MSL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.47393728
2negative regulation of cell killing (GO:0031342)6.47393728
3regulation of B cell receptor signaling pathway (GO:0050855)5.59364293
4positive regulation by symbiont of host defense response (GO:0052509)4.98156524
5modulation by symbiont of host defense response (GO:0052031)4.98156524
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.98156524
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.98156524
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.98156524
9modulation by symbiont of host immune response (GO:0052553)4.98156524
10negative T cell selection (GO:0043383)4.86415235
11negative thymic T cell selection (GO:0045060)4.86041595
12regulation of gamma-delta T cell activation (GO:0046643)4.84309283
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.44135316
14detection of other organism (GO:0098543)4.43324541
15regulation of gamma-delta T cell differentiation (GO:0045586)4.42316927
16detection of bacterium (GO:0016045)4.38836955
17response to interleukin-15 (GO:0070672)4.36517637
18leukocyte aggregation (GO:0070486)4.28722333
19B cell receptor signaling pathway (GO:0050853)4.23186973
20negative regulation of T cell mediated immunity (GO:0002710)4.18513270
21cellular response to interleukin-15 (GO:0071350)4.13852918
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.13145027
23T cell migration (GO:0072678)4.12697550
24cellular response to type I interferon (GO:0071357)4.04929980
25type I interferon signaling pathway (GO:0060337)4.04929980
26response to type I interferon (GO:0034340)4.00510494
27macrophage activation involved in immune response (GO:0002281)3.98883531
28positive thymic T cell selection (GO:0045059)3.96299861
29tolerance induction (GO:0002507)3.95603655
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.93979419
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93979419
32T cell selection (GO:0045058)3.82875184
33positive T cell selection (GO:0043368)3.80992187
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80711108
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.79911623
36negative regulation of interleukin-12 production (GO:0032695)3.79742669
37cellular extravasation (GO:0045123)3.77878336
38regulation of T cell tolerance induction (GO:0002664)3.77564556
39regulation of alpha-beta T cell proliferation (GO:0046640)3.76744168
40response to peptidoglycan (GO:0032494)3.68988387
41thymic T cell selection (GO:0045061)3.68943396
42interferon-gamma-mediated signaling pathway (GO:0060333)3.65414948
43detection of external biotic stimulus (GO:0098581)3.59935092
44negative regulation of leukocyte mediated immunity (GO:0002704)3.57871981
45response to host immune response (GO:0052572)3.56916665
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56916665
47activated T cell proliferation (GO:0050798)3.54002666
48regulation of tolerance induction (GO:0002643)3.52565619
49ribosomal small subunit assembly (GO:0000028)3.50787945
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50550646
51response to muramyl dipeptide (GO:0032495)3.45296065
52antigen processing and presentation of endogenous antigen (GO:0019883)3.43452962
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.41582555
54defense response to protozoan (GO:0042832)3.37299249
55microglial cell activation (GO:0001774)3.32032696
56response to host (GO:0075136)3.30253754
57response to host defenses (GO:0052200)3.30253754
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30253754
59B cell mediated immunity (GO:0019724)3.30237819
60antigen receptor-mediated signaling pathway (GO:0050851)3.24443161
61myeloid cell activation involved in immune response (GO:0002275)3.23605685
62antigen processing and presentation via MHC class Ib (GO:0002475)3.23551065
63B cell homeostasis (GO:0001782)3.22498997
64regulation of natural killer cell mediated immunity (GO:0002715)3.21422784
65regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21422784
66regulation of interleukin-2 biosynthetic process (GO:0045076)3.19784526
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19214735
68mast cell activation (GO:0045576)3.18566219
69regulation of T cell mediated cytotoxicity (GO:0001914)3.18038457
70positive regulation of tolerance induction (GO:0002645)3.17796758
71detection of molecule of bacterial origin (GO:0032490)3.17491011
72detection of biotic stimulus (GO:0009595)3.16487298
73positive regulation of granulocyte differentiation (GO:0030854)3.16045140
74regulation of regulatory T cell differentiation (GO:0045589)3.15965794
75respiratory burst (GO:0045730)3.15511736
76telomere maintenance via semi-conservative replication (GO:0032201)3.14771736
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14501137
78positive regulation of humoral immune response (GO:0002922)3.13964907
79germinal center formation (GO:0002467)3.13420668
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.12839770
81DNA strand elongation involved in DNA replication (GO:0006271)3.10735055
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10501894
83neutrophil activation (GO:0042119)3.10428579
84interferon-gamma production (GO:0032609)3.08710416
85NIK/NF-kappaB signaling (GO:0038061)3.08527543
86positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06444670
87negative regulation of alpha-beta T cell activation (GO:0046636)3.03843557
88positive regulation of B cell differentiation (GO:0045579)3.03711405
89response to protozoan (GO:0001562)3.02307799
90myeloid dendritic cell activation (GO:0001773)3.02201955
91T cell receptor signaling pathway (GO:0050852)2.99717146
92telomere maintenance via recombination (GO:0000722)2.99555448
93T cell homeostasis (GO:0043029)2.96942133
94negative regulation of adaptive immune response (GO:0002820)2.96534931
95DNA strand elongation (GO:0022616)2.96148045
96lymphocyte homeostasis (GO:0002260)2.95409350
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94950872
