MSMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)8.45664481
2detection of light stimulus involved in visual perception (GO:0050908)7.99618220
3detection of light stimulus involved in sensory perception (GO:0050962)7.99618220
4axon extension involved in axon guidance (GO:0048846)7.69719424
5neuron projection extension involved in neuron projection guidance (GO:1902284)7.69719424
6positive regulation of pseudopodium assembly (GO:0031274)7.50145905
7thrombin receptor signaling pathway (GO:0070493)7.49197709
8positive regulation of Rho protein signal transduction (GO:0035025)7.44328524
9positive regulation of actin filament depolymerization (GO:0030836)7.25990970
10ganglion development (GO:0061548)7.21642880
11signal complex assembly (GO:0007172)7.11630602
12response to pheromone (GO:0019236)6.73614601
13regulation of pseudopodium assembly (GO:0031272)6.73205905
14branching involved in prostate gland morphogenesis (GO:0060442)6.51006929
15facial nerve structural organization (GO:0021612)6.44274535
16negative regulation of axon extension involved in axon guidance (GO:0048843)6.35079128
17regulation of glomerular filtration (GO:0003093)6.26343480
18endothelial cell chemotaxis (GO:0035767)6.02689342
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071996.01317148
20retinal cone cell development (GO:0046549)6.00007586
21positive regulation of interleukin-8 secretion (GO:2000484)5.99753974
22retina vasculature morphogenesis in camera-type eye (GO:0061299)5.82596131
23regulation of chemokine secretion (GO:0090196)5.58045134
24regulation of rhodopsin mediated signaling pathway (GO:0022400)5.40284178
25growth hormone receptor signaling pathway (GO:0060396)5.36633089
26interferon-gamma secretion (GO:0072643)5.34707802
27nucleotide transmembrane transport (GO:1901679)5.31687383
28epithelial cell maturation (GO:0002070)5.26963671
29activation of Rac GTPase activity (GO:0032863)5.25173394
30negative regulation of synaptic transmission, GABAergic (GO:0032229)5.16604630
31endoderm formation (GO:0001706)5.08420824
32rhodopsin mediated signaling pathway (GO:0016056)5.07396413
33regulation of cGMP metabolic process (GO:0030823)5.04768373
34negative regulation of axon guidance (GO:1902668)5.04512044
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.94072196
36positive regulation of protein kinase C signaling (GO:0090037)4.92968581
37protein localization to endosome (GO:0036010)4.87751950
38regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.80921404
39galactose catabolic process (GO:0019388)4.77893552
40positive regulation of cGMP metabolic process (GO:0030825)4.73602395
41substrate-dependent cell migration (GO:0006929)4.71658379
42negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.67775867
43cellular response to growth hormone stimulus (GO:0071378)4.67599033
44N-acetylneuraminate metabolic process (GO:0006054)4.67146772
45cell volume homeostasis (GO:0006884)4.62522176
46positive regulation of guanylate cyclase activity (GO:0031284)4.58335682
47extracellular matrix assembly (GO:0085029)4.53660447
48regulation of cytokine secretion involved in immune response (GO:0002739)4.50545789
49negative regulation of cell fate specification (GO:0009996)4.50389365
50cranial nerve structural organization (GO:0021604)4.45550544
51positive regulation of action potential (GO:0045760)4.42950611
52negative regulation of osteoblast proliferation (GO:0033689)4.42928609
53regulation of receptor binding (GO:1900120)4.39466910
54somite rostral/caudal axis specification (GO:0032525)4.34215778
55negative regulation of skeletal muscle tissue development (GO:0048642)4.26505642
56regulation of superoxide anion generation (GO:0032928)4.22961154
57response to hepatocyte growth factor (GO:0035728)4.21440381
58cellular response to hepatocyte growth factor stimulus (GO:0035729)4.21440381
59regulation of sister chromatid cohesion (GO:0007063)4.20997894
60positive regulation of cGMP biosynthetic process (GO:0030828)4.18866629
61regulation of guanylate cyclase activity (GO:0031282)4.17051950
62protein maturation by protein folding (GO:0022417)4.14825579
63renal system process involved in regulation of blood volume (GO:0001977)4.14813080
64coronary vasculature morphogenesis (GO:0060977)4.08493158
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07440071
66UDP-N-acetylglucosamine metabolic process (GO:0006047)4.03668126
67photoreceptor cell development (GO:0042461)3.98978288
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.97754690
69stress fiber assembly (GO:0043149)3.97386853
70regulation of cGMP biosynthetic process (GO:0030826)3.95830406
71eye photoreceptor cell development (GO:0042462)3.93038760
72positive regulation of leukocyte degranulation (GO:0043302)3.90613519
73positive regulation of protein depolymerization (GO:1901881)3.90012437
74long term synaptic depression (GO:0060292)3.84167758
75paraxial mesoderm development (GO:0048339)3.82112003
76regulation of synaptic transmission, dopaminergic (GO:0032225)3.79558768
77photoreceptor cell maintenance (GO:0045494)3.78567816
78regulation of somitogenesis (GO:0014807)3.75932381
79regulation of catecholamine metabolic process (GO:0042069)3.75891038
80regulation of dopamine metabolic process (GO:0042053)3.75891038
81prostate gland epithelium morphogenesis (GO:0060740)3.75166819
82pyrimidine nucleobase catabolic process (GO:0006208)3.73552844
83negative regulation of fatty acid biosynthetic process (GO:0045717)3.72742364
84neuron fate determination (GO:0048664)3.71729986
85negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.71655928
86negative regulation of chemokine production (GO:0032682)3.67589869
87positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.65971826
88response to testosterone (GO:0033574)3.63598689
89adrenergic receptor signaling pathway (GO:0071875)3.63036998
90renal filtration (GO:0097205)3.62406688
91retinal rod cell development (GO:0046548)3.59481492
92type B pancreatic cell proliferation (GO:0044342)3.57666816
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.54048664
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.54048664
95regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.53240207
96detection of light stimulus (GO:0009583)3.50590810
97regulation of axon extension involved in axon guidance (GO:0048841)3.50052206
98semaphorin-plexin signaling pathway (GO:0071526)3.49635888
99regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.47319228
100negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46945230
101protein localization to microtubule (GO:0035372)3.45777320
102regulation of interleukin-8 secretion (GO:2000482)3.41788328
103convergent extension (GO:0060026)3.41373837
104receptor guanylyl cyclase signaling pathway (GO:0007168)3.40306960
105axon extension (GO:0048675)3.39806310
106positive regulation of systemic arterial blood pressure (GO:0003084)3.39784532
107glycerol ether metabolic process (GO:0006662)3.38797308
108positive regulation of gastrulation (GO:2000543)3.37408487
109adherens junction assembly (GO:0034333)3.35003048
110histone H4 deacetylation (GO:0070933)3.34737498
111neuromuscular process controlling posture (GO:0050884)3.34564104
112positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.30564622
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29854031
114cellular copper ion homeostasis (GO:0006878)3.28452457
115detection of visible light (GO:0009584)3.25585739
116mesoderm formation (GO:0001707)3.24744605
117adult feeding behavior (GO:0008343)3.23896690
118negative regulation of cell fate commitment (GO:0010454)3.22369718
119neural crest cell migration (GO:0001755)3.21766609
120regulation of voltage-gated calcium channel activity (GO:1901385)3.21459303
121urinary tract smooth muscle contraction (GO:0014848)3.19516078
122dopaminergic neuron differentiation (GO:0071542)3.18317824
123glomerular basement membrane development (GO:0032836)3.18053473
124extracellular negative regulation of signal transduction (GO:1900116)3.17187380
125extracellular regulation of signal transduction (GO:1900115)3.17187380
126sequestering of metal ion (GO:0051238)3.16726689
127regulation of penile erection (GO:0060405)3.16652982
128pentose-phosphate shunt (GO:0006098)3.16044324
129glycogen catabolic process (GO:0005980)3.14351726
130synaptic vesicle exocytosis (GO:0016079)3.12612544
131ether lipid metabolic process (GO:0046485)3.12413795
132phototransduction (GO:0007602)3.10934788
133neuron projection regeneration (GO:0031102)3.09731620
134formation of primary germ layer (GO:0001704)3.08844898
135cell migration involved in sprouting angiogenesis (GO:0002042)3.07411308
136ether metabolic process (GO:0018904)3.05369853
137muscle cell migration (GO:0014812)3.04637135
138placenta blood vessel development (GO:0060674)3.02727860
139skin morphogenesis (GO:0043589)3.02253969
140detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.01228638
141detection of temperature stimulus involved in sensory perception (GO:0050961)3.01228638
142positive regulation of cell fate commitment (GO:0010455)2.99792658
143nucleotide transport (GO:0006862)2.99365115
144regulation of axon guidance (GO:1902667)2.99100201
145NADPH regeneration (GO:0006740)2.98786090
146diterpenoid biosynthetic process (GO:0016102)2.98551632
147galactose metabolic process (GO:0006012)2.98464300
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.97595184
149protein retention in ER lumen (GO:0006621)2.94248248
150regulation of collateral sprouting (GO:0048670)2.93932120
151histone H3 deacetylation (GO:0070932)2.93387033
152visual perception (GO:0007601)2.90033076
153regulation of Rho protein signal transduction (GO:0035023)2.89774391
154regulation of transforming growth factor beta2 production (GO:0032909)2.89706715
155glucan catabolic process (GO:0009251)2.89606908
156keratinocyte proliferation (GO:0043616)2.89106064
157anatomical structure arrangement (GO:0048532)2.88590742
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87630659
159sensory perception of light stimulus (GO:0050953)2.86850407
160GDP-mannose metabolic process (GO:0019673)2.86819771
161negative regulation of cardiac muscle tissue development (GO:0055026)2.86069521
162focal adhesion assembly (GO:0048041)2.85607498
163cell-substrate adherens junction assembly (GO:0007045)2.85607498
164neuron projection extension (GO:1990138)2.84967341
165regulation of protein kinase C signaling (GO:0090036)2.84742538
166regulation of neuron projection regeneration (GO:0070570)2.84660132
167regulation of axon regeneration (GO:0048679)2.84660132
168axon regeneration (GO:0031103)2.84097982
169regulation of Rac GTPase activity (GO:0032314)2.82997270
170renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.82132120
171response to cocaine (GO:0042220)2.82071599
172positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.82015930
173response to misfolded protein (GO:0051788)2.80115327
174glycolytic process (GO:0006096)2.80000226
175negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.79033845
176vasculature development (GO:0001944)2.78667589
177regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.78224994
178cell morphogenesis involved in neuron differentiation (GO:0048667)2.78142548
179negative regulation of activin receptor signaling pathway (GO:0032926)2.77838451
180motor neuron axon guidance (GO:0008045)2.77825245
181phototransduction, visible light (GO:0007603)2.76908564
182cellular potassium ion homeostasis (GO:0030007)2.74915977
183nucleobase catabolic process (GO:0046113)2.74419059
184detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.72203722
185positive regulation of sodium ion transmembrane transport (GO:1902307)2.71491006
186potassium ion homeostasis (GO:0055075)2.69961832
187positive regulation of astrocyte differentiation (GO:0048711)2.68883790
188negative regulation of glycogen biosynthetic process (GO:0045719)2.68547275
189primitive streak formation (GO:0090009)2.67931271
190retina development in camera-type eye (GO:0060041)2.62452437
191membrane hyperpolarization (GO:0060081)2.62432278
192male sex determination (GO:0030238)2.62177096
193planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60306582
194C4-dicarboxylate transport (GO:0015740)2.60256206
195positive regulation of fatty acid beta-oxidation (GO:0032000)2.60024951
196negative regulation of glial cell differentiation (GO:0045686)2.57329304
197negative regulation of TOR signaling (GO:0032007)2.56600102
198positive regulation of TOR signaling (GO:0032008)2.56585472
199prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:00605210.1022208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.60292682
2SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.53383169
3ZNF263_19887448_ChIP-Seq_K562_Human3.44736528
4EED_16625203_ChIP-ChIP_MESCs_Mouse3.37167811
5ZIC3_20872845_ChIP-ChIP_MESCs_Mouse3.28401989
6JARID2_20075857_ChIP-Seq_MESCs_Mouse3.18127179
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.16191555
8EZH2_27304074_Chip-Seq_ESCs_Mouse3.12363821
9SUZ12_27294783_Chip-Seq_ESCs_Mouse2.94464739
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.83810412
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.79885708
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.76574473
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72218484
