MSMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primary alcohol catabolic process (GO:0034310)9.85082203
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060529.72866657
3regulation of acrosome reaction (GO:0060046)9.12822595
4axoneme assembly (GO:0035082)9.09835760
5diterpenoid biosynthetic process (GO:0016102)8.93242506
6beta-amyloid metabolic process (GO:0050435)8.54941766
7left/right pattern formation (GO:0060972)8.29098869
8ovulation cycle (GO:0042698)8.24623498
9angiotensin maturation (GO:0002003)8.08028375
10ethanol metabolic process (GO:0006067)7.73406333
11replicative senescence (GO:0090399)7.07943136
12response to testosterone (GO:0033574)6.88890511
13epithelial cell maturation (GO:0002070)6.61560900
14ethanol oxidation (GO:0006069)6.54167962
15prostate gland epithelium morphogenesis (GO:0060740)6.50058520
16one-carbon compound transport (GO:0019755)6.48025539
17regulation of cilium movement (GO:0003352)6.39525280
18terpenoid biosynthetic process (GO:0016114)6.36524267
19intestinal epithelial cell development (GO:0060576)6.30945150
20negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)6.12493832
21retinoic acid metabolic process (GO:0042573)5.83922519
22left/right axis specification (GO:0070986)5.79608485
23microtubule bundle formation (GO:0001578)5.73525887
24epithelial cell differentiation involved in prostate gland development (GO:0060742)5.73235872
25regulation of clathrin-mediated endocytosis (GO:2000369)5.69698116
26N-acetylneuraminate metabolic process (GO:0006054)5.66152130
27mannose metabolic process (GO:0006013)5.63501166
28Golgi transport vesicle coating (GO:0048200)5.60691045
29COPI coating of Golgi vesicle (GO:0048205)5.60691045
30ventricular system development (GO:0021591)5.57827279
31intraciliary transport (GO:0042073)5.48197118
32retinol metabolic process (GO:0042572)5.08490940
33cilium organization (GO:0044782)5.08170708
34lung epithelium development (GO:0060428)5.07470180
35tolerance induction (GO:0002507)5.07012536
36transepithelial transport (GO:0070633)4.99445482
37cilium assembly (GO:0042384)4.94641535
38transcytosis (GO:0045056)4.90607302
39regulation of calcium ion-dependent exocytosis (GO:0017158)4.79241018
40artery development (GO:0060840)4.75549787
41regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.73915349
42regulation of microtubule-based movement (GO:0060632)4.73207355
43establishment of apical/basal cell polarity (GO:0035089)4.73127960
44centriole assembly (GO:0098534)4.64795152
45sperm capacitation (GO:0048240)4.60610908
46primary alcohol metabolic process (GO:0034308)4.58459217
47ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.56990849
48response to xenobiotic stimulus (GO:0009410)4.56788479
49negative regulation of T cell differentiation in thymus (GO:0033085)4.53466766
50regulation of calcium ion import (GO:0090279)4.49264042
51glomerular epithelial cell development (GO:0072310)4.47949669
52negative regulation of B cell mediated immunity (GO:0002713)4.47595857
53negative regulation of immunoglobulin mediated immune response (GO:0002890)4.47595857
54valine metabolic process (GO:0006573)4.42960619
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.41020258
56positive regulation of respiratory burst (GO:0060267)4.39231993
57fucose metabolic process (GO:0006004)4.38724439
58negative regulation of humoral immune response (GO:0002921)4.35454962
59positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.31305772
60nucleotide-sugar metabolic process (GO:0009225)4.27919387
61protein targeting to Golgi (GO:0000042)4.24680431
62L-serine transport (GO:0015825)4.22341796
63protein localization to cilium (GO:0061512)4.20223535
64regulation of receptor binding (GO:1900120)4.18931634
65positive regulation of tolerance induction (GO:0002645)4.17776834
66sulfate transmembrane transport (GO:1902358)4.09627299
67regulation of germinal center formation (GO:0002634)4.07001798
68response to UV-B (GO:0010224)4.05979947
69establishment of monopolar cell polarity (GO:0061162)4.05151596
70establishment or maintenance of monopolar cell polarity (GO:0061339)4.05151596
71cellular component assembly involved in morphogenesis (GO:0010927)3.97094438
72activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.95932908
73negative regulation of receptor-mediated endocytosis (GO:0048261)3.94321755
74protein retention in ER lumen (GO:0006621)3.93110424
75glutathione derivative metabolic process (GO:1901685)3.92975930
76glutathione derivative biosynthetic process (GO:1901687)3.92975930
77microtubule-based movement (GO:0007018)3.90760936
78retrograde transport, vesicle recycling within Golgi (GO:0000301)3.90001204
79cell volume homeostasis (GO:0006884)3.85122256
80progesterone metabolic process (GO:0042448)3.83722073
81O-glycan processing (GO:0016266)3.80703035
82cell projection assembly (GO:0030031)3.79288108
83establishment of protein localization to Golgi (GO:0072600)3.78915871
84regulation of interleukin-5 production (GO:0032674)3.78803658
85cytoskeletal anchoring at plasma membrane (GO:0007016)3.78197545
86positive regulation of nuclease activity (GO:0032075)3.76950667
87multicellular organismal water homeostasis (GO:0050891)3.73085638
88cellular response to zinc ion (GO:0071294)3.67438141
89serine transport (GO:0032329)3.64390828
90glycoside metabolic process (GO:0016137)3.63856740
91branching involved in mammary gland duct morphogenesis (GO:0060444)3.63189742
92COPII vesicle coating (GO:0048208)3.62116753
93retinal metabolic process (GO:0042574)3.61168525
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58130646
95nucleoside diphosphate phosphorylation (GO:0006165)3.54221705
96cytoplasmic microtubule organization (GO:0031122)3.53994650
97cilium morphogenesis (GO:0060271)3.51195723
98hypotonic response (GO:0006971)3.48942789
99glucosamine-containing compound metabolic process (GO:1901071)3.45708382
100hydrogen peroxide biosynthetic process (GO:0050665)3.42453988
101regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.39361912
102regulation of nuclease activity (GO:0032069)3.39052619
103regulation of pH (GO:0006885)3.38314459
104establishment of tissue polarity (GO:0007164)3.37317123
105establishment of planar polarity (GO:0001736)3.37317123
