MSH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.61324513
2nuclear pore complex assembly (GO:0051292)5.45036699
3DNA unwinding involved in DNA replication (GO:0006268)5.27956882
4regulation of posttranscriptional gene silencing (GO:0060147)4.91693923
5regulation of gene silencing by miRNA (GO:0060964)4.91693923
6regulation of gene silencing by RNA (GO:0060966)4.91693923
7DNA replication initiation (GO:0006270)4.82133782
8DNA replication-dependent nucleosome assembly (GO:0006335)4.71029194
9DNA replication-dependent nucleosome organization (GO:0034723)4.71029194
10protein localization to kinetochore (GO:0034501)4.68352600
11folic acid-containing compound biosynthetic process (GO:0009396)4.51882985
12regulation of histone H3-K9 methylation (GO:0051570)4.41243371
13DNA strand elongation involved in DNA replication (GO:0006271)4.38402358
14mitotic nuclear envelope disassembly (GO:0007077)4.36340432
15IMP biosynthetic process (GO:0006188)4.30676612
16nucleobase biosynthetic process (GO:0046112)4.19658207
17negative regulation of histone methylation (GO:0031061)4.19119988
18DNA strand elongation (GO:0022616)4.15342383
19pore complex assembly (GO:0046931)4.12669034
20membrane disassembly (GO:0030397)4.08341023
21nuclear envelope disassembly (GO:0051081)4.08341023
22DNA geometric change (GO:0032392)4.07790176
23DNA duplex unwinding (GO:0032508)4.07429676
24mitotic metaphase plate congression (GO:0007080)4.06511483
25heterochromatin organization (GO:0070828)3.91632628
26protein localization to chromosome, centromeric region (GO:0071459)3.84510679
27purine nucleobase biosynthetic process (GO:0009113)3.83366213
28IMP metabolic process (GO:0046040)3.82764138
29formation of translation preinitiation complex (GO:0001731)3.80294532
30telomere maintenance via semi-conservative replication (GO:0032201)3.79593261
31pre-miRNA processing (GO:0031054)3.79462587
32mitotic sister chromatid segregation (GO:0000070)3.78209881
33ribosome assembly (GO:0042255)3.77957551
34DNA replication checkpoint (GO:0000076)3.76385163
35double-strand break repair via nonhomologous end joining (GO:0006303)3.71575110
36non-recombinational repair (GO:0000726)3.71575110
37metaphase plate congression (GO:0051310)3.67663983
38mitotic chromosome condensation (GO:0007076)3.66320452
39sister chromatid segregation (GO:0000819)3.64603379
40protein K6-linked ubiquitination (GO:0085020)3.60437880
41regulation of translational fidelity (GO:0006450)3.59950111
42DNA ligation (GO:0006266)3.58581716
43DNA topological change (GO:0006265)3.57608755
44positive regulation of chromosome segregation (GO:0051984)3.55124186
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54153103
46protein complex localization (GO:0031503)3.50280409
47chromatin remodeling at centromere (GO:0031055)3.49546215
48regulation of spindle organization (GO:0090224)3.46660198
49DNA damage response, detection of DNA damage (GO:0042769)3.46579079
50mitotic recombination (GO:0006312)3.45795046
51maturation of SSU-rRNA (GO:0030490)3.43964696
52telomere maintenance via recombination (GO:0000722)3.43246175
53mitotic sister chromatid cohesion (GO:0007064)3.43000795
54chromatin assembly (GO:0031497)3.41041219
55DNA synthesis involved in DNA repair (GO:0000731)3.38922369
56kinetochore organization (GO:0051383)3.37644244
57regulation of gene silencing (GO:0060968)3.37000928
58ATP-dependent chromatin remodeling (GO:0043044)3.31984369
59regulation of centrosome cycle (GO:0046605)3.31675751
60ribosome biogenesis (GO:0042254)3.30314012
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29434929
62telomere maintenance via telomere lengthening (GO:0010833)3.28812179
63regulation of mitotic spindle organization (GO:0060236)3.28594855
64dosage compensation (GO:0007549)3.27838743
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27374053
66histone H2A monoubiquitination (GO:0035518)3.27180453
67DNA replication-independent nucleosome organization (GO:0034724)3.26703714
68DNA replication-independent nucleosome assembly (GO:0006336)3.26703714
69regulation of DNA endoreduplication (GO:0032875)3.25860878
70regulation of centrosome duplication (GO:0010824)3.24876900
71CENP-A containing nucleosome assembly (GO:0034080)3.24786132
72regulation of sister chromatid cohesion (GO:0007063)3.24625381
73attachment of spindle microtubules to kinetochore (GO:0008608)3.24586568
74DNA double-strand break processing (GO:0000729)3.23712095
75mitotic spindle checkpoint (GO:0071174)3.23404523
76establishment of chromosome localization (GO:0051303)3.21805774
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20927653
78regulation of centriole replication (GO:0046599)3.20800693
79chromatin assembly or disassembly (GO:0006333)3.19495995
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.19041056
81regulation of translational termination (GO:0006449)3.18503151
