MSLNL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of chemical stimulus (GO:0007606)9.90060824
2DNA strand renaturation (GO:0000733)9.66120520
3GDP-mannose metabolic process (GO:0019673)9.57761570
4negative regulation of cell aging (GO:0090344)9.20030351
5protein polyglutamylation (GO:0018095)8.80775856
6protein insertion into membrane (GO:0051205)8.64327820
7meiotic chromosome segregation (GO:0045132)8.59965231
8adenosine receptor signaling pathway (GO:0001973)8.56780226
9regulation of cilium movement (GO:0003352)8.17755109
10rRNA methylation (GO:0031167)7.94144483
11regulation of skeletal muscle contraction (GO:0014819)7.81211568
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.69179795
13positive regulation of protein kinase C signaling (GO:0090037)7.38505748
14purinergic nucleotide receptor signaling pathway (GO:0035590)7.34643787
15adenine nucleotide transport (GO:0051503)7.26926035
16adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.04885319
17purine ribonucleotide transport (GO:0015868)7.03958508
18rRNA modification (GO:0000154)6.84443067
19lens fiber cell differentiation (GO:0070306)6.76474047
20phosphorelay signal transduction system (GO:0000160)6.44880839
21atrial cardiac muscle cell action potential (GO:0086014)6.30280894
22modulation by virus of host process (GO:0019054)6.10667278
23nucleotide transmembrane transport (GO:1901679)6.06095197
24response to ATP (GO:0033198)6.05352684
25detection of calcium ion (GO:0005513)5.96928684
26nucleoside transmembrane transport (GO:1901642)5.93682834
27protein localization to cilium (GO:0061512)5.88821067
28peptidyl-glutamic acid carboxylation (GO:0017187)5.78718647
29protein carboxylation (GO:0018214)5.78718647
30purine nucleotide transport (GO:0015865)5.67761028
31urinary tract smooth muscle contraction (GO:0014848)5.61626787
32negative regulation of cytosolic calcium ion concentration (GO:0051481)5.52485681
33UV protection (GO:0009650)5.34878836
34purinergic receptor signaling pathway (GO:0035587)5.33972754
35melanin biosynthetic process (GO:0042438)5.27333943
36peristalsis (GO:0030432)5.11199218
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.08047148
38sex determination (GO:0007530)5.07265049
39behavioral response to nicotine (GO:0035095)5.05873735
40cellular response to virus (GO:0098586)5.04458702
41ganglion development (GO:0061548)4.99370524
42nucleotide-sugar biosynthetic process (GO:0009226)4.91351472
43intraciliary transport (GO:0042073)4.84261073
44calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.81764264
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.80929590
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.78143839
47DNA replication checkpoint (GO:0000076)4.77987416
48regulation of heart rate by cardiac conduction (GO:0086091)4.75621939
49melanin metabolic process (GO:0006582)4.71253206
50cellular response to glucagon stimulus (GO:0071377)4.67111653
51microtubule bundle formation (GO:0001578)4.64157967
52modulation by symbiont of host cellular process (GO:0044068)4.63640456
53regulation of microtubule-based movement (GO:0060632)4.55427007
54G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.55222243
55microtubule severing (GO:0051013)4.50683985
56snRNA transcription (GO:0009301)4.46115991
57regulation of cytokine production involved in inflammatory response (GO:1900015)4.44454637
58mitotic cell cycle arrest (GO:0071850)4.43665768
59gonadal mesoderm development (GO:0007506)4.41776910
60regulation of cell aging (GO:0090342)4.39055800
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38547787
62nucleoside transport (GO:0015858)4.30794061
63mating behavior (GO:0007617)4.28652670
64secondary metabolite biosynthetic process (GO:0044550)4.28384514
65histone phosphorylation (GO:0016572)4.23401452
66cilium morphogenesis (GO:0060271)4.22658664
67regulation of synapse structural plasticity (GO:0051823)4.22464829
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.21497626
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.21497626
70cellular response to prostaglandin stimulus (GO:0071379)4.14818687
71ADP metabolic process (GO:0046031)4.14614382
72adipose tissue development (GO:0060612)4.13884921
73regulation of nuclear cell cycle DNA replication (GO:0033262)4.13382154
74detection of light stimulus involved in visual perception (GO:0050908)4.12565942
75detection of light stimulus involved in sensory perception (GO:0050962)4.12565942
76natural killer cell mediated cytotoxicity (GO:0042267)4.12557019
77natural killer cell mediated immunity (GO:0002228)4.12557019
78positive regulation of heat generation (GO:0031652)4.11986816
79axoneme assembly (GO:0035082)4.09860396
80negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.05980058
81neuromuscular synaptic transmission (GO:0007274)4.04096356
82negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.96800431
83facial nerve structural organization (GO:0021612)3.95757784
84transepithelial transport (GO:0070633)3.95367946
85sensory perception of taste (GO:0050909)3.94446919
86sialylation (GO:0097503)3.94433645
87neuronal action potential (GO:0019228)3.90867782
88negative regulation of transcription regulatory region DNA binding (GO:2000678)3.90183117
89tRNA modification (GO:0006400)3.86737038
90dopamine receptor signaling pathway (GO:0007212)3.82897930
91cardiac conduction (GO:0061337)3.82737967
92purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.80192683
93ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.80192683
94nucleoside bisphosphate biosynthetic process (GO:0033866)3.80192683
95grooming behavior (GO:0007625)3.78186705
96phosphatidylglycerol biosynthetic process (GO:0006655)3.77113195
97negative regulation of execution phase of apoptosis (GO:1900118)3.75441845
98regulation of phospholipid biosynthetic process (GO:0071071)3.75083549
99estrogen biosynthetic process (GO:0006703)3.72417332
100behavioral response to cocaine (GO:0048148)3.71644752
101olfactory bulb development (GO:0021772)3.69234614
102neuron cell-cell adhesion (GO:0007158)3.64590180
103positive regulation of catecholamine secretion (GO:0033605)3.63930614
104response to glucagon (GO:0033762)3.63104230
105negative regulation of axon extension involved in axon guidance (GO:0048843)3.60553976
106auditory receptor cell differentiation (GO:0042491)3.59117334
107ER overload response (GO:0006983)3.56190452
108cilium movement (GO:0003341)3.55906644
109sphingomyelin metabolic process (GO:0006684)3.55379562
110sequestering of actin monomers (GO:0042989)3.54138967
111regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.52732927
