MSNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.41924688
2cytidine deamination (GO:0009972)8.23811794
3cytidine metabolic process (GO:0046087)8.23811794
4cytidine catabolic process (GO:0006216)8.23811794
5DNA deamination (GO:0045006)7.97200838
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.16703196
7Arp2/3 complex-mediated actin nucleation (GO:0034314)6.17663697
8negative regulation of T cell apoptotic process (GO:0070233)5.42581266
9actin nucleation (GO:0045010)5.39130610
10cellular response to interleukin-15 (GO:0071350)5.31906682
11T cell migration (GO:0072678)5.25603290
12negative regulation by host of viral transcription (GO:0043922)4.69147721
13positive regulation of interleukin-8 secretion (GO:2000484)4.52146790
14positive regulation of defense response to virus by host (GO:0002230)4.44282644
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.41048050
16positive regulation of T cell mediated cytotoxicity (GO:0001916)4.36404686
17proteasome assembly (GO:0043248)4.36278278
18positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.35163789
19regulation of activation of Janus kinase activity (GO:0010533)4.27708586
20platelet dense granule organization (GO:0060155)4.26484309
21regulation of interleukin-8 secretion (GO:2000482)4.16999050
22positive regulation of natural killer cell mediated immunity (GO:0002717)4.16405223
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15054482
24positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.07796907
25response to interleukin-15 (GO:0070672)4.04048254
26negative regulation of viral genome replication (GO:0045071)4.03529587
27regulation of memory T cell differentiation (GO:0043380)3.99749258
28immunoglobulin mediated immune response (GO:0016064)3.99242296
29regulation of leukocyte mediated cytotoxicity (GO:0001910)3.91002411
30regulation of T cell tolerance induction (GO:0002664)3.87233387
31negative regulation of lymphocyte apoptotic process (GO:0070229)3.84807778
32regulation of T cell mediated cytotoxicity (GO:0001914)3.80241602
33pyrimidine nucleoside catabolic process (GO:0046135)3.78006766
34lymphocyte chemotaxis (GO:0048247)3.77242182
35regulation of interleukin-2 biosynthetic process (GO:0045076)3.75788818
36positive regulation of cell killing (GO:0031343)3.65544178
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.61628446
38regulation of natural killer cell mediated immunity (GO:0002715)3.61628446
39eosinophil chemotaxis (GO:0048245)3.60742432
40cytolysis (GO:0019835)3.59095782
41regulation of B cell differentiation (GO:0045577)3.55480943
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53925231
43negative regulation of calcium ion transport into cytosol (GO:0010523)3.53031377
44positive regulation of calcium-mediated signaling (GO:0050850)3.52829517
45negative regulation of stress fiber assembly (GO:0051497)3.47727249
46activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.47399193
47regulation of B cell receptor signaling pathway (GO:0050855)3.45780929
48regulation of chronic inflammatory response (GO:0002676)3.41012607
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.40817587
50lymphocyte migration (GO:0072676)3.38513340
51B cell mediated immunity (GO:0019724)3.35133845
52positive regulation of B cell differentiation (GO:0045579)3.33484120
53positive regulation of interleukin-17 production (GO:0032740)3.30530537
54positive regulation of tolerance induction (GO:0002645)3.29697459
55regulation of cell killing (GO:0031341)3.27732956
56regulation of T cell apoptotic process (GO:0070232)3.25111802
57eosinophil migration (GO:0072677)3.24665720
58negative regulation of leukocyte apoptotic process (GO:2000107)3.22297240
59regulation of T cell receptor signaling pathway (GO:0050856)3.15351680
60negative regulation of thymocyte apoptotic process (GO:0070244)3.15247004
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15145448
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14164286
63positive regulation of monocyte chemotaxis (GO:0090026)3.13004331
64response to interferon-beta (GO:0035456)3.10830120
65negative T cell selection (GO:0043383)3.09486208
66regulation of defense response to virus by host (GO:0050691)3.07979220
