MSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact7.62510717
2modulation by symbiont of host immune response (GO:0052553)7.62510717
3positive regulation by symbiont of host defense response (GO:0052509)7.62510717
4modulation by symbiont of host defense response (GO:0052031)7.62510717
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.62510717
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.62510717
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.25593067
8oligosaccharide catabolic process (GO:0009313)5.89616013
9glycosphingolipid catabolic process (GO:0046479)5.67993649
10response to peptidoglycan (GO:0032494)5.59798240
11regulation of interferon-beta biosynthetic process (GO:0045357)5.46541074
12cellular response to thyroid hormone stimulus (GO:0097067)5.45871692
13neutrophil activation involved in immune response (GO:0002283)5.43556129
14macrophage activation involved in immune response (GO:0002281)5.41290195
15positive regulation of interferon-alpha production (GO:0032727)5.12038028
16glycolipid catabolic process (GO:0019377)5.10581473
17response to host immune response (GO:0052572)5.09486981
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.09486981
19amino sugar catabolic process (GO:0046348)5.09337925
20positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.89691351
21regulation of interferon-alpha production (GO:0032647)4.86911848
22ceramide catabolic process (GO:0046514)4.72653433
23microglial cell activation (GO:0001774)4.66418657
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.55511959
25response to host (GO:0075136)4.55511959
26response to host defenses (GO:0052200)4.55511959
27respiratory burst (GO:0045730)4.52074548
28immunoglobulin mediated immune response (GO:0016064)4.51261473
29hydrogen peroxide biosynthetic process (GO:0050665)4.23044210
30regulation of macrophage chemotaxis (GO:0010758)4.16368026
31response to thyroid hormone (GO:0097066)4.04755134
32regulation of mononuclear cell migration (GO:0071675)3.98872141
33macrophage activation (GO:0042116)3.94547602
34detection of molecule of bacterial origin (GO:0032490)3.91708839
35myeloid cell activation involved in immune response (GO:0002275)3.91605862
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.91012698
37positive regulation of cellular amide metabolic process (GO:0034250)3.84171011
38T-helper 1 type immune response (GO:0042088)3.80481024
39positive regulation of chemokine biosynthetic process (GO:0045080)3.80432106
40production of molecular mediator involved in inflammatory response (GO:0002532)3.72917637
41positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.70814596
42positive regulation of interferon-beta production (GO:0032728)3.70738869
43reactive oxygen species biosynthetic process (GO:1903409)3.70447728
44superoxide anion generation (GO:0042554)3.67506749
45granulocyte activation (GO:0036230)3.66445578
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.63817262
47I-kappaB phosphorylation (GO:0007252)3.59878617
48* regulation of cholesterol storage (GO:0010885)3.59696868
49N-acetylneuraminate metabolic process (GO:0006054)3.57382461
50membrane lipid catabolic process (GO:0046466)3.53907770
51response to muramyl dipeptide (GO:0032495)3.53518883
52natural killer cell mediated cytotoxicity (GO:0042267)3.52556634
53natural killer cell mediated immunity (GO:0002228)3.52556634
54neutrophil activation (GO:0042119)3.48495789
55negative regulation of nitric oxide biosynthetic process (GO:0045019)3.47648055
56positive regulation of antigen processing and presentation (GO:0002579)3.47325867
57sphingolipid catabolic process (GO:0030149)3.46377515
58eosinophil migration (GO:0072677)3.45937394
59lymphocyte chemotaxis (GO:0048247)3.42416990
60regulation of interleukin-8 biosynthetic process (GO:0045414)3.39552304
61regulation of B cell receptor signaling pathway (GO:0050855)3.37345041
62cellular extravasation (GO:0045123)3.33803780
63positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.32520666
64negative regulation of interleukin-17 production (GO:0032700)3.32236942
65type I interferon signaling pathway (GO:0060337)3.31606469
66cellular response to type I interferon (GO:0071357)3.31606469
67positive regulation of mast cell activation (GO:0033005)3.31543145
68response to type I interferon (GO:0034340)3.29448039
69response to interferon-alpha (GO:0035455)3.27222753
70B cell mediated immunity (GO:0019724)3.26822625
71regulation of hypersensitivity (GO:0002883)3.25197535
72negative regulation of interleukin-12 production (GO:0032695)3.25191399
73keratan sulfate catabolic process (GO:0042340)3.24923724
74positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.24557100
75regulation of mast cell degranulation (GO:0043304)3.24466196
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.23649570
