MST1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)8.61816194
2regulation of fibrinolysis (GO:0051917)8.14251860
3protein carboxylation (GO:0018214)7.90213366
4peptidyl-glutamic acid carboxylation (GO:0017187)7.90213366
5regulation of protein activation cascade (GO:2000257)7.57386234
6regulation of complement activation (GO:0030449)7.32457949
7intestinal cholesterol absorption (GO:0030299)6.70183102
8very-low-density lipoprotein particle assembly (GO:0034379)6.64867455
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.59087230
10L-phenylalanine catabolic process (GO:0006559)6.59087230
11complement activation, alternative pathway (GO:0006957)6.57801684
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.44957050
13plasma lipoprotein particle assembly (GO:0034377)6.40551606
14regulation of plasminogen activation (GO:0010755)6.26266574
15plasma lipoprotein particle remodeling (GO:0034369)6.23739226
16protein-lipid complex remodeling (GO:0034368)6.23739226
17macromolecular complex remodeling (GO:0034367)6.23739226
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.18043975
19L-phenylalanine metabolic process (GO:0006558)6.18043975
20cholesterol efflux (GO:0033344)6.16971253
21blood coagulation, intrinsic pathway (GO:0007597)5.98675616
22regulation of cholesterol esterification (GO:0010872)5.92827725
23negative regulation of sterol transport (GO:0032372)5.89352145
24negative regulation of cholesterol transport (GO:0032375)5.89352145
25high-density lipoprotein particle remodeling (GO:0034375)5.82855681
26protein-lipid complex assembly (GO:0065005)5.68445418
27regulation of apoptotic cell clearance (GO:2000425)5.68063099
28low-density lipoprotein particle remodeling (GO:0034374)5.54270351
29plasma lipoprotein particle organization (GO:0071827)5.51529962
30reverse cholesterol transport (GO:0043691)5.46928733
31fibrinolysis (GO:0042730)5.22230198
32protein-lipid complex subunit organization (GO:0071825)5.17594566
33plasma lipoprotein particle clearance (GO:0034381)5.03970482
34phospholipid efflux (GO:0033700)5.00552636
35epoxygenase P450 pathway (GO:0019373)4.93953107
36negative regulation of protein activation cascade (GO:2000258)4.83380221
37acute-phase response (GO:0006953)4.79138769
38positive regulation of triglyceride lipase activity (GO:0061365)4.71477785
39positive regulation of lipoprotein lipase activity (GO:0051006)4.71477785
40glutamate metabolic process (GO:0006536)4.62086506
41protein activation cascade (GO:0072376)4.59063701
42positive regulation of fatty acid biosynthetic process (GO:0045723)4.46529541
43triglyceride homeostasis (GO:0070328)4.44941930
44acylglycerol homeostasis (GO:0055090)4.44941930
45proline metabolic process (GO:0006560)4.40493962
46exogenous drug catabolic process (GO:0042738)4.39920995
47negative regulation of hemostasis (GO:1900047)4.39122611
48negative regulation of blood coagulation (GO:0030195)4.39122611
49regulation of humoral immune response (GO:0002920)4.38983720
50intestinal absorption (GO:0050892)4.38920035
51ethanol oxidation (GO:0006069)4.36342017
52aromatic amino acid family catabolic process (GO:0009074)4.31747511
53imidazole-containing compound metabolic process (GO:0052803)4.29135055
54glyoxylate metabolic process (GO:0046487)4.28764401
55positive regulation of hemostasis (GO:1900048)4.26989690
56positive regulation of blood coagulation (GO:0030194)4.26989690
57complement activation, classical pathway (GO:0006958)4.24988026
58regulation of cholesterol homeostasis (GO:2000188)4.21421390
59drug catabolic process (GO:0042737)4.18363040
60lipoprotein metabolic process (GO:0042157)4.14149631
61positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.13473432
62omega-hydroxylase P450 pathway (GO:0097267)4.11706256
63negative regulation of lipase activity (GO:0060192)4.05265405
64urea metabolic process (GO:0019627)4.03483210
65regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.02252251
66negative regulation of coagulation (GO:0050819)4.01752623
67cholesterol homeostasis (GO:0042632)4.01608432
68regulation of bile acid biosynthetic process (GO:0070857)3.99935596
69sterol homeostasis (GO:0055092)3.95950240