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71113631
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.70331170
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61284204
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54270979
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51801965
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51801965
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.51453638
21OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.49991196
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47793545
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.47273217
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.40376147
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36041935
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35458364
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35458364
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35458364
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.35102242
30TP53_20018659_ChIP-ChIP_R1E_Mouse2.33528250
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26674620
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.23047470
33SRY_22984422_ChIP-ChIP_TESTIS_Rat2.22967940
34TRIM28_21343339_ChIP-Seq_HEK293_Human2.16991458
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09037375
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07764085
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06582881
38MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05945389
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.02893218
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00804747
41RACK7_27058665_Chip-Seq_MCF-7_Human1.99459616
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.90934243
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.90238664
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.88246265
45CTCF_27219007_Chip-Seq_Bcells_Human1.85192847
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82140941
47LXR_22292898_ChIP-Seq_THP-1_Human1.81885604
48CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.78285486
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76805865
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73783360
51REST_21632747_ChIP-Seq_MESCs_Mouse1.72216715
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71234765
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69249038
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.68880104
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64738526
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64568637
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61741449
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60821566
59HTT_18923047_ChIP-ChIP_STHdh_Human1.58900337
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.57579219
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.56778094
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56453473
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55006997
64ATF3_27146783_Chip-Seq_COLON_Human1.54118229
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.52370351
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51745079
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.50600682
68EOMES_21245162_ChIP-Seq_HESCs_Human1.50073657
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.46187441
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.45317547
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45086399
72JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.44842463
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.43510264
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42801470
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42692778
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41465911
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37426673
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37412560
79MYC_22102868_ChIP-Seq_BL_Human1.36544819
80ERG_20517297_ChIP-Seq_VCAP_Human1.35638665
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34182863
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34177517
83CTCF_20526341_ChIP-Seq_ESCs_Human1.33532632
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.33473125
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.32816264
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32144244
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31890333
88DROSHA_22980978_ChIP-Seq_HELA_Human1.31341001
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31240850
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31112472
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28362558
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28159711
93VDR_21846776_ChIP-Seq_THP-1_Human1.27085563
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20272018
95CREB1_26743006_Chip-Seq_LNCaP_Human1.20204125
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19118534
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19087092
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18628776
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18331102
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17243596
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17224546
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.16014929
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15671955
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15272385
105NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.14339391
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14261222
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12277463
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12049332
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11624374
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10655984
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10429719
112KDM2B_26808549_Chip-Seq_DND41_Human1.10295829
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09946541
114CHD1_26751641_Chip-Seq_LNCaP_Human1.08493353
115SA1_27219007_Chip-Seq_Bcells_Human1.07430263
116TET1_21490601_ChIP-Seq_MESCs_Mouse1.06985177
117TP53_22127205_ChIP-Seq_IMR90_Human1.06204575
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06019837
119* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05582557
120KDM2B_26808549_Chip-Seq_K562_Human1.05308674
121BCL6_27268052_Chip-Seq_Bcells_Human1.03890386
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03674364
123CLOCK_20551151_ChIP-Seq_293T_Human1.03291971
124STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03184139
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02495221