77positive regulation of mast cell degranulation (GO:0043306)3.23649570
78positive regulation of heat generation (GO:0031652)3.22103832
79fat-soluble vitamin biosynthetic process (GO:0042362)3.18543071
80neutrophil mediated immunity (GO:0002446)3.17194175
81positive regulation of cholesterol efflux (GO:0010875)3.14649154
82positive regulation of toll-like receptor signaling pathway (GO:0034123)3.13713753
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.13239996
84ganglioside metabolic process (GO:0001573)3.10421845
85myeloid dendritic cell differentiation (GO:0043011)3.10024024
86regulation of monocyte chemotaxis (GO:0090025)3.09927784
87positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.09836758
88regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08318344
89regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.07476932
90regulation of mast cell activation involved in immune response (GO:0033006)3.06637963
91regulation of mast cell activation (GO:0033003)3.05970572
92response to xenobiotic stimulus (GO:0009410)3.04890617
93interferon-gamma-mediated signaling pathway (GO:0060333)3.03954281
94leukocyte mediated cytotoxicity (GO:0001909)3.02813226
95regulation of chemokine biosynthetic process (GO:0045073)3.01447206
96negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.01123803
97vitamin D metabolic process (GO:0042359)3.00888425
98positive regulation of monocyte chemotaxis (GO:0090026)3.00255979
99intracellular pH reduction (GO:0051452)3.00079324
100positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.99961049
101positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98810890
102phagosome maturation (GO:0090382)2.97923081
103positive regulation of gamma-delta T cell activation (GO:0046645)2.97697037
104low-density lipoprotein particle clearance (GO:0034383)2.97561781
105positive regulation of macrophage cytokine production (GO:0060907)2.97407501
106positive regulation of lymphocyte migration (GO:2000403)2.97153404
107positive regulation of chemokine production (GO:0032722)2.97030531
108regulation of antigen processing and presentation (GO:0002577)2.96512838
109monocyte chemotaxis (GO:0002548)2.95438163
110apoptotic cell clearance (GO:0043277)2.94842119
111glucosamine-containing compound catabolic process (GO:1901072)2.92431129
112positive regulation of type 2 immune response (GO:0002830)2.91766325
113regulation of fever generation (GO:0031620)2.91243742
114cytokine secretion (GO:0050663)2.90708216
115low-density lipoprotein particle remodeling (GO:0034374)2.90354812
116negative regulation of lipid storage (GO:0010888)2.89535865
117pinocytosis (GO:0006907)2.89353845
118cellular response to interferon-alpha (GO:0035457)2.89154407
119neutrophil chemotaxis (GO:0030593)2.88652965
120positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88110047
121detection of external biotic stimulus (GO:0098581)2.87435553
122negative regulation of mast cell activation (GO:0033004)2.87330071
123germinal center formation (GO:0002467)2.87037196
124eosinophil chemotaxis (GO:0048245)2.86589002
125positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.86427828
126detection of other organism (GO:0098543)2.86397738
127cell adhesion mediated by integrin (GO:0033627)2.85265599
128regulation of integrin activation (GO:0033623)2.84140169
129positive regulation of leukocyte degranulation (GO:0043302)2.82983734
130myeloid leukocyte activation (GO:0002274)2.82435780
131myeloid dendritic cell activation (GO:0001773)2.82347879
132positive regulation of sterol transport (GO:0032373)2.82073168
133positive regulation of cholesterol transport (GO:0032376)2.82073168
134neutrophil migration (GO:1990266)2.80279061
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79985128
136negative regulation of interleukin-1 beta production (GO:0032691)2.78779377
137negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78691430
138negative regulation of cell killing (GO:0031342)2.78691430
139cellular response to ethanol (GO:0071361)2.77900653
140pH reduction (GO:0045851)2.73519363
141positive regulation of bone resorption (GO:0045780)2.71030606
142positive regulation of bone remodeling (GO:0046852)2.71030606
143regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70659257
144regulation of vitamin D biosynthetic process (GO:0060556)2.70658252
145lysosome organization (GO:0007040)2.69284422
146lytic vacuole organization (GO:0080171)2.69284422
147osteoclast differentiation (GO:0030316)2.69111831
148cellular response to interferon-gamma (GO:0071346)2.67851914
149peptide catabolic process (GO:0043171)2.67360908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.43883410
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.07525510
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.67492192
