MSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.08425941
2regulation of gamma-delta T cell differentiation (GO:0045586)4.71549936
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67537330
4negative regulation of cell killing (GO:0031342)4.67537330
5cytoplasmic mRNA processing body assembly (GO:0033962)4.61147594
6positive thymic T cell selection (GO:0045059)4.41876655
7regulation of gamma-delta T cell activation (GO:0046643)4.22629896
8positive regulation of histone deacetylation (GO:0031065)4.22106432
9negative T cell selection (GO:0043383)4.13097724
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08927875
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08927875
12negative thymic T cell selection (GO:0045060)3.99181438
13mitotic sister chromatid cohesion (GO:0007064)3.98123413
14positive T cell selection (GO:0043368)3.97786099
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94991692
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.94991692
17modulation by symbiont of host immune response (GO:0052553)3.94991692
18positive regulation by symbiont of host defense response (GO:0052509)3.94991692
19modulation by symbiont of host defense response (GO:0052031)3.94991692
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94991692
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.91189924
22antigen processing and presentation of endogenous antigen (GO:0019883)3.88902141
23thymic T cell selection (GO:0045061)3.83732721
24T cell selection (GO:0045058)3.70027816
25cellular response to interleukin-15 (GO:0071350)3.48689475
26negative regulation of histone methylation (GO:0031061)3.46445377
27negative regulation of T cell mediated immunity (GO:0002710)3.34723557
28macrophage activation involved in immune response (GO:0002281)3.33347071
29histone H3-K4 trimethylation (GO:0080182)3.28594711
30neutrophil activation involved in immune response (GO:0002283)3.28420700
31pre-miRNA processing (GO:0031054)3.25396037
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24281574
33phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.22657405
34protein localization to endosome (GO:0036010)3.20377228
35interferon-gamma production (GO:0032609)3.19487922
36tolerance induction (GO:0002507)3.19312304
37regulation of B cell receptor signaling pathway (GO:0050855)3.18680007
38mRNA stabilization (GO:0048255)3.18674548
39RNA stabilization (GO:0043489)3.18674548
40detection of other organism (GO:0098543)3.17964425
41histone H3-K36 demethylation (GO:0070544)3.17213708
42hepatocyte apoptotic process (GO:0097284)3.16576409
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.15141636
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15060480
45regulation of RNA export from nucleus (GO:0046831)3.11911304
46nuclear pore complex assembly (GO:0051292)3.11837586
47regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.04911109
48JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02657512
49positive regulation of protein deacetylation (GO:0090312)3.01878865
50response to interleukin-15 (GO:0070672)3.01447420
51NLS-bearing protein import into nucleus (GO:0006607)3.01394248
52response to muramyl dipeptide (GO:0032495)3.00850479
53regulation of interferon-beta biosynthetic process (GO:0045357)2.98859966
54response to peptidoglycan (GO:0032494)2.98232461
55positive regulation of B cell differentiation (GO:0045579)2.97453921
56B cell receptor signaling pathway (GO:0050853)2.96529437
57definitive hemopoiesis (GO:0060216)2.96208416
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96076797
59detection of bacterium (GO:0016045)2.95537427
60regulation of alpha-beta T cell proliferation (GO:0046640)2.94303139
61nuclear pore organization (GO:0006999)2.91007596
62peptidyl-lysine dimethylation (GO:0018027)2.89388861
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88871699
64response to host immune response (GO:0052572)2.88871699
65leukocyte aggregation (GO:0070486)2.88277186
66negative regulation of T-helper cell differentiation (GO:0045623)2.85820156
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85820156
68glucocorticoid receptor signaling pathway (GO:0042921)2.84465370
69positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.83571132
70peptidyl-lysine trimethylation (GO:0018023)2.82240321
71natural killer cell differentiation (GO:0001779)2.81815056
72T cell costimulation (GO:0031295)2.81496831
73histone H3-K9 demethylation (GO:0033169)2.78582487
74corticosteroid receptor signaling pathway (GO:0031958)2.78482115
75regulation of granulocyte differentiation (GO:0030852)2.78079924
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78045825
77microglial cell activation (GO:0001774)2.75078523
78growth hormone receptor signaling pathway (GO:0060396)2.74885056