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02308833
127SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02195292
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.02036059
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01918193
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00329768
131XRN2_22483619_ChIP-Seq_HELA_Human0.99788586
132PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99756075
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99687398
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99075605
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98455904
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.98295255
137VDR_22108803_ChIP-Seq_LS180_Human0.97646035
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96933878
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.96832752
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96209130
141GATA6_25053715_ChIP-Seq_YYC3_Human0.95764031
142RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94949366
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.93935240
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93726996
145CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93699602
146ELF5_23300383_ChIP-Seq_T47D_Human0.93695074
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92805915
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92486760
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92047100
150TP53_23651856_ChIP-Seq_MEFs_Mouse0.91657020
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91632472
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91325861
153GATA1_26923725_Chip-Seq_HPCs_Mouse0.90927241
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90921782
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.90889563
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90848829
157SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90848829
158TCF7_22412390_ChIP-Seq_EML_Mouse0.90501383
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90224513
160SMC4_20622854_ChIP-Seq_HELA_Human0.88853423
161RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88711754
162E2F1_20622854_ChIP-Seq_HELA_Human0.88548551
163P68_20966046_ChIP-Seq_HELA_Human0.88358437
164EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87936129
165SRF_21415370_ChIP-Seq_HL-1_Mouse0.86493579
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85865109
167NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85665650
168ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85166803
169IRF1_19129219_ChIP-ChIP_H3396_Human0.84570603
170UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84319390
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84314063
172CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83672622
173STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82984400
174RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82772417
175PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82396561
176PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82383464
177FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81747414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.66700706
2MP0005551_abnormal_eye_electrophysiolog4.51553732
3MP0000537_abnormal_urethra_morphology4.08509027
4MP0010030_abnormal_orbit_morphology3.40283177
5MP0001986_abnormal_taste_sensitivity3.34291901
6MP0002653_abnormal_ependyma_morphology3.19921495
7MP0001529_abnormal_vocalization3.14549451
8MP0009840_abnormal_foam_cell3.13720098
9MP0003011_delayed_dark_adaptation3.05394134
10MP0005253_abnormal_eye_physiology2.89501670
11MP0008438_abnormal_cutaneous_collagen2.81411049
12MP0000566_synostosis2.73276109
13MP0006072_abnormal_retinal_apoptosis2.68985180
14MP0003329_amyloid_beta_deposits2.65368731
15MP0005670_abnormal_white_adipose2.54680478
16MP0002332_abnormal_exercise_endurance2.49616440
17MP0005423_abnormal_somatic_nervous2.39296345
18MP0002006_tumorigenesis2.38227521
19MP0000467_abnormal_esophagus_morphology2.33907970
20MP0000003_abnormal_adipose_tissue2.28283390
21MP0001915_intracranial_hemorrhage2.27810292
22MP0004185_abnormal_adipocyte_glucose2.16153440
23MP0004147_increased_porphyrin_level2.15976993
24MP0005195_abnormal_posterior_eye2.11684094
25MP0005084_abnormal_gallbladder_morpholo2.11425272
26MP0002089_abnormal_postnatal_growth/wei2.07559083
27MP0002638_abnormal_pupillary_reflex2.06371403
28MP0003121_genomic_imprinting2.05199986
29MP0002090_abnormal_vision2.02664329
30MP0003191_abnormal_cellular_cholesterol1.99777562
31MP0010368_abnormal_lymphatic_system1.98262987
32MP0003172_abnormal_lysosome_physiology1.92427592
33MP0005647_abnormal_sex_gland1.92226300
34MP0005083_abnormal_biliary_tract1.91677844
35MP0005623_abnormal_meninges_morphology1.83579424
36MP0003091_abnormal_cell_migration1.83031678
37MP0003566_abnormal_cell_adhesion1.82015780
38MP0003279_aneurysm1.73910074
39MP0000013_abnormal_adipose_tissue1.70686227
40MP0010386_abnormal_urinary_bladder1.67456465
41MP0003937_abnormal_limbs/digits/tail_de1.66816360
42MP0004510_myositis1.65357055
43MP0008789_abnormal_olfactory_epithelium1.64779027
44MP0005266_abnormal_metabolism1.64710500
45MP0004215_abnormal_myocardial_fiber1.59673436
46MP0009053_abnormal_anal_canal1.57882925
47MP0005166_decreased_susceptibility_to1.54068662
48MP0005076_abnormal_cell_differentiation1.50219880
49MP0002837_dystrophic_cardiac_calcinosis1.48066439
50MP0005595_abnormal_vascular_smooth1.47918838
51MP0005377_hearing/vestibular/ear_phenot1.47625762
52MP0003878_abnormal_ear_physiology1.47625762
53MP0001727_abnormal_embryo_implantation1.46958925
54MP0001324_abnormal_eye_pigmentation1.45194650
55MP0001502_abnormal_circadian_rhythm1.44788957
56MP0008260_abnormal_autophagy1.44382267
57MP0001348_abnormal_lacrimal_gland1.43795376
58MP0003075_altered_response_to1.43489819
59MP0000749_muscle_degeneration1.43215829
60MP0005023_abnormal_wound_healing1.42472741
61MP0003119_abnormal_digestive_system1.41854973
62MP0005164_abnormal_response_to1.39579396
63MP0005499_abnormal_olfactory_system1.38867172
64MP0005394_taste/olfaction_phenotype1.38867172
65MP0005501_abnormal_skin_physiology1.38194148
66MP0005085_abnormal_gallbladder_physiolo1.36554858
67MP0000462_abnormal_digestive_system1.34648255
68MP0006276_abnormal_autonomic_nervous1.34175582
69MP0005391_vision/eye_phenotype1.32131918
70MP0000569_abnormal_digit_pigmentation1.31546429
71MP0004272_abnormal_basement_membrane1.31511881
72MP0008961_abnormal_basal_metabolism1.30992823
73MP0005220_abnormal_exocrine_pancreas1.28990594
74MP0004782_abnormal_surfactant_physiolog1.28493418
75MP0001984_abnormal_olfaction1.26954453
