent/shortened dynein arms (HP:0200106)	4.18430430
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.11086629
4	Abnormal gallbladder physiology (HP:0012438)	4.08758411
5	Cholecystitis (HP:0001082)	4.08758411
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.07078941
7	Chromsome breakage (HP:0040012)	4.06834809
8	Abnormal respiratory epithelium morphology (HP:0012253)	4.00263928
9	Abnormal respiratory motile cilium morphology (HP:0005938)	4.00263928
10	Abnormal ciliary motility (HP:0012262)	3.86949700
11	Abnormal respiratory motile cilium physiology (HP:0012261)	3.83710469
12	Truncus arteriosus (HP:0001660)	3.83233386
13	Reticulocytosis (HP:0001923)	3.73736305
14	Metaphyseal cupping (HP:0003021)	3.49800889
15	Rhinitis (HP:0012384)	3.47887488
16	Hyperthyroidism (HP:0000836)	3.46992992
17	Abnormality of reticulocytes (HP:0004312)	3.40626994
18	11 pairs of ribs (HP:0000878)	3.37189472
19	Atelectasis (HP:0100750)	3.28614648
20	Increased nuchal translucency (HP:0010880)	3.11379526
21	Abnormality of cochlea (HP:0000375)	3.09974130
22	Overlapping toe (HP:0001845)	3.08434975
23	Microvesicular hepatic steatosis (HP:0001414)	3.07580616
24	Nasal polyposis (HP:0100582)	2.91418691
25	Bronchiectasis (HP:0002110)	2.81861394
26	Type I transferrin isoform profile (HP:0003642)	2.71922231
27	Reticulocytopenia (HP:0001896)	2.70729558
28	Facial hemangioma (HP:0000329)	2.64079575
29	Thrombocytosis (HP:0001894)	2.62145358
30	Orthostatic hypotension (HP:0001278)	2.61116350
31	Seborrheic dermatitis (HP:0001051)	2.60868464
32	Chronic otitis media (HP:0000389)	2.43902487
33	Abnormal protein glycosylation (HP:0012346)	2.43662483
34	Abnormal glycosylation (HP:0012345)	2.43662483
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.43662483
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.43662483
37	Hypertensive crisis (HP:0100735)	2.38902673
38	Volvulus (HP:0002580)	2.38886592
39	Ankyloglossia (HP:0010296)	2.35842326
40	Abnormality of DNA repair (HP:0003254)	2.33696582
41	Poikiloderma (HP:0001029)	2.33203743
42	Broad distal phalanx of finger (HP:0009836)	2.33013226
43	Tubulointerstitial nephritis (HP:0001970)	2.32554269
44	Morphological abnormality of the inner ear (HP:0011390)	2.30865913
45	Abnormality of lateral ventricle (HP:0030047)	2.23261917
46	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.22616134
47	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.21447765
48	Chronic bronchitis (HP:0004469)	2.21418400
49	Bowel incontinence (HP:0002607)	2.19766948
50	Acute myeloid leukemia (HP:0004808)	2.19613380
51	Myelodysplasia (HP:0002863)	2.17230800
52	Squamous cell carcinoma (HP:0002860)	2.16712507
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.12566398
54	Hypoparathyroidism (HP:0000829)	2.12214280
55	Male infertility (HP:0003251)	2.12046989
56	Abnormality of the pancreatic islet cells (HP:0006476)	2.09235917
57	Abnormality of endocrine pancreas physiology (HP:0012093)	2.09235917
58	Abnormal large intestine physiology (HP:0012700)	2.06745243
59	Obsessive-compulsive behavior (HP:0000722)	2.06450022
60	Panhypogammaglobulinemia (HP:0003139)	2.06404950
61	Flattened epiphyses (HP:0003071)	2.04742881
62	Ectopic kidney (HP:0000086)	2.04610845
63	Duplicated collecting system (HP:0000081)	2.01950544
64	Polycystic kidney dysplasia (HP:0000113)	1.99881388
65	Poikilocytosis (HP:0004447)	1.96325420
66	Abnormality of the nasal mucosa (HP:0000433)	1.96253785
67	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.94277332
68	Absent epiphyses (HP:0010577)	1.94277332
69	Abnormal number of erythroid precursors (HP:0012131)	1.93800005
70	Basal cell carcinoma (HP:0002671)	1.92749863
71	Recurrent otitis media (HP:0000403)	1.92609950
72	Abnormality of chromosome segregation (HP:0002916)	1.92578827
73	Diaphragmatic weakness (HP:0009113)	1.91901523
74	Progressive muscle weakness (HP:0003323)	1.91464087
75	Sloping forehead (HP:0000340)	1.90592003
76	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.90135918
77	Abnormality of the preputium (HP:0100587)	1.88994655
78	Large hands (HP:0001176)	1.88652009
79	Cafe-au-lait spot (HP:0000957)	1.84616731
80	Recurrent sinusitis (HP:0011108)	1.83333365
81	Myopathic facies (HP:0002058)	1.83080755
82	Granulocytopenia (HP:0001913)	1.82658170
83	Gout (HP:0001997)	1.82185367
84	High pitched voice (HP:0001620)	1.81375942
85	Abnormality of the fingertips (HP:0001211)	1.78418433
86	Fatigue (HP:0012378)	1.77935401