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18286593
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18286593
84positive regulation of mitotic sister chromatid separation (GO:1901970)3.18286593
85DNA conformation change (GO:0071103)3.18261447
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15407675
87negative regulation of mRNA processing (GO:0050686)3.15218235
88regulation of chromosome segregation (GO:0051983)3.14593133
89nuclear envelope organization (GO:0006998)3.13087414
90negative regulation of DNA-dependent DNA replication (GO:2000104)3.12943871
91mitotic spindle assembly checkpoint (GO:0007094)3.12817577
92positive regulation of SMAD protein import into nucleus (GO:0060391)3.11977348
93paraxial mesoderm development (GO:0048339)3.11651854
94regulation of mitotic sister chromatid separation (GO:0010965)3.09637616
95regulation of mitotic sister chromatid segregation (GO:0033047)3.09637616
96regulation of sister chromatid segregation (GO:0033045)3.09637616
97negative regulation of chromosome segregation (GO:0051985)3.08233432
98kinetochore assembly (GO:0051382)3.07456915
99* somatic hypermutation of immunoglobulin genes (GO:0016446)3.05865718
100* somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05865718
101chaperone-mediated protein complex assembly (GO:0051131)3.03425042
102establishment of viral latency (GO:0019043)3.03233142
103L-serine metabolic process (GO:0006563)3.02606419
104negative regulation of mRNA metabolic process (GO:1903312)3.02563679
105histone exchange (GO:0043486)3.00972315
106regulation of nuclear cell cycle DNA replication (GO:0033262)3.00684696
107protein localization to chromosome (GO:0034502)3.00446252
108regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99876576
109sister chromatid cohesion (GO:0007062)2.99495940
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99430171
111histone H4-K12 acetylation (GO:0043983)2.99386145
112ribonucleoprotein complex biogenesis (GO:0022613)2.99077923
113spindle checkpoint (GO:0031577)2.98888026
114regulation of RNA export from nucleus (GO:0046831)2.98714589
115meiotic chromosome segregation (GO:0045132)2.98467565
116negative regulation of sister chromatid segregation (GO:0033046)2.98227263
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.98227263
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98227263
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98227263
120regulation of telomere maintenance via telomerase (GO:0032210)2.97497590
121DNA strand renaturation (GO:0000733)2.97347607
122ribosomal large subunit biogenesis (GO:0042273)2.96626280
123spindle assembly checkpoint (GO:0071173)2.96562853
124postreplication repair (GO:0006301)2.96382148
125telomere maintenance (GO:0000723)2.96248030
126intra-S DNA damage checkpoint (GO:0031573)2.96221742
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95441475
128negative regulation of DNA repair (GO:0045738)2.94405995
129establishment of integrated proviral latency (GO:0075713)2.94223979
130telomere organization (GO:0032200)2.93599448
131negative regulation of RNA splicing (GO:0033119)2.93336049
132replication fork processing (GO:0031297)2.88616353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human9.66791799
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.51391038
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02333640
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86135770
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12689131
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03624788
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89935035
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70829359
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.59490212
10* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51901423
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47201926
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40744713
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40744713
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40744713
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35377643
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33384175
17* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.28417564
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.25874214
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16577445
20AR_21909140_ChIP-Seq_LNCAP_Human2.10296704
21* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08946992
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06929399
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.05804894
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03840986
25* E2F1_21310950_ChIP-Seq_MCF-7_Human2.03532704
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03491309
27XRN2_22483619_ChIP-Seq_HELA_Human1.99563218