76MP0003879_abnormal_hair_cell1.25780351
77MP0004233_abnormal_muscle_weight1.25455754
78MP0002184_abnormal_innervation1.25120309
79MP0002234_abnormal_pharynx_morphology1.25027540
80MP0005503_abnormal_tendon_morphology1.20649592
81MP0003436_decreased_susceptibility_to1.19271082
82MP0003283_abnormal_digestive_organ1.18575802
83MP0004859_abnormal_synaptic_plasticity1.18560101
84MP0000613_abnormal_salivary_gland1.17244627
85MP0002752_abnormal_somatic_nervous1.17000421
86MP0003122_maternal_imprinting1.16674053
87MP0002168_other_aberrant_phenotype1.15769344
88MP0003950_abnormal_plasma_membrane1.14150392
89MP0001346_abnormal_lacrimal_gland1.12242111
90MP0003935_abnormal_craniofacial_develop1.12019697
91MP0003959_abnormal_lean_body1.11874806
92MP0002925_abnormal_cardiovascular_devel1.10918786
93MP0000678_abnormal_parathyroid_gland1.10616672
94MP0001664_abnormal_digestion1.09108083
95MP0002933_joint_inflammation1.07863928
96MP0000778_abnormal_nervous_system1.07771995
97MP0001533_abnormal_skeleton_physiology1.03427753
98MP0006292_abnormal_olfactory_placode1.02670958
99MP0002272_abnormal_nervous_system1.02365260
100MP0000762_abnormal_tongue_morphology1.01768218
101MP0006054_spinal_hemorrhage1.01446622
102MP0001216_abnormal_epidermal_layer0.98900044
103MP0002736_abnormal_nociception_after0.98722704
104MP0005375_adipose_tissue_phenotype0.98685066
105MP0000858_altered_metastatic_potential0.97495237
106MP0004142_abnormal_muscle_tone0.97364104
107MP0003705_abnormal_hypodermis_morpholog0.96911145
108MP0002882_abnormal_neuron_morphology0.96414520
109MP0000604_amyloidosis0.96235562
110MP0002060_abnormal_skin_morphology0.96028197
111MP0000631_abnormal_neuroendocrine_gland0.95451114
112MP0008007_abnormal_cellular_replicative0.94837173
113MP0001270_distended_abdomen0.94190684
114MP0008775_abnormal_heart_ventricle0.94041838
115MP0005376_homeostasis/metabolism_phenot0.93622978
116MP0002132_abnormal_respiratory_system0.92507352
117MP0004947_skin_inflammation0.92174958
118MP0002282_abnormal_trachea_morphology0.91847503
119MP0003635_abnormal_synaptic_transmissio0.91562168
120MP0001486_abnormal_startle_reflex0.90921284
121MP0002085_abnormal_embryonic_tissue0.90710529
122MP0002938_white_spotting0.90576604
123MP0004145_abnormal_muscle_electrophysio0.89900130
124MP0001614_abnormal_blood_vessel0.87934665
125MP0002928_abnormal_bile_duct0.87350140
126MP0002127_abnormal_cardiovascular_syste0.86437104
127MP0004270_analgesia0.85522441
128MP0005165_increased_susceptibility_to0.85144297
129MP0000733_abnormal_muscle_development0.84353253
130MP0004811_abnormal_neuron_physiology0.84110018
131MP0001905_abnormal_dopamine_level0.83541777
132MP0005390_skeleton_phenotype0.83260403
133MP0005508_abnormal_skeleton_morphology0.82171486
134MP0002896_abnormal_bone_mineralization0.80559857
135MP0005197_abnormal_uvea_morphology0.80078084
136MP0002932_abnormal_joint_morphology0.79474246
137MP0003634_abnormal_glial_cell0.79305518
138MP0005193_abnormal_anterior_eye0.79120952
139MP0002063_abnormal_learning/memory/cond0.75270216
140MP0003943_abnormal_hepatobiliary_system0.75207219
141MP0000751_myopathy0.75054795
142MP0001970_abnormal_pain_threshold0.74889152
143MP0003453_abnormal_keratinocyte_physiol0.74622626
144MP0001968_abnormal_touch/_nociception0.74005744
145MP0002098_abnormal_vibrissa_morphology0.73624399
146MP0003183_abnormal_peptide_metabolism0.73317382
147MP0000049_abnormal_middle_ear0.72367954
148MP0001849_ear_inflammation0.71993039
149MP0005666_abnormal_adipose_tissue0.70937567
150MP0001188_hyperpigmentation0.70643720
151MP0002557_abnormal_social/conspecific_i0.70427435
152MP0005248_abnormal_Harderian_gland0.69834062
153MP0003868_abnormal_feces_composition0.69557243
154MP0003137_abnormal_impulse_conducting0.68934600
155MP0008932_abnormal_embryonic_tissue0.68546646
156MP0001944_abnormal_pancreas_morphology0.68281909
157MP0002152_abnormal_brain_morphology0.68083815
158MP0003186_abnormal_redox_activity0.67957454
159MP0000534_abnormal_ureter_morphology0.67389587
160MP0005621_abnormal_cell_physiology0.67286987
161MP0000230_abnormal_systemic_arterial0.67066229
162MP0001542_abnormal_bone_strength0.65863544
163MP0001340_abnormal_eyelid_morphology0.65716949
164MP0003861_abnormal_nervous_system0.65573751
165MP0000955_abnormal_spinal_cord0.65566221
166MP0002086_abnormal_extraembryonic_tissu0.65376859
167MP0003315_abnormal_perineum_morphology0.64770402
168MP0004264_abnormal_extraembryonic_tissu0.64661298
169MP0001697_abnormal_embryo_size0.64209994
170MP0004134_abnormal_chest_morphology0.64102763
171MP0000759_abnormal_skeletal_muscle0.63684937
172MP0002796_impaired_skin_barrier0.63446923
173MP0004085_abnormal_heartbeat0.63439712
174MP0003115_abnormal_respiratory_system0.63398260
175MP0002080_prenatal_lethality0.63261399

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.00470417
2Round ear (HP:0100830)5.89548964
3Abnormal rod and cone electroretinograms (HP:0008323)5.51828056
4Toxemia of pregnancy (HP:0100603)5.27084093
5Large earlobe (HP:0009748)4.76709213
6Short 1st metacarpal (HP:0010034)4.68382445
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.68382445
8Neurofibrillary tangles (HP:0002185)4.46530673
9Upper motor neuron abnormality (HP:0002127)4.43712553
10Striae distensae (HP:0001065)4.43152947
11Central scotoma (HP:0000603)4.30866345
12Flat acetabular roof (HP:0003180)4.25662575
13Abnormal tarsal ossification (HP:0008369)4.19551033
14Keratoconus (HP:0000563)4.17500050
15Increased corneal curvature (HP:0100692)4.17500050
16Abnormality of the 1st metacarpal (HP:0010009)4.06531467
17Growth hormone excess (HP:0000845)4.02648829
18Radial bowing (HP:0002986)4.00240284
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.92647982
20Severe visual impairment (HP:0001141)3.90579664
21Bony spicule pigmentary retinopathy (HP:0007737)3.82738421
22Epileptic encephalopathy (HP:0200134)3.75681076
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72050531
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72050531
25Decreased central vision (HP:0007663)3.66907447
26Ulnar bowing (HP:0003031)3.64336353
27Abnormality of macular pigmentation (HP:0008002)3.56965462
28Flattened epiphyses (HP:0003071)3.53251356
29Abnormal foot bone ossification (HP:0010675)3.47815302
30Abnormality of the distal phalanges of the toes (HP:0010182)3.44876578
31Cerebral inclusion bodies (HP:0100314)3.44072767
32Protrusio acetabuli (HP:0003179)3.38170768
33Pigmentary retinal degeneration (HP:0001146)3.34210084
34Hypokinesia (HP:0002375)3.33654022
35Muscle fibrillation (HP:0010546)3.27573701
36Bowed forearm bones (HP:0003956)3.26878507
37Bowing of the arm (HP:0006488)3.26878507