87	Small intestinal stenosis (HP:0012848)	1.76678744
88	Duodenal stenosis (HP:0100867)	1.76678744
89	Abnormal gallbladder morphology (HP:0012437)	1.75054771
90	Abnormality of the gallbladder (HP:0005264)	1.74005092
91	Abnormality of chromosome stability (HP:0003220)	1.73755200
92	Hand muscle atrophy (HP:0009130)	1.72491281
93	Rhizomelia (HP:0008905)	1.72219134
94	Pallor (HP:0000980)	1.71688232
95	Cholelithiasis (HP:0001081)	1.71549414
96	Macroorchidism (HP:0000053)	1.70371978
97	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.70115301
98	Nephronophthisis (HP:0000090)	1.68230900
99	Absent thumb (HP:0009777)	1.65089173
100	Progressive external ophthalmoplegia (HP:0000590)	1.64775603

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.32272627
2	CDK8	2.90077099
3	TTK	2.79936178
4	EEF2K	2.75837046
5	WEE1	2.52433232
6	BMX	2.45474429
7	NEK2	2.18470566
8	MAP3K10	2.16663692
9	CDK12	2.15487798
10	ICK	2.12802415
11	MAPK15	2.10329763
12	MET	2.07259862
13	CDC7	2.04821226
14	SMG1	2.01650169
15	RIPK4	2.01372923
16	MAP3K2	1.96282526
17	TRIB3	1.87472476
18	EIF2AK1	1.76617507
19	PASK	1.76271112
20	KSR2	1.76096876
21	CAMK1G	1.53641758
22	RET	1.53260628
23	RPS6KB2	1.46954927
24	CDK4	1.46568653
25	ATR	1.46255201
26	PTK2B	1.45186504
27	CDK7	1.41347848
28	PLK4	1.39417771
29	MARK3	1.37153540
30	BUB1	1.35911870
31	MAP3K13	1.32619739
32	CHEK1	1.22820862
33	ERN1	1.19603854
34	FGFR3	1.18744486
35	CHEK2	1.18449923
36	BMPR1B	1.14700178
37	MAP3K8	1.13365425
38	CDK9	1.12400410
39	CDK6	1.11322142
40	EIF2AK3	1.08960635
41	FGFR4	1.08022693
42	NEK1	1.07340227
43	CLK1	1.04646018
44	BRSK2	1.03088181
45	NME2	1.00141960
46	FGFR2	0.99707705
47	MAP4K1	0.99251684
48	NME1	0.98432838
49	CSF1R	0.96812995
50	FGR	0.92802588
51	ATM	0.91804997
52	MST4	0.89705097
53	RAF1	0.89159508
54	MAP3K7	0.88832218
55	MKNK1	0.85235706
56	PRPF4B	0.83388507
57	PKN2	0.83162908
58	TGFBR1	0.81486314
59	MAPK11	0.80240859
60	STK10	0.79551312
61	PLK1	0.75234073
62	BRSK1	0.73943282
63	MST1R	0.73563697
64	KSR1	0.71983479
65	CDK2	0.70770260
66	CDK1	0.69641551
67	RPS6KA4	0.69055204
68	MAP2K3	0.68656700
69	MTOR	0.66672569
70	PRKCI	0.65477617
71	VRK1	0.64534218
72	CDK3	0.61791938
73	PLK3	0.60384755
74	BRD4	0.58469361
75	YES1	0.58235439
76	BTK	0.57204887
77	LRRK2	0.57033882
78	MAPKAPK5	0.56436661
79	MAPKAPK3	0.55821871
80	MAP2K6	0.52127743
81	CCNB1	0.52041092
82	SIK2	0.51453656
83	AURKB	0.51412001
84	NTRK3	0.50509872
85	SRPK1	0.50115903
86	ZAP70	0.49284551
87	TRPM7	0.49235385
88	TEC	0.48770135
89	MAP3K1	0.46498724
90	BRAF	0.45087826
91	PDPK1	0.42554000
92	RPS6KB1	0.42470144
93	TNK2	0.41245478
94	TYK2	0.40662856
95	TLK1	0.37076279
96	MAP4K2	0.36833927
97	AKT2	0.36612377
98	TYRO3	0.36275065
99	MAP3K6	0.35354350
100	WNK1	0.34586556

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.89502546
2	Mismatch repair_Homo sapiens_hsa03430	3.60053024
3	Homologous recombination_Homo sapiens_hsa03440	3.52077448
4	Base excision repair_Homo sapiens_hsa03410	3.17799920
5	Other glycan degradation_Homo sapiens_hsa00511	2.98691485
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.87115333
7	Nucleotide excision repair_Homo sapiens_hsa03420	2.85801615
8	One carbon pool by folate_Homo sapiens_hsa00670	2.58251501
9	Cell cycle_Homo sapiens_hsa04110	2.57104208
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.53396643
11	mRNA surveillance pathway_Homo sapiens_hsa03015	2.42049628
12	Pentose phosphate pathway_Homo sapiens_hsa00030	2.34376248
13	RNA transport_Homo sapiens_hsa03013	2.30900478
14	Spliceosome_Homo sapiens_hsa03040	2.09088895
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.92446888
16	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.75569294
17	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.72976011
18	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.61499543
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.59861909
20	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.57086974
21	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.40642357
22	RNA degradation_Homo sapiens_hsa03018	1.39507663
23	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.35297744
24	Lysine degradation_Homo sapiens_hsa00310	1.32166142
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.30952571
26	Non-small cell lung cancer_Homo sapiens_hsa05223	1.27048189
27	Acute myeloid leukemia_Homo sapiens_hsa05221	1.26818419
28	Ribosome_Homo sapiens_hsa03010	1.26166532