98regulation of RIG-I signaling pathway (GO:0039535)2.88655971
99negative regulation of phagocytosis (GO:0050765)2.88174386
100DNA unwinding involved in DNA replication (GO:0006268)2.79631223
101necroptotic process (GO:0070266)2.77782049
102definitive hemopoiesis (GO:0060216)2.74524083
103mitotic recombination (GO:0006312)2.73406770
104lysine catabolic process (GO:0006554)2.73113028
105lysine metabolic process (GO:0006553)2.73113028
106Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69613906
107hepatocyte apoptotic process (GO:0097284)2.65107850
108pentose-phosphate shunt (GO:0006098)2.64218962
109regulation of necroptotic process (GO:0060544)2.60692278
110NADPH regeneration (GO:0006740)2.60496884
111positive regulation of gamma-delta T cell activation (GO:0046645)2.58763239
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57117440
113folic acid-containing compound biosynthetic process (GO:0009396)2.56583601
114DNA replication initiation (GO:0006270)2.54096636
115regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.45962800
116signal peptide processing (GO:0006465)2.42032750
117CENP-A containing nucleosome assembly (GO:0034080)2.39729521
118T cell apoptotic process (GO:0070231)2.39462191
119viral transcription (GO:0019083)2.39087288
120translational termination (GO:0006415)2.36877627
121chaperone mediated protein folding requiring cofactor (GO:0051085)2.35957679
122negative regulation of necroptotic process (GO:0060546)2.35869846
123neutrophil activation involved in immune response (GO:0002283)2.35683981
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34171607
125cellular response to zinc ion (GO:0071294)2.33358205
126valine metabolic process (GO:0006573)2.32457574
127positive regulation of interferon-alpha production (GO:0032727)2.32315445
128protein localization to kinetochore (GO:0034501)2.30555047
1292-oxoglutarate metabolic process (GO:0006103)2.26831096
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.25669934
131positive regulation of natural killer cell differentiation (GO:0032825)2.25348285
132purine-containing compound salvage (GO:0043101)2.25283310
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.24808485
134DNA replication checkpoint (GO:0000076)2.23685963
135folic acid metabolic process (GO:0046655)2.23396737
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.22136718
137tricarboxylic acid cycle (GO:0006099)2.20947691
138chromatin remodeling at centromere (GO:0031055)2.20757181
139histone-serine phosphorylation (GO:0035404)2.20564828
140translational elongation (GO:0006414)2.19691225
141regulation of B cell differentiation (GO:0045577)2.19335965
142glyoxylate metabolic process (GO:0046487)2.19176372
143cotranslational protein targeting to membrane (GO:0006613)2.16979517
144protein targeting to ER (GO:0045047)2.16713793
145mitotic chromosome condensation (GO:0007076)2.16208874
146aldehyde catabolic process (GO:0046185)2.16147165
147programmed necrotic cell death (GO:0097300)2.16112254
148regulation of necrotic cell death (GO:0010939)2.15836989
149regulation of interferon-alpha production (GO:0032647)2.14858515
150AMP metabolic process (GO:0046033)2.14460569
151negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.13476104
152telomere maintenance via telomere lengthening (GO:0010833)2.13126033
153mitochondrial calcium ion transport (GO:0006851)2.12510053
154IMP metabolic process (GO:0046040)2.11375924
155megakaryocyte development (GO:0035855)2.10293376
156protein localization to endoplasmic reticulum (GO:0070972)2.09095928
157fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.08333129
158regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.08084055
159pteridine-containing compound biosynthetic process (GO:0042559)2.08047966
160purine nucleobase metabolic process (GO:0006144)2.07696208
161heart process (GO:0003015)2.07405957
162heart contraction (GO:0060047)2.07405957
163nucleobase biosynthetic process (GO:0046112)2.07271060
164purine nucleobase biosynthetic process (GO:0009113)2.07094434
165establishment of protein localization to endoplasmic reticulum (GO:0072599)2.06228136
166killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.06116333
167disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.06116333
168positive regulation of protein import into nucleus, translocation (GO:0033160)2.05605065
169oxaloacetate metabolic process (GO:0006107)2.04880781
170attachment of spindle microtubules to kinetochore (GO:0008608)2.04374008
171cellular glucuronidation (GO:0052695)2.04152400
172regulation of interferon-beta biosynthetic process (GO:0045357)2.03394309
173serine family amino acid biosynthetic process (GO:0009070)2.02263032
174response to interferon-beta (GO:0035456)2.02192593
175uronic acid metabolic process (GO:0006063)2.02139837
176glucuronate metabolic process (GO:0019585)2.02139837
177glucose catabolic process (GO:0006007)2.00571011
178regulation of response to interferon-gamma (GO:0060330)2.00559401
179tricarboxylic acid metabolic process (GO:0072350)2.00544026
180positive regulation of mitochondrial calcium ion concentration (GO:0051561)1.99529537
181actin nucleation (GO:0045010)1.99522068
182mitotic nuclear envelope disassembly (GO:0007077)1.99167665
183protein localization to chromosome, centromeric region (GO:0071459)1.99036957
184mitotic metaphase plate congression (GO:0007080)1.98633630
185lymphocyte apoptotic process (GO:0070227)1.97668779
186telomere maintenance (GO:0000723)1.96844218
187immunoglobulin mediated immune response (GO:0016064)1.96707560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.81621291
2RUNX_20019798_ChIP-Seq_JUKART_Human3.44922770
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.15061568
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86050776
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84482373
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.53393920