106regulation of interleukin-13 production (GO:0032656)3.37239352
107exogenous drug catabolic process (GO:0042738)3.35712781
108antibacterial humoral response (GO:0019731)3.33348217
109negative regulation of inclusion body assembly (GO:0090084)3.32702005
110anterior/posterior axis specification, embryo (GO:0008595)3.31401439
111oligosaccharide biosynthetic process (GO:0009312)3.27376168
112regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.26456470
113negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)3.25754733
114endoplasmic reticulum unfolded protein response (GO:0030968)3.24235216
115water homeostasis (GO:0030104)3.21144731
116iron ion import (GO:0097286)3.21121348
117retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20853220
118vesicle coating (GO:0006901)3.18117098
119mitotic cell cycle arrest (GO:0071850)3.15715267
120cellular response to unfolded protein (GO:0034620)3.13444601
121activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.13038880
122regulation of tolerance induction (GO:0002643)3.12880578
123innate immune response in mucosa (GO:0002227)3.12224474
124pyrimidine-containing compound transmembrane transport (GO:0072531)3.12221781
125regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.11559978
126detection of mechanical stimulus involved in sensory perception (GO:0050974)3.10907566
127positive regulation of steroid hormone secretion (GO:2000833)3.10617478
128sulfate transport (GO:0008272)3.10600192
129ER-nucleus signaling pathway (GO:0006984)3.10350308
130extracellular negative regulation of signal transduction (GO:1900116)3.07742522
131extracellular regulation of signal transduction (GO:1900115)3.07742522
132N-glycan processing (GO:0006491)3.07706877
133lung secretory cell differentiation (GO:0061140)3.06017654
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05454532
135antimicrobial humoral response (GO:0019730)3.05130446
136reactive oxygen species biosynthetic process (GO:1903409)3.03993022
137glandular epithelial cell differentiation (GO:0002067)3.03663405
138pharyngeal system development (GO:0060037)3.03337353
139positive regulation of smoothened signaling pathway (GO:0045880)3.00572353
140excretion (GO:0007588)2.99312721
141positive regulation of glycoprotein metabolic process (GO:1903020)2.98731445
142hyperosmotic response (GO:0006972)2.98183535
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.97791319
144negative regulation of glycogen biosynthetic process (GO:0045719)2.96656984
145response to endoplasmic reticulum stress (GO:0034976)2.96174237
146vitamin transmembrane transport (GO:0035461)2.94798961
147microtubule depolymerization (GO:0007019)2.94456703
148glutathione biosynthetic process (GO:0006750)2.93229300
149ear development (GO:0043583)2.91996009
150retinal ganglion cell axon guidance (GO:0031290)2.91277797
151L-fucose catabolic process (GO:0042355)2.91027319
152fucose catabolic process (GO:0019317)2.91027319
153L-fucose metabolic process (GO:0042354)2.91027319
154amino sugar metabolic process (GO:0006040)2.89510488
155microtubule polymerization or depolymerization (GO:0031109)2.88933372
156regulation of autophagic vacuole assembly (GO:2000785)2.87555618
157apical protein localization (GO:0045176)2.86213431
158glutathione metabolic process (GO:0006749)2.84368404
159cellular response to topologically incorrect protein (GO:0035967)2.82535440
160sodium ion homeostasis (GO:0055078)2.82008750
161calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.81260717
162cell aggregation (GO:0098743)2.80737215
163cartilage condensation (GO:0001502)2.80737215
164carnitine metabolic process (GO:0009437)2.77894427
165regulation of microtubule depolymerization (GO:0031114)2.76941277
166protein N-linked glycosylation via asparagine (GO:0018279)2.76377595
167regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75270474
168lung cell differentiation (GO:0060479)2.74811714
169cellular aldehyde metabolic process (GO:0006081)2.74732931
170hydrogen peroxide catabolic process (GO:0042744)2.74474116
171regulation of protein glycosylation (GO:0060049)2.74449410
172aldehyde catabolic process (GO:0046185)2.73439876
173peptidyl-asparagine modification (GO:0018196)2.73306866
174sulfur amino acid catabolic process (GO:0000098)2.72199393
175intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.72042432
176protein targeting to lysosome (GO:0006622)2.71495632
177establishment of protein localization to vacuole (GO:0072666)2.71495632
178protein targeting to vacuole (GO:0006623)2.71495632
179nonribosomal peptide biosynthetic process (GO:0019184)2.71274630
180positive regulation of bone resorption (GO:0045780)2.70396217
181regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68999883
182regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.66844793
183protein O-linked glycosylation (GO:0006493)2.65946360
184sperm motility (GO:0030317)2.64294763
185lateral sprouting from an epithelium (GO:0060601)2.63000961
186polyol transport (GO:0015791)2.62996360
187phosphatidylcholine biosynthetic process (GO:0006656)2.61445905
188extracellular fibril organization (GO:0043206)2.61190692
189doxorubicin metabolic process (GO:0044598)2.59926198
190daunorubicin metabolic process (GO:0044597)2.59926198
191axonemal dynein complex assembly (GO:0070286)19.8294311
192cilium or flagellum-dependent cell motility (GO:0001539)15.3860294
193cilium movement (GO:0003341)13.6676974
194motile cilium assembly (GO:0044458)13.3085404
195epithelial cilium movement (GO:0003351)12.0530207
196epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.9796040
197UDP-N-acetylglucosamine metabolic process (GO:0006047)10.7361885
198branching involved in prostate gland morphogenesis (GO:0060442)10.1403078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.35163536
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.45000296
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.53230684
4ZNF217_24962896_ChIP-Seq_MCF-7_Human3.52059467
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.38931537
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08447210
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.06550524
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.94236324