29	Oocyte meiosis_Homo sapiens_hsa04114	1.24599796
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.24290911
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.20362691
32	Carbon metabolism_Homo sapiens_hsa01200	1.18707307
33	VEGF signaling pathway_Homo sapiens_hsa04370	1.18147409
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.17694091
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.15453717
36	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.15076770
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05084783
38	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.03585581
39	mTOR signaling pathway_Homo sapiens_hsa04150	1.01495397
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.91762542
41	Arginine biosynthesis_Homo sapiens_hsa00220	0.91004637
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.87205679
43	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.86728795
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.83172019
45	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.80295257
46	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.78161101
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.75995175
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75359967
49	Pancreatic cancer_Homo sapiens_hsa05212	0.73199662
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73052850
51	Choline metabolism in cancer_Homo sapiens_hsa05231	0.72889423
52	Basal transcription factors_Homo sapiens_hsa03022	0.71391889
53	Viral carcinogenesis_Homo sapiens_hsa05203	0.67881920
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67653116
55	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66914463
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64938316
57	Purine metabolism_Homo sapiens_hsa00230	0.64541425
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.63524435
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.61851072
60	Insulin signaling pathway_Homo sapiens_hsa04910	0.61735582
61	Butanoate metabolism_Homo sapiens_hsa00650	0.59948553
62	Sulfur relay system_Homo sapiens_hsa04122	0.59178155
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.58408003
64	Prostate cancer_Homo sapiens_hsa05215	0.55702522
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55304515
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.54856567
67	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53375305
68	Herpes simplex infection_Homo sapiens_hsa05168	0.52462342
69	ErbB signaling pathway_Homo sapiens_hsa04012	0.52341770
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51952023
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.51073451
72	HTLV-I infection_Homo sapiens_hsa05166	0.49779028
73	Galactose metabolism_Homo sapiens_hsa00052	0.48987800
74	Small cell lung cancer_Homo sapiens_hsa05222	0.47985057
75	p53 signaling pathway_Homo sapiens_hsa04115	0.47671080
76	Hepatitis B_Homo sapiens_hsa05161	0.46357803
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.46020352
78	Fatty acid elongation_Homo sapiens_hsa00062	0.45625996
79	ABC transporters_Homo sapiens_hsa02010	0.43298859
80	Glutathione metabolism_Homo sapiens_hsa00480	0.43116779
81	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42433481
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.42395751
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.40965152
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.36783930
85	Glioma_Homo sapiens_hsa05214	0.34488802
86	Thyroid cancer_Homo sapiens_hsa05216	0.33670300
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.32479689
88	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.29326201
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27560536
90	Metabolic pathways_Homo sapiens_hsa01100	0.25592015
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.24924509
92	Influenza A_Homo sapiens_hsa05164	0.24708672
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24144729
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.23186052
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.22925553
96	Endometrial cancer_Homo sapiens_hsa05213	0.22456195
97	Prolactin signaling pathway_Homo sapiens_hsa04917	0.19753569
98	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.18103354
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.17263173
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.17177137

MSH5-SAPCD1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »