MSMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.89866594
2central nervous system myelination (GO:0022010)9.89866594
3fatty acid elongation (GO:0030497)9.08629936
4* cholesterol biosynthetic process (GO:0006695)7.50342119
5* sterol biosynthetic process (GO:0016126)6.56970666
6long-chain fatty acid biosynthetic process (GO:0042759)6.17286212
7isoprenoid biosynthetic process (GO:0008299)5.86286746
8myelination (GO:0042552)5.67776363
9axon ensheathment (GO:0008366)5.65855072
10ensheathment of neurons (GO:0007272)5.65855072
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.34859067
12long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.76748886
13fatty-acyl-CoA biosynthetic process (GO:0046949)4.72163046
14pyrimidine nucleobase catabolic process (GO:0006208)4.60626838
15fatty-acyl-CoA metabolic process (GO:0035337)4.22781638
16L-amino acid import (GO:0043092)4.22098106
17response to methylmercury (GO:0051597)4.22039943
18very long-chain fatty acid metabolic process (GO:0000038)4.14633388
19negative regulation of neurotransmitter transport (GO:0051589)4.09551944
20myelin maintenance (GO:0043217)4.08992077
21glycerophospholipid catabolic process (GO:0046475)4.07876711
22oligodendrocyte differentiation (GO:0048709)4.01957613
23response to lipoprotein particle (GO:0055094)3.99042687
24regulation of collateral sprouting (GO:0048670)3.97989552
25acyl-CoA biosynthetic process (GO:0071616)3.85008375
26thioester biosynthetic process (GO:0035384)3.85008375
27negative regulation of neurotransmitter secretion (GO:0046929)3.76770058
28nucleobase catabolic process (GO:0046113)3.74787077
29amyloid precursor protein metabolic process (GO:0042982)3.73289570
30nucleotide transmembrane transport (GO:1901679)3.70785745
31negative regulation of protein localization to cell surface (GO:2000009)3.69870635
32amino acid import (GO:0043090)3.56023831
33response to redox state (GO:0051775)3.52657131
34substantia nigra development (GO:0021762)3.52089774
35response to follicle-stimulating hormone (GO:0032354)3.48469189
36regulation of lipoprotein metabolic process (GO:0050746)3.45736313
37establishment of mitochondrion localization (GO:0051654)3.42999193
38limb bud formation (GO:0060174)3.36400349
39photoreceptor cell differentiation (GO:0046530)3.33728039
40eye photoreceptor cell differentiation (GO:0001754)3.33728039
41presynaptic membrane organization (GO:0097090)3.32646994
42import into cell (GO:0098657)3.28698366
43cellular response to cholesterol (GO:0071397)3.27612921
44positive regulation of cellular amine metabolic process (GO:0033240)3.25658063
45presynaptic membrane assembly (GO:0097105)3.22954364
46apical protein localization (GO:0045176)3.20009218
47asymmetric protein localization (GO:0008105)3.19901907
48* alcohol biosynthetic process (GO:0046165)3.19434838
49myelination in peripheral nervous system (GO:0022011)3.19008352
50peripheral nervous system axon ensheathment (GO:0032292)3.19008352
51positive regulation of oligodendrocyte differentiation (GO:0048714)3.18250805
52* cholesterol metabolic process (GO:0008203)3.13366658
53water-soluble vitamin biosynthetic process (GO:0042364)3.12711996
54cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.09186834
55L-phenylalanine catabolic process (GO:0006559)3.08779071
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08779071
57* steroid biosynthetic process (GO:0006694)3.07090859
58astrocyte development (GO:0014002)3.05796257
59glyoxylate metabolic process (GO:0046487)3.05390350
60intraciliary transport (GO:0042073)3.01587531
61protein neddylation (GO:0045116)2.95992906
62amyloid precursor protein catabolic process (GO:0042987)2.95991364
63creatine metabolic process (GO:0006600)2.95339092
64neurotransmitter uptake (GO:0001504)2.93176460
65nucleotide transport (GO:0006862)2.92337233
66thioester metabolic process (GO:0035383)2.92269854
67acyl-CoA metabolic process (GO:0006637)2.92269854
68cullin deneddylation (GO:0010388)2.91556139
69neuron cell-cell adhesion (GO:0007158)2.89625731
70estrogen biosynthetic process (GO:0006703)2.89568732
71response to phenylpropanoid (GO:0080184)2.88322738
72heme transport (GO:0015886)2.87853975
73* sterol metabolic process (GO:0016125)2.87809279
74cerebral cortex radially oriented cell migration (GO:0021799)2.87158261
75C4-dicarboxylate transport (GO:0015740)2.84360687
76neuron remodeling (GO:0016322)2.81664468
77retinal ganglion cell axon guidance (GO:0031290)2.78504808
78serine family amino acid catabolic process (GO:0009071)2.76446832
79negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.76333887
80axon development (GO:0061564)2.74823867
81GPI anchor metabolic process (GO:0006505)2.72784215
82iron coordination entity transport (GO:1901678)2.72656510
83protein palmitoylation (GO:0018345)2.70924011
84L-serine metabolic process (GO:0006563)2.70526694
85postsynaptic membrane organization (GO:0001941)2.69974637
86magnesium ion transport (GO:0015693)2.69877885
87positive regulation of mitochondrial fission (GO:0090141)2.68522540
88calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67985634
89nonmotile primary cilium assembly (GO:0035058)2.67982157
90DNA double-strand break processing (GO:0000729)2.65106356
91transmission of nerve impulse (GO:0019226)2.65087828
92ubiquinone metabolic process (GO:0006743)2.64716691
93terpenoid biosynthetic process (GO:0016114)2.64457443
94cellular response to sterol (GO:0036315)2.64051846
95GPI anchor biosynthetic process (GO:0006506)2.63670498
96dopamine biosynthetic process (GO:0042416)2.61578955
97coenzyme catabolic process (GO:0009109)2.60724597
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59761878
99cilium morphogenesis (GO:0060271)2.58538827