112dosage compensation (GO:0007549)3.52526844
113axon extension involved in axon guidance (GO:0048846)3.51285565
114neuron projection extension involved in neuron projection guidance (GO:1902284)3.51285565
115cellular copper ion homeostasis (GO:0006878)3.50106336
116folic acid metabolic process (GO:0046655)3.46205857
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.41698790
118axonal fasciculation (GO:0007413)3.39068299
119mannose metabolic process (GO:0006013)3.38813840
120sphingosine metabolic process (GO:0006670)3.37787402
121regulation of hydrogen peroxide metabolic process (GO:0010310)3.36835344
122epithelial cilium movement (GO:0003351)3.33691849
123activation of adenylate cyclase activity (GO:0007190)3.33147645
124negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.31783457
125nucleotide transport (GO:0006862)3.30178256
126regulation of protein targeting to membrane (GO:0090313)3.27956396
127sulfur amino acid catabolic process (GO:0000098)3.26687782
128G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25125978
129cardiolipin metabolic process (GO:0032048)3.24019176
130response to auditory stimulus (GO:0010996)3.22908703
131brain morphogenesis (GO:0048854)3.19242211
132one-carbon compound transport (GO:0019755)3.18758673
133neurofilament cytoskeleton organization (GO:0060052)3.18705620
134cellular anion homeostasis (GO:0030002)3.18539056
135acrosome reaction (GO:0007340)3.18032063
136trivalent inorganic anion homeostasis (GO:0072506)3.17062068
137phosphate ion homeostasis (GO:0055062)3.17062068
138cilium or flagellum-dependent cell motility (GO:0001539)3.16185026
139diol metabolic process (GO:0034311)3.14064682
140peptidyl-glutamic acid modification (GO:0018200)3.12865069
141cornea development in camera-type eye (GO:0061303)3.12051803
142cranial nerve structural organization (GO:0021604)3.11196332
143auditory behavior (GO:0031223)3.10482182
144regulation of sodium ion transmembrane transporter activity (GO:2000649)3.09975469
145negative regulation of catenin import into nucleus (GO:0035414)3.08879305
146negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.07608277
147spinal cord development (GO:0021510)3.07598104
148regulation of execution phase of apoptosis (GO:1900117)3.05747336
149regulation of protein kinase C signaling (GO:0090036)3.05289318
150release of cytochrome c from mitochondria (GO:0001836)3.05232032
151regulation of heat generation (GO:0031650)3.04594006
152dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.04192603
153iron coordination entity transport (GO:1901678)3.03404756
154reciprocal DNA recombination (GO:0035825)3.03373294
155reciprocal meiotic recombination (GO:0007131)3.03373294
156ectoderm development (GO:0007398)3.02685580
157behavioral response to pain (GO:0048266)3.01373780
158regulation of protein kinase A signaling (GO:0010738)3.00487562
159keratan sulfate biosynthetic process (GO:0018146)3.00354501
160negative regulation of microtubule polymerization (GO:0031115)2.98419531
161negative regulation of interleukin-8 production (GO:0032717)2.98056160
162phosphate ion transmembrane transport (GO:0035435)2.97287428
163cardiac muscle cell action potential involved in contraction (GO:0086002)2.95715041
164positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.92685531
165negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92269343
166urogenital system development (GO:0001655)2.91397663
167positive regulation of adenylate cyclase activity (GO:0045762)2.90869035
168synaptic transmission, cholinergic (GO:0007271)2.90538203
169signal transduction in absence of ligand (GO:0038034)2.89327362
170extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.89327362
171muscle fiber development (GO:0048747)2.88241431
172axon extension (GO:0048675)2.87825400
173phosphatidylethanolamine biosynthetic process (GO:0006646)2.87271848
174photoreceptor cell maintenance (GO:0045494)2.87070792
175phosphorylated carbohydrate dephosphorylation (GO:0046838)2.85897385
176inositol phosphate dephosphorylation (GO:0046855)2.85897385
177calcium-mediated signaling using intracellular calcium source (GO:0035584)2.85514254
178protein import into peroxisome matrix (GO:0016558)2.85500531
179regulation of female gonad development (GO:2000194)2.85405545
180ovulation cycle (GO:0042698)2.84828163
181G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84525180
182potassium ion transmembrane transport (GO:0071805)2.83781110
183cellular potassium ion transport (GO:0071804)2.83781110
184granulocyte differentiation (GO:0030851)2.82814790
185protein-DNA complex disassembly (GO:0032986)2.82456329
186nucleosome disassembly (GO:0006337)2.82456329
187regulation of cardiac muscle cell apoptotic process (GO:0010665)2.82322574
188membrane depolarization during action potential (GO:0086010)2.81558893
189heme transport (GO:0015886)2.81387658
190cilium assembly (GO:0042384)2.81380974
191keratinocyte development (GO:0003334)2.76902147
192keratan sulfate metabolic process (GO:0042339)2.75303179
193glutathione biosynthetic process (GO:0006750)2.75281692
194sensory perception of smell (GO:0007608)15.3952293
195cellular response to ATP (GO:0071318)11.0804890
196regulation of chromatin binding (GO:0035561)10.0900452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.35334459
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.51420190
3VDR_21846776_ChIP-Seq_THP-1_Human4.47024287
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.74802986
5TAF15_26573619_Chip-Seq_HEK293_Human3.61371194
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.41723883
7ZNF263_19887448_ChIP-Seq_K562_Human3.28942964
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.24537107
9P68_20966046_ChIP-Seq_HELA_Human3.19909185
10LXR_22292898_ChIP-Seq_THP-1_Human3.10552173
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05538171
12ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.01374842
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.79306079
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.75810420
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.73746613
16XRN2_22483619_ChIP-Seq_HELA_Human2.66941199
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57372008
18BCL6_27268052_Chip-Seq_Bcells_Human2.46511444
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.46387996
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45544250
21* MAF_26560356_Chip-Seq_TH2_Human2.43067448
22DROSHA_22980978_ChIP-Seq_HELA_Human2.39947182
23* CTCF_27219007_Chip-Seq_Bcells_Human2.37036700
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.25342537
25* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.24136536
