MSRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.35936044
2regulation of DNA methylation (GO:0044030)7.06341826
3L-phenylalanine catabolic process (GO:0006559)7.00714213
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.00714213
5L-phenylalanine metabolic process (GO:0006558)6.82060389
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.82060389
7negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.74534737
8aromatic amino acid family catabolic process (GO:0009074)6.56115654
9piRNA metabolic process (GO:0034587)6.22962850
10indole-containing compound catabolic process (GO:0042436)6.13686121
11indolalkylamine catabolic process (GO:0046218)6.13686121
12tryptophan catabolic process (GO:0006569)6.13686121
13glyoxylate metabolic process (GO:0046487)6.06460709
14regulation of retinoic acid receptor signaling pathway (GO:0048385)5.83392498
15retinal cone cell development (GO:0046549)5.79478160
16kynurenine metabolic process (GO:0070189)5.78797257
17tryptophan metabolic process (GO:0006568)5.71806494
18lysine metabolic process (GO:0006553)5.53893947
19lysine catabolic process (GO:0006554)5.53893947
20cysteine metabolic process (GO:0006534)5.50372581
21bile acid biosynthetic process (GO:0006699)5.43378935
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.27700973
23glycine transport (GO:0015816)5.23884344
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.16126699
25sulfur amino acid catabolic process (GO:0000098)5.13299354
26urea cycle (GO:0000050)4.97873916
27urea metabolic process (GO:0019627)4.97873916
28serine family amino acid catabolic process (GO:0009071)4.96166134
29alpha-linolenic acid metabolic process (GO:0036109)4.92639421
30cellular ketone body metabolic process (GO:0046950)4.90540468
31homocysteine metabolic process (GO:0050667)4.77052191
32drug transmembrane transport (GO:0006855)4.76021251
33meiotic cell cycle (GO:0051321)4.75493751
34aromatic amino acid family metabolic process (GO:0009072)4.74379195
35multicellular organism reproduction (GO:0032504)4.72830164
36amino-acid betaine metabolic process (GO:0006577)4.72458612
37nitrogen cycle metabolic process (GO:0071941)4.64508428
38urate metabolic process (GO:0046415)4.63376773
39alpha-amino acid catabolic process (GO:1901606)4.58529395
40high-density lipoprotein particle remodeling (GO:0034375)4.57876880
41bile acid metabolic process (GO:0008206)4.52907270
42regulation of acrosome reaction (GO:0060046)4.52393984
43L-amino acid import (GO:0043092)4.51832259
44regulation of meiosis I (GO:0060631)4.41445082
45drug catabolic process (GO:0042737)4.41132301
46negative regulation of fibrinolysis (GO:0051918)4.38491979
47complement activation, alternative pathway (GO:0006957)4.38363143
48short-chain fatty acid metabolic process (GO:0046459)4.35647764
49cellular amino acid catabolic process (GO:0009063)4.31721616
50regulation of triglyceride catabolic process (GO:0010896)4.31611422
51cellular biogenic amine catabolic process (GO:0042402)4.30396730
52amine catabolic process (GO:0009310)4.30396730
53indolalkylamine metabolic process (GO:0006586)4.29275955
54protein carboxylation (GO:0018214)4.26480763
55peptidyl-glutamic acid carboxylation (GO:0017187)4.26480763
56regulation of protein activation cascade (GO:2000257)4.24984253
57regulation of fibrinolysis (GO:0051917)4.24626027
58tyrosine metabolic process (GO:0006570)4.24180323
59DNA methylation involved in gamete generation (GO:0043046)4.23904275
60ketone body metabolic process (GO:1902224)4.22291354
61glutamate metabolic process (GO:0006536)4.21088435
62serine family amino acid metabolic process (GO:0009069)4.21042234
63coenzyme catabolic process (GO:0009109)4.20895636
64cellular modified amino acid catabolic process (GO:0042219)4.18147619
65benzene-containing compound metabolic process (GO:0042537)4.13573843
66aldehyde catabolic process (GO:0046185)4.12686712
67regulation of cholesterol esterification (GO:0010872)4.10072723
682-oxoglutarate metabolic process (GO:0006103)4.08370923
69drug transport (GO:0015893)4.05444115
70exogenous drug catabolic process (GO:0042738)4.03188242
71plasma lipoprotein particle remodeling (GO:0034369)4.02396983
72protein-lipid complex remodeling (GO:0034368)4.02396983
73macromolecular complex remodeling (GO:0034367)4.02396983
74aspartate family amino acid catabolic process (GO:0009068)4.01468967
75regulation of complement activation (GO:0030449)3.97649868
76reverse cholesterol transport (GO:0043691)3.95469162
77serine family amino acid biosynthetic process (GO:0009070)3.93769508
78cellular glucuronidation (GO:0052695)3.93147979
79triglyceride homeostasis (GO:0070328)3.91850205
80acylglycerol homeostasis (GO:0055090)3.91850205
81ethanol oxidation (GO:0006069)3.91297932
82glycine metabolic process (GO:0006544)3.91252710
83organic acid catabolic process (GO:0016054)3.90507765
84carboxylic acid catabolic process (GO:0046395)3.90507765
85negative regulation of cholesterol transport (GO:0032375)3.90470189
86negative regulation of sterol transport (GO:0032372)3.90470189
87fatty acid beta-oxidation (GO:0006635)3.90334783
88acetyl-CoA metabolic process (GO:0006084)3.85774592
89female gamete generation (GO:0007292)3.85048519
90bile acid and bile salt transport (GO:0015721)3.83497122
91flavonoid metabolic process (GO:0009812)3.83455968
92dicarboxylic acid biosynthetic process (GO:0043650)3.82580566
93fatty acid oxidation (GO:0019395)3.82369348
94valine metabolic process (GO:0006573)3.77758954
95lipid oxidation (GO:0034440)3.75413450
96positive regulation of uterine smooth muscle contraction (GO:0070474)3.75003291
97monocarboxylic acid catabolic process (GO:0072329)3.74855438
98phospholipid efflux (GO:0033700)3.71814310
99fatty acid catabolic process (GO:0009062)3.70730799
100imidazole-containing compound metabolic process (GO:0052803)3.69959141
101carnitine metabolic process (GO:0009437)3.67866458
102regulation of female receptivity (GO:0045924)3.64527505
103glucuronate metabolic process (GO:0019585)3.64288939
104uronic acid metabolic process (GO:0006063)3.64288939
105branched-chain amino acid catabolic process (GO:0009083)3.63838621
106arginine metabolic process (GO:0006525)3.63191305
107positive regulation of humoral immune response (GO:0002922)3.61868592
108nicotinamide nucleotide biosynthetic process (GO:0019359)3.59680482
109pyridine nucleotide biosynthetic process (GO:0019363)3.59680482
110aggressive behavior (GO:0002118)3.59467186