79lymphocyte costimulation (GO:0031294)2.74282257
80negative regulation of leukocyte mediated immunity (GO:0002704)2.73018938
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72719491
82regulation of T cell tolerance induction (GO:0002664)2.72365427
83regulation of nucleobase-containing compound transport (GO:0032239)2.71702957
84negative regulation of interleukin-12 production (GO:0032695)2.70575685
85immunoglobulin mediated immune response (GO:0016064)2.69327638
86positive regulation of humoral immune response (GO:0002922)2.68979843
87positive regulation of mRNA catabolic process (GO:0061014)2.68917787
88myeloid cell activation involved in immune response (GO:0002275)2.68914303
89neutrophil activation (GO:0042119)2.68887680
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68719259
91response to host (GO:0075136)2.68719259
92response to host defenses (GO:0052200)2.68719259
933-UTR-mediated mRNA stabilization (GO:0070935)2.68691954
94regulation of DNA methylation (GO:0044030)2.68499434
95detection of molecule of bacterial origin (GO:0032490)2.67703164
96detection of external biotic stimulus (GO:0098581)2.66774198
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66545114
98germinal center formation (GO:0002467)2.66073438
99regulation of B cell differentiation (GO:0045577)2.64987828
100Peyers patch development (GO:0048541)2.64032318
101mucosal-associated lymphoid tissue development (GO:0048537)2.64032318
102regulation of mRNA stability (GO:0043488)2.63765574
103T cell receptor signaling pathway (GO:0050852)2.63223207
104regulation of histone deacetylation (GO:0031063)2.62302904
105positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.60974204
106regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.60974204
107regulation of histone H3-K9 methylation (GO:0051570)2.60673525
108antigen receptor-mediated signaling pathway (GO:0050851)2.58510150
109N-terminal protein amino acid acetylation (GO:0006474)2.57599722
110T cell homeostasis (GO:0043029)2.56569031
111regulation of mRNA catabolic process (GO:0061013)2.55469213
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55228046
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54915122
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54915122
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.54915122
116positive regulation of Rap GTPase activity (GO:0032854)2.53519475
117defense response to protozoan (GO:0042832)2.53039968
118negative regulation of erythrocyte differentiation (GO:0045647)2.50273023
119histone lysine demethylation (GO:0070076)2.50021709
120regulation of RNA stability (GO:0043487)2.49971571
121regulation of protein deacetylation (GO:0090311)2.47993172
122negative regulation of phagocytosis (GO:0050765)2.47709188
123regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.46621134
124T cell migration (GO:0072678)2.46260798
125positive regulation of interleukin-2 production (GO:0032743)2.43335084
126cellular extravasation (GO:0045123)2.43174179
127activated T cell proliferation (GO:0050798)2.42859835
128lymphocyte homeostasis (GO:0002260)2.41559790
129negative regulation of B cell proliferation (GO:0030889)2.37369611
130positive regulation of gene expression, epigenetic (GO:0045815)2.36644245
131alternative mRNA splicing, via spliceosome (GO:0000380)2.36217125
132histone H2A monoubiquitination (GO:0035518)2.34197767
133negative regulation of granulocyte differentiation (GO:0030853)2.33263781
134germ cell migration (GO:0008354)2.31745061
135B cell homeostasis (GO:0001782)2.29980742
136monoubiquitinated protein deubiquitination (GO:0035520)2.29968842
137histone H3-K4 methylation (GO:0051568)2.29405024
138positive regulation of granulocyte differentiation (GO:0030854)2.28955947
139embryonic process involved in female pregnancy (GO:0060136)2.28796970
140cellular response to growth hormone stimulus (GO:0071378)2.28170140
141histone demethylation (GO:0016577)2.27761800
142positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.27323766
143regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.27323766
144response to laminar fluid shear stress (GO:0034616)2.25345578
145cortical actin cytoskeleton organization (GO:0030866)2.24822409
146histone mRNA catabolic process (GO:0071044)2.24262546
147megakaryocyte development (GO:0035855)2.23087454
148mitotic chromosome condensation (GO:0007076)2.22670586
149negative regulation of histone modification (GO:0031057)2.22537627
150V(D)J recombination (GO:0033151)2.21099915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.07196234
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.91090437
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51337675
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47531278
