MSRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.28432777
2sarcomere organization (GO:0045214)5.18909651
3cardiac myofibril assembly (GO:0055003)5.12724473
4muscle filament sliding (GO:0030049)5.05023828
5actin-myosin filament sliding (GO:0033275)5.05023828
6collagen fibril organization (GO:0030199)4.66587414
7regulation of skeletal muscle contraction (GO:0014819)4.60121166
8actin-mediated cell contraction (GO:0070252)4.53982806
9myofibril assembly (GO:0030239)4.52128727
10extracellular fibril organization (GO:0043206)4.48899524
11chondrocyte proliferation (GO:0035988)4.37095732
12protein heterotrimerization (GO:0070208)4.35205229
13vascular endothelial growth factor signaling pathway (GO:0038084)4.29982620
14endothelium development (GO:0003158)4.09784663
15blood vessel maturation (GO:0001955)4.07951882
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.97200253
17fibril organization (GO:0097435)3.91223735
18actomyosin structure organization (GO:0031032)3.90446401
19sequestering of extracellular ligand from receptor (GO:0035581)3.77871820
20actin filament-based movement (GO:0030048)3.75990933
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.75092664
22negative regulation of smooth muscle cell migration (GO:0014912)3.73911960
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.73614542
24glomerular basement membrane development (GO:0032836)3.73153503
25negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.69265271
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.67988839
27regulation of integrin-mediated signaling pathway (GO:2001044)3.64127829
28endodermal cell differentiation (GO:0035987)3.63212746
29cardiac muscle cell development (GO:0055013)3.59171239
30heart trabecula formation (GO:0060347)3.58807959
31cell adhesion mediated by integrin (GO:0033627)3.47608435
32basement membrane organization (GO:0071711)3.46745476
33cardiac cell development (GO:0055006)3.46036878
34negative regulation of fatty acid transport (GO:2000192)3.45928621
35peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.43743708
36mesenchymal-epithelial cell signaling (GO:0060638)3.43140588
37epithelial cell-cell adhesion (GO:0090136)3.41906741
38regulation of tight junction assembly (GO:2000810)3.40215724
39skin morphogenesis (GO:0043589)3.38618951
40definitive hemopoiesis (GO:0060216)3.37041424
41carnitine shuttle (GO:0006853)3.34401977
42regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.31669219
43relaxation of smooth muscle (GO:0044557)3.31254731
44glomerular filtration (GO:0003094)3.31020556
45negative regulation of nitric-oxide synthase activity (GO:0051001)3.30941224
46negative regulation of nitric oxide biosynthetic process (GO:0045019)3.27738338
47lymph vessel development (GO:0001945)3.25795030
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.25523608
49axon extension involved in axon guidance (GO:0048846)3.25523608
50regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.25044272
51cell migration involved in sprouting angiogenesis (GO:0002042)3.24837536
52trabecula formation (GO:0060343)3.23087574
53renal filtration (GO:0097205)3.21844740
54cell migration involved in heart development (GO:0060973)3.18504645
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18110412
56keratan sulfate catabolic process (GO:0042340)3.16210836
57type B pancreatic cell proliferation (GO:0044342)3.14952761
58cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.12717083
59regulation of the force of heart contraction (GO:0002026)3.09960948
60fatty acid transmembrane transport (GO:1902001)3.09066627
61smooth muscle tissue development (GO:0048745)3.08640475
62endocardial cushion development (GO:0003197)3.07975716
63bone trabecula formation (GO:0060346)3.07625953
64cardiac muscle tissue morphogenesis (GO:0055008)3.06869221
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.06294601
66negative regulation of protein localization to cell surface (GO:2000009)3.05658486
67negative regulation of potassium ion transmembrane transport (GO:1901380)3.05187856
68negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.04331090
69metanephric mesenchyme development (GO:0072075)3.02142777
70protein hydroxylation (GO:0018126)3.01215167
71atrioventricular valve morphogenesis (GO:0003181)3.00757750
72wound healing, spreading of epidermal cells (GO:0035313)3.00583554
73positive regulation of endothelial cell apoptotic process (GO:2000353)3.00454067
74glomerular visceral epithelial cell development (GO:0072015)3.00170102
75cardiac muscle contraction (GO:0060048)2.99890019
76collagen metabolic process (GO:0032963)2.98687986
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.97600784
78peptidyl-proline hydroxylation (GO:0019511)2.94839928
79muscle tissue morphogenesis (GO:0060415)2.94761364
80regulation of relaxation of muscle (GO:1901077)2.93354549