9ZNF263_19887448_ChIP-Seq_K562_Human2.93324223
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75230422
11SOX2_20726797_ChIP-Seq_SW620_Human2.56357626
12GATA1_22025678_ChIP-Seq_K562_Human2.36391736
13AHR_22903824_ChIP-Seq_MCF-7_Human2.23834096
14CTNNB1_20460455_ChIP-Seq_HCT116_Human2.19259253
15* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.18627843
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.15463807
17ARNT_22903824_ChIP-Seq_MCF-7_Human2.14455860
18AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.13150836
19GATA4_25053715_ChIP-Seq_YYC3_Human2.09479742
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08528686
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06689307
22RUNX1_27514584_Chip-Seq_MCF-7_Human2.05542075
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.03151809
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02051372
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00314517
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00314517
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00314517
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.96806868
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96465588
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.96311031
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91216536
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90143350
33GATA6_25053715_ChIP-Seq_YYC3_Human1.89225130
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.86472019
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86269824
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83820742
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81638191
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.78654545
39STAT1_20625510_ChIP-Seq_HELA_Human1.78462251
40CLOCK_20551151_ChIP-Seq_293T_Human1.73484239
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.72307022
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.72038242
43SMC4_20622854_ChIP-Seq_HELA_Human1.71636443
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69202421
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.67228355
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64880598
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64524536
48* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.58515016
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55886106
50FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55592944
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55346015
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54683449
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52155436
54TP63_22573176_ChIP-Seq_HFKS_Human1.47967679
55* GATA3_24758297_ChIP-Seq_MCF-7_Human1.45668988
56AR_21909140_ChIP-Seq_LNCAP_Human1.43251512
57CHD1_26751641_Chip-Seq_LNCaP_Human1.42534730
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42254050
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40199439
60RAD21_21589869_ChIP-Seq_MESCs_Mouse1.40081264
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39512706
62GATA1_19941826_ChIP-Seq_K562_Human1.37024953
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.36999511
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35515284
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.32813946
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30670066
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28890410
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28890410
69CDX2_22108803_ChIP-Seq_LS180_Human1.28397805
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.28167512
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.27698260
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24526637
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24356648
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24267188
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22258284
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21731932
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20734815
78* TP63_23658742_ChIP-Seq_EP156T_Human1.19388795
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17518970
80CREB1_26743006_Chip-Seq_LNCaP_Human1.15838535
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15761397
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15511461
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11801872
84SMRT_27268052_Chip-Seq_Bcells_Human1.11565481
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.11166646
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.11166646
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10807489
88ELF5_23300383_ChIP-Seq_T47D_Human1.08823904
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08662163
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07813270
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07744254
92ETV1_20927104_ChIP-Seq_GIST48_Human1.07025969
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06852927
94FOXA1_25552417_ChIP-Seq_VCAP_Human1.06748085
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05597398
96CTCF_27219007_Chip-Seq_Bcells_Human1.04290521
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03531554
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.02403107
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02200853
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.01876748
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01341142
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00848160
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98541638
104LXR_22292898_ChIP-Seq_THP-1_Human0.98377977
105RACK7_27058665_Chip-Seq_MCF-7_Human0.98072638
106P68_20966046_ChIP-Seq_HELA_Human0.97924360
107SMAD4_21799915_ChIP-Seq_A2780_Human0.97374313
108CTCF_20526341_ChIP-Seq_ESCs_Human0.97170971
109GATA2_19941826_ChIP-Seq_K562_Human0.97170721
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96633887
111KLF5_25053715_ChIP-Seq_YYC3_Human0.96239471
112CEBPB_22108803_ChIP-Seq_LS180_Human0.96190840
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95672035
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94625907
115AR_25329375_ChIP-Seq_VCAP_Human0.93226804
116HNFA_21074721_ChIP-Seq_CACO-2_Human0.92788885
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92448904