70sterol transport (GO:0015918)3.93780041
71cholesterol transport (GO:0030301)3.93780041
72regulation of triglyceride catabolic process (GO:0010896)3.92458681
73positive regulation of coagulation (GO:0050820)3.89729353
74complement activation (GO:0006956)3.89690260
75negative regulation of complement activation (GO:0045916)3.86449354
76negative regulation of wound healing (GO:0061045)3.85705323
77regulation of cholesterol biosynthetic process (GO:0045540)3.83370249
78serine family amino acid catabolic process (GO:0009071)3.72914760
79urea cycle (GO:0000050)3.67669983
80nitrogen cycle metabolic process (GO:0071941)3.60083981
81ethanol metabolic process (GO:0006067)3.56628484
82diacylglycerol metabolic process (GO:0046339)3.53967095
83cytolysis (GO:0019835)3.52526923
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.52014464
85tyrosine metabolic process (GO:0006570)3.49954565
86positive regulation of steroid metabolic process (GO:0045940)3.48626326
87positive regulation of extracellular matrix organization (GO:1903055)3.46959908
88acute inflammatory response (GO:0002526)3.44642408
89peptidyl-glutamic acid modification (GO:0018200)3.41142358
90lipid homeostasis (GO:0055088)3.39182966
91bile acid metabolic process (GO:0008206)3.39157501
92negative regulation of digestive system process (GO:0060457)3.30069078
93regulation of fatty acid biosynthetic process (GO:0042304)3.29164851
94regulation of cholesterol metabolic process (GO:0090181)3.26439947
95glycine metabolic process (GO:0006544)3.22102795
96killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.20714828
97disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.20714828
98negative regulation of lipid transport (GO:0032369)3.19318704
99drug metabolic process (GO:0017144)3.18562535
100positive regulation of lipid catabolic process (GO:0050996)3.15127795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.16999495
2PPARA_22158963_ChIP-Seq_LIVER_Mouse5.29237353
3LXR_22158963_ChIP-Seq_LIVER_Mouse4.84930013
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.31301768
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.30891833
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22085238
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.17247150
8FOXA2_19822575_ChIP-Seq_HepG2_Human3.62952957
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57076026
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.35366961
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.19964153
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.87845486
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.64709668
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.36489282
15ZNF263_19887448_ChIP-Seq_K562_Human2.34570409
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.27413855
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00652755
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5906123
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85894955
20CLOCK_20551151_ChIP-Seq_293T_Human1.80223372
21LXR_22292898_ChIP-Seq_THP-1_Human1.74520328
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59970608
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59757533
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56492209
25SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.52237833
26SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.45750616
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.42727087
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.38769982
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36274920
30GATA4_25053715_ChIP-Seq_YYC3_Human1.35252554
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32753615
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26154441
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21086989
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.19737179
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.18638058
36RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15256212
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12332295
38* GATA6_25053715_ChIP-Seq_YYC3_Human1.09973782
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08439717
