MST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.63272803
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63272803
3L-phenylalanine metabolic process (GO:0006558)7.28818277
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28818277
5aromatic amino acid family catabolic process (GO:0009074)6.84300313
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.38306561
7tryptophan catabolic process (GO:0006569)6.20614562
8indole-containing compound catabolic process (GO:0042436)6.20614562
9indolalkylamine catabolic process (GO:0046218)6.20614562
10kynurenine metabolic process (GO:0070189)6.08020850
11epoxygenase P450 pathway (GO:0019373)6.07597706
12regulation of plasminogen activation (GO:0010755)5.97971897
13bile acid biosynthetic process (GO:0006699)5.95747743
14exogenous drug catabolic process (GO:0042738)5.95543754
15tryptophan metabolic process (GO:0006568)5.83780241
16glyoxylate metabolic process (GO:0046487)5.81404093
17urea metabolic process (GO:0019627)5.74024443
18urea cycle (GO:0000050)5.74024443
19negative regulation of fibrinolysis (GO:0051918)5.71278341
20high-density lipoprotein particle remodeling (GO:0034375)5.62482004
21alpha-linolenic acid metabolic process (GO:0036109)5.58922587
22intestinal cholesterol absorption (GO:0030299)5.58194018
23regulation of fibrinolysis (GO:0051917)5.53218114
24omega-hydroxylase P450 pathway (GO:0097267)5.52004270
25regulation of protein activation cascade (GO:2000257)5.46055757
26protein carboxylation (GO:0018214)5.45403286
27peptidyl-glutamic acid carboxylation (GO:0017187)5.45403286
28complement activation, alternative pathway (GO:0006957)5.40636525
29cysteine metabolic process (GO:0006534)5.36135002
30sulfur amino acid catabolic process (GO:0000098)5.33731813
31nitrogen cycle metabolic process (GO:0071941)5.27147467
32serine family amino acid catabolic process (GO:0009071)5.13215740
33bile acid metabolic process (GO:0008206)5.09407052
34regulation of complement activation (GO:0030449)5.07757402
35aromatic amino acid family metabolic process (GO:0009072)4.96514600
36reverse cholesterol transport (GO:0043691)4.93511941
37regulation of cholesterol esterification (GO:0010872)4.88776533
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86860221
39regulation of triglyceride catabolic process (GO:0010896)4.84922981
40plasma lipoprotein particle remodeling (GO:0034369)4.82624782
41protein-lipid complex remodeling (GO:0034368)4.82624782
42macromolecular complex remodeling (GO:0034367)4.82624782
43tyrosine metabolic process (GO:0006570)4.82512216
44homocysteine metabolic process (GO:0050667)4.76695115
45acute-phase response (GO:0006953)4.73599771
46protein-lipid complex subunit organization (GO:0071825)4.71833826
47regulation of apoptotic cell clearance (GO:2000425)4.70374086
48triglyceride homeostasis (GO:0070328)4.67505449
49acylglycerol homeostasis (GO:0055090)4.67505449
50alpha-amino acid catabolic process (GO:1901606)4.65317546
51phospholipid efflux (GO:0033700)4.62885664
52negative regulation of cholesterol transport (GO:0032375)4.58667156
53negative regulation of sterol transport (GO:0032372)4.58667156
54amino-acid betaine metabolic process (GO:0006577)4.55639481
55lysine metabolic process (GO:0006553)4.53557479
56lysine catabolic process (GO:0006554)4.53557479
57negative regulation of blood coagulation (GO:0030195)4.50752480
58negative regulation of hemostasis (GO:1900047)4.50752480
59imidazole-containing compound metabolic process (GO:0052803)4.47999285
60glycine metabolic process (GO:0006544)4.45933516
61coenzyme catabolic process (GO:0009109)4.43765563
62plasma lipoprotein particle clearance (GO:0034381)4.42498708
63amine catabolic process (GO:0009310)4.42145669
64cellular biogenic amine catabolic process (GO:0042402)4.42145669
65positive regulation of fatty acid biosynthetic process (GO:0045723)4.40549593
66bile acid and bile salt transport (GO:0015721)4.39762595
67indolalkylamine metabolic process (GO:0006586)4.38855771
68cellular ketone body metabolic process (GO:0046950)4.37837425
69regulation of humoral immune response (GO:0002920)4.36284784
70glutamate metabolic process (GO:0006536)4.31763512
71negative regulation of protein activation cascade (GO:2000258)4.28727664
72cholesterol efflux (GO:0033344)4.28304185
73cellular amino acid catabolic process (GO:0009063)4.26635920
74drug metabolic process (GO:0017144)4.23526579
75serine family amino acid metabolic process (GO:0009069)4.19338869
76cellular glucuronidation (GO:0052695)4.17199203
77proline metabolic process (GO:0006560)4.15282289
78ethanol oxidation (GO:0006069)4.12196176
79positive regulation of hemostasis (GO:1900048)4.11287001
80positive regulation of blood coagulation (GO:0030194)4.11287001
81plasma lipoprotein particle assembly (GO:0034377)4.11166872
82benzene-containing compound metabolic process (GO:0042537)4.10879652