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07864640
68regulation of cellular amino acid metabolic process (GO:0006521)3.07375273
69regulation of alpha-beta T cell proliferation (GO:0046640)3.06536754
70signal complex assembly (GO:0007172)3.04787605
71negative thymic T cell selection (GO:0045060)3.04071992
72positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.04038717
73thymic T cell selection (GO:0045061)3.01853140
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00122787
75regulation of viral genome replication (GO:0045069)2.97843186
76regulation of tolerance induction (GO:0002643)2.97692237
77regulation of lymphocyte chemotaxis (GO:1901623)2.96922031
78macrophage chemotaxis (GO:0048246)2.94072171
79positive regulation of interferon-gamma production (GO:0032729)2.93303163
80natural killer cell activation (GO:0030101)2.92759859
81negative regulation of nitric-oxide synthase activity (GO:0051001)2.92435291
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90858771
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90858771
84protein deneddylation (GO:0000338)2.90428741
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89434223
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.87168107
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85968898
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85968898
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85968898
90regulation of calcium-mediated signaling (GO:0050848)2.83798735
91positive regulation of macrophage differentiation (GO:0045651)2.82270951
92positive regulation of T-helper 1 type immune response (GO:0002827)2.82257462
93regulation of isotype switching to IgG isotypes (GO:0048302)2.81976567
94regulation of gamma-delta T cell differentiation (GO:0045586)2.81413013
95positive regulation of lymphocyte mediated immunity (GO:0002708)2.81081950
96positive regulation of T cell mediated immunity (GO:0002711)2.80537076
97T cell costimulation (GO:0031295)2.77879550
98antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.76878853
99lymphocyte costimulation (GO:0031294)2.74022706
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71327342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.06999151
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.42458207
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.36476663
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30334971
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80310872
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.55047924
7VDR_22108803_ChIP-Seq_LS180_Human3.51477138
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.34288046
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.25118466
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.00399826
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85186681
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.82090244
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.79603669
14MYB_26560356_Chip-Seq_TH2_Human2.75895085
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.70272596
16RUNX_20019798_ChIP-Seq_JUKART_Human2.53478639
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50419217
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45857275
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43995422
20VDR_23849224_ChIP-Seq_CD4+_Human2.35358212
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24672822
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05949041
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03448624
24GATA3_26560356_Chip-Seq_TH2_Human2.02984831
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94528467
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.86175897
27GATA3_27048872_Chip-Seq_THYMUS_Human1.76704180
28UTX_26944678_Chip-Seq_JUKART_Human1.75887828
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.75882843
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73221120
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72838577
32MYB_26560356_Chip-Seq_TH1_Human1.71582720
33SPI1_23547873_ChIP-Seq_NB4_Human1.68632417
34GATA1_22025678_ChIP-Seq_K562_Human1.61995243
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59761633