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.91686905
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.91475453
120RXR_22108803_ChIP-Seq_LS180_Human0.91159273
121CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90755767
122PHF8_20622853_ChIP-Seq_HELA_Human0.88547562
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87678178
124PHF8_20622854_ChIP-Seq_HELA_Human0.86949398
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86757512
126CJUN_26792858_Chip-Seq_BT549_Human0.85895116
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85640224
128DROSHA_22980978_ChIP-Seq_HELA_Human0.85587076
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85354501
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85169506
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85116419
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85024007
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84776263
134P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83938037
135RBPJ_21746931_ChIP-Seq_IB4_Human0.83575957
136CBX2_22325352_ChIP-Seq_293T-Rex_Human0.82080959
137PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81548193
138ZNF274_21170338_ChIP-Seq_K562_Hela0.81350268
139TP53_18474530_ChIP-ChIP_U2OS_Human0.81106122
140GATA6_21074721_ChIP-Seq_CACO-2_Human0.80461512
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80429957
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80406230
143P300_27268052_Chip-Seq_Bcells_Human0.80147239
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79496020
145VDR_22108803_ChIP-Seq_LS180_Human0.79478508
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79156648
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78259514
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.77694615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.00355637
2MP0010386_abnormal_urinary_bladder5.99908864
3MP0002653_abnormal_ependyma_morphology5.25343486
4MP0005310_abnormal_salivary_gland4.97886101
5MP0009780_abnormal_chondrocyte_physiolo4.89663720
6MP0002132_abnormal_respiratory_system4.30524842
7MP0001873_stomach_inflammation3.70658097
8MP0000537_abnormal_urethra_morphology3.63638937
9MP0001485_abnormal_pinna_reflex3.51144570
10MP0004885_abnormal_endolymph3.51036010
11MP0002166_altered_tumor_susceptibility3.44520847
12MP0002009_preneoplasia3.29891557
13MP0008789_abnormal_olfactory_epithelium3.20580360
14MP0001984_abnormal_olfaction3.14186604
15MP0002277_abnormal_respiratory_mucosa3.05771674
16MP0004133_heterotaxia2.75262802
17MP0004264_abnormal_extraembryonic_tissu2.66609116
18MP0002006_tumorigenesis2.64110092
19MP0000604_amyloidosis2.59871161
20MP0005623_abnormal_meninges_morphology2.50410029
21MP0005083_abnormal_biliary_tract2.50334834
22MP0005647_abnormal_sex_gland2.42791459
23MP0005275_abnormal_skin_tensile2.21994000
24MP0000465_gastrointestinal_hemorrhage2.07933673
25MP0006072_abnormal_retinal_apoptosis2.07738783
26MP0005499_abnormal_olfactory_system2.03824204
27MP0005394_taste/olfaction_phenotype2.03824204
28MP0002168_other_aberrant_phenotype2.03528362
29MP0000383_abnormal_hair_follicle2.00838326
30MP0004947_skin_inflammation1.96223844
31MP0001919_abnormal_reproductive_system1.95677325
32MP0001765_abnormal_ion_homeostasis1.94978604
33MP0010678_abnormal_skin_adnexa1.87936689
34MP0002909_abnormal_adrenal_gland1.87499891
35MP0000678_abnormal_parathyroid_gland1.85371022
36MP0000538_abnormal_urinary_bladder1.85196948
37MP0001666_abnormal_nutrient_absorption1.82030625
38MP0002139_abnormal_hepatobiliary_system1.72211666
39MP0005165_increased_susceptibility_to1.71190122
40MP0001346_abnormal_lacrimal_gland1.61115295
41MP0003878_abnormal_ear_physiology1.58005564
42MP0005377_hearing/vestibular/ear_phenot1.58005564
43MP0002160_abnormal_reproductive_system1.53776490
44MP0009384_cardiac_valve_regurgitation1.51843252
45MP0000747_muscle_weakness1.47933315
46MP0009379_abnormal_foot_pigmentation1.47748114
47MP0000613_abnormal_salivary_gland1.45100683
48MP0002282_abnormal_trachea_morphology1.42754145
49MP0000462_abnormal_digestive_system1.40022570
50MP0002796_impaired_skin_barrier1.40003960
51MP0003300_gastrointestinal_ulcer1.36498179
52MP0005164_abnormal_response_to1.33367773
53MP0003303_peritoneal_inflammation1.32001220
54MP0005395_other_phenotype1.30439242
55MP0010352_gastrointestinal_tract_polyps1.27213876
56MP0002249_abnormal_larynx_morphology1.21704163
57MP0009643_abnormal_urine_homeostasis1.17513201
58MP0005220_abnormal_exocrine_pancreas1.16708424
59MP0005085_abnormal_gallbladder_physiolo1.16169919
60MP0004883_abnormal_blood_vessel1.13969675
61MP0001299_abnormal_eye_distance/1.13833477
62MP0001756_abnormal_urination1.13057162
63MP0003315_abnormal_perineum_morphology1.12753916
64MP0003705_abnormal_hypodermis_morpholog1.11931824
65MP0002233_abnormal_nose_morphology1.07986119
66MP0004742_abnormal_vestibular_system1.07779730
67MP0005058_abnormal_lysosome_morphology1.03866878
68MP0005381_digestive/alimentary_phenotyp1.03187222
69MP0003183_abnormal_peptide_metabolism1.02211158
70MP0004130_abnormal_muscle_cell1.01946492
71MP0003866_abnormal_defecation1.01662023
72MP0010030_abnormal_orbit_morphology0.97488946
73MP0000681_abnormal_thyroid_gland0.94004319
74MP0005187_abnormal_penis_morphology0.93221089
75MP0002098_abnormal_vibrissa_morphology0.92879270
76MP0004019_abnormal_vitamin_homeostasis0.92640614
77MP0004185_abnormal_adipocyte_glucose0.91822321
78MP0001849_ear_inflammation0.90368195
79MP0003075_altered_response_to0.88977689
80MP0003045_fibrosis0.87698286
81MP0008438_abnormal_cutaneous_collagen0.87222911
82MP0005319_abnormal_enzyme/_coenzyme0.86847168
83MP0001664_abnormal_digestion0.86416065
84MP0003656_abnormal_erythrocyte_physiolo0.85716824
85MP0005636_abnormal_mineral_homeostasis0.85679458
86MP0000467_abnormal_esophagus_morphology0.85601887
87MP0002822_catalepsy0.84621163
88MP0005389_reproductive_system_phenotype0.81306219
89MP0001663_abnormal_digestive_system0.81122528
90MP0005503_abnormal_tendon_morphology0.80998066
91MP0004145_abnormal_muscle_electrophysio0.77657534
92MP0010329_abnormal_lipoprotein_level0.76913163
93MP0005367_renal/urinary_system_phenotyp0.75621404
94MP0000516_abnormal_urinary_system0.75621404
95MP0005365_abnormal_bile_salt0.74956645