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.90742421
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.55268722
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.31673212
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.00538014
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.83084236
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.56988570
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16556819
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.05105915
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89554967
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.81827854
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59397816
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.44641361
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43037510
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41137057
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38094798
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23448882
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20575174
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.18644951
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14546945
23SPI1_23547873_ChIP-Seq_NB4_Human2.03624633
24PU_27001747_Chip-Seq_BMDM_Mouse1.90289522
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.87068750
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85716134
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83832665
28VDR_24787735_ChIP-Seq_THP-1_Human1.83541064
29CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.80134011
30SPI1_23127762_ChIP-Seq_K562_Human1.77597852
31CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67680412
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59604716
33VDR_24763502_ChIP-Seq_THP-1_Human1.59421479
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.55142208
35SCL_19346495_ChIP-Seq_HPC-7_Human1.51855309
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47281507
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46672779
38CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46215026
39CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44710856
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34959371
41MYB_26560356_Chip-Seq_TH2_Human1.34441714
42RUNX_20019798_ChIP-Seq_JUKART_Human1.33578756
43GATA1_22025678_ChIP-Seq_K562_Human1.32699467
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.31783895
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30412812
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27858257
47PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27518870
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25690015
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24871270
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23496386
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21960389
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20092472
53STAT1_20625510_ChIP-Seq_HELA_Human1.19055823
54MAF_26560356_Chip-Seq_TH1_Human1.19016034
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16619787
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16487450
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.15460346
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.11937127
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.11106623
60MYB_26560356_Chip-Seq_TH1_Human1.10695141
61GATA3_26560356_Chip-Seq_TH2_Human1.07045835
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05985316
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04634963
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03897345
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03323619
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01795907
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01345838
68VDR_21846776_ChIP-Seq_THP-1_Human0.98350301
69NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97984229
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97984229
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97612054
72PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97367426
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96730673
74CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96138076
75SMRT_27268052_Chip-Seq_Bcells_Human0.95695561
76GATA1_19941826_ChIP-Seq_K562_Human0.94337387
77SMAD_19615063_ChIP-ChIP_OVARY_Human0.93969506
78EGR1_19032775_ChIP-ChIP_M12_Human0.92640068
79GATA3_27048872_Chip-Seq_THYMUS_Human0.92562567
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91001605
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89420543
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87605061
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85945079
84ESR1_21235772_ChIP-Seq_MCF-7_Human0.85799162