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94831354
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.92596334
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87837805
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83721171
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82619933
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81846294
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80692980
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75587159
36* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73587674
37* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72681688
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70287298
39* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69524438
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69174130
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68278039
42MYC_22102868_ChIP-Seq_BL_Human1.66993285
43* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66325129
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.65864434
45VDR_23849224_ChIP-Seq_CD4+_Human1.62256538
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60794473
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55513292
48* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50393009
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48692806
50FOXP3_21729870_ChIP-Seq_TREG_Human1.48560746
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.46926340
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46044213
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44368115
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44329684
55* TTF2_22483619_ChIP-Seq_HELA_Human1.43983866
56EWS_26573619_Chip-Seq_HEK293_Human1.43271425
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41699019
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41634395
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39019127
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.38640150
61* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37920127
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37396813
63MYC_18940864_ChIP-ChIP_HL60_Human1.36468311
64DCP1A_22483619_ChIP-Seq_HELA_Human1.36268998
65* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.35442718
66KDM5A_27292631_Chip-Seq_BREAST_Human1.35323634
67* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35245157
68CIITA_25753668_ChIP-Seq_RAJI_Human1.33833450
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32470044
70* GABP_19822575_ChIP-Seq_HepG2_Human1.32090456
71* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28359254
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25861813
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25251049
74ELK1_19687146_ChIP-ChIP_HELA_Human1.23921042
75* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23694885
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.21414439
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.21030526
78FUS_26573619_Chip-Seq_HEK293_Human1.19662900
79IRF1_19129219_ChIP-ChIP_H3396_Human1.17279685
80* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17072859
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15036962
82TFEB_21752829_ChIP-Seq_HELA_Human1.14627527
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14139612
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13838265
85* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13531382
86* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09448711
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.08039799
88* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07996612
89* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07876638
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07208014
91* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06473564
92POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02622604
93* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02301254
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01097410
95* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99703129
96* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98972305
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98603551
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97374053
99* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97310491
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97264179
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97097875
102* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97058965
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96536669
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95489421
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95340800
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95221667
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93723236
108ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93463041