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.42773454
6MYC_22102868_ChIP-Seq_BL_Human4.10447643
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.61878819
8TCF7_22412390_ChIP-Seq_EML_Mouse2.82960044
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.82689092
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75591594
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.69249013
12* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.56273377
13RUNX_20019798_ChIP-Seq_JUKART_Human2.56003467
14* VDR_21846776_ChIP-Seq_THP-1_Human2.55716221
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46095198
16* MAF_26560356_Chip-Seq_TH1_Human2.39153708
17MYB_26560356_Chip-Seq_TH2_Human2.37109326
18* KDM2B_26808549_Chip-Seq_DND41_Human2.35580193
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34727012
20* MYB_26560356_Chip-Seq_TH1_Human2.25133084
21* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23382250
22* UTX_26944678_Chip-Seq_JUKART_Human2.22758581
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22486055
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10104499
25SCL_19346495_ChIP-Seq_HPC-7_Human2.08728204
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08520302
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04569753
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90495885
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.88484894
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88155683
31VDR_24763502_ChIP-Seq_THP-1_Human1.80353956
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77810686
33* KDM2B_26808549_Chip-Seq_JURKAT_Human1.74201341
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68561874
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.67971068
36* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64073126
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62349357
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57066625
39SPI1_23127762_ChIP-Seq_K562_Human1.55629021
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.55156841
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49623878
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48475772
43GATA3_27048872_Chip-Seq_THYMUS_Human1.48120728
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45764504
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.44286320
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.43746601
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41280150
48GATA3_26560356_Chip-Seq_TH2_Human1.38106310
49GATA1_22025678_ChIP-Seq_K562_Human1.36607510
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34458155
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33816800
52* MAF_26560356_Chip-Seq_TH2_Human1.33804090
53NCOR1_26117541_ChIP-Seq_K562_Human1.33178869
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32989073
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31201040
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27909944
57PU_27001747_Chip-Seq_BMDM_Mouse1.27755348
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.27635107
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.26543797
60* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24060669
61* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23226353
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.20499714
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19571824
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19119121
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19093974
66* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16809398
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16002947
68FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15931824
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15714809
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.14511903
71* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14424551
72* SPI1_23547873_ChIP-Seq_NB4_Human1.10447698
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10031965
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.09085931
75GATA1_19941826_ChIP-Seq_K562_Human1.08292016
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08280944
77CLOCK_20551151_ChIP-Seq_293T_Human1.06357861
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06197871
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05740807
80KDM2B_26808549_Chip-Seq_K562_Human1.04510093
81CIITA_25753668_ChIP-Seq_RAJI_Human1.04370294
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03648288
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02681857
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01630060
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01529838
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.98651223