83cellular modified amino acid catabolic process (GO:0042219)4.09158435
84fibrinolysis (GO:0042730)4.08923601
85negative regulation of coagulation (GO:0050819)4.07778844
86serine family amino acid biosynthetic process (GO:0009070)4.05349603
87arginine metabolic process (GO:0006525)4.04878567
88dicarboxylic acid biosynthetic process (GO:0043650)4.04001234
89low-density lipoprotein particle remodeling (GO:0034374)4.02627974
90aldehyde catabolic process (GO:0046185)3.99943040
91negative regulation of wound healing (GO:0061045)3.97188140
92positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.95944825
93blood coagulation, intrinsic pathway (GO:0007597)3.93461759
94ethanol metabolic process (GO:0006067)3.90859275
95lipoprotein metabolic process (GO:0042157)3.87910213
96cofactor catabolic process (GO:0051187)3.83453216
97drug catabolic process (GO:0042737)3.83320135
98positive regulation of lipoprotein lipase activity (GO:0051006)3.83295560
99positive regulation of triglyceride lipase activity (GO:0061365)3.83295560
100complement activation, classical pathway (GO:0006958)3.83133578
101phospholipid homeostasis (GO:0055091)3.80039382
102very-low-density lipoprotein particle assembly (GO:0034379)3.79805997
103protein activation cascade (GO:0072376)3.79151766
104ketone body metabolic process (GO:1902224)3.79072684
105complement activation (GO:0006956)3.78163466
106regulation of bile acid biosynthetic process (GO:0070857)3.77421980
107cholesterol homeostasis (GO:0042632)3.77164270
108positive regulation of coagulation (GO:0050820)3.74965954
109regulation of cholesterol homeostasis (GO:2000188)3.74917570
110negative regulation of lipase activity (GO:0060192)3.72957164
111positive regulation of lipid catabolic process (GO:0050996)3.72419669
112oxidative demethylation (GO:0070989)3.71395659
113organic acid catabolic process (GO:0016054)3.70979843
114carboxylic acid catabolic process (GO:0046395)3.70979843
115sterol homeostasis (GO:0055092)3.70753025
116plasma lipoprotein particle organization (GO:0071827)3.70669554
117uronic acid metabolic process (GO:0006063)3.68776013
118glucuronate metabolic process (GO:0019585)3.68776013
119cytolysis (GO:0019835)3.68430259
120protein-lipid complex assembly (GO:0065005)3.68240626
121acetyl-CoA metabolic process (GO:0006084)3.65653807
122sterol transport (GO:0015918)3.63042561
123cholesterol transport (GO:0030301)3.63042561
124opsonization (GO:0008228)3.58638564
125NAD biosynthetic process (GO:0009435)3.58298085
126short-chain fatty acid metabolic process (GO:0046459)3.57723980
127intestinal absorption (GO:0050892)3.57195642
128regulation of cholesterol biosynthetic process (GO:0045540)3.51489658
129acute inflammatory response (GO:0002526)3.50582323
130phenylpropanoid metabolic process (GO:0009698)3.46190596
131regulation of fatty acid biosynthetic process (GO:0042304)3.43306016
132regulation of lipoprotein particle clearance (GO:0010984)3.41994787
133negative regulation of lipid transport (GO:0032369)3.37673509
134negative regulation of complement activation (GO:0045916)3.37029581
135peptidyl-glutamic acid modification (GO:0018200)3.35103323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.42483928
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.25857666
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.05187602
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.53579862
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.34036245
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10395292
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80466274
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.07845033
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.96446414
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05149796
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0738161
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98574466
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94637388
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67180864
15P68_20966046_ChIP-Seq_HELA_Human1.67091792
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.60495140
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54444319
18CLOCK_20551151_ChIP-Seq_293T_Human1.54440535
19GATA1_22025678_ChIP-Seq_K562_Human1.51275048
20HTT_18923047_ChIP-ChIP_STHdh_Human1.49376021
21SMC4_20622854_ChIP-Seq_HELA_Human1.47959346
22RACK7_27058665_Chip-Seq_MCF-7_Human1.47867168
23VDR_21846776_ChIP-Seq_THP-1_Human1.47707812
24* ERG_21242973_ChIP-ChIP_JURKAT_Human1.46906811
25CTCF_27219007_Chip-Seq_Bcells_Human1.42502288
26SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41536486
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39975181
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37479537
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31798532