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47284733
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.41373382
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.31606960
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30749046
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27441244
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25391211
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.24892737
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22723460
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18421266
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17833225
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15499388
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13369898
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.10658037
20AR_21909140_ChIP-Seq_LNCAP_Human2.10102369
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.05543248
22GATA3_27048872_Chip-Seq_THYMUS_Human2.03569312
23SPI1_23127762_ChIP-Seq_K562_Human2.02057388
24MAF_26560356_Chip-Seq_TH2_Human2.00265341
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97856342
26GATA1_22025678_ChIP-Seq_K562_Human1.97583003
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.95530064
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94609494
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93102112
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92739525
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88453081
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88092716
33GATA3_26560356_Chip-Seq_TH2_Human1.84019391
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.82663698
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82149189
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.79625645
37SCL_19346495_ChIP-Seq_HPC-7_Human1.78179905
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75690850
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74140337
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71995446
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71878756
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70026448
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69650704
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69072592
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69017604
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.68895824
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67667259
48* SPI1_23547873_ChIP-Seq_NB4_Human1.63453663
49VDR_23849224_ChIP-Seq_CD4+_Human1.61876174
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61263912
51* VDR_24787735_ChIP-Seq_THP-1_Human1.58555466
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56598522
53TCF7_22412390_ChIP-Seq_EML_Mouse1.54395748
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54130877
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53959208
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53497890
57MYB_26560356_Chip-Seq_TH2_Human1.52892464
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50910897
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49884647
60FOXP3_21729870_ChIP-Seq_TREG_Human1.48533778
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48490364
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48487868
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48424305
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47960292
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47070593
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46477455
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45829333
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.44385819
69MYC_22102868_ChIP-Seq_BL_Human1.43754609
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43692830
71ELK1_19687146_ChIP-ChIP_HELA_Human1.43340009
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42877449
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.41738189
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.39434337
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38423510
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33979798
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33568613
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31845773
79MYB_26560356_Chip-Seq_TH1_Human1.31384956
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30719266
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30680084
82PU_27001747_Chip-Seq_BMDM_Mouse1.30404289
83DCP1A_22483619_ChIP-Seq_HELA_Human1.28940015
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28391977
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28135657
86VDR_21846776_ChIP-Seq_THP-1_Human1.27746946
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27683517
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27494453
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27458204
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25642840
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24887619
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23073024
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.22924352
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22883449
95MAF_26560356_Chip-Seq_TH1_Human1.22232214
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21551785
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19809603
98KDM2B_26808549_Chip-Seq_DND41_Human1.19660402
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18625025
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18089507
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.17720055
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17159649
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16914768
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16277876
105CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15916622
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14608840
107CLOCK_20551151_ChIP-Seq_293T_Human1.13574374