111NAD biosynthetic process (GO:0009435)3.58849509
112regulation of cytokine production involved in inflammatory response (GO:1900015)3.58108414
113branched-chain amino acid metabolic process (GO:0009081)3.58089310
114cofactor catabolic process (GO:0051187)3.55931414
115female mating behavior (GO:0060180)3.53702104
116disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.52145261
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.52145261
118protein kinase C signaling (GO:0070528)3.51124498
119plasma lipoprotein particle clearance (GO:0034381)3.50674172
120low-density lipoprotein particle remodeling (GO:0034374)3.48567761
121regulation of steroid hormone secretion (GO:2000831)3.45200172
122drug metabolic process (GO:0017144)3.42393625
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39995980
124sleep (GO:0030431)3.27294615
125neutrophil activation involved in immune response (GO:0002283)3.25644282
126regulation of cell maturation (GO:1903429)3.25433908
127neuron fate determination (GO:0048664)3.21553818
128immunoglobulin mediated immune response (GO:0016064)3.21498009
129phosphorelay signal transduction system (GO:0000160)3.20232758
130positive regulation of histone H3-K4 methylation (GO:0051571)3.19855679
131negative regulation of reproductive process (GO:2000242)3.15757996
132response to acidic pH (GO:0010447)3.15369221
133regulation of penile erection (GO:0060405)3.13517756
134negative regulation of cAMP-mediated signaling (GO:0043951)3.04311777
135regulation of uterine smooth muscle contraction (GO:0070472)2.98803637
136oocyte development (GO:0048599)2.97939011
137amino acid import (GO:0043090)2.96661403
138reproduction (GO:0000003)2.94687200
139relaxation of smooth muscle (GO:0044557)2.86659000
140cellular response to pH (GO:0071467)2.86630609
141positive regulation of prostaglandin secretion (GO:0032308)2.84381533
142male meiosis I (GO:0007141)2.81945418
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80619788
144neurotransmitter-gated ion channel clustering (GO:0072578)2.78848823
145organelle membrane fusion (GO:0090174)2.68100684
146positive regulation of reproductive process (GO:2000243)2.64865948
147positive regulation of mast cell activation involved in immune response (GO:0033008)2.63654280
148positive regulation of mast cell degranulation (GO:0043306)2.63654280
149regulation of hypersensitivity (GO:0002883)2.60593031
150response to peptidoglycan (GO:0032494)2.60357056
151regulation of germinal center formation (GO:0002634)2.55385973
152cAMP catabolic process (GO:0006198)2.54142646
153positive regulation of isotype switching (GO:0045830)2.53992437
154positive regulation of gastrulation (GO:2000543)2.51941939
155positive regulation of DNA recombination (GO:0045911)2.51355936
156drinking behavior (GO:0042756)2.50503001
157lipoxygenase pathway (GO:0019372)2.46874047
158gene silencing by RNA (GO:0031047)2.40874192
159regulation of mast cell degranulation (GO:0043304)2.39771511
160positive regulation of digestive system process (GO:0060456)2.38311119
161positive regulation of mast cell activation (GO:0033005)2.38214573
162regulation of mast cell activation involved in immune response (GO:0033006)2.38210171
163inositol phosphate catabolic process (GO:0071545)2.36829570
164maternal behavior (GO:0042711)2.35574473
165meiosis I (GO:0007127)2.35135790
166regulation of neuron projection regeneration (GO:0070570)2.33749640
167regulation of axon regeneration (GO:0048679)2.33749640
168regulation of histone H3-K9 methylation (GO:0051570)2.30498586
169oxidative demethylation (GO:0070989)2.29736811
170regulation of mast cell activation (GO:0033003)2.29405074
171oogenesis (GO:0048477)2.27938073
172positive regulation of fatty acid transport (GO:2000193)2.25991404
173autophagic vacuole fusion (GO:0000046)2.25048983
174fat-soluble vitamin biosynthetic process (GO:0042362)2.24182355
175positive regulation of icosanoid secretion (GO:0032305)2.23734384
176positive regulation of actin cytoskeleton reorganization (GO:2000251)2.23712891
177positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.23538531
178very long-chain fatty acid metabolic process (GO:0000038)2.23394487
179fertilization (GO:0009566)2.22312774
180macrophage activation involved in immune response (GO:0002281)2.21035866
181positive regulation of cellular amine metabolic process (GO:0033240)2.20493052
182modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.19859114
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.19859114
184modulation by symbiont of host immune response (GO:0052553)2.19859114
185positive regulation by symbiont of host defense response (GO:0052509)2.19859114
186modulation by symbiont of host defense response (GO:0052031)2.19859114
187modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.19859114
188viral protein processing (GO:0019082)2.17812079
189dopamine biosynthetic process (GO:0042416)2.17379877
190cyclic nucleotide catabolic process (GO:0009214)2.17194307
191positive regulation of defense response to virus by host (GO:0002230)2.16935692
192male meiosis (GO:0007140)2.16727417
193positive regulation of antigen processing and presentation (GO:0002579)2.16214574
194pyrimidine-containing compound transmembrane transport (GO:0072531)2.15857021
195regulation of calcium ion-dependent exocytosis (GO:0017158)2.15826290
196single fertilization (GO:0007338)2.12562360
197phosphatidylinositol dephosphorylation (GO:0046856)2.12474214
198positive regulation of steroid hormone secretion (GO:2000833)2.12376074
199ionotropic glutamate receptor signaling pathway (GO:0035235)2.07761645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.82838563
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.72327188
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.46280774
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.84081336
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.60557878
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.91734907
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.78512836
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88648828
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.69620184
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44122580
11GBX2_23144817_ChIP-Seq_PC3_Human3.14769606
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73546476
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61244444
