MSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.62561352
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.42983557
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.42983557
4antigen processing and presentation of endogenous antigen (GO:0019883)4.34084334
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24908483
6negative regulation of erythrocyte differentiation (GO:0045647)4.12761093
7leukocyte aggregation (GO:0070486)3.83415526
8regulation of B cell receptor signaling pathway (GO:0050855)3.75302067
9detection of other organism (GO:0098543)3.70914053
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64853721
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.64853721
12modulation by symbiont of host immune response (GO:0052553)3.64853721
13positive regulation by symbiont of host defense response (GO:0052509)3.64853721
14modulation by symbiont of host defense response (GO:0052031)3.64853721
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64853721
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51916341
17detection of bacterium (GO:0016045)3.50087696
18regulation of gamma-delta T cell differentiation (GO:0045586)3.41766580
19neutrophil activation involved in immune response (GO:0002283)3.40715223
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.36985405
21cellular extravasation (GO:0045123)3.35300693
22negative thymic T cell selection (GO:0045060)3.34620517
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.33057821
24positive thymic T cell selection (GO:0045059)3.32960404
25negative T cell selection (GO:0043383)3.28358252
26regulation of gamma-delta T cell activation (GO:0046643)3.25532377
27protein localization to endosome (GO:0036010)3.25049410
28negative regulation of cell killing (GO:0031342)3.19576640
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.19576640
30regulation of interferon-beta biosynthetic process (GO:0045357)3.14183063
31detection of external biotic stimulus (GO:0098581)3.13656471
32tolerance induction (GO:0002507)3.07432855
33regulation of B cell differentiation (GO:0045577)3.07360923
34cell adhesion mediated by integrin (GO:0033627)3.05305057
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03726629
36detection of molecule of bacterial origin (GO:0032490)3.02130173
37positive regulation of interferon-alpha production (GO:0032727)3.01176568
38regulation of leukocyte degranulation (GO:0043300)2.96992547
39regulation of T cell tolerance induction (GO:0002664)2.96963118
40regulation of mast cell degranulation (GO:0043304)2.96788102
41barbed-end actin filament capping (GO:0051016)2.95851753
42B cell receptor signaling pathway (GO:0050853)2.95460556
43lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95122153
44regulation of interferon-alpha production (GO:0032647)2.90974244
45immunoglobulin mediated immune response (GO:0016064)2.90582210
46T cell migration (GO:0072678)2.88025916
47* leukocyte cell-cell adhesion (GO:0007159)2.85135727
48response to muramyl dipeptide (GO:0032495)2.85099697
49negative regulation of T cell mediated immunity (GO:0002710)2.84881748
50germinal center formation (GO:0002467)2.84319069
51negative regulation of phagocytosis (GO:0050765)2.83919055
52positive regulation of B cell differentiation (GO:0045579)2.82364516
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82120714
54thymic T cell selection (GO:0045061)2.81207628
55negative regulation of lymphocyte mediated immunity (GO:0002707)2.80667748
56negative regulation of leukocyte mediated immunity (GO:0002704)2.80484195
57cellular response to zinc ion (GO:0071294)2.77880237
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77400753
59neutrophil activation (GO:0042119)2.77311631
60detection of biotic stimulus (GO:0009595)2.75870659
61hepatocyte apoptotic process (GO:0097284)2.75547526
62pinocytosis (GO:0006907)2.74844797
63positive regulation of lamellipodium assembly (GO:0010592)2.74789205
64response to laminar fluid shear stress (GO:0034616)2.74735444
65response to interleukin-15 (GO:0070672)2.74447531
66NIK/NF-kappaB signaling (GO:0038061)2.74298381
67positive regulation of natural killer cell differentiation (GO:0032825)2.72719529
68interferon-gamma-mediated signaling pathway (GO:0060333)2.70705511
69cellular response to interleukin-15 (GO:0071350)2.70493628
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69512190
71granulocyte activation (GO:0036230)2.68855327
72negative regulation of interleukin-12 production (GO:0032695)2.68688186