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85746004
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84551695
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83568737
88SOX2_20726797_ChIP-Seq_SW620_Human0.82683231
89TFEB_21752829_ChIP-Seq_HELA_Human0.81898419
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81372354
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80309884
92UTX_26944678_Chip-Seq_JUKART_Human0.76980660
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76179487
94SPI1_20517297_ChIP-Seq_HL60_Human0.75448864
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.74419420
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73834214
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73693743
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73133314
99* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73033696
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72436181
101* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72403345
102GATA2_19941826_ChIP-Seq_K562_Human0.71984766
103CJUN_26792858_Chip-Seq_BT549_Human0.71012554
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70746861
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.70289322
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69851886
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.69720336
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.69720336
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.68478820
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68333597
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67641926
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66239519
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64679395
114CRX_20693478_ChIP-Seq_RETINA_Mouse0.64250588
115TCF7_22412390_ChIP-Seq_EML_Mouse0.63550488
116PU1_27457419_Chip-Seq_LIVER_Mouse0.63439421
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.63341507
118GATA1_19941827_ChIP-Seq_MEL86_Mouse0.63025871
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62981093
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.61786486
121PRDM14_20953172_ChIP-Seq_ESCs_Human0.59923344
122* TP63_23658742_ChIP-Seq_EP156T_Human0.59806491
123KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.59653510
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.59276046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19429003
2MP0003436_decreased_susceptibility_to4.17772635
3MP0005058_abnormal_lysosome_morphology3.87642566
4MP0003303_peritoneal_inflammation3.74644317
5MP0009785_altered_susceptibility_to3.39175358
6* MP0002419_abnormal_innate_immunity3.28315097
7MP0002148_abnormal_hypersensitivity_rea3.22854191
8MP0006082_CNS_inflammation3.21091396
9MP0005000_abnormal_immune_tolerance3.07451377
10MP0002139_abnormal_hepatobiliary_system2.94466038
11MP0003724_increased_susceptibility_to2.84577802
12* MP0005025_abnormal_response_to2.82173828
13MP0003172_abnormal_lysosome_physiology2.69669606
14MP0001790_abnormal_immune_system2.60610159
15MP0005387_immune_system_phenotype2.60610159
16MP0000569_abnormal_digit_pigmentation2.52234778
17* MP0002452_abnormal_antigen_presenting2.46386903
18MP0001533_abnormal_skeleton_physiology2.33305875
19MP0001800_abnormal_humoral_immune2.30516399
20* MP0002723_abnormal_immune_serum2.27122681
21MP0005464_abnormal_platelet_physiology2.20077223
22MP0000685_abnormal_immune_system2.19637656
23MP0004510_myositis2.13269315
24MP0009840_abnormal_foam_cell2.08874401
25MP0003075_altered_response_to1.98358578
26MP0004947_skin_inflammation1.97306902
27* MP0001819_abnormal_immune_cell1.96478568
28* MP0002420_abnormal_adaptive_immunity1.93775447
29MP0009278_abnormal_bone_marrow1.91530125
30MP0003191_abnormal_cellular_cholesterol1.91384009
31MP0000343_altered_response_to1.91281349
32MP0005671_abnormal_response_to1.90513823
33MP0009764_decreased_sensitivity_to1.89849082
34MP0003448_altered_tumor_morphology1.85663915
35MP0001845_abnormal_inflammatory_respons1.83349590
36MP0008469_abnormal_protein_level1.75928215
37MP0002405_respiratory_system_inflammati1.70890127
38MP0003690_abnormal_glial_cell1.67452007
39MP0003195_calcinosis1.63992096
40MP0003300_gastrointestinal_ulcer1.62947127
41MP0005365_abnormal_bile_salt1.57695021
42MP0005166_decreased_susceptibility_to1.51189152
43MP0003329_amyloid_beta_deposits1.50927576
44MP0002998_abnormal_bone_remodeling1.47948865
45MP0001853_heart_inflammation1.42841413
46MP0010155_abnormal_intestine_physiology1.41788910
47MP0003183_abnormal_peptide_metabolism1.39081161
48* MP0000604_amyloidosis1.38789632
49MP0002006_tumorigenesis1.34071857
50MP0000716_abnormal_immune_system1.33964942
51MP0001545_abnormal_hematopoietic_system1.30914528
52MP0005397_hematopoietic_system_phenotyp1.30914528
53MP0000858_altered_metastatic_potential1.28505366
