MSL3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.86442436
2CENP-A containing nucleosome assembly (GO:0034080)4.33858490
3formation of translation preinitiation complex (GO:0001731)4.32251783
4ribosomal small subunit assembly (GO:0000028)4.27424691
5chromatin remodeling at centromere (GO:0031055)4.27317720
6ribosomal large subunit biogenesis (GO:0042273)4.14712349
7telomere maintenance via semi-conservative replication (GO:0032201)3.93374187
8rRNA modification (GO:0000154)3.86017791
9ribosomal small subunit biogenesis (GO:0042274)3.82406102
10mitotic metaphase plate congression (GO:0007080)3.82260302
11proteasome assembly (GO:0043248)3.80874927
12DNA replication checkpoint (GO:0000076)3.80235037
13regulation of mitochondrial translation (GO:0070129)3.79017857
14DNA strand elongation involved in DNA replication (GO:0006271)3.78446974
15establishment of viral latency (GO:0019043)3.76254093
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74688628
17histone exchange (GO:0043486)3.72028880
18purine nucleobase biosynthetic process (GO:0009113)3.69839129
19translational termination (GO:0006415)3.68942619
20viral transcription (GO:0019083)3.66319897
21DNA strand elongation (GO:0022616)3.65791367
22chaperone-mediated protein transport (GO:0072321)3.59693100
23ribonucleoprotein complex biogenesis (GO:0022613)3.57390381
24rRNA methylation (GO:0031167)3.54795641
25telomere maintenance via recombination (GO:0000722)3.53888100
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.52955816
27mitotic recombination (GO:0006312)3.52702974
28metaphase plate congression (GO:0051310)3.52484686
29translational initiation (GO:0006413)3.52447643
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51597452
31cotranslational protein targeting to membrane (GO:0006613)3.47675518
32maturation of SSU-rRNA (GO:0030490)3.47629775
33kinetochore organization (GO:0051383)3.46681861
34ribosome assembly (GO:0042255)3.45203891
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44368114
36DNA replication-independent nucleosome assembly (GO:0006336)3.41269491
37DNA replication-independent nucleosome organization (GO:0034724)3.41269491
38protein targeting to ER (GO:0045047)3.41218122
39nucleobase biosynthetic process (GO:0046112)3.38019028
40IMP biosynthetic process (GO:0006188)3.36471560
41ribosome biogenesis (GO:0042254)3.35944430
42protein localization to kinetochore (GO:0034501)3.35573435
43DNA unwinding involved in DNA replication (GO:0006268)3.34659917
44resolution of meiotic recombination intermediates (GO:0000712)3.33301811
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32498888
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31255201
47translational elongation (GO:0006414)3.27888229
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27562984
49protein localization to endoplasmic reticulum (GO:0070972)3.25528191
50kinetochore assembly (GO:0051382)3.24141075
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23517827
52mitotic chromosome condensation (GO:0007076)3.22600918
53mitotic sister chromatid segregation (GO:0000070)3.22111108
54protein localization to chromosome, centromeric region (GO:0071459)3.21335753
55cullin deneddylation (GO:0010388)3.20522488
56translation (GO:0006412)3.19399314
57mitotic sister chromatid cohesion (GO:0007064)3.18916600
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.18148610
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14169017
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12918390
61tRNA aminoacylation for protein translation (GO:0006418)3.10634147
62protein K6-linked ubiquitination (GO:0085020)3.06680776
63transcription from mitochondrial promoter (GO:0006390)3.05997753
64cellular component biogenesis (GO:0044085)3.04935751
65negative regulation of ligase activity (GO:0051352)3.02456019
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02456019
67amino acid activation (GO:0043038)3.01826418
68tRNA aminoacylation (GO:0043039)3.01826418
69viral life cycle (GO:0019058)3.01416679
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00832022
71ATP synthesis coupled proton transport (GO:0015986)3.00832022
72transcription-coupled nucleotide-excision repair (GO:0006283)3.00337209