100olfactory bulb development (GO:0021772)2.58188918
101virion attachment to host cell (GO:0019062)2.56505347
102adhesion of symbiont to host cell (GO:0044650)2.56505347
103triglyceride biosynthetic process (GO:0019432)2.56319668
104pyrimidine-containing compound transmembrane transport (GO:0072531)2.56229420
105protein deneddylation (GO:0000338)2.55553479
106cysteine metabolic process (GO:0006534)2.54459078
107purine ribonucleotide transport (GO:0015868)2.51415186
108epithelial cilium movement (GO:0003351)2.49326584
109auditory behavior (GO:0031223)2.48872982
110vocalization behavior (GO:0071625)2.48344077
111peripheral nervous system development (GO:0007422)2.48027226
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.48025851
113L-phenylalanine metabolic process (GO:0006558)2.48025851
114regulation of development, heterochronic (GO:0040034)2.47842421
115neutral lipid biosynthetic process (GO:0046460)2.47045654
116acylglycerol biosynthetic process (GO:0046463)2.47045654
117* organic hydroxy compound biosynthetic process (GO:1901617)2.45210809
118glycosylceramide metabolic process (GO:0006677)2.43051461
119preassembly of GPI anchor in ER membrane (GO:0016254)2.41639914
120regulation of timing of cell differentiation (GO:0048505)2.41237841
121neural nucleus development (GO:0048857)2.40263306
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40078692
123negative regulation of astrocyte differentiation (GO:0048712)2.39469031
124intestinal cholesterol absorption (GO:0030299)2.38948655
125platelet dense granule organization (GO:0060155)2.38127525
126cellular response to gonadotropin stimulus (GO:0071371)2.38027919
127sphingomyelin metabolic process (GO:0006684)2.36665840
128protein localization to cilium (GO:0061512)2.36162554
129glial cell differentiation (GO:0010001)2.35021773
130L-serine transport (GO:0015825)2.34034871
131cranial nerve development (GO:0021545)2.33998149
132hindbrain development (GO:0030902)2.33867276
133bile acid biosynthetic process (GO:0006699)2.32835523
134regulation of cilium movement (GO:0003352)2.32678214
135mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.31376790
136positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.31376790
137response to pheromone (GO:0019236)2.31170313
138serine family amino acid metabolic process (GO:0009069)2.30946683
139lipid particle organization (GO:0034389)2.30667035
140regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.30174206
141vitamin biosynthetic process (GO:0009110)2.28015959
142isoprenoid metabolic process (GO:0006720)2.27670834
143amino acid salvage (GO:0043102)2.26657610
144L-methionine salvage (GO:0071267)2.26657610
145L-methionine biosynthetic process (GO:0071265)2.26657610
146mechanosensory behavior (GO:0007638)2.25034857
147peptidyl-cysteine modification (GO:0018198)2.24568521
148negative regulation of axon guidance (GO:1902668)2.24251968
149vascular smooth muscle contraction (GO:0014829)2.23370380
150axonal fasciculation (GO:0007413)2.22414849
151sequestering of actin monomers (GO:0042989)2.20148712
152dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.19302169
153branched-chain amino acid catabolic process (GO:0009083)2.17575994
154DNA damage response, detection of DNA damage (GO:0042769)2.16924326
155cilium assembly (GO:0042384)2.16636357
156dorsal/ventral axis specification (GO:0009950)2.15883966
157cilium organization (GO:0044782)2.15208357
158aldehyde catabolic process (GO:0046185)2.14938811
159exogenous drug catabolic process (GO:0042738)2.14599118
160response to auditory stimulus (GO:0010996)2.14039487
161serine family amino acid biosynthetic process (GO:0009070)2.12154420
162alpha-linolenic acid metabolic process (GO:0036109)2.08529555
163behavioral response to nicotine (GO:0035095)2.07513649
164L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.06451241
165neuron recognition (GO:0008038)2.05650993
166neurotransmitter-gated ion channel clustering (GO:0072578)2.05073590
167dendritic spine morphogenesis (GO:0060997)2.03445997
168negative chemotaxis (GO:0050919)2.02993382
169S-adenosylmethionine metabolic process (GO:0046500)2.02729171
170anterior/posterior axis specification (GO:0009948)2.01732677
171mannosylation (GO:0097502)2.01475579
172quinone metabolic process (GO:1901661)2.01351687
173somite development (GO:0061053)2.00362276
174cilium movement (GO:0003341)2.00339246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.10517212
2ZNF274_21170338_ChIP-Seq_K562_Hela2.77240565
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61662472
4IGF1R_20145208_ChIP-Seq_DFB_Human2.59017719
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58440929
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.54590168
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.46378696
8TAF15_26573619_Chip-Seq_HEK293_Human2.28058638
9AR_21572438_ChIP-Seq_LNCaP_Human2.21565660
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21269511
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15576895
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13675583
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10725793
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03807380
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.03536680
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98172809
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96852253
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91356612
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91325866
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.86957915
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84488324
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80943868