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30459920
15* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22679509
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09896698
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2166546
18EZH2_22144423_ChIP-Seq_EOC_Human11.0344478
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91159219
20VDR_24787735_ChIP-Seq_THP-1_Human1.82419897
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.78974411
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73766041
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.68474423
24DROSHA_22980978_ChIP-Seq_HELA_Human1.63196173
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61521683
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60968958
27GATA1_22025678_ChIP-Seq_K562_Human1.58846065
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55709484
29* REST_21632747_ChIP-Seq_MESCs_Mouse1.50523755
30* PRDM14_20953172_ChIP-Seq_ESCs_Human1.48673263
31HTT_18923047_ChIP-ChIP_STHdh_Human1.47697352
32ZNF274_21170338_ChIP-Seq_K562_Hela1.46839465
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45276409
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43135394
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40276180
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39053026
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36305614
38* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36254385
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.34059377
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.30585403
41RUNX_20019798_ChIP-Seq_JUKART_Human1.29444754
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23856421
43NANOG_20526341_ChIP-Seq_ESCs_Human1.23829199
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.22316987
45* TCF4_23295773_ChIP-Seq_U87_Human1.20751785
46* AR_25329375_ChIP-Seq_VCAP_Human1.19962566
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18952920
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.18747338
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18401658
50SMRT_27268052_Chip-Seq_Bcells_Human1.14688654
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13846531
52VDR_24763502_ChIP-Seq_THP-1_Human1.09649215
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09055067
54* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08467501
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08386244
56* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07989375
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07920117
58CLOCK_20551151_ChIP-Seq_293T_Human1.07106817
59* CBP_20019798_ChIP-Seq_JUKART_Human1.06074371
60* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06074371
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05593649
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03674560
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03674560
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03348277
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02052219
66TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99273501
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99259489
68* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99230109
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97468636
70NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97315417
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97077465
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97045709
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97017968
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96124912
75GATA1_26923725_Chip-Seq_HPCs_Mouse0.95515068
76KLF4_19829295_ChIP-Seq_ESCs_Human0.95401869
77* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95376403
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95347145
79TAF15_26573619_Chip-Seq_HEK293_Human0.93439840
80P300_19829295_ChIP-Seq_ESCs_Human0.92162607
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92154980
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91848039
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91734017
84RUNX2_22187159_ChIP-Seq_PCA_Human0.91069352
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.90627779
86* TAL1_26923725_Chip-Seq_HPCs_Mouse0.89981134
87* STAT3_23295773_ChIP-Seq_U87_Human0.89341727
88VDR_22108803_ChIP-Seq_LS180_Human0.87029822
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86397264
90SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85632839
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85342297
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84845012
93STAT1_20625510_ChIP-Seq_HELA_Human0.84664131
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84607420
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84383675
96NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83807664
97GATA3_26560356_Chip-Seq_TH2_Human0.82325393
98SPI1_23127762_ChIP-Seq_K562_Human0.81901792
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.80755102
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80239963
101RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79862044
102EZH2_27304074_Chip-Seq_ESCs_Mouse0.78611449
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78505036
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.78330211
105EZH2_27294783_Chip-Seq_ESCs_Mouse0.78238637
106* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78167617
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.78071223
108AR_20517297_ChIP-Seq_VCAP_Human0.77520052
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77220597
110IRF1_19129219_ChIP-ChIP_H3396_Human0.77193304
111TP53_22573176_ChIP-Seq_HFKS_Human0.76999399
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76328937
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76013707
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75956137
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.74304237
116GATA4_25053715_ChIP-Seq_YYC3_Human0.71963987
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71264370
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.71188672
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.70483502
120EGR1_19032775_ChIP-ChIP_M12_Human0.70421845
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70091437
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69651261
123SCL_19346495_ChIP-Seq_HPC-7_Human0.69494454
124* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66717569
125TAF2_19829295_ChIP-Seq_ESCs_Human0.65615456
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.65207383
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63996950
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63592984
129LXR_22292898_ChIP-Seq_THP-1_Human0.63586410
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62866950
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62302491
132MYC_19915707_ChIP-ChIP_AK7_Human0.61643155
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61589516
134* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.61207644
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60988159
136CEBPB_22108803_ChIP-Seq_LS180_Human0.60961662
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60515463
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.59735718
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.59735718
140STAT1_17558387_ChIP-Seq_HELA_Human0.59104753
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58961842
142ELF1_17652178_ChIP-ChIP_JURKAT_Human0.58507906
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.57823064
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.57142543
145BP1_19119308_ChIP-ChIP_Hs578T_Human0.56968360
146ERG_20517297_ChIP-Seq_VCAP_Human0.56276366
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.55916907
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.54956416
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53779231
150NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.53284909
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52831739
152IRF8_27001747_Chip-Seq_BMDM_Mouse0.52123553
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52068332
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51473369
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.51226307
156FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.51169809
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.48859980
158* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48530855
159SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.48351671
160NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.47943529
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.47676731
162BCL6_27268052_Chip-Seq_Bcells_Human0.47568628
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.47220701
164TET1_21451524_ChIP-Seq_MESCs_Mouse0.46796212
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.46479950
166SOX2_22085726_ChIP-Seq_NPCs_Mouse0.46288148
167GATA2_19941826_ChIP-Seq_K562_Human0.46243106
168CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.46242442
169P53_21459846_ChIP-Seq_SAOS-2_Human0.46172127
170STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.46004104
171BCAT_22108803_ChIP-Seq_LS180_Human0.44457096
172CBP_21632823_ChIP-Seq_H3396_Human0.44205219
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44045009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.71338103
2MP0002139_abnormal_hepatobiliary_system7.65528930
3MP0005085_abnormal_gallbladder_physiolo5.75738686
4MP0005365_abnormal_bile_salt5.60769340
5MP0003718_maternal_effect5.25950625
6MP0008875_abnormal_xenobiotic_pharmacok5.00973004
7MP0003806_abnormal_nucleotide_metabolis3.69249986
8MP0003252_abnormal_bile_duct3.47011392
9MP0005332_abnormal_amino_acid3.30339321
10MP0010329_abnormal_lipoprotein_level3.24157337
11MP0003195_calcinosis3.09815942
12MP0009840_abnormal_foam_cell2.66104386
13MP0004019_abnormal_vitamin_homeostasis2.56812124
14MP0003183_abnormal_peptide_metabolism2.52800391
15MP0005083_abnormal_biliary_tract2.44680997
16MP0001666_abnormal_nutrient_absorption2.42758152
17MP0003191_abnormal_cellular_cholesterol2.37892774
18MP0008789_abnormal_olfactory_epithelium2.24225247
19MP0002138_abnormal_hepatobiliary_system2.19538388
20MP0001986_abnormal_taste_sensitivity2.10260708
21MP0008877_abnormal_DNA_methylation2.07427486
22MP0002735_abnormal_chemical_nociception2.06001056
23MP0001764_abnormal_homeostasis2.01277183
24MP0003303_peritoneal_inflammation1.97376219
25MP0002118_abnormal_lipid_homeostasis1.95664096
26MP0005499_abnormal_olfactory_system1.93283631
27MP0005394_taste/olfaction_phenotype1.93283631
28MP0000609_abnormal_liver_physiology1.91569458
29* MP0005319_abnormal_enzyme/_coenzyme1.89797441
30MP0005584_abnormal_enzyme/coenzyme_acti1.87514566
31MP0000465_gastrointestinal_hemorrhage1.82842886
32MP0009643_abnormal_urine_homeostasis1.82672188
33MP0001968_abnormal_touch/_nociception1.80649433
34MP0002148_abnormal_hypersensitivity_rea1.79124072
35MP0002272_abnormal_nervous_system1.65914059
36MP0001501_abnormal_sleep_pattern1.63664091
37MP0005636_abnormal_mineral_homeostasis1.55865180
38MP0003868_abnormal_feces_composition1.53682862
39* MP0003186_abnormal_redox_activity1.51694124
40MP0002736_abnormal_nociception_after1.50939382
41MP0006292_abnormal_olfactory_placode1.46677248
42MP0006036_abnormal_mitochondrial_physio1.46205276
43MP0005410_abnormal_fertilization1.41872301
44MP0002876_abnormal_thyroid_physiology1.41324180
45MP0002234_abnormal_pharynx_morphology1.34801356
46MP0009697_abnormal_copulation1.33994038
47MP0004270_analgesia1.32898977
48MP0005451_abnormal_body_composition1.31609252
49MP0000015_abnormal_ear_pigmentation1.27943077
50MP0009745_abnormal_behavioral_response1.26231759
51MP0009764_decreased_sensitivity_to1.23093326
52MP0003635_abnormal_synaptic_transmissio1.22913684
53MP0002837_dystrophic_cardiac_calcinosis1.22790222
54MP0003656_abnormal_erythrocyte_physiolo1.20676116
55MP0004142_abnormal_muscle_tone1.19107184
56MP0004043_abnormal_pH_regulation1.17663325
57MP0005084_abnormal_gallbladder_morpholo1.13937253
58MP0005397_hematopoietic_system_phenotyp1.12178988
59MP0001545_abnormal_hematopoietic_system1.12178988
60MP0002064_seizures1.11807049
61MP0005000_abnormal_immune_tolerance1.11632506
62MP0001790_abnormal_immune_system1.11130483
63MP0005387_immune_system_phenotype1.11130483
64MP0008469_abnormal_protein_level1.10468534
65MP0002723_abnormal_immune_serum1.10361699
66MP0003011_delayed_dark_adaptation1.09513755
67MP0003699_abnormal_female_reproductive1.09039838
68MP0005551_abnormal_eye_electrophysiolog1.08462252
69MP0004859_abnormal_synaptic_plasticity1.07753389
70MP0005535_abnormal_body_temperature1.07651423
71MP0005646_abnormal_pituitary_gland1.07643170
72MP0000598_abnormal_liver_morphology1.06246850
73MP0000604_amyloidosis1.05107208