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57544601
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55821733
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.51911943
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50699887
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42763202
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40994503
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39474548
43MAF_26560356_Chip-Seq_TH1_Human1.38043588
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37206274
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31703220
46BCL6_27268052_Chip-Seq_Bcells_Human1.28812196
47FOXP3_21729870_ChIP-Seq_TREG_Human1.28064086
48IRF1_19129219_ChIP-ChIP_H3396_Human1.27561148
49MAF_26560356_Chip-Seq_TH2_Human1.24593274
50FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21374858
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20495192
52HTT_18923047_ChIP-ChIP_STHdh_Human1.17991365
53AR_20517297_ChIP-Seq_VCAP_Human1.16736704
54ELK1_19687146_ChIP-ChIP_HELA_Human1.15419417
55TP53_22573176_ChIP-Seq_HFKS_Human1.14796555
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14754811
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12227562
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.10890801
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08477268
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06500239
61TAF2_19829295_ChIP-Seq_ESCs_Human1.05580062
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04149064
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01818802
64P300_27268052_Chip-Seq_Bcells_Human1.01471268
65CIITA_25753668_ChIP-Seq_RAJI_Human1.00510534
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00341889
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00022366
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99912241
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99701629
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99299526
71GATA3_26560356_Chip-Seq_TH1_Human0.98207638
72NANOG_20526341_ChIP-Seq_ESCs_Human0.97292948
73P53_21459846_ChIP-Seq_SAOS-2_Human0.95841289
74IRF8_27001747_Chip-Seq_BMDM_Mouse0.94131946
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93294287
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93023344
77SPI1_23127762_ChIP-Seq_K562_Human0.92671833
78CTCF_20526341_ChIP-Seq_ESCs_Human0.91285013
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91255790
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90128812
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88950966
82MYC_19829295_ChIP-Seq_ESCs_Human0.88944105
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88197513
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85607215
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84010148
86E2F1_20622854_ChIP-Seq_HELA_Human0.83892979
87ZNF274_21170338_ChIP-Seq_K562_Hela0.83383875
88DCP1A_22483619_ChIP-Seq_HELA_Human0.82599683
89ERG_20517297_ChIP-Seq_VCAP_Human0.82443199
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.81901800
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.81526878
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81136467
93BCOR_27268052_Chip-Seq_Bcells_Human0.81104157
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80924306
95RAC3_21632823_ChIP-Seq_H3396_Human0.80545142
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.80351318
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.80299479
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79137104
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77515529
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77431093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.54694583
2MP0009785_altered_susceptibility_to4.51217271
3MP0003950_abnormal_plasma_membrane3.93800615
4MP0001835_abnormal_antigen_presentation3.51949417
5MP0009333_abnormal_splenocyte_physiolog3.10906360
6MP0005000_abnormal_immune_tolerance2.77300287
7MP0002148_abnormal_hypersensitivity_rea2.67859660
8MP0005025_abnormal_response_to2.62463079
9MP0005464_abnormal_platelet_physiology2.58284368
10MP0003763_abnormal_thymus_physiology2.55547118