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12880246
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12726497
110GABP_19822575_ChIP-Seq_HepG2_Human1.12129888
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12061059
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12020676
113XRN2_22483619_ChIP-Seq_HELA_Human1.11426197
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10289992
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10041762
116UTX_26944678_Chip-Seq_JUKART_Human1.08051884
117* VDR_24763502_ChIP-Seq_THP-1_Human1.07879770
118CIITA_25753668_ChIP-Seq_RAJI_Human1.07116178
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.06527084
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04875343
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02994244
122TFEB_21752829_ChIP-Seq_HELA_Human1.02637886
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02161795
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00016988
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99893850
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99587200
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98940660
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98641623
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97605908
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95614532
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94299379
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93518260
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.92808584
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92602373
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91136387
136FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87958215
137GATA3_26560356_Chip-Seq_TH1_Human0.87841850
138SMRT_27268052_Chip-Seq_Bcells_Human0.85328755
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.84539517
140RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84416120
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80745170
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.79299731
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78416583
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78062423
145BCL6_27268052_Chip-Seq_Bcells_Human0.77082550
146NCOR1_26117541_ChIP-Seq_K562_Human0.76905350
147GATA1_19941826_ChIP-Seq_K562_Human0.74150709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.41097359
2MP0002396_abnormal_hematopoietic_system2.77431188
3MP0006054_spinal_hemorrhage2.65381837
4MP0002139_abnormal_hepatobiliary_system2.39097782
5MP0001835_abnormal_antigen_presentation2.35442308
6MP0005360_urolithiasis2.18569305
7MP0003656_abnormal_erythrocyte_physiolo2.17062838
8MP0003693_abnormal_embryo_hatching1.91169182
9MP0003806_abnormal_nucleotide_metabolis1.87674645
10MP0008438_abnormal_cutaneous_collagen1.80009082
11MP0009785_altered_susceptibility_to1.77946465
12MP0005310_abnormal_salivary_gland1.72089640
13MP0003436_decreased_susceptibility_to1.68995449
14MP0010094_abnormal_chromosome_stability1.62689932
15MP0003186_abnormal_redox_activity1.62547303
16MP0005085_abnormal_gallbladder_physiolo1.62381715
17MP0003866_abnormal_defecation1.61788208
18MP0003763_abnormal_thymus_physiology1.59849879
19MP0005671_abnormal_response_to1.59623771
20MP0001545_abnormal_hematopoietic_system1.58682223
21MP0005397_hematopoietic_system_phenotyp1.58682223
22MP0000685_abnormal_immune_system1.57462209
23MP0005365_abnormal_bile_salt1.56764062
24MP0002166_altered_tumor_susceptibility1.54762228
25MP0004808_abnormal_hematopoietic_stem1.49875227
26MP0001800_abnormal_humoral_immune1.49774927
27MP0009840_abnormal_foam_cell1.47572843
28MP0003724_increased_susceptibility_to1.46992256
29MP0008260_abnormal_autophagy1.46936288
30MP0002419_abnormal_innate_immunity1.46596966
31MP0008875_abnormal_xenobiotic_pharmacok1.46216963
32MP0002398_abnormal_bone_marrow1.45693080
33MP0002452_abnormal_antigen_presenting1.43451563
34MP0005464_abnormal_platelet_physiology1.42231094
35MP0003646_muscle_fatigue1.39121309
36MP0005025_abnormal_response_to1.38897073
37MP0000689_abnormal_spleen_morphology1.37272516
38MP0002148_abnormal_hypersensitivity_rea1.36497584
39MP0009333_abnormal_splenocyte_physiolog1.36335564
40MP0005000_abnormal_immune_tolerance1.35837028
41MP0004381_abnormal_hair_follicle1.34589570
42MP0004957_abnormal_blastocyst_morpholog1.34506495
43MP0003221_abnormal_cardiomyocyte_apopto1.34339662
44MP0003077_abnormal_cell_cycle1.33913854
45MP0000465_gastrointestinal_hemorrhage1.33655805
46MP0003828_pulmonary_edema1.32247064
47MP0002722_abnormal_immune_system1.30884124
48MP0002420_abnormal_adaptive_immunity1.30342453
49MP0001851_eye_inflammation1.29699042
50MP0002723_abnormal_immune_serum1.29386283
51MP0001819_abnormal_immune_cell1.28157591
52MP0008007_abnormal_cellular_replicative1.27037368
53MP0000716_abnormal_immune_system1.23143292
54MP0005451_abnormal_body_composition1.21064659
55MP0001853_heart_inflammation1.20262919
56MP0005387_immune_system_phenotype1.18688186
57MP0001790_abnormal_immune_system1.18688186
58MP0008057_abnormal_DNA_replication1.18481583
59MP0000343_altered_response_to1.18447812
60MP0002277_abnormal_respiratory_mucosa1.17896154
61MP0004084_abnormal_cardiac_muscle1.17377019
62MP0004147_increased_porphyrin_level1.16954067
63MP0002429_abnormal_blood_cell1.16790219
64MP0008469_abnormal_protein_level1.15772448
65MP0002138_abnormal_hepatobiliary_system1.15766531
66MP0002933_joint_inflammation1.14717437
67MP0003111_abnormal_nucleus_morphology1.14395984
68MP0002006_tumorigenesis1.14294642
69MP0001845_abnormal_inflammatory_respons1.13880329
70MP0002019_abnormal_tumor_incidence1.12618619
71MP0010155_abnormal_intestine_physiology1.12125139
72MP0006036_abnormal_mitochondrial_physio1.09561309
73MP0005319_abnormal_enzyme/_coenzyme1.09170864
74MP0001533_abnormal_skeleton_physiology1.08986345
75MP0003183_abnormal_peptide_metabolism1.08459807
76MP0010352_gastrointestinal_tract_polyps1.08179723