96MP0003937_abnormal_limbs/digits/tail_de0.74899735
97MP0009765_abnormal_xenobiotic_induced0.73884306
98MP0002735_abnormal_chemical_nociception0.73018293
99MP0009763_increased_sensitivity_to0.72708767
100MP0002111_abnormal_tail_morphology0.70204535
101MP0005023_abnormal_wound_healing0.67665042
102MP0001270_distended_abdomen0.67581061
103MP0003566_abnormal_cell_adhesion0.67256870
104MP0005409_darkened_coat_color0.67169859
105MP0006054_spinal_hemorrhage0.65406978
106MP0000566_synostosis0.65179600
107MP0003950_abnormal_plasma_membrane0.64455238
108MP0002638_abnormal_pupillary_reflex0.63191309
109MP0000230_abnormal_systemic_arterial0.62670326
110MP0003011_delayed_dark_adaptation0.62465585
111MP0000534_abnormal_ureter_morphology0.62212452
112MP0005166_decreased_susceptibility_to0.61773664
113MP0000470_abnormal_stomach_morphology0.61143453
114MP0005248_abnormal_Harderian_gland0.59332091
115MP0002269_muscular_atrophy0.58983628
116MP0002734_abnormal_mechanical_nocicepti0.58218309
117MP0000377_abnormal_hair_follicle0.58012010
118MP0005408_hypopigmentation0.57025706
119MP0003941_abnormal_skin_development0.56614551
120MP0003806_abnormal_nucleotide_metabolis0.55622942
121MP0005666_abnormal_adipose_tissue0.55245477
122MP0002896_abnormal_bone_mineralization0.54479811
123MP0000627_abnormal_mammary_gland0.53697684
124MP0002396_abnormal_hematopoietic_system0.53649731
125MP0002295_abnormal_pulmonary_circulatio0.52482946
126MP0002136_abnormal_kidney_physiology0.52021004
127MP0005330_cardiomyopathy0.51917675
128MP0000163_abnormal_cartilage_morphology0.51435710
129MP0001929_abnormal_gametogenesis0.51156744
130MP0004043_abnormal_pH_regulation0.51131290
131MP0004782_abnormal_surfactant_physiolog0.50679104
132MP0001216_abnormal_epidermal_layer0.50548522
133MP0005076_abnormal_cell_differentiation0.49798557
134MP0002876_abnormal_thyroid_physiology0.49593546
135MP0003698_abnormal_male_reproductive0.48752985
136MP0002557_abnormal_social/conspecific_i0.48637706
137MP0009250_abnormal_appendicular_skeleto0.48371893
138MP0004036_abnormal_muscle_relaxation0.48313944
139MP0003191_abnormal_cellular_cholesterol0.47873658
140MP0003890_abnormal_embryonic-extraembry0.47656745
141MP0005501_abnormal_skin_physiology0.47415067
142MP0002405_respiratory_system_inflammati0.46315855
143MP0002133_abnormal_respiratory_system0.45652250
144MP0005388_respiratory_system_phenotype0.45652250
145MP0003186_abnormal_redox_activity0.45337352
146MP0008004_abnormal_stomach_pH0.45259402
147MP0000477_abnormal_intestine_morphology0.44756806
148MP0001944_abnormal_pancreas_morphology0.44214556
149MP0006082_CNS_inflammation0.44029981
150MP0005376_homeostasis/metabolism_phenot0.43467846
151MP0002115_abnormal_skeleton_extremities0.43008615
152MP0002135_abnormal_kidney_morphology0.42069906
153MP0004087_abnormal_muscle_fiber0.41600366
154MP0008875_abnormal_xenobiotic_pharmacok0.39170744
155MP0000609_abnormal_liver_physiology0.39106128
156MP0003453_abnormal_keratinocyte_physiol0.38922573
157MP0010155_abnormal_intestine_physiology0.38702802
158MP0002060_abnormal_skin_morphology0.38576015

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.58222370
2Bronchiectasis (HP:0002110)7.51681689
3Aplasia involving bones of the upper limbs (HP:0009823)6.82207555
4Aplasia of the phalanges of the hand (HP:0009802)6.82207555
5Aplasia involving bones of the extremities (HP:0009825)6.82207555
6Nasal polyposis (HP:0100582)6.71146487
7Hypoplasia of the uterus (HP:0000013)6.53237827
8Fibular aplasia (HP:0002990)6.36086475
9Abnormality of the phalanges of the 2nd finger (HP:0009541)6.19853769
10Abnormality of cochlea (HP:0000375)6.15815732
11Abnormality of the proximal phalanges of the hand (HP:0009834)5.69284882
12Abnormality of the nasal mucosa (HP:0000433)5.58288730
13Abnormality of the 2nd finger (HP:0004100)5.36173475
14Steatorrhea (HP:0002570)4.82002248
15Aplasia/hypoplasia of the uterus (HP:0008684)4.53817027
16Bronchitis (HP:0012387)4.49979743
17Exocrine pancreatic insufficiency (HP:0001738)4.49041323
18Hypoplastic nipples (HP:0002557)4.46907431
192-3 toe syndactyly (HP:0004691)4.44346074
20Abnormality of the middle phalanges of the toes (HP:0010183)4.35732274
21Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.33448494
22Adactyly (HP:0009776)4.32508286
23Recurrent sinusitis (HP:0011108)4.31364052
24Morphological abnormality of the inner ear (HP:0011390)4.26210736
25Short hallux (HP:0010109)4.24511330
26Congenital sensorineural hearing impairment (HP:0008527)4.24464453
27Infertility (HP:0000789)4.23981162
28Thoracolumbar scoliosis (HP:0002944)4.11041433
29Chronic sinusitis (HP:0011109)4.10435443
30Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.09364976
31Fat malabsorption (HP:0002630)4.01844436
32Male infertility (HP:0003251)3.99332067
33Aplasia/Hypoplasia of the hallux (HP:0008362)3.94093459
34Hyperactive renin-angiotensin system (HP:0000841)3.86667550
35Recurrent otitis media (HP:0000403)3.86563766
36Rimmed vacuoles (HP:0003805)3.81558636
37Limb-girdle muscle atrophy (HP:0003797)3.78702533
38Thyroid carcinoma (HP:0002890)3.69238561
39Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.68414379
40Mucopolysacchariduria (HP:0008155)3.64882503
41Urinary glycosaminoglycan excretion (HP:0003541)3.64882503
42Vacuolated lymphocytes (HP:0001922)3.55637394
43Occipital encephalocele (HP:0002085)3.33381162
44Aplasia/Hypoplasia of the fibula (HP:0006492)3.32355779
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.27658246
46Abnormality of mucopolysaccharide metabolism (HP:0011020)3.24623512
47Abnormality of polysaccharide metabolism (HP:0011012)3.24623512
48Abnormality of glycosaminoglycan metabolism (HP:0004371)3.24623512
49Hypoplasia of the ulna (HP:0003022)3.22653467
50Symphalangism affecting the phalanges of the hand (HP:0009773)3.12544003
51Atelectasis (HP:0100750)3.08948752
52Pancreatic fibrosis (HP:0100732)3.05638189
53True hermaphroditism (HP:0010459)3.02379354
54Chronic otitis media (HP:0000389)3.02306856
55Rectal prolapse (HP:0002035)3.01799123
56Long toe (HP:0010511)3.00689732
57Abnormality of the phalanges of the 5th finger (HP:0004213)2.98393929
58Protuberant abdomen (HP:0001538)2.95331151
59Abnormality of the axillary hair (HP:0100134)2.88545470