11MP0003436_decreased_susceptibility_to2.48947548
12MP0002166_altered_tumor_susceptibility2.39746637
13MP0002006_tumorigenesis2.27487878
14MP0002723_abnormal_immune_serum2.26758760
15MP0002132_abnormal_respiratory_system2.22936411
16MP0002420_abnormal_adaptive_immunity2.22654524
17MP0001800_abnormal_humoral_immune2.21552668
18MP0003866_abnormal_defecation2.16304622
19MP0005387_immune_system_phenotype2.15235790
20MP0001790_abnormal_immune_system2.15235790
21MP0001819_abnormal_immune_cell2.15167230
22MP0003045_fibrosis2.08122828
23MP0001661_extended_life_span2.06461281
24MP0001542_abnormal_bone_strength1.82192757
25MP0010155_abnormal_intestine_physiology1.81762408
26MP0002452_abnormal_antigen_presenting1.81113892
27MP0006082_CNS_inflammation1.78536861
28MP0009764_decreased_sensitivity_to1.72530794
29MP0003448_altered_tumor_morphology1.72037259
30MP0002398_abnormal_bone_marrow1.71000230
31MP0000569_abnormal_digit_pigmentation1.66851293
32MP0001905_abnormal_dopamine_level1.62020400
33MP0002419_abnormal_innate_immunity1.61106889
34MP0000716_abnormal_immune_system1.60616864
35MP0000685_abnormal_immune_system1.59723526
36MP0001845_abnormal_inflammatory_respons1.51136151
37MP0003646_muscle_fatigue1.49692251
38MP0004947_skin_inflammation1.43202381
39MP0002722_abnormal_immune_system1.42812081
40MP0000689_abnormal_spleen_morphology1.39456835
41MP0000703_abnormal_thymus_morphology1.37666373
42MP0005645_abnormal_hypothalamus_physiol1.31754993
43MP0006072_abnormal_retinal_apoptosis1.31425093
44MP0005377_hearing/vestibular/ear_phenot1.30999339
45MP0003878_abnormal_ear_physiology1.30999339
46MP0002429_abnormal_blood_cell1.30488422
47MP0002876_abnormal_thyroid_physiology1.28977137
48MP0002405_respiratory_system_inflammati1.27827260
49MP0001533_abnormal_skeleton_physiology1.20813840
50MP0006036_abnormal_mitochondrial_physio1.20562182
51MP0002102_abnormal_ear_morphology1.18358408
52MP0008469_abnormal_protein_level1.18105659
53MP0005646_abnormal_pituitary_gland1.16956697
54MP0004134_abnormal_chest_morphology1.16410135
55MP0002736_abnormal_nociception_after1.15209477
56MP0009763_increased_sensitivity_to1.13621693
57MP0005165_increased_susceptibility_to1.13604580
58MP0003075_altered_response_to1.11301247
59MP0000372_irregular_coat_pigmentation1.07598238
60MP0000343_altered_response_to1.07479497
61MP0002095_abnormal_skin_pigmentation1.06039186
62MP0001243_abnormal_dermal_layer1.03220005
63MP0010386_abnormal_urinary_bladder1.02658293
64MP0001764_abnormal_homeostasis1.01510918
65MP0008872_abnormal_physiological_respon0.99157026
66MP0010368_abnormal_lymphatic_system0.97568056
67MP0002933_joint_inflammation0.96401259
68MP0000858_altered_metastatic_potential0.96042630
69MP0009765_abnormal_xenobiotic_induced0.94534563
70MP0005083_abnormal_biliary_tract0.92801785
71MP0008775_abnormal_heart_ventricle0.85511835
72MP0005166_decreased_susceptibility_to0.84106804
73MP0001853_heart_inflammation0.82456452
74MP0003693_abnormal_embryo_hatching0.81593912
75MP0005410_abnormal_fertilization0.79153815
76MP0009053_abnormal_anal_canal0.77248126
77MP0000537_abnormal_urethra_morphology0.76797431
78MP0001765_abnormal_ion_homeostasis0.75453653
79MP0004145_abnormal_muscle_electrophysio0.74749598
80MP0002019_abnormal_tumor_incidence0.72928525
81MP0008961_abnormal_basal_metabolism0.72702531
82MP0002822_catalepsy0.71218467
83MP0002163_abnormal_gland_morphology0.69417510
84MP0008438_abnormal_cutaneous_collagen0.68840293
85MP0003656_abnormal_erythrocyte_physiolo0.67151892
86MP0002277_abnormal_respiratory_mucosa0.66916210
87MP0000749_muscle_degeneration0.65955376
88MP0003638_abnormal_response/metabolism_0.65223740
89MP0005670_abnormal_white_adipose0.63951020
90MP0001879_abnormal_lymphatic_vessel0.63822303
91MP0003279_aneurysm0.63549460
92MP0002168_other_aberrant_phenotype0.62356476
93MP0005390_skeleton_phenotype0.61957940
94MP0004147_increased_porphyrin_level0.60666161
95MP0005584_abnormal_enzyme/coenzyme_acti0.60575037
96MP0006054_spinal_hemorrhage0.59508721
97MP0000647_abnormal_sebaceous_gland0.57481107
98MP0005408_hypopigmentation0.55886187
99MP0001188_hyperpigmentation0.54714835
100MP0002138_abnormal_hepatobiliary_system0.53344757