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92859681
110* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92836306
111* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91127124
112ZNF274_21170338_ChIP-Seq_K562_Hela0.90205506
113IGF1R_20145208_ChIP-Seq_DFB_Human0.88426360
114* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86591089
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84638237
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.83742306
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80977419
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79037563
119TAF15_26573619_Chip-Seq_HEK293_Human0.77286244
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75630554
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.74025441
122* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71133488
123SOX9_26525672_Chip-Seq_HEART_Mouse0.71106017
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70280004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.81072680
2MP0003693_abnormal_embryo_hatching4.40660168
3MP0008057_abnormal_DNA_replication4.37717109
4MP0003111_abnormal_nucleus_morphology4.37224411
5MP0004957_abnormal_blastocyst_morpholog4.27332396
6MP0003077_abnormal_cell_cycle3.87135569
7MP0010352_gastrointestinal_tract_polyps3.19259520
8MP0008058_abnormal_DNA_repair3.15166539
9MP0001730_embryonic_growth_arrest2.66111014
10MP0010307_abnormal_tumor_latency2.63634858
11MP0003123_paternal_imprinting2.55350126
12MP0000350_abnormal_cell_proliferation2.54154919
13MP0008007_abnormal_cellular_replicative2.41474359
14MP0008932_abnormal_embryonic_tissue2.35095451
15MP0008877_abnormal_DNA_methylation2.28156238
16MP0003806_abnormal_nucleotide_metabolis2.21427744
17MP0005380_embryogenesis_phenotype2.09181230
18MP0001672_abnormal_embryogenesis/_devel2.09181230
19MP0002084_abnormal_developmental_patter2.08518687
20MP0002085_abnormal_embryonic_tissue1.99820843
21MP0001697_abnormal_embryo_size1.97831719
22MP0009697_abnormal_copulation1.94930263
23MP0004197_abnormal_fetal_growth/weight/1.94172845
24MP0005076_abnormal_cell_differentiation1.93287359
25MP0002086_abnormal_extraembryonic_tissu1.85487274
26MP0003984_embryonic_growth_retardation1.83529713
27MP0003705_abnormal_hypodermis_morpholog1.82910518
28MP0002088_abnormal_embryonic_growth/wei1.80474191
29MP0002080_prenatal_lethality1.74557544
30MP0003786_premature_aging1.74235939
31MP0003890_abnormal_embryonic-extraembry1.72272966
32MP0002653_abnormal_ependyma_morphology1.69303957
33MP0001293_anophthalmia1.63735538
34MP0003121_genomic_imprinting1.63649493
35MP0002396_abnormal_hematopoietic_system1.61529572
36MP0004133_heterotaxia1.61244402
37MP0003567_abnormal_fetal_cardiomyocyte1.50330532
38MP0004147_increased_porphyrin_level1.47111771
39MP0000490_abnormal_crypts_of1.46217606
40MP0003119_abnormal_digestive_system1.44821947
41MP0000537_abnormal_urethra_morphology1.42548151
42MP0000313_abnormal_cell_death1.35643128
43MP0010234_abnormal_vibrissa_follicle1.34966646
44MP0003718_maternal_effect1.32814593
45MP0002938_white_spotting1.30048960
46MP0003941_abnormal_skin_development1.29895906
47MP0002233_abnormal_nose_morphology1.27292867
48MP0003566_abnormal_cell_adhesion1.26589621
49MP0010030_abnormal_orbit_morphology1.25333300
50MP0002210_abnormal_sex_determination1.24783104
51* MP0002019_abnormal_tumor_incidence1.23979601
52MP0000566_synostosis1.22348691
53MP0001145_abnormal_male_reproductive1.15238814
54MP0002009_preneoplasia1.14203848
55MP0004264_abnormal_extraembryonic_tissu1.12866507
56MP0001849_ear_inflammation1.12555429
57MP0003283_abnormal_digestive_organ1.09748822
58MP0009053_abnormal_anal_canal1.07424516
59MP0004808_abnormal_hematopoietic_stem1.06956215
60MP0008995_early_reproductive_senescence1.06737317
61MP0006072_abnormal_retinal_apoptosis1.03277109
62MP0003937_abnormal_limbs/digits/tail_de1.03266162
63MP0002111_abnormal_tail_morphology1.02979567
64MP0009703_decreased_birth_body1.02449907
65MP0009672_abnormal_birth_weight0.97669508
66MP0001929_abnormal_gametogenesis0.96265640
67MP0005023_abnormal_wound_healing0.96140540
68MP0001915_intracranial_hemorrhage0.95049895
69MP0000049_abnormal_middle_ear0.94103300
70MP0000653_abnormal_sex_gland0.93583788
71MP0002877_abnormal_melanocyte_morpholog0.93418400
72MP0003943_abnormal_hepatobiliary_system0.93402191
73MP0003385_abnormal_body_wall0.92798082
74MP0002092_abnormal_eye_morphology0.92303384
75MP0002751_abnormal_autonomic_nervous0.92067993
76MP0001299_abnormal_eye_distance/0.90027253
77MP0003136_yellow_coat_color0.89827050
78MP0005394_taste/olfaction_phenotype0.89287811
79MP0005499_abnormal_olfactory_system0.89287811
80MP0001286_abnormal_eye_development0.88631697
81MP0003755_abnormal_palate_morphology0.88258378
82MP0001346_abnormal_lacrimal_gland0.87455873
83MP0003122_maternal_imprinting0.86591065