77MP0009697_abnormal_copulation1.07547465
78MP0000609_abnormal_liver_physiology1.07546576
79MP0000490_abnormal_crypts_of1.07255396
80MP0004883_abnormal_blood_vessel1.05707683
81MP0002132_abnormal_respiratory_system1.05698590
82MP0002405_respiratory_system_inflammati1.04523771
83MP0001873_stomach_inflammation1.03059515
84MP0003252_abnormal_bile_duct1.02366998
85MP0009278_abnormal_bone_marrow1.01243085
86MP0003191_abnormal_cellular_cholesterol1.00931705
87MP0010307_abnormal_tumor_latency1.00509154
88MP0002877_abnormal_melanocyte_morpholog0.99541245
89MP0005275_abnormal_skin_tensile0.99234090
90MP0002998_abnormal_bone_remodeling0.98460287
91MP0000598_abnormal_liver_morphology0.98396924
92MP0005058_abnormal_lysosome_morphology0.98207181
93MP0010368_abnormal_lymphatic_system0.95329667
94MP0010329_abnormal_lipoprotein_level0.94595551
95MP0005075_abnormal_melanosome_morpholog0.94555199
96MP0000703_abnormal_thymus_morphology0.93281330
97MP0003279_aneurysm0.92493088
98MP0006082_CNS_inflammation0.91207371
99MP0003300_gastrointestinal_ulcer0.90948621
100MP0003705_abnormal_hypodermis_morpholog0.90819058
101MP0009763_increased_sensitivity_to0.89550871
102MP0000749_muscle_degeneration0.89071133
103MP0004947_skin_inflammation0.88180089
104MP0005408_hypopigmentation0.87436668
105MP0001663_abnormal_digestive_system0.87202679
106MP0004510_myositis0.86971048
107MP0002009_preneoplasia0.86695851
108MP0000858_altered_metastatic_potential0.86380816
109MP0002837_dystrophic_cardiac_calcinosis0.85581973
110MP0005330_cardiomyopathy0.84410833
111MP0004036_abnormal_muscle_relaxation0.84364578
112MP0005023_abnormal_wound_healing0.83637395
113MP0009764_decreased_sensitivity_to0.82497175
114MP0005503_abnormal_tendon_morphology0.82176469
115MP0003566_abnormal_cell_adhesion0.81735297
116MP0005332_abnormal_amino_acid0.81205928
117MP0005166_decreased_susceptibility_to0.79722060
118MP0001348_abnormal_lacrimal_gland0.78397360
119MP0003172_abnormal_lysosome_physiology0.77881048
120MP0003045_fibrosis0.76858552
121MP0003448_altered_tumor_morphology0.73796906
122MP0000249_abnormal_blood_vessel0.71038803
123MP0005164_abnormal_response_to0.67579629
124MP0003075_altered_response_to0.65874156
125MP0000015_abnormal_ear_pigmentation0.62887495
126MP0009765_abnormal_xenobiotic_induced0.62173274
127MP0003091_abnormal_cell_migration0.59983985
128MP0001986_abnormal_taste_sensitivity0.59089440
129MP0008004_abnormal_stomach_pH0.57639205
130MP0002928_abnormal_bile_duct0.57485998
131MP0005390_skeleton_phenotype0.55924568
132MP0008961_abnormal_basal_metabolism0.53496964
133MP0003795_abnormal_bone_structure0.52079186
134MP0000569_abnormal_digit_pigmentation0.51364108
135MP0002693_abnormal_pancreas_physiology0.49910425
136MP0008877_abnormal_DNA_methylation0.48452579
137MP0003690_abnormal_glial_cell0.45848627
138MP0008874_decreased_physiological_sensi0.44819061
139MP0000313_abnormal_cell_death0.43565535
140MP0009115_abnormal_fat_cell0.43229175

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)5.18425545
2Retrobulbar optic neuritis (HP:0100654)4.70092439
3Optic neuritis (HP:0100653)4.70092439
4Meningitis (HP:0001287)4.60420795
5Stomatitis (HP:0010280)4.53805812
6Recurrent cutaneous fungal infections (HP:0011370)4.30066930
7Chronic mucocutaneous candidiasis (HP:0002728)4.30066930
8Vasculitis (HP:0002633)4.27649363
9Panhypogammaglobulinemia (HP:0003139)4.27402041
10Abnormality of macrophages (HP:0004311)4.24826914
11Mediastinal lymphadenopathy (HP:0100721)4.24743331
12Encephalitis (HP:0002383)4.01405709
13Agammaglobulinemia (HP:0004432)3.85877413
14Thrombocytosis (HP:0001894)3.73626396
15Increased IgM level (HP:0003496)3.72823527
16Obstructive lung disease (HP:0006536)3.70580860
17Chronic obstructive pulmonary disease (HP:0006510)3.70580860
18Recurrent skin infections (HP:0001581)3.65588686
19Spontaneous hematomas (HP:0007420)3.55421698
20Pulmonary infiltrates (HP:0002113)3.53331142
21Increased IgE level (HP:0003212)3.43743551
22Lymphopenia (HP:0001888)3.41116269
23Keratoconjunctivitis sicca (HP:0001097)3.37818499
24Leukocytosis (HP:0001974)3.36167749
25Abnormality of cells of the lymphoid lineage (HP:0012140)3.30797370
26Hemoptysis (HP:0002105)3.20107623
27Granulocytopenia (HP:0001913)3.18728548
28Keratoconjunctivitis (HP:0001096)3.10808118
29Recurrent sinusitis (HP:0011108)3.06298396
30Pustule (HP:0200039)3.04098987
31Eosinophilia (HP:0001880)3.00567869
32Petechiae (HP:0000967)3.00030366
33Gingivitis (HP:0000230)2.99932398
34Urticaria (HP:0001025)2.98254958
35Hypergammaglobulinemia (HP:0010702)2.91853679
36Chest pain (HP:0100749)2.91354425
37Inflammation of the large intestine (HP:0002037)2.90259060
38Colitis (HP:0002583)2.86282709
39Abnormality of eosinophils (HP:0001879)2.83505551
40Severe combined immunodeficiency (HP:0004430)2.80172726
41Gastrointestinal inflammation (HP:0004386)2.79504570
42Aplastic anemia (HP:0001915)2.69941877
43Verrucae (HP:0200043)2.62567766
44Papilloma (HP:0012740)2.62567766
45Autoimmune thrombocytopenia (HP:0001973)2.60278985
46Hypochromic anemia (HP:0001931)2.60094738
47IgM deficiency (HP:0002850)2.59074511
48Pulmonary embolism (HP:0002204)2.58532424
49Chronic diarrhea (HP:0002028)2.53020445
50Prolonged bleeding time (HP:0003010)2.52737930
51Recurrent bacterial skin infections (HP:0005406)2.52274521
52Abnormality of fatty-acid metabolism (HP:0004359)2.51936947
53Elevated erythrocyte sedimentation rate (HP:0003565)2.50800798
54Osteomyelitis (HP:0002754)2.48467742
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45827912
56Recurrent viral infections (HP:0004429)2.45137552
57Myositis (HP:0100614)2.45007801
58Anorexia (HP:0002039)2.43188807
59Bronchitis (HP:0012387)2.42738843
60Osteolytic defects of the hand bones (HP:0009699)2.39914473
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.39914473
62Gangrene (HP:0100758)2.39641918
63IgA deficiency (HP:0002720)2.38690995
64Abnormality of the pleura (HP:0002103)2.38645630
65Lymphoma (HP:0002665)2.36719883