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99337793
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99337793
75sister chromatid segregation (GO:0000819)2.98413616
76rRNA processing (GO:0006364)2.96531876
77protein deneddylation (GO:0000338)2.95473318
78regulation of chromosome segregation (GO:0051983)2.95273562
79mitotic spindle checkpoint (GO:0071174)2.94756976
80spindle checkpoint (GO:0031577)2.93971467
81cellular protein complex disassembly (GO:0043624)2.92407802
82regulation of centriole replication (GO:0046599)2.92034474
83DNA catabolic process, exonucleolytic (GO:0000738)2.91045291
84nuclear pore complex assembly (GO:0051292)2.90686365
85DNA damage response, detection of DNA damage (GO:0042769)2.90639436
86spliceosomal snRNP assembly (GO:0000387)2.90079220
87mitotic nuclear envelope disassembly (GO:0007077)2.89558279
88synapsis (GO:0007129)2.88392816
89protein targeting to mitochondrion (GO:0006626)2.87456098
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86529690
91telomere maintenance via telomere lengthening (GO:0010833)2.86279221
927-methylguanosine mRNA capping (GO:0006370)2.86204931
93regulation of meiosis I (GO:0060631)2.85884390
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.85583268
95negative regulation of sister chromatid segregation (GO:0033046)2.85583268
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85583268
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85583268
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85583268
99IMP metabolic process (GO:0046040)2.85075495
100negative regulation of chromosome segregation (GO:0051985)2.83929162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75323313
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71563834
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11722322
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.06396368
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64975720
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.60878987
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.50126945
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39474481
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35467606
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20978800
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.97697655
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95405280
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92919090
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90894741
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83191431
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79493045
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79167264
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76143292
19ELK1_19687146_ChIP-ChIP_HELA_Human2.74892439
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63515536
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61666569
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60340802
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46119539
24AR_21909140_ChIP-Seq_LNCAP_Human2.45497718
25VDR_23849224_ChIP-Seq_CD4+_Human2.41604913
26DCP1A_22483619_ChIP-Seq_HELA_Human2.39814606
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33298803
28XRN2_22483619_ChIP-Seq_HELA_Human2.28264094
29TTF2_22483619_ChIP-Seq_HELA_Human2.24673896
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24049947
31FOXP3_21729870_ChIP-Seq_TREG_Human2.23367129
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21179178
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20770354
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12261342
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08867740
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97285424
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.95825323
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94659218
39GABP_19822575_ChIP-Seq_HepG2_Human1.93749960
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92665984
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.92368557
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86286682