73regulation of mast cell activation involved in immune response (GO:0033006)2.67639007
74hypotonic response (GO:0006971)2.67255505
75JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66321797
76positive regulation of macrophage differentiation (GO:0045651)2.64358226
77regulation of necroptotic process (GO:0060544)2.61861003
78macrophage activation involved in immune response (GO:0002281)2.61554732
79substrate-dependent cell migration (GO:0006929)2.61405853
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60287470
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60089394
82morphogenesis of an endothelium (GO:0003159)2.59092956
83endothelial tube morphogenesis (GO:0061154)2.59092956
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59031344
85response to peptidoglycan (GO:0032494)2.58762490
86myeloid dendritic cell activation (GO:0001773)2.58756682
87stress fiber assembly (GO:0043149)2.58536418
88positive regulation of isotype switching (GO:0045830)2.57316459
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57017027
90response to type I interferon (GO:0034340)2.56913398
91regulation of macrophage cytokine production (GO:0010935)2.55059696
92T cell selection (GO:0045058)2.54331464
93actin nucleation (GO:0045010)2.53619908
94regulation of alpha-beta T cell proliferation (GO:0046640)2.53323449
95regulation of natural killer cell mediated immunity (GO:0002715)2.53269517
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53269517
97myeloid dendritic cell differentiation (GO:0043011)2.52639462
98heterotypic cell-cell adhesion (GO:0034113)2.51491748
99antigen processing and presentation via MHC class Ib (GO:0002475)2.51137042
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51084315
101T cell costimulation (GO:0031295)2.50859291
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50816128
103cellular response to type I interferon (GO:0071357)2.50616453
104type I interferon signaling pathway (GO:0060337)2.50616453
105regulation of tolerance induction (GO:0002643)2.49735523
106positive regulation of interferon-beta production (GO:0032728)2.49685296
107macrophage activation (GO:0042116)2.49091975
108interferon-gamma production (GO:0032609)2.47770538
109positive regulation of tolerance induction (GO:0002645)2.47346540
110positive T cell selection (GO:0043368)2.46169302
111positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.45877234
112natural killer cell differentiation (GO:0001779)2.45031079
113lymphocyte costimulation (GO:0031294)2.44754121
114positive regulation of lamellipodium organization (GO:1902745)2.43999712
115positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43597621
116angiogenesis involved in wound healing (GO:0060055)2.42937036
117germ cell migration (GO:0008354)2.42617925
118respiratory burst (GO:0045730)2.42118526
119defense response to protozoan (GO:0042832)2.41915688
120mannose metabolic process (GO:0006013)2.41612298
121B cell mediated immunity (GO:0019724)2.41473413
122negative regulation of B cell proliferation (GO:0030889)2.40794739
123megakaryocyte development (GO:0035855)2.39537623
124myeloid cell activation involved in immune response (GO:0002275)2.39410548
125regulation of defense response to virus by virus (GO:0050690)2.39354284
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.38641339
127response to host immune response (GO:0052572)2.38457396
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38457396
129membrane raft organization (GO:0031579)2.37547845
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37099806
131response to host (GO:0075136)2.37099806
132response to host defenses (GO:0052200)2.37099806
133regulation of response to interferon-gamma (GO:0060330)2.36241310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.14425093
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.30686073
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16655500
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.16472463
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.73212429
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.64380071
7E2F7_22180533_ChIP-Seq_HELA_Human3.45211623
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.23806051
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00962991
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78347862
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.78208585
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78084662
