ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cholesterol transport (GO:0032375)	6.61182952
2	negative regulation of sterol transport (GO:0032372)	6.61182952
3	regulation of protein activation cascade (GO:2000257)	6.44177991
4	regulation of fibrinolysis (GO:0051917)	6.36296151
5	negative regulation of fibrinolysis (GO:0051918)	6.28419926
6	regulation of complement activation (GO:0030449)	6.23752062
7	peptidyl-glutamic acid carboxylation (GO:0017187)	6.12693267
8	protein carboxylation (GO:0018214)	6.12693267
9	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.08305625
10	epoxygenase P450 pathway (GO:0019373)	5.95269186
11	complement activation, alternative pathway (GO:0006957)	5.93795105
12	response to mercury ion (GO:0046689)	5.91977917
13	high-density lipoprotein particle remodeling (GO:0034375)	5.83399471
14	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.68809062
15	L-phenylalanine catabolic process (GO:0006559)	5.68809062
16	protein-lipid complex remodeling (GO:0034368)	5.63620870
17	macromolecular complex remodeling (GO:0034367)	5.63620870
18	plasma lipoprotein particle remodeling (GO:0034369)	5.63620870
19	regulation of cholesterol esterification (GO:0010872)	5.52898062
20	very-low-density lipoprotein particle assembly (GO:0034379)	5.38981951
21	plasma lipoprotein particle assembly (GO:0034377)	5.36636717
22	cholesterol efflux (GO:0033344)	5.33528819
23	phospholipid efflux (GO:0033700)	5.32994942
24	reverse cholesterol transport (GO:0043691)	5.29052792
25	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.27721799
26	L-phenylalanine metabolic process (GO:0006558)	5.27721799
27	drug catabolic process (GO:0042737)	5.10295388
28	glyoxylate metabolic process (GO:0046487)	5.07150300
29	intestinal cholesterol absorption (GO:0030299)	5.05088120
30	regulation of plasminogen activation (GO:0010755)	5.01992275
31	blood coagulation, intrinsic pathway (GO:0007597)	4.99143555
32	ethanol oxidation (GO:0006069)	4.84545970
33	exogenous drug catabolic process (GO:0042738)	4.81840602
34	protein-lipid complex assembly (GO:0065005)	4.76424249
35	omega-hydroxylase P450 pathway (GO:0097267)	4.75950051
36	plasma lipoprotein particle organization (GO:0071827)	4.70677634
37	regulation of triglyceride catabolic process (GO:0010896)	4.69805151
38	fibrinolysis (GO:0042730)	4.44554748
39	protein-lipid complex subunit organization (GO:0071825)	4.41831989
40	triglyceride homeostasis (GO:0070328)	4.41298529
41	acylglycerol homeostasis (GO:0055090)	4.41298529
42	drug metabolic process (GO:0017144)	4.36690337
43	low-density lipoprotein particle remodeling (GO:0034374)	4.28236249
44	negative regulation of protein activation cascade (GO:2000258)	4.25716057
45	aromatic amino acid family catabolic process (GO:0009074)	4.21868228
46	cellular glucuronidation (GO:0052695)	4.18797198
47	plasma lipoprotein particle clearance (GO:0034381)	4.15445327
48	negative regulation of lipase activity (GO:0060192)	4.15008970
49	urate metabolic process (GO:0046415)	4.14553136
50	urea metabolic process (GO:0019627)	4.12562556
51	positive regulation of triglyceride lipase activity (GO:0061365)	4.12213264
52	positive regulation of lipoprotein lipase activity (GO:0051006)	4.12213264
53	protein activation cascade (GO:0072376)	4.11320203
54	negative regulation of hemostasis (GO:1900047)	4.02185331
55	negative regulation of blood coagulation (GO:0030195)	4.02185331
56	intestinal absorption (GO:0050892)	4.02158345
57	lipoprotein metabolic process (GO:0042157)	4.01703926
58	acute-phase response (GO:0006953)	3.98145536
59	glutamate metabolic process (GO:0006536)	3.97519436
60	serine family amino acid catabolic process (GO:0009071)	3.97326277
61	glucuronate metabolic process (GO:0019585)	3.96442189
62	uronic acid metabolic process (GO:0006063)	3.96442189
63	flavonoid metabolic process (GO:0009812)	3.96422520
64	amino-acid betaine metabolic process (GO:0006577)	3.90553243
65	complement activation, classical pathway (GO:0006958)	3.90172406
66	ethanol metabolic process (GO:0006067)	3.87636954
67	excretion (GO:0007588)	3.85672490
68	regulation of apoptotic cell clearance (GO:2000425)	3.82367623
69	regulation of bile acid biosynthetic process (GO:0070857)	3.81085371
70	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.79898750
71	urea cycle (GO:0000050)	3.76371300
72	bile acid metabolic process (GO:0008206)	3.75918765