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86197284
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83071869
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73967657
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70720167
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66730157
48MYC_18940864_ChIP-ChIP_HL60_Human1.63154965
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62775832
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.53348345
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53309731
52KDM5A_27292631_Chip-Seq_BREAST_Human1.36840115
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35108495
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34119919
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30184915
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28402661
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27122867
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25001183
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.20376792
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20214579
61VDR_22108803_ChIP-Seq_LS180_Human1.20196373
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.19640221
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16393560
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15882706
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.15357640
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14531061
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.14405366
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.13755368
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11503552
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.07807876
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07134664
72EWS_26573619_Chip-Seq_HEK293_Human1.05911142
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05773008
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05773008
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05773008
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00533492
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00176400
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00080130
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95399656
80KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95337499
81ELF5_23300383_ChIP-Seq_T47D_Human0.94944507
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94087666
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92672920
84TP63_19390658_ChIP-ChIP_HaCaT_Human0.90857392
85ZNF263_19887448_ChIP-Seq_K562_Human0.89571675
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89135641
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87150765
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84580915
89CIITA_25753668_ChIP-Seq_RAJI_Human0.81480534
90TFEB_21752829_ChIP-Seq_HELA_Human0.80729970
91ZNF274_21170338_ChIP-Seq_K562_Hela0.80168069
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80160219
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79093072
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78366090
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78140811
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76014929
97CHD1_26751641_Chip-Seq_LNCaP_Human0.75812687
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72836202
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70578968
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70525572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.83401894
2MP0008058_abnormal_DNA_repair4.29952303
3MP0004957_abnormal_blastocyst_morpholog4.20683379
4MP0010094_abnormal_chromosome_stability4.04567858
5MP0003077_abnormal_cell_cycle3.23300541
6MP0003111_abnormal_nucleus_morphology3.16058010
7MP0008932_abnormal_embryonic_tissue2.83399195
8MP0009697_abnormal_copulation2.66936088
9MP0010030_abnormal_orbit_morphology2.44051532
10MP0003718_maternal_effect2.39736726
11MP0006292_abnormal_olfactory_placode2.27575725
12MP0008007_abnormal_cellular_replicative2.25080802
13MP0003941_abnormal_skin_development2.22586493
14MP0008057_abnormal_DNA_replication2.21400923
15MP0003786_premature_aging2.10607086
16MP0001293_anophthalmia2.06896201