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)7.49153175
2T lymphocytopenia (HP:0005403)5.69207810
3Abnormality of T cell number (HP:0011839)5.21352156
4IgG deficiency (HP:0004315)4.52646680
5Increased IgM level (HP:0003496)4.32630857
6Abnormality of T cells (HP:0002843)3.90635487
7Hepatocellular necrosis (HP:0001404)3.90314051
8Severe combined immunodeficiency (HP:0004430)3.70600700
9Congenital, generalized hypertrichosis (HP:0004540)3.38446690
10Hypoproteinemia (HP:0003075)3.36113123
11Hepatic necrosis (HP:0002605)3.17213580
12Mitochondrial inheritance (HP:0001427)3.13703319
13Abnormality of eosinophils (HP:0001879)3.13631998
14Elevated erythrocyte sedimentation rate (HP:0003565)3.13286269
15Abnormality of macrophages (HP:0004311)3.10487440
16Acute necrotizing encephalopathy (HP:0006965)3.09776941
17Thyroiditis (HP:0100646)3.09463685
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.07328536
19Chronic mucocutaneous candidiasis (HP:0002728)3.05646814
20Recurrent cutaneous fungal infections (HP:0011370)3.05646814
21Abnormal mitochondria in muscle tissue (HP:0008316)3.00303811
22Autoimmune hemolytic anemia (HP:0001890)2.99140917
23Petechiae (HP:0000967)2.99022408
24Oral leukoplakia (HP:0002745)2.93537717
25Stomatitis (HP:0010280)2.79439164
26Renal Fanconi syndrome (HP:0001994)2.73550134
27Combined immunodeficiency (HP:0005387)2.73259782
28Generalized aminoaciduria (HP:0002909)2.72243527
29Encephalitis (HP:0002383)2.71893384
30Increased CSF lactate (HP:0002490)2.71547644
31IgA deficiency (HP:0002720)2.64867208
32Type I transferrin isoform profile (HP:0003642)2.64409922
33Eosinophilia (HP:0001880)2.63647772
34Myositis (HP:0100614)2.62914063
35Abnormality of T cell physiology (HP:0011840)2.59671808
36Chronic diarrhea (HP:0002028)2.55502684
37Short middle phalanx of the 5th finger (HP:0004220)2.54642414
38Ulnar deviation of the wrist (HP:0003049)2.52187952
39Pancytopenia (HP:0001876)2.45243987
40Pustule (HP:0200039)2.43662428
41Impaired platelet aggregation (HP:0003540)2.41937694
42Abnormal platelet function (HP:0011869)2.41937694
43Recurrent fungal infections (HP:0002841)2.41758070
44Progressive macrocephaly (HP:0004481)2.37153630
45Nonimmune hydrops fetalis (HP:0001790)2.36593669
46Short tibia (HP:0005736)2.34869338
47Leukocytosis (HP:0001974)2.28719523
48Autoimmune thrombocytopenia (HP:0001973)2.28233692
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25420008
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24856835
51Acute encephalopathy (HP:0006846)2.22844762
52Abnormality of lateral ventricle (HP:0030047)2.19961932
53Pulmonary infiltrates (HP:0002113)2.19436334
54Sparse eyelashes (HP:0000653)2.15613209
55Granulocytopenia (HP:0001913)2.15434585
56Rough bone trabeculation (HP:0100670)2.14708921
573-Methylglutaconic aciduria (HP:0003535)2.11309362
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.10521778
59Hypergammaglobulinemia (HP:0010702)2.09148753
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07307907
61Abnormal protein N-linked glycosylation (HP:0012347)2.07307907
62Abnormal protein glycosylation (HP:0012346)2.07307907
63Abnormal glycosylation (HP:0012345)2.07307907
64Optic neuritis (HP:0100653)2.03109202
65Retrobulbar optic neuritis (HP:0100654)2.03109202
66IgM deficiency (HP:0002850)2.02111639
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.01472605
68Conical tooth (HP:0000698)2.00426141
69Thick nail (HP:0001805)1.97894392
70Cerebral edema (HP:0002181)1.97170643
71Abnormality of the phalanges of the 5th finger (HP:0004213)1.97152584
72Recurrent abscess formation (HP:0002722)1.95052516
73Lymphoma (HP:0002665)1.94400897
74Meningitis (HP:0001287)1.94334092
75Orchitis (HP:0100796)1.93164270
76Lymphopenia (HP:0001888)1.92715227
77Abnormality of renal resorption (HP:0011038)1.92627803
78Increased intramyocellular lipid droplets (HP:0012240)1.92380574
79Increased serum lactate (HP:0002151)1.90669871
80Premature ovarian failure (HP:0008209)1.89904297
81Vacuolated lymphocytes (HP:0001922)1.89726263
82Obstructive lung disease (HP:0006536)1.89176427
83Chronic obstructive pulmonary disease (HP:0006510)1.89176427
84Abnormality of glycosphingolipid metabolism (HP:0004343)1.88595391