73	negative regulation of coagulation (GO:0050819)	3.73318601
74	cholesterol homeostasis (GO:0042632)	3.72832082
75	imidazole-containing compound metabolic process (GO:0052803)	3.69628624
76	regulation of humoral immune response (GO:0002920)	3.67957313
77	sterol homeostasis (GO:0055092)	3.67271620
78	polyol transport (GO:0015791)	3.66667266
79	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.65361717
80	nitrogen cycle metabolic process (GO:0071941)	3.64563829
81	complement activation (GO:0006956)	3.61569480
82	negative regulation of wound healing (GO:0061045)	3.57362371
83	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.56465305
84	negative regulation of complement activation (GO:0045916)	3.52284082
85	bile acid biosynthetic process (GO:0006699)	3.51384932
86	drug transmembrane transport (GO:0006855)	3.50984848
87	proline metabolic process (GO:0006560)	3.43913173
88	phosphate ion homeostasis (GO:0055062)	3.40702943
89	trivalent inorganic anion homeostasis (GO:0072506)	3.40702943
90	sterol transport (GO:0015918)	3.40547691
91	cholesterol transport (GO:0030301)	3.40547691
92	phenylpropanoid metabolic process (GO:0009698)	3.40404777
93	bile acid and bile salt transport (GO:0015721)	3.39800197
94	S-adenosylmethionine metabolic process (GO:0046500)	3.39513250
95	diacylglycerol metabolic process (GO:0046339)	3.39281906
96	negative regulation of lipid transport (GO:0032369)	3.38638812
97	glycine metabolic process (GO:0006544)	3.31997192
98	positive regulation of lipid catabolic process (GO:0050996)	3.31972025
99	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.24260383
100	aminoglycoside antibiotic metabolic process (GO:0030647)	3.22458178

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	8.79343757
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.35800795
3	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.57656683
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.56980244
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.53527501
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.59869090
7	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.21090075
8	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.89700503
9	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.74581832
10	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.67124934
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.50062908
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.41480974
13	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.40220968
14	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.23199708
15	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.01251363
16	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.89310140
17	GATA4_25053715_ChIP-Seq_YYC3_Human	1.86312001
18	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.70905538
19	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.59967569
20	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.52560567
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.50393107
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50377765
23	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.48005328
24	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.41188190
25	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.39366872
26	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.38994994
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.38444254
28	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.30874425
29	GATA6_25053715_ChIP-Seq_YYC3_Human	1.28785787
30	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.26632009
31	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.24144657
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.20809783
33	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.14801291
34	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.10133317
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.09750050
36	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.09136036
37	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.08554513
38	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.07874190
39	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.07435799
40	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.05718162
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04340084
42	SOX2_20726797_ChIP-Seq_SW620_Human	1.02039980