17MP0006035_abnormal_mitochondrial_morpho2.03227319
18MP0002938_white_spotting1.99299608
19MP0009379_abnormal_foot_pigmentation1.84174317
20MP0001730_embryonic_growth_arrest1.78954378
21MP0003186_abnormal_redox_activity1.70249647
22MP0002210_abnormal_sex_determination1.68879763
23MP0000350_abnormal_cell_proliferation1.64217158
24MP0001697_abnormal_embryo_size1.63087376
25MP0003890_abnormal_embryonic-extraembry1.61831297
26MP0008877_abnormal_DNA_methylation1.55096603
27MP0005380_embryogenesis_phenotype1.51509579
28MP0001672_abnormal_embryogenesis/_devel1.51509579
29MP0003315_abnormal_perineum_morphology1.51019823
30MP0000358_abnormal_cell_content/1.47935992
31MP0001929_abnormal_gametogenesis1.47389357
32MP0002085_abnormal_embryonic_tissue1.47120475
33MP0008789_abnormal_olfactory_epithelium1.42200650
34MP0000647_abnormal_sebaceous_gland1.41433451
35MP0002084_abnormal_developmental_patter1.41422464
36MP0003937_abnormal_limbs/digits/tail_de1.41244092
37MP0008995_early_reproductive_senescence1.41060939
38MP0002080_prenatal_lethality1.38578100
39MP0005075_abnormal_melanosome_morpholog1.38236557
40MP0003136_yellow_coat_color1.35986919
41MP0003123_paternal_imprinting1.35010658
42MP0006036_abnormal_mitochondrial_physio1.31092405
43MP0001145_abnormal_male_reproductive1.30983834
44MP0003984_embryonic_growth_retardation1.29877359
45MP0000372_irregular_coat_pigmentation1.29815829
46MP0002088_abnormal_embryonic_growth/wei1.29223029
47MP0001286_abnormal_eye_development1.28879823
48MP0000653_abnormal_sex_gland1.25059407
49MP0000313_abnormal_cell_death1.16181253
50MP0009672_abnormal_birth_weight1.15949266
51MP0001529_abnormal_vocalization1.15925423
52MP0000566_synostosis1.13849876
53MP0002697_abnormal_eye_size1.12798430
54MP0002796_impaired_skin_barrier1.08668400
55MP0002234_abnormal_pharynx_morphology1.07834431
56MP0002233_abnormal_nose_morphology1.06317916
57MP0003698_abnormal_male_reproductive1.05304869
58MP0003806_abnormal_nucleotide_metabolis1.04349000
59MP0004197_abnormal_fetal_growth/weight/1.01162987
60MP0005501_abnormal_skin_physiology1.00838261
61MP0002111_abnormal_tail_morphology1.00164365
62MP0005394_taste/olfaction_phenotype0.97980074
63MP0005499_abnormal_olfactory_system0.97980074
64MP0003119_abnormal_digestive_system0.95694857
65MP0003567_abnormal_fetal_cardiomyocyte0.95680537
66MP0000537_abnormal_urethra_morphology0.93662206
67MP0005410_abnormal_fertilization0.93584890
68MP0001119_abnormal_female_reproductive0.93366064
69MP0008260_abnormal_autophagy0.91451362
70MP0000579_abnormal_nail_morphology0.89444980
71MP0003936_abnormal_reproductive_system0.85359013
72MP0009703_decreased_birth_body0.85193979
73MP0002086_abnormal_extraembryonic_tissu0.85091843
74MP0002160_abnormal_reproductive_system0.83870651
75MP0006072_abnormal_retinal_apoptosis0.83704007
76MP0005367_renal/urinary_system_phenotyp0.83450890
77MP0000516_abnormal_urinary_system0.83450890
78MP0003755_abnormal_palate_morphology0.77684448
79MP0002161_abnormal_fertility/fecundity0.77586184
80MP0001727_abnormal_embryo_implantation0.77304055
81MP0005408_hypopigmentation0.76601693
82MP0000049_abnormal_middle_ear0.75465221
83MP0003942_abnormal_urinary_system0.73740182
84MP0002751_abnormal_autonomic_nervous0.72624389
85MP0010307_abnormal_tumor_latency0.72453269
86MP0005084_abnormal_gallbladder_morpholo0.71236559
87MP0003699_abnormal_female_reproductive0.71214345
88MP0009053_abnormal_anal_canal0.71058665
89MP0002736_abnormal_nociception_after0.70759825
90MP0003943_abnormal_hepatobiliary_system0.69768936
91MP0003861_abnormal_nervous_system0.69768679
92MP0001340_abnormal_eyelid_morphology0.69255102
93MP0003935_abnormal_craniofacial_develop0.67976974
94MP0001661_extended_life_span0.66210978
95MP0010352_gastrointestinal_tract_polyps0.65026096
96MP0005395_other_phenotype0.63133622
97MP0002177_abnormal_outer_ear0.62965219
98MP0001881_abnormal_mammary_gland0.62335913
99MP0000627_abnormal_mammary_gland0.62171615
100MP0002092_abnormal_eye_morphology0.62124276

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.21433113
2Chromsome breakage (HP:0040012)3.99188760
3Reticulocytopenia (HP:0001896)3.97320770
4Increased hepatocellular lipid droplets (HP:0006565)3.64738525