60Abnormality of secondary sexual hair (HP:0009888)2.88545470
61Submucous cleft hard palate (HP:0000176)2.74147924
62Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.65048199
63Cystic liver disease (HP:0006706)2.57848873
64Synostosis of carpal bones (HP:0005048)2.51469924
65Aplasia/Hypoplasia of the ulna (HP:0006495)2.46917169
66Renal salt wasting (HP:0000127)2.40324012
67Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.39674837
68Pancreatic cysts (HP:0001737)2.38942815
69Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38828322
70Molar tooth sign on MRI (HP:0002419)2.38456646
71Abnormality of midbrain morphology (HP:0002418)2.38456646
72Pancreatitis (HP:0001733)2.35966193
73Broad hallux (HP:0010055)2.33433406
74Hyperphosphatemia (HP:0002905)2.33401542
75Hypergonadotropic hypogonadism (HP:0000815)2.31139127
76Distal arthrogryposis (HP:0005684)2.31128743
77Short femoral neck (HP:0100864)2.30106838
78Nephronophthisis (HP:0000090)2.29260408
79Decreased circulating renin level (HP:0003351)2.25324269
80Tarsal synostosis (HP:0008368)2.25123511
81Dysostosis multiplex (HP:0000943)2.23497029
82Hyperparathyroidism (HP:0000843)2.21648050
83Testicular atrophy (HP:0000029)2.20759325
84Postaxial foot polydactyly (HP:0001830)2.18525186
85Sleep apnea (HP:0010535)2.14337160
86Tracheal stenosis (HP:0002777)2.10095587
87Tubulointerstitial nephritis (HP:0001970)2.09704686
88Hyperkalemia (HP:0002153)2.08747133
89Chronic hepatic failure (HP:0100626)2.08285928
90Aortic aneurysm (HP:0004942)2.07536043
91Ulnar deviation of finger (HP:0009465)2.06864395
92Abdominal distention (HP:0003270)2.06273393
93Abnormality of the pleura (HP:0002103)2.05489330
94Abnormality of the epiphyses of the hand (HP:0005924)2.04561218
95Cutaneous finger syndactyly (HP:0010554)2.04040621
96Bell-shaped thorax (HP:0001591)2.02236768
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02034501
98Limb-girdle muscle weakness (HP:0003325)2.00347356
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4168062
100Abnormal respiratory motile cilium morphology (HP:0005938)11.0641077
101Abnormal respiratory epithelium morphology (HP:0012253)11.0641077
102Abnormal respiratory motile cilium physiology (HP:0012261)10.8922191
103Dynein arm defect of respiratory motile cilia (HP:0012255)10.5171198
104Absent/shortened dynein arms (HP:0200106)10.5171198
105Abnormal ciliary motility (HP:0012262)10.4633686
106Rhinitis (HP:0012384)10.3336732
107Calf muscle hypertrophy (HP:0008981)1.98044646
108Synostosis involving bones of the feet (HP:0009140)1.97725293
109Synostosis involving bones of the lower limbs (HP:0009138)1.97725293
110Lip pit (HP:0100267)1.97556440
111Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.95157792
112Abnormality of small intestinal villus morphology (HP:0011472)1.92333285
113Villous atrophy (HP:0011473)1.92333285
114Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.92298816
115Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.91712616
116Absent frontal sinuses (HP:0002688)1.91527374
117Hyperaldosteronism (HP:0000859)1.90566443
118Aplasia/hypoplasia of the femur (HP:0005613)1.90435874
119Smooth philtrum (HP:0000319)1.90249517
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86161863
121Chin dimple (HP:0010751)1.85805948
122Broad toe (HP:0001837)1.85326036
123Carpal synostosis (HP:0009702)1.84429959
124Aplasia/Hypoplasia of the nipples (HP:0006709)1.83134504
125Abnormality of the renal medulla (HP:0100957)1.82284012
126EMG: myopathic abnormalities (HP:0003458)1.81831654
127Male pseudohermaphroditism (HP:0000037)1.81716243
128Deviation of the hallux (HP:0010051)1.80919569
129Abnormality of chloride homeostasis (HP:0011422)1.80046503
130Papillary thyroid carcinoma (HP:0002895)1.79072504
131Barrel-shaped chest (HP:0001552)1.78307408
132Beaking of vertebral bodies (HP:0004568)1.76639813
133Congenital hepatic fibrosis (HP:0002612)1.75468732
134Increased IgE level (HP:0003212)1.75437197
135Abnormality of renin-angiotensin system (HP:0000847)1.74027771
136Anencephaly (HP:0002323)1.73991272
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.71381247
138Prostate neoplasm (HP:0100787)1.70780687
139Forearm undergrowth (HP:0009821)1.69342426
140Recurrent bronchitis (HP:0002837)1.69312938
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.68413311
142Abnormal foot bone ossification (HP:0010675)1.68094652
143Muscle hypertrophy of the lower extremities (HP:0008968)1.67751815
144Mildly elevated creatine phosphokinase (HP:0008180)1.66563565
145Abnormality of the distal phalanges of the toes (HP:0010182)1.66352205
146Abnormality of the middle phalanges of the hand (HP:0009833)1.63689086
147Hallux valgus (HP:0001822)1.62843955
148Neoplasm of the thyroid gland (HP:0100031)1.62786760
149Asplenia (HP:0001746)1.62187524
150Nephropathy (HP:0000112)1.61667395
151Medial flaring of the eyebrow (HP:0010747)1.54454379
152Furrowed tongue (HP:0000221)1.53503365
153Hyponatremia (HP:0002902)1.51507718
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50010333
155Hypokalemic alkalosis (HP:0001949)1.49225336
156Congenital primary aphakia (HP:0007707)1.47768568
157Tubular atrophy (HP:0000092)1.46718945
158Bifid scrotum (HP:0000048)1.44550941
159Oculomotor apraxia (HP:0000657)1.44528658
160Gait imbalance (HP:0002141)1.43489363
161Abnormality of monocarboxylic acid metabolism (HP:0010996)1.41459462
162Hand muscle atrophy (HP:0009130)1.40943252
163Abnormality of the dental root (HP:0006486)1.38627223
164Taurodontia (HP:0000679)1.38627223
165Abnormality of permanent molar morphology (HP:0011071)1.38627223
166Sclerocornea (HP:0000647)1.38385023
167Flat acetabular roof (HP:0003180)1.37514723
168Postaxial hand polydactyly (HP:0001162)1.37402708
169Popliteal pterygium (HP:0009756)1.35293549
170Glucose intolerance (HP:0000833)1.32690122
171Short nail (HP:0001799)1.28881361
172Abnormality of molar (HP:0011077)1.27338431
173Abnormality of molar morphology (HP:0011070)1.27338431
174Nephrogenic diabetes insipidus (HP:0009806)1.26200695
175Short thorax (HP:0010306)1.23397129
176Abnormality of the dental pulp (HP:0006479)1.21545532
177Median cleft lip (HP:0000161)1.20545846
178Spinal cord compression (HP:0002176)1.18709883
179Obstructive sleep apnea (HP:0002870)1.18416055