54MP0005167_abnormal_blood-brain_barrier1.28404686
55MP0005310_abnormal_salivary_gland1.26198736
56MP0010307_abnormal_tumor_latency1.25087960
57MP0009333_abnormal_splenocyte_physiolog1.23112067
58MP0010386_abnormal_urinary_bladder1.22108956
59MP0003806_abnormal_nucleotide_metabolis1.18837508
60MP0005164_abnormal_response_to1.18802175
61MP0009763_increased_sensitivity_to1.18598056
62MP0005083_abnormal_biliary_tract1.17896317
63MP0002398_abnormal_bone_marrow1.14210186
64MP0008004_abnormal_stomach_pH1.12911339
65MP0000689_abnormal_spleen_morphology1.12466632
66MP0003566_abnormal_cell_adhesion1.12159692
67MP0005390_skeleton_phenotype1.07417627
68MP0005174_abnormal_tail_pigmentation1.06138558
69MP0002429_abnormal_blood_cell1.05402893
70MP0003828_pulmonary_edema1.04745073
71MP0004019_abnormal_vitamin_homeostasis1.04209282
72MP0002166_altered_tumor_susceptibility1.04131256
73MP0002277_abnormal_respiratory_mucosa1.03493315
74MP0005076_abnormal_cell_differentiation1.02962311
75MP0001851_eye_inflammation1.02782949
76MP0003656_abnormal_erythrocyte_physiolo1.02709911
77MP0004782_abnormal_surfactant_physiolog1.01584770
78MP0002837_dystrophic_cardiac_calcinosis1.01245398
79MP0005647_abnormal_sex_gland0.97993604
80MP0002254_reproductive_system_inflammat0.97619125
81MP0006054_spinal_hemorrhage0.96986990
82MP0005451_abnormal_body_composition0.96866693
83MP0008875_abnormal_xenobiotic_pharmacok0.96824532
84MP0003186_abnormal_redox_activity0.96737901
85MP0001542_abnormal_bone_strength0.96512619
86MP0005257_abnormal_intraocular_pressure0.94320069
87MP0008438_abnormal_cutaneous_collagen0.92456762
88MP0002722_abnormal_immune_system0.92215928
89MP0003879_abnormal_hair_cell0.91138780
90MP0002877_abnormal_melanocyte_morpholog0.90846040
91MP0008260_abnormal_autophagy0.90673976
92MP0002933_joint_inflammation0.90548946
93MP0000249_abnormal_blood_vessel0.87445590
94MP0003633_abnormal_nervous_system0.85073825
95MP0000371_diluted_coat_color0.80832513
96MP0002138_abnormal_hepatobiliary_system0.79953163
97MP0003646_muscle_fatigue0.78201886
98MP0003091_abnormal_cell_migration0.77534057
99MP0003705_abnormal_hypodermis_morpholog0.77231721
100MP0000015_abnormal_ear_pigmentation0.76037296
101MP0005595_abnormal_vascular_smooth0.75423853
102MP0005646_abnormal_pituitary_gland0.71862507
103MP0005023_abnormal_wound_healing0.70526493
104MP0005165_increased_susceptibility_to0.70035336
105MP0003453_abnormal_keratinocyte_physiol0.69020235
106MP0002332_abnormal_exercise_endurance0.68867669
107MP0000465_gastrointestinal_hemorrhage0.68804737
108MP0002136_abnormal_kidney_physiology0.68355678
109MP0000609_abnormal_liver_physiology0.67935014
110* MP0003632_abnormal_nervous_system0.67854691
111MP0003795_abnormal_bone_structure0.67718887
112MP0005319_abnormal_enzyme/_coenzyme0.66572150
113MP0004858_abnormal_nervous_system0.66218107
114MP0004883_abnormal_blood_vessel0.65828432
115MP0001756_abnormal_urination0.64960110
116MP0003634_abnormal_glial_cell0.64287886
117MP0001958_emphysema0.64184732
118MP0001663_abnormal_digestive_system0.63381803
119MP0000767_abnormal_smooth_muscle0.62277936
120MP0002118_abnormal_lipid_homeostasis0.61185108
121MP0005197_abnormal_uvea_morphology0.60599660
122MP0002090_abnormal_vision0.59069020
123MP0008873_increased_physiological_sensi0.56763515
124MP0004130_abnormal_muscle_cell0.54669570
125MP0000920_abnormal_myelination0.53670495

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.74408420
2Recurrent bacterial skin infections (HP:0005406)7.06425003
3Eczematoid dermatitis (HP:0000976)6.87302526
4Recurrent gram-negative bacterial infections (HP:0005420)6.72724931
5Systemic lupus erythematosus (HP:0002725)5.87428542
6Vacuolated lymphocytes (HP:0001922)5.36967361
7Abnormality of macrophages (HP:0004311)5.25524659
8Increased cerebral lipofuscin (HP:0011813)4.77476633
9Mediastinal lymphadenopathy (HP:0100721)4.63181313
10Gingivitis (HP:0000230)4.44123821
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.43211666
12Stomatitis (HP:0010280)4.36597040
13Recurrent skin infections (HP:0001581)4.16562125
14Glomerulonephritis (HP:0000099)4.15669989
15Autoimmune thrombocytopenia (HP:0001973)4.09684077
16Dysostosis multiplex (HP:0000943)3.92077683
17Axonal loss (HP:0003447)3.82982547
18Disinhibition (HP:0000734)3.82213536
19Mutism (HP:0002300)3.79868568
20Thick nail (HP:0001805)3.77468916
21Neurofibrillary tangles (HP:0002185)3.70763183
22Obstructive lung disease (HP:0006536)3.66326223
23Chronic obstructive pulmonary disease (HP:0006510)3.66326223
24Elevated erythrocyte sedimentation rate (HP:0003565)3.64286048
25Pustule (HP:0200039)3.47621404
26Orchitis (HP:0100796)3.42135079
27Myositis (HP:0100614)3.38084636
28Periodontitis (HP:0000704)3.36629564
29Abnormality of glycolipid metabolism (HP:0010969)3.32478443