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31783215
31E2F1_20622854_ChIP-Seq_HELA_Human1.30975570
32* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30009675
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.27593908
34RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22244591
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22156609
36* TET1_21451524_ChIP-Seq_MESCs_Mouse1.21281645
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.21087285
38BCL6_27268052_Chip-Seq_Bcells_Human1.19778396
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18112452
40PHF8_20622854_ChIP-Seq_HELA_Human1.16592593
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12195686
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10704905
43CREB1_26743006_Chip-Seq_LNCaP_Human1.06837817
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.06145298
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05746557
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04890391
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.04692968
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01337112
49* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98674066
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98275226
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98031215
52JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97562747
53STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96578904
54KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96416755
55SA1_27219007_Chip-Seq_Bcells_Human0.95790675
56SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93843096
57TCF7_22412390_ChIP-Seq_EML_Mouse0.93777638
58IRF8_22096565_ChIP-ChIP_GC-B_Human0.92949256
59SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92131254
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90713337
61TP53_22127205_ChIP-Seq_IMR90_Human0.90075823
62CTCF_20526341_ChIP-Seq_ESCs_Human0.89826482
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89117314
64RAC3_21632823_ChIP-Seq_H3396_Human0.88301976
65* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87031136
66RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86317621
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86239891
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85991945
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85445640
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83386366
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83325357
72KDM2B_26808549_Chip-Seq_K562_Human0.82569572
73HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81405299
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80421066
75ZNF263_19887448_ChIP-Seq_K562_Human0.80306180
76GATA4_25053715_ChIP-Seq_YYC3_Human0.79695269
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79407277
78YY1_22570637_ChIP-Seq_MALME-3M_Human0.78859388
79ETS1_21867929_ChIP-Seq_TH2_Mouse0.78439522
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78408521
81CTCF_21964334_Chip-Seq_Bcells_Human0.78306961
82TRIM28_21343339_ChIP-Seq_HEK293_Human0.78301240
83SOX2_21211035_ChIP-Seq_LN229_Human0.77504344
84RARA_24833708_ChIP-Seq_LIVER_Mouse0.76966593
85RUNX1_27514584_Chip-Seq_MCF-7_Human0.76399513
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76107403
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75770245
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75460197
89CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75425989
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73561441
91ERA_21632823_ChIP-Seq_H3396_Human0.73262414
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72696314
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72174475
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72070679
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70611954
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67632846
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66336749
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.65229363
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65000285
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64952848
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.64425134
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62159252
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61326076
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60214918
105LXR_22292898_ChIP-Seq_THP-1_Human0.59871753
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58084943
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58084943
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57837567
109CEBPB_22108803_ChIP-Seq_LS180_Human0.57271784
110EGR1_19032775_ChIP-ChIP_M12_Human0.53537680
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52012015
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.52010154