180Abnormality of the frontal sinuses (HP:0002687)1.16905868
181Aplasia of the musculature (HP:0100854)1.16784986
182Abnormality of sodium homeostasis (HP:0010931)1.16405339
183Fetal akinesia sequence (HP:0001989)1.15910955
184Vascular calcification (HP:0004934)1.15692618
185Abdominal situs inversus (HP:0003363)1.13823752
186Abnormality of abdominal situs (HP:0011620)1.13823752
187Malnutrition (HP:0004395)1.12213959
188Cone-rod dystrophy (HP:0000548)1.11414760
189Carpal bone hypoplasia (HP:0001498)1.09010204
190Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.08689354
191Stridor (HP:0010307)1.05328749
192Muscle fiber splitting (HP:0003555)1.04597696
193Tubulointerstitial abnormality (HP:0001969)1.04452046
194Preaxial hand polydactyly (HP:0001177)1.04402540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK399.96861378
2OXSR16.84105977
3MST44.54272417
4AKT34.50301433
5LMTK23.72787092
6TAOK32.90800899
7SMG12.82136093
8LATS12.57790176
9FRK2.18484156
10SCYL22.08913067
11STK242.08317817
12PIK3CG2.02342497
13MAPK1510.9744404
14NME11.93023330
15TNK21.87658073
16SIK11.81686369
17MAP3K31.79912271
18ERN11.72518042
19TTK1.69088455
20FER1.68475947
21CSK1.55201818
22EEF2K1.34188175
23PHKG21.33923884
24PHKG11.33923884
25TTN1.29385468
26MST1R1.27681980
27EPHA31.24265171
28MAP3K121.21791885
29BCKDK1.16547086
30BCR1.15864249
31PTK2B1.13018374
32STK101.11233136
33LRRK21.10991112
34MAP3K21.09744389
35TESK21.08616891
36MARK21.08129388
37PBK1.00463755
38PIK3CA0.98751780
39TBK10.94816972
40ERBB30.92426320
41EPHA20.91009195
42PTK60.85192520
43INSRR0.84197960
44CAMKK10.80987636
45MYLK0.66212159
46TESK10.64996870
47NUAK10.62663075
48TLK10.61198096
49PNCK0.60773082
50RPS6KB20.58982947
51ROCK20.56268006
52STK30.55700772
53DMPK0.55443420
54TRIB30.54227784
55CAMK2G0.51091734
56PRKCD0.51031450
57STK160.50516070
58GRK60.50501243
59PRKAA20.50280278
60NLK0.47067399
61BRSK20.46902696
62PRKCI0.45198016
63MAPKAPK30.44758034
64PDPK10.44541293
65HIPK20.44192599
66ZAP700.42907968
67TAOK10.42824635
68TRPM70.40479450
69MAP3K40.40463018
70FGFR30.39036055
71PAK40.38778943
72JAK10.38759752
73SGK10.38280656
74LATS20.37737832
75ILK0.36790051
76RIPK10.35886703
77RET0.35722177
78ERBB20.34961855
79WNK40.34695954
80JAK20.34010441
81PDK20.34007365
82IRAK10.32642035
83MAP3K70.32083594
84MET0.31871619
85AURKA0.31786722
86ROCK10.31148199
87PKN20.30426115
88WNK10.30154519
89PKN10.30109108
90PRKCQ0.29135128
91OBSCN0.28723464
92DYRK1B0.28493606
93DAPK20.28388327
94PDGFRA0.28368516
95PAK10.27031369
96MAP3K80.26023101
97MAP2K40.25097710
98RPS6KA20.24326524
99ICK0.23614360
100PAK20.23230458
101FGFR20.23214075
102BMPR20.23105483
103MTOR0.22622531
104SGK2230.22081560
105SGK4940.22081560
106MAPKAPK50.21600108
107SGK30.21294929
108PRKCA0.20699626
109STK380.20513485
110PRKD10.19974273
111ERBB40.19527655
112MAP3K60.19519258
113STK38L0.19407820
114ABL10.19085396
115CDK60.18922964
116PRKACA0.18815428
117EGFR0.18536274
118DDR20.18517276
119ADRBK10.18256951
120CAMKK20.17639399
121EPHB10.16464024
122KSR20.16131681
123LIMK10.14957049
124PIM20.14394405
125CSF1R0.14285207
126PRKD30.14238332
127PTK20.14178605
128RPS6KB10.14057729
129PRKAA10.13946929
130NTRK30.13513684
131IGF1R0.12877315
132CDK50.12161223
133RIPK40.12029174
134NTRK10.11854808
135FYN0.11062298
136MELK0.10799059
137SRC0.10205626
138TYK20.09214636
139MAP3K90.08966480
140CDC42BPA0.08886845
141PRKCE0.08115425
142JAK30.07627937
143NEK60.07199886
144MAP2K20.07146012
145PRKACB0.06981024
146PDK10.05756332
147RPS6KA30.05260774
148AKT20.04849233
149PAK30.04401640
150MATK0.03976902
151CAMK10.03778980

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006017.05544942
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.66152222
3Phenylalanine metabolism_Homo sapiens_hsa003605.60058386
4Sulfur metabolism_Homo sapiens_hsa009205.12319224
5Histidine metabolism_Homo sapiens_hsa003405.04653812
6Chemical carcinogenesis_Homo sapiens_hsa052044.61215766
7Tyrosine metabolism_Homo sapiens_hsa003504.60817121
8Renin-angiotensin system_Homo sapiens_hsa046144.35749884
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.32938042
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.05501849
11Glutathione metabolism_Homo sapiens_hsa004802.92032874
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.87039227
13Retinol metabolism_Homo sapiens_hsa008302.68181157
14Vibrio cholerae infection_Homo sapiens_hsa051102.37567554
15Other glycan degradation_Homo sapiens_hsa005112.30276466
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.04207453
17Nitrogen metabolism_Homo sapiens_hsa009101.95254760
18Thyroid hormone synthesis_Homo sapiens_hsa049181.82178727
19Caffeine metabolism_Homo sapiens_hsa002321.73557710
20Protein export_Homo sapiens_hsa030601.72775291
21Huntingtons disease_Homo sapiens_hsa050161.70300217
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67736059
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66297171
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63181310
25N-Glycan biosynthesis_Homo sapiens_hsa005101.62847530
26Salivary secretion_Homo sapiens_hsa049701.62681792
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.59020436
28Propanoate metabolism_Homo sapiens_hsa006401.48735957
29Thyroid cancer_Homo sapiens_hsa052161.44422175
30Selenocompound metabolism_Homo sapiens_hsa004501.32872468
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31877362
32Tight junction_Homo sapiens_hsa045301.29932642
33Adherens junction_Homo sapiens_hsa045201.26217021
34Linoleic acid metabolism_Homo sapiens_hsa005911.25589545
35Fatty acid degradation_Homo sapiens_hsa000711.25553870
36Arachidonic acid metabolism_Homo sapiens_hsa005901.15439153
37Prostate cancer_Homo sapiens_hsa052151.09131304
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06198758
39Hippo signaling pathway_Homo sapiens_hsa043901.04490484
40Peroxisome_Homo sapiens_hsa041461.04361428
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01096467
42Mineral absorption_Homo sapiens_hsa049780.99913480
43Insulin resistance_Homo sapiens_hsa049310.97751475
44Lysosome_Homo sapiens_hsa041420.96685432
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.94215205
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93160305