74MP0001486_abnormal_startle_reflex1.04163700
75MP0003724_increased_susceptibility_to1.02467126
76MP0001765_abnormal_ion_homeostasis1.02360649
77MP0002452_abnormal_antigen_presenting1.01120073
78MP0001984_abnormal_olfaction1.00436563
79MP0001800_abnormal_humoral_immune0.99928321
80MP0009642_abnormal_blood_homeostasis0.98136319
81MP0002653_abnormal_ependyma_morphology0.97925935
82MP0009763_increased_sensitivity_to0.97747073
83MP0002420_abnormal_adaptive_immunity0.97458785
84MP0001756_abnormal_urination0.97000497
85MP0005670_abnormal_white_adipose0.96516115
86MP0002734_abnormal_mechanical_nocicepti0.95733737
87MP0006035_abnormal_mitochondrial_morpho0.95489316
88MP0002136_abnormal_kidney_physiology0.93842543
89MP0001819_abnormal_immune_cell0.93352524
90MP0002067_abnormal_sensory_capabilities0.92933261
91MP0003880_abnormal_central_pattern0.92171545
92MP0001929_abnormal_gametogenesis0.91978652
93MP0002063_abnormal_learning/memory/cond0.91522507
94MP0005647_abnormal_sex_gland0.90888677
95MP0002277_abnormal_respiratory_mucosa0.90009735
96MP0003633_abnormal_nervous_system0.89966330
97MP0003172_abnormal_lysosome_physiology0.87928978
98MP0005376_homeostasis/metabolism_phenot0.87283450
99MP0002572_abnormal_emotion/affect_behav0.87223979
100MP0000343_altered_response_to0.83729639
101MP0001664_abnormal_digestion0.82600775
102MP0002078_abnormal_glucose_homeostasis0.79904444
103MP0003436_decreased_susceptibility_to0.79442840
104MP0009765_abnormal_xenobiotic_induced0.79366162
105MP0005174_abnormal_tail_pigmentation0.79154038
106MP0003950_abnormal_plasma_membrane0.78178200
107MP0003329_amyloid_beta_deposits0.77384426
108MP0005075_abnormal_melanosome_morpholog0.76735879
109MP0004742_abnormal_vestibular_system0.76668908
110MP0004130_abnormal_muscle_cell0.76597677
111MP0001533_abnormal_skeleton_physiology0.75717983
112MP0002095_abnormal_skin_pigmentation0.75549438
113MP0003136_yellow_coat_color0.74198567
114MP0001970_abnormal_pain_threshold0.73671763
115MP0004510_myositis0.73546882
116MP0003638_abnormal_response/metabolism_0.73052820
117MP0009785_altered_susceptibility_to0.71444810
118MP0004147_increased_porphyrin_level0.71147499
119MP0002822_catalepsy0.70376551
120MP0002971_abnormal_brown_adipose0.69749424
121MP0005266_abnormal_metabolism0.69688826
122MP0005334_abnormal_fat_pad0.65578729
123MP0003075_altered_response_to0.65318113
124MP0005464_abnormal_platelet_physiology0.65223287
125MP0001853_heart_inflammation0.64714761
126MP0005220_abnormal_exocrine_pancreas0.64131646
127MP0008874_decreased_physiological_sensi0.62272469
128MP0000230_abnormal_systemic_arterial0.61929583
129MP0005058_abnormal_lysosome_morphology0.61912176
130MP0008872_abnormal_physiological_respon0.58837012
131MP0005166_decreased_susceptibility_to0.58570838
132MP0005448_abnormal_energy_balance0.57047930
133MP0003646_muscle_fatigue0.56878894
134MP0001845_abnormal_inflammatory_respons0.54467888
135MP0004782_abnormal_surfactant_physiolog0.53908305
136MP0009379_abnormal_foot_pigmentation0.53532562
137MP0002254_reproductive_system_inflammat0.53266664
138MP0003690_abnormal_glial_cell0.51515042
139MP0010368_abnormal_lymphatic_system0.51096518
140MP0008873_increased_physiological_sensi0.49697227
141MP0003953_abnormal_hormone_level0.49566539
142MP0005025_abnormal_response_to0.48290625
143MP0001661_extended_life_span0.46021347
144MP0005408_hypopigmentation0.45166691
145MP0002928_abnormal_bile_duct0.44979504
146MP0000538_abnormal_urinary_bladder0.44883959
147MP0002419_abnormal_innate_immunity0.44705452
148MP0001835_abnormal_antigen_presentation0.44419430
149MP0001663_abnormal_digestive_system0.42239140
150MP0005165_increased_susceptibility_to0.40999325
151MP0005666_abnormal_adipose_tissue0.40814926
152MP0002135_abnormal_kidney_morphology0.34786792
153MP0003879_abnormal_hair_cell0.32941440
154MP0005595_abnormal_vascular_smooth0.31949595
155MP0006082_CNS_inflammation0.31869040
156MP0009115_abnormal_fat_cell0.30055938
157MP0003959_abnormal_lean_body0.29913931
158MP0000639_abnormal_adrenal_gland0.29731950
159MP0005395_other_phenotype0.29702390
160MP0000249_abnormal_blood_vessel0.28317950
161MP0008961_abnormal_basal_metabolism0.27906472

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43328953
2Intrahepatic cholestasis (HP:0001406)5.68865832
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.37456775
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.35470064
5Deep venous thrombosis (HP:0002625)5.34950438
6Xanthomatosis (HP:0000991)5.07858084
7Prolonged partial thromboplastin time (HP:0003645)5.00141078
8Hypobetalipoproteinemia (HP:0003563)4.96648086
9Hyperammonemia (HP:0001987)4.62679451
10Ketosis (HP:0001946)4.52927918
11Hyperglycinuria (HP:0003108)4.47204413
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.45030261
13Hyperlipoproteinemia (HP:0010980)4.44587207
14Hyperglycinemia (HP:0002154)4.26269946
15Abnormality of serine family amino acid metabolism (HP:0010894)4.23694925
16Abnormality of glycine metabolism (HP:0010895)4.23694925
17Abnormality of fatty-acid metabolism (HP:0004359)4.00604606
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97355763
19Joint hemorrhage (HP:0005261)3.91729105
20Complement deficiency (HP:0004431)3.91727074
21Gout (HP:0001997)3.70722654
22Loss of speech (HP:0002371)3.70568997
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.70203149
24Ketoacidosis (HP:0001993)3.67808199
25Hypolipoproteinemia (HP:0010981)3.54958124
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49814867
27Abnormality of liposaccharide metabolism (HP:0010968)3.46464872
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.46464872
29Abnormality of glycolipid metabolism (HP:0010969)3.46464872
30Hypoglycemic coma (HP:0001325)3.43593272
31Fat malabsorption (HP:0002630)3.42409233
32Abnormality of pyrimidine metabolism (HP:0004353)3.41417165
33Abnormality of methionine metabolism (HP:0010901)3.40091009
34Abnormality of the common coagulation pathway (HP:0010990)3.39350031
35Abnormality of nucleobase metabolism (HP:0010932)3.37786422
36Abnormality of purine metabolism (HP:0004352)3.35971050
37Metabolic acidosis (HP:0001942)3.34900134
38Mutism (HP:0002300)3.34705049
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30777527
40Epidermoid cyst (HP:0200040)3.28945936
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28307402
42Dicarboxylic aciduria (HP:0003215)3.28307402
43Delayed CNS myelination (HP:0002188)3.23921284