113MYC_19915707_ChIP-ChIP_AK7_Human0.51475666
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50961634
115AR_20517297_ChIP-Seq_VCAP_Human0.50622060
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50160357
117GATA1_19941826_ChIP-Seq_K562_Human0.50126919
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49304886
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.49172415
120* GATA1_19941827_ChIP-Seq_MEL_Mouse0.47090539
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.46847906
122P53_21459846_ChIP-Seq_SAOS-2_Human0.45767227
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.45386140
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44434005
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44323715
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.44202296
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44199049
128GATA2_19941826_ChIP-Seq_K562_Human0.43877469
129STAT1_17558387_ChIP-Seq_HELA_Human0.43607699
130GATA6_25053715_ChIP-Seq_YYC3_Human0.43170374
131CBP_21632823_ChIP-Seq_H3396_Human0.43099591
132TAF2_19829295_ChIP-Seq_ESCs_Human0.42192555
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41800178
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.41610108
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.40953728
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40883800
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.39985342
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.38335807
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37718633
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37325516
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36060995
142BCOR_27268052_Chip-Seq_Bcells_Human0.34963046
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.33997784
144SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33424862
145* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33058208
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.33031050
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.32991938
148TAF15_26573619_Chip-Seq_HEK293_Human0.32925826
149* SPI1_26923725_Chip-Seq_HPCs_Mouse0.32700608
150BCAT_22108803_ChIP-Seq_LS180_Human0.32387961
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.32247463
152OCT4_20526341_ChIP-Seq_ESCs_Human0.31953696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.26355762
2MP0005360_urolithiasis7.49312777
3MP0005085_abnormal_gallbladder_physiolo6.45119113
4MP0005365_abnormal_bile_salt6.13659403
5MP0008875_abnormal_xenobiotic_pharmacok5.07266243
6MP0003806_abnormal_nucleotide_metabolis4.28627948
7MP0003252_abnormal_bile_duct3.92336168
8MP0010329_abnormal_lipoprotein_level3.62263168
9MP0009840_abnormal_foam_cell3.32624548
10MP0005083_abnormal_biliary_tract3.18772411
11MP0003195_calcinosis2.85930893
12MP0005332_abnormal_amino_acid2.74414942
13MP0001666_abnormal_nutrient_absorption2.60754969
14MP0003191_abnormal_cellular_cholesterol2.41082130
15MP0000609_abnormal_liver_physiology2.20252052
16MP0004019_abnormal_vitamin_homeostasis2.10914320
17MP0002118_abnormal_lipid_homeostasis2.10569390
18MP0002138_abnormal_hepatobiliary_system1.95708277
19MP0003868_abnormal_feces_composition1.89057465
20MP0005319_abnormal_enzyme/_coenzyme1.82954520
21MP0005058_abnormal_lysosome_morphology1.68107049
22MP0000566_synostosis1.67486473
23MP0003172_abnormal_lysosome_physiology1.65678887
24MP0001764_abnormal_homeostasis1.64441644
25MP0005584_abnormal_enzyme/coenzyme_acti1.55637062
26MP0009697_abnormal_copulation1.55466659
27MP0003011_delayed_dark_adaptation1.43235646
28MP0005451_abnormal_body_composition1.42609835
29MP0003656_abnormal_erythrocyte_physiolo1.38578438
30MP0005409_darkened_coat_color1.37933083
31MP0003122_maternal_imprinting1.33826874
32MP0003186_abnormal_redox_activity1.24752640
33MP0002089_abnormal_postnatal_growth/wei1.23606102
34MP0009643_abnormal_urine_homeostasis1.21109903
35MP0003705_abnormal_hypodermis_morpholog1.21090387
36* MP0000598_abnormal_liver_morphology1.18755038
37MP0005647_abnormal_sex_gland1.14657783
38MP0001986_abnormal_taste_sensitivity1.12913331
39MP0002254_reproductive_system_inflammat1.09977084
40MP0000604_amyloidosis1.09663317
41MP0009764_decreased_sensitivity_to1.07318717
42MP0003879_abnormal_hair_cell1.06466858
43MP0009763_increased_sensitivity_to1.05122725
44MP0001915_intracranial_hemorrhage1.02479693
45MP0010368_abnormal_lymphatic_system0.99125404
46MP0005636_abnormal_mineral_homeostasis0.92127589
47MP0008469_abnormal_protein_level0.91370041
48MP0009642_abnormal_blood_homeostasis0.87579333
49MP0002249_abnormal_larynx_morphology0.87577807
50MP0005408_hypopigmentation0.81537748
51MP0006036_abnormal_mitochondrial_physio0.79822164
52MP0009765_abnormal_xenobiotic_induced0.79191763
53MP0005376_homeostasis/metabolism_phenot0.79186783
54MP0002078_abnormal_glucose_homeostasis0.77097529