84MP0002697_abnormal_eye_size0.86580712
85MP0006292_abnormal_olfactory_placode0.85298319
86MP0005384_cellular_phenotype0.83799381
87MP0005621_abnormal_cell_physiology0.83137006
88MP0003221_abnormal_cardiomyocyte_apopto0.82145621
89MP0001529_abnormal_vocalization0.81843133
90MP0000703_abnormal_thymus_morphology0.81420572
91MP0003315_abnormal_perineum_morphology0.81346816
92MP0003115_abnormal_respiratory_system0.80953865
93MP0001661_extended_life_span0.80756833
94MP0005397_hematopoietic_system_phenotyp0.80520097
95MP0001545_abnormal_hematopoietic_system0.80520097
96MP0000428_abnormal_craniofacial_morphol0.79958575
97MP0003861_abnormal_nervous_system0.79501562
98MP0002254_reproductive_system_inflammat0.78982423
99MP0005187_abnormal_penis_morphology0.78830845
100MP0002102_abnormal_ear_morphology0.78767331
101MP0009278_abnormal_bone_marrow0.78583895
102MP0003942_abnormal_urinary_system0.78043655
103MP0000432_abnormal_head_morphology0.77444533
104MP0000647_abnormal_sebaceous_gland0.77101523
105MP0000358_abnormal_cell_content/0.74439163
106MP0002160_abnormal_reproductive_system0.74336013
107MP0000477_abnormal_intestine_morphology0.74085958
108MP0005391_vision/eye_phenotype0.73930632
109MP0008789_abnormal_olfactory_epithelium0.73570320
110MP0003698_abnormal_male_reproductive0.73493201
111MP0005266_abnormal_metabolism0.71906402
112MP0002081_perinatal_lethality0.71764113
113MP0002925_abnormal_cardiovascular_devel0.71277649
114MP0002075_abnormal_coat/hair_pigmentati0.70351458
115MP0008770_decreased_survivor_rate0.69887979
116MP0003787_abnormal_imprinting0.68981475
117MP0000371_diluted_coat_color0.67685875
118MP0000516_abnormal_urinary_system0.67160753
119MP0005367_renal/urinary_system_phenotyp0.67160753
120MP0006035_abnormal_mitochondrial_morpho0.66819515
121MP0001188_hyperpigmentation0.65944421
122MP0005501_abnormal_skin_physiology0.65429083
123MP0000631_abnormal_neuroendocrine_gland0.65282622
124MP0003699_abnormal_female_reproductive0.64318649
125MP0001119_abnormal_female_reproductive0.63889110
126MP0005623_abnormal_meninges_morphology0.63581714
127MP0004185_abnormal_adipocyte_glucose0.63422970
128MP0005389_reproductive_system_phenotype0.63051822
129MP0003936_abnormal_reproductive_system0.61878017
130MP0003935_abnormal_craniofacial_develop0.61324583
131MP0000733_abnormal_muscle_development0.59934256
132MP0002722_abnormal_immune_system0.58235506
133MP0000858_altered_metastatic_potential0.56939677
134MP0004233_abnormal_muscle_weight0.54991597
135MP0002114_abnormal_axial_skeleton0.52001508

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.31002602
2Birth length less than 3rd percentile (HP:0003561)4.26037899
3Chromsome breakage (HP:0040012)4.18631931
4Colon cancer (HP:0003003)4.12698007
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89707711
6* Ependymoma (HP:0002888)3.87077509
7Selective tooth agenesis (HP:0001592)3.78133362
8Breast hypoplasia (HP:0003187)3.51473519
9Abnormality of chromosome stability (HP:0003220)3.44449126
10Supernumerary spleens (HP:0009799)3.28664576
11Reticulocytopenia (HP:0001896)3.25225300
12Absent radius (HP:0003974)3.22790161
13* Medulloblastoma (HP:0002885)3.20936680
14Embryonal renal neoplasm (HP:0011794)3.19943045
15Impulsivity (HP:0100710)3.12704785
16Patellar aplasia (HP:0006443)3.05797118
17Absent forearm bone (HP:0003953)3.01788076
18Aplasia involving forearm bones (HP:0009822)3.01788076
19Proximal placement of thumb (HP:0009623)2.95292185
20Meckel diverticulum (HP:0002245)2.95182577
21Missing ribs (HP:0000921)2.91751069
22Cortical dysplasia (HP:0002539)2.88270383
23Deviation of the thumb (HP:0009603)2.87837448
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.85749578
25Abnormality of the ileum (HP:0001549)2.85153080
26Abnormality of the preputium (HP:0100587)2.80829414
27Aplasia/Hypoplasia of the patella (HP:0006498)2.80212421
28Abnormal number of incisors (HP:0011064)2.78380511
29Absent thumb (HP:0009777)2.78303036
30Volvulus (HP:0002580)2.75346938
31Aplasia/hypoplasia of the humerus (HP:0006507)2.71846509
32Abnormality of the anterior horn cell (HP:0006802)2.71629434
33Degeneration of anterior horn cells (HP:0002398)2.71629434
34Esophageal atresia (HP:0002032)2.70908537
35* Neoplasm of the oral cavity (HP:0100649)2.69199165
36* Abnormality of the astrocytes (HP:0100707)2.66330883
37* Astrocytoma (HP:0009592)2.66330883
38Rib fusion (HP:0000902)2.62708868
39Oral leukoplakia (HP:0002745)2.62236958
40Carpal bone hypoplasia (HP:0001498)2.61858417
41Increased nuchal translucency (HP:0010880)2.56259996
42* Rhabdomyosarcoma (HP:0002859)2.55705379
43Short humerus (HP:0005792)2.55458166
44Abnormality of abdominal situs (HP:0011620)2.54521449
45Abdominal situs inversus (HP:0003363)2.54521449
46Myelodysplasia (HP:0002863)2.54497421
47Small intestinal stenosis (HP:0012848)2.52721800
48Duodenal stenosis (HP:0100867)2.52721800