26RACK7_27058665_Chip-Seq_MCF-7_Human2.21578604
27VDR_24763502_ChIP-Seq_THP-1_Human2.11814428
28TET1_21451524_ChIP-Seq_MESCs_Mouse2.11606040
29AHR_22903824_ChIP-Seq_MCF-7_Human2.10698807
30CTCF_27219007_Chip-Seq_ERYTHROID_Human2.03467408
31SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.00361925
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98635641
33* RARB_24833708_ChIP-Seq_LIVER_Mouse1.97605663
34SMC4_20622854_ChIP-Seq_HELA_Human1.93306291
35GBX2_23144817_ChIP-Seq_PC3_Human1.92772477
36* MAF_26560356_Chip-Seq_TH1_Human1.87144591
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.86739848
38FOXP1_21924763_ChIP-Seq_HESCs_Human1.84954047
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84010137
40* RARA_24833708_ChIP-Seq_LIVER_Mouse1.83359868
41* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.82705928
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80937880
43KDM2B_26808549_Chip-Seq_K562_Human1.78767228
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.77355137
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76342117
46CTCF_21964334_Chip-Seq_Bcells_Human1.74591092
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.74436771
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73172873
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.73007227
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.72765972
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72343036
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72180877
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69796095
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69198782
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69198782
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64564031
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62796306
58SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62526816
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61700731
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58214917
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57934374
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57065430
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.55987059
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55171549
65MYC_22102868_ChIP-Seq_BL_Human1.54462715
66KDM2B_26808549_Chip-Seq_DND41_Human1.54159097
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50710690
68CREB1_26743006_Chip-Seq_LNCaP_Human1.50248466
69CTCF_21964334_ChIP-Seq_BJAB-B_Human1.50108023
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.50082314
71OCT4_20526341_ChIP-Seq_ESCs_Human1.48748455
72RUNX1_26923725_Chip-Seq_HPCs_Mouse1.45691484
73ETS1_21867929_ChIP-Seq_TH2_Mouse1.42536578
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41621976
75TP53_22127205_ChIP-Seq_IMR90_Human1.41214145
76SA1_27219007_Chip-Seq_Bcells_Human1.40078399
77UTX_26944678_Chip-Seq_JUKART_Human1.39946757
78REST_21632747_ChIP-Seq_MESCs_Mouse1.39245599
79* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.39140280
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38347742
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36327530
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.35372181
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35260679
84* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33896353
85DCP1A_22483619_ChIP-Seq_HELA_Human1.33536183
86CTCF_20526341_ChIP-Seq_ESCs_Human1.32486184
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31728681
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31563674
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31365584
90TCF7_22412390_ChIP-Seq_EML_Mouse1.30794415
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.28812461
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28592741
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28353856
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28353662
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27298960
96VDR_22108803_ChIP-Seq_LS180_Human1.26891832
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26037399
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.25578469
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24212978
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.23951977
101* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23813630
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23784612
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23539218
104STAT3_18555785_ChIP-Seq_MESCs_Mouse1.23390176
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23241856
106ATF3_27146783_Chip-Seq_COLON_Human1.22639979
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.21423832
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21379862
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.21127824
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20873837
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20870675
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19918112
113P300_27268052_Chip-Seq_Bcells_Human1.19636713
114E2F1_20622854_ChIP-Seq_HELA_Human1.19618524
115P53_21459846_ChIP-Seq_SAOS-2_Human1.19543858
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18808579
117NCOR1_26117541_ChIP-Seq_K562_Human1.17906926
118TP63_22573176_ChIP-Seq_HFKS_Human1.17427807
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17355691
120* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.15688811
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.14100819
122CTCF_26484167_Chip-Seq_Bcells_Mouse1.13333007
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.13307973
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12346016
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11380177
126RNF2_27304074_Chip-Seq_NSC_Mouse1.10503382
127SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08588324
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08423079
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08417244
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.08185665
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.07918761
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07549594
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07523354
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.06862917
135NANOG_20526341_ChIP-Seq_ESCs_Human1.06632626
136ESR2_21235772_ChIP-Seq_MCF-7_Human1.05841594
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05344488
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.05267856
139MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05199070
140* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05140483
141GABP_19822575_ChIP-Seq_HepG2_Human1.04730866
142TET1_21490601_ChIP-Seq_MESCs_Mouse1.03465552
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03180682
144OCT4_19829295_ChIP-Seq_ESCs_Human1.03143257
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01696335
146EZH2_27304074_Chip-Seq_ESCs_Mouse1.00047675
147BCOR_27268052_Chip-Seq_Bcells_Human0.99579767
148* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99421729
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.99221583
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99118570
151RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98838641
152* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98482054
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.98179516
154KLF4_19829295_ChIP-Seq_ESCs_Human0.97416783
155SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97413212
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97297897
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96529014
158CDX2_22108803_ChIP-Seq_LS180_Human0.95934237
159SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95676447
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95432911
161* RUNX2_22187159_ChIP-Seq_PCA_Human0.94948322
162STAT1_20625510_ChIP-Seq_HELA_Human0.93044605
163LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92551541
164* ERA_21632823_ChIP-Seq_H3396_Human0.91934271
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91399781
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91056893
167GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90989777
168SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90962239
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90936254
170PHF8_20622854_ChIP-Seq_HELA_Human0.90409394
171FOXH1_21741376_ChIP-Seq_EPCs_Human0.90019414
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89947458
173SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89826812
174TP53_18474530_ChIP-ChIP_U2OS_Human0.89540954
175WDR5_24793694_ChIP-Seq_LNCAP_Human0.89280003
176SMAD4_21799915_ChIP-Seq_A2780_Human0.88884908
177SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88635193
178CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88434593
179SMAD4_21741376_ChIP-Seq_HESCs_Human0.85885942
180RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85511660
181RARB_27405468_Chip-Seq_BRAIN_Mouse0.85266621
182POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82988741
183TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82988741
184EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82505246
185JUN_21703547_ChIP-Seq_K562_Human0.81756071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity7.13678263
2MP0003136_yellow_coat_color7.01355509
3MP0008789_abnormal_olfactory_epithelium6.59742988
4MP0005423_abnormal_somatic_nervous6.21921689
5MP0005394_taste/olfaction_phenotype5.94001795
6MP0005499_abnormal_olfactory_system5.94001795
7MP0005645_abnormal_hypothalamus_physiol4.42984474
8MP0005377_hearing/vestibular/ear_phenot3.47842061
9MP0003878_abnormal_ear_physiology3.47842061
10MP0003806_abnormal_nucleotide_metabolis3.26587077
11MP0002160_abnormal_reproductive_system3.22554855
12MP0001968_abnormal_touch/_nociception3.14807493
13MP0005083_abnormal_biliary_tract2.67647950
14MP0004381_abnormal_hair_follicle2.65316629
15MP0001485_abnormal_pinna_reflex2.34816370
16MP0002638_abnormal_pupillary_reflex2.32303465
17MP0001756_abnormal_urination2.25138586
18MP0002736_abnormal_nociception_after2.24220727
19MP0000751_myopathy2.23666512
20MP0002184_abnormal_innervation2.23014440
21MP0002822_catalepsy2.03370797
22MP0004270_analgesia2.00092519
23MP0001984_abnormal_olfaction10.9968747
24MP0002102_abnormal_ear_morphology1.98245048
25MP0000372_irregular_coat_pigmentation1.83667970
26MP0004858_abnormal_nervous_system1.81212445
27MP0005389_reproductive_system_phenotype1.76682122
28MP0001542_abnormal_bone_strength1.74270810
29MP0000013_abnormal_adipose_tissue1.73082017
30MP0000538_abnormal_urinary_bladder1.68347688
31MP0006276_abnormal_autonomic_nervous1.67376551
32MP0000003_abnormal_adipose_tissue1.63237642
33MP0002233_abnormal_nose_morphology1.62501278
34MP0003453_abnormal_keratinocyte_physiol1.60858816
35MP0003111_abnormal_nucleus_morphology1.54468069
36MP0000750_abnormal_muscle_regeneration1.44902371
37MP0001661_extended_life_span1.42482760
38MP0002735_abnormal_chemical_nociception1.40844206
39MP0001188_hyperpigmentation1.39175766
40MP0005646_abnormal_pituitary_gland1.36110881
41MP0004043_abnormal_pH_regulation1.31341252
42MP0004130_abnormal_muscle_cell1.30971011
43MP0002557_abnormal_social/conspecific_i1.27994907
44MP0001293_anophthalmia1.24874727
45MP0003787_abnormal_imprinting1.22328034
46MP0005332_abnormal_amino_acid1.20867125
47MP0000778_abnormal_nervous_system1.19314330
48MP0002752_abnormal_somatic_nervous1.18972190
49MP0005330_cardiomyopathy1.13516401
50MP0005076_abnormal_cell_differentiation1.10898944
51MP0002882_abnormal_neuron_morphology1.04090706
52MP0005584_abnormal_enzyme/coenzyme_acti1.03532680
53MP0002734_abnormal_mechanical_nocicepti1.02581281
54MP0003705_abnormal_hypodermis_morpholog1.02230237
55MP0005187_abnormal_penis_morphology0.99731579
56MP0002928_abnormal_bile_duct0.99121813
57MP0002653_abnormal_ependyma_morphology0.99099410
58MP0002938_white_spotting0.97988435
59MP0001958_emphysema0.96341042
60MP0002132_abnormal_respiratory_system0.96138338
61MP0002877_abnormal_melanocyte_morpholog0.95749022
62MP0003635_abnormal_synaptic_transmissio0.95463120
63MP0001486_abnormal_startle_reflex0.95339356
64MP0001664_abnormal_digestion0.94610480
65MP0003252_abnormal_bile_duct0.91894115
66MP0004019_abnormal_vitamin_homeostasis0.91824055
67MP0004859_abnormal_synaptic_plasticity0.91661525
68MP0002272_abnormal_nervous_system0.91573082
69MP0005623_abnormal_meninges_morphology0.90379655
70MP0001765_abnormal_ion_homeostasis0.89932781
71MP0005501_abnormal_skin_physiology0.89336220
72MP0004811_abnormal_neuron_physiology0.85847282
73MP0003880_abnormal_central_pattern0.84298816
74MP0005174_abnormal_tail_pigmentation0.81931473
75MP0004957_abnormal_blastocyst_morpholog0.80317239
76MP0002152_abnormal_brain_morphology0.79436282
77MP0002127_abnormal_cardiovascular_syste0.79151208
78MP0000747_muscle_weakness0.78398016
79MP0000026_abnormal_inner_ear0.76608891
80MP0002063_abnormal_learning/memory/cond0.74824861
81MP0003861_abnormal_nervous_system0.73605700
82MP0002909_abnormal_adrenal_gland0.72934680
83MP0009333_abnormal_splenocyte_physiolog0.71050395
84MP0003448_altered_tumor_morphology0.68345493
85MP0000367_abnormal_coat/_hair0.67981397