55MP0005084_abnormal_gallbladder_morpholo0.74680196
56MP0005670_abnormal_white_adipose0.74645407
57MP0005220_abnormal_exocrine_pancreas0.74330036
58MP0002971_abnormal_brown_adipose0.73351290
59MP0002876_abnormal_thyroid_physiology0.72304035
60MP0005377_hearing/vestibular/ear_phenot0.70942082
61MP0003878_abnormal_ear_physiology0.70942082
62MP0005334_abnormal_fat_pad0.69365605
63MP0001661_extended_life_span0.66751829
64MP0003690_abnormal_glial_cell0.65088364
65MP0004130_abnormal_muscle_cell0.64971705
66MP0009053_abnormal_anal_canal0.64574452
67MP0005535_abnormal_body_temperature0.64500248
68MP0005266_abnormal_metabolism0.64151782
69MP0000003_abnormal_adipose_tissue0.63989119
70MP0003329_amyloid_beta_deposits0.60627792
71MP0005464_abnormal_platelet_physiology0.60544492
72MP0000639_abnormal_adrenal_gland0.59942209
73MP0003136_yellow_coat_color0.57898315
74MP0006035_abnormal_mitochondrial_morpho0.56961923
75MP0001756_abnormal_urination0.56546757
76MP0002282_abnormal_trachea_morphology0.56060774
77MP0005076_abnormal_cell_differentiation0.55812965
78MP0000678_abnormal_parathyroid_gland0.55615325
79MP0005448_abnormal_energy_balance0.54955933
80MP0005023_abnormal_wound_healing0.53859529
81MP0005257_abnormal_intraocular_pressure0.52333446
82MP0003436_decreased_susceptibility_to0.51129215
83MP0005395_other_phenotype0.50318956
84MP0002909_abnormal_adrenal_gland0.50293056
85MP0003718_maternal_effect0.49772435
86MP0005167_abnormal_blood-brain_barrier0.49102585
87MP0002928_abnormal_bile_duct0.47100357
88MP0003724_increased_susceptibility_to0.46514648
89MP0008873_increased_physiological_sensi0.46148197
90MP0004272_abnormal_basement_membrane0.45319227
91MP0003638_abnormal_response/metabolism_0.45188322
92MP0008874_decreased_physiological_sensi0.45014879
93MP0003123_paternal_imprinting0.44966838
94MP0002136_abnormal_kidney_physiology0.44848574
95MP0002822_catalepsy0.44506505
96MP0004381_abnormal_hair_follicle0.43376221
97MP0003075_altered_response_to0.40624489
98MP0003632_abnormal_nervous_system0.40330708
99MP0004782_abnormal_surfactant_physiolog0.40217072
100MP0003183_abnormal_peptide_metabolism0.40129649
101MP0004264_abnormal_extraembryonic_tissu0.40048164
102MP0000579_abnormal_nail_morphology0.39840497
103MP0002933_joint_inflammation0.39807830
104MP0005375_adipose_tissue_phenotype0.39695154
105MP0005166_decreased_susceptibility_to0.39654529
106MP0003953_abnormal_hormone_level0.39592961
107MP0005248_abnormal_Harderian_gland0.38186809
108MP0009672_abnormal_birth_weight0.37259198
109MP0004043_abnormal_pH_regulation0.37223538
110MP0005330_cardiomyopathy0.36797628
111MP0008872_abnormal_physiological_respon0.36361607
112MP0006082_CNS_inflammation0.36104585
113MP0002837_dystrophic_cardiac_calcinosis0.35407152
114MP0002796_impaired_skin_barrier0.35249176
115MP0005666_abnormal_adipose_tissue0.35132354
116MP0001243_abnormal_dermal_layer0.35013929
117MP0003115_abnormal_respiratory_system0.34813602
118MP0009780_abnormal_chondrocyte_physiolo0.33537541
119MP0009384_cardiac_valve_regurgitation0.32699876
120MP0002970_abnormal_white_adipose0.32586071
121MP0000249_abnormal_blood_vessel0.32535176
122MP0009115_abnormal_fat_cell0.32072902
123MP0000858_altered_metastatic_potential0.31946339
124MP0001853_heart_inflammation0.31325872
125MP0004883_abnormal_blood_vessel0.31202417
126MP0001845_abnormal_inflammatory_respons0.31104330
127MP0002168_other_aberrant_phenotype0.30177779
128MP0002132_abnormal_respiratory_system0.30087856
129MP0000013_abnormal_adipose_tissue0.29839973
130MP0001881_abnormal_mammary_gland0.28972979
131MP0000230_abnormal_systemic_arterial0.28846801
132MP0002060_abnormal_skin_morphology0.25726986
133MP0003453_abnormal_keratinocyte_physiol0.25144061
134MP0005164_abnormal_response_to0.25096316

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.49283200
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42047976
3Intrahepatic cholestasis (HP:0001406)7.30134345
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.71965663
5Prolonged partial thromboplastin time (HP:0003645)6.67592353
6Hypobetalipoproteinemia (HP:0003563)6.42205392
7Xanthomatosis (HP:0000991)6.32134059
8Hyperlipoproteinemia (HP:0010980)5.58846041
9Complement deficiency (HP:0004431)5.44331853
10Joint hemorrhage (HP:0005261)4.92754328
11Hypolipoproteinemia (HP:0010981)4.82164325
12Abnormality of the common coagulation pathway (HP:0010990)4.60498572
13Epidermoid cyst (HP:0200040)4.56597008
14Hyperammonemia (HP:0001987)4.54868493
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40495215
16Hyperglycinemia (HP:0002154)4.36911135
17Abnormality of methionine metabolism (HP:0010901)4.27595880
18Hypoalphalipoproteinemia (HP:0003233)4.24501526
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.24151172
20Ketosis (HP:0001946)4.19462205
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10256735