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35096509
67Restrictive lung disease (HP:0002091)2.34917181
68Multiple enchondromatosis (HP:0005701)2.34056578
69Abnormality of cells of the erythroid lineage (HP:0012130)2.33977153
70Abnormal number of erythroid precursors (HP:0012131)2.30876446
71Recurrent abscess formation (HP:0002722)2.30127682
72Increased muscle lipid content (HP:0009058)2.29773701
73Combined immunodeficiency (HP:0005387)2.29754578
74Hepatic necrosis (HP:0002605)2.28652536
75Rhabdomyolysis (HP:0003201)2.25053326
76Hypochromic microcytic anemia (HP:0004840)2.24755757
77Papilledema (HP:0001085)2.23918267
78Conjunctival hamartoma (HP:0100780)2.23322304
79Sepsis (HP:0100806)2.23232211
80Exertional dyspnea (HP:0002875)2.22131129
81Mucosal telangiectasiae (HP:0100579)2.22113159
82Joint swelling (HP:0001386)2.20916397
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19675620
84Intrahepatic cholestasis (HP:0001406)2.18583723
85Recurrent bronchitis (HP:0002837)2.18223232
86Polyneuropathy (HP:0001271)2.18114114
87Abnormality of T cell physiology (HP:0011840)2.17325388
88Lipid accumulation in hepatocytes (HP:0006561)2.15955873
89Recurrent pneumonia (HP:0006532)2.15334528
90Skin rash (HP:0000988)2.14283236
91Reticulocytopenia (HP:0001896)2.13742184
92Emphysema (HP:0002097)2.13096652
93Recurrent lower respiratory tract infections (HP:0002783)2.12914663
94Microcytic anemia (HP:0001935)2.12490363
95Increased intramyocellular lipid droplets (HP:0012240)2.11527955
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10858051
97Abnormality of alanine metabolism (HP:0010916)2.10858051
98Hyperalaninemia (HP:0003348)2.10858051
99Glomerulopathy (HP:0100820)2.10443802
100Abnormal platelet volume (HP:0011876)2.09665185
101Chronic otitis media (HP:0000389)2.07626447
102Deep venous thrombosis (HP:0002625)2.06798270
103Respiratory difficulties (HP:0002880)2.06506353
104Viral hepatitis (HP:0006562)2.06336274
105Vertebral compression fractures (HP:0002953)2.06089760
106Skin ulcer (HP:0200042)2.05726168
107Hypobetalipoproteinemia (HP:0003563)2.05707231
108Nonimmune hydrops fetalis (HP:0001790)2.05398996
109Impaired platelet aggregation (HP:0003540)2.03071577
110Abnormal platelet function (HP:0011869)2.03071577
111Abnormality of the prostate (HP:0008775)2.02772094
112Increased mean platelet volume (HP:0011877)2.02624669
113Generalized aminoaciduria (HP:0002909)2.01767176
114Hyperbilirubinemia (HP:0002904)2.00502358
115Nausea (HP:0002018)2.00367453
116Basal cell carcinoma (HP:0002671)1.98358465
117Fatigue (HP:0012378)1.97122073
118Arthralgia (HP:0002829)1.96268636
119Protrusio acetabuli (HP:0003179)1.95909856
120Abnormality of T cells (HP:0002843)1.94404807
121Abnormality of lateral ventricle (HP:0030047)1.94177062
122Abnormal cartilage morphology (HP:0002763)1.93832927
123Peritonitis (HP:0002586)1.93604409
124Cellulitis (HP:0100658)1.91110537
125Abnormality of T cell number (HP:0011839)1.90444453
126Xanthomatosis (HP:0000991)1.89970835
127Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89898450
128Dicarboxylic aciduria (HP:0003215)1.89898450
129Hepatocellular necrosis (HP:0001404)1.89065237
130Cervical subluxation (HP:0003308)1.88356614
131Lipoatrophy (HP:0100578)1.88036314
132Gastrointestinal infarctions (HP:0005244)1.87884745
133Epistaxis (HP:0000421)1.86967029
134Reduced antithrombin III activity (HP:0001976)1.86213687
135Increased hepatocellular lipid droplets (HP:0006565)1.85908344
136Purpura (HP:0000979)1.85513392
137Hypoglycemic coma (HP:0001325)1.84751499
138Exercise-induced muscle cramps (HP:0003710)1.84463621
139Acute myeloid leukemia (HP:0004808)1.84216691
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.82871944
141Myocardial infarction (HP:0001658)1.82245942
142IgG deficiency (HP:0004315)1.78362842
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76975696
144Beaking of vertebral bodies (HP:0004568)1.76917236
145Gastrointestinal stroma tumor (HP:0100723)1.75727786
146Gingival bleeding (HP:0000225)1.75464299
147Abnormality of methionine metabolism (HP:0010901)1.74698486
148B lymphocytopenia (HP:0010976)1.74519846
149Abnormality of B cell number (HP:0010975)1.74519846
150Recurrent gram-negative bacterial infections (HP:0005420)1.72676562
151Abnormality of iron homeostasis (HP:0011031)1.72591843
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71687566
153Thrombophlebitis (HP:0004418)1.71415455
154Neoplasm of head and neck (HP:0012288)1.71120978
155Esophageal neoplasm (HP:0100751)1.71120978
156Increased serum ferritin (HP:0003281)1.70022526
157Conjunctival telangiectasia (HP:0000524)1.69784247
158T lymphocytopenia (HP:0005403)1.68773380
159Increased serum pyruvate (HP:0003542)1.68601507
160Abnormality of glycolysis (HP:0004366)1.68601507
161Ankle contracture (HP:0006466)1.66719549
162Eczematoid dermatitis (HP:0000976)1.65978186
163Hyperammonemia (HP:0001987)1.65744711
164Abnormality of the common coagulation pathway (HP:0010990)1.65254778
165Cupped ribs (HP:0000887)1.65016507
166Arterial thrombosis (HP:0004420)1.64915244
167Myoglobinuria (HP:0002913)1.63537916
168Autoimmune hemolytic anemia (HP:0001890)1.62546435
169Poor head control (HP:0002421)1.62527762
170Orchitis (HP:0100796)1.61723428
171Recurrent fungal infections (HP:0002841)1.61184626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.44665600
2ACVR1B3.01511369
3PRPF4B3.00952308
4NME22.93003365
5FES2.70538259
6CSK2.56686117
7BRSK22.50631887
8PIM22.27794633
9STK102.21950292
10EEF2K2.19156012
11TAOK32.12780305
12TYK22.10444172
13WEE12.09202419
14MAP2K32.02644342
15NEK91.99937846
16MAP4K11.91821896
17BUB11.87698139
18CDC71.84922985
19TGFBR11.76823408
20HCK1.76269370
21KIT1.69893029
22LRRK21.69810383
23PKN21.69447817
24RPS6KA41.66815631
25TNK21.64700196
26TTN1.64399435
27FLT31.62082625
28JAK31.62035663
29TRPM71.57688794
30ARAF1.54356149
31STK241.53950997
32BCKDK1.53392258
33RAF11.52122081
34EIF2AK11.51866928
35TRIB31.51359937