23ELK1_19687146_ChIP-ChIP_HELA_Human1.80891002
24ER_23166858_ChIP-Seq_MCF-7_Human1.78806922
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.78073415
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77919838
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76761759
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76296644
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76068530
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76061458
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70328663
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70125806
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.69110675
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.67629690
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65216310
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64740244
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62902710
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60094121
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60094121
40P300_19829295_ChIP-Seq_ESCs_Human1.59650179
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57112432
42EZH2_22144423_ChIP-Seq_EOC_Human1.56356349
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.54427208
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53303321
45HTT_18923047_ChIP-ChIP_STHdh_Human1.52039821
46FUS_26573619_Chip-Seq_HEK293_Human1.51961403
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51689633
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51689633
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49715363
50VDR_22108803_ChIP-Seq_LS180_Human1.45830226
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.45262613
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.42655947
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41882032
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41748245
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39586940
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.33545180
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32929340
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.32871934
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31662870
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29526661
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29378051
62AR_25329375_ChIP-Seq_VCAP_Human1.29343740
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27905824
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.26653025
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26560563
66CBP_20019798_ChIP-Seq_JUKART_Human1.26560563
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25835153
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25639801
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24844621
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.23455035
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23167594
72IRF1_19129219_ChIP-ChIP_H3396_Human1.22776699
73RNF2_27304074_Chip-Seq_NSC_Mouse1.22396285
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.21972071
75MYC_18940864_ChIP-ChIP_HL60_Human1.21969758
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21888097
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19503706
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18981212
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18291496
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18265139
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18246446
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18049160
83TCF4_22108803_ChIP-Seq_LS180_Human1.17895512
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16984177
85P300_18555785_Chip-Seq_ESCs_Mouse1.14662958
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.14180125
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13105061
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13091395
89TP53_18474530_ChIP-ChIP_U2OS_Human1.12774484
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11501357
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11015902
92BCAT_22108803_ChIP-Seq_LS180_Human1.10675409
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10425572
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.10059820
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10029260
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08528642
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07624449
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.07119079
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05751301
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.05542801
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05397165
102SMAD4_21799915_ChIP-Seq_A2780_Human1.05008597
103P53_22387025_ChIP-Seq_ESCs_Mouse1.04754840
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04704632
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04423806
106STAT3_23295773_ChIP-Seq_U87_Human1.03613771
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03548453
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03461366
109TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03153894
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02799031
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02489617
112LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02478560
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.02070141
114SOX2_19829295_ChIP-Seq_ESCs_Human1.01310636
115NANOG_19829295_ChIP-Seq_ESCs_Human1.01310636
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01241784
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.01042834
118TP53_16413492_ChIP-PET_HCT116_Human1.00590448
119SOX9_26525672_Chip-Seq_HEART_Mouse1.00480686
120KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00080536
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.99745804
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98574324
123TCF4_23295773_ChIP-Seq_U87_Human0.98310002
124SOX2_18555785_Chip-Seq_ESCs_Mouse0.96826897
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96580682
126SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96491753
127CRX_20693478_ChIP-Seq_RETINA_Mouse0.96431579
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96220982
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.95564065
130RUNX2_22187159_ChIP-Seq_PCA_Human0.95476881
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95317774
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95293504
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94872201
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94861432
135EWS_26573619_Chip-Seq_HEK293_Human0.93571695
136JUN_21703547_ChIP-Seq_K562_Human0.92742557
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92591892
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.92444268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.30300367
2MP0003690_abnormal_glial_cell3.22569692
3MP0003880_abnormal_central_pattern3.05091456
4MP0003122_maternal_imprinting3.01988704
5MP0003136_yellow_coat_color2.94939899
6MP0001529_abnormal_vocalization2.87719260
7MP0003329_amyloid_beta_deposits2.86848968
8MP0003890_abnormal_embryonic-extraembry2.85735516
9MP0001905_abnormal_dopamine_level2.76812393
10MP0003806_abnormal_nucleotide_metabolis2.74364478
11MP0003950_abnormal_plasma_membrane2.64718428
12MP0004885_abnormal_endolymph2.60506838
13MP0005171_absent_coat_pigmentation2.55045607
14MP0004270_analgesia2.47070738
15MP0001984_abnormal_olfaction2.22558038
16MP0004742_abnormal_vestibular_system2.12086408
17MP0004142_abnormal_muscle_tone2.10507058
18MP0001486_abnormal_startle_reflex2.08072654
19MP0003634_abnormal_glial_cell2.06135717
20MP0002139_abnormal_hepatobiliary_system2.04022015
21MP0000778_abnormal_nervous_system1.95471507
22MP0003941_abnormal_skin_development1.95114973
23MP0004133_heterotaxia1.91643135
24MP0001485_abnormal_pinna_reflex1.89395259
25MP0003121_genomic_imprinting1.89318703
26MP0004134_abnormal_chest_morphology1.87150124
27MP0005187_abnormal_penis_morphology1.85398256
28MP0000566_synostosis1.84641610
29MP0002272_abnormal_nervous_system1.80986643
30MP0002102_abnormal_ear_morphology1.78391606
31MP0004381_abnormal_hair_follicle1.73592500
32MP0003632_abnormal_nervous_system1.73202617
33MP0005409_darkened_coat_color1.72766190
34MP0006054_spinal_hemorrhage1.71862938
35MP0002064_seizures1.68003082
36MP0005499_abnormal_olfactory_system1.65515007
37MP0005394_taste/olfaction_phenotype1.65515007
38MP0000604_amyloidosis1.62718207
39MP0005451_abnormal_body_composition1.62363145
40MP0003011_delayed_dark_adaptation1.62334685
41MP0003195_calcinosis1.60598283
42MP0008789_abnormal_olfactory_epithelium1.58456960
43MP0000462_abnormal_digestive_system1.56100493
44MP0006072_abnormal_retinal_apoptosis1.51570533
45MP0000372_irregular_coat_pigmentation1.51059083
46MP0005423_abnormal_somatic_nervous1.49834181
47MP0001293_anophthalmia1.49229100
48MP0000647_abnormal_sebaceous_gland1.48545928
49MP0005551_abnormal_eye_electrophysiolog1.48279472
50MP0002229_neurodegeneration1.45391885
51MP0001440_abnormal_grooming_behavior1.44707401
52MP0005248_abnormal_Harderian_gland1.43898782
53MP0002233_abnormal_nose_morphology1.40594159
54MP0003119_abnormal_digestive_system1.39720467
55MP0002734_abnormal_mechanical_nocicepti1.39602579
56MP0009745_abnormal_behavioral_response1.36157669
57MP0002234_abnormal_pharynx_morphology1.35869772
58MP0005410_abnormal_fertilization1.33577015
59MP0002572_abnormal_emotion/affect_behav1.30102492
60MP0002638_abnormal_pupillary_reflex1.29145258
61MP0005365_abnormal_bile_salt1.28268148
62MP0003631_nervous_system_phenotype1.26756832
63MP0009840_abnormal_foam_cell1.25631285
64MP0009046_muscle_twitch1.24970561
65MP0002282_abnormal_trachea_morphology1.24414211
66MP0006292_abnormal_olfactory_placode1.23303535
67MP0002751_abnormal_autonomic_nervous1.22318678
68MP0001963_abnormal_hearing_physiology1.20663130
69MP0001661_extended_life_span1.20313589
70MP0003755_abnormal_palate_morphology1.19783999
71MP0005083_abnormal_biliary_tract1.19781420
72MP0006276_abnormal_autonomic_nervous1.19338641
73MP0010678_abnormal_skin_adnexa1.18480668
74MP0000383_abnormal_hair_follicle1.15343567
75MP0003635_abnormal_synaptic_transmissio1.13587871
76MP0001286_abnormal_eye_development1.12347937
77MP0005084_abnormal_gallbladder_morpholo1.11201097
78MP0004043_abnormal_pH_regulation1.11188133
79MP0010329_abnormal_lipoprotein_level1.10900364
80MP0003315_abnormal_perineum_morphology1.09761056
81MP0008875_abnormal_xenobiotic_pharmacok1.09577344
82MP0001299_abnormal_eye_distance/1.09171837
83MP0002653_abnormal_ependyma_morphology1.08933061
84MP0005386_behavior/neurological_phenoty1.08742008
85MP0004924_abnormal_behavior1.08742008
86MP0000955_abnormal_spinal_cord1.07339357
87MP0002295_abnormal_pulmonary_circulatio1.07011053
88MP0000762_abnormal_tongue_morphology1.06640093
89MP0002882_abnormal_neuron_morphology1.06443540
90MP0002733_abnormal_thermal_nociception1.06076476
91MP0009384_cardiac_valve_regurgitation1.06034362
92MP0001970_abnormal_pain_threshold1.03929864
93MP0005408_hypopigmentation1.03337311
94MP0000516_abnormal_urinary_system1.02988666
95MP0005367_renal/urinary_system_phenotyp1.02988666
96MP0003937_abnormal_limbs/digits/tail_de1.02901532
97MP0009697_abnormal_copulation1.02782123
98MP0005391_vision/eye_phenotype1.02651222
99MP0003633_abnormal_nervous_system1.02303954