43	CDX2_22108803_ChIP-Seq_LS180_Human	1.00508912
44	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.95971569
45	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.95408102
46	RXR_22108803_ChIP-Seq_LS180_Human	0.93798602
47	DROSHA_22980978_ChIP-Seq_HELA_Human	0.92998825
48	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.91468362
49	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.90830199
50	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.88590593
51	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.88330104
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.87631043
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.87440106
54	CTCF_27219007_Chip-Seq_Bcells_Human	0.85501976
55	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.85465471
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.85102389
57	CEBPB_22108803_ChIP-Seq_LS180_Human	0.84577931
58	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.83564197
59	TCF4_22108803_ChIP-Seq_LS180_Human	0.82277933
60	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.80046590
61	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.79618817
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79356907
63	CLOCK_20551151_ChIP-Seq_293T_Human	0.78978001
64	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.78358852
65	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.78018745
66	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.77132967
67	LXR_22292898_ChIP-Seq_THP-1_Human	0.76740691
68	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.76727759
69	OCT4_20526341_ChIP-Seq_ESCs_Human	0.76131769
70	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.73919765
71	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.73618982
72	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.73484131
73	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.73052867
74	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.72892330
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.72545321
76	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.72328545
77	RAC3_21632823_ChIP-Seq_H3396_Human	0.71818100
78	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.71765279
79	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.69927326
80	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.69924175
81	HTT_18923047_ChIP-ChIP_STHdh_Human	0.68470945
82	MYC_19829295_ChIP-Seq_ESCs_Human	0.68258112
83	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.67780408
84	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.67753955
85	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.67391540
86	TP53_16413492_ChIP-PET_HCT116_Human	0.66947667
87	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.65556909
88	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.65423196
89	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.65020920
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.64845134
91	ETV1_20927104_ChIP-Seq_GIST48_Human	0.62842102
92	VDR_22108803_ChIP-Seq_LS180_Human	0.62831745
93	AR_20517297_ChIP-Seq_VCAP_Human	0.62637495
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.62294096
95	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.61995839
96	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.61580287
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.61255293
98	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.60638650
99	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.59685760
100	SMC4_20622854_ChIP-Seq_HELA_Human	0.59393972

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	7.77236812
2	MP0002139_abnormal_hepatobiliary_system	7.03749911
3	MP0005360_urolithiasis	6.65771627
4	MP0005365_abnormal_bile_salt	4.84487304
5	MP0005085_abnormal_gallbladder_physiolo	4.58681048
6	MP0004043_abnormal_pH_regulation	4.27818672
7	MP0002138_abnormal_hepatobiliary_system	4.21315099
8	MP0003252_abnormal_bile_duct	3.75076311
9	MP0008875_abnormal_xenobiotic_pharmacok	3.67040714
10	MP0001666_abnormal_nutrient_absorption	3.31156707
11	MP0010329_abnormal_lipoprotein_level	3.02866257
12	MP0004019_abnormal_vitamin_homeostasis	2.71135183
13	MP0005332_abnormal_amino_acid	2.70007551
14	MP0009840_abnormal_foam_cell	2.33392436
15	MP0001756_abnormal_urination	2.15250745
16	MP0000566_synostosis	2.12460050
17	MP0009643_abnormal_urine_homeostasis	2.01078135
18	MP0003283_abnormal_digestive_organ	1.83875083