22Fat malabsorption (HP:0002630)4.09897828
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08515433
24Abnormality of complement system (HP:0005339)3.98958835
25Abnormality of glycine metabolism (HP:0010895)3.85183518
26Abnormality of serine family amino acid metabolism (HP:0010894)3.85183518
27Abnormality of pyrimidine metabolism (HP:0004353)3.85073561
28Hyperglycinuria (HP:0003108)3.83461110
29Abnormality of the intrinsic pathway (HP:0010989)3.81711861
30Hypoglycemic coma (HP:0001325)3.79663703
31Conjugated hyperbilirubinemia (HP:0002908)3.70342302
32Hypercholesterolemia (HP:0003124)3.64530911
33Hyperbilirubinemia (HP:0002904)3.37213270
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29987490
35Spontaneous abortion (HP:0005268)3.24207235
36Abnormality of fatty-acid metabolism (HP:0004359)3.24138030
37Hypochromic microcytic anemia (HP:0004840)3.14672666
38Myocardial infarction (HP:0001658)3.08269420
39Steatorrhea (HP:0002570)3.07069985
40Abnormality of nucleobase metabolism (HP:0010932)3.03926548
41Delayed CNS myelination (HP:0002188)3.03918742
42Hepatocellular carcinoma (HP:0001402)3.02019801
43Abnormality of serum amino acid levels (HP:0003112)3.01632481
44Ketoacidosis (HP:0001993)2.91529875
45Purpura (HP:0000979)2.85559371
46Skin nodule (HP:0200036)2.79411360
47Systemic lupus erythematosus (HP:0002725)2.76983940
48Metabolic acidosis (HP:0001942)2.71302726
49Acanthocytosis (HP:0001927)2.69246633
50Abnormality of purine metabolism (HP:0004352)2.63353041
51Vascular calcification (HP:0004934)2.60266280
52Abnormal gallbladder morphology (HP:0012437)2.53329748
53Lethargy (HP:0001254)2.52144951
54Dicarboxylic aciduria (HP:0003215)2.49612654
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49612654
56Mitral stenosis (HP:0001718)2.49185322
57Glomerulonephritis (HP:0000099)2.49123183
58Vaginal fistula (HP:0004320)2.49121806
59Cholelithiasis (HP:0001081)2.48180563
60Spastic diplegia (HP:0001264)2.47040573
61Hypoglycemic seizures (HP:0002173)2.45479808
62Recurrent gram-negative bacterial infections (HP:0005420)2.43289039
63Gout (HP:0001997)2.42151201
64Amyloidosis (HP:0011034)2.40748446
65Cholecystitis (HP:0001082)2.39027374
66Abnormal gallbladder physiology (HP:0012438)2.39027374
67Gingival bleeding (HP:0000225)2.37498856
68Neonatal onset (HP:0003623)2.34258774
69Cerebral edema (HP:0002181)2.33496488
70Irritability (HP:0000737)2.32189777
71Cardiovascular calcification (HP:0011915)2.30360398
72Malnutrition (HP:0004395)2.29278727
73Menorrhagia (HP:0000132)2.23653718
74Esophageal varix (HP:0002040)2.20945798
75Poikilocytosis (HP:0004447)2.19501740
76Thrombophlebitis (HP:0004418)2.18471215
77Osteomalacia (HP:0002749)2.12997786
78Brushfield spots (HP:0001088)2.11652381
79Pancreatitis (HP:0001733)2.11614375
80Sensorimotor neuropathy (HP:0007141)2.11179443
81Hemorrhage of the eye (HP:0011885)2.10656775
82Enlarged kidneys (HP:0000105)2.10484780
83Late onset (HP:0003584)2.10374930
84Widely patent fontanelles and sutures (HP:0004492)2.05717934
85Opisthotonus (HP:0002179)2.04684753
86Abnormality of the gallbladder (HP:0005264)2.04239298
87Vomiting (HP:0002013)2.02621094
88Abnormality of iron homeostasis (HP:0011031)1.99548117
89Hyperinsulinemic hypoglycemia (HP:0000825)1.99269200
90Ulnar bowing (HP:0003031)1.95685056
91Abnormality of transition element cation homeostasis (HP:0011030)1.95052325
92Generalized aminoaciduria (HP:0002909)1.94104337
93Rickets (HP:0002748)1.93787192
94Mucopolysacchariduria (HP:0008155)1.92478288
95Urinary glycosaminoglycan excretion (HP:0003541)1.92478288
96Abnormality of the Achilles tendon (HP:0005109)1.89362356
97Hypophosphatemic rickets (HP:0004912)1.87776891
98Abnormality of carpal bone ossification (HP:0006257)1.86337643
99Abnormal cartilage morphology (HP:0002763)1.84722251
100Epistaxis (HP:0000421)1.84466853
101Renal cortical cysts (HP:0000803)1.81858001
102Reticulocytosis (HP:0001923)1.81677099
103Elevated alkaline phosphatase (HP:0003155)1.81593291
104Elevated hepatic transaminases (HP:0002910)1.81027478
105Hydroxyprolinuria (HP:0003080)1.80820655
106Abnormality of proline metabolism (HP:0010907)1.80820655
107Abnormal enzyme/coenzyme activity (HP:0012379)1.79473862
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79416632
109Abnormality of polysaccharide metabolism (HP:0011012)1.79416632
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79416632
111Status epilepticus (HP:0002133)1.78714867
112Abnormality of alkaline phosphatase activity (HP:0004379)1.78443858
113Nephritis (HP:0000123)1.77390660
114Facial shape deformation (HP:0011334)1.76658270
115Potter facies (HP:0002009)1.76658270
116Alkalosis (HP:0001948)1.75348437
117Abnormal tarsal ossification (HP:0008369)1.74542301
118Thin bony cortex (HP:0002753)1.74441335
119Bifid scrotum (HP:0000048)1.73235219
120Pulmonary embolism (HP:0002204)1.71564498