49Ectopic kidney (HP:0000086)2.39222676
50* Glioma (HP:0009733)2.33748573
51Sloping forehead (HP:0000340)2.31719639
52Facial hemangioma (HP:0000329)2.30431279
53Shawl scrotum (HP:0000049)2.30262224
54Atresia of the external auditory canal (HP:0000413)2.26948940
55Prominent nose (HP:0000448)2.24732487
5611 pairs of ribs (HP:0000878)2.23928929
57Abnormality of the duodenum (HP:0002246)2.21704749
58Clubbing of toes (HP:0100760)2.21295449
59* Neoplasm of striated muscle (HP:0009728)2.21213549
60Tracheoesophageal fistula (HP:0002575)2.19964253
61Aplasia/Hypoplasia of the sternum (HP:0006714)2.19801351
62Abnormality of the carotid arteries (HP:0005344)2.16218976
63* Cafe-au-lait spot (HP:0000957)2.15928752
64* Neoplasm of the pancreas (HP:0002894)2.15361081
65* Basal cell carcinoma (HP:0002671)2.14730744
66Squamous cell carcinoma (HP:0002860)2.14312909
67Supernumerary bones of the axial skeleton (HP:0009144)2.13082067
68Supernumerary ribs (HP:0005815)2.11770348
69Rough bone trabeculation (HP:0100670)2.10546361
70Spinal muscular atrophy (HP:0007269)2.04998041
71Horseshoe kidney (HP:0000085)2.04816552
72Embryonal neoplasm (HP:0002898)2.02889714
73Stenosis of the external auditory canal (HP:0000402)2.02513613
74Choanal atresia (HP:0000453)2.02459271
75Intestinal atresia (HP:0011100)2.01318619
76Bone marrow hypocellularity (HP:0005528)2.01115959
77Asplenia (HP:0001746)2.00758930
78Gastrointestinal atresia (HP:0002589)2.00565379
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00282678
80Duplicated collecting system (HP:0000081)1.99988043
81Facial cleft (HP:0002006)1.99825783
82Sandal gap (HP:0001852)1.99433549
83Hepatoblastoma (HP:0002884)1.98905129
84Short thumb (HP:0009778)1.97610260
85High anterior hairline (HP:0009890)1.96117832
86Abnormality of cells of the erythroid lineage (HP:0012130)1.96058343
87Shoulder girdle muscle weakness (HP:0003547)1.95287278
88Multiple enchondromatosis (HP:0005701)1.94870141
89Duplication of thumb phalanx (HP:0009942)1.94483389
90Vertebral clefting (HP:0008428)1.92851101
91* Agnosia (HP:0010524)1.92068683
92Spastic diplegia (HP:0001264)1.91896051
93Abnormality of cochlea (HP:0000375)1.91823347
94Abnormality of the lower motor neuron (HP:0002366)1.91617741
95* Biliary tract neoplasm (HP:0100574)1.90751775
96Rectovaginal fistula (HP:0000143)1.90559459
97Rectal fistula (HP:0100590)1.90559459
98Premature graying of hair (HP:0002216)1.90213989
99Skull defect (HP:0001362)1.89990462
100Pseudobulbar signs (HP:0002200)1.89684930
101Nephroblastoma (Wilms tumor) (HP:0002667)1.88373563
102* Ovarian neoplasm (HP:0100615)1.86296254
103Trismus (HP:0000211)1.86247415
104Abnormality of the septum pellucidum (HP:0007375)1.86172267
105Cerebral hypomyelination (HP:0006808)1.85820548
106Hemivertebrae (HP:0002937)1.84966446
107Premature ovarian failure (HP:0008209)1.84177285
108Abnormal lung lobation (HP:0002101)1.83990554
109Triphalangeal thumb (HP:0001199)1.83895489
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.83109306
111Sparse lateral eyebrow (HP:0005338)1.81947650
112High pitched voice (HP:0001620)1.81662116
113Short 4th metacarpal (HP:0010044)1.81147798
114Arteriovenous malformation (HP:0100026)1.74165947
115Dandy-Walker malformation (HP:0001305)1.72430529
116Abnormality of DNA repair (HP:0003254)1.70918104
117Preaxial hand polydactyly (HP:0001177)1.70889625
118* Neoplasm of the colon (HP:0100273)1.70868261
119Bifid tongue (HP:0010297)1.70532373
120Obsessive-compulsive behavior (HP:0000722)1.68505427
121Neoplasm of the adrenal cortex (HP:0100641)1.68141199
122Irregular epiphyses (HP:0010582)1.64831515
123Breast carcinoma (HP:0003002)1.63414305
124Absent septum pellucidum (HP:0001331)1.59893682
125Deep philtrum (HP:0002002)1.59855129
126Anal stenosis (HP:0002025)1.59075283
127Hypoplasia of the pons (HP:0012110)1.58983721
128Abnormality of chromosome segregation (HP:0002916)1.58295684
129Bilateral microphthalmos (HP:0007633)1.57357504
130* Gastrointestinal carcinoma (HP:0002672)1.56757583
131* Malignant gastrointestinal tract tumors (HP:0006749)1.56757583
132Cerebellar dysplasia (HP:0007033)1.56659096
133Sex reversal (HP:0012245)1.55759153
134Abnormal sex determination (HP:0012244)1.55759153
135Microvesicular hepatic steatosis (HP:0001414)1.54956818
136Partial agenesis of the corpus callosum (HP:0001338)1.54634713
137Septo-optic dysplasia (HP:0100842)1.54609569
138Overlapping toe (HP:0001845)1.53788237
139Aqueductal stenosis (HP:0002410)1.53590102
140Short tibia (HP:0005736)1.51494200
141Generalized hypotonia (HP:0001290)1.50775546
142Broad thumb (HP:0011304)1.50019400
143Abnormality of the pons (HP:0007361)1.49890915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.53207720
2WEE14.26790048
3CDK123.76544667
4BUB13.09298980
5TTK2.90687434
6EPHA22.87341844
7NEK22.81022463
8NEK12.74113002
9RPS6KB22.57136963
10TSSK62.45832367
11EEF2K2.42997271