81atrial septum morphogenesis (GO:0060413)2.91806908
82endothelial cell morphogenesis (GO:0001886)2.90024544
83positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.89152361
84pericardium development (GO:0060039)2.87150827
85cellular response to vitamin (GO:0071295)2.86718682
86collagen catabolic process (GO:0030574)2.86568840
87apoptotic cell clearance (GO:0043277)2.85494010
88negative regulation of heart growth (GO:0061117)2.85464265
89negative regulation of cardiac muscle tissue growth (GO:0055022)2.85464265
90negative regulation of calcium ion transmembrane transport (GO:1903170)2.85024858
91negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.85024858
92ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.84615104
93positive regulation of vasculogenesis (GO:2001214)2.84403661
94regulation of muscle contraction (GO:0006937)2.83634007
95multicellular organismal macromolecule metabolic process (GO:0044259)2.83494478
96regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83441513
97skeletal muscle tissue development (GO:0007519)2.83110961
98angiogenesis involved in wound healing (GO:0060055)2.81272560
99kidney mesenchyme development (GO:0072074)2.80396769
100cell-substrate junction assembly (GO:0007044)2.80325805
101stress fiber assembly (GO:0043149)2.78588532
102fibroblast migration (GO:0010761)2.76191876
103protein localization to cell surface (GO:0034394)2.76117135
104dermatan sulfate biosynthetic process (GO:0030208)2.75385423
105bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75220817
106regulation of cardioblast differentiation (GO:0051890)2.75012858
107positive regulation of myoblast differentiation (GO:0045663)2.74798746
108muscle system process (GO:0003012)2.74374527
109relaxation of muscle (GO:0090075)2.74020462
110actin filament depolymerization (GO:0030042)2.73959635
111activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.73413310
112positive regulation of blood vessel endothelial cell migration (GO:0043536)2.72098650
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.71415674
114hippo signaling (GO:0035329)2.70959122
115regulation of muscle system process (GO:0090257)2.70467412
116dermatan sulfate metabolic process (GO:0030205)2.70041602
117multicellular organismal metabolic process (GO:0044236)2.69297280
118regulation of actin filament-based movement (GO:1903115)2.68288039
119regulation of striated muscle contraction (GO:0006942)2.66984747
120lymphangiogenesis (GO:0001946)2.65814715
121sprouting angiogenesis (GO:0002040)2.65413733
122ventricular cardiac muscle cell development (GO:0055015)2.65394485
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65240729
124cardiac muscle hypertrophy (GO:0003300)2.65109231
125multicellular organismal catabolic process (GO:0044243)2.64483401
126blood vessel endothelial cell migration (GO:0043534)2.64306698
127substrate adhesion-dependent cell spreading (GO:0034446)2.63533746
128vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.63032844
129extracellular matrix assembly (GO:0085029)2.62974553
130heparin metabolic process (GO:0030202)2.62749101
131heparin biosynthetic process (GO:0030210)2.62749101
132venous blood vessel morphogenesis (GO:0048845)2.62326627
133positive regulation of fatty acid oxidation (GO:0046321)2.61543567
134extracellular matrix disassembly (GO:0022617)2.60694952
135negative regulation of striated muscle cell apoptotic process (GO:0010664)2.60503457
136positive regulation of fatty acid beta-oxidation (GO:0032000)2.60146343
137muscle contraction (GO:0006936)2.60077909
138regulation of cell communication by electrical coupling (GO:0010649)2.59945414
139glomerular epithelial cell development (GO:0072310)2.59860255
140desmosome organization (GO:0002934)2.59277898
141hypotonic response (GO:0006971)2.57327631
142barbed-end actin filament capping (GO:0051016)2.57242534
143striated muscle hypertrophy (GO:0014897)2.56580527
144regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.56002560
145muscle tissue development (GO:0060537)2.55468819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.60361605
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.28673495
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.82116003
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.43091169
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.39528448
6CLOCK_20551151_ChIP-Seq_293T_Human3.08749019
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86401485
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.67288580
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.61114349
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.60812362
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57706275
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.54605792
13CJUN_26792858_Chip-Seq_BT549_Human2.50052255