44Generalized aminoaciduria (HP:0002909)3.22940815
45Diminished motivation (HP:0000745)3.21125954
46Conjugated hyperbilirubinemia (HP:0002908)3.17835481
47Hypophosphatemic rickets (HP:0004912)3.15791541
48Abnormality of serum amino acid levels (HP:0003112)3.12458062
49Apathy (HP:0000741)3.11858787
50Male infertility (HP:0003251)3.11779017
51Lethargy (HP:0001254)3.10172822
52Hyperbilirubinemia (HP:0002904)3.07836127
53Stomatitis (HP:0010280)3.02974880
54Cerebral edema (HP:0002181)3.00680094
55Congenital sensorineural hearing impairment (HP:0008527)2.96316536
56Hypoalphalipoproteinemia (HP:0003233)2.94756807
57Proximal tubulopathy (HP:0000114)2.93683908
58Abnormality of macrophages (HP:0004311)2.90059144
59Recurrent bacterial skin infections (HP:0005406)2.90013720
60Recurrent abscess formation (HP:0002722)2.82686845
61Hypercholesterolemia (HP:0003124)2.80455602
62Myositis (HP:0100614)2.80209411
63Myokymia (HP:0002411)2.78811164
64Abnormality of complement system (HP:0005339)2.77965805
65Abnormality of the intrinsic pathway (HP:0010989)2.77206579
66Alkalosis (HP:0001948)2.74093432
67Abnormality of urine glucose concentration (HP:0011016)2.72925503
68Glycosuria (HP:0003076)2.72925503
69Vomiting (HP:0002013)2.66751979
70Hyperuricemia (HP:0002149)2.65769691
71Increased purine levels (HP:0004368)2.65769691
72Conjunctival telangiectasia (HP:0000524)2.64018323
73Steatorrhea (HP:0002570)2.62626817
74Supernumerary spleens (HP:0009799)2.61378236
75Septo-optic dysplasia (HP:0100842)2.59573549
76Hypokinesia (HP:0002375)2.59484125
77Prolonged neonatal jaundice (HP:0006579)2.53419570
78Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49866119
79Aplasia/Hypoplasia of the fovea (HP:0008060)2.48967817
80Hypoplasia of the fovea (HP:0007750)2.48967817
81Osteomalacia (HP:0002749)2.45792893
82Anterior segment dysgenesis (HP:0007700)2.44929927
83Hepatic necrosis (HP:0002605)2.42741918
84Hepatocellular carcinoma (HP:0001402)2.39401478
85Vascular calcification (HP:0004934)2.36932493
86Neonatal onset (HP:0003623)2.35717852
87Recurrent gram-negative bacterial infections (HP:0005420)2.35509716
88Spontaneous abortion (HP:0005268)2.33664963
89Systemic lupus erythematosus (HP:0002725)2.33484920
90Late onset (HP:0003584)2.33225651
91Orchitis (HP:0100796)2.32946052
92Irritability (HP:0000737)2.31604503
93Acute encephalopathy (HP:0006846)2.29933243
94Malnutrition (HP:0004395)2.26941968
95Spastic diplegia (HP:0001264)2.25353069
96Dysostosis multiplex (HP:0000943)2.23985283
97Pancreatitis (HP:0001733)2.22714260
98Action tremor (HP:0002345)2.22501698
99Nausea (HP:0002018)2.21675607
100Sensorimotor neuropathy (HP:0007141)2.21592952
101Metaphyseal irregularity (HP:0003025)2.21197408
102Albinism (HP:0001022)2.19553380
103Bundle branch block (HP:0011710)2.18165553
104Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15768364
105Hyperactive renin-angiotensin system (HP:0000841)2.13775022
106Increased muscle lipid content (HP:0009058)2.13569632
107Focal motor seizures (HP:0011153)2.13348348
108Optic neuritis (HP:0100653)2.12176171
109Retrobulbar optic neuritis (HP:0100654)2.12176171
110Hydroxyprolinuria (HP:0003080)2.11762149
111Abnormality of proline metabolism (HP:0010907)2.11762149
112Hyperphosphaturia (HP:0003109)2.11328353
113Infertility (HP:0000789)2.09273526
114Skin nodule (HP:0200036)2.08188681
115Hyperventilation (HP:0002883)2.07174995
116Delusions (HP:0000746)2.05426690
117Abnormal ciliary motility (HP:0012262)2.03710449
118Brushfield spots (HP:0001088)2.03461649
119Azoospermia (HP:0000027)2.03152616
120Anhidrosis (HP:0000970)2.01517610
121Abnormality of the fovea (HP:0000493)2.00839669
122Cardiovascular calcification (HP:0011915)2.00718519
123Aplasia/Hypoplasia of the macula (HP:0008059)2.00088740
124Fair hair (HP:0002286)1.99564520
125Neurofibrillary tangles (HP:0002185)1.99503994
126Cholecystitis (HP:0001082)1.99297394
127Abnormal gallbladder physiology (HP:0012438)1.99297394
128Abnormal biliary tract physiology (HP:0012439)1.98929762
129Bile duct proliferation (HP:0001408)1.98929762
130Increased cerebral lipofuscin (HP:0011813)1.98900249
131Enlarged kidneys (HP:0000105)1.98448382
132Opisthotonus (HP:0002179)1.97888446
133Methylmalonic aciduria (HP:0012120)1.96664530
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.96312448
135Absent/shortened dynein arms (HP:0200106)1.96312448
136Cholelithiasis (HP:0001081)1.95973676
137Lactic acidosis (HP:0003128)1.94237223
138Abnormal gallbladder morphology (HP:0012437)1.93984338
139Vacuolated lymphocytes (HP:0001922)1.93756675
140Elevated erythrocyte sedimentation rate (HP:0003565)1.92420896
141Papillary thyroid carcinoma (HP:0002895)1.90712867
142Thrombophlebitis (HP:0004418)1.90529172
143Increased circulating renin level (HP:0000848)1.90452197
144Menorrhagia (HP:0000132)1.90288158
145Renal cortical cysts (HP:0000803)1.89935309
146Rickets (HP:0002748)1.89308874
147Hepatocellular necrosis (HP:0001404)1.88960999
148Acanthocytosis (HP:0001927)1.88209809
149Elevated hepatic transaminases (HP:0002910)1.87706698
150Increased intramyocellular lipid droplets (HP:0012240)1.86469936
151Metaphyseal dysplasia (HP:0100255)1.86176682
152Abnormality of polysaccharide metabolism (HP:0011012)1.85844588
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85844588
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85844588
155Absent speech (HP:0001344)1.85215708
156Memory impairment (HP:0002354)1.85086762
157Increased neuronal autofluorescent lipopigment (HP:0002074)1.84959272
158Myocardial infarction (HP:0001658)1.84353971
159Abnormal enzyme/coenzyme activity (HP:0012379)1.84304948
160Tubulointerstitial nephritis (HP:0001970)1.84203976
161Amyloidosis (HP:0011034)1.84031114
162Impulsivity (HP:0100710)1.83727801
163Progressive neurologic deterioration (HP:0002344)1.82719602
164Median cleft lip (HP:0000161)1.81775738
165Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81558464
166Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81077026
167Nephrolithiasis (HP:0000787)1.80376501
168Dementia (HP:0000726)1.80156623
169Petechiae (HP:0000967)1.80057679
170Chronic obstructive pulmonary disease (HP:0006510)1.79639827
171Obstructive lung disease (HP:0006536)1.79639827
172Premature ovarian failure (HP:0008209)1.76982263
173Abnormality of midbrain morphology (HP:0002418)1.75757806
174Molar tooth sign on MRI (HP:0002419)1.75757806
175Episodic fever (HP:0001954)1.75730714