19	MP0003868_abnormal_feces_composition	1.83272405
20	MP0005670_abnormal_white_adipose	1.68754905
21	MP0005636_abnormal_mineral_homeostasis	1.65537806
22	MP0002118_abnormal_lipid_homeostasis	1.62363288
23	MP0010368_abnormal_lymphatic_system	1.56530901
24	MP0001765_abnormal_ion_homeostasis	1.47341879
25	MP0000609_abnormal_liver_physiology	1.41326992
26	MP0003191_abnormal_cellular_cholesterol	1.41156772
27	MP0003122_maternal_imprinting	1.39688620
28	MP0004264_abnormal_extraembryonic_tissu	1.25128357
29	MP0002136_abnormal_kidney_physiology	1.23938545
30	MP0002876_abnormal_thyroid_physiology	1.23365194
31	MP0002168_other_aberrant_phenotype	1.22397289
32	MP0003879_abnormal_hair_cell	1.19748420
33	MP0001764_abnormal_homeostasis	1.18871147
34	MP0009697_abnormal_copulation	1.09835916
35	MP0002089_abnormal_postnatal_growth/wei	1.04856371
36	MP0002132_abnormal_respiratory_system	1.01581120
37	MP0001661_extended_life_span	0.98310625
38	MP0005220_abnormal_exocrine_pancreas	0.96445587
39	MP0005409_darkened_coat_color	0.95422131
40	MP0003183_abnormal_peptide_metabolism	0.94302221
41	MP0003878_abnormal_ear_physiology	0.92984948
42	MP0005377_hearing/vestibular/ear_phenot	0.92984948
43	MP0005395_other_phenotype	0.92157680
44	MP0005319_abnormal_enzyme/_coenzyme	0.87533007
45	MP0009642_abnormal_blood_homeostasis	0.86140787
46	MP0005408_hypopigmentation	0.83092146
47	MP0001270_distended_abdomen	0.80645684
48	MP0000598_abnormal_liver_morphology	0.79228994
49	MP0002928_abnormal_bile_duct	0.76835352
50	MP0005584_abnormal_enzyme/coenzyme_acti	0.74000927
51	MP0003011_delayed_dark_adaptation	0.73994978
52	MP0005451_abnormal_body_composition	0.73632088
53	MP0002971_abnormal_brown_adipose	0.73466464
54	MP0005084_abnormal_gallbladder_morpholo	0.70697786
55	MP0005058_abnormal_lysosome_morphology	0.70038784
56	MP0003953_abnormal_hormone_level	0.65145293
57	MP0008961_abnormal_basal_metabolism	0.64665425
58	MP0002078_abnormal_glucose_homeostasis	0.64307289
59	MP0000538_abnormal_urinary_bladder	0.63390617
60	MP0008872_abnormal_physiological_respon	0.63156204
61	MP0002909_abnormal_adrenal_gland	0.60784823
62	MP0004272_abnormal_basement_membrane	0.59645982
63	MP0000604_amyloidosis	0.59361685
64	MP0005448_abnormal_energy_balance	0.58949335
65	MP0003943_abnormal_hepatobiliary_system	0.58477700
66	MP0002249_abnormal_larynx_morphology	0.55922107
67	MP0000678_abnormal_parathyroid_gland	0.55867447
68	MP0003123_paternal_imprinting	0.55751613
69	MP0000639_abnormal_adrenal_gland	0.54138845
70	MP0009384_cardiac_valve_regurgitation	0.53140799
71	MP0005083_abnormal_biliary_tract	0.52228924
72	MP0002282_abnormal_trachea_morphology	0.52047834
73	MP0002135_abnormal_kidney_morphology	0.51971439
74	MP0003567_abnormal_fetal_cardiomyocyte	0.51690965
75	MP0001915_intracranial_hemorrhage	0.50317266
76	MP0005666_abnormal_adipose_tissue	0.47391199
77	MP0000462_abnormal_digestive_system	0.46891050
78	MP0009115_abnormal_fat_cell	0.46606361
79	MP0009780_abnormal_chondrocyte_physiolo	0.43686096
80	MP0001664_abnormal_digestion	0.41181162
81	MP0005535_abnormal_body_temperature	0.40759072
82	MP0003172_abnormal_lysosome_physiology	0.40538269
83	MP0001944_abnormal_pancreas_morphology	0.39824568
84	MP0003941_abnormal_skin_development	0.39779606
85	MP0008004_abnormal_stomach_pH	0.39500937
86	MP0000230_abnormal_systemic_arterial	0.38470206
87	MP0005376_homeostasis/metabolism_phenot	0.37408256
88	MP0008469_abnormal_protein_level	0.37133509
89	MP0005334_abnormal_fat_pad	0.37090919
90	MP0003638_abnormal_response/metabolism_	0.35169974
91	MP0000003_abnormal_adipose_tissue	0.33884248
92	MP0005551_abnormal_eye_electrophysiolog	0.33431134
93	MP0003115_abnormal_respiratory_system	0.31737997
94	MP0005375_adipose_tissue_phenotype	0.31360052
95	MP0003119_abnormal_digestive_system	0.29008272
96	MP0002092_abnormal_eye_morphology	0.28912595
97	MP0002896_abnormal_bone_mineralization	0.28581879
98	MP0004782_abnormal_surfactant_physiolog	0.28296375
99	MP0002069_abnormal_eating/drinking_beha	0.27967905
100	MP0006054_spinal_hemorrhage	0.26666788

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	7.17878874
2	Metabolic alkalosis (HP:0200114)	6.97696325
3	Increased circulating renin level (HP:0000848)	6.91639060
4	Hyperactive renin-angiotensin system (HP:0000841)	6.38442459
5	Prolonged partial thromboplastin time (HP:0003645)	6.11384711
6	Complement deficiency (HP:0004431)	5.95249936