86MP0001348_abnormal_lacrimal_gland0.67326271
87MP0002075_abnormal_coat/hair_pigmentati0.66927017
88MP0001963_abnormal_hearing_physiology0.66826720
89MP0001970_abnormal_pain_threshold0.66739222
90MP0010771_integument_phenotype0.66405451
91MP0008877_abnormal_DNA_methylation0.64434209
92MP0004133_heterotaxia0.64248611
93MP0000358_abnormal_cell_content/0.63690164
94MP0008874_decreased_physiological_sensi0.63207067
95MP0001905_abnormal_dopamine_level0.62278961
96MP0003693_abnormal_embryo_hatching0.61890079
97MP0004742_abnormal_vestibular_system0.60764835
98MP0009931_abnormal_skin_appearance0.59276730
99MP0003879_abnormal_hair_cell0.58547732
100MP0000470_abnormal_stomach_morphology0.58401259
101MP0002229_neurodegeneration0.57941226
102MP0001529_abnormal_vocalization0.57714737
103MP0010234_abnormal_vibrissa_follicle0.56318666
104MP0005410_abnormal_fertilization0.56263487
105MP0009643_abnormal_urine_homeostasis0.56035574
106MP0001873_stomach_inflammation0.55969803
107MP0002751_abnormal_autonomic_nervous0.55742965
108MP0002572_abnormal_emotion/affect_behav0.55021778
109MP0002019_abnormal_tumor_incidence0.54195332
110MP0005084_abnormal_gallbladder_morpholo0.54088695
111MP0010094_abnormal_chromosome_stability0.53926233
112MP0005058_abnormal_lysosome_morphology0.53568721
113MP0002067_abnormal_sensory_capabilities0.52255522
114MP0005365_abnormal_bile_salt0.51544438
115MP0003077_abnormal_cell_cycle0.50560661
116MP0005171_absent_coat_pigmentation0.50293519
117MP0002933_joint_inflammation0.49166231
118MP0005551_abnormal_eye_electrophysiolog0.48930806
119MP0001944_abnormal_pancreas_morphology0.48134380
120MP0003942_abnormal_urinary_system0.47232092
121MP0005409_darkened_coat_color0.46423782
122MP0002136_abnormal_kidney_physiology0.45710733
123MP0005220_abnormal_exocrine_pancreas0.45514466
124MP0002210_abnormal_sex_determination0.44205590
125MP0000631_abnormal_neuroendocrine_gland0.43562763
126MP0003091_abnormal_cell_migration0.42914375
127MP0001324_abnormal_eye_pigmentation0.42714602
128MP0004215_abnormal_myocardial_fiber0.42597125
129MP0002064_seizures0.42362634
130MP0001501_abnormal_sleep_pattern0.41641696
131MP0001119_abnormal_female_reproductive0.40765251
132MP0005375_adipose_tissue_phenotype0.40526012
133MP0001502_abnormal_circadian_rhythm0.40283298
134MP0001186_pigmentation_phenotype0.40228493
135MP0005195_abnormal_posterior_eye0.40181622
136MP0005257_abnormal_intraocular_pressure0.39966836
137MP0003634_abnormal_glial_cell0.39838982
138MP0003303_peritoneal_inflammation0.39482760
139MP0003632_abnormal_nervous_system0.37726876
140MP0000371_diluted_coat_color0.37703324
141MP0002254_reproductive_system_inflammat0.37698119
142MP0010352_gastrointestinal_tract_polyps0.36896098
143MP0008875_abnormal_xenobiotic_pharmacok0.36760782
144MP0002092_abnormal_eye_morphology0.36688978
145MP0005253_abnormal_eye_physiology0.35654166
146MP0001346_abnormal_lacrimal_gland0.35638870
147MP0002081_perinatal_lethality0.35618940
148MP0003137_abnormal_impulse_conducting0.35379763
149MP0009745_abnormal_behavioral_response0.35081462
150MP0009278_abnormal_bone_marrow0.35005191
151MP0002095_abnormal_skin_pigmentation0.34683467
152MP0004197_abnormal_fetal_growth/weight/0.34325121
153MP0003763_abnormal_thymus_physiology0.33954326
154MP0000613_abnormal_salivary_gland0.32841425
155MP0004782_abnormal_surfactant_physiolog0.32683262
156MP0000015_abnormal_ear_pigmentation0.32399076
157MP0010770_preweaning_lethality0.31442910
158MP0002082_postnatal_lethality0.31442910
159MP0001191_abnormal_skin_condition0.31283265
160MP0002118_abnormal_lipid_homeostasis0.31178022
161MP0008770_decreased_survivor_rate0.31038350
162MP0002066_abnormal_motor_capabilities/c0.30606179
163MP0002069_abnormal_eating/drinking_beha0.29753205
164MP0009703_decreased_birth_body0.29438542
165MP0010386_abnormal_urinary_bladder0.28837304
166MP0003011_delayed_dark_adaptation0.28079468
167MP0001919_abnormal_reproductive_system0.26981649
168MP0004185_abnormal_adipocyte_glucose0.26419953
169MP0009384_cardiac_valve_regurgitation0.26280461
170MP0000678_abnormal_parathyroid_gland0.25595015
171MP0001216_abnormal_epidermal_layer0.24869962
172MP0002177_abnormal_outer_ear0.24706972

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)7.04541677
2Testicular atrophy (HP:0000029)6.28338184
3Retinal dysplasia (HP:0007973)5.91391475
4Rectal fistula (HP:0100590)5.84417926
5Rectovaginal fistula (HP:0000143)5.84417926
6Poikiloderma (HP:0001029)5.61488683
7Intestinal fistula (HP:0100819)5.48926159
8Vaginal fistula (HP:0004320)5.37718250
9Palpitations (HP:0001962)5.32740644
10Thin bony cortex (HP:0002753)5.29257567
11Annular pancreas (HP:0001734)5.11433875
12Attenuation of retinal blood vessels (HP:0007843)5.07673493
13Hypothermia (HP:0002045)5.02482694
14Anosmia (HP:0000458)4.97457544
15Facial hemangioma (HP:0000329)4.93792606
16Ulnar bowing (HP:0003031)4.93151215
17Congenital stationary night blindness (HP:0007642)4.90440773
18Abnormal respiratory motile cilium physiology (HP:0012261)4.84339277
19Abnormal ciliary motility (HP:0012262)4.81364020
20Popliteal pterygium (HP:0009756)4.71118921
21Turricephaly (HP:0000262)4.66902959
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.55270034
23Molar tooth sign on MRI (HP:0002419)4.54657903
24Abnormality of midbrain morphology (HP:0002418)4.54657903
25Atonic seizures (HP:0010819)4.54284854
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.44351669
27Coronal craniosynostosis (HP:0004440)4.43474079
28Dyschromatopsia (HP:0007641)4.42866343
29Pancreatic fibrosis (HP:0100732)4.40676900
30Akinesia (HP:0002304)4.25574884
31Abnormality of the intrinsic pathway (HP:0010989)4.17399901
32Bifid tongue (HP:0010297)4.12789894
33Facial diplegia (HP:0001349)4.06261977
34Febrile seizures (HP:0002373)4.05134934
35Abnormal respiratory motile cilium morphology (HP:0005938)3.98096582
36Abnormal respiratory epithelium morphology (HP:0012253)3.98096582
37Aplasia of the musculature (HP:0100854)3.94978345
38Chorioretinal atrophy (HP:0000533)3.91418975
39Supernumerary spleens (HP:0009799)3.88128293
40Fetal akinesia sequence (HP:0001989)3.87824079
41Squamous cell carcinoma (HP:0002860)3.79884500
42Gait imbalance (HP:0002141)3.78664895
43Limb dystonia (HP:0002451)3.73562170
44Congenital primary aphakia (HP:0007707)3.72031980
45Anteriorly placed anus (HP:0001545)3.72019539
46Short chin (HP:0000331)3.71480574
47Medial flaring of the eyebrow (HP:0010747)3.66419966
48Insomnia (HP:0100785)3.52710454
49Delayed epiphyseal ossification (HP:0002663)3.51766928
50Nephrogenic diabetes insipidus (HP:0009806)3.47532896
51Patellar aplasia (HP:0006443)3.45716902