38Reduced subcutaneous adipose tissue (HP:0003758)3.09071508
39Menstrual irregularities (HP:0000858)3.07349710
40Polar cataract (HP:0010696)3.05288413
41Attenuation of retinal blood vessels (HP:0007843)3.02404185
42Septo-optic dysplasia (HP:0100842)3.00274922
43Metaphyseal cupping (HP:0003021)2.97937225
44Abnormality of lateral ventricle (HP:0030047)2.97183622
45Scotoma (HP:0000575)2.95220501
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94921663
47Distal lower limb muscle weakness (HP:0009053)2.94795822
48Chorioretinal atrophy (HP:0000533)2.87622919
49Increased connective tissue (HP:0009025)2.86273034
50Cupped ribs (HP:0000887)2.84636803
51Short nail (HP:0001799)2.82397257
52Menorrhagia (HP:0000132)2.81495652
53Microretrognathia (HP:0000308)2.79736669
54Limited elbow extension (HP:0001377)2.77990652
55Increased nuchal translucency (HP:0010880)2.77612763
56Decreased muscle mass (HP:0003199)2.77438466
57Short phalanx of the thumb (HP:0009660)2.74881696
58Reduced antithrombin III activity (HP:0001976)2.73390748
59Fragile skin (HP:0001030)2.69184701
60Proximal placement of thumb (HP:0009623)2.69126826
61Hypoplasia of the fovea (HP:0007750)2.68379013
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.68379013
63Abnormality of carpal bone ossification (HP:0006257)2.67921766
64Hemorrhage of the eye (HP:0011885)2.66698755
65Breast hypoplasia (HP:0003187)2.66489440
66Vertebral compression fractures (HP:0002953)2.64401027
67Type II diabetes mellitus (HP:0005978)2.62598637
68Spondylolisthesis (HP:0003302)2.60443125
69Spinal rigidity (HP:0003306)2.58106440
70Premature rupture of membranes (HP:0001788)2.57940343
71Coxa vara (HP:0002812)2.55779096
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55090672
73Partial duplication of thumb phalanx (HP:0009944)2.54068576
74Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.49702583
75Difficulty climbing stairs (HP:0003551)2.48177207
76Cervical subluxation (HP:0003308)2.48050992
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.45392715
78Partial duplication of the phalanx of hand (HP:0009999)2.44662980
79Hypoplastic ischia (HP:0003175)2.42590816
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.42397087
81Choroideremia (HP:0001139)2.42199318
82Subcapsular cataract (HP:0000523)2.41192097
83Abnormality of binocular vision (HP:0011514)2.39007089
84Diplopia (HP:0000651)2.39007089
85Ridged nail (HP:0001807)2.38524977
86Abnormal ossification of hand bones (HP:0005921)2.38119304
87Abnormality of the proximal phalanges of the hand (HP:0009834)2.37739952
88Alopecia of scalp (HP:0002293)2.37739409
89Urethral obstruction (HP:0000796)2.36872840
90Widely spaced teeth (HP:0000687)2.36762136
91Insomnia (HP:0100785)2.35800374
92Methylmalonic aciduria (HP:0012120)2.35794357
93Pendular nystagmus (HP:0012043)2.34812739
94Abnormality of the motor neurons (HP:0002450)2.32274745
95Abnormal neuron morphology (HP:0012757)2.32274745
96Truncal obesity (HP:0001956)2.30562862
97Abnormality of the phalanges of the hallux (HP:0010057)2.28486187
98Spinal cord compression (HP:0002176)2.28365990
99Deviation of the thumb (HP:0009603)2.27783003
10011 pairs of ribs (HP:0000878)2.26893798
101Hypoplastic pelvis (HP:0008839)2.26056327
102Congenital glaucoma (HP:0001087)2.26022151
103Abnormal vertebral ossification (HP:0100569)2.22883231
104Scanning speech (HP:0002168)2.22549300
105Diaphragmatic weakness (HP:0009113)2.21899433
106Generalized amyotrophy (HP:0003700)2.21770368
107Clumsiness (HP:0002312)2.17807673
108Vascular tortuosity (HP:0004948)2.17659450
109Abnormality of the fovea (HP:0000493)2.17386256
110Long eyelashes (HP:0000527)2.17211570
111Photophobia (HP:0000613)2.16752762
112Broad hallux (HP:0010055)2.16714090
113Prenatal maternal abnormality (HP:0002686)2.16635295
114Disproportionate tall stature (HP:0001519)2.15145200
115Patellar dislocation (HP:0002999)2.12421226
116Abnormality of the ischium (HP:0003174)2.12223184
117Abnormal protein glycosylation (HP:0012346)2.12207742
118Abnormal glycosylation (HP:0012345)2.12207742
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12207742
120Abnormal protein N-linked glycosylation (HP:0012347)2.12207742
121Abnormality of subcutaneous fat tissue (HP:0001001)2.10766299
122Potter facies (HP:0002009)2.09916030
123Facial shape deformation (HP:0011334)2.09916030
124Pterygium (HP:0001059)2.09339515
125Cerebellar dysplasia (HP:0007033)2.09021048
126Hyperacusis (HP:0010780)2.08497647
127Arterial tortuosity (HP:0005116)2.06012438
128Broad face (HP:0000283)2.05893579
129Delayed puberty (HP:0000823)2.05493388
130Decreased subcutaneous fat (HP:0001002)2.04586956
131Increased cerebral lipofuscin (HP:0011813)2.03223769
132Retinitis pigmentosa (HP:0000510)2.03208897
133Down-sloping shoulders (HP:0200021)2.01924613
134High anterior hairline (HP:0009890)2.01295960
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01215953
136Coronal craniosynostosis (HP:0004440)2.01156809
137Congenital stationary night blindness (HP:0007642)12.3084456
138Aortic aneurysm (HP:0004942)1.99265800
139Interstitial pulmonary disease (HP:0006530)1.98006557
140Type I transferrin isoform profile (HP:0003642)1.97888236
141Small epiphyses (HP:0010585)1.97635408
142Severe short stature (HP:0003510)1.95982651
143Aortic dissection (HP:0002647)1.95289642
144Trismus (HP:0000211)1.94314498
145Rapidly progressive (HP:0003678)1.93173391
146Neoplasm of the heart (HP:0100544)1.93099689
147Apathy (HP:0000741)1.93050307
148Tubular atrophy (HP:0000092)1.92221099
149Mildly elevated creatine phosphokinase (HP:0008180)1.91230906
150Osteomalacia (HP:0002749)1.90116891
151Hemiparesis (HP:0001269)1.89138002
152Large for gestational age (HP:0001520)1.88597207
153Partial agenesis of the corpus callosum (HP:0001338)1.87095449
154Enlarged kidneys (HP:0000105)1.87025419
155Fragile nails (HP:0001808)1.86695827
156Shallow orbits (HP:0000586)1.86216709
157Bulbar palsy (HP:0001283)1.84773527
158Abnormal hand bone ossification (HP:0010660)1.84577434
159Fused cervical vertebrae (HP:0002949)1.82556328
160Rhabdomyolysis (HP:0003201)1.82490364
161Obstructive sleep apnea (HP:0002870)1.80948847
162Glossoptosis (HP:0000162)1.79704282
163Congenital hip dislocation (HP:0001374)1.79110976
164Nail dystrophy (HP:0008404)1.78695363
165Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78583796
166Hypoventilation (HP:0002791)1.77611606
167Small hand (HP:0200055)1.77185598
168Prolonged bleeding time (HP:0003010)1.75120626
169Polydipsia (HP:0001959)1.74865926
170Abnormal drinking behavior (HP:0030082)1.74865926
171Split hand (HP:0001171)1.74148889
172Decreased circulating renin level (HP:0003351)1.71165137