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07835956
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.06762280
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06533623
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.05386054
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05036880
45RARA_24833708_ChIP-Seq_LIVER_Mouse1.04242449
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03726323
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03539264
48GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00952299
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.00008439
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98961854
51* SMC4_20622854_ChIP-Seq_HELA_Human0.97886260
52RARB_24833708_ChIP-Seq_LIVER_Mouse0.97285406
53POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95886465
54* RACK7_27058665_Chip-Seq_MCF-7_Human0.94040300
55P68_20966046_ChIP-Seq_HELA_Human0.93777217
56STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93015157
57NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87692290
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86309143
59ESR1_20079471_ChIP-ChIP_T-47D_Human0.86232083
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81530753
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80151091
62RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80065980
63ELF1_20517297_ChIP-Seq_JURKAT_Human0.78493546
64NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.77320401
65GATA1_19941827_ChIP-Seq_MEL_Mouse0.77230489
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77009503
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75530313
68ESR1_21235772_ChIP-Seq_MCF-7_Human0.74968143
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74611235
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73635926
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73594448
72JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73370100
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73285376
74E2F1_20622854_ChIP-Seq_HELA_Human0.73119628
75TP53_22127205_ChIP-Seq_IMR90_Human0.72889721
76KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72883271
77* RAC3_21632823_ChIP-Seq_H3396_Human0.71686366
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70178920
79SOX11_22085726_ChIP-Seq_ESNs_Mouse0.69422768
80TET1_21451524_ChIP-Seq_MESCs_Mouse0.68871059
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68856956
82ZFP281_18757296_ChIP-ChIP_E14_Mouse0.68580181
83MYC_19915707_ChIP-ChIP_AK7_Human0.67563474
84SPI1_26923725_Chip-Seq_HPCs_Mouse0.67062469
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67029036
86BCOR_27268052_Chip-Seq_Bcells_Human0.66672622
87CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66452344
88MYC_27129775_Chip-Seq_CORNEA_Mouse0.64748984
89KDM2B_26808549_Chip-Seq_K562_Human0.63703585
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.63155148
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63136936
92* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62116714
93SOX2_20726797_ChIP-Seq_SW620_Human0.61813517
94* CTCF_27219007_Chip-Seq_Bcells_Human0.61397986
95PHF8_20622854_ChIP-Seq_HELA_Human0.60763950
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.60593855
97SOX2_21211035_ChIP-Seq_LN229_Human0.60252324
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.59984352
99* CREB1_26743006_Chip-Seq_LNCaP_Human0.59743491
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59268975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.64214059
2MP0005360_urolithiasis7.45478267
3MP0005365_abnormal_bile_salt5.39664023
4MP0003195_calcinosis5.38622786
5MP0008875_abnormal_xenobiotic_pharmacok4.71048990
6MP0005085_abnormal_gallbladder_physiolo4.70854819
7MP0010329_abnormal_lipoprotein_level3.90971243
8MP0001666_abnormal_nutrient_absorption3.72947762
9MP0003122_maternal_imprinting3.24537923
10MP0003252_abnormal_bile_duct3.24385383
11MP0000566_synostosis2.67090493
12MP0009840_abnormal_foam_cell2.41936121
13MP0003868_abnormal_feces_composition2.10532942
14MP0005332_abnormal_amino_acid2.03893813
15MP0003172_abnormal_lysosome_physiology1.98191990
16MP0000609_abnormal_liver_physiology1.95083196