5Abnormality of the preputium (HP:0100587)3.41930774
6Meckel diverticulum (HP:0002245)3.36691762
7Lipid accumulation in hepatocytes (HP:0006561)3.32978291
8Acute necrotizing encephalopathy (HP:0006965)3.31186837
9Acute encephalopathy (HP:0006846)3.30447675
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.23982102
11Abnormality of the ileum (HP:0001549)3.15081170
12Abnormal mitochondria in muscle tissue (HP:0008316)3.10215386
13Abnormality of chromosome stability (HP:0003220)3.05001631
14Increased CSF lactate (HP:0002490)2.87612002
15Mitochondrial inheritance (HP:0001427)2.85793534
16Abnormality of cells of the erythroid lineage (HP:0012130)2.84023471
17Small intestinal stenosis (HP:0012848)2.83840954
18Duodenal stenosis (HP:0100867)2.83840954
19Macrocytic anemia (HP:0001972)2.80842153
20Abnormal number of erythroid precursors (HP:0012131)2.73471314
21Absent thumb (HP:0009777)2.72957687
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70828418
23Degeneration of anterior horn cells (HP:0002398)2.69957497
24Abnormality of the anterior horn cell (HP:0006802)2.69957497
25Abnormal lung lobation (HP:0002101)2.67626452
26Renal Fanconi syndrome (HP:0001994)2.65784216
27Microvesicular hepatic steatosis (HP:0001414)2.64615491
28Hepatocellular necrosis (HP:0001404)2.62168429
29Cerebral edema (HP:0002181)2.59487249
30Progressive macrocephaly (HP:0004481)2.55088275
31Abnormality of the labia minora (HP:0012880)2.44383483
32Horseshoe kidney (HP:0000085)2.38872991
33Abnormality of the duodenum (HP:0002246)2.35627403
34Abnormality of methionine metabolism (HP:0010901)2.34933088
35Triphalangeal thumb (HP:0001199)2.32899652
36Reduced antithrombin III activity (HP:0001976)2.31048188
37Type I transferrin isoform profile (HP:0003642)2.29959824
38Microglossia (HP:0000171)2.28957341
39Hepatic necrosis (HP:0002605)2.28305462
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28260633
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28260633
42Increased serum lactate (HP:0002151)2.26772042
43Myelodysplasia (HP:0002863)2.24954993
44Pallor (HP:0000980)2.19381147
45Sparse eyelashes (HP:0000653)2.16937374
46Increased intramyocellular lipid droplets (HP:0012240)2.16656392
47Lactic acidosis (HP:0003128)2.14794984
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14559430
49Abnormal protein N-linked glycosylation (HP:0012347)2.14559430
50Abnormal protein glycosylation (HP:0012346)2.14559430
51Abnormal glycosylation (HP:0012345)2.14559430
52Abnormality of the carotid arteries (HP:0005344)2.14455268
53Birth length less than 3rd percentile (HP:0003561)2.13852927
54Aplastic anemia (HP:0001915)2.09398069
55Cortical dysplasia (HP:0002539)2.02949878
56Sclerocornea (HP:0000647)2.01752553
57Hyperglycinemia (HP:0002154)2.00612451
58Abnormal hair whorl (HP:0010721)1.97861419
59Multiple enchondromatosis (HP:0005701)1.96668183
60Exercise intolerance (HP:0003546)1.96603923
61Volvulus (HP:0002580)1.94708285
62Sloping forehead (HP:0000340)1.93231506
63Abnormality of serum amino acid levels (HP:0003112)1.87526888
64Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86809963
65Colon cancer (HP:0003003)1.86225840
66Atrophy/Degeneration involving motor neurons (HP:0007373)1.85565931
67Abnormality of renal resorption (HP:0011038)1.85348361
68Respiratory difficulties (HP:0002880)1.85289082
69Exertional dyspnea (HP:0002875)1.84360901
70Nephroblastoma (Wilms tumor) (HP:0002667)1.84096842
713-Methylglutaconic aciduria (HP:0003535)1.82608166
72Septate vagina (HP:0001153)1.82456071
73Pancreatic fibrosis (HP:0100732)1.82327368
74Short tibia (HP:0005736)1.80030079
75Increased serum pyruvate (HP:0003542)1.79853127
76Testicular atrophy (HP:0000029)1.77073000
77Choanal atresia (HP:0000453)1.75058313
78Abnormality of reticulocytes (HP:0004312)1.73247418
79Increased nuchal translucency (HP:0010880)1.72895243
80Facial cleft (HP:0002006)1.72636956
81Abnormality of glycolysis (HP:0004366)1.72198774
82Absent radius (HP:0003974)1.71876225
83Pancytopenia (HP:0001876)1.71558559
84Median cleft lip (HP:0000161)1.70969994
85Embryonal renal neoplasm (HP:0011794)1.70775937
86Concave nail (HP:0001598)1.69359037
87Respiratory failure (HP:0002878)1.69306235