173Acute hepatic failure (HP:0006554)1.68545085
174Fatigue (HP:0012378)1.66594344
175Sex reversal (HP:0012245)1.66563431
176Abnormal sex determination (HP:0012244)1.66563431
177Aplasia/Hypoplasia of the macula (HP:0008059)1.65962634
178Abnormal gallbladder physiology (HP:0012438)1.64342409
179Cholecystitis (HP:0001082)1.64342409
180Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63891187
181Back pain (HP:0003418)1.62044391
182Absent septum pellucidum (HP:0001331)1.60635183
183Narrow nasal bridge (HP:0000446)1.59326261
184Decreased testicular size (HP:0008734)1.58750943
185Obsessive-compulsive behavior (HP:0000722)1.58487248
186Lack of skin elasticity (HP:0100679)1.58077278
187Downturned corners of mouth (HP:0002714)1.57313498
188Hypoglycemic seizures (HP:0002173)1.56792521
189Tongue fasciculations (HP:0001308)1.56148483
190Cone-rod dystrophy (HP:0000548)1.55446805
191Aplasia/Hypoplasia of the nipples (HP:0006709)1.53995236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.91693025
2PBK6.90606135
3LMTK26.78915635
4PASK6.37940038
5MST1R5.49206939
6EPHB14.39769620
7MUSK3.61901597
8NME23.04107783
9FGFR22.88963576
10INSRR2.80474077
11IRAK32.80158425
12ERN12.63864999
13MET2.54800417
14FGFR42.46774656
15ERBB42.43190951
16IRAK22.35400872
17MARK12.15582257
18CDK82.15543575
19KSR12.14976848
20MAPK112.12030032
21PTK2B2.08413083
22CAMKK12.04988753
23UHMK11.92929039
24BCKDK1.90249726
25PAK61.89876752
26SIK31.86675102
27TRIB31.77075625
28WNK31.74760302
29ERBB21.64467496
30PHKG21.63197852
31PHKG11.63197852
32CCNB11.57633366
33PTK21.57416775
34VRK11.53546151
35TIE11.53058338
36PTK61.47595538
37PRKD21.34779110
38TYRO31.23831763
39NEK61.23450845
40BLK1.23442022
41EPHA31.22413598
42PAK41.20130112
43TTN1.03133048
44DYRK1B0.91694088
45MAPK150.91405110
46TESK10.90744728
47TESK20.89931807
48MAPK70.89538736
49IRAK10.88781737
50NTRK10.87556692
51MAP3K70.85817119
52NTRK20.85579410
53EIF2AK10.81482392
54RIPK10.81158552
55PRKCZ0.81091250
56FGFR30.78635702
57NEK10.77947750
58PDGFRA0.77504284
59MINK10.76668178
60MAP3K30.72711483
61EPHB20.71550234
62PRKCI0.71383555
63CDC42BPA0.70577756
64CSK0.70422453
65FGFR10.69071788
66PRPF4B0.68020271
67IRAK40.67913213
68WNK40.66396407
69PAK10.66058653
70MAP3K40.63860890
71ITK0.62895392
72ERBB30.62809047
73PAK30.61595940
74ROCK20.60601022
75BMX0.59807972
76DDR20.59462940
77LIMK10.58866477
78CDK90.58838886
79BCR0.55258858
80SCYL20.55114063
81SIK10.53014313
82EIF2AK20.50105226
83WNK10.50094542
84MTOR0.50065847
85PRKACG0.50008386
86PIK3CG0.49889437
87PRKD30.48999692
88BRSK10.48441672
89MAP3K90.46997501
90DYRK20.46995855
91ARAF0.45965643
92MAPK90.45963101
93PKN10.45340150
94ILK0.45156359
95EEF2K0.44955416
96SMG10.44843809
97CDK30.43965981
98GSK3A0.42830979
99MOS0.42407038
100PINK10.42020012
101RPS6KB20.41773939
102MAP3K110.41340914
103TGFBR20.40804144
104FGR0.40482291
105DYRK30.40204656
106PLK30.39061196
107LATS20.38896460
108FER0.38695222
109ICK0.38477898
110TAOK20.38421804
111GRK60.34137068
112PRKACA0.34116003
113GRK50.34104117
114LRRK20.33238378
115GRK10.32974769
116ADRBK10.32364012
117MAPK130.31481886
118CAMK10.31054187
119EIF2AK30.30596107
120YES10.30517609
121KIT0.28295618
122NTRK30.27488192
123DYRK1A0.25448905
124PKN20.24874937
125EPHA40.24617136
126STK380.23820932
127PRKD10.23112668
128TNIK0.21788463
129ROCK10.21610208
130CDK180.21437611
131FLT30.20539831
132LYN0.20357064
133CDK190.19766476
134DAPK10.19212575
135MAP3K100.17997337
136CSF1R0.17819301
137PRKCD0.17777503
138BTK0.17189903
139STK390.16955439
140PRKCA0.16514420
141PIM20.15951277
142CAMK2G0.15801711
143AKT20.15216670
144CHEK20.14900340
145STK100.14318608
146MAP2K10.13316747
147RPS6KA40.12870199
148MAP3K20.09890912
149PDPK10.09620099
150PRKAA10.08503710
151CAMK2B0.07425484
152AURKA0.05019181
153CDK50.02815817
154BUB10.02376537
155CAMK2D0.01386810
156DAPK20.00986609
157MAPK80.00109780
158MATK0.00100260
159RPS6KA2-0.0218660
160IGF1R-0.0070672
161AKT3-0.0053142
162CDK11A-0.0038195
163CDK14-0.0028175

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.99918736
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.19232782
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.23275274
4Selenocompound metabolism_Homo sapiens_hsa004502.82441868
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.76967936
6Pentose phosphate pathway_Homo sapiens_hsa000302.69868606
7Histidine metabolism_Homo sapiens_hsa003402.60633406
8GABAergic synapse_Homo sapiens_hsa047272.58760962
9Vitamin B6 metabolism_Homo sapiens_hsa007502.25495795
10Fructose and mannose metabolism_Homo sapiens_hsa000512.21205801
11Synaptic vesicle cycle_Homo sapiens_hsa047212.18021058
12Proteoglycans in cancer_Homo sapiens_hsa052052.00537180
13Sulfur relay system_Homo sapiens_hsa041221.93478741
14Focal adhesion_Homo sapiens_hsa045101.91002072
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.89781054
16Galactose metabolism_Homo sapiens_hsa000521.89609496
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.82957812
18Peroxisome_Homo sapiens_hsa041461.77475794
19Nicotine addiction_Homo sapiens_hsa050331.69783010
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63709246
21Basal cell carcinoma_Homo sapiens_hsa052171.58697656
22VEGF signaling pathway_Homo sapiens_hsa043701.53504441
23Insulin secretion_Homo sapiens_hsa049111.46344933
24Biosynthesis of amino acids_Homo sapiens_hsa012301.45675032
25Glucagon signaling pathway_Homo sapiens_hsa049221.45667054
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39448192
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39330953
28Arginine and proline metabolism_Homo sapiens_hsa003301.37255707
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.36782195
30Tryptophan metabolism_Homo sapiens_hsa003801.34663546
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32893601
32N-Glycan biosynthesis_Homo sapiens_hsa005101.29374686
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28520218
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28103853
35HTLV-I infection_Homo sapiens_hsa051661.24927865
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21348357
37Salivary secretion_Homo sapiens_hsa049701.21024144
38Vitamin digestion and absorption_Homo sapiens_hsa049771.14327255
39Cardiac muscle contraction_Homo sapiens_hsa042601.13140181
40Insulin resistance_Homo sapiens_hsa049311.12339832
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10919497
42Starch and sucrose metabolism_Homo sapiens_hsa005001.10445346
43Folate biosynthesis_Homo sapiens_hsa007901.08845601
44Pathways in cancer_Homo sapiens_hsa052001.08509833
45Dilated cardiomyopathy_Homo sapiens_hsa054141.07724082
46Insulin signaling pathway_Homo sapiens_hsa049101.05987637