85Abnormality of glycolipid metabolism (HP:0010969)1.88595391
86Abnormality of liposaccharide metabolism (HP:0010968)1.88595391
87Palpebral edema (HP:0100540)1.87441225
88Recurrent viral infections (HP:0004429)1.86854389
89Agammaglobulinemia (HP:0004432)1.86732805
90Hypoplasia of the uterus (HP:0000013)1.86517078
91Abnormal pupillary function (HP:0007686)1.86206297
92Nasolacrimal duct obstruction (HP:0000579)1.85234301
93Recurrent skin infections (HP:0001581)1.84375691
94Abnormality of the costochondral junction (HP:0000919)1.84250243
95Renal cortical cysts (HP:0000803)1.82298060
96Recurrent bacterial skin infections (HP:0005406)1.82115575
97Abnormality of dental color (HP:0011073)1.81683057
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81561793
99Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81561793
100Albinism (HP:0001022)1.80158449

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.16134184
2KDR5.01799733
3TLK13.64992575
4BCKDK3.56707826
5TESK13.19242119
6TXK3.10441017
7VRK22.80170624
8VRK12.75588746
9FES2.40296388
10ZAK2.40188729
11RIPK42.20659604
12SCYL22.18475986
13MAP4K12.15282824
14LIMK12.04795718
15MYLK1.84470034
16ITK1.70452328
17BMPR21.61718736
18CDK81.60314116
19MAP3K121.57781409
20ADRBK21.54820994
21STK101.52403605
22MST41.51487079
23PRKCQ1.50421080
24TEC1.43378491
25SIK31.42363410
26ILK1.40685836
27PDK21.24414038
28TRPM71.21345217
29MAP4K21.20988358
30MAPKAPK31.16063740
31TNK21.14790706
32IKBKB1.11687398
33PIK3CG1.09585325
34PIK3CA1.06716354
35CSK1.04963581
36SIK21.02343923
37SYK0.99676845
38LCK0.98040159
39BTK0.97619757
40INSRR0.96106803
41BUB10.90642824
42MAP3K50.88601580
43IKBKE0.86615829
44ROCK10.85102209
45DAPK10.84870346
46GRK10.84513862
47GRK60.82299870
48JAK30.80953163
49RPS6KA40.77213380
50TSSK60.72523106
51LYN0.71092572
52STK160.69831286
53TAOK30.69285507
54NUAK10.67296166
55TBK10.66211024
56MAP2K70.64452217
57PIM20.62190768
58PTK2B0.59644413
59GRK50.59505048
60SRPK10.59342755
61CAMKK20.59148032
62PAK40.58541187
63ADRBK10.57845013
64PAK10.54576049
65DAPK30.54147774
66ALK0.52936510
67LMTK20.52425682
68PRKCE0.51939832
69ABL20.51081218
70PHKG10.50060271
71PHKG20.50060271
72CDK40.48459167
73HCK0.47534852
74MARK30.45905587
75MAPK110.45626195
76TAOK20.45605228
77RPS6KA50.45124675
78GRK70.42987117
79PLK20.42749501
80PLK30.42318079
81IGF1R0.42262637
82ABL10.41965395
83ERN10.41806516
84PRKCA0.41065677
85PIM10.40194236
86JAK10.39144300
87LRRK20.38795275
88AURKA0.34362406
89EIF2AK10.33902330
90FYN0.33223379
91CDK190.31030429
92NEK10.30456508
93CAMK2A0.29156560
94FRK0.28775444
95MAP3K80.28303999
96TIE10.27554671
97ZAP700.27211273
98AURKB0.26634077
99PRKCB0.26449669
100NME10.25298017

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.02001838
2Proteasome_Homo sapiens_hsa030504.65061592
3Graft-versus-host disease_Homo sapiens_hsa053323.25180377
4Allograft rejection_Homo sapiens_hsa053303.08917031
5Antigen processing and presentation_Homo sapiens_hsa046123.08862110
6Autoimmune thyroid disease_Homo sapiens_hsa053202.98607058
7Hematopoietic cell lineage_Homo sapiens_hsa046402.55896502
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41443517
9Oxidative phosphorylation_Homo sapiens_hsa001902.39416145
10Type I diabetes mellitus_Homo sapiens_hsa049402.23853108
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.18225062
12T cell receptor signaling pathway_Homo sapiens_hsa046602.17832285
13Rheumatoid arthritis_Homo sapiens_hsa053232.08535063
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.05475947
15Parkinsons disease_Homo sapiens_hsa050121.99767403
16Asthma_Homo sapiens_hsa053101.72465936
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71375042
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66765445
19Shigellosis_Homo sapiens_hsa051311.61964356
20Viral myocarditis_Homo sapiens_hsa054161.58692494
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52089685
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52008098
23Measles_Homo sapiens_hsa051621.51862268
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.48994899
25Alzheimers disease_Homo sapiens_hsa050101.35479401
26Homologous recombination_Homo sapiens_hsa034401.35427388
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32435789