12SRPK12.23469395
13PASK2.11679281
14PLK11.98961946
15PNCK1.97174276
16EIF2AK11.91298986
17CDK71.86418481
18ATR1.85986189
19MAP4K21.82946383
20ACVR1B1.80267633
21TAF11.75096529
22CHEK21.66926860
23SCYL21.65350342
24BRD41.64371177
25TRIM281.62819381
26PLK31.59467362
27AURKB1.57265406
28CDK41.56342708
29TLK11.56339825
30CHEK11.54136709
31PKN21.53688478
32MKNK11.46002483
33MAP3K81.42712445
34DYRK31.40793627
35BRSK21.39057698
36FLT31.38915297
37ALK1.32624998
38STK101.26978263
39BCR1.25471786
40STK41.22090570
41ATM1.21902263
42TGFBR11.20947582
43AURKA1.17039332
44MKNK21.15043029
45PAK41.14988804
46TESK21.14814434
47MAP3K101.13835625
48VRK21.13155709
49EIF2AK31.09904626
50PLK41.09760196
51* CDK21.08121799
52VRK11.07026503
53CDK61.02561015
54MAPKAPK30.99922813
55SMG10.96746317
56PIM10.94438003
57TNIK0.93744429
58LATS10.91417572
59MTOR0.89891405
60EIF2AK20.88745381
61RPS6KA40.87951336
62ZAK0.87020437
63MELK0.86522265
64CAMK1G0.85664315
65AKT30.85313378
66NUAK10.81018708
67STK30.80324283
68CDK10.78488639
69FGFR20.78260505
70CSNK1G10.77280312
71LATS20.76306221
72CLK10.75291048
73PRKCI0.73225463
74WNK30.71322139
75MAP3K40.71030155
76BRSK10.70567456
77BMPR1B0.69510059
78* CSNK2A20.68702952
79NME20.68643938
80CAMK1D0.64776764
81MET0.64405318
82STK38L0.63975910
83CSNK1E0.63043111
84CDK190.58316479
85PRKDC0.57614699
86* CSNK1D0.57527655
87ERBB30.56468307
88CCNB10.54605986
89PLK20.52659226
90FGFR10.52437234
91ICK0.51937901
92PDK40.50751516
93PDK30.50751516
94PAK10.50343202
95CSNK1G30.49610816
96CSNK2A10.49587528
97CDK80.48988555
98CDK30.48532175
99CSNK1A1L0.48203732
100AKT20.46401728
101LRRK20.43199645
102CSNK1G20.41428822
103RPS6KA50.40937351
104* MAPK140.40693101
105PAK20.40047072
106CDK180.38881570
107CDK90.35875011
108PDK20.35575403
109MAPK10.35209534
110STK160.34582327
111GRK60.33814920
112CDK150.33597596
113CASK0.32433035
114AKT10.32346706
115* GSK3B0.32106370
116CDK11A0.31936742
117ERBB40.31752904
118RAF10.31629707
119RPS6KB10.28979854
120TYRO30.25684913
121YES10.25632008
122BMX0.22619284
123TTN0.21820164
124RPS6KA10.21075189
125PDGFRA0.20819557
126BRAF0.20773919
127PBK0.20061172
128MAPK100.19254808
129MST40.18845013
130DYRK20.15148258
131KSR10.14853113
132MAP2K30.12772127

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95805400
2* Mismatch repair_Homo sapiens_hsa034304.27142388
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.96619604
4RNA transport_Homo sapiens_hsa030133.51286850
5One carbon pool by folate_Homo sapiens_hsa006703.36315904
6Spliceosome_Homo sapiens_hsa030403.34778018
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.06105176
8Cell cycle_Homo sapiens_hsa041102.95727856
9Nucleotide excision repair_Homo sapiens_hsa034202.91575856
10Homologous recombination_Homo sapiens_hsa034402.91185630
11Base excision repair_Homo sapiens_hsa034102.86575837
12Non-homologous end-joining_Homo sapiens_hsa034502.54091255
13RNA polymerase_Homo sapiens_hsa030202.51112976
14Fanconi anemia pathway_Homo sapiens_hsa034602.48679875
15Ribosome_Homo sapiens_hsa030102.37212679
16mRNA surveillance pathway_Homo sapiens_hsa030152.15944413
17RNA degradation_Homo sapiens_hsa030181.93552058
18Pyrimidine metabolism_Homo sapiens_hsa002401.90872734
19Proteasome_Homo sapiens_hsa030501.87330893
20Systemic lupus erythematosus_Homo sapiens_hsa053221.81384433
21Basal transcription factors_Homo sapiens_hsa030221.75053228
22p53 signaling pathway_Homo sapiens_hsa041151.73252716
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42163152
24Pyruvate metabolism_Homo sapiens_hsa006201.32981844
25Viral carcinogenesis_Homo sapiens_hsa052031.30238155
26Steroid biosynthesis_Homo sapiens_hsa001001.29674632
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23805129
28Propanoate metabolism_Homo sapiens_hsa006401.15805940
29Biosynthesis of amino acids_Homo sapiens_hsa012301.11572227
30Selenocompound metabolism_Homo sapiens_hsa004501.11336440
31Oocyte meiosis_Homo sapiens_hsa041141.11065451
32Epstein-Barr virus infection_Homo sapiens_hsa051691.09707330
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08504929
34MicroRNAs in cancer_Homo sapiens_hsa052061.04722797
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02234761
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01984640
37Antigen processing and presentation_Homo sapiens_hsa046120.94068471
38Purine metabolism_Homo sapiens_hsa002300.93735086
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.90570527
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89153462
41Protein export_Homo sapiens_hsa030600.88956235
42Hippo signaling pathway_Homo sapiens_hsa043900.87900730
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86017580
44Basal cell carcinoma_Homo sapiens_hsa052170.85859306
45HTLV-I infection_Homo sapiens_hsa051660.83785471
46Herpes simplex infection_Homo sapiens_hsa051680.83425032