17MP0002089_abnormal_postnatal_growth/wei1.89442967
18MP0002118_abnormal_lipid_homeostasis1.87887992
19MP0003191_abnormal_cellular_cholesterol1.86173726
20MP0005451_abnormal_body_composition1.82151693
21MP0002138_abnormal_hepatobiliary_system1.81693624
22MP0010368_abnormal_lymphatic_system1.73371240
23MP0005408_hypopigmentation1.68609545
24MP0005058_abnormal_lysosome_morphology1.63012151
25MP0001915_intracranial_hemorrhage1.58495936
26MP0002132_abnormal_respiratory_system1.56696294
27MP0003123_paternal_imprinting1.54261092
28MP0001661_extended_life_span1.38329389
29MP0005670_abnormal_white_adipose1.20562552
30MP0004019_abnormal_vitamin_homeostasis1.18914987
31MP0000598_abnormal_liver_morphology1.18420163
32MP0002876_abnormal_thyroid_physiology1.14549362
33MP0001764_abnormal_homeostasis1.14260870
34MP0005409_darkened_coat_color1.12841841
35MP0003656_abnormal_erythrocyte_physiolo1.06865388
36MP0005319_abnormal_enzyme/_coenzyme1.01720853
37MP0009780_abnormal_chondrocyte_physiolo1.01493244
38MP0000604_amyloidosis0.97561058
39MP0009697_abnormal_copulation0.97550378
40MP0000639_abnormal_adrenal_gland0.94976799
41MP0009642_abnormal_blood_homeostasis0.92845963
42MP0005636_abnormal_mineral_homeostasis0.91827035
43MP0009643_abnormal_urine_homeostasis0.88920407
44MP0005464_abnormal_platelet_physiology0.88416875
45MP0002971_abnormal_brown_adipose0.83663276
46MP0003879_abnormal_hair_cell0.82006524
47MP0005257_abnormal_intraocular_pressure0.80317445
48MP0009384_cardiac_valve_regurgitation0.79693387
49MP0005167_abnormal_blood-brain_barrier0.78016472
50MP0004272_abnormal_basement_membrane0.76940355
51MP0006054_spinal_hemorrhage0.76781509
52MP0005084_abnormal_gallbladder_morpholo0.75936898
53MP0005584_abnormal_enzyme/coenzyme_acti0.74181428
54MP0002249_abnormal_larynx_morphology0.70783213
55MP0000678_abnormal_parathyroid_gland0.70498147
56MP0003878_abnormal_ear_physiology0.70216795
57MP0005377_hearing/vestibular/ear_phenot0.70216795
58MP0002078_abnormal_glucose_homeostasis0.68890530
59MP0008260_abnormal_autophagy0.68226007
60MP0002282_abnormal_trachea_morphology0.66734045
61MP0003121_genomic_imprinting0.64713134
62MP0003115_abnormal_respiratory_system0.64466685
63MP0004264_abnormal_extraembryonic_tissu0.61758321
64MP0008469_abnormal_protein_level0.60730848
65MP0009115_abnormal_fat_cell0.59959655
66MP0005220_abnormal_exocrine_pancreas0.59900683
67MP0006292_abnormal_olfactory_placode0.59556668
68MP0005448_abnormal_energy_balance0.58873760
69MP0005076_abnormal_cell_differentiation0.57339720
70MP0000003_abnormal_adipose_tissue0.56705266
71MP0003806_abnormal_nucleotide_metabolis0.56542097
72MP0003567_abnormal_fetal_cardiomyocyte0.56444790
73MP0003329_amyloid_beta_deposits0.56318568
74MP0003183_abnormal_peptide_metabolism0.55707714
75MP0002933_joint_inflammation0.55212986
76MP0002092_abnormal_eye_morphology0.54483773
77MP0003011_delayed_dark_adaptation0.51552345
78MP0005395_other_phenotype0.51077566
79MP0003953_abnormal_hormone_level0.50807561
80MP0003315_abnormal_perineum_morphology0.50453170
81MP0001270_distended_abdomen0.49868587
82MP0009763_increased_sensitivity_to0.49522145
83MP0002909_abnormal_adrenal_gland0.47202486
84MP0005376_homeostasis/metabolism_phenot0.47157624
85MP0001756_abnormal_urination0.45827730
86MP0000858_altered_metastatic_potential0.45756026
87MP0002168_other_aberrant_phenotype0.45124623
88MP0003950_abnormal_plasma_membrane0.43890171
89MP0003566_abnormal_cell_adhesion0.43243538
90MP0005083_abnormal_biliary_tract0.43023276
91MP0005164_abnormal_response_to0.42872570
92MP0005334_abnormal_fat_pad0.42323230
93MP0002970_abnormal_white_adipose0.41658359
94MP0005023_abnormal_wound_healing0.41355838
95MP0004883_abnormal_blood_vessel0.41114852
96MP0003942_abnormal_urinary_system0.39280962
97MP0003690_abnormal_glial_cell0.38167200
98MP0000249_abnormal_blood_vessel0.37993175
99MP0003943_abnormal_hepatobiliary_system0.36874110
100MP0003632_abnormal_nervous_system0.35668675

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)8.54070958
2Complement deficiency (HP:0004431)7.72143107
3Joint hemorrhage (HP:0005261)7.56257001
4Hypobetalipoproteinemia (HP:0003563)6.88371079