52Abolished electroretinogram (ERG) (HP:0000550)3.42932714
53Amniotic constriction ring (HP:0009775)3.34038343
54Abnormality of placental membranes (HP:0011409)3.34038343
55Hyperglycinemia (HP:0002154)3.31200536
56Abnormality of the costochondral junction (HP:0000919)3.29130257
57Postaxial hand polydactyly (HP:0001162)3.23062975
58Prolonged partial thromboplastin time (HP:0003645)3.20282998
59Aplasia/Hypoplasia of the patella (HP:0006498)3.19515989
60Birth length less than 3rd percentile (HP:0003561)3.19336713
61True hermaphroditism (HP:0010459)3.13796653
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08271196
63Joint hemorrhage (HP:0005261)3.08191302
64Cystic liver disease (HP:0006706)3.07139595
65Abnormal albumin level (HP:0012116)3.07075830
66Hypoalbuminemia (HP:0003073)3.07075830
67Male infertility (HP:0003251)3.05953013
68Joint stiffness (HP:0001387)3.03305033
69Occipital encephalocele (HP:0002085)3.00394443
70Hemorrhage of the eye (HP:0011885)2.97493997
71Capillary hemangiomas (HP:0005306)2.95960617
72Poor coordination (HP:0002370)2.95113235
73Enlarged epiphyses (HP:0010580)2.92876175
74Xerostomia (HP:0000217)2.90139168
75Abnormality of macular pigmentation (HP:0008002)2.89618807
76Absent thumb (HP:0009777)2.88830232
77Rhinitis (HP:0012384)2.88337648
78Atrioventricular block (HP:0001678)2.86306114
79Genital tract atresia (HP:0001827)2.83261745
80Premature graying of hair (HP:0002216)2.82784614
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.82266935
82Hypophosphatemic rickets (HP:0004912)2.80687621
83Absent/shortened dynein arms (HP:0200106)2.79301886
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.79301886
85Mesangial abnormality (HP:0001966)2.78667296
86Primary atrial arrhythmia (HP:0001692)2.76464476
87Choanal stenosis (HP:0000452)2.73676372
88Renovascular hypertension (HP:0100817)2.73420477
89Pendular nystagmus (HP:0012043)2.72240416
90Myotonia (HP:0002486)2.69966456
91Abnormal EKG (HP:0003115)2.67013930
92Vaginal atresia (HP:0000148)2.66507257
93Pancreatic cysts (HP:0001737)2.66199132
94Hypochromic microcytic anemia (HP:0004840)2.65111246
95Chronic sinusitis (HP:0011109)2.64215312
96Syncope (HP:0001279)2.64193551
97Widely patent fontanelles and sutures (HP:0004492)2.63461928
98Supraventricular tachycardia (HP:0004755)2.61160702
99Bowed forearm bones (HP:0003956)2.60467144
100Bowing of the arm (HP:0006488)2.60467144
101Nephronophthisis (HP:0000090)2.59814641
102Torticollis (HP:0000473)2.55755430
103Aplasia/Hypoplasia of the lens (HP:0008063)2.54000568
104Abnormal biliary tract physiology (HP:0012439)2.53733299
105Bile duct proliferation (HP:0001408)2.53733299
106Short humerus (HP:0005792)2.53579936
107Choroideremia (HP:0001139)2.52775594
108Supraventricular arrhythmia (HP:0005115)2.51693674
109Oculomotor apraxia (HP:0000657)2.51444587
110Abnormality of the diencephalon (HP:0010662)2.50516498
111Flat occiput (HP:0005469)2.49680628
112Bony spicule pigmentary retinopathy (HP:0007737)2.49266215
113Narrow nasal bridge (HP:0000446)2.48099694
114Increased number of teeth (HP:0011069)2.47336954
115Decreased central vision (HP:0007663)2.45415844
116Autoamputation (HP:0001218)2.40378512
117Complete atrioventricular canal defect (HP:0001674)2.38136443
118Basal cell carcinoma (HP:0002671)2.37556621
119Postaxial foot polydactyly (HP:0001830)2.37393016
120Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36432349
121Neonatal respiratory distress (HP:0002643)2.35044285
122Abnormality of the hepatic vasculature (HP:0006707)2.34731522
123Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33940672
124Reduced antithrombin III activity (HP:0001976)2.33587091
125Polydipsia (HP:0001959)2.31854338
126Abnormal drinking behavior (HP:0030082)2.31854338
127Elfin facies (HP:0004428)2.28839045
128Aplasia/hypoplasia of the humerus (HP:0006507)2.28498052
129Bradycardia (HP:0001662)2.28440559
130Dysphonia (HP:0001618)2.28204924
131Sclerocornea (HP:0000647)2.27273888
132Chronic bronchitis (HP:0004469)2.25721804
133Renal Fanconi syndrome (HP:0001994)2.25417871
134Abnormality of dentin (HP:0010299)2.23308036
135Abnormal cortical bone morphology (HP:0003103)2.23033512
136Absent radius (HP:0003974)2.22501080
137Breast hypoplasia (HP:0003187)2.21400558
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18079488
139Bronchiectasis (HP:0002110)2.17045743
140Thin ribs (HP:0000883)2.16689731
141Pterygium (HP:0001059)2.15684683
142Absence seizures (HP:0002121)2.13156500
143Hyperacusis (HP:0010780)2.13042728
144Hypoplasia of the pons (HP:0012110)2.12925471
145Decreased circulating renin level (HP:0003351)2.12434926
146Malignant hyperthermia (HP:0002047)2.12352980
147Chronic hepatic failure (HP:0100626)2.11777998
148Wormian bones (HP:0002645)2.10270418
149Myopathic facies (HP:0002058)2.09533244
150Absent forearm bone (HP:0003953)2.08557605
151Aplasia involving forearm bones (HP:0009822)2.08557605
152Neonatal onset (HP:0003623)2.08198416
153Cone-rod dystrophy (HP:0000548)2.07617607
154Humeroradial synostosis (HP:0003041)2.06829668
155Synostosis involving the elbow (HP:0003938)2.06829668
156Zonular cataract (HP:0010920)2.05061440
157Male pseudohermaphroditism (HP:0000037)2.04270675
158Diminished movement (HP:0002374)2.02759161
159Tubular atrophy (HP:0000092)2.02153389
160Abnormal epiphyseal ossification (HP:0010656)2.01484214
161Hyperinsulinemic hypoglycemia (HP:0000825)2.00892496
162Focal seizures (HP:0007359)2.00279187
163Overriding aorta (HP:0002623)2.00065374
164Abnormality of the renal medulla (HP:0100957)1.98532687
165Prolonged QT interval (HP:0001657)1.98477648
166Increased hepatocellular lipid droplets (HP:0006565)1.97189384
167Atrioventricular canal defect (HP:0006695)1.97163120
168Abnormal sex determination (HP:0012244)1.96028066
169Sex reversal (HP:0012245)1.96028066
170Type 2 muscle fiber atrophy (HP:0003554)1.95873464
171Craniofacial dystonia (HP:0012179)1.95324878
172Tubulointerstitial nephritis (HP:0001970)1.94930717
173Lipid accumulation in hepatocytes (HP:0006561)1.94221984
174Short thumb (HP:0009778)1.93717639
175Abnormality of the pons (HP:0007361)1.92955785
176Congenital hepatic fibrosis (HP:0002612)1.92871087
177Left ventricular hypertrophy (HP:0001712)1.91278098
178Microglossia (HP:0000171)1.91268670
179Cystic hygroma (HP:0000476)1.89025980
180Cheilitis (HP:0100825)1.88695361
181Preaxial hand polydactyly (HP:0001177)1.87859993
182Abnormality of pain sensation (HP:0010832)1.86683771
183Impaired pain sensation (HP:0007328)1.86683771
184Decreased testicular size (HP:0008734)1.84697785
185Facial cleft (HP:0002006)1.84529551
186Curly hair (HP:0002212)1.83261420