88Clubbing of toes (HP:0100760)1.69179618
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68742926
90Hyperglycinuria (HP:0003108)1.68148961
91Increased muscle lipid content (HP:0009058)1.67988787
92Abnormal spermatogenesis (HP:0008669)1.66905523
93Stenosis of the external auditory canal (HP:0000402)1.66203042
94CNS hypomyelination (HP:0003429)1.66097851
95Cerebral hypomyelination (HP:0006808)1.65821634
96Abnormality of DNA repair (HP:0003254)1.65182195
97Postnatal microcephaly (HP:0005484)1.62191049
98Preaxial hand polydactyly (HP:0001177)1.61992903
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.61806031
100Abnormality of homocysteine metabolism (HP:0010919)1.61335255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.45971249
2PBK3.67769458
3VRK23.29246152
4SRPK13.05350951
5TTK3.04971887
6CDC72.85766837
7NEK12.70751676
8PLK42.70365077
9MST42.70102374
10STK162.69317366
11BRSK22.54203859
12NME12.47396341
13EIF2AK12.37557643
14WEE12.29024841
15ZAK2.12883621
16TRIM282.07035686
17TSSK61.93595517
18EIF2AK31.91199092
19NME21.90184094
20PLK31.87619892
21TAF11.64360974
22NUAK11.63750057
23PLK11.61202265
24MAP3K121.48130829
25VRK11.47275773
26BRSK11.45827176
27ACVR1B1.45613157
28TESK21.44731774
29MKNK11.41886707
30MST1R1.39849100
31TNIK1.32886697
32NEK21.29328763
33AURKB1.28542713
34PASK1.26948222
35EPHA21.25292427
36CHEK21.24314054
37CDK191.21878480
38ERBB31.17099767
39DYRK31.13967927
40SCYL21.06863503
41ATR1.06842433
42CDK71.06242270
43TESK11.03082151
44MKNK21.01934016
45AURKA1.00243397
46RPS6KB20.96386429
47PNCK0.96136533
48BCKDK0.91871271
49ERBB40.89625060
50BCR0.89280948
51CDK80.88866850
52EIF2AK20.88720647
53RPS6KA40.85257364
54PAK40.85252372
55LIMK10.83853728
56STK30.80999337
57RAF10.80343394
58CHEK10.76655201
59BRAF0.74958418
60MAP3K80.71132187
61PRKCI0.71082712
62ATM0.70668409
63BMPR1B0.65450054
64CSNK2A20.64039628
65CLK10.63591443
66ILK0.60805897
67DYRK20.60437080
68CCNB10.59363084
69CSNK2A10.58043432
70WNK30.52830932
71STK40.49773879
72STK38L0.47580360
73STK100.46917749
74CSNK1G10.46383015
75MAP3K20.43240286
76CDK10.43049146
77PAK10.42473607
78MAP2K70.42191974
79MET0.41651676
80FGFR10.40634153
81PIM20.40362703
82WNK40.39715628
83CSNK1E0.38710293
84CDK30.38235228
85CDK20.36490815
86ARAF0.35176823
87KDR0.34875635
88STK390.31999947
89MAP4K20.30668649
90TGFBR10.30038205
91BMX0.28754667
92ABL20.28291050
93MINK10.28286264
94LRRK20.27027899
95PLK20.25919566
96PRKDC0.25361591
97KSR10.25221402
98STK240.24959850
99DAPK10.23874802
100RPS6KA50.23256497

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.74886742
2Ribosome_Homo sapiens_hsa030103.73358218
3Mismatch repair_Homo sapiens_hsa034303.65968126
4Proteasome_Homo sapiens_hsa030503.53769655
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14670530
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75800960
7Homologous recombination_Homo sapiens_hsa034402.66685657
8Nucleotide excision repair_Homo sapiens_hsa034202.55722067
9RNA transport_Homo sapiens_hsa030132.52998081
10RNA polymerase_Homo sapiens_hsa030202.49438583
11Fanconi anemia pathway_Homo sapiens_hsa034602.49434732
12Base excision repair_Homo sapiens_hsa034102.46493909
13Basal transcription factors_Homo sapiens_hsa030222.42526018
14Protein export_Homo sapiens_hsa030602.39784039
15Oxidative phosphorylation_Homo sapiens_hsa001902.32193037
16Spliceosome_Homo sapiens_hsa030402.31756686
17Parkinsons disease_Homo sapiens_hsa050122.12973602
18Non-homologous end-joining_Homo sapiens_hsa034502.02175918
19Cell cycle_Homo sapiens_hsa041101.91939952
20Huntingtons disease_Homo sapiens_hsa050161.79622150
21One carbon pool by folate_Homo sapiens_hsa006701.79529590
22RNA degradation_Homo sapiens_hsa030181.72854657
23Pyrimidine metabolism_Homo sapiens_hsa002401.64225302
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54418995
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.52564941
26Pyruvate metabolism_Homo sapiens_hsa006201.45062502
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39597436
28Fatty acid elongation_Homo sapiens_hsa000621.35573832
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35370210
30mRNA surveillance pathway_Homo sapiens_hsa030151.31680275