7	Hypokalemic alkalosis (HP:0001949)	5.68835044
8	Hypobetalipoproteinemia (HP:0003563)	5.56197693
9	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.51565510
10	Abnormality of chloride homeostasis (HP:0011422)	5.36574705
11	Joint hemorrhage (HP:0005261)	5.05233518
12	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.91752381
13	Hypomagnesemia (HP:0002917)	4.85788885
14	Abnormality of complement system (HP:0005339)	4.61678556
15	Hyperaldosteronism (HP:0000859)	4.61549543
16	Alkalosis (HP:0001948)	4.47132970
17	Xanthomatosis (HP:0000991)	4.44068531
18	Gout (HP:0001997)	4.24656549
19	Systemic lupus erythematosus (HP:0002725)	4.19336416
20	Abnormality of magnesium homeostasis (HP:0004921)	4.13379518
21	Renal salt wasting (HP:0000127)	4.11286774
22	Abnormality of renin-angiotensin system (HP:0000847)	4.09753755
23	Abnormal urine output (HP:0012590)	3.92765725
24	Polyuria (HP:0000103)	3.77514290
25	Glomerulonephritis (HP:0000099)	3.71867979
26	Abnormality of renal excretion (HP:0011036)	3.63277962
27	Hyperlipoproteinemia (HP:0010980)	3.61735327
28	Hypokalemia (HP:0002900)	3.53419566
29	Hypolipoproteinemia (HP:0010981)	3.46773619
30	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.44757891
31	Spontaneous abortion (HP:0005268)	3.41313543
32	Proximal tubulopathy (HP:0000114)	3.38033694
33	Tetany (HP:0001281)	3.26512491
34	Generalized aminoaciduria (HP:0002909)	3.24718638
35	Abnormality of the common coagulation pathway (HP:0010990)	3.15528581
36	Potter facies (HP:0002009)	3.15484522
37	Facial shape deformation (HP:0011334)	3.15484522
38	Conjugated hyperbilirubinemia (HP:0002908)	3.10689928
39	Intrahepatic cholestasis (HP:0001406)	3.08144321
40	Hemorrhage of the eye (HP:0011885)	3.05949277
41	Abnormality of potassium homeostasis (HP:0011042)	2.93371255
42	Vascular calcification (HP:0004934)	2.85284172
43	Rickets (HP:0002748)	2.84047871
44	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.80148846
45	Enlarged kidneys (HP:0000105)	2.73142576
46	Hypercholesterolemia (HP:0003124)	2.65078654
47	Hypercalciuria (HP:0002150)	2.64891915
48	Hypoalphalipoproteinemia (HP:0003233)	2.60946519
49	Osteomalacia (HP:0002749)	2.60797993
50	Hyperphosphaturia (HP:0003109)	2.57019532
51	Glycosuria (HP:0003076)	2.56889936
52	Abnormality of urine glucose concentration (HP:0011016)	2.56889936
53	Abnormality of purine metabolism (HP:0004352)	2.55904280
54	Abnormality of nucleobase metabolism (HP:0010932)	2.54343562
55	Fat malabsorption (HP:0002630)	2.54037896
56	Polydipsia (HP:0001959)	2.53086634
57	Abnormal drinking behavior (HP:0030082)	2.53086634
58	Abnormality of pyrimidine metabolism (HP:0004353)	2.50938359
59	Nephritis (HP:0000123)	2.49764922
60	Epidermoid cyst (HP:0200040)	2.49560744
61	Hypophosphatemic rickets (HP:0004912)	2.49192551
62	Abnormality of glycine metabolism (HP:0010895)	2.48967361
63	Abnormality of serine family amino acid metabolism (HP:0010894)	2.48967361
64	Cardiovascular calcification (HP:0011915)	2.45655699
65	Hyperglycinemia (HP:0002154)	2.44659859
66	Abnormality of carpal bone ossification (HP:0006257)	2.41256169
67	Hyperglycinuria (HP:0003108)	2.41224903
68	Abnormal urine phosphate concentration (HP:0012599)	2.37655617
69	Abnormality of proline metabolism (HP:0010907)	2.37020921
70	Hydroxyprolinuria (HP:0003080)	2.37020921
71	Hyperuricemia (HP:0002149)	2.33643538
72	Increased purine levels (HP:0004368)	2.33643538
73	Hypotension (HP:0002615)	2.27482257
74	Menorrhagia (HP:0000132)	2.27321010
75	Abnormality of fatty-acid metabolism (HP:0004359)	2.24698565
76	Adrenal overactivity (HP:0002717)	2.15499505
77	Recurrent gram-negative bacterial infections (HP:0005420)	2.14645670
78	Abnormality of the intrinsic pathway (HP:0010989)	2.14374550
79	Delayed CNS myelination (HP:0002188)	2.10011108
80	Abnormality of sodium homeostasis (HP:0010931)	2.07970396
81	Chondrocalcinosis (HP:0000934)	2.06257438
82	Focal segmental glomerulosclerosis (HP:0000097)	2.06144168
83	Abnormal tarsal ossification (HP:0008369)	2.05758537
84	Abnormality of Sharpey fibers (HP:0100685)	2.05556694
85	Gingival bleeding (HP:0000225)	2.04873744
86	Hypophosphatemia (HP:0002148)	2.01491516
87	Mitral stenosis (HP:0001718)	2.01465005
88	Abnormality of vitamin metabolism (HP:0100508)	1.98538100
89	Nephrocalcinosis (HP:0000121)	1.92412618
90	Pigmentary retinal degeneration (HP:0001146)	1.90341033