187Erectile abnormalities (HP:0100639)1.82554025
188Pelvic girdle muscle weakness (HP:0003749)1.82243368
189Bell-shaped thorax (HP:0001591)1.82029281
190Polycystic ovaries (HP:0000147)1.81905158
191Muscle fiber atrophy (HP:0100295)1.79075154
192Median cleft lip (HP:0000161)1.78840685
193Hypoplasia of the radius (HP:0002984)1.78198672
194Abnormality of the neuromuscular junction (HP:0003398)1.78186433
195Fatigable weakness (HP:0003473)1.78186433
196Intellectual disability, moderate (HP:0002342)1.77673865
197Renal hypoplasia (HP:0000089)1.76909321
198Atelectasis (HP:0100750)1.76879264
199Focal dystonia (HP:0004373)1.76558775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF7.00804790
2RIPK15.46870567
3MAPK154.67489770
4ERBB33.97515926
5PIM23.94268710
6BLK3.47607904
7TLK13.40640962
8MUSK3.19087684
9BRAF2.94825249
10BMPR22.86607786
11TESK22.70639204
12GRK62.70228503
13ZAK2.60934966
14STK162.41770230
15SIK22.38977113
16MST1R2.37447691
17ACVR1B2.30341347
18PRPF4B2.14327565
19STK242.02004806
20DAPK21.94373799
21PDK21.74329392
22ICK1.64437562
23EEF2K1.63840722
24NTRK21.63692403
25SIK11.61777318
26WNK11.60661902
27ILK1.57348313
28ADRBK11.52349722
29CAMK2B1.50046147
30AKT31.47211297
31CSNK1A1L1.44380021
32MAP2K71.36555593
33CAMKK21.35290095
34PLK41.34941231
35ADRBK21.33092248
36ERN11.31996760
37CAMK2G1.30369641
38MAP3K111.28982396
39CAMK1D1.28542911
40ZAP701.26156053
41MAPK131.24533088
42TRIB31.24229849
43CAMK2D1.23321605
44RAF11.23294049
45PDPK11.21860628
46DYRK1B1.18457263
47PHKG21.17276009
48PHKG11.17276009
49IRAK21.16570061
50OXSR11.13650061
51NEK21.09478794
52RPS6KA21.08621689
53CDK41.06742313
54CDK151.06258075
55PLK21.05195629
56MAP2K41.03531956
57HIPK21.03070512
58CDK180.99829383
59CAMK1G0.99170561
60CDK11A0.97831303
61CSNK1G30.97284097
62MINK10.97151524
63PLK30.96381720
64CSNK1G20.95687643
65CCNB10.93378188
66MARK10.92512732
67CSNK1G10.84252314
68BCKDK0.83196028
69MET0.81755319
70DDR20.80317234
71MAPKAPK30.80156583
72MAP4K10.74619778
73STK110.74548300
74MAPK120.72913985
75BMX0.72655595
76TBK10.70311458
77MAP3K120.69661175
78CDK60.68526983
79CDK140.68514900
80MELK0.68015392
81STK390.67401925
82SGK4940.66876220
83SGK2230.66876220
84TGFBR10.65191571
85BMPR1B0.64013482
86EPHA20.63676273
87CSNK1D0.61527660
88DYRK30.59534711
89PRKCE0.59371737
90PRKCZ0.58407757
91CASK0.55376144
92IRAK10.54225033
93ATR0.50368371
94PRKD10.49784867
95PRKCG0.48543182
96SGK20.48379745
97CHEK20.48225102
98GRK50.47870163
99MARK20.47390613
100UHMK10.46323413
101SIK30.45639089
102MAPKAPK20.45474305
103DAPK10.43929076
104CAMKK10.42382139
105PRKCI0.41706354
106PRKD20.41694104
107CDK30.41016260
108MAPK90.39208811
109DAPK30.39198477
110PBK0.39080326
111MAP3K100.38180093
112GRK10.37440527
113CAMK40.36210434
114MAP3K60.35347034
115PKN20.34638759
116TYRO30.34135913
117MAP3K40.33207046
118PRKD30.33061355
119RPS6KL10.32815638
120RPS6KC10.32815638
121MAPK110.32683482
122PAK10.32599972
123AKT20.32436143
124PRKAA10.32279621
125DYRK20.31759379
126IKBKB0.31252166
127IKBKE0.30532184
128NEK60.28397923
129MAP2K30.27968862
130CDK50.26503731
131TRIM280.26169539
132PDGFRA0.25842287
133MAPK80.25217515
134PLK10.25028753
135CAMK2A0.24520038
136PAK40.24502687
137RPS6KA60.23848736
138MAP2K60.22446049
139TRPM70.21323118
140MAP3K70.19788392
141CSK0.19758671
142MAP2K10.19211659
143SMG10.17790213
144SGK30.17719716
145CDK10.16767525
146RPS6KA10.16434413
147RPS6KA50.16400628
148WNK40.15606107
149PRKCQ0.15460906
150STK380.15170911
151AURKA0.15165612
152MAPKAPK50.14550597
153PRKCH0.14252236
154LMTK20.13583880
155RPS6KB10.13581128
156MTOR0.13475557
157PRKACA0.13306013
158ROCK10.13026149
159MAPK30.10514628

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006048.30630844
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.15016062
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.37335095
4Fructose and mannose metabolism_Homo sapiens_hsa000513.21231686
5Phototransduction_Homo sapiens_hsa047443.06911405
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.75146372
7Morphine addiction_Homo sapiens_hsa050322.46374641
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.35860561
9Circadian entrainment_Homo sapiens_hsa047132.14284246
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12229657
11Dopaminergic synapse_Homo sapiens_hsa047282.08538143
12GABAergic synapse_Homo sapiens_hsa047272.01041333
13Olfactory transduction_Homo sapiens_hsa0474010.8353097
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.99911476
15Serotonergic synapse_Homo sapiens_hsa047261.98379323
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97336931
17Taste transduction_Homo sapiens_hsa047421.96892146
18Cholinergic synapse_Homo sapiens_hsa047251.89762087
19Fanconi anemia pathway_Homo sapiens_hsa034601.88533353
20Glutamatergic synapse_Homo sapiens_hsa047241.85658451
21Circadian rhythm_Homo sapiens_hsa047101.79964234
22Insulin secretion_Homo sapiens_hsa049111.67112914
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61745975
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59896522
25Synaptic vesicle cycle_Homo sapiens_hsa047211.59651599
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51712924
27Hedgehog signaling pathway_Homo sapiens_hsa043401.49919078
28Vitamin digestion and absorption_Homo sapiens_hsa049771.46393580
29Sulfur relay system_Homo sapiens_hsa041221.42673527
30Pyruvate metabolism_Homo sapiens_hsa006201.35717656
31Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29337862
32Alcoholism_Homo sapiens_hsa050341.27533670
33Collecting duct acid secretion_Homo sapiens_hsa049661.26059599
34Endometrial cancer_Homo sapiens_hsa052131.25065281
35Histidine metabolism_Homo sapiens_hsa003401.20397909
36Fatty acid biosynthesis_Homo sapiens_hsa000611.12141106
37beta-Alanine metabolism_Homo sapiens_hsa004101.10415801
38cAMP signaling pathway_Homo sapiens_hsa040241.10101727
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05581903
40Hepatitis C_Homo sapiens_hsa051600.98212012
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98064105
42Colorectal cancer_Homo sapiens_hsa052100.96800510
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95540701
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94570442
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94380483
46Tight junction_Homo sapiens_hsa045300.89213817
47RNA polymerase_Homo sapiens_hsa030200.88067589
48Prion diseases_Homo sapiens_hsa050200.86511314
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86156404
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85830763
51Ras signaling pathway_Homo sapiens_hsa040140.83767425
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82400313