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.41529146
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.40399512
16TBX20_22328084_ChIP-Seq_HEART_Mouse2.40399512
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33004683
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32450005
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21512521
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.20999978
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.20506929
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.15286131
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12387034
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.04498943
25PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00972503
26* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.90818180
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.88468733
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.83264899
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.83264899
30* BRD4_25478319_ChIP-Seq_HGPS_Human1.80859531
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79756023
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76283159
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.73690836
34* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72444699
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.71220785
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.68049937
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60032716
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58903410
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58903410
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56311755
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54902682
42JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49471413
43TP53_16413492_ChIP-PET_HCT116_Human1.48275932
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.48165887
45* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47669831
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46678051
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46247472
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.45967393
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44950841
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44599238
51NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.42658747
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39540160
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39186405
54TP53_18474530_ChIP-ChIP_U2OS_Human1.37432803
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.37127758
56SMC1_22415368_ChIP-Seq_MEFs_Mouse1.35399464
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33892733
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33726835
59GBX2_23144817_ChIP-Seq_PC3_Human1.30201747
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30195343
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.22294437
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20772416
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.20082546
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19264113
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18472533
66* ISL1_27105846_Chip-Seq_CPCs_Mouse1.17484820
67GATA4_21415370_ChIP-Seq_HL-1_Mouse1.16995069
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15986088
69* SOX2_20726797_ChIP-Seq_SW620_Human1.14757201
70* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14646480
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12486360
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12234753
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12043237
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11113772
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.10655043
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09455141
77ATF3_27146783_Chip-Seq_COLON_Human1.07846756
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06995954
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06182959
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05850749
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05582296
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05519379
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.04484739
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03683617
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03683617
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.02749704
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02560453
88BCAT_22108803_ChIP-Seq_LS180_Human1.01613887
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01543842
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00935851
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00715490
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00073876
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99653802
94* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99194713
95TP53_22127205_ChIP-Seq_IMR90_Human0.98450662
96* SMAD4_21799915_ChIP-Seq_A2780_Human0.97430470
97* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.97293667
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96660612
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.96476137
100PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.96383964
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96277346
102SCL_19346495_ChIP-Seq_HPC-7_Human0.96019324
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95456227
104TP63_23658742_ChIP-Seq_EP156T_Human0.94369712
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.91918229
106* VDR_24787735_ChIP-Seq_THP-1_Human0.91908937
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91640024
108AHR_22903824_ChIP-Seq_MCF-7_Human0.91567600
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91489205
110SA1_22415368_ChIP-Seq_MEFs_Mouse0.90989046
111* RACK7_27058665_Chip-Seq_MCF-7_Human0.90840097
112EED_16625203_ChIP-ChIP_MESCs_Mouse0.90716282
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90464446
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90163412
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89380087
116GATA1_19941826_ChIP-Seq_K562_Human0.88128792
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88101128
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87955536
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87519814
120* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87249064
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86538983
122* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86012083
123NFI_21473784_ChIP-Seq_ESCs_Mouse0.85990685
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85928453
125* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85510471
126* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84025277
127RXR_22108803_ChIP-Seq_LS180_Human0.84013540
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.83349573
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81292519
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80978323
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80972381
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79767729
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79733506
134* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79193576
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78898700
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78803329
137NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78360728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.86467846
2MP0005275_abnormal_skin_tensile3.96370417
3MP0005503_abnormal_tendon_morphology3.44164022
4MP0003705_abnormal_hypodermis_morpholog3.35015309
5MP0003279_aneurysm3.31012532
6MP0002837_dystrophic_cardiac_calcinosis3.26069479
7MP0004084_abnormal_cardiac_muscle3.13359388
8MP0000751_myopathy3.07633593
9MP0004272_abnormal_basement_membrane2.67831769
10MP0000749_muscle_degeneration2.55523270
11MP0001958_emphysema2.48641870
12MP0005623_abnormal_meninges_morphology2.44621907
13MP0004036_abnormal_muscle_relaxation2.39329115
14MP0009384_cardiac_valve_regurgitation2.39112676
15MP0005330_cardiomyopathy2.23086682
16MP0010368_abnormal_lymphatic_system2.14136701
17MP0004087_abnormal_muscle_fiber2.10594927
18MP0000750_abnormal_muscle_regeneration2.09804291
19MP0003646_muscle_fatigue2.08375746
20MP0003566_abnormal_cell_adhesion2.04404961
21MP0004215_abnormal_myocardial_fiber1.98651119
22MP0005620_abnormal_muscle_contractility1.91411989
23MP0004130_abnormal_muscle_cell1.79593385
24MP0006138_congestive_heart_failure1.79291947
25MP0002972_abnormal_cardiac_muscle1.78500693
26MP0001879_abnormal_lymphatic_vessel1.75061157
27MP0010630_abnormal_cardiac_muscle1.73995133
28MP0008775_abnormal_heart_ventricle1.72938199
29MP0004145_abnormal_muscle_electrophysio1.68098398
30MP0003828_pulmonary_edema1.67478293
31MP0005385_cardiovascular_system_phenoty1.61031578
32MP0001544_abnormal_cardiovascular_syste1.61031578
33MP0000013_abnormal_adipose_tissue1.60772595
34MP0002108_abnormal_muscle_morphology1.60447145
35MP0000733_abnormal_muscle_development1.59886450
36MP0000759_abnormal_skeletal_muscle1.58522294
37MP0000767_abnormal_smooth_muscle1.57095975
38MP0002106_abnormal_muscle_physiology1.54813709
39MP0006054_spinal_hemorrhage1.51470565
40MP0003091_abnormal_cell_migration1.51083857
41MP0002295_abnormal_pulmonary_circulatio1.48422460
42MP0005369_muscle_phenotype1.48254649
43MP0004484_altered_response_of1.47498652
44MP0003950_abnormal_plasma_membrane1.45832963
45MP0005023_abnormal_wound_healing1.43977527
46MP0005508_abnormal_skeleton_morphology1.43305983
47MP0009250_abnormal_appendicular_skeleto1.40153296
48MP0002269_muscular_atrophy1.38553440