176Supranuclear gaze palsy (HP:0000605)1.71911136
177Prostate neoplasm (HP:0100787)1.71818021
178Neuronal loss in central nervous system (HP:0002529)1.71814772
179Dysdiadochokinesis (HP:0002075)1.71147109
180Short tibia (HP:0005736)1.70732100
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.69290346
182Severe visual impairment (HP:0001141)1.68492368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.25736025
2ARAF4.93258643
3ERN13.89407405
4MAP3K93.22109971
5FGFR43.04025232
6MOS2.54296115
7OXSR12.36332287
8SIK12.28854963
9TAOK32.26139348
10WNK32.23233966
11GRK62.21718857
12MAP2K42.15321587
13WNK42.14791542
14MAP3K121.90278827
15EPHA41.88295982
16BRAF1.78712847
17FLT31.77455639
18INSRR1.76663966
19MST1R1.72674311
20RAF11.70224772
21NTRK21.69634161
22NUAK11.67168626
23MAPK131.66860402
24IRAK11.59520152
25IRAK21.57074499
26ERBB41.56272651
27TNK21.53393843
28ABL21.52726007
29MYLK1.51919179
30MAPK111.51095760
31KSR21.50472497
32MAP2K31.46775073
33MAP3K111.45463095
34PINK11.45359498
35PDK31.42913749
36PDK41.42913749
37STK161.41719311
38KDR1.37547874
39DAPK11.33955673
40MAP3K141.33752305
41PIK3CG1.33661516
42TBK11.31997054
43TAOK11.29512020
44MAP2K61.28994222
45DAPK21.28797605
46RIPK41.26619220
47KIT1.26383299
48TYK21.26146589
49NEK61.22591188
50PKN21.14445367
51MAP3K71.12682035
52TIE11.12199209
53NTRK31.11308776
54MARK31.11214942
55MAPK41.10768955
56PRKAA21.10664690
57IKBKB1.10382693
58GRK51.07652589
59EIF2AK11.05247048
60MAP4K11.04210095
61NEK11.02955451
62CSF1R1.01500138
63MARK11.00792826
64ADRBK20.99627385
65PIM20.98657224
66SYK0.95367579
67PKN10.94718387
68CAMKK20.94709552
69TESK20.94462241
70MAPK70.93615381
71BTK0.93030340
72MAP2K70.91882935
73MAPK120.91613973
74CDK90.90145372
75TRIB30.89575311
76NME20.88397327
77MUSK0.87120583
78MAP3K60.86911805
79NEK90.86133249
80AURKA0.86049653
81JAK20.85797832
82CDK190.85366253
83TEC0.82923503
84TXK0.82139736
85CSNK1G30.80927676
86BLK0.80238841
87TAOK20.79514196
88STK240.79018406
89PIM10.77506766
90IRAK40.77504445
91PRKCI0.77467285
92IKBKE0.71772476
93MAP3K50.71566593
94ACVR1B0.71326251
95CSNK1G20.70024393
96CSNK1G10.69503813
97KSR10.69092667
98PRKACG0.68138835
99SGK20.67190685
100TLK10.66799624
101MAP3K30.66035284
102PRKG10.65051375
103TGFBR20.64081273
104SIK30.63692586
105CDK50.61143779
106PRKCZ0.59799240
107EIF2AK30.59701784
108IRAK30.59311847
109SGK4940.59086272
110SGK2230.59086272
111JAK10.58556742
112VRK10.57986699
113ZAP700.57708686
114PRKCG0.54104069
115CAMK2A0.53399789
116PDK20.53325453
117TESK10.51788177
118CSNK1A1L0.51781895
119LYN0.51429211
120PRKCQ0.51250728
121PRKAA10.49935973
122MATK0.48761698
123BMPR20.48222117
124CAMK2G0.47511353
125PDPK10.47071700
126PRKCD0.46641302
127SGK30.46194768
128FRK0.44796454
129GSK3A0.44786452
130PDK10.44514290
131CCNB10.44082135
132TNIK0.43965785
133PRPF4B0.42659556
134FES0.42115289
135PRKD30.42003850
136CASK0.40613499
137PTK2B0.40128406
138DMPK0.39763653
139PRKG20.39293396
140MAP3K130.38568678
141STK38L0.38281483
142GRK70.38139221
143LIMK10.38134298
144PRKCA0.36846309
145CAMK40.32264151
146IGF1R0.31606519
147MAP3K40.31388424
148CSK0.30769892
149MAP3K10.30628227
150PRKACA0.29851882

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00381088
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39945143
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25072385
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.85974595
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74900250
6Arginine biosynthesis_Homo sapiens_hsa002202.72830851
7Nitrogen metabolism_Homo sapiens_hsa009102.68502055
8Tryptophan metabolism_Homo sapiens_hsa003802.66432138
9Fatty acid degradation_Homo sapiens_hsa000712.64834657
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52200361
11Butanoate metabolism_Homo sapiens_hsa006502.51087097
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49044146
13Propanoate metabolism_Homo sapiens_hsa006402.40538893
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40117728
15Peroxisome_Homo sapiens_hsa041462.35184327
16Complement and coagulation cascades_Homo sapiens_hsa046102.17338544
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09728306
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09713655
19Basal transcription factors_Homo sapiens_hsa030222.00597938
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97191985
21Dorso-ventral axis formation_Homo sapiens_hsa043201.92274340
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88358326
23beta-Alanine metabolism_Homo sapiens_hsa004101.88310775
24Fatty acid metabolism_Homo sapiens_hsa012121.86196189
25Histidine metabolism_Homo sapiens_hsa003401.80627008
26Osteoclast differentiation_Homo sapiens_hsa043801.79438124
27Chemical carcinogenesis_Homo sapiens_hsa052041.78514079
28Ovarian steroidogenesis_Homo sapiens_hsa049131.78453472
29PPAR signaling pathway_Homo sapiens_hsa033201.78295746
30Pyruvate metabolism_Homo sapiens_hsa006201.77766375
31Morphine addiction_Homo sapiens_hsa050321.74403032
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73173640
33Asthma_Homo sapiens_hsa053101.70275614
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.67415697
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.65697240
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65054603
37Caffeine metabolism_Homo sapiens_hsa002321.60502242
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58192961
39Nicotine addiction_Homo sapiens_hsa050331.57114454
40Sulfur metabolism_Homo sapiens_hsa009201.56749773
41Rheumatoid arthritis_Homo sapiens_hsa053231.56089750
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.51869951
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48928295
44Retinol metabolism_Homo sapiens_hsa008301.47889007
45Carbon metabolism_Homo sapiens_hsa012001.46336081
46Phenylalanine metabolism_Homo sapiens_hsa003601.45989271
47Staphylococcus aureus infection_Homo sapiens_hsa051501.44358465
48Bile secretion_Homo sapiens_hsa049761.43282435
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.42931794
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42163999
51Selenocompound metabolism_Homo sapiens_hsa004501.41981705
52Leishmaniasis_Homo sapiens_hsa051401.41411897
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38539905
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37279116
55Fatty acid elongation_Homo sapiens_hsa000621.34334015
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.34039882