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.47093835
6Abnormality of complement system (HP:0005339)6.03546682
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.85892446
8Xanthomatosis (HP:0000991)5.47316531
9Systemic lupus erythematosus (HP:0002725)5.31366426
10Abnormality of the common coagulation pathway (HP:0010990)5.03447110
11Glomerulonephritis (HP:0000099)4.98107618
12Hemorrhage of the eye (HP:0011885)4.47738013
13Hypercholesterolemia (HP:0003124)4.47677854
14Spontaneous abortion (HP:0005268)4.41811132
15Hypolipoproteinemia (HP:0010981)4.39843320
16Conjugated hyperbilirubinemia (HP:0002908)4.19777978
17Hyperlipoproteinemia (HP:0010980)4.12350607
18Menorrhagia (HP:0000132)3.72949052
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.47960531
20Hypoalphalipoproteinemia (HP:0003233)3.37452680
21Intrahepatic cholestasis (HP:0001406)3.28757253
22Purpura (HP:0000979)3.19833394
23Vascular calcification (HP:0004934)3.15753519
24Epidermoid cyst (HP:0200040)3.14836332
25Gingival bleeding (HP:0000225)3.13246287
26Abnormality of the intrinsic pathway (HP:0010989)3.07002669
27Recurrent gram-negative bacterial infections (HP:0005420)2.97655986
28Mitral stenosis (HP:0001718)2.94273897
29Nephritis (HP:0000123)2.92570669
30Abnormality of carpal bone ossification (HP:0006257)2.87737273
31Cardiovascular calcification (HP:0011915)2.75318439
32Hypophosphatemic rickets (HP:0004912)2.69546535
33Thrombophlebitis (HP:0004418)2.68356322
34Acanthocytosis (HP:0001927)2.57480337
35Myocardial infarction (HP:0001658)2.55148065
36Fat malabsorption (HP:0002630)2.51151995
37Hepatocellular carcinoma (HP:0001402)2.50607810
38Broad alveolar ridges (HP:0000187)2.44349604
39Abnormal tarsal ossification (HP:0008369)2.40578557
40Hyperglycinemia (HP:0002154)2.39790216
41Small epiphyses (HP:0010585)2.36513109
42Rickets (HP:0002748)2.33739340
43Osteomalacia (HP:0002749)2.29585295
44Vaginal fistula (HP:0004320)2.28420680
45Enlarged kidneys (HP:0000105)2.28329621
46Abnormality of pyrimidine metabolism (HP:0004353)2.21591045
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19041496
48Skin nodule (HP:0200036)2.16368447
49Abnormality of serine family amino acid metabolism (HP:0010894)2.14209138
50Abnormality of glycine metabolism (HP:0010895)2.14209138
51Abnormal ossification of hand bones (HP:0005921)2.10756996
52Flat acetabular roof (HP:0003180)2.09973821
53Asymmetry of the thorax (HP:0001555)2.08737120
54Abnormal hand bone ossification (HP:0010660)2.07812597
55Facial shape deformation (HP:0011334)2.05610898
56Potter facies (HP:0002009)2.05610898
57Pulmonary embolism (HP:0002204)2.00555757
58Arthropathy (HP:0003040)2.00248185
59Gout (HP:0001997)2.00182594
60Deep venous thrombosis (HP:0002625)11.3485709
61Pancreatic islet-cell hyperplasia (HP:0004510)1.99963096
62Bifid scrotum (HP:0000048)1.97974764
63Broad palm (HP:0001169)1.97028827
64Poikilocytosis (HP:0004447)1.96378950
65Abnormality of methionine metabolism (HP:0010901)1.95873813
66Abnormality of the lumbar spine (HP:0100712)1.95317803
67Delayed CNS myelination (HP:0002188)1.94640116
68Hyperglycinuria (HP:0003108)1.88646726
69Increased serum pyruvate (HP:0003542)1.86542163
70Generalized aminoaciduria (HP:0002909)1.83699179
71Flared iliac wings (HP:0002869)1.82181042
72Widely patent fontanelles and sutures (HP:0004492)1.80678908
73Protrusio acetabuli (HP:0003179)1.80290981
74Epiphyseal dysplasia (HP:0002656)1.78806545
75Abnormality of the Achilles tendon (HP:0005109)1.78519618
76Hepatoblastoma (HP:0002884)1.78312147
77Hyperammonemia (HP:0001987)1.78256914
78Abnormality of proline metabolism (HP:0010907)1.77031303
79Hydroxyprolinuria (HP:0003080)1.77031303
80Alacrima (HP:0000522)1.73756628
81Amyloidosis (HP:0011034)1.72900371
82Abnormal delivery (HP:0001787)1.72887407
83Hypoglycemic coma (HP:0001325)1.71837919
84Abnormality of glycolysis (HP:0004366)1.69717259
85Epistaxis (HP:0000421)1.68708861
86Pigmentary retinal degeneration (HP:0001146)1.68270267
87Gonadal dysgenesis (HP:0000133)1.63581270
88Neonatal death (HP:0003811)1.63038893
89Abnormal gallbladder physiology (HP:0012438)1.63016059
90Cholecystitis (HP:0001082)1.63016059