49MP0005670_abnormal_white_adipose1.37300930
50MP0000747_muscle_weakness1.34795814
51MP0002060_abnormal_skin_morphology1.34271282
52MP0005666_abnormal_adipose_tissue1.31774714
53MP0010352_gastrointestinal_tract_polyps1.30488036
54MP0003385_abnormal_body_wall1.27206511
55MP0004185_abnormal_adipocyte_glucose1.22676093
56MP0005464_abnormal_platelet_physiology1.18312411
57MP0002128_abnormal_blood_circulation1.17269137
58MP0010386_abnormal_urinary_bladder1.16761008
59MP0004233_abnormal_muscle_weight1.16552034
60MP0003045_fibrosis1.15315563
61MP0009780_abnormal_chondrocyte_physiolo1.15101377
62MP0005375_adipose_tissue_phenotype1.13877302
63MP0000230_abnormal_systemic_arterial1.13627303
64MP0010030_abnormal_orbit_morphology1.10869204
65MP0002896_abnormal_bone_mineralization1.09985686
66MP0003137_abnormal_impulse_conducting1.09465771
67MP0003283_abnormal_digestive_organ1.08709292
68MP0000003_abnormal_adipose_tissue1.07060375
69MP0005171_absent_coat_pigmentation1.03814968
70MP0001299_abnormal_eye_distance/0.99746280
71MP0004134_abnormal_chest_morphology0.99551415
72MP0000343_altered_response_to0.99415523
73MP0001542_abnormal_bone_strength0.99217591
74MP0001661_extended_life_span0.97609828
75MP0000266_abnormal_heart_morphology0.96549949
76MP0005257_abnormal_intraocular_pressure0.95633823
77MP0002282_abnormal_trachea_morphology0.94365582
78MP0009053_abnormal_anal_canal0.94347088
79MP0004085_abnormal_heartbeat0.90093426
80MP0001614_abnormal_blood_vessel0.88583319
81MP0002127_abnormal_cardiovascular_syste0.88244440
82MP0000163_abnormal_cartilage_morphology0.88223693
83MP0002877_abnormal_melanocyte_morpholog0.87384869
84MP0002168_other_aberrant_phenotype0.85767074
85MP0001243_abnormal_dermal_layer0.85518182
86MP0002925_abnormal_cardiovascular_devel0.85306581
87MP0000534_abnormal_ureter_morphology0.84466806
88MP0000516_abnormal_urinary_system0.83127963
89MP0005367_renal/urinary_system_phenotyp0.83127963
90MP0005595_abnormal_vascular_smooth0.83001664
91MP0002115_abnormal_skeleton_extremities0.80922758
92MP0003567_abnormal_fetal_cardiomyocyte0.79383163
93MP0003300_gastrointestinal_ulcer0.77939204
94MP0005164_abnormal_response_to0.77896805
95MP0003941_abnormal_skin_development0.77857713
96MP0002332_abnormal_exercise_endurance0.77604681
97MP0002933_joint_inflammation0.75439362
98MP0005165_increased_susceptibility_to0.75125246
99MP0002133_abnormal_respiratory_system0.74240114
100MP0005388_respiratory_system_phenotype0.74240114
101MP0002396_abnormal_hematopoietic_system0.74189788
102MP0005390_skeleton_phenotype0.74073697
103MP0005084_abnormal_gallbladder_morpholo0.74061052
104MP0003935_abnormal_craniofacial_develop0.70860309
105MP0000762_abnormal_tongue_morphology0.70305897
106MP0003115_abnormal_respiratory_system0.69963986
107MP0004510_myositis0.69820642
108MP0003942_abnormal_urinary_system0.68325216
109MP0002113_abnormal_skeleton_development0.68297202
110MP0002932_abnormal_joint_morphology0.67219503
111MP0003221_abnormal_cardiomyocyte_apopto0.65380140
112MP0004808_abnormal_hematopoietic_stem0.64166066
113MP0008004_abnormal_stomach_pH0.64101715
114MP0000249_abnormal_blood_vessel0.63245221
115MP0000462_abnormal_digestive_system0.58626059

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.03657535
2Premature rupture of membranes (HP:0001788)5.87104135
3Type 1 muscle fiber predominance (HP:0003803)4.62510235
4Increased connective tissue (HP:0009025)4.61090671
5Aortic dissection (HP:0002647)4.42577471
6Muscle fiber splitting (HP:0003555)4.32220148
7Aortic aneurysm (HP:0004942)4.21528157
8Ankle contracture (HP:0006466)3.84935855
9Hyporeflexia of lower limbs (HP:0002600)3.82667400
10Sudden death (HP:0001699)3.80636497
11Broad metatarsal (HP:0001783)3.73895188
12Right ventricular cardiomyopathy (HP:0011663)3.69678739
13Cerebral aneurysm (HP:0004944)3.62746744
14Ventricular tachycardia (HP:0004756)3.61710942
15Exercise-induced muscle cramps (HP:0003710)3.60422014
16Abnormality of the calf musculature (HP:0001430)3.43113676
17Spondylolisthesis (HP:0003302)3.37522554
18Exercise-induced myalgia (HP:0003738)3.37274200
19Shallow orbits (HP:0000586)3.36989454
20Spinal rigidity (HP:0003306)3.34946030
21Lipoatrophy (HP:0100578)3.31375100
22Calf muscle hypertrophy (HP:0008981)3.30557197
23Atrophic scars (HP:0001075)3.28460496
24Increased variability in muscle fiber diameter (HP:0003557)3.20730566
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.15817791
26Round ear (HP:0100830)3.14806627
27Arterial tortuosity (HP:0005116)3.12777979
28Muscle hypertrophy of the lower extremities (HP:0008968)3.11696353
29Muscle fiber inclusion bodies (HP:0100299)3.11169888
30Atrial fibrillation (HP:0005110)3.09566355
31Peritonitis (HP:0002586)3.06002471
32Neck muscle weakness (HP:0000467)3.03349488
33Soft skin (HP:0000977)2.99720702
34Dilatation of the ascending aorta (HP:0005111)2.97943983