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80178834
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78072062
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75962161
56Lysine degradation_Homo sapiens_hsa003100.75548579
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.75478725
58Lysosome_Homo sapiens_hsa041420.72111968
59Chemokine signaling pathway_Homo sapiens_hsa040620.72021592
60Hippo signaling pathway_Homo sapiens_hsa043900.71988930
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67610730
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.66194235
63Amphetamine addiction_Homo sapiens_hsa050310.65507084
64Homologous recombination_Homo sapiens_hsa034400.65495859
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62257828
66Inositol phosphate metabolism_Homo sapiens_hsa005620.61128774
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61083533
68Propanoate metabolism_Homo sapiens_hsa006400.60868358
69GnRH signaling pathway_Homo sapiens_hsa049120.59664634
70Melanogenesis_Homo sapiens_hsa049160.58490733
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58458980
72Ovarian steroidogenesis_Homo sapiens_hsa049130.57503677
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.56674282
74Vibrio cholerae infection_Homo sapiens_hsa051100.56004852
75Estrogen signaling pathway_Homo sapiens_hsa049150.52377331
76Gastric acid secretion_Homo sapiens_hsa049710.52376796
77Gap junction_Homo sapiens_hsa045400.52076417
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50709457
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50536919
80Arginine biosynthesis_Homo sapiens_hsa002200.50390536
81Pancreatic cancer_Homo sapiens_hsa052120.50191781
82Basal cell carcinoma_Homo sapiens_hsa052170.49616680
83Bile secretion_Homo sapiens_hsa049760.49361354
84mTOR signaling pathway_Homo sapiens_hsa041500.49164058
85Base excision repair_Homo sapiens_hsa034100.48841749
86Thyroid hormone synthesis_Homo sapiens_hsa049180.48823937
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.48005642
88Phenylalanine metabolism_Homo sapiens_hsa003600.47654268
89Fat digestion and absorption_Homo sapiens_hsa049750.46542440
90ABC transporters_Homo sapiens_hsa020100.45586110
91Cocaine addiction_Homo sapiens_hsa050300.45273236
92Insulin signaling pathway_Homo sapiens_hsa049100.45089542
93Apoptosis_Homo sapiens_hsa042100.44533663
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.43990349
95Axon guidance_Homo sapiens_hsa043600.43799146
96Fatty acid degradation_Homo sapiens_hsa000710.43370998
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43013532
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41474164
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41266476
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41127282
101Bladder cancer_Homo sapiens_hsa052190.40630209
102Glucagon signaling pathway_Homo sapiens_hsa049220.40419937
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.40255020
104Purine metabolism_Homo sapiens_hsa002300.39910989
105Pyrimidine metabolism_Homo sapiens_hsa002400.38803321
106Salivary secretion_Homo sapiens_hsa049700.38727967
107Chronic myeloid leukemia_Homo sapiens_hsa052200.38565745
108Other glycan degradation_Homo sapiens_hsa005110.38254250
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38010008
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37236200
111Nicotine addiction_Homo sapiens_hsa050330.36137857
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35732246
113Glycerolipid metabolism_Homo sapiens_hsa005610.35423430
114Rap1 signaling pathway_Homo sapiens_hsa040150.34888185
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34841704
116Arachidonic acid metabolism_Homo sapiens_hsa005900.34605328
117Oocyte meiosis_Homo sapiens_hsa041140.34006498
118VEGF signaling pathway_Homo sapiens_hsa043700.33580307
119Metabolic pathways_Homo sapiens_hsa011000.33498183
120Nitrogen metabolism_Homo sapiens_hsa009100.33427516
121Notch signaling pathway_Homo sapiens_hsa043300.32161646
122Endocytosis_Homo sapiens_hsa041440.32021850
123Calcium signaling pathway_Homo sapiens_hsa040200.31997886
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31980771
125Tuberculosis_Homo sapiens_hsa051520.31605431
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31022911
127ErbB signaling pathway_Homo sapiens_hsa040120.30564182
128Melanoma_Homo sapiens_hsa052180.28718020
129Glioma_Homo sapiens_hsa052140.27734291
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.27299840
131Basal transcription factors_Homo sapiens_hsa030220.26954686
132Insulin resistance_Homo sapiens_hsa049310.26491497
133Renin secretion_Homo sapiens_hsa049240.25538620
134Cell cycle_Homo sapiens_hsa041100.25458822
135Sphingolipid metabolism_Homo sapiens_hsa006000.24938403
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24453112
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.24157697
138FoxO signaling pathway_Homo sapiens_hsa040680.22630143
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22437322
140Prolactin signaling pathway_Homo sapiens_hsa049170.22425182
141Long-term potentiation_Homo sapiens_hsa047200.22356186
142Oxytocin signaling pathway_Homo sapiens_hsa049210.21574144
143PPAR signaling pathway_Homo sapiens_hsa033200.21470101
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20881640
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.19307906
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19171384
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19112259
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17779547
149N-Glycan biosynthesis_Homo sapiens_hsa005100.17689540
150Biosynthesis of amino acids_Homo sapiens_hsa012300.17592096
151Chemical carcinogenesis_Homo sapiens_hsa052040.17349247
152TGF-beta signaling pathway_Homo sapiens_hsa043500.13617279
153Linoleic acid metabolism_Homo sapiens_hsa005910.13238170
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13076286
155Tyrosine metabolism_Homo sapiens_hsa003500.11690531
156Dorso-ventral axis formation_Homo sapiens_hsa043200.11149313
157One carbon pool by folate_Homo sapiens_hsa006700.11134495
158MAPK signaling pathway_Homo sapiens_hsa040100.10567292
159Retinol metabolism_Homo sapiens_hsa008300.10032292
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09874403
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.09562202
162RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06961188
163Mineral absorption_Homo sapiens_hsa049780.05981574
164Non-homologous end-joining_Homo sapiens_hsa034500.04352159

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