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61156897
92Abnormality of the nasal septum (HP:0000419)1.60330536
93Urinary glycosaminoglycan excretion (HP:0003541)1.58692124
94Mucopolysacchariduria (HP:0008155)1.58692124
95Abnormality of pain sensation (HP:0010832)1.56977375
96Impaired pain sensation (HP:0007328)1.56977375
97Reticulocytosis (HP:0001923)1.56886001
98Abnormality of the vitreous humor (HP:0004327)1.53206756
99Bronchomalacia (HP:0002780)1.51810896
100Abnormality of nucleobase metabolism (HP:0010932)1.51068300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR47.86338532
2FGFR34.61705509
3ICK3.82327887
4WNK43.71457781
5ERN13.57944386
6TRIB33.07752851
7RIPK12.65731287
8CDK122.55837557
9TYRO32.52749236
10SIK12.33597418
11FGFR22.18920558
12PDGFRA2.16676904
13FGFR11.93139151
14DYRK1B1.86334626
15PKN21.80135141
16PIK3CA1.71139015
17SIK21.64843966
18DDR21.56926568
19WNK11.56724038
20EEF2K1.53898777
21PRKAA21.43080660
22MAPK111.41165807
23RET1.33359315
24EPHA21.26777982
25PDPK11.26234159
26AKT31.25908083
27SMG11.17957846
28FGR1.06013967
29IRAK31.04693869
30ERBB21.03108547
31MAP3K70.98159688
32LATS10.97950413
33NTRK30.94495702
34CDK70.94195176
35PDK10.91353270
36MAP3K20.87116353
37CSF1R0.83035852
38TYK20.82941564
39CDC42BPA0.80381360
40MAP2K30.79373356
41PRKAA10.76665910
42TGFBR20.72958011
43SGK2230.72133825
44SGK4940.72133825
45MAP2K60.71480636
46NEK90.69913382
47MATK0.68106303
48NEK20.66934112
49MAP3K30.65391331
50MTOR0.65182701
51PTK60.63819771
52RPS6KB10.62713246
53MAP3K110.61742906
54EIF2AK10.60747056
55MST1R0.60371893
56EPHA40.60343335
57SGK30.60281634
58PRKACG0.59499308
59MARK20.58260208
60MAP3K10.58002935
61MET0.57887665
62SGK10.56226039
63CDK40.55549186
64CAMK1D0.53696968
65MAPKAPK30.53165481
66PTK20.51850612
67CSNK1E0.51116671
68KSR20.49905078
69MAP2K40.44533933
70PDGFRB0.44386328
71GRK60.43458872
72PRKCZ0.39420822
73BRSK10.38278524
74IGF1R0.37475774
75SRC0.36978341
76BRD40.36873827
77SGK20.36641083
78FLT30.31974424
79NTRK20.30377387
80CDK80.30225435
81MAP3K50.30062726
82MAPK30.29954081
83CSNK1D0.28360780
84CAMK1G0.27272080
85LATS20.26764409
86CDK60.26409008
87CDK90.25898745
88PRPF4B0.25679508
89MELK0.24796485
90RPS6KA30.23914529
91MAP3K60.23430069
92CAMK40.22687690
93ITK0.20815088
94ZAP700.20276145
95EPHB10.20079380
96MAPK10.19999623
97TAOK20.19995978
98CSNK2A20.19442675
99MAP3K130.19083505
100PRKG10.18723763

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046105.29735156
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.55748286
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.84302835
4Arginine biosynthesis_Homo sapiens_hsa002202.75557833
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71187336
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58229863
7Phenylalanine metabolism_Homo sapiens_hsa003602.47384729
8Fatty acid degradation_Homo sapiens_hsa000712.43695664
9Caffeine metabolism_Homo sapiens_hsa002322.43384037
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34233981
11Retinol metabolism_Homo sapiens_hsa008302.31852384
12Histidine metabolism_Homo sapiens_hsa003402.14965612
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13223905
14Fat digestion and absorption_Homo sapiens_hsa049752.10430475
15Tyrosine metabolism_Homo sapiens_hsa003502.03343430
16Chemical carcinogenesis_Homo sapiens_hsa052042.00153859
17PPAR signaling pathway_Homo sapiens_hsa033201.95814067
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.95435048
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93099596
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92000556
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.80995685
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.74147625
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72337876
24Staphylococcus aureus infection_Homo sapiens_hsa051501.70515350
25Bile secretion_Homo sapiens_hsa049761.69580981
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63499067
27Butanoate metabolism_Homo sapiens_hsa006501.59395276
28Steroid biosynthesis_Homo sapiens_hsa001001.58389901
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54661687
30Starch and sucrose metabolism_Homo sapiens_hsa005001.53983465