87SMRT_27268052_Chip-Seq_Bcells_Human0.98636633
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97466885
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97396358
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97153966
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96196747
92* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95477416
93TFEB_21752829_ChIP-Seq_HELA_Human0.93954218
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93674165
95GATA2_19941826_ChIP-Seq_K562_Human0.93506144
96* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93500468
97GATA6_25053715_ChIP-Seq_YYC3_Human0.93482938
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91323012
99CHD1_26751641_Chip-Seq_LNCaP_Human0.91152684
100GATA3_26560356_Chip-Seq_TH1_Human0.90812225
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90097415
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90097415
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90097415
104* VDR_24787735_ChIP-Seq_THP-1_Human0.88708219
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87108910
106GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86613909
107HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86248286
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86246627
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84659674
110* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83701042
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83552833
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83139200
113* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.79898690
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77871161
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.77319075
116* UBF1/2_26484160_Chip-Seq_HMECs_Human0.77226042
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76873136
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76358090
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.76180419
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75051249
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.73635280
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71349341
123* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.69890597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.90732016
2MP0003303_peritoneal_inflammation3.70955538
3MP0005076_abnormal_cell_differentiation2.95466536
4MP0003763_abnormal_thymus_physiology2.91187116
5MP0002166_altered_tumor_susceptibility2.66957517
6MP0001800_abnormal_humoral_immune2.63627660
7MP0010352_gastrointestinal_tract_polyps2.56514434
8MP0000685_abnormal_immune_system2.40747931
9MP0002396_abnormal_hematopoietic_system2.39733851
10MP0004808_abnormal_hematopoietic_stem2.38295639
11MP0005387_immune_system_phenotype2.35081475
12MP0001790_abnormal_immune_system2.35081475
13MP0010234_abnormal_vibrissa_follicle2.27658248
14MP0009278_abnormal_bone_marrow2.24908067
15MP0002398_abnormal_bone_marrow2.21010359
16MP0005671_abnormal_response_to2.17444725
17MP0002006_tumorigenesis2.08796413
18MP0001835_abnormal_antigen_presentation2.08383097
19MP0000703_abnormal_thymus_morphology2.07806078
20MP0002452_abnormal_antigen_presenting2.01805627
21MP0008877_abnormal_DNA_methylation1.98170561
22MP0002723_abnormal_immune_serum1.91349971
23MP0002420_abnormal_adaptive_immunity1.91297721
24MP0010307_abnormal_tumor_latency1.90299408
25MP0005000_abnormal_immune_tolerance1.89757540
26MP0001819_abnormal_immune_cell1.87853807
27MP0004381_abnormal_hair_follicle1.87585415
28MP0004510_myositis1.86917765
29MP0003705_abnormal_hypodermis_morpholog1.85245156
30MP0008961_abnormal_basal_metabolism1.82312964
31MP0003436_decreased_susceptibility_to1.82047927
32MP0000569_abnormal_digit_pigmentation1.82000691
33MP0000716_abnormal_immune_system1.80865254
34MP0002722_abnormal_immune_system1.76239433
35MP0002405_respiratory_system_inflammati1.75883283
36MP0000689_abnormal_spleen_morphology1.75709122
37MP0004947_skin_inflammation1.72004363
38MP0010155_abnormal_intestine_physiology1.71324238
39MP0004185_abnormal_adipocyte_glucose1.66148386
40MP0003656_abnormal_erythrocyte_physiolo1.64330956
41MP0001873_stomach_inflammation1.63863903
42MP0001545_abnormal_hematopoietic_system1.63454484
43MP0005397_hematopoietic_system_phenotyp1.63454484
44MP0002429_abnormal_blood_cell1.50114113
45MP0005025_abnormal_response_to1.39824397
46MP0003866_abnormal_defecation1.39530717
47MP0005075_abnormal_melanosome_morpholog1.37051631
48MP0005464_abnormal_platelet_physiology1.36584277
49MP0003091_abnormal_cell_migration1.36184472
50MP0009333_abnormal_splenocyte_physiolog1.33629923
51MP0002148_abnormal_hypersensitivity_rea1.32029156
52MP0002009_preneoplasia1.31916006
53MP0000465_gastrointestinal_hemorrhage1.30605570