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72329492
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70764263
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65611792
16MYC_22102868_ChIP-Seq_BL_Human2.61292626
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47243566
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35303479
19MYB_26560356_Chip-Seq_TH2_Human2.34052090
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.33546770
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.26274314
22RUNX_20019798_ChIP-Seq_JUKART_Human2.25316021
23MAF_26560356_Chip-Seq_TH1_Human2.24557504
24VDR_21846776_ChIP-Seq_THP-1_Human2.21827514
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20983626
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06718849
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05106229
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.03382545
29MYB_26560356_Chip-Seq_TH1_Human1.95054589
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94191721
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92016984
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91745561
33SPI1_23547873_ChIP-Seq_NB4_Human1.91525589
34VDR_24763502_ChIP-Seq_THP-1_Human1.90641088
35* UTX_26944678_Chip-Seq_JUKART_Human1.87057631
36SCL_19346495_ChIP-Seq_HPC-7_Human1.85765380
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.84321050
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81113338
39TCF7_22412390_ChIP-Seq_EML_Mouse1.79767987
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76205208
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75568198
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73846948
43SPI1_23127762_ChIP-Seq_K562_Human1.70118114
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65186620
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61663303
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56167447
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51628629
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51197841
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48958251
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.48689763
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48293736
52KDM2B_26808549_Chip-Seq_DND41_Human1.48179049
53LXR_22292898_ChIP-Seq_THP-1_Human1.47583905
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45728488
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44302461
56PU_27001747_Chip-Seq_BMDM_Mouse1.44055330
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43001867
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.40596589
59GATA1_19941826_ChIP-Seq_K562_Human1.36930693
60GATA3_27048872_Chip-Seq_THYMUS_Human1.35516339
61CLOCK_20551151_ChIP-Seq_293T_Human1.35154918
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33881396
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.32207902
64* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29010259
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28775669
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27241923
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22133515
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22133515
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21277081
70MAF_26560356_Chip-Seq_TH2_Human1.20896365
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18093571
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16817404
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16664685
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11688212
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11326028
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.11023574
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10935806
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08981580
79RACK7_27058665_Chip-Seq_MCF-7_Human1.08421404
80VDR_24787735_ChIP-Seq_THP-1_Human1.08173254
81* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07701712
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06861165
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06665933
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04919188
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04741527
86TFEB_21752829_ChIP-Seq_HELA_Human1.04351732
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04336324
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03373866
89NCOR1_26117541_ChIP-Seq_K562_Human1.01895799
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01378367