31Other glycan degradation_Homo sapiens_hsa005111.53103661
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48152984
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.39586528
34Vitamin B6 metabolism_Homo sapiens_hsa007501.38681519
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38549091
36Fatty acid metabolism_Homo sapiens_hsa012121.34796777
37Vitamin digestion and absorption_Homo sapiens_hsa049771.34548565
38Biosynthesis of amino acids_Homo sapiens_hsa012301.32134025
39ABC transporters_Homo sapiens_hsa020101.29258604
40Arginine and proline metabolism_Homo sapiens_hsa003301.28308803
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22754974
42Prion diseases_Homo sapiens_hsa050201.22540653
43Tryptophan metabolism_Homo sapiens_hsa003801.22204565
44Peroxisome_Homo sapiens_hsa041461.11719683
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09151794
46Fatty acid biosynthesis_Homo sapiens_hsa000611.09033470
47Pyruvate metabolism_Homo sapiens_hsa006201.07404290
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.06919091
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02982580
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02427758
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92139410
52One carbon pool by folate_Homo sapiens_hsa006700.90028627
53Carbon metabolism_Homo sapiens_hsa012000.87617951
54Propanoate metabolism_Homo sapiens_hsa006400.83777034
55Linoleic acid metabolism_Homo sapiens_hsa005910.83732570
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.81545816
57beta-Alanine metabolism_Homo sapiens_hsa004100.79623522
58Fructose and mannose metabolism_Homo sapiens_hsa000510.72966406
59Lysine degradation_Homo sapiens_hsa003100.71309945
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70089406
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65600093
62Galactose metabolism_Homo sapiens_hsa000520.63453293
63Glycerolipid metabolism_Homo sapiens_hsa005610.62755902
64Renin-angiotensin system_Homo sapiens_hsa046140.60530872
65Arachidonic acid metabolism_Homo sapiens_hsa005900.59075313
66Insulin resistance_Homo sapiens_hsa049310.57744063
67Sulfur relay system_Homo sapiens_hsa041220.54890601
68Pertussis_Homo sapiens_hsa051330.51608243
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.50881397
70N-Glycan biosynthesis_Homo sapiens_hsa005100.48856065
71Glucagon signaling pathway_Homo sapiens_hsa049220.45689063
72Mineral absorption_Homo sapiens_hsa049780.41342267
73Metabolic pathways_Homo sapiens_hsa011000.39947357
74Fatty acid elongation_Homo sapiens_hsa000620.34104345
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33806939
76Thyroid hormone synthesis_Homo sapiens_hsa049180.29528417
77AMPK signaling pathway_Homo sapiens_hsa041520.28574777
78Sphingolipid metabolism_Homo sapiens_hsa006000.28511656
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24600117
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.23670096
81Pentose phosphate pathway_Homo sapiens_hsa000300.22104128
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21737182
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19857845
84Insulin signaling pathway_Homo sapiens_hsa049100.18198523
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17977829
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16103612
87Sulfur metabolism_Homo sapiens_hsa009200.15249870
88Nitrogen metabolism_Homo sapiens_hsa009100.10018691
89Glutathione metabolism_Homo sapiens_hsa004800.09742289
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.09713609
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08876880
92ECM-receptor interaction_Homo sapiens_hsa045120.07597933
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05678164
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03364671
95African trypanosomiasis_Homo sapiens_hsa05143-0.0817504
96Non-small cell lung cancer_Homo sapiens_hsa05223-0.0730204
97Amoebiasis_Homo sapiens_hsa05146-0.0380180
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0286666
99Selenocompound metabolism_Homo sapiens_hsa00450-0.0126562
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0059779

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