100MP0000639_abnormal_adrenal_gland1.01113598
101MP0002697_abnormal_eye_size1.00879166
102MP0005646_abnormal_pituitary_gland0.99522419
103MP0003567_abnormal_fetal_cardiomyocyte0.99047367
104MP0005253_abnormal_eye_physiology0.98949376
105MP0002938_white_spotting0.98748717
106MP0002067_abnormal_sensory_capabilities0.98711737
107MP0005195_abnormal_posterior_eye0.98637589
108MP0002752_abnormal_somatic_nervous0.98585275
109MP0000631_abnormal_neuroendocrine_gland0.97901963
110MP0004272_abnormal_basement_membrane0.97271984
111MP0002063_abnormal_learning/memory/cond0.95808079
112MP0002066_abnormal_motor_capabilities/c0.95755156
113MP0005379_endocrine/exocrine_gland_phen0.95488964
114MP0002090_abnormal_vision0.95453547
115MP0009250_abnormal_appendicular_skeleto0.94995635
116MP0002736_abnormal_nociception_after0.94980086
117MP0001177_atelectasis0.93538701
118MP0008058_abnormal_DNA_repair0.93301322
119MP0008932_abnormal_embryonic_tissue0.93012913
120MP0005332_abnormal_amino_acid0.92959547
121MP0000026_abnormal_inner_ear0.92118031
122MP0001968_abnormal_touch/_nociception0.91009678
123MP0008877_abnormal_DNA_methylation0.90938827
124MP0008260_abnormal_autophagy0.89650315
125MP0000049_abnormal_middle_ear0.88806360
126MP0003861_abnormal_nervous_system0.88606568
127MP0002184_abnormal_innervation0.87197912
128MP0005085_abnormal_gallbladder_physiolo0.86717048
129MP0001324_abnormal_eye_pigmentation0.85912731
130MP0001346_abnormal_lacrimal_gland0.85510465
131MP0003252_abnormal_bile_duct0.85489433
132MP0003938_abnormal_ear_development0.83809781
133MP0001502_abnormal_circadian_rhythm0.83336048
134MP0000427_abnormal_hair_cycle0.83014736
135MP0004859_abnormal_synaptic_plasticity0.82038060
136MP0002735_abnormal_chemical_nociception0.81776632
137MP0004147_increased_porphyrin_level0.81198794
138MP0005058_abnormal_lysosome_morphology0.80581595
139MP0005377_hearing/vestibular/ear_phenot0.80574278
140MP0003878_abnormal_ear_physiology0.80574278
141MP0001501_abnormal_sleep_pattern0.80323414
142MP0001666_abnormal_nutrient_absorption0.80104986
143MP0003787_abnormal_imprinting0.79253244
144MP0002909_abnormal_adrenal_gland0.79193238
145MP0000579_abnormal_nail_morphology0.78878915
146MP0005360_urolithiasis0.78791397
147MP0002152_abnormal_brain_morphology0.78760204
148MP0002111_abnormal_tail_morphology0.78319611
149MP0002822_catalepsy0.77873035
150MP0009780_abnormal_chondrocyte_physiolo0.77610380
151MP0009703_decreased_birth_body0.77568368
152MP0001188_hyperpigmentation0.77422555
153MP0002118_abnormal_lipid_homeostasis0.76982664
154MP0002557_abnormal_social/conspecific_i0.76934686
155MP0003718_maternal_effect0.75149178
156MP0003868_abnormal_feces_composition0.73522880
157MP0001986_abnormal_taste_sensitivity0.72577792

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.79320211
2Parakeratosis (HP:0001036)5.72161309
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.12025952
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.12025952
5Cerebral inclusion bodies (HP:0100314)4.18040674
6Hypoplastic pelvis (HP:0008839)4.15480505
7Abnormality of glycolysis (HP:0004366)3.92427197
8Increased serum pyruvate (HP:0003542)3.92427197
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.86543113
10Abnormality of the corticospinal tract (HP:0002492)3.82067884
11Congenital ichthyosiform erythroderma (HP:0007431)3.40486706
12Sensory axonal neuropathy (HP:0003390)3.34352233
13Hyperglycinemia (HP:0002154)3.27735875
14Aplasia involving bones of the extremities (HP:0009825)3.19434961
15Aplasia involving bones of the upper limbs (HP:0009823)3.19434961
16Aplasia of the phalanges of the hand (HP:0009802)3.19434961
17Epidermoid cyst (HP:0200040)3.09439510
18Peripheral hypomyelination (HP:0007182)3.08995430
19True hermaphroditism (HP:0010459)3.01207866
20Abnormality of the labia minora (HP:0012880)2.89420752
21Pancreatic fibrosis (HP:0100732)2.78075505
22Bifid tongue (HP:0010297)2.75657532
23Medial flaring of the eyebrow (HP:0010747)2.73066862
24Gait imbalance (HP:0002141)2.72227191
25Epiphyseal dysplasia (HP:0002656)2.70786564
26Polyphagia (HP:0002591)2.68170418
27Genital tract atresia (HP:0001827)2.63740816
28Termporal pattern (HP:0011008)2.63694692
29Insidious onset (HP:0003587)2.63694692
30Congenital primary aphakia (HP:0007707)2.62337055
31Intrahepatic cholestasis (HP:0001406)2.62279545
32Leukodystrophy (HP:0002415)2.61154391
33Supranuclear gaze palsy (HP:0000605)2.59620836
34Vaginal atresia (HP:0000148)2.57001268
35Irregular epiphyses (HP:0010582)2.55942203
36Abnormality of the phalanges of the 2nd finger (HP:0009541)2.54744183
37Adrenal hypoplasia (HP:0000835)2.48192593
38Hepatoblastoma (HP:0002884)2.47879121
39Pancreatic cysts (HP:0001737)2.46915038
40Onion bulb formation (HP:0003383)2.46496207
41Abnormality of serine family amino acid metabolism (HP:0010894)2.46014947
42Abnormality of glycine metabolism (HP:0010895)2.46014947
43Molar tooth sign on MRI (HP:0002419)2.45378685
44Abnormality of midbrain morphology (HP:0002418)2.45378685
45Cortical dysplasia (HP:0002539)2.44960718
46Anomalous pulmonary venous return (HP:0010772)2.44379352
47Nephrogenic diabetes insipidus (HP:0009806)2.43974470
48Small epiphyses (HP:0010585)2.42736161
49Scrotal hypoplasia (HP:0000046)2.41734582
50Myelomeningocele (HP:0002475)2.41643477
51Clumsiness (HP:0002312)2.41593652
52Spastic gait (HP:0002064)2.41142026
53Renal Fanconi syndrome (HP:0001994)2.39814078
54Retinal dysplasia (HP:0007973)2.39120689
55Autoamputation (HP:0001218)2.37512490
56Abnormality of the axillary hair (HP:0100134)2.37073323
57Abnormality of secondary sexual hair (HP:0009888)2.37073323
58Spastic paraparesis (HP:0002313)2.35335267
59Alacrima (HP:0000522)2.33708097