28One carbon pool by folate_Homo sapiens_hsa006701.27071099
29Protein export_Homo sapiens_hsa030601.26547450
30Salmonella infection_Homo sapiens_hsa051321.24344956
31Sulfur metabolism_Homo sapiens_hsa009201.19800926
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17393315
33Malaria_Homo sapiens_hsa051441.17305954
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13800766
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10910193
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03497837
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01563368
38Sulfur relay system_Homo sapiens_hsa041221.00220417
39Huntingtons disease_Homo sapiens_hsa050160.99309727
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93179507
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91802780
42N-Glycan biosynthesis_Homo sapiens_hsa005100.91740509
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89475369
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84757974
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83504270
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80050438
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.77859752
48Apoptosis_Homo sapiens_hsa042100.76961357
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76912956
50Selenocompound metabolism_Homo sapiens_hsa004500.73424989
51RNA polymerase_Homo sapiens_hsa030200.72154811
52Collecting duct acid secretion_Homo sapiens_hsa049660.71789964
53Legionellosis_Homo sapiens_hsa051340.68113583
54Galactose metabolism_Homo sapiens_hsa000520.60601593
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.60597451
56Chemokine signaling pathway_Homo sapiens_hsa040620.59796305
57Peroxisome_Homo sapiens_hsa041460.57923313
58Leishmaniasis_Homo sapiens_hsa051400.57439131
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57102905
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56859162
61Nitrogen metabolism_Homo sapiens_hsa009100.53889303
62TNF signaling pathway_Homo sapiens_hsa046680.53408314
63Cardiac muscle contraction_Homo sapiens_hsa042600.52443132
64Olfactory transduction_Homo sapiens_hsa047400.52190560
65Herpes simplex infection_Homo sapiens_hsa051680.47988153
66Ribosome_Homo sapiens_hsa030100.47181607
67Glutathione metabolism_Homo sapiens_hsa004800.45321215
68Lysosome_Homo sapiens_hsa041420.45058269
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45049201
70Epstein-Barr virus infection_Homo sapiens_hsa051690.44973415
71Phototransduction_Homo sapiens_hsa047440.43677564
72Systemic lupus erythematosus_Homo sapiens_hsa053220.42455522
73African trypanosomiasis_Homo sapiens_hsa051430.42199805
74HTLV-I infection_Homo sapiens_hsa051660.40742938
75Pertussis_Homo sapiens_hsa051330.39269317
76Nucleotide excision repair_Homo sapiens_hsa034200.37459539
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37195785
78Phagosome_Homo sapiens_hsa041450.37140175
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37104898
80Caffeine metabolism_Homo sapiens_hsa002320.33613566
81Platelet activation_Homo sapiens_hsa046110.31607296
82Spliceosome_Homo sapiens_hsa030400.30562087
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28782542
84RNA degradation_Homo sapiens_hsa030180.28435561
85Basal transcription factors_Homo sapiens_hsa030220.28209705
86Tuberculosis_Homo sapiens_hsa051520.27866566
87Staphylococcus aureus infection_Homo sapiens_hsa051500.27013770
88Purine metabolism_Homo sapiens_hsa002300.25783528
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25600386
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.23882013
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23040658
92Pyrimidine metabolism_Homo sapiens_hsa002400.22469917
93Endocytosis_Homo sapiens_hsa041440.21564573
94Influenza A_Homo sapiens_hsa051640.21288554
95Salivary secretion_Homo sapiens_hsa049700.20158299
96Chemical carcinogenesis_Homo sapiens_hsa052040.19658648
97p53 signaling pathway_Homo sapiens_hsa041150.19535456
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19100061
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18830649
100Toxoplasmosis_Homo sapiens_hsa051450.17494621

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