30Abnormality of liposaccharide metabolism (HP:0010968)3.32478443
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.32478443
32Myocardial infarction (HP:0001658)3.31113345
33Recurrent fungal infections (HP:0002841)3.29139959
34Urinary glycosaminoglycan excretion (HP:0003541)3.24145233
35Mucopolysacchariduria (HP:0008155)3.24145233
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.22913951
37Retrobulbar optic neuritis (HP:0100654)3.17098121
38Optic neuritis (HP:0100653)3.17098121
39Abnormality of polysaccharide metabolism (HP:0011012)3.09226028
40Abnormality of glycosaminoglycan metabolism (HP:0004371)3.09226028
41Abnormality of mucopolysaccharide metabolism (HP:0011020)3.09226028
42Abnormality of complement system (HP:0005339)3.00633353
43Urticaria (HP:0001025)2.99891532
44Joint hemorrhage (HP:0005261)2.97181598
45Basal ganglia calcification (HP:0002135)2.89545804
46Complement deficiency (HP:0004431)2.86866969
47Vasculitis (HP:0002633)2.82587288
48Recurrent viral infections (HP:0004429)2.82166900
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70777867
50Cellulitis (HP:0100658)2.70691984
51Nephritis (HP:0000123)2.68601495
52Agnosia (HP:0010524)2.67902685
53Loss of speech (HP:0002371)2.66458564
54Retinal atrophy (HP:0001105)2.63829177
55Purpura (HP:0000979)2.62738557
56Abnormality of the periventricular white matter (HP:0002518)2.59959089
57Hematochezia (HP:0002573)2.59914890
58Metaphyseal irregularity (HP:0003025)2.57200956
59Tetraparesis (HP:0002273)2.56860610
60Interstitial pulmonary disease (HP:0006530)2.53512920
61Osteomyelitis (HP:0002754)2.46571048
62Pathologic fracture (HP:0002756)2.46465276
63Cerebral inclusion bodies (HP:0100314)2.42731660
64Hepatosplenomegaly (HP:0001433)2.42319602
65Upper motor neuron abnormality (HP:0002127)2.42062011
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.41583158
67Osteolytic defects of the hand bones (HP:0009699)2.41583158
68Xanthomatosis (HP:0000991)2.41397058
69Leukocytosis (HP:0001974)2.41149141
70Global brain atrophy (HP:0002283)2.39370312
71Recurrent pneumonia (HP:0006532)2.38214912
72Gingival bleeding (HP:0000225)2.38160656
73Pulmonary infiltrates (HP:0002113)2.34276152
74Premature loss of primary teeth (HP:0006323)2.32164066
75Nuclear cataract (HP:0100018)2.31670487
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31660729
77Recurrent cutaneous fungal infections (HP:0011370)2.29615400
78Chronic mucocutaneous candidiasis (HP:0002728)2.29615400
79Progressive neurologic deterioration (HP:0002344)2.28447634
80Neuronal loss in central nervous system (HP:0002529)2.27040562
81Arterial thrombosis (HP:0004420)2.22849724
82Bone pain (HP:0002653)2.18998798
83Meningitis (HP:0001287)2.15159867
84Amyloidosis (HP:0011034)2.15041455
85Dementia (HP:0000726)2.14896865
86J-shaped sella turcica (HP:0002680)2.14598021
87Abnormality of the lumbar spine (HP:0100712)2.13483543
88Increased CSF protein (HP:0002922)2.13458368
89Increased IgM level (HP:0003496)2.08228227
90T lymphocytopenia (HP:0005403)2.08141282
91Tubulointerstitial fibrosis (HP:0005576)2.03783787
92Increased serum ferritin (HP:0003281)2.02238968
93Recurrent lower respiratory tract infections (HP:0002783)2.01403053
94Polyneuropathy (HP:0001271)2.00616677
95Spontaneous hematomas (HP:0007420)2.00444843
96Esophageal varix (HP:0002040)1.99960149
97Abnormality of T cell number (HP:0011839)1.98891353
98Skin nodule (HP:0200036)1.98515186
99Conjunctival telangiectasia (HP:0000524)1.98387733
100Progressive visual loss (HP:0000529)1.95521023
101Peripheral demyelination (HP:0011096)1.95287615
102Apathy (HP:0000741)1.94947714
103Diminished motivation (HP:0000745)1.93692308
104Nausea (HP:0002018)1.91161757
105Personality changes (HP:0000751)1.89905457
106Vertebral compression fractures (HP:0002953)1.89703315
107Hypercholesterolemia (HP:0003124)1.88964984
108Cardiomegaly (HP:0001640)1.87840980
109Inappropriate behavior (HP:0000719)1.85429906
110Epidermoid cyst (HP:0200040)1.83381350
111Thoracic kyphosis (HP:0002942)1.81473368
112Bone cyst (HP:0012062)1.80342980
113Anorexia (HP:0002039)1.80281086
114Albinism (HP:0001022)1.79762418
115Memory impairment (HP:0002354)1.79733084
116Epistaxis (HP:0000421)1.79048505
117Menorrhagia (HP:0000132)1.78761244
118Peritonitis (HP:0002586)1.78314407
119Keratoconjunctivitis sicca (HP:0001097)1.76405369
120Hemoptysis (HP:0002105)1.76363198
121Poor head control (HP:0002421)1.75610437
122Keratoconjunctivitis (HP:0001096)1.75270875
123Asymmetric septal hypertrophy (HP:0001670)1.74651416
124Hypergammaglobulinemia (HP:0010702)1.74466379
125Multiple enchondromatosis (HP:0005701)1.74419500
126Abnormality of iron homeostasis (HP:0011031)1.74287133
127Protuberant abdomen (HP:0001538)1.73885741
128Eosinophilia (HP:0001880)1.72033313
129Colitis (HP:0002583)1.71301726