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.33237887
61Hypoplastic left heart (HP:0004383)2.31463889
62Postaxial foot polydactyly (HP:0001830)2.29497528
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.28489814
64Short tibia (HP:0005736)2.27710030
65Abnormal lung lobation (HP:0002101)2.27604202
66Intestinal atresia (HP:0011100)2.27272586
67Mixed hearing impairment (HP:0000410)2.26621274
68Postaxial hand polydactyly (HP:0001162)2.26349189
69Abnormality of the middle phalanges of the toes (HP:0010183)2.25964624
70Absent septum pellucidum (HP:0001331)2.25820680
71Methylmalonic acidemia (HP:0002912)2.25289114
72Megalencephaly (HP:0001355)2.25185220
73Abnormal auditory evoked potentials (HP:0006958)2.23765928
74Akinesia (HP:0002304)2.20871318
75Labial hypoplasia (HP:0000066)2.19674847
76Chronic hepatic failure (HP:0100626)2.19295953
77Hypophosphatemic rickets (HP:0004912)2.19197358
78Acute necrotizing encephalopathy (HP:0006965)2.17612050
79Hepatosplenomegaly (HP:0001433)2.17093364
80Humeroradial synostosis (HP:0003041)2.14986757
81Synostosis involving the elbow (HP:0003938)2.14986757
82Coronal craniosynostosis (HP:0004440)2.14265328
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14177073
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13390050
85Infantile muscular hypotonia (HP:0008947)2.11139938
86Abnormality of the pulmonary veins (HP:0011718)2.09587790
87Intention tremor (HP:0002080)2.08694492
88Hyperglycinuria (HP:0003108)2.08455727
89Broad alveolar ridges (HP:0000187)2.08086602
90Barrel-shaped chest (HP:0001552)2.08001656
91Cupped ear (HP:0000378)2.07102816
92Abnormality of serum amino acid levels (HP:0003112)2.06609841
93Aplasia of the musculature (HP:0100854)2.06075825
94Drooling (HP:0002307)2.05350857
95Stridor (HP:0010307)2.05024241
96Cerebral hemorrhage (HP:0001342)2.04658088
97Cerebral hypomyelination (HP:0006808)2.04446489
98Poor suck (HP:0002033)2.04239087
99Septo-optic dysplasia (HP:0100842)2.03948453
100Nephronophthisis (HP:0000090)2.03245880
101Slow saccadic eye movements (HP:0000514)2.03049581
102Broad foot (HP:0001769)2.02535817
103Hypoplastic female external genitalia (HP:0012815)2.02396276
104Sclerocornea (HP:0000647)2.01710089
105Patchy hypopigmentation of hair (HP:0011365)2.01466650
106Acute encephalopathy (HP:0006846)1.99875405
107Amniotic constriction ring (HP:0009775)1.99731834
108Abnormality of placental membranes (HP:0011409)1.99731834
109Hemiparesis (HP:0001269)1.99535174
110Decreased lacrimation (HP:0000633)1.99488692
111White forelock (HP:0002211)1.98045619
112Dysmetria (HP:0001310)1.94908839
113Thickened helices (HP:0000391)1.94904789
114Specific learning disability (HP:0001328)1.93869021
115Renal hypoplasia (HP:0000089)1.92935044
116Partial agenesis of the corpus callosum (HP:0001338)1.92084773
117Gastrointestinal atresia (HP:0002589)1.91858748
118Abnormality of the septum pellucidum (HP:0007375)1.91696050
119Colon cancer (HP:0003003)1.91621008
120Supernumerary spleens (HP:0009799)1.90339249
121Xanthomatosis (HP:0000991)1.89640918
122Anteriorly placed anus (HP:0001545)1.88834206
123Progressive inability to walk (HP:0002505)1.88689071
124Hypoplastic heart (HP:0001961)1.88516228
125Narrow forehead (HP:0000341)1.88095525
126Pheochromocytoma (HP:0002666)1.87948679
127Anophthalmia (HP:0000528)1.86640238
128Lissencephaly (HP:0001339)1.86489473
129Bile duct proliferation (HP:0001408)1.85539096
130Abnormal biliary tract physiology (HP:0012439)1.85539096
131Relative macrocephaly (HP:0004482)1.85026860
132Poor coordination (HP:0002370)1.84878217
133Occipital encephalocele (HP:0002085)1.84777952
134Paraparesis (HP:0002385)1.84269486
135Methylmalonic aciduria (HP:0012120)1.83663451
136Abnormality of the vitreous humor (HP:0004327)1.82483191
137Brittle hair (HP:0002299)1.82300048
138Renal cortical cysts (HP:0000803)1.82146981
139Hyperlipoproteinemia (HP:0010980)1.81663448
140Split foot (HP:0001839)1.80709220
141Erythroderma (HP:0001019)1.80397101
142Scanning speech (HP:0002168)1.80337541
143Metaphyseal dysplasia (HP:0100255)1.79137092
144Abnormality of incisor morphology (HP:0011063)1.78046492
145Premature skin wrinkling (HP:0100678)1.77639713
146Limb dystonia (HP:0002451)1.77630511
147Postnatal microcephaly (HP:0005484)1.77006813
148Meningocele (HP:0002435)1.75693852
149Segmental peripheral demyelination/remyelination (HP:0003481)1.74110510
150Delayed epiphyseal ossification (HP:0002663)1.73902327
151Progressive macrocephaly (HP:0004481)1.73784399
152Absent eyebrow (HP:0002223)1.73487173
153Excessive salivation (HP:0003781)1.73460059
154Abnormality of methionine metabolism (HP:0010901)1.73232253
155Hypobetalipoproteinemia (HP:0003563)1.72763973
156Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.72147998
157Reduced antithrombin III activity (HP:0001976)1.71529606
158Exercise-induced muscle cramps (HP:0003710)1.70002873
159Hemivertebrae (HP:0002937)1.69520998
160Neuroendocrine neoplasm (HP:0100634)1.67909546
161Abnormal respiratory epithelium morphology (HP:0012253)1.66884748
162Abnormal respiratory motile cilium morphology (HP:0005938)1.66884748
163Abnormal tarsal ossification (HP:0008369)1.66765882
164Decreased testicular size (HP:0008734)1.66633989
165Mitochondrial inheritance (HP:0001427)1.65998740
166Micropenis (HP:0000054)1.65841871
167Hypoglycemic coma (HP:0001325)1.65832835
168Bifid scrotum (HP:0000048)1.65398851
169Facial hemangioma (HP:0000329)1.65132649
170Abnormality of the metopic suture (HP:0005556)1.64935495
171Preaxial hand polydactyly (HP:0001177)1.64725672
172Hypothermia (HP:0002045)1.64676336
173Abnormality of the renal medulla (HP:0100957)1.64513436
174Abnormality of the labia (HP:0000058)1.64260736