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.83221569
48Thyroid cancer_Homo sapiens_hsa052160.82793123
49Alcoholism_Homo sapiens_hsa050340.80097952
50Pentose phosphate pathway_Homo sapiens_hsa000300.72914027
51TGF-beta signaling pathway_Homo sapiens_hsa043500.72153251
52Notch signaling pathway_Homo sapiens_hsa043300.69270552
53Small cell lung cancer_Homo sapiens_hsa052220.69211114
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68620109
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66402240
56Adherens junction_Homo sapiens_hsa045200.64874376
57mTOR signaling pathway_Homo sapiens_hsa041500.62914040
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61440783
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.61307650
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.60623423
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59790737
62Folate biosynthesis_Homo sapiens_hsa007900.56125039
63Carbon metabolism_Homo sapiens_hsa012000.54894470
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54421489
65N-Glycan biosynthesis_Homo sapiens_hsa005100.54066738
66Lysine degradation_Homo sapiens_hsa003100.53080656
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52500489
68Hedgehog signaling pathway_Homo sapiens_hsa043400.51645751
69Fatty acid elongation_Homo sapiens_hsa000620.50989664
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50240591
71Nicotine addiction_Homo sapiens_hsa050330.49876105
72Bladder cancer_Homo sapiens_hsa052190.48563665
73Tight junction_Homo sapiens_hsa045300.44904937
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44281909
75* Colorectal cancer_Homo sapiens_hsa052100.43585932
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43105549
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42898826
78Chronic myeloid leukemia_Homo sapiens_hsa052200.41048692
79Fructose and mannose metabolism_Homo sapiens_hsa000510.40676423
80* Pathways in cancer_Homo sapiens_hsa052000.39038101
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38885290
82Legionellosis_Homo sapiens_hsa051340.38460101
83Apoptosis_Homo sapiens_hsa042100.37489105
84Fatty acid metabolism_Homo sapiens_hsa012120.37055752
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36633938
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36107534
87HIF-1 signaling pathway_Homo sapiens_hsa040660.35092620
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33733676
89Prostate cancer_Homo sapiens_hsa052150.33284832
90Glutathione metabolism_Homo sapiens_hsa004800.32950991
91Taste transduction_Homo sapiens_hsa047420.32609756
92Huntingtons disease_Homo sapiens_hsa050160.32283943
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31884352
94Wnt signaling pathway_Homo sapiens_hsa043100.31746076
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30915644
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30796330
97Axon guidance_Homo sapiens_hsa043600.29745647
98Metabolic pathways_Homo sapiens_hsa011000.26899842
99Phototransduction_Homo sapiens_hsa047440.26397540
100ErbB signaling pathway_Homo sapiens_hsa040120.26272052
101Proteoglycans in cancer_Homo sapiens_hsa052050.26157212
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25818956
103Hepatitis B_Homo sapiens_hsa051610.24580316
104Non-small cell lung cancer_Homo sapiens_hsa052230.24148286
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24094762
106Endometrial cancer_Homo sapiens_hsa052130.23284403
107Melanoma_Homo sapiens_hsa052180.21557600
108Renal cell carcinoma_Homo sapiens_hsa052110.20206578
109Viral myocarditis_Homo sapiens_hsa054160.19636437
110Acute myeloid leukemia_Homo sapiens_hsa052210.18788830
111Sulfur relay system_Homo sapiens_hsa041220.16879537
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16457736
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15895131
114Vitamin B6 metabolism_Homo sapiens_hsa007500.15891126
115FoxO signaling pathway_Homo sapiens_hsa040680.14862684
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13265484
117Galactose metabolism_Homo sapiens_hsa000520.11982147
118Butanoate metabolism_Homo sapiens_hsa006500.11859125
119Influenza A_Homo sapiens_hsa051640.11171914
120Primary immunodeficiency_Homo sapiens_hsa053400.11034494
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10993337
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10574013
123AMPK signaling pathway_Homo sapiens_hsa041520.10306110
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09873081
125Renin-angiotensin system_Homo sapiens_hsa046140.09504055
126Shigellosis_Homo sapiens_hsa051310.09444309
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.09419625
128Melanogenesis_Homo sapiens_hsa049160.09046638
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07971612
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05887506

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