35Abnormality of skeletal muscle fiber size (HP:0012084)2.97765748
36Difficulty running (HP:0009046)2.95350340
37Aortic regurgitation (HP:0001659)2.88882864
38Difficulty climbing stairs (HP:0003551)2.83691140
39Primary atrial arrhythmia (HP:0001692)2.83637338
40EMG: myopathic abnormalities (HP:0003458)2.81735963
41Hypoplastic ischia (HP:0003175)2.78639934
42Fragile skin (HP:0001030)2.77992830
43Abnormality of dentin (HP:0010299)2.76081913
44Supraventricular arrhythmia (HP:0005115)2.75817233
45Cervical subluxation (HP:0003308)2.71689268
46Bladder diverticulum (HP:0000015)2.70818402
47Scapular winging (HP:0003691)2.70074144
48Mildly elevated creatine phosphokinase (HP:0008180)2.69721032
49Supraventricular tachycardia (HP:0004755)2.69032983
50Wrist flexion contracture (HP:0001239)2.65712675
51Abnormality of the left ventricular outflow tract (HP:0011103)2.63413436
52Subaortic stenosis (HP:0001682)2.63413436
53Mitral valve prolapse (HP:0001634)2.63168474
54Wormian bones (HP:0002645)2.60370798
55Nemaline bodies (HP:0003798)2.59623365
56Aneurysm (HP:0002617)2.54451199
57Joint stiffness (HP:0001387)2.51385124
58Abnormality of the ischium (HP:0003174)2.46744870
59Myoglobinuria (HP:0002913)2.46469553
60Follicular hyperkeratosis (HP:0007502)2.45619979
61Neonatal short-limb short stature (HP:0008921)2.45152969
62Blue sclerae (HP:0000592)2.44607649
63Distal lower limb muscle weakness (HP:0009053)2.39004199
64Asymmetric septal hypertrophy (HP:0001670)2.36327758
65Dilated cardiomyopathy (HP:0001644)2.35385844
66Infantile muscular hypotonia (HP:0008947)2.34544996
67Genu recurvatum (HP:0002816)2.34250545
68Distal arthrogryposis (HP:0005684)2.32745823
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.32585075
70Mesomelia (HP:0003027)2.31219063
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29702676
72Hypoplasia of the iris (HP:0007676)2.28693410
73Increased density of long bones (HP:0006392)2.27951613
74Myotonia (HP:0002486)2.27460867
75Vertebral compression fractures (HP:0002953)2.26242806
76Overgrowth (HP:0001548)2.24298251
77Vascular tortuosity (HP:0004948)2.19245968
78Bowel diverticulosis (HP:0005222)2.19243258
79Osteolytic defects of the hand bones (HP:0009699)2.14946777
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.14946777
81Bell-shaped thorax (HP:0001591)2.13725095
82Joint laxity (HP:0001388)2.13361470
83Biconcave vertebral bodies (HP:0004586)2.12460721
84Distal lower limb amyotrophy (HP:0008944)2.12361896
85Hip contracture (HP:0003273)2.10605981
86Slender build (HP:0001533)2.08902094
87Elbow flexion contracture (HP:0002987)2.06130077
88Aortic valve stenosis (HP:0001650)2.05918671
89Mitral regurgitation (HP:0001653)2.02021408
90Limited hip movement (HP:0008800)2.01906926
91Abnormality of the calcaneus (HP:0008364)2.01785794
92Calcaneovalgus deformity (HP:0001848)2.01084591
93Facial diplegia (HP:0001349)1.99428705
94Short hallux (HP:0010109)1.97721260
95Knee flexion contracture (HP:0006380)1.97218357
96Camptodactyly of toe (HP:0001836)1.96770192
97Ventricular arrhythmia (HP:0004308)1.95739106
98Ulnar deviation of the wrist (HP:0003049)1.95128932
99Deformed tarsal bones (HP:0008119)1.94862242
100Bradycardia (HP:0001662)1.94718260
101Rhabdomyolysis (HP:0003201)1.92838578
102Wide anterior fontanel (HP:0000260)1.92507774
103Delayed closure of the anterior fontanelle (HP:0001476)1.92129598
104Venous abnormality (HP:0002624)1.91897770
105Hyperextensible skin (HP:0000974)1.91454186
106Abnormal delivery (HP:0001787)1.90142221
107Short nail (HP:0001799)1.90031522
108Ulnar bowing (HP:0003031)1.89438860
109Abnormality of the acetabulum (HP:0003170)1.89093407
110Broad ribs (HP:0000885)1.88208606
111Absent phalangeal crease (HP:0006109)1.87743559
112Heart block (HP:0012722)1.86737474
113Tarsal synostosis (HP:0008368)1.86625000
114Increased mean platelet volume (HP:0011877)1.86375395
115Ectopia lentis (HP:0001083)1.85338923
116Abnormal atrioventricular conduction (HP:0005150)1.84899657
117Aplasia/Hypoplasia of the hallux (HP:0008362)1.83674701
118Bundle branch block (HP:0011710)1.83657630
119Abnormal finger flexion creases (HP:0006143)1.83025078
120Ovoid vertebral bodies (HP:0003300)1.82445380
121Areflexia of lower limbs (HP:0002522)1.82426260
122Muscular dystrophy (HP:0003560)1.81900734
123Prolonged QT interval (HP:0001657)1.81493601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.91772879
2TRIB33.62868213
3MYLK3.28601301
4DMPK2.89901442
5DDR22.88683714
6OBSCN2.77027288
7KIT2.51487390
8LATS12.50545328
9PDGFRA2.48844620
10PIK3CA2.43632224
11PKN22.41329235
12PDK42.32088764
13PDK32.32088764
14RIPK11.92974867
15TRPM71.90937762
16SIK11.90313964
17TIE11.86515140
18PHKG21.84069610
19PHKG11.84069610
20PDK21.68368317
21EPHB21.68011216
22LMTK21.61573977
23LATS21.58577651
24PAK21.53999910
25PAK31.53740232