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.01266159
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01188406
93* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01006037
94GATA2_19941826_ChIP-Seq_K562_Human1.00759861
95BRD4_25478319_ChIP-Seq_HGPS_Human1.00545064
96GATA1_22025678_ChIP-Seq_K562_Human0.97903542
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97267501
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95926823
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95143927
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93414541
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92640518
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91620640
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90854057
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90676949
105* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90346117
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.89131269
107GATA3_26560356_Chip-Seq_TH2_Human0.88861474
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88511636
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88376920
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88367273
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88126544
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87599042
113UBF1/2_26484160_Chip-Seq_HMECs_Human0.87382872
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86425309
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84281305
116* SMAD_19615063_ChIP-ChIP_OVARY_Human0.82391639
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82190083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.04896122
2MP0003303_peritoneal_inflammation2.80587151
3MP0003436_decreased_susceptibility_to2.70539392
4MP0000685_abnormal_immune_system2.64239980
5MP0003300_gastrointestinal_ulcer2.57823004
6MP0001790_abnormal_immune_system2.41939755
7MP0005387_immune_system_phenotype2.41939755
8MP0010352_gastrointestinal_tract_polyps2.38120942
9MP0005000_abnormal_immune_tolerance2.32519612
10MP0001800_abnormal_humoral_immune2.30162966
11MP0005671_abnormal_response_to2.25332489
12MP0009785_altered_susceptibility_to2.24787753
13MP0002452_abnormal_antigen_presenting2.22494874
14MP0003566_abnormal_cell_adhesion2.20915232
15MP0003191_abnormal_cellular_cholesterol2.19181257
16MP0002419_abnormal_innate_immunity2.10863486
17MP0008438_abnormal_cutaneous_collagen2.09332095
18MP0005025_abnormal_response_to2.01304525
19MP0002723_abnormal_immune_serum2.01024509
20MP0002420_abnormal_adaptive_immunity2.00887533
21MP0001819_abnormal_immune_cell1.99783873
22MP0002148_abnormal_hypersensitivity_rea1.97935949
23MP0003279_aneurysm1.95540014
24MP0005451_abnormal_body_composition1.92195738
25MP0004808_abnormal_hematopoietic_stem1.91249725
26MP0002396_abnormal_hematopoietic_system1.91214368
27MP0002166_altered_tumor_susceptibility1.91089753
28MP0009278_abnormal_bone_marrow1.90134014
29MP0003763_abnormal_thymus_physiology1.87754814
30MP0002405_respiratory_system_inflammati1.86210482
31MP0003724_increased_susceptibility_to1.84356856
32MP0006054_spinal_hemorrhage1.82976350
33MP0003705_abnormal_hypodermis_morpholog1.81201023
34MP0002398_abnormal_bone_marrow1.80454362
35MP0006082_CNS_inflammation1.80073980
36MP0004947_skin_inflammation1.74075574
37MP0008260_abnormal_autophagy1.73313827
38MP0001533_abnormal_skeleton_physiology1.70678934
39MP0005464_abnormal_platelet_physiology1.70350180
40MP0000858_altered_metastatic_potential1.66261307
41MP0003448_altered_tumor_morphology1.66061905
42MP0003091_abnormal_cell_migration1.65952244
43MP0000716_abnormal_immune_system1.64157145
44MP0002006_tumorigenesis1.63497596
45MP0009333_abnormal_splenocyte_physiolog1.62442738
46MP0005023_abnormal_wound_healing1.60872681
47MP0010155_abnormal_intestine_physiology1.58642388
48MP0001545_abnormal_hematopoietic_system1.58301127
49MP0005397_hematopoietic_system_phenotyp1.58301127
50MP0005076_abnormal_cell_differentiation1.55188044
51MP0004510_myositis1.52257624
52MP0001853_heart_inflammation1.51351348
53MP0002933_joint_inflammation1.50937058
54MP0000689_abnormal_spleen_morphology1.49925636
55MP0001958_emphysema1.49157663
56MP0002722_abnormal_immune_system1.48256897
57MP0001845_abnormal_inflammatory_respons1.41691034
58MP0000343_altered_response_to1.40883360
59MP0005058_abnormal_lysosome_morphology1.40354054
60MP0002429_abnormal_blood_cell1.39813734
61MP0002877_abnormal_melanocyte_morpholog1.37678836
62MP0000703_abnormal_thymus_morphology1.25621386