121Arthropathy (HP:0003040)1.71216926
122Increased serum ferritin (HP:0003281)1.66579200
123Hypophosphatemia (HP:0002148)1.65899190
124Abnormal urine phosphate concentration (HP:0012599)1.65563790
125Reduced antithrombin III activity (HP:0001976)1.65108987
126Abnormal delivery (HP:0001787)1.61137321
127Hypertriglyceridemia (HP:0002155)1.56750427
128Mesangial abnormality (HP:0001966)1.54218288
129Asymmetry of the thorax (HP:0001555)1.51469985
130Retinal atrophy (HP:0001105)1.48649762
131Joint swelling (HP:0001386)1.48209160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.88666752
2FGFR44.72576239
3ERN14.62718295
4SIK14.61803194
5WNK43.35038240
6TAOK33.28744922
7ERBB42.97836112
8INSRR2.85611415
9PKN22.34056367
10MAP2K42.30657138
11MST1R2.05106037
12CDK122.00109878
13MAPK111.96525368
14FLT31.93179940
15TRIB31.88317796
16TYK21.87100055
17PIK3CG1.77175782
18PDGFRA1.72291953
19SIK21.63814608
20TYRO31.62622559
21LATS11.61119659
22PTK61.54309164
23DAPK21.47785338
24ABL21.41658830
25WNK11.37874195
26NEK91.34225267
27EEF2K1.33700000
28KDR1.32196077
29JAK21.31778401
30FGFR21.28172044
31GRK61.24079589
32PINK11.22676762
33MAP3K71.22084360
34FRK1.21712828
35PIK3CA1.19475289
36EPHA21.16212048
37NTRK31.11630493
38MAP2K31.11485401
39TBK11.11164028
40JAK11.09995646
41MAP3K101.09795732
42PRKAA21.09542434
43SMG11.07794636
44ERBB21.07737590
45DDR21.06372148
46AKT31.03564046
47MUSK1.02144396
48MAP3K140.99727037
49FGFR10.98590566
50MAPK40.98261471
51EPHB10.90187721
52PDK20.89547833
53MAPK150.87301208
54PRKCZ0.87221473
55MAP3K110.87197067
56CDK60.83221650
57MAP3K30.83197676
58CDC42BPA0.81933180
59MET0.79938660
60MAPK120.79196317
61PRPF4B0.76996499
62DYRK1B0.76433500
63MARK20.75978803
64EPHA30.75970915
65CSK0.75839491
66PRKACG0.75105193
67MAP3K20.73299801
68ZAP700.73263151
69IRAK30.71425160
70STK38L0.69800360
71CAMK1D0.68640491
72BLK0.68267925
73MAP2K60.66556408
74GSK3A0.66168313
75SGK30.65295851
76TIE10.64693437
77FGFR30.63964046
78CAMK2G0.63819809
79PRKAA10.63710457
80TGFBR20.61926849
81CSF1R0.61607464
82IKBKE0.60759313
83RIPK10.57491160
84PTK20.56605826
85MAPK70.55500001
86SGK10.54700887
87PDPK10.52428484
88PRKCQ0.51300640
89GRK10.46950028
90PKN10.45612269
91SGK20.45538297
92CDK40.44642062
93PDGFRB0.44450046
94CSNK1G10.42536772
95RPS6KB10.42280062
96TAOK20.42171554
97RPS6KC10.42144270
98RPS6KL10.42144270
99MAP3K50.41973045
100MAPKAPK30.41555977
101RPS6KA20.41334540
102PRKD20.40982938
103MAP3K130.40802506
104RET0.40672401
105IGF1R0.40080706
106MTOR0.39741425
107CDK70.39735019
108KSR20.39521553
109NEK20.39158847
110CSNK1D0.39048751
111MAP2K10.39001340
112ICK0.35186391
113EGFR0.34524563
114SRC0.34476821
115PRKCG0.34377093
116TNK20.33761390
117RPS6KA60.32968275
118CAMK1G0.32930645
119PDK10.32030685
120MAP3K60.31823496
121CAMK40.31683653
122EPHA40.31028505
123MAPK80.30307539
124FGR0.29789605
125MAP4K10.29498126
126SGK4940.28339802
127SGK2230.28339802
128NTRK10.27911386
129RPS6KA30.27787227
130MELK0.27318187
131MAP3K10.27166816
132BMX0.26255642
133PBK0.25762668
134ABL10.22919031
135PRKCA0.22886828
136CSNK1G20.21790572
137CSNK1G30.20416509
138ITK0.20024867
139MAPK30.19169804
140IRAK10.18780302
141MAP2K20.18620211
142LATS20.17168577

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55730455
2Nitrogen metabolism_Homo sapiens_hsa009103.64130501
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40772460
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31492624
5Arginine biosynthesis_Homo sapiens_hsa002203.11083586
6Complement and coagulation cascades_Homo sapiens_hsa046102.85911974
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69147703
8Tryptophan metabolism_Homo sapiens_hsa003802.67801516
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62639631
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57132780
11Fatty acid degradation_Homo sapiens_hsa000712.46594188
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34104087
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22580024
14Butanoate metabolism_Homo sapiens_hsa006502.11738904
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11106632
16Peroxisome_Homo sapiens_hsa041462.06291260
17Chemical carcinogenesis_Homo sapiens_hsa052041.93940891
18Histidine metabolism_Homo sapiens_hsa003401.92955515
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90549592
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90037584
21Propanoate metabolism_Homo sapiens_hsa006401.87357180
22PPAR signaling pathway_Homo sapiens_hsa033201.85805923
23Staphylococcus aureus infection_Homo sapiens_hsa051501.83367905
24Fatty acid metabolism_Homo sapiens_hsa012121.78089022
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76589792
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75443710
27beta-Alanine metabolism_Homo sapiens_hsa004101.69919066
28Caffeine metabolism_Homo sapiens_hsa002321.68598119