54MP0003221_abnormal_cardiomyocyte_apopto1.29630955
55MP0002419_abnormal_innate_immunity1.29377757
56MP0000490_abnormal_crypts_of1.26198245
57MP0001853_heart_inflammation1.26160299
58MP0001845_abnormal_inflammatory_respons1.25638599
59MP0005310_abnormal_salivary_gland1.23868233
60MP0002138_abnormal_hepatobiliary_system1.22366622
61MP0003566_abnormal_cell_adhesion1.20604342
62MP0008057_abnormal_DNA_replication1.16359622
63MP0005451_abnormal_body_composition1.14409028
64MP0001849_ear_inflammation1.13493645
65MP0003172_abnormal_lysosome_physiology1.12523045
66MP0002877_abnormal_melanocyte_morpholog1.09871103
67MP0008260_abnormal_autophagy1.09482457
68MP0000733_abnormal_muscle_development1.08822727
69MP0002086_abnormal_extraembryonic_tissu1.08725292
70MP0002277_abnormal_respiratory_mucosa1.08475264
71MP0000015_abnormal_ear_pigmentation1.07779261
72MP0003045_fibrosis1.07468362
73MP0003448_altered_tumor_morphology1.05242836
74MP0000350_abnormal_cell_proliferation1.03380199
75MP0006082_CNS_inflammation1.02561453
76MP0003077_abnormal_cell_cycle1.01934436
77MP0010094_abnormal_chromosome_stability1.01907873
78MP0001851_eye_inflammation1.00229683
79MP0008058_abnormal_DNA_repair0.99768455
80MP0009785_altered_susceptibility_to0.98287312
81MP0002019_abnormal_tumor_incidence0.97672270
82MP0003183_abnormal_peptide_metabolism0.95356925
83MP0002132_abnormal_respiratory_system0.93830000
84MP0002928_abnormal_bile_duct0.93756927
85MP0001915_intracranial_hemorrhage0.93018682
86MP0003828_pulmonary_edema0.89655480
87MP0003453_abnormal_keratinocyte_physiol0.88568780
88MP0003252_abnormal_bile_duct0.88343003
89MP0004264_abnormal_extraembryonic_tissu0.87312791
90MP0002088_abnormal_embryonic_growth/wei0.86379231
91MP0003984_embryonic_growth_retardation0.85969642
92MP0002925_abnormal_cardiovascular_devel0.85706130
93MP0003890_abnormal_embryonic-extraembry0.84945692
94MP0005666_abnormal_adipose_tissue0.84138487
95MP0003787_abnormal_imprinting0.83800525
96MP0003943_abnormal_hepatobiliary_system0.82278841
97MP0010678_abnormal_skin_adnexa0.80800143
98MP0001533_abnormal_skeleton_physiology0.80295750
99MP0009115_abnormal_fat_cell0.80061952
100MP0001730_embryonic_growth_arrest0.79313207
101MP0001672_abnormal_embryogenesis/_devel0.79281083
102MP0005380_embryogenesis_phenotype0.79281083
103MP0003724_increased_susceptibility_to0.79179225
104MP0005174_abnormal_tail_pigmentation0.79109377
105MP0000609_abnormal_liver_physiology0.79089949
106MP0004197_abnormal_fetal_growth/weight/0.78367336
107MP0008469_abnormal_protein_level0.76614417
108MP0005621_abnormal_cell_physiology0.75412287
109MP0000858_altered_metastatic_potential0.74484114
110MP0005023_abnormal_wound_healing0.74363307
111MP0009703_decreased_birth_body0.73868931
112MP0000313_abnormal_cell_death0.73680242
113MP0002998_abnormal_bone_remodeling0.73677515
114MP0002933_joint_inflammation0.71908673
115MP0002971_abnormal_brown_adipose0.71316224
116MP0003111_abnormal_nucleus_morphology0.71284124
117MP0004883_abnormal_blood_vessel0.70957135
118MP0009672_abnormal_birth_weight0.70869095
119MP0003191_abnormal_cellular_cholesterol0.70822920
120MP0006054_spinal_hemorrhage0.70134731
121MP0005375_adipose_tissue_phenotype0.68598252
122MP0003693_abnormal_embryo_hatching0.61042890
123MP0003699_abnormal_female_reproductive0.58396671

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.57312660
2T lymphocytopenia (HP:0005403)3.88791027
3Abnormality of T cell number (HP:0011839)3.68709531
4Recurrent viral infections (HP:0004429)3.59071698
5Hematochezia (HP:0002573)3.37269105
6Recurrent fungal infections (HP:0002841)3.02883127
7Abnormal delayed hypersensitivity skin test (HP:0002963)2.99412016
8Recurrent skin infections (HP:0001581)2.96656348
9Spontaneous hematomas (HP:0007420)2.95661483
10Volvulus (HP:0002580)2.95478865
11Optic neuritis (HP:0100653)2.94213062
12Retrobulbar optic neuritis (HP:0100654)2.94213062
13Abnormality of B cell number (HP:0010975)2.93796926
14B lymphocytopenia (HP:0010976)2.93796926
15Encephalitis (HP:0002383)2.90710699
16Panhypogammaglobulinemia (HP:0003139)2.87013226
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85768153
18Gastrointestinal infarctions (HP:0005244)2.82740832
19Recurrent gram-negative bacterial infections (HP:0005420)2.80392026
20Abnormality of macrophages (HP:0004311)2.76289247
21Orchitis (HP:0100796)2.75288501
22Acute lymphatic leukemia (HP:0006721)2.70401082
23Thyroiditis (HP:0100646)2.69291935
24Macroorchidism (HP:0000053)2.68064742
25Osteomyelitis (HP:0002754)2.67892060
26Autoimmune thrombocytopenia (HP:0001973)2.66119449
27Inflammation of the large intestine (HP:0002037)2.65498601
28Colitis (HP:0002583)2.65455499
29Verrucae (HP:0200043)2.64209581
30Papilloma (HP:0012740)2.64209581