175Abnormal mitochondria in muscle tissue (HP:0008316)1.63842724
176Male pseudohermaphroditism (HP:0000037)1.63506315
177Dandy-Walker malformation (HP:0001305)1.63466044
178Neoplasm of the adrenal gland (HP:0100631)1.62234143
179Bicornuate uterus (HP:0000813)1.59924999
180Abnormality of alanine metabolism (HP:0010916)1.59279161
181Hyperalaninemia (HP:0003348)1.59279161
182Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59279161
183Optic nerve hypoplasia (HP:0000609)1.59223921
184Absent hair (HP:0002298)1.58297052
185Inability to walk (HP:0002540)1.58256669
186Esophageal atresia (HP:0002032)1.58233947
187Cystic liver disease (HP:0006706)1.57362917
188Fragile nails (HP:0001808)1.55501543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.65050028
2OXSR13.62573273
3PBK3.45360330
4WNK33.37009477
5TRIM283.28696405
6EPHB13.28377435
7BCR2.87703732
8MUSK2.67666917
9MAPKAPK52.65539817
10TNIK2.64436624
11MAP3K42.54457233
12MST42.48688054
13PKN12.47693708
14TSSK62.40305833
15MAP4K22.36025475
16WNK42.33733711
17ERBB32.32756360
18NEK12.21125968
19MET2.15158441
20MAP2K71.93103921
21PNCK1.87840206
22CASK1.87630550
23SRPK11.83973982
24LIMK11.83019804
25BMPR1B1.82485234
26EPHA41.71015175
27CSNK1G31.70243974
28FGFR21.68431314
29NTRK11.67612751
30EIF2AK31.64000504
31FRK1.63049733
32MKNK21.62982980
33FGR1.61899035
34UHMK11.61418115
35CSNK1A1L1.51907742
36PLK41.46330149
37NEK61.45161205
38PLK31.42336437
39MARK11.41336380
40WNK11.40374281
41CSNK1G21.40060192
42WEE11.39799007
43CSNK1G11.37046204
44CDK191.31629664
45PINK11.31313706
46CAMK2B1.31223724
47EPHB21.31217848
48ERBB41.29954421
49ACVR1B1.26528584
50DYRK21.25897518
51MAPK151.25095178
52ZAK1.24039161
53BCKDK1.22171321
54ROCK21.19986561
55DYRK31.17355670
56CAMK2D1.13446539
57EPHA31.11869419
58MINK11.08531953
59SGK2231.05362569
60SGK4941.05362569
61VRK10.95164107
62MAPK130.94308884
63IRAK20.93869058
64FER0.93760397
65CAMK2A0.93510261
66TESK20.92706193
67PRKCE0.90609047
68PHKG10.89921312
69PHKG20.89921312
70NTRK20.88430148
71PRKCQ0.86643041
72CLK10.84687378
73TGFBR10.83592371
74PAK30.82651185
75CAMK2G0.81794555
76ADRBK20.79347585
77EIF2AK10.78534758
78BRSK20.77332500
79BUB10.74368587
80PRPF4B0.70683068
81NTRK30.70485326
82CDK140.70057361
83DDR20.68935358
84PLK10.67250378
85TYRO30.66671024
86RPS6KA40.65022936
87SIK30.64935968
88CDK50.64659596
89GRK70.64502429
90IRAK10.63649322
91TTK0.62360054
92PLK20.61926780
93STK160.61492672
94CDK150.59628256
95DYRK1A0.59551871
96YES10.58393139
97CDK180.56170102
98MAP3K120.56004486
99FLT30.55631110
100INSRR0.55067567
101MKNK10.54835509
102FGFR10.53644906
103GSK3A0.52649006
104CDK11A0.52453111
105PRKG10.52436209
106RPS6KA50.51848806
107MAP2K40.50893298
108CSNK1D0.49823758
109AKT30.49497802
110MARK20.49307480
111STK38L0.48891754
112LATS10.47657159
113NME10.47100794
114ADRBK10.46726695
115PAK60.46562619
116PRKD10.44783147
117CSNK1A10.43854660
118ERBB20.42699780
119FYN0.42385872
120MAPK70.41551762
121PRKACA0.41265405
122NUAK10.41100045
123TRPM70.40860388
124ARAF0.40616219
125BMPR20.40529561
126KSR10.40349471
127PDPK10.40111700
128TAF10.38544648
129PIM20.37645198
130NEK90.37504183
131ROCK10.35973544
132ATM0.35873173
133PRKACB0.35820971
134PDK20.35776844
135ICK0.34871374
136GRK10.34732988
137MAPK120.33471290
138TIE10.33434824
139CSNK1E0.32601675
140MAP2K20.31497607
141PRKCG0.31236659
142LMTK20.31071969
143GRK50.30510594
144EIF2AK20.30002001
145ABL20.29985075
146MST1R0.29470041
147INSR0.28156379
148PIK3CA0.27733873
149PRKCA0.26392181
150FES0.26223510
151IRAK30.25592797
152EPHA20.25424039
153MAPK40.24149277

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.94677911
2* Steroid biosynthesis_Homo sapiens_hsa001005.63936456
3Fatty acid elongation_Homo sapiens_hsa000624.41513409
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.37671326
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.45569567
6Ether lipid metabolism_Homo sapiens_hsa005652.45243450
7Sulfur metabolism_Homo sapiens_hsa009202.28889857
8Butanoate metabolism_Homo sapiens_hsa006502.16654939
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12133434
10Oxidative phosphorylation_Homo sapiens_hsa001902.00942063
11Histidine metabolism_Homo sapiens_hsa003401.99850354
12Fatty acid metabolism_Homo sapiens_hsa012121.77183599
13Protein export_Homo sapiens_hsa030601.75173538
14Sphingolipid metabolism_Homo sapiens_hsa006001.71669524
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66002625
16Caffeine metabolism_Homo sapiens_hsa002321.53553718
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51326389
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49610380
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49559093
20Vitamin B6 metabolism_Homo sapiens_hsa007501.48851867
21Fatty acid biosynthesis_Homo sapiens_hsa000611.47107342
22Parkinsons disease_Homo sapiens_hsa050121.35074939
23Linoleic acid metabolism_Homo sapiens_hsa005911.34775383
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31805540
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.31032209
26Peroxisome_Homo sapiens_hsa041461.24248415
27Arginine and proline metabolism_Homo sapiens_hsa003301.23504657
28Alzheimers disease_Homo sapiens_hsa050101.20333958
29Nitrogen metabolism_Homo sapiens_hsa009101.20289671
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.20218641
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.18605250
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17140645
33Propanoate metabolism_Homo sapiens_hsa006401.14961983
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14665807
35Chemical carcinogenesis_Homo sapiens_hsa052041.05042468
36Basal transcription factors_Homo sapiens_hsa030220.99404444
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98885102