63MP0003950_abnormal_plasma_membrane1.24785254
64MP0003828_pulmonary_edema1.23528147
65MP0010307_abnormal_tumor_latency1.20895913
66MP0001879_abnormal_lymphatic_vessel1.20697914
67MP0002998_abnormal_bone_remodeling1.19838335
68MP0003045_fibrosis1.19536062
69MP0000465_gastrointestinal_hemorrhage1.19170793
70MP0000733_abnormal_muscle_development1.18282399
71MP0010368_abnormal_lymphatic_system1.17494854
72MP0000767_abnormal_smooth_muscle1.15872874
73MP0001873_stomach_inflammation1.13213784
74MP0004883_abnormal_blood_vessel1.12972738
75MP0000569_abnormal_digit_pigmentation1.10404869
76MP0003075_altered_response_to1.10071871
77MP0005275_abnormal_skin_tensile1.05134352
78MP0009840_abnormal_foam_cell1.04622701
79MP0005390_skeleton_phenotype1.03208785
80MP0000490_abnormal_crypts_of1.03197549
81MP0005623_abnormal_meninges_morphology1.02939258
82MP0001849_ear_inflammation1.01469579
83MP0003172_abnormal_lysosome_physiology0.98938178
84MP0001915_intracranial_hemorrhage0.98527698
85MP0001851_eye_inflammation0.96458394
86MP0000249_abnormal_blood_vessel0.94685386
87MP0008469_abnormal_protein_level0.93160989
88MP0003453_abnormal_keratinocyte_physiol0.89635113
89MP0002138_abnormal_hepatobiliary_system0.87442439
90MP0004272_abnormal_basement_membrane0.86832244
91MP0003656_abnormal_erythrocyte_physiolo0.85758402
92MP0008004_abnormal_stomach_pH0.84505215
93MP0002019_abnormal_tumor_incidence0.83424990
94MP0009763_increased_sensitivity_to0.82400325
95MP0003795_abnormal_bone_structure0.82161713
96MP0009764_decreased_sensitivity_to0.80822881
97MP0005409_darkened_coat_color0.80658609
98MP0000604_amyloidosis0.78479468
99MP0005165_increased_susceptibility_to0.77087707
100MP0001542_abnormal_bone_strength0.76716298
101MP0008007_abnormal_cellular_replicative0.76578488
102MP0001243_abnormal_dermal_layer0.76161929
103MP0001348_abnormal_lacrimal_gland0.74443638
104MP0000015_abnormal_ear_pigmentation0.73491762
105MP0005164_abnormal_response_to0.73440236
106MP0002925_abnormal_cardiovascular_devel0.71003524
107MP0002132_abnormal_respiratory_system0.70083185
108MP0002128_abnormal_blood_circulation0.69692536
109MP0004381_abnormal_hair_follicle0.68875201
110MP0001614_abnormal_blood_vessel0.68735170
111MP0005310_abnormal_salivary_gland0.68371196
112MP0005503_abnormal_tendon_morphology0.66763686
113MP0005621_abnormal_cell_physiology0.65820629
114MP0002060_abnormal_skin_morphology0.63902804
115MP0005257_abnormal_intraocular_pressure0.63658370
116MP0003866_abnormal_defecation0.62007457
117MP0005166_decreased_susceptibility_to0.61022006
118MP0010630_abnormal_cardiac_muscle0.59132870

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.22029783
2Recurrent abscess formation (HP:0002722)4.16125011
3Recurrent bacterial skin infections (HP:0005406)3.55339783
4Myositis (HP:0100614)3.27452591
5Elevated erythrocyte sedimentation rate (HP:0003565)3.25932695
6Recurrent fungal infections (HP:0002841)3.23150221
7Recurrent viral infections (HP:0004429)3.11965225
8Cellulitis (HP:0100658)3.10355230
9Interstitial pulmonary disease (HP:0006530)3.04307411
10Protrusio acetabuli (HP:0003179)3.03400235
11Hematochezia (HP:0002573)3.01516334
12Cerebral aneurysm (HP:0004944)3.00670126
13Osteolytic defects of the hand bones (HP:0009699)2.96085032
14Osteolytic defects of the phalanges of the hand (HP:0009771)2.96085032
15Increased density of long bones (HP:0006392)2.92066748
16Spontaneous hematomas (HP:0007420)2.87687529
17Aortic aneurysm (HP:0004942)2.83840433
18Mediastinal lymphadenopathy (HP:0100721)2.80431693
19Prolonged bleeding time (HP:0003010)2.76467187
20Autoimmune thrombocytopenia (HP:0001973)2.75775469
21Chronic otitis media (HP:0000389)2.73157212
22Increased IgE level (HP:0003212)2.70894267
23Premature rupture of membranes (HP:0001788)2.68666090
24Orchitis (HP:0100796)2.68335321
25Recurrent bronchitis (HP:0002837)2.63959154
26Abnormality of macrophages (HP:0004311)2.61935723
27Epistaxis (HP:0000421)2.61288205
28Peritonitis (HP:0002586)2.58458314
29Abnormality of T cell number (HP:0011839)2.57231514
30Abnormality of the nasal mucosa (HP:0000433)2.57175317
31T lymphocytopenia (HP:0005403)2.54652047
32Syringomyelia (HP:0003396)2.53143408
33Spinal cord lesions (HP:0100561)2.53143408
34Recurrent gram-negative bacterial infections (HP:0005420)2.52122041
35Aortic dissection (HP:0002647)2.51188662
36Recurrent skin infections (HP:0001581)2.50871893
37Dilatation of the ascending aorta (HP:0005111)2.47083342
38Pustule (HP:0200039)2.45890690