91	Hyponatremia (HP:0002902)	1.88731698
92	Glomerulosclerosis (HP:0000096)	1.86150862
93	Hyperammonemia (HP:0001987)	1.83698632
94	Nephrolithiasis (HP:0000787)	1.83401634
95	Abnormality of alkaline phosphatase activity (HP:0004379)	1.82129066
96	Abnormal hand bone ossification (HP:0010660)	1.80113908
97	Megaloblastic anemia (HP:0001889)	1.79603625
98	Abnormal enzyme/coenzyme activity (HP:0012379)	1.79587314
99	Thrombophlebitis (HP:0004418)	1.78917396
100	Neonatal death (HP:0003811)	1.78383427

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	8.78454188
2	OXSR1	6.51411786
3	WNK4	4.64642367
4	FGFR4	3.93710858
5	STK39	2.87446993
6	LATS1	2.60538088
7	FGFR3	2.32622247
8	ERN1	2.17426953
9	FGFR2	1.98546874
10	SGK2	1.90530623
11	RIPK1	1.89272577
12	SGK223	1.66260134
13	SGK494	1.66260134
14	MST1R	1.58493746
15	SGK3	1.52946489
16	EPHA2	1.51396343
17	ACVR1B	1.45354781
18	MET	1.44819287
19	ICK	1.44474042
20	LMTK2	1.38191842
21	PIK3CA	1.30747006
22	FRK	1.29915911
23	PDK2	1.24386527
24	PRKAA2	1.19380372
25	TYRO3	1.07450246
26	AKT3	1.04082699
27	FGFR1	0.99922701
28	TRIB3	0.99847132
29	NLK	0.98565312
30	MAP3K2	0.95738315
31	MAP3K7	0.94901087
32	WNK1	0.93952482
33	CDK12	0.88932183
34	NTRK3	0.88493973
35	PRKAA1	0.87754686
36	PDGFRA	0.86371257
37	EPHA4	0.85049230
38	DDR2	0.80965304
39	GRK1	0.80754804
40	DYRK1B	0.80630972
41	SIK1	0.80516695
42	ERBB2	0.77382143
43	PDPK1	0.71251947
44	PIK3CG	0.68467914
45	RET	0.65128060
46	INSRR	0.64142950
47	SGK1	0.63879125
48	PRKACG	0.62832584
49	BRSK2	0.62564275
50	CAMKK2	0.62031790
51	MELK	0.55903993
52	PRKG2	0.51445347
53	MAPK11	0.51398638
54	PDGFRB	0.50409988
55	CSF1R	0.49992867
56	DAPK2	0.48719944
57	MAP2K6	0.47820803
58	FGR	0.47111621
59	PTK6	0.47049306
60	PDK1	0.45786699
61	CASK	0.45043219
62	BCR	0.43997027
63	NEK2	0.43512255
64	CAMK1G	0.42121369
65	PRKCG	0.41764116
66	PRPF4B	0.40758829
67	CAMK1D	0.38700629
68	STK38L	0.36402273
69	STK3	0.36025438
70	PRKCZ	0.35927285
71	MAP2K2	0.35644476
72	BMX	0.35009325
73	PKN2	0.32260382
74	MUSK	0.31421587
75	NUAK1	0.30583066
76	CSNK1A1	0.29152542
77	STK38	0.29068873
78	PRKG1	0.29039979
79	PRKACA	0.25796128
80	CSNK1E	0.25652650
81	CDK4	0.25146186
82	SRC	0.25009419
83	MAP2K4	0.24122085
84	PNCK	0.24042907
85	CDC42BPA	0.23675660
86	CDK7	0.23571306
87	RPS6KB1	0.21657880
88	IGF1R	0.20750003
89	PTK2	0.19829957
90	MYLK	0.19552270
91	STK11	0.19475193
92	MAP3K1	0.19345654
93	RPS6KA3	0.19163343
94	MAPK15	0.19042560
95	TYK2	0.18622456
96	DYRK1A	0.16921124
97	MARK2	0.15993101
98	CDK3	0.15991037
99	MATK	0.15905372
100	PRKACB	0.14680467

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.06747772
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.40773924
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.24881537
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.96814292
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.81213211
6	Retinol metabolism_Homo sapiens_hsa00830	2.71787829
7	Caffeine metabolism_Homo sapiens_hsa00232	2.70175354
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.56119414
9	Fatty acid degradation_Homo sapiens_hsa00071	2.56070510
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.54632271
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.51177085
12	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.49503096
13	Histidine metabolism_Homo sapiens_hsa00340	2.44310558
14	Chemical carcinogenesis_Homo sapiens_hsa05204	2.37072274
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.30253018
16	Fat digestion and absorption_Homo sapiens_hsa04975	2.29745791
17	Phenylalanine metabolism_Homo sapiens_hsa00360	2.23835605
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.23789120
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.16378858
20	Bile secretion_Homo sapiens_hsa04976	2.03516684
21	Butanoate metabolism_Homo sapiens_hsa00650	1.96095128
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.86911353
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.85525165
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.84550746
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.79382807
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.77696163
27	Tyrosine metabolism_Homo sapiens_hsa00350	1.72896957
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.64125457
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.64083578
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.57128279