31Papillary thyroid carcinoma (HP:0002895)2.63049624
32Abnormality of T cells (HP:0002843)2.60868629
33Gastrointestinal inflammation (HP:0004386)2.55713714
34Chronic otitis media (HP:0000389)2.55564162
35Cellulitis (HP:0100658)2.53222165
36Hypochromic microcytic anemia (HP:0004840)2.50752665
37Gingivitis (HP:0000230)2.46135062
38Eczematoid dermatitis (HP:0000976)2.44115997
39Recurrent bronchitis (HP:0002837)2.43401947
40Long eyelashes (HP:0000527)2.43302373
41IgM deficiency (HP:0002850)2.42219025
42Keratoconjunctivitis sicca (HP:0001097)2.41573802
43Cerebral aneurysm (HP:0004944)2.37817118
44Increased density of long bones (HP:0006392)2.37496808
45Elevated erythrocyte sedimentation rate (HP:0003565)2.34329521
46Nasal polyposis (HP:0100582)2.33357434
47Agammaglobulinemia (HP:0004432)2.28488549
48Amaurosis fugax (HP:0100576)2.25222484
49Lymphoma (HP:0002665)2.21428111
50Keratoconjunctivitis (HP:0001096)2.20922702
51Eosinophilia (HP:0001880)2.19368886
52Increased IgE level (HP:0003212)2.19070367
53Abnormal hair whorl (HP:0010721)2.18872812
54Meningitis (HP:0001287)2.18102470
55Aortic aneurysm (HP:0004942)2.16439257
56Urethral obstruction (HP:0000796)2.15418641
57Chronic obstructive pulmonary disease (HP:0006510)2.14889939
58Obstructive lung disease (HP:0006536)2.14889939
59Recurrent cutaneous fungal infections (HP:0011370)2.14382470
60Chronic mucocutaneous candidiasis (HP:0002728)2.14382470
61Hyperacusis (HP:0010780)2.13600425
62Combined immunodeficiency (HP:0005387)2.12886908
63Abnormality of the nasal mucosa (HP:0000433)2.12744277
64Severe combined immunodeficiency (HP:0004430)2.11579648
65Short 4th metacarpal (HP:0010044)2.10883460
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10883460
67Hypochromic anemia (HP:0001931)2.08555308
68Narrow palate (HP:0000189)2.08144320
69Rectal prolapse (HP:0002035)2.08080752
70Mitral valve prolapse (HP:0001634)2.07571326
71Subacute progressive viral hepatitis (HP:0006572)2.07471293
72Arterial thrombosis (HP:0004420)2.07344383
73Urticaria (HP:0001025)2.05353889
74Sandal gap (HP:0001852)2.04707899
75Heterotopia (HP:0002282)2.04543760
76Slow saccadic eye movements (HP:0000514)2.04326204
77Persistence of primary teeth (HP:0006335)2.03099232
78Myositis (HP:0100614)1.99757957
79Cutis marmorata (HP:0000965)1.99398041
80Dysmetric saccades (HP:0000641)1.99212181
81Truncal obesity (HP:0001956)1.98982664
82Hemoptysis (HP:0002105)1.97574705
83Basal cell carcinoma (HP:0002671)1.95909933
84Acute myeloid leukemia (HP:0004808)1.94719926
85Pulmonary infiltrates (HP:0002113)1.92541171
86Myocardial infarction (HP:0001658)1.92343168
87Abnormal platelet volume (HP:0011876)1.92314724
88Abnormality of chromosome segregation (HP:0002916)1.91581964
89Lymphopenia (HP:0001888)1.91237967
90Chest pain (HP:0100749)1.90673112
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.89277686
92Papilledema (HP:0001085)1.88376536
93Transitional cell carcinoma of the bladder (HP:0006740)1.87994171
94Absent frontal sinuses (HP:0002688)1.87795109
95Prolonged bleeding time (HP:0003010)1.87666318
96Pseudobulbar signs (HP:0002200)1.87495478
97Abnormality of cells of the lymphoid lineage (HP:0012140)1.87477211
98Neoplasm of the tracheobronchial system (HP:0100552)1.87084936
99Malignant gastrointestinal tract tumors (HP:0006749)1.86353867
100Gastrointestinal carcinoma (HP:0002672)1.86353867
101Abnormality of eosinophils (HP:0001879)1.85923142
102Sepsis (HP:0100806)1.85773943
103Fair hair (HP:0002286)1.85417933
104Stomatitis (HP:0010280)1.85415514
105Periodontitis (HP:0000704)1.83516496
106Recurrent bacterial skin infections (HP:0005406)1.82456736
107Viral hepatitis (HP:0006562)1.82280083
108Prominent nose (HP:0000448)1.82199276
109Vertebral arch anomaly (HP:0008438)1.81821955
110Vasculitis (HP:0002633)1.81274061
111Epistaxis (HP:0000421)1.80635006
112Microcytic anemia (HP:0001935)1.80288391
113Fatigue (HP:0012378)1.78853761
114Disproportionate tall stature (HP:0001519)1.78520731
115High pitched voice (HP:0001620)1.77684525
116Abnormality of T cell physiology (HP:0011840)1.77619622
117Autoimmune hemolytic anemia (HP:0001890)1.76542553
118Recurrent abscess formation (HP:0002722)1.75835219
119Leukocytosis (HP:0001974)1.75652748
120Increased nuchal translucency (HP:0010880)1.75369650
121Bladder carcinoma (HP:0002862)1.75062152
122Bladder neoplasm (HP:0009725)1.75062152
123Pustule (HP:0200039)1.74769599
124Disinhibition (HP:0000734)1.74357859
125Hypoplasia of the thymus (HP:0000778)1.72029555
126Low anterior hairline (HP:0000294)1.71235756
127Granulocytopenia (HP:0001913)1.70347956
128Spinal cord lesions (HP:0100561)1.69421794
129Syringomyelia (HP:0003396)1.69421794
130Mediastinal lymphadenopathy (HP:0100721)1.68701159
131Gingival bleeding (HP:0000225)1.67919610