39Gastrointestinal infarctions (HP:0005244)2.45611186
40IgM deficiency (HP:0002850)2.41418706
41Spondylolisthesis (HP:0003302)2.40553110
42Nasal polyposis (HP:0100582)2.37380966
43Abnormal platelet volume (HP:0011876)2.36797543
44Arterial thrombosis (HP:0004420)2.33791197
45Vasculitis (HP:0002633)2.33175706
46Obstructive lung disease (HP:0006536)2.32082599
47Chronic obstructive pulmonary disease (HP:0006510)2.32082599
48Increased cerebral lipofuscin (HP:0011813)2.31170455
49Recurrent cutaneous fungal infections (HP:0011370)2.29352188
50Chronic mucocutaneous candidiasis (HP:0002728)2.29352188
51Cervical subluxation (HP:0003308)2.28657447
52Osteomyelitis (HP:0002754)2.28528584
53Abnormality of glycolipid metabolism (HP:0010969)2.28477250
54Abnormality of liposaccharide metabolism (HP:0010968)2.28477250
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.28477250
56Thrombocytosis (HP:0001894)2.28293878
57Optic neuritis (HP:0100653)2.24450039
58Retrobulbar optic neuritis (HP:0100654)2.24450039
59Meningitis (HP:0001287)2.24106556
60Vertebral compression fractures (HP:0002953)2.23827313
61Urticaria (HP:0001025)2.21595787
62Polycythemia (HP:0001901)2.20699106
63Abnormality of T cells (HP:0002843)2.19268524
64Agammaglobulinemia (HP:0004432)2.18030016
65Stomatitis (HP:0010280)2.16172619
66Petechiae (HP:0000967)2.15429127
67Increased mean platelet volume (HP:0011877)2.14903861
68Gingival bleeding (HP:0000225)2.14726116
69Emphysema (HP:0002097)2.13082023
70Inflammation of the large intestine (HP:0002037)2.12825120
71Leukocytosis (HP:0001974)2.11311550
72Gingivitis (HP:0000230)2.11214702
73Fatigue (HP:0012378)2.10746265
74Periodontitis (HP:0000704)2.10448713
75Gastrointestinal inflammation (HP:0004386)2.10435909
76Pulmonary infiltrates (HP:0002113)2.09910717
77Gastrointestinal stroma tumor (HP:0100723)2.09896675
78Abnormal platelet function (HP:0011869)2.09436908
79Impaired platelet aggregation (HP:0003540)2.09436908
80Verrucae (HP:0200043)2.09072810
81Papilloma (HP:0012740)2.09072810
82Persistence of primary teeth (HP:0006335)2.08277146
83Encephalitis (HP:0002383)2.08060762
84Increased connective tissue (HP:0009025)2.07633125
85Amyloidosis (HP:0011034)2.06772659
86Absent frontal sinuses (HP:0002688)2.06735383
87Granulocytopenia (HP:0001913)2.06608481
88Abnormal delayed hypersensitivity skin test (HP:0002963)2.06055709
89Myocardial infarction (HP:0001658)2.03102644
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.02955011
91Viral hepatitis (HP:0006562)2.01258557
92Keratoconjunctivitis sicca (HP:0001097)2.00077505
93Distal lower limb amyotrophy (HP:0008944)1.99343436
94Colitis (HP:0002583)1.98748326
95Lymphopenia (HP:0001888)1.98246634
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.96879317
97Abnormality of skeletal muscle fiber size (HP:0012084)1.95499121
98Mitral valve prolapse (HP:0001634)1.94848648
99Shallow orbits (HP:0000586)1.92080073
100Loss of speech (HP:0002371)1.90998636
101Abnormality of the peritoneum (HP:0002585)1.90700478
102Menorrhagia (HP:0000132)1.90639578
103Panhypogammaglobulinemia (HP:0003139)1.89661780
104Eosinophilia (HP:0001880)1.88645041
105Hypergammaglobulinemia (HP:0010702)1.87900874
106Vacuolated lymphocytes (HP:0001922)1.87444315
107Abnormality of the fingertips (HP:0001211)1.86053577
108Aneurysm (HP:0002617)1.84249838
109Ankle contracture (HP:0006466)1.84170999
110Chest pain (HP:0100749)1.84128154
111IgA deficiency (HP:0002720)1.83977361
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.83897455
113Disinhibition (HP:0000734)1.83744342
114Skin ulcer (HP:0200042)1.83685890
115Broad face (HP:0000283)1.83685708
116Camptodactyly of toe (HP:0001836)1.83665297
117Increased IgM level (HP:0003496)1.83366807
118Subacute progressive viral hepatitis (HP:0006572)1.82568477
119Abnormality of T cell physiology (HP:0011840)1.82359696
120Bicuspid aortic valve (HP:0001647)1.82024384
121Increased variability in muscle fiber diameter (HP:0003557)1.81837086
122Hypertensive crisis (HP:0100735)1.81774843
123Abnormality of oral frenula (HP:0000190)1.81572128
124Autoimmune hemolytic anemia (HP:0001890)1.78479280
125Purpura (HP:0000979)1.78146192
126Ulnar bowing (HP:0003031)1.77575544
127Hemoptysis (HP:0002105)1.77484032
128Vascular tortuosity (HP:0004948)1.76225653
129Glomerulopathy (HP:0100820)1.75697655
130Acrocyanosis (HP:0001063)1.75090981
131Arterial tortuosity (HP:0005116)1.73612930
132Mucosal telangiectasiae (HP:0100579)1.71752311
133Dysostosis multiplex (HP:0000943)1.71427840