26MAP3K61.48775842
27PINK11.46972352
28TGFBR21.46737095
29STK38L1.45917824
30NEK91.39026699
31PIK3CG1.38745113
32ZAK1.35497844
33PTK2B1.34540526
34FER1.31614573
35MAP2K31.27033097
36ROCK11.23473287
37STK241.23384643
38ERN11.22732499
39ILK1.20920637
40KDR1.19615083
41TAOK31.16827635
42MUSK1.16269934
43EPHA31.15873512
44FRK1.15477631
45LRRK21.14155810
46MAP3K31.09707634
47TESK11.09584448
48PTK61.09559885
49TEC1.07996605
50STK31.07848662
51MAPK71.01447313
52PRKD10.97961786
53MAPKAPK30.92564481
54PTK20.92414027
55LIMK10.89293564
56PDGFRB0.89041172
57GRK70.87872321
58SCYL20.87659991
59NUAK10.86799481
60MAP4K20.84290107
61EEF2K0.81493191
62PRKAA20.77454494
63EPHB10.76206831
64PRKG20.76196515
65BMX0.74967429
66CDC42BPA0.74864004
67ZAP700.74498361
68NEK10.73843182
69ERBB30.73472949
70CAMK1D0.71060365
71MTOR0.69300148
72MET0.67869142
73CAMK2G0.67553242
74TBK10.67255455
75MAP2K10.66179638
76AKT30.65182947
77MAP3K70.64667905
78GRK50.64469830
79JAK10.64390513
80MAPK120.64292957
81CDK80.63919295
82MAPK40.63750375
83NTRK10.62402760
84RPS6KA40.62009891
85TGFBR10.60144855
86RPS6KA20.59661594
87PRKD20.56089665
88CAMK10.55693911
89PAK60.54415869
90RPS6KL10.53258069
91RPS6KC10.53258069
92PAK40.52453383
93ROCK20.52135689
94RPS6KA60.51668500
95FGFR20.51074404
96BCKDK0.50819803
97STK100.50709029
98FLT30.50066230
99CAMK1G0.49273215
100DAPK30.48006263
101FGFR10.47867934
102FGFR30.43486347
103MAP3K100.42581095
104WNK10.42525049
105CAMK2D0.42458511
106PRKCH0.42427070
107RET0.42366843
108PIM20.41953931
109PAK10.41469058
110PRKAA10.40250491
111PRKG10.38707688
112ABL10.37216481
113INSR0.37011130
114JAK30.34849533
115MOS0.34089249
116MAP3K50.30168798
117CAMK2A0.29711689
118STK380.29312543
119TAOK10.28297274
120FGFR40.26868319
121GSK3A0.25483570
122PRKD30.25367422
123CDK60.24797035
124WNK40.24702853
125MAPK30.24493356
126ERBB40.23662638
127MAPKAPK20.22024886
128ADRBK10.21122314
129IGF1R0.19609814
130PRKCE0.19579857
131SRC0.18738498
132ABL20.17609717
133PRKACB0.17304637

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.91925515
2Dilated cardiomyopathy_Homo sapiens_hsa054143.71987278
3ECM-receptor interaction_Homo sapiens_hsa045123.62317683
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.22157975
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.09269254
6Focal adhesion_Homo sapiens_hsa045103.01469415
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.10727029
8Adherens junction_Homo sapiens_hsa045202.05890306
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.00917231
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93444965
11Propanoate metabolism_Homo sapiens_hsa006401.91822332
12Proteoglycans in cancer_Homo sapiens_hsa052051.87021207
13Amoebiasis_Homo sapiens_hsa051461.84262561
14Cardiac muscle contraction_Homo sapiens_hsa042601.80742059
15Viral myocarditis_Homo sapiens_hsa054161.80585928
16Fatty acid degradation_Homo sapiens_hsa000711.76763639
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70839063
18Protein digestion and absorption_Homo sapiens_hsa049741.64903020
19Small cell lung cancer_Homo sapiens_hsa052221.60004032
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54348013
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40234487
22Fatty acid metabolism_Homo sapiens_hsa012121.39127573
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37131790
24TGF-beta signaling pathway_Homo sapiens_hsa043501.36861886
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.36591260
26Malaria_Homo sapiens_hsa051441.35824979
27PPAR signaling pathway_Homo sapiens_hsa033201.33944335
28Insulin resistance_Homo sapiens_hsa049311.33549095
29Tight junction_Homo sapiens_hsa045301.28908837
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26266577
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.21640400
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.20056305
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18870233
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.17756210
35Platelet activation_Homo sapiens_hsa046111.16392818
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14701503
37MicroRNAs in cancer_Homo sapiens_hsa052061.13165190
38Hippo signaling pathway_Homo sapiens_hsa043901.11532571
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05800144
40Carbon metabolism_Homo sapiens_hsa012001.04496640
41Bladder cancer_Homo sapiens_hsa052191.03781235
42Salivary secretion_Homo sapiens_hsa049701.03596180
43AMPK signaling pathway_Homo sapiens_hsa041521.03234869
44Glucagon signaling pathway_Homo sapiens_hsa049221.01495220
45Circadian rhythm_Homo sapiens_hsa047100.98518366
46Insulin signaling pathway_Homo sapiens_hsa049100.98307152
47Starch and sucrose metabolism_Homo sapiens_hsa005000.97296239
48HIF-1 signaling pathway_Homo sapiens_hsa040660.93915481
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92003570