132IgA deficiency (HP:0002720)1.66090972
133Abnormality of oral frenula (HP:0000190)1.64804373
134Thrombocytosis (HP:0001894)1.64757095
135Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63751686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.59988957
2CDK123.47147348
3RIPK43.36136441
4MAP3K103.07566958
5EEF2K3.03192498
6PRPF4B2.88130660
7TRIB32.42222800
8STK102.40204878
9PKN22.30501753
10GRK62.08023019
11IRAK41.94124039
12FGFR31.90902837
13TYK21.90055927
14YES11.89916531
15TXK1.83179202
16PTK61.76590611
17JAK31.76482622
18JAK11.65123537
19SIK21.61124765
20CAMK1D1.60955223
21ITK1.60571833
22CAMK1G1.57802304
23CDK61.54559518
24TAOK31.52858389
25TNK21.51904932
26LATS11.51590040
27FGFR41.51000240
28IRAK21.48119486
29TGFBR21.46121027
30MELK1.38335290
31IRAK11.35860550
32SIK31.34518561
33ALK1.34058171
34ZAP701.32919148
35LRRK21.30426543
36HIPK21.27608821
37MAP3K11.26127573
38PIM11.22649333
39DMPK1.22459462
40EPHB11.20878657
41RPS6KA41.20487602
42CDK91.18520910
43CSK1.17876599
44CDK41.16538904
45HCK1.16522890
46JAK21.16236517
47BTK1.15412272
48STK31.15241002
49NEK21.13307116
50BRD41.12121575
51IKBKE1.10212970
52BLK1.08539717
53TAOK11.07904320
54MARK31.04585119
55NLK1.03468244
56RAF11.03030085
57RIPK11.01861566
58PASK1.01080184
59FGFR20.97874031
60CDC70.96505128
61LYN0.96461001
62SGK30.96410720
63MAP3K140.94947075
64SIK10.94934349
65WNK10.93963688
66SMG10.93810007
67NEK60.93423075
68PRKCH0.93385067
69PDGFRB0.91381415
70LCK0.91371069
71FES0.91254058
72CSF1R0.87807225
73BMPR20.87592691
74CHUK0.86991113
75SYK0.86474687
76MAP3K70.86245455
77FRK0.85757076
78ERN10.85611761
79KSR10.85569922
80STK40.84412324
81MAP3K130.83262552
82MTOR0.80466294
83RET0.80100036
84PRKD20.79072795
85MAP2K30.78695590
86TEC0.78667636
87TTN0.77928933
88AKT30.75085019
89MAPK70.72072731
90PDK10.71026390
91FGR0.70980847
92CAMKK20.70964457
93STK110.68823859
94PDGFRA0.68774865
95MAP3K80.68636707
96TYRO30.68506775
97STK240.66997760
98TBK10.66970594
99SCYL20.66125245
100MAPK120.60556086
101MAP3K30.59369621
102MKNK20.59151011
103BRSK20.58389030
104CLK10.57113744
105BMX0.56205216
106KIT0.55825044
107IKBKB0.55506448
108MARK20.54677369
109CDK30.54320325
110SGK20.52398583
111CAMKK10.50501730
112EPHA30.47558566
113RPS6KB20.47018044
114MAP3K20.46427048
115PIK3CG0.45898102
116NEK90.44712634
117ATM0.44622625
118CAMK40.44465514
119PRKCQ0.44447246
120TAF10.44287537
121EGFR0.43138493
122KSR20.43084689
123ATR0.42023897
124SGK2230.41852353
125SGK4940.41852353
126STK380.41140442
127ACVR1B0.40356140
128CSNK1D0.39592600
129CHEK10.37961290
130ABL10.36651618
131MAP3K60.36576185
132NUAK10.35320890
133FGFR10.35307056

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.47435784
2B cell receptor signaling pathway_Homo sapiens_hsa046622.35258820
3T cell receptor signaling pathway_Homo sapiens_hsa046602.02082318
4Osteoclast differentiation_Homo sapiens_hsa043801.94652533
5Chronic myeloid leukemia_Homo sapiens_hsa052201.91672314
6Nitrogen metabolism_Homo sapiens_hsa009101.88197433
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69022993
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.62140200
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61093629
10Leishmaniasis_Homo sapiens_hsa051401.58227309
11Graft-versus-host disease_Homo sapiens_hsa053321.58051982
12Allograft rejection_Homo sapiens_hsa053301.56776957
13Measles_Homo sapiens_hsa051621.53385180
14Pancreatic cancer_Homo sapiens_hsa052121.52197724
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50156530
16Acute myeloid leukemia_Homo sapiens_hsa052211.48829382
17Autoimmune thyroid disease_Homo sapiens_hsa053201.45756313
18Lysine degradation_Homo sapiens_hsa003101.44829818
19Non-small cell lung cancer_Homo sapiens_hsa052231.44822092
20Antigen processing and presentation_Homo sapiens_hsa046121.43375318
21mTOR signaling pathway_Homo sapiens_hsa041501.41707653
22Toxoplasmosis_Homo sapiens_hsa051451.38740649
23Hepatitis B_Homo sapiens_hsa051611.36425046
24Dorso-ventral axis formation_Homo sapiens_hsa043201.32070016
25Type I diabetes mellitus_Homo sapiens_hsa049401.31747056
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.27730245
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.27594340
28Chemokine signaling pathway_Homo sapiens_hsa040621.26105102
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.24871300
30Colorectal cancer_Homo sapiens_hsa052101.23488651
31Small cell lung cancer_Homo sapiens_hsa052221.23340069
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22503388
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21192716
34Prolactin signaling pathway_Homo sapiens_hsa049171.20697177
35Insulin resistance_Homo sapiens_hsa049311.19830647
36MicroRNAs in cancer_Homo sapiens_hsa052061.19360396
37Platelet activation_Homo sapiens_hsa046111.17774523