47Renal cell carcinoma_Homo sapiens_hsa052111.05734131
48Small cell lung cancer_Homo sapiens_hsa052221.04370478
49African trypanosomiasis_Homo sapiens_hsa051431.03940340
50Calcium signaling pathway_Homo sapiens_hsa040200.99965695
51ECM-receptor interaction_Homo sapiens_hsa045120.99219462
52Cocaine addiction_Homo sapiens_hsa050300.99175231
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98598828
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94011100
55Inositol phosphate metabolism_Homo sapiens_hsa005620.93935477
56Morphine addiction_Homo sapiens_hsa050320.93031237
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.90172179
58Circadian entrainment_Homo sapiens_hsa047130.89492421
59Endocytosis_Homo sapiens_hsa041440.87476397
60Notch signaling pathway_Homo sapiens_hsa043300.87217837
61Adherens junction_Homo sapiens_hsa045200.86143190
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85126192
63TGF-beta signaling pathway_Homo sapiens_hsa043500.83510071
64Other glycan degradation_Homo sapiens_hsa005110.83086198
65Carbon metabolism_Homo sapiens_hsa012000.80431050
66ABC transporters_Homo sapiens_hsa020100.80362988
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78920589
68Serotonergic synapse_Homo sapiens_hsa047260.77925735
69Pyrimidine metabolism_Homo sapiens_hsa002400.77733476
70Fatty acid degradation_Homo sapiens_hsa000710.77223041
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.77094219
72AMPK signaling pathway_Homo sapiens_hsa041520.77048089
73ErbB signaling pathway_Homo sapiens_hsa040120.76942904
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76773793
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76448402
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76044086
77Lysine degradation_Homo sapiens_hsa003100.75461342
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75074481
79Glutathione metabolism_Homo sapiens_hsa004800.73936648
80Phenylalanine metabolism_Homo sapiens_hsa003600.73844426
81Alcoholism_Homo sapiens_hsa050340.72697535
82Axon guidance_Homo sapiens_hsa043600.72125932
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.71689381
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69248155
85Dopaminergic synapse_Homo sapiens_hsa047280.67772384
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66367739
87Gap junction_Homo sapiens_hsa045400.66079737
88Prion diseases_Homo sapiens_hsa050200.65582816
89Propanoate metabolism_Homo sapiens_hsa006400.65447592
90Oxytocin signaling pathway_Homo sapiens_hsa049210.65395239
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65111522
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64207475
93mTOR signaling pathway_Homo sapiens_hsa041500.63387529
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63075206
95RNA polymerase_Homo sapiens_hsa030200.61796509
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60980167
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60897837
98Protein digestion and absorption_Homo sapiens_hsa049740.60879225
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60161514
100Chemical carcinogenesis_Homo sapiens_hsa052040.59810915
101Purine metabolism_Homo sapiens_hsa002300.59795472
102Olfactory transduction_Homo sapiens_hsa047400.59251387
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58393894
104Glutamatergic synapse_Homo sapiens_hsa047240.58365655
105Renin secretion_Homo sapiens_hsa049240.57284962
106Wnt signaling pathway_Homo sapiens_hsa043100.57054499
107Colorectal cancer_Homo sapiens_hsa052100.56735107
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.56127285
109Cholinergic synapse_Homo sapiens_hsa047250.55385087
110Bile secretion_Homo sapiens_hsa049760.54651641
111Chronic myeloid leukemia_Homo sapiens_hsa052200.54599627
112Fatty acid metabolism_Homo sapiens_hsa012120.53819796
113Retinol metabolism_Homo sapiens_hsa008300.53541064
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53539696
115Sulfur metabolism_Homo sapiens_hsa009200.53260627
116Rap1 signaling pathway_Homo sapiens_hsa040150.52765223
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52324791
118Pancreatic cancer_Homo sapiens_hsa052120.52026448
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.51888815
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51249064
121Alzheimers disease_Homo sapiens_hsa050100.51051111
122HIF-1 signaling pathway_Homo sapiens_hsa040660.50695703
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48674360
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.48208173
125Glioma_Homo sapiens_hsa052140.46400277
126mRNA surveillance pathway_Homo sapiens_hsa030150.45859984
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45203941
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44939364
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.44784543
130Circadian rhythm_Homo sapiens_hsa047100.44503061
131Parkinsons disease_Homo sapiens_hsa050120.44134531
132Pancreatic secretion_Homo sapiens_hsa049720.43563662
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41116033
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40510973
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39890776
136Vibrio cholerae infection_Homo sapiens_hsa051100.39341816
137Phagosome_Homo sapiens_hsa041450.38711389
138Shigellosis_Homo sapiens_hsa051310.37400454
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37156787
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37104007
141Melanogenesis_Homo sapiens_hsa049160.36747660
142Sphingolipid metabolism_Homo sapiens_hsa006000.36663273
143Base excision repair_Homo sapiens_hsa034100.35265393
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35264041
145Spliceosome_Homo sapiens_hsa030400.35160408
146Fatty acid biosynthesis_Homo sapiens_hsa000610.34577268
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33664125
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33523486
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33316329
150Oxidative phosphorylation_Homo sapiens_hsa001900.33199516
151Thyroid cancer_Homo sapiens_hsa052160.32405770
152Platelet activation_Homo sapiens_hsa046110.32203825
153Viral myocarditis_Homo sapiens_hsa054160.31408850
154Huntingtons disease_Homo sapiens_hsa050160.31296964
155Hippo signaling pathway_Homo sapiens_hsa043900.30768199
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.30647455
157Melanoma_Homo sapiens_hsa052180.30619391
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30436940
159Bladder cancer_Homo sapiens_hsa052190.29081370
160Amoebiasis_Homo sapiens_hsa051460.28790096
161Tight junction_Homo sapiens_hsa045300.28775418

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