130Splenomegaly (HP:0001744)1.70629271
131Paralysis (HP:0003470)1.68629012
132Agitation (HP:0000713)1.68581413
133Pulmonary fibrosis (HP:0002206)1.67332393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.51126615
2MAP3K143.92016069
3BLK3.69020434
4TBK13.43955978
5ACVR1B3.33044674
6TYK23.26036372
7IRAK43.03404959
8PBK3.01566178
9IRAK33.00728323
10KIT2.77468058
11IKBKE2.54085892
12PDK22.40429386
13ERN12.21723536
14MAP4K12.04540964
15JAK12.02696073
16IKBKB2.01388818
17JAK31.97099973
18TAOK31.94019834
19TXK1.88756915
20MAP3K131.82652270
21DDR21.80372530
22CSK1.74361115
23FGR1.68715468
24NME21.63249271
25PIM21.60811367
26MST1R1.60417995
27CSF1R1.59190511
28NEK91.55771945
29HCK1.49913503
30ZAP701.36992398
31SYK1.36322367
32FES1.35396576
33LYN1.33513422
34MATK1.29948171
35BMX1.27850452
36CAMK1D1.26020430
37TGFBR21.24829398
38TTN1.21935202
39JAK21.17291974
40LCK1.14979056
41CHUK1.14626167
42RPS6KA41.13572495
43EPHB11.12986154
44CDC42BPA1.11299687
45RIPK11.04183532
46ABL21.04147707
47MARK30.96606530
48BTK0.95535160
49TAOK20.92618897
50STK100.89431730
51EGFR0.87165282
52PIM10.85751347
53GRK70.85741311
54BMPR20.83931236
55TLK10.82401559
56PRKCD0.82255248
57RPS6KA20.81507122
58MAP3K50.79747493
59TEC0.77894369
60FGFR40.77403869
61STK40.76678090
62FGFR30.76564362
63MST40.76479830
64DAPK20.75803801
65MAP2K30.75749329
66EIF2AK20.75328356
67FRK0.73485034
68MAP2K60.71910720
69CAMK1G0.71217861
70ABL10.71151239
71YES10.67986163
72CAMKK20.67760296
73RPS6KC10.66895566
74RPS6KL10.66895566
75ARAF0.62505105
76SIK20.61825822
77MAPK120.60431474
78STK30.60159099
79TGFBR10.59325855
80MAPK70.58530883
81SGK20.58283758
82TIE10.57011146
83SCYL20.56221852
84MAP3K110.55213047
85TAOK10.55206946
86TRPM70.54954299
87CDK60.53604232
88PTK60.53377164
89MOS0.52623885
90FYN0.51777147
91MAP3K30.50956696
92ITK0.50831389
93PINK10.48571929
94GRK10.47839838
95PLK20.47465733
96TESK20.47134763
97CLK10.46630271
98SGK30.46441856
99MAPK40.45850671
100DAPK30.45542375
101PDPK10.42736529
102INSR0.41009806
103LIMK10.40450567
104EPHA30.39578140
105PIK3CG0.39441636
106IGF1R0.39400244
107ERBB40.39239040
108MAPKAPK30.37762396
109PRKCQ0.37757592
110MAPK150.35357110
111ERBB30.34645789
112PDK10.34493963
113MAP3K10.34326509
114CAMKK10.34180826
115PRKACG0.34169049
116GSK3A0.33524945
117MET0.31940671
118LRRK20.31158734
119RPS6KA60.30258342
120DYRK1B0.29914838
121IRAK20.29519881
122PDGFRB0.28811886
123MAPKAPK20.27732346
124MAP3K100.27461950
125PKN20.26084517
126ADRBK20.24555607
127IRAK10.24453002
128SRC0.23526918

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.59848268
2Leishmaniasis_Homo sapiens_hsa051403.43857831
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.92172371
4Legionellosis_Homo sapiens_hsa051342.71857249
5Pertussis_Homo sapiens_hsa051332.68718965
6Lysosome_Homo sapiens_hsa041422.60558000
7Malaria_Homo sapiens_hsa051442.49237065
8Osteoclast differentiation_Homo sapiens_hsa043802.44687012
9Tuberculosis_Homo sapiens_hsa051522.39163600
10Graft-versus-host disease_Homo sapiens_hsa053322.38134799
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.30867906
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.22917443
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21809872
14Rheumatoid arthritis_Homo sapiens_hsa053232.19406515
15* Phagosome_Homo sapiens_hsa041452.14020978
16Other glycan degradation_Homo sapiens_hsa005112.04669904
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97257352
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86718702
19Complement and coagulation cascades_Homo sapiens_hsa046101.86014201
20Measles_Homo sapiens_hsa051621.85399133
21Salmonella infection_Homo sapiens_hsa051321.77216428
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75924915
23Influenza A_Homo sapiens_hsa051641.75008873
24TNF signaling pathway_Homo sapiens_hsa046681.68493339
25Allograft rejection_Homo sapiens_hsa053301.61251768
26Asthma_Homo sapiens_hsa053101.56690890
27B cell receptor signaling pathway_Homo sapiens_hsa046621.55863673
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54087632
29Toxoplasmosis_Homo sapiens_hsa051451.43708290
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34888671
31Hematopoietic cell lineage_Homo sapiens_hsa046401.33355488
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32743933
33African trypanosomiasis_Homo sapiens_hsa051431.30650527
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.29963119
35Herpes simplex infection_Homo sapiens_hsa051681.27394244
36Apoptosis_Homo sapiens_hsa042101.26253364
37Antigen processing and presentation_Homo sapiens_hsa046121.26167251
38Chemokine signaling pathway_Homo sapiens_hsa040621.25867872
39Shigellosis_Homo sapiens_hsa051311.24428204
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17119183
41Type I diabetes mellitus_Homo sapiens_hsa049401.13751813