36TEC1.50084791
37MST41.47317375
38MAP3K31.44690196
39SIK31.41522787
40TBK11.36559534
41SCYL21.34109108
42ERN11.32868680
43ZAP701.30457052
44BMPR1B1.30377052
45FGFR41.25531457
46EPHB11.24269794
47MARK31.24145701
48PLK41.23205810
49MAP3K81.21019436
50MAP3K141.18060218
51BMPR21.17942418
52STK41.17665256
53STK31.16992537
54MAP3K131.13530941
55CSF1R1.13460565
56CCNB11.13214941
57BTK1.13070128
58IRAK11.12642113
59FGR1.11621883
60RPS6KB21.08944651
61MAP3K61.08833817
62PRKCQ1.07383274
63SIK21.01803088
64FGFR31.00913499
65VRK10.97588285
66PIM10.97326458
67MATK0.96483875
68EIF2AK30.95681522
69YES10.95625643
70BRSK10.92017934
71MAPK110.90858553
72MAP3K50.89212432
73IRAK20.89013039
74IRAK40.88350231
75AURKB0.86415294
76KSR20.85838864
77MUSK0.84328902
78ILK0.83612707
79NEK20.82140549
80SYK0.80753496
81CDK40.80540740
82ABL20.77967102
83JAK10.77626861
84NLK0.77187571
85PDK10.77017072
86CAMKK20.76488369
87MYLK0.76082710
88MAP3K10.75817862
89MAPK70.75763017
90TGFBR20.74960794
91TAOK10.73679008
92BLK0.73052208
93CDK190.70984275
94OBSCN0.69372582
95IKBKB0.69261360
96ZAK0.68886229
97MAPKAPK50.68638873
98CAMKK10.67705874
99ITK0.66763143
100MAPK120.65755105
101MAPKAPK30.62528682
102PRKCH0.62482411
103KDR0.59854614
104MAP3K110.59754356
105CDK60.58447884
106NUAK10.58190035
107TXK0.57910965
108NEK10.57589807
109CDC42BPA0.57562016
110CLK10.56809216
111MELK0.56671828
112PLK10.56088943
113JAK20.54436395
114LYN0.53821378
115STK160.53095195
116TIE10.52393438
117FRK0.52149552
118FYN0.51215047
119RIPK10.51117447
120TTK0.48539949
121HIPK20.48488737
122MAP3K100.47945044
123BRAF0.47739786
124MARK20.47361298
125PRKD20.46547696
126PASK0.46098957
127PTK2B0.45932912
128MAP3K70.45887603
129TAOK20.44767262
130PIK3CG0.44384839
131MAPK40.43801286
132DYRK30.43772434
133CHUK0.42696970
134PBK0.42145774
135LCK0.42034952
136ATR0.41085502
137IKBKE0.40975692
138CDK80.39860028
139GRK60.39576047
140MOS0.39529474
141PDPK10.35919275
142SGK20.35735064
143MAPKAPK20.32823074
144EPHA30.29472943
145TYRO30.28795670
146NEK60.26310190
147SGK30.25846262
148EGFR0.25271700
149STK110.24787530
150RPS6KL10.22766774
151RPS6KC10.22766774
152CDK120.20074310
153MAP2K20.19752705
154SMG10.19706061

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.49188794
2Graft-versus-host disease_Homo sapiens_hsa053323.32042332
3Autoimmune thyroid disease_Homo sapiens_hsa053203.29146135
4DNA replication_Homo sapiens_hsa030303.15658599
5Type I diabetes mellitus_Homo sapiens_hsa049402.45807971
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35031054
7Asthma_Homo sapiens_hsa053102.34009790
8T cell receptor signaling pathway_Homo sapiens_hsa046602.13735694
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12607358
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08563181
11Base excision repair_Homo sapiens_hsa034102.05640146
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02663545
13Caffeine metabolism_Homo sapiens_hsa002321.87989881
14Ribosome_Homo sapiens_hsa030101.87043176
15Tuberculosis_Homo sapiens_hsa051521.84479617
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.82535677
17Mismatch repair_Homo sapiens_hsa034301.75323426
18Fatty acid degradation_Homo sapiens_hsa000711.71495628
19One carbon pool by folate_Homo sapiens_hsa006701.65999795
20Cell cycle_Homo sapiens_hsa041101.58677357
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57928399
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57171400
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55706908
24Acute myeloid leukemia_Homo sapiens_hsa052211.55499738
25Pyrimidine metabolism_Homo sapiens_hsa002401.47320356
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45663270
27Folate biosynthesis_Homo sapiens_hsa007901.43357024
28Homologous recombination_Homo sapiens_hsa034401.42946482
29Sulfur relay system_Homo sapiens_hsa041221.42432796
30Chemokine signaling pathway_Homo sapiens_hsa040621.41745424
31Propanoate metabolism_Homo sapiens_hsa006401.41300393
32Pentose phosphate pathway_Homo sapiens_hsa000301.39820273
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.37396847
34Proteasome_Homo sapiens_hsa030501.36941858
35Primary immunodeficiency_Homo sapiens_hsa053401.33316010
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32663701
37TNF signaling pathway_Homo sapiens_hsa046681.31138907
38Rheumatoid arthritis_Homo sapiens_hsa053231.30686189
39Carbon metabolism_Homo sapiens_hsa012001.30568795
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28438682
41Selenocompound metabolism_Homo sapiens_hsa004501.27042882
42RNA polymerase_Homo sapiens_hsa030201.26999074
43Peroxisome_Homo sapiens_hsa041461.24346294
44Nucleotide excision repair_Homo sapiens_hsa034201.24051854
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.16111869
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14722359
47Biosynthesis of amino acids_Homo sapiens_hsa012301.13622758
48RNA degradation_Homo sapiens_hsa030181.12953488
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12302575
50Antigen processing and presentation_Homo sapiens_hsa046121.10512277
51Non-small cell lung cancer_Homo sapiens_hsa052231.08985483
52Leishmaniasis_Homo sapiens_hsa051401.08026670
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07430680
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.06736040
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05261580
56Complement and coagulation cascades_Homo sapiens_hsa046101.05234662
57Protein export_Homo sapiens_hsa030601.04746891
58p53 signaling pathway_Homo sapiens_hsa041151.04205793
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.04124336
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03710963
61Measles_Homo sapiens_hsa051621.00476050
62Hepatitis C_Homo sapiens_hsa051600.99826338
63Herpes simplex infection_Homo sapiens_hsa051680.99112860
64Staphylococcus aureus infection_Homo sapiens_hsa051500.99016930
65Starch and sucrose metabolism_Homo sapiens_hsa005000.98950843