134Restrictive lung disease (HP:0002091)1.70130997
135Radial bowing (HP:0002986)1.69298008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.70272668
2PRPF4B3.62443159
3TRIB32.57988246
4JAK32.52902919
5TTN2.48021029
6TYK22.33924136
7MAP3K102.21382640
8ERN12.20985421
9MAP3K142.16098915
10TGFBR22.13044631
11TBK12.11014968
12TXK2.10279697
13ZAP702.04728826
14BLK1.98225711
15PKN21.91429996
16RPS6KA41.88764600
17* STK101.85597231
18KIT1.84344873
19JAK11.71626118
20ITK1.69180799
21EEF2K1.64535212
22SMG11.63786470
23CSK1.61392605
24KDR1.58584945
25EPHB11.50685098
26PIM21.49031860
27IRAK41.48674721
28BTK1.46259957
29CDK121.42895159
30FGFR31.41642173
31FGFR41.41124684
32IKBKE1.39335629
33PTK61.39249139
34TEC1.35478610
35HCK1.30247247
36IKBKB1.29609167
37CSF1R1.27420965
38TRPM71.27398951
39MAP2K31.25977780
40TAOK21.22325079
41NEK91.21187359
42KSR21.20627818
43TGFBR11.19630129
44RIPK11.17591586
45STK31.17515396
46LCK1.14510180
47* LRRK21.12985118
48MARK31.08782087
49MAP3K11.08689831
50FLT31.08601220
51SYK1.08480241
52CDK61.08397240
53PIM11.07713398
54TESK11.06912134
55GRK61.06037622
56CHUK1.06004032
57TESK21.04097544
58DMPK1.02298359
59PAK41.00358974
60ICK0.99355911
61CDC42BPA0.92768526
62MAP3K130.91233196
63BMPR20.91083774
64PRKD20.90814234
65RIPK40.90764737
66IRAK30.88464968
67CLK10.86229088
68PDGFRA0.86155285
69SIK10.85267999
70MARK20.85052533
71EPHA30.84956883
72MAP3K60.79613944
73NLK0.79418056
74YES10.78008520
75BMX0.77766663
76LYN0.77646689
77STK240.76171382
78PDGFRB0.76096130
79TAOK10.74440698
80PIK3CG0.73595360
81PTK20.70134368
82NME20.68927889
83TNK20.66914807
84STK40.66555006
85MAPK70.65967533
86MAPKAPK20.65423800
87CDK40.64916601
88JAK20.63616410
89PAK20.63447882
90PDPK10.62628832
91MAPK120.62537613
92MAP3K30.62349015
93MATK0.61696532
94HIPK20.61532905
95PDK10.60913219
96DDR20.57444547
97EGFR0.57303951
98MAP3K50.55099732
99MAP3K70.55038604
100NEK20.54138165
101PRKCH0.54113152
102MST40.52613025
103MAPK110.51290294
104RET0.51282925
105IRAK10.50961211
106ALK0.50910349
107MELK0.50373244
108MOS0.50345496
109CAMK1D0.50157097
110PRKG20.49767877
111ILK0.49062653
112RAF10.46128526
113FES0.45978247
114TIE10.45976147
115STK380.45755432
116FYN0.45347915
117MTOR0.45196551
118ABL10.45168302
119INSR0.44791649
120SCYL20.44633532
121TAOK30.42037584
122IGF1R0.38935094
123RPS6KB20.38715044
124* MAP3K80.38150138
125MAP3K110.35409488
126SIK30.35207882
127FGFR10.35161320
128SIK20.34933155
129PTK2B0.34357758
130FGR0.33490555
131BRSK20.32904176

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.64735824
2Primary immunodeficiency_Homo sapiens_hsa053402.31508984
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.19261674
4Osteoclast differentiation_Homo sapiens_hsa043802.15259316
5B cell receptor signaling pathway_Homo sapiens_hsa046622.06273766
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95005273
7Antigen processing and presentation_Homo sapiens_hsa046121.93089493
8* Measles_Homo sapiens_hsa051621.89728323
9Viral myocarditis_Homo sapiens_hsa054161.86502290
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85679997
11Shigellosis_Homo sapiens_hsa051311.80362586
12Toxoplasmosis_Homo sapiens_hsa051451.77502336
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76558230
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76353585
15Malaria_Homo sapiens_hsa051441.71459015
16Hematopoietic cell lineage_Homo sapiens_hsa046401.69946878
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69469485
18* Leukocyte transendothelial migration_Homo sapiens_hsa046701.67565898
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.67512439
20Graft-versus-host disease_Homo sapiens_hsa053321.60949383
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59531154
22Chronic myeloid leukemia_Homo sapiens_hsa052201.58855863
23TNF signaling pathway_Homo sapiens_hsa046681.57617948
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57501204
25T cell receptor signaling pathway_Homo sapiens_hsa046601.56353683
26Legionellosis_Homo sapiens_hsa051341.54739842
27Pertussis_Homo sapiens_hsa051331.51188396
28Apoptosis_Homo sapiens_hsa042101.51023124
29Tuberculosis_Homo sapiens_hsa051521.48095441
30Small cell lung cancer_Homo sapiens_hsa052221.46983395
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44450061
32Allograft rejection_Homo sapiens_hsa053301.44179608
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.41506976
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41084953