42Caffeine metabolism_Homo sapiens_hsa002321.11542126
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11144315
44Amoebiasis_Homo sapiens_hsa051461.05967027
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04347556
46Hepatitis C_Homo sapiens_hsa051601.01842872
47Prion diseases_Homo sapiens_hsa050201.00737300
48Hepatitis B_Homo sapiens_hsa051610.96366727
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95956712
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.94934072
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91870534
52Viral myocarditis_Homo sapiens_hsa054160.86439985
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86308692
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.84724097
55Sulfur metabolism_Homo sapiens_hsa009200.84164286
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83694238
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80333995
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78952220
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75297477
60Collecting duct acid secretion_Homo sapiens_hsa049660.74916515
61Ether lipid metabolism_Homo sapiens_hsa005650.74600203
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69438406
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68733954
64Systemic lupus erythematosus_Homo sapiens_hsa053220.67956080
65Tryptophan metabolism_Homo sapiens_hsa003800.67515090
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67070707
67Mineral absorption_Homo sapiens_hsa049780.58423019
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56942773
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.56158646
70Vibrio cholerae infection_Homo sapiens_hsa051100.54784369
71T cell receptor signaling pathway_Homo sapiens_hsa046600.53812636
72Steroid biosynthesis_Homo sapiens_hsa001000.52352157
73Autoimmune thyroid disease_Homo sapiens_hsa053200.51694430
74Pancreatic cancer_Homo sapiens_hsa052120.50889646
75Platelet activation_Homo sapiens_hsa046110.50477353
76Sphingolipid metabolism_Homo sapiens_hsa006000.49220762
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48749364
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.48725167
79Chronic myeloid leukemia_Homo sapiens_hsa052200.48589774
80Acute myeloid leukemia_Homo sapiens_hsa052210.46903496
81Type II diabetes mellitus_Homo sapiens_hsa049300.45718721
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.45233384
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.44523539
84HIF-1 signaling pathway_Homo sapiens_hsa040660.43764106
85Synaptic vesicle cycle_Homo sapiens_hsa047210.41694553
86Galactose metabolism_Homo sapiens_hsa000520.39683357
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38561605
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37589397
89Prolactin signaling pathway_Homo sapiens_hsa049170.37131653
90Primary immunodeficiency_Homo sapiens_hsa053400.36653149
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34392690
92Endocytosis_Homo sapiens_hsa041440.34364867
93Proteoglycans in cancer_Homo sapiens_hsa052050.34213992
94Renin-angiotensin system_Homo sapiens_hsa046140.33196606
95Epstein-Barr virus infection_Homo sapiens_hsa051690.32699678
96Arachidonic acid metabolism_Homo sapiens_hsa005900.32214672
97Small cell lung cancer_Homo sapiens_hsa052220.30671894
98Arginine biosynthesis_Homo sapiens_hsa002200.30293147
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29333553
100Insulin resistance_Homo sapiens_hsa049310.26664867
101ABC transporters_Homo sapiens_hsa020100.24088065
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22781944
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22027863
104Viral carcinogenesis_Homo sapiens_hsa052030.21903916
105VEGF signaling pathway_Homo sapiens_hsa043700.21471477
106PPAR signaling pathway_Homo sapiens_hsa033200.20571601
107Histidine metabolism_Homo sapiens_hsa003400.19332421
108Dorso-ventral axis formation_Homo sapiens_hsa043200.19140372
109Glutathione metabolism_Homo sapiens_hsa004800.18144444
110Ovarian steroidogenesis_Homo sapiens_hsa049130.17779409
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15189131
112Renin secretion_Homo sapiens_hsa049240.14822783
113Starch and sucrose metabolism_Homo sapiens_hsa005000.14541748
114Notch signaling pathway_Homo sapiens_hsa043300.14522826
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14218570
116Oxidative phosphorylation_Homo sapiens_hsa001900.13417302
117Linoleic acid metabolism_Homo sapiens_hsa005910.11188276
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09703237
119Glycerolipid metabolism_Homo sapiens_hsa005610.08354946
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05993565
121Bladder cancer_Homo sapiens_hsa052190.05870023

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