47Pancreatic secretion_Homo sapiens_hsa049720.90953646
48Inositol phosphate metabolism_Homo sapiens_hsa005620.89808374
49Protein digestion and absorption_Homo sapiens_hsa049740.88604994
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.81210666
51Arginine biosynthesis_Homo sapiens_hsa002200.80942245
52Endometrial cancer_Homo sapiens_hsa052130.80515266
53TGF-beta signaling pathway_Homo sapiens_hsa043500.78766875
54Arginine and proline metabolism_Homo sapiens_hsa003300.78430450
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.78130139
56ABC transporters_Homo sapiens_hsa020100.77203197
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76895607
58Circadian rhythm_Homo sapiens_hsa047100.76241469
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72979850
60mTOR signaling pathway_Homo sapiens_hsa041500.67680303
61Bladder cancer_Homo sapiens_hsa052190.66312300
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.64108315
63Sphingolipid metabolism_Homo sapiens_hsa006000.62852420
64Proteoglycans in cancer_Homo sapiens_hsa052050.62638094
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61353379
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61116231
67Fatty acid metabolism_Homo sapiens_hsa012120.60266843
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59840772
69Focal adhesion_Homo sapiens_hsa045100.59202277
70Collecting duct acid secretion_Homo sapiens_hsa049660.59004180
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56271002
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55916414
73Gastric acid secretion_Homo sapiens_hsa049710.55639294
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53154055
75Starch and sucrose metabolism_Homo sapiens_hsa005000.53046320
76Amoebiasis_Homo sapiens_hsa051460.52825737
77Hepatitis C_Homo sapiens_hsa051600.52096558
78Estrogen signaling pathway_Homo sapiens_hsa049150.51202260
79ErbB signaling pathway_Homo sapiens_hsa040120.50316045
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49752870
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.49670098
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49370718
83Insulin signaling pathway_Homo sapiens_hsa049100.49362097
84Notch signaling pathway_Homo sapiens_hsa043300.47511783
85Lysine degradation_Homo sapiens_hsa003100.47268329
86beta-Alanine metabolism_Homo sapiens_hsa004100.47073519
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.45874550
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44744528
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39646947
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.39386810
91Bile secretion_Homo sapiens_hsa049760.38540068
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38407775
93ECM-receptor interaction_Homo sapiens_hsa045120.36814499
94Choline metabolism in cancer_Homo sapiens_hsa052310.36728129
95Synaptic vesicle cycle_Homo sapiens_hsa047210.36547963
96Taste transduction_Homo sapiens_hsa047420.35292604
97AMPK signaling pathway_Homo sapiens_hsa041520.34152088
98Fatty acid biosynthesis_Homo sapiens_hsa000610.34078212
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33950051
100PPAR signaling pathway_Homo sapiens_hsa033200.33283140
101Type II diabetes mellitus_Homo sapiens_hsa049300.33114783
102Fructose and mannose metabolism_Homo sapiens_hsa000510.32764877
103Endocytosis_Homo sapiens_hsa041440.32659457
104Pyruvate metabolism_Homo sapiens_hsa006200.32554845
105Pancreatic cancer_Homo sapiens_hsa052120.32308781
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31693909
107Metabolic pathways_Homo sapiens_hsa011000.30987950
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.30876662
109Cocaine addiction_Homo sapiens_hsa050300.30295481
110Glucagon signaling pathway_Homo sapiens_hsa049220.30034143
111Glioma_Homo sapiens_hsa052140.29988592
112Insulin secretion_Homo sapiens_hsa049110.29624577
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28187795
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28153081
115Non-small cell lung cancer_Homo sapiens_hsa052230.27254357
116Hematopoietic cell lineage_Homo sapiens_hsa046400.26342543
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23886504
118Renin secretion_Homo sapiens_hsa049240.23860483
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.23271465
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23236055
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.23100624
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22845661
123Vitamin digestion and absorption_Homo sapiens_hsa049770.22845056
124Complement and coagulation cascades_Homo sapiens_hsa046100.22728396
125Platelet activation_Homo sapiens_hsa046110.22142756
126Tryptophan metabolism_Homo sapiens_hsa003800.22137639
127Melanogenesis_Homo sapiens_hsa049160.21997106
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21967799
129Melanoma_Homo sapiens_hsa052180.20597829
130Hedgehog signaling pathway_Homo sapiens_hsa043400.20051462
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19946597
132Small cell lung cancer_Homo sapiens_hsa052220.19401680
133Olfactory transduction_Homo sapiens_hsa047400.18173383
134Ovarian steroidogenesis_Homo sapiens_hsa049130.17699540
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17159569
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15220633
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15002889
138cAMP signaling pathway_Homo sapiens_hsa040240.14650268
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.13548679
140Amphetamine addiction_Homo sapiens_hsa050310.12234971
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12033004
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11096469
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10477178
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10435402
145Type I diabetes mellitus_Homo sapiens_hsa049400.10132768
146Dilated cardiomyopathy_Homo sapiens_hsa054140.08662920
147Basal cell carcinoma_Homo sapiens_hsa052170.06336331
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.06235883
149Phagosome_Homo sapiens_hsa041450.05346157
150Steroid biosynthesis_Homo sapiens_hsa001000.03014991
151Glycerolipid metabolism_Homo sapiens_hsa005610.01052112

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