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89770723
51Melanoma_Homo sapiens_hsa052180.88156323
52Pyruvate metabolism_Homo sapiens_hsa006200.85303464
53Toxoplasmosis_Homo sapiens_hsa051450.82880797
54Chronic myeloid leukemia_Homo sapiens_hsa052200.82740391
55Rap1 signaling pathway_Homo sapiens_hsa040150.82047951
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81783263
57Oxytocin signaling pathway_Homo sapiens_hsa049210.80187084
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.78015330
59Fatty acid biosynthesis_Homo sapiens_hsa000610.76731357
60Lysine degradation_Homo sapiens_hsa003100.76606263
61Arachidonic acid metabolism_Homo sapiens_hsa005900.74714543
62Basal cell carcinoma_Homo sapiens_hsa052170.72990938
63Renin-angiotensin system_Homo sapiens_hsa046140.71985380
64Pathways in cancer_Homo sapiens_hsa052000.71794602
65Circadian entrainment_Homo sapiens_hsa047130.71656009
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70651870
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.65675544
68Long-term depression_Homo sapiens_hsa047300.65341726
69Pentose phosphate pathway_Homo sapiens_hsa000300.64332331
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62414933
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62316465
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61421023
73Renal cell carcinoma_Homo sapiens_hsa052110.60658382
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59578400
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59573236
76Ovarian steroidogenesis_Homo sapiens_hsa049130.58359980
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57574629
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57553963
79Renin secretion_Homo sapiens_hsa049240.56477125
80FoxO signaling pathway_Homo sapiens_hsa040680.55512951
81Pancreatic secretion_Homo sapiens_hsa049720.55212112
82Sulfur metabolism_Homo sapiens_hsa009200.54616408
83Pancreatic cancer_Homo sapiens_hsa052120.53956116
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53405751
85VEGF signaling pathway_Homo sapiens_hsa043700.53353991
86beta-Alanine metabolism_Homo sapiens_hsa004100.52944775
87Prostate cancer_Homo sapiens_hsa052150.52286079
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51274682
89HTLV-I infection_Homo sapiens_hsa051660.49717530
90Axon guidance_Homo sapiens_hsa043600.49174927
91Shigellosis_Homo sapiens_hsa051310.49096140
92Dorso-ventral axis formation_Homo sapiens_hsa043200.48256316
93TNF signaling pathway_Homo sapiens_hsa046680.47964273
94Pertussis_Homo sapiens_hsa051330.47391125
95Glioma_Homo sapiens_hsa052140.46529783
96mTOR signaling pathway_Homo sapiens_hsa041500.46320548
97Gastric acid secretion_Homo sapiens_hsa049710.46250414
98Salmonella infection_Homo sapiens_hsa051320.46125375
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45473740
100Hedgehog signaling pathway_Homo sapiens_hsa043400.45468878
101Caffeine metabolism_Homo sapiens_hsa002320.45185207
102Other glycan degradation_Homo sapiens_hsa005110.44219641
103Tyrosine metabolism_Homo sapiens_hsa003500.43746525
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43685724
105Fatty acid elongation_Homo sapiens_hsa000620.42782350
106MAPK signaling pathway_Homo sapiens_hsa040100.42423109
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42348249
108Glutathione metabolism_Homo sapiens_hsa004800.42052890
109Wnt signaling pathway_Homo sapiens_hsa043100.41020196
110Gap junction_Homo sapiens_hsa045400.39056382
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38812336
112Tryptophan metabolism_Homo sapiens_hsa003800.38182946
113Cholinergic synapse_Homo sapiens_hsa047250.38082083
114Notch signaling pathway_Homo sapiens_hsa043300.38029664
115Complement and coagulation cascades_Homo sapiens_hsa046100.36854120
116Olfactory transduction_Homo sapiens_hsa047400.36697635
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35310470
118p53 signaling pathway_Homo sapiens_hsa041150.34698172
119Calcium signaling pathway_Homo sapiens_hsa040200.33765550
120Serotonergic synapse_Homo sapiens_hsa047260.33404464
121Arginine and proline metabolism_Homo sapiens_hsa003300.33096909
122cAMP signaling pathway_Homo sapiens_hsa040240.32924194
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31096106
124GnRH signaling pathway_Homo sapiens_hsa049120.30734990
125Ras signaling pathway_Homo sapiens_hsa040140.30409391
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28716861
127Melanogenesis_Homo sapiens_hsa049160.28243207
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27781298
129Osteoclast differentiation_Homo sapiens_hsa043800.27484192
130Estrogen signaling pathway_Homo sapiens_hsa049150.26432413
131Acute myeloid leukemia_Homo sapiens_hsa052210.24113962
132Endocytosis_Homo sapiens_hsa041440.20983890

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