35Hepatitis B_Homo sapiens_hsa051611.40719208
36Pancreatic cancer_Homo sapiens_hsa052121.36417877
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36337887
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34851692
39Herpes simplex infection_Homo sapiens_hsa051681.33547248
40Salmonella infection_Homo sapiens_hsa051321.32293914
41Acute myeloid leukemia_Homo sapiens_hsa052211.27576856
42Staphylococcus aureus infection_Homo sapiens_hsa051501.27070505
43Influenza A_Homo sapiens_hsa051641.26421429
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26404149
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26178272
46Platelet activation_Homo sapiens_hsa046111.23094130
47Focal adhesion_Homo sapiens_hsa045101.22749083
48Chemokine signaling pathway_Homo sapiens_hsa040621.22256309
49Adherens junction_Homo sapiens_hsa045201.20590305
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12807108
51* Proteoglycans in cancer_Homo sapiens_hsa052051.11867123
52Amoebiasis_Homo sapiens_hsa051461.07478923
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06698019
54MicroRNAs in cancer_Homo sapiens_hsa052061.06507698
55Viral carcinogenesis_Homo sapiens_hsa052031.05596138
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.05473197
57HTLV-I infection_Homo sapiens_hsa051661.03924871
58p53 signaling pathway_Homo sapiens_hsa041151.02486384
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.01969692
60ECM-receptor interaction_Homo sapiens_hsa045121.01426652
61Lysosome_Homo sapiens_hsa041421.01322833
62Asthma_Homo sapiens_hsa053100.96526811
63* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95783692
64Epstein-Barr virus infection_Homo sapiens_hsa051690.95357273
65Colorectal cancer_Homo sapiens_hsa052100.89486685
66Phagosome_Homo sapiens_hsa041450.89429368
67VEGF signaling pathway_Homo sapiens_hsa043700.86312942
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86277285
69Hepatitis C_Homo sapiens_hsa051600.86266633
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.80731638
71Rheumatoid arthritis_Homo sapiens_hsa053230.79446802
72Autoimmune thyroid disease_Homo sapiens_hsa053200.79177811
73Other glycan degradation_Homo sapiens_hsa005110.76986188
74HIF-1 signaling pathway_Homo sapiens_hsa040660.73611376
75Non-small cell lung cancer_Homo sapiens_hsa052230.73049886
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.72901107
77Prolactin signaling pathway_Homo sapiens_hsa049170.70415661
78Prostate cancer_Homo sapiens_hsa052150.69127940
79Endocytosis_Homo sapiens_hsa041440.67263311
80Notch signaling pathway_Homo sapiens_hsa043300.66596976
81ErbB signaling pathway_Homo sapiens_hsa040120.65617456
82Renal cell carcinoma_Homo sapiens_hsa052110.64341130
83Pathways in cancer_Homo sapiens_hsa052000.63595083
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62677320
85Bladder cancer_Homo sapiens_hsa052190.62247073
86GnRH signaling pathway_Homo sapiens_hsa049120.61155066
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60060334
88Prion diseases_Homo sapiens_hsa050200.59961812
89Dorso-ventral axis formation_Homo sapiens_hsa043200.58685103
90Rap1 signaling pathway_Homo sapiens_hsa040150.58540286
91FoxO signaling pathway_Homo sapiens_hsa040680.58070026
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57402374
93Cell cycle_Homo sapiens_hsa041100.56465828
94Choline metabolism in cancer_Homo sapiens_hsa052310.55742861
95TGF-beta signaling pathway_Homo sapiens_hsa043500.55741020
96Endometrial cancer_Homo sapiens_hsa052130.53573456
97African trypanosomiasis_Homo sapiens_hsa051430.53366551
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52761070
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52630419
100Inositol phosphate metabolism_Homo sapiens_hsa005620.52509097
101Type I diabetes mellitus_Homo sapiens_hsa049400.51838398
102Glioma_Homo sapiens_hsa052140.51836896
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51597297
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.50665525
105mTOR signaling pathway_Homo sapiens_hsa041500.48375044
106Thyroid cancer_Homo sapiens_hsa052160.47791084
107Insulin resistance_Homo sapiens_hsa049310.44551940
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44007511
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.41506095
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40691808
111Dilated cardiomyopathy_Homo sapiens_hsa054140.40357133
112MAPK signaling pathway_Homo sapiens_hsa040100.40209549

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