38Tyrosine metabolism_Homo sapiens_hsa003500.97024317
39Retinol metabolism_Homo sapiens_hsa008300.96334484
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95015977
41Axon guidance_Homo sapiens_hsa043600.94635423
42Fatty acid degradation_Homo sapiens_hsa000710.91931117
43Glutathione metabolism_Homo sapiens_hsa004800.91764591
44Serotonergic synapse_Homo sapiens_hsa047260.90919862
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90682949
46Carbon metabolism_Homo sapiens_hsa012000.90125376
47Selenocompound metabolism_Homo sapiens_hsa004500.84589011
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82287911
49Biosynthesis of amino acids_Homo sapiens_hsa012300.80876163
50Vitamin digestion and absorption_Homo sapiens_hsa049770.80429213
51Non-homologous end-joining_Homo sapiens_hsa034500.79912219
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79743180
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79458911
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79302182
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77053424
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76652773
57Fanconi anemia pathway_Homo sapiens_hsa034600.73991197
58Collecting duct acid secretion_Homo sapiens_hsa049660.73401895
59Arachidonic acid metabolism_Homo sapiens_hsa005900.72705670
60Tryptophan metabolism_Homo sapiens_hsa003800.70842924
61RNA degradation_Homo sapiens_hsa030180.70323157
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69111500
63Pyruvate metabolism_Homo sapiens_hsa006200.66742981
64Glutamatergic synapse_Homo sapiens_hsa047240.66516650
65Huntingtons disease_Homo sapiens_hsa050160.66377527
66* Metabolic pathways_Homo sapiens_hsa011000.65670721
67Folate biosynthesis_Homo sapiens_hsa007900.65409730
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65029468
69GABAergic synapse_Homo sapiens_hsa047270.64779259
70Ovarian steroidogenesis_Homo sapiens_hsa049130.63174672
71Phenylalanine metabolism_Homo sapiens_hsa003600.62966254
72PPAR signaling pathway_Homo sapiens_hsa033200.62195828
73RNA polymerase_Homo sapiens_hsa030200.61177848
74beta-Alanine metabolism_Homo sapiens_hsa004100.60149344
75Basal cell carcinoma_Homo sapiens_hsa052170.58101254
76Rheumatoid arthritis_Homo sapiens_hsa053230.57427438
77Hippo signaling pathway_Homo sapiens_hsa043900.56849183
78N-Glycan biosynthesis_Homo sapiens_hsa005100.56401733
79Vibrio cholerae infection_Homo sapiens_hsa051100.55776977
80Cocaine addiction_Homo sapiens_hsa050300.55568715
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.54735360
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51527215
83Starch and sucrose metabolism_Homo sapiens_hsa005000.51481858
84Mineral absorption_Homo sapiens_hsa049780.51402123
85Complement and coagulation cascades_Homo sapiens_hsa046100.51316690
86Taste transduction_Homo sapiens_hsa047420.50087367
87Long-term depression_Homo sapiens_hsa047300.49469072
88TGF-beta signaling pathway_Homo sapiens_hsa043500.47790979
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47510598
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45612242
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44906682
92Nucleotide excision repair_Homo sapiens_hsa034200.44084009
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43901758
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.43397942
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41758532
96RNA transport_Homo sapiens_hsa030130.41385850
97Bile secretion_Homo sapiens_hsa049760.41077582
98Autoimmune thyroid disease_Homo sapiens_hsa053200.41005100
99Arginine biosynthesis_Homo sapiens_hsa002200.40370964
100Homologous recombination_Homo sapiens_hsa034400.40167483
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40016716
102Nicotine addiction_Homo sapiens_hsa050330.39380086
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39163548
104ECM-receptor interaction_Homo sapiens_hsa045120.38668557
105Phagosome_Homo sapiens_hsa041450.38507112
106Dopaminergic synapse_Homo sapiens_hsa047280.37876108
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37253042
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36530388
109Lysine degradation_Homo sapiens_hsa003100.36072627
110Mismatch repair_Homo sapiens_hsa034300.35420611
111One carbon pool by folate_Homo sapiens_hsa006700.33330810
112Malaria_Homo sapiens_hsa051440.32681881
113Fat digestion and absorption_Homo sapiens_hsa049750.31570912
114Tight junction_Homo sapiens_hsa045300.30696728
115ABC transporters_Homo sapiens_hsa020100.28640959
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27926118
117Morphine addiction_Homo sapiens_hsa050320.27726521
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26436133
119Lysosome_Homo sapiens_hsa041420.25882511
120Renal cell carcinoma_Homo sapiens_hsa052110.25871529
121Cardiac muscle contraction_Homo sapiens_hsa042600.25069478
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.23979562
123Prion diseases_Homo sapiens_hsa050200.22418712
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22238670
125Phototransduction_Homo sapiens_hsa047440.22197691
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22129226
127Ras signaling pathway_Homo sapiens_hsa040140.20673413
128Glycerolipid metabolism_Homo sapiens_hsa005610.20426622
129Dorso-ventral axis formation_Homo sapiens_hsa043200.17825203
130Hedgehog signaling pathway_Homo sapiens_hsa043400.17323770
131Salivary secretion_Homo sapiens_hsa049700.17141693
132Proteasome_Homo sapiens_hsa030500.17048922
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14484171
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14366198

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