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52089682
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.44184686
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43518879
34	Arginine and proline metabolism_Homo sapiens_hsa00330	1.34084048
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21764048
36	Propanoate metabolism_Homo sapiens_hsa00640	1.19548295
37	ABC transporters_Homo sapiens_hsa02010	1.17049054
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16215079
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.12128110
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11298621
41	Peroxisome_Homo sapiens_hsa04146	1.10117544
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.07329927
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06083392
44	Mineral absorption_Homo sapiens_hsa04978	1.03506536
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01636071
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.00783311
47	Renin-angiotensin system_Homo sapiens_hsa04614	0.93841920
48	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93374826
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86231615
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85711192
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84783347
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83533388
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.80750135
54	Other glycan degradation_Homo sapiens_hsa00511	0.80636511
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78015554
56	Prion diseases_Homo sapiens_hsa05020	0.76587327
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.75875099
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69698137
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.69457264
60	Lysine degradation_Homo sapiens_hsa00310	0.67731950
61	Sulfur metabolism_Homo sapiens_hsa00920	0.66319020
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65108082
63	Carbon metabolism_Homo sapiens_hsa01200	0.58675616
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.55952982
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.53855261
66	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.52128090
67	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52042360
68	Sulfur relay system_Homo sapiens_hsa04122	0.49008656
69	One carbon pool by folate_Homo sapiens_hsa00670	0.47766898
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47527904
71	Galactose metabolism_Homo sapiens_hsa00052	0.47092171
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.44669386
73	Metabolic pathways_Homo sapiens_hsa01100	0.42230801
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41265405
75	Glucagon signaling pathway_Homo sapiens_hsa04922	0.37203978
76	Insulin resistance_Homo sapiens_hsa04931	0.36775826
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32012031
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31438209
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.29975415
80	Glutathione metabolism_Homo sapiens_hsa00480	0.29140600
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27609342
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.27343420
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26906218
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.24470899
85	Pertussis_Homo sapiens_hsa05133	0.22063721
86	Fatty acid elongation_Homo sapiens_hsa00062	0.21460154
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20279787
88	AMPK signaling pathway_Homo sapiens_hsa04152	0.10120544
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.09896239
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.07259159
91	Pancreatic secretion_Homo sapiens_hsa04972	0.06870535
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.05124542
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.03456219
94	ECM-receptor interaction_Homo sapiens_hsa04512	0.01458060
95	Circadian rhythm_Homo sapiens_hsa04710	0.00412764
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	-0.0920591
97	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0795040
98	Choline metabolism in cancer_Homo sapiens_hsa05231	-0.0267783
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	-0.0171423
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0045981

MST1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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