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.17494750
39Endometrial cancer_Homo sapiens_hsa052131.15822961
40VEGF signaling pathway_Homo sapiens_hsa043701.15066114
41Herpes simplex infection_Homo sapiens_hsa051681.14947725
42Hematopoietic cell lineage_Homo sapiens_hsa046401.14130844
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13196287
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12171941
45Prostate cancer_Homo sapiens_hsa052151.10111525
46TNF signaling pathway_Homo sapiens_hsa046681.10044256
47Renal cell carcinoma_Homo sapiens_hsa052111.09688924
48Viral myocarditis_Homo sapiens_hsa054161.07794860
49FoxO signaling pathway_Homo sapiens_hsa040681.06531129
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05200968
51Adherens junction_Homo sapiens_hsa045201.04573393
52Influenza A_Homo sapiens_hsa051641.04404893
53Staphylococcus aureus infection_Homo sapiens_hsa051501.03785777
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03038203
55Type II diabetes mellitus_Homo sapiens_hsa049301.02439492
56HTLV-I infection_Homo sapiens_hsa051661.01047002
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00010920
58Glioma_Homo sapiens_hsa052140.99908311
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96562543
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96086267
61Viral carcinogenesis_Homo sapiens_hsa052030.94868097
62Notch signaling pathway_Homo sapiens_hsa043300.93193785
63Apoptosis_Homo sapiens_hsa042100.91225205
64Proteoglycans in cancer_Homo sapiens_hsa052050.88958220
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87931323
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86630960
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82843872
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81465457
69Estrogen signaling pathway_Homo sapiens_hsa049150.80701575
70Tuberculosis_Homo sapiens_hsa051520.80449181
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78962778
72Inositol phosphate metabolism_Homo sapiens_hsa005620.78695575
73Asthma_Homo sapiens_hsa053100.78242373
74Choline metabolism in cancer_Homo sapiens_hsa052310.75623817
75Malaria_Homo sapiens_hsa051440.75286494
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75083553
77Hepatitis C_Homo sapiens_hsa051600.74728849
78p53 signaling pathway_Homo sapiens_hsa041150.74276749
79MAPK signaling pathway_Homo sapiens_hsa040100.74045243
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.73757156
81Shigellosis_Homo sapiens_hsa051310.70765647
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69007764
83Focal adhesion_Homo sapiens_hsa045100.68953782
84Circadian rhythm_Homo sapiens_hsa047100.68622587
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64690287
86African trypanosomiasis_Homo sapiens_hsa051430.64637878
87GnRH signaling pathway_Homo sapiens_hsa049120.64284160
88mRNA surveillance pathway_Homo sapiens_hsa030150.62908308
89HIF-1 signaling pathway_Homo sapiens_hsa040660.62538078
90AMPK signaling pathway_Homo sapiens_hsa041520.61863722
91ErbB signaling pathway_Homo sapiens_hsa040120.61139211
92Thyroid cancer_Homo sapiens_hsa052160.60134907
93Rap1 signaling pathway_Homo sapiens_hsa040150.59369606
94Non-homologous end-joining_Homo sapiens_hsa034500.59126274
95Insulin signaling pathway_Homo sapiens_hsa049100.58253312
96Pathways in cancer_Homo sapiens_hsa052000.57956869
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.57938130
98Pertussis_Homo sapiens_hsa051330.55814725
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55512594
100RNA degradation_Homo sapiens_hsa030180.54106102
101Cell cycle_Homo sapiens_hsa041100.52556032
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.52303995
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51905036
104Long-term potentiation_Homo sapiens_hsa047200.51271792
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50798670
106Amoebiasis_Homo sapiens_hsa051460.49858009
107Endocytosis_Homo sapiens_hsa041440.48809352
108Epstein-Barr virus infection_Homo sapiens_hsa051690.47629126
109Glucagon signaling pathway_Homo sapiens_hsa049220.47424870
110Fanconi anemia pathway_Homo sapiens_hsa034600.47284697
111Legionellosis_Homo sapiens_hsa051340.47223916
112Regulation of autophagy_Homo sapiens_hsa041400.46643025
113TGF-beta signaling pathway_Homo sapiens_hsa043500.46584224
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45689219
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.45526919
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45248319
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44660226
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44307553
119Long-term depression_Homo sapiens_hsa047300.44014616

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