29Retinol metabolism_Homo sapiens_hsa008301.68571209
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65832199
31Selenocompound metabolism_Homo sapiens_hsa004501.62101199
32Phenylalanine metabolism_Homo sapiens_hsa003601.56262548
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54492938
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51110502
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49480037
36Bile secretion_Homo sapiens_hsa049761.48993796
37Tyrosine metabolism_Homo sapiens_hsa003501.45793156
38Pyruvate metabolism_Homo sapiens_hsa006201.33218016
39Other glycan degradation_Homo sapiens_hsa005111.33027713
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32711799
41Fatty acid elongation_Homo sapiens_hsa000621.30501220
42Sulfur metabolism_Homo sapiens_hsa009201.29706058
43Starch and sucrose metabolism_Homo sapiens_hsa005001.26899539
44ABC transporters_Homo sapiens_hsa020101.23479339
45Folate biosynthesis_Homo sapiens_hsa007901.22460915
46Biosynthesis of amino acids_Homo sapiens_hsa012301.21534300
47Steroid biosynthesis_Homo sapiens_hsa001001.21019574
48Fat digestion and absorption_Homo sapiens_hsa049751.16856845
49Carbon metabolism_Homo sapiens_hsa012001.11407430
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03208934
51Vitamin B6 metabolism_Homo sapiens_hsa007501.02529180
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.01767838
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01144216
54Sulfur relay system_Homo sapiens_hsa041221.00336284
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.99631660
56Arginine and proline metabolism_Homo sapiens_hsa003300.95507836
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87661804
58Vitamin digestion and absorption_Homo sapiens_hsa049770.84901915
59Lysine degradation_Homo sapiens_hsa003100.83888697
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83222452
61One carbon pool by folate_Homo sapiens_hsa006700.82575854
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70233198
63Glycerolipid metabolism_Homo sapiens_hsa005610.66334352
64Glutathione metabolism_Homo sapiens_hsa004800.63474893
65Pentose phosphate pathway_Homo sapiens_hsa000300.57705068
66Fatty acid biosynthesis_Homo sapiens_hsa000610.52521966
67Pertussis_Homo sapiens_hsa051330.46103113
68Metabolic pathways_Homo sapiens_hsa011000.45231286
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43860192
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41300310
71Sphingolipid metabolism_Homo sapiens_hsa006000.37714408
72Prion diseases_Homo sapiens_hsa050200.36857102
73Mineral absorption_Homo sapiens_hsa049780.30955763
74Galactose metabolism_Homo sapiens_hsa000520.27195213
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26433411
76Insulin resistance_Homo sapiens_hsa049310.24491034
77Fructose and mannose metabolism_Homo sapiens_hsa000510.23914719
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.23028293
79Linoleic acid metabolism_Homo sapiens_hsa005910.20447810
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17175412
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.16213331
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15591599
83N-Glycan biosynthesis_Homo sapiens_hsa005100.14674952
84Glucagon signaling pathway_Homo sapiens_hsa049220.10201751
85AMPK signaling pathway_Homo sapiens_hsa041520.02070009
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2401763
87Amoebiasis_Homo sapiens_hsa05146-0.2386141
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2361145
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2276628
90Bladder cancer_Homo sapiens_hsa05219-0.2133624
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2085396
92Renin-angiotensin system_Homo sapiens_hsa04614-0.2018592
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1823297
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1756297
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1735303
96Regulation of autophagy_Homo sapiens_hsa04140-0.1509574
97Hepatitis C_Homo sapiens_hsa05160-0.1481448
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1451541
99African trypanosomiasis_Homo sapiens_hsa05143-0.1422793
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1415332
101Insulin signaling pathway_Homo sapiens_hsa04910-0.0958621
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0911071
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0852892
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.0794551
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0752998
106ECM-receptor interaction_Homo sapiens_hsa04512-0.0727067
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0690687
108Lysosome_Homo sapiens_hsa04142-0.0600959
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0585436
110Circadian rhythm_Homo sapiens_hsa04710-0.0273933

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