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33493938
58Starch and sucrose metabolism_Homo sapiens_hsa005001.32735193
59GABAergic synapse_Homo sapiens_hsa047271.32186830
60Biosynthesis of amino acids_Homo sapiens_hsa012301.28940469
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26303858
62Folate biosynthesis_Homo sapiens_hsa007901.24357136
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23596869
64Olfactory transduction_Homo sapiens_hsa047401.23078319
65Tyrosine metabolism_Homo sapiens_hsa003501.18718029
66Lysosome_Homo sapiens_hsa041421.15970591
67Allograft rejection_Homo sapiens_hsa053301.13697358
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12598336
69Tuberculosis_Homo sapiens_hsa051521.12093345
70Sulfur relay system_Homo sapiens_hsa041221.09522548
71Phagosome_Homo sapiens_hsa041451.09016180
72Long-term depression_Homo sapiens_hsa047301.04261932
73Synaptic vesicle cycle_Homo sapiens_hsa047211.03717731
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03686225
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02264260
76Arginine and proline metabolism_Homo sapiens_hsa003301.01189035
77Vitamin digestion and absorption_Homo sapiens_hsa049771.00783325
78Pertussis_Homo sapiens_hsa051331.00608665
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96592186
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96396084
81B cell receptor signaling pathway_Homo sapiens_hsa046620.95667858
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95004039
83ABC transporters_Homo sapiens_hsa020100.94675923
84Fat digestion and absorption_Homo sapiens_hsa049750.93854484
85Glutamatergic synapse_Homo sapiens_hsa047240.90949557
86Glutathione metabolism_Homo sapiens_hsa004800.89887401
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89053494
88Circadian entrainment_Homo sapiens_hsa047130.88397657
89Taste transduction_Homo sapiens_hsa047420.87858717
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86591554
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86373110
92Influenza A_Homo sapiens_hsa051640.79943523
93Autoimmune thyroid disease_Homo sapiens_hsa053200.77970220
94Pentose phosphate pathway_Homo sapiens_hsa000300.77885248
95Glycerolipid metabolism_Homo sapiens_hsa005610.77711460
96Phototransduction_Homo sapiens_hsa047440.77111960
97Graft-versus-host disease_Homo sapiens_hsa053320.76670045
98Chemokine signaling pathway_Homo sapiens_hsa040620.76357125
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.74417803
100Serotonergic synapse_Homo sapiens_hsa047260.74135318
101Steroid biosynthesis_Homo sapiens_hsa001000.74113630
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73921148
103Legionellosis_Homo sapiens_hsa051340.68158447
104Gap junction_Homo sapiens_hsa045400.67766882
105Oocyte meiosis_Homo sapiens_hsa041140.67473347
106Lysine degradation_Homo sapiens_hsa003100.66369748
107TNF signaling pathway_Homo sapiens_hsa046680.66106745
108Salivary secretion_Homo sapiens_hsa049700.65402699
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64696394
110Hematopoietic cell lineage_Homo sapiens_hsa046400.64479143
111Dopaminergic synapse_Homo sapiens_hsa047280.64417699
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64126570
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61942445
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.61270547
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60940544
116Metabolic pathways_Homo sapiens_hsa011000.60677845
117Fructose and mannose metabolism_Homo sapiens_hsa000510.60495246
118Herpes simplex infection_Homo sapiens_hsa051680.56797424
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56489244
120Sphingolipid metabolism_Homo sapiens_hsa006000.55006415
121Malaria_Homo sapiens_hsa051440.53505501
122Vitamin B6 metabolism_Homo sapiens_hsa007500.53238745
123One carbon pool by folate_Homo sapiens_hsa006700.51086889
124Oxidative phosphorylation_Homo sapiens_hsa001900.50249317
125Oxytocin signaling pathway_Homo sapiens_hsa049210.49692522
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49219593
127Amphetamine addiction_Homo sapiens_hsa050310.48114528
128Renin secretion_Homo sapiens_hsa049240.47843613
129Toxoplasmosis_Homo sapiens_hsa051450.47368683
130Type I diabetes mellitus_Homo sapiens_hsa049400.45714890
131Antigen processing and presentation_Homo sapiens_hsa046120.44705720
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.44595200
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39533653
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38015153
135Galactose metabolism_Homo sapiens_hsa000520.35415886
136Parkinsons disease_Homo sapiens_hsa050120.32384320
137Fatty acid biosynthesis_Homo sapiens_hsa000610.22615552
138Alzheimers disease_Homo sapiens_hsa050100.20966412
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.13532711
140Insulin resistance_Homo sapiens_hsa049310.08803216
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06036773
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04055096
143Collecting duct acid secretion_Homo sapiens_hsa049660.03848742
144Glucagon signaling pathway_Homo sapiens_hsa049220.03331320
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03304491
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01280755
147Prion diseases_Homo sapiens_hsa050200.00732391
148Insulin signaling pathway_Homo sapiens_hsa04910-0.1936509
149Pyrimidine metabolism_Homo sapiens_hsa00240-0.1623405
150Mineral absorption_Homo sapiens_hsa04978-0.1461528
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1449360
152Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1326993
153African trypanosomiasis_Homo sapiens_hsa05143-0.1181987
154Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1098253
155Regulation of autophagy_Homo sapiens_hsa04140-0.1096859
156AMPK signaling pathway_Homo sapiens_hsa04152-0.1033565
157Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0931838
158Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0660920
159Linoleic acid metabolism_Homo sapiens_hsa00591-0.0502723
160Renin-angiotensin system_Homo sapiens_hsa04614-0.0436167
161Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0393931
162Other glycan degradation_Homo sapiens_hsa00511-0.0288427
163Huntingtons disease_Homo sapiens_hsa05016-0.0273027
164Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0080450

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