66Systemic lupus erythematosus_Homo sapiens_hsa053220.98110111
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94987858
68Legionellosis_Homo sapiens_hsa051340.94773218
69African trypanosomiasis_Homo sapiens_hsa051430.94263866
70Phagosome_Homo sapiens_hsa041450.93622499
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91779987
72HTLV-I infection_Homo sapiens_hsa051660.91199660
73Glutathione metabolism_Homo sapiens_hsa004800.89604182
74Tryptophan metabolism_Homo sapiens_hsa003800.89556920
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.88714942
76Chronic myeloid leukemia_Homo sapiens_hsa052200.87674273
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86931436
78Pyruvate metabolism_Homo sapiens_hsa006200.86875522
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86785527
80Platelet activation_Homo sapiens_hsa046110.86217333
81Non-homologous end-joining_Homo sapiens_hsa034500.85352178
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85160144
83Apoptosis_Homo sapiens_hsa042100.81594914
84Pertussis_Homo sapiens_hsa051330.79988481
85Renal cell carcinoma_Homo sapiens_hsa052110.79318446
86B cell receptor signaling pathway_Homo sapiens_hsa046620.79093054
87Vitamin B6 metabolism_Homo sapiens_hsa007500.77112719
88Fatty acid metabolism_Homo sapiens_hsa012120.76697153
89PPAR signaling pathway_Homo sapiens_hsa033200.76428391
90Chemical carcinogenesis_Homo sapiens_hsa052040.76161973
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75652790
92beta-Alanine metabolism_Homo sapiens_hsa004100.74892797
93Viral myocarditis_Homo sapiens_hsa054160.74080211
94Toxoplasmosis_Homo sapiens_hsa051450.73003327
95Prolactin signaling pathway_Homo sapiens_hsa049170.72894702
96Hepatitis B_Homo sapiens_hsa051610.72489409
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71453840
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71052337
99VEGF signaling pathway_Homo sapiens_hsa043700.70883274
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70744625
101Small cell lung cancer_Homo sapiens_hsa052220.70016298
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69980596
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.68878736
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68550988
105Pancreatic cancer_Homo sapiens_hsa052120.68304528
106Histidine metabolism_Homo sapiens_hsa003400.67862835
107Viral carcinogenesis_Homo sapiens_hsa052030.67319749
108Osteoclast differentiation_Homo sapiens_hsa043800.66381341
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66348489
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66175486
111Colorectal cancer_Homo sapiens_hsa052100.65623811
112RNA transport_Homo sapiens_hsa030130.65445201
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64049358
114Galactose metabolism_Homo sapiens_hsa000520.63224437
115Malaria_Homo sapiens_hsa051440.63057720
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61569799
117Spliceosome_Homo sapiens_hsa030400.61211378
118Retinol metabolism_Homo sapiens_hsa008300.60975147
119Purine metabolism_Homo sapiens_hsa002300.60780328
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60653184
121Arginine and proline metabolism_Homo sapiens_hsa003300.60102789
122Other glycan degradation_Homo sapiens_hsa005110.59695970
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58549123
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57391463
125FoxO signaling pathway_Homo sapiens_hsa040680.56090098
126Influenza A_Homo sapiens_hsa051640.56031490
127Arginine biosynthesis_Homo sapiens_hsa002200.53327341
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52671005
129Sulfur metabolism_Homo sapiens_hsa009200.52635505
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51840540
131Epstein-Barr virus infection_Homo sapiens_hsa051690.51251391
132Salmonella infection_Homo sapiens_hsa051320.51004896
133Choline metabolism in cancer_Homo sapiens_hsa052310.50064508
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.49788516
135Dorso-ventral axis formation_Homo sapiens_hsa043200.49550284
136MAPK signaling pathway_Homo sapiens_hsa040100.49018204
137Shigellosis_Homo sapiens_hsa051310.48320121
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47473807
139Hematopoietic cell lineage_Homo sapiens_hsa046400.46220605
140Endometrial cancer_Homo sapiens_hsa052130.46104172
141HIF-1 signaling pathway_Homo sapiens_hsa040660.45131092
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44052590
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.43086816
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42368502
145Prostate cancer_Homo sapiens_hsa052150.42145068
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.41798209
147Endocytosis_Homo sapiens_hsa041440.38106016
148Inositol phosphate metabolism_Homo sapiens_hsa005620.33136233
149Notch signaling pathway_Homo sapiens_hsa043300.33070660
150GnRH signaling pathway_Homo sapiens_hsa049120.32147662
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29855217
152ErbB signaling pathway_Homo sapiens_hsa040120.28032480
153mTOR signaling pathway_Homo sapiens_hsa041500.28013210
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27826933
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26961157
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.25735795
157Insulin resistance_Homo sapiens_hsa049310.24223693
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.23923886
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23524787
160Ras signaling pathway_Homo sapiens_hsa040140.23174307
161Amoebiasis_Homo sapiens_hsa051460.19535551
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17369198
163Glioma_Homo sapiens_hsa052140.15600806
164Regulation of autophagy_Homo sapiens_hsa041400.14289906
165Rap1 signaling pathway_Homo sapiens_hsa040150.13379603
166Long-term potentiation_Homo sapiens_hsa047200.13283187
167Estrogen signaling pathway_Homo sapiens_hsa049150.13011627

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