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30331021
32Propanoate metabolism_Homo sapiens_hsa006401.29325209
33Steroid biosynthesis_Homo sapiens_hsa001001.28107980
34Alzheimers disease_Homo sapiens_hsa050101.24232741
35Biosynthesis of amino acids_Homo sapiens_hsa012301.21729407
36Purine metabolism_Homo sapiens_hsa002301.19530786
37Selenocompound metabolism_Homo sapiens_hsa004501.16823725
38Folate biosynthesis_Homo sapiens_hsa007901.15038029
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10942158
40Carbon metabolism_Homo sapiens_hsa012001.10615177
41Sulfur relay system_Homo sapiens_hsa041221.07120545
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06261552
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04557719
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01307129
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96505863
46Vitamin B6 metabolism_Homo sapiens_hsa007500.96203692
47Glutathione metabolism_Homo sapiens_hsa004800.95013051
48Oocyte meiosis_Homo sapiens_hsa041140.90700507
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86266705
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85755386
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81171467
52p53 signaling pathway_Homo sapiens_hsa041150.78553676
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78186226
54Sulfur metabolism_Homo sapiens_hsa009200.73926379
55Metabolic pathways_Homo sapiens_hsa011000.65862568
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65590956
57N-Glycan biosynthesis_Homo sapiens_hsa005100.64248236
58Pentose phosphate pathway_Homo sapiens_hsa000300.62560016
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61089559
60Regulation of autophagy_Homo sapiens_hsa041400.60766703
61Cardiac muscle contraction_Homo sapiens_hsa042600.59697732
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53573904
63Hedgehog signaling pathway_Homo sapiens_hsa043400.51264322
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50805580
65Thyroid cancer_Homo sapiens_hsa052160.50463915
66Basal cell carcinoma_Homo sapiens_hsa052170.50354769
67Fatty acid metabolism_Homo sapiens_hsa012120.47775084
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.46745873
69Fructose and mannose metabolism_Homo sapiens_hsa000510.45848611
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.44704683
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43726173
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43674453
73Hippo signaling pathway_Homo sapiens_hsa043900.38701645
74Peroxisome_Homo sapiens_hsa041460.37167379
75Epstein-Barr virus infection_Homo sapiens_hsa051690.36352679
76TGF-beta signaling pathway_Homo sapiens_hsa043500.36346685
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36108469
78Phototransduction_Homo sapiens_hsa047440.33423697
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33079865
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32526215
81Wnt signaling pathway_Homo sapiens_hsa043100.30825034
82Butanoate metabolism_Homo sapiens_hsa006500.28848585
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28105048
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26525677
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.25501529
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24456020
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23574570
88Tyrosine metabolism_Homo sapiens_hsa003500.22252440
89Arginine and proline metabolism_Homo sapiens_hsa003300.21987706
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.19601636
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.17970448
92Retinol metabolism_Homo sapiens_hsa008300.16995030
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15261848
94Viral carcinogenesis_Homo sapiens_hsa052030.11884982
95Galactose metabolism_Homo sapiens_hsa000520.10988458
96Olfactory transduction_Homo sapiens_hsa047400.10687367
97Vitamin digestion and absorption_Homo sapiens_hsa049770.10420807
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09845627
99Chemical carcinogenesis_Homo sapiens_hsa052040.08669180
100beta-Alanine metabolism_Homo sapiens_hsa004100.08525816

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