MSTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)9.95386464
2actin-mediated cell contraction (GO:0070252)9.75304720
3muscle cell fate commitment (GO:0042693)8.36104294
4skeletal muscle fiber development (GO:0048741)8.13971499
5* skeletal muscle adaptation (GO:0043501)7.83821842
6actin filament-based movement (GO:0030048)7.26017604
7glycogen catabolic process (GO:0005980)6.93859385
8myotube cell development (GO:0014904)6.93538478
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.89108321
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.68462188
11regulation of sarcomere organization (GO:0060297)6.51295777
12glucan catabolic process (GO:0009251)6.48862816
13striated muscle contraction (GO:0006941)6.27529848
14sarcomere organization (GO:0045214)6.26842843
15creatine metabolic process (GO:0006600)6.22443514
16negative regulation of nitric-oxide synthase activity (GO:0051001)6.18499692
17carnitine shuttle (GO:0006853)6.14919659
18plasma membrane repair (GO:0001778)6.13979562
19cellular polysaccharide catabolic process (GO:0044247)5.99672609
20negative regulation of potassium ion transmembrane transport (GO:1901380)5.98070041
21cardiac myofibril assembly (GO:0055003)5.87987998
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.86400303
23polysaccharide catabolic process (GO:0000272)5.80430181
24response to inactivity (GO:0014854)5.75278683
25membrane raft organization (GO:0031579)5.65965763
26regulation of cell communication by electrical coupling (GO:0010649)5.58530192
27regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.56261361
28purine nucleotide salvage (GO:0032261)5.53189703
29myofibril assembly (GO:0030239)5.34729904
30negative regulation of protein localization to cell surface (GO:2000009)5.34715457
31pyrimidine ribonucleoside catabolic process (GO:0046133)5.33754181
32muscle contraction (GO:0006936)5.25694971
33membrane assembly (GO:0071709)5.16919460
34fatty acid transmembrane transport (GO:1902001)5.13858580
35cytidine deamination (GO:0009972)5.11260801
36cytidine metabolic process (GO:0046087)5.11260801
37cytidine catabolic process (GO:0006216)5.11260801
38glycogen biosynthetic process (GO:0005978)5.04592423
39glucan biosynthetic process (GO:0009250)5.04592423
40muscle fiber development (GO:0048747)4.89191793
41positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.82927140
42glycogen metabolic process (GO:0005977)4.64972499
43* muscle system process (GO:0003012)4.59182145
44cellular glucan metabolic process (GO:0006073)4.55400092
45glucan metabolic process (GO:0044042)4.55400092
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.55131263
47IMP metabolic process (GO:0046040)4.50200729
48carnitine transmembrane transport (GO:1902603)4.45794817
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.45622402
50musculoskeletal movement (GO:0050881)4.41879734
51multicellular organismal movement (GO:0050879)4.41879734
52syncytium formation by plasma membrane fusion (GO:0000768)4.34772553
53neuronal action potential propagation (GO:0019227)4.32816135
54actomyosin structure organization (GO:0031032)4.29518636
55striated muscle tissue development (GO:0014706)4.23598963
56regulation of acyl-CoA biosynthetic process (GO:0050812)4.19149059
57negative regulation of organelle assembly (GO:1902116)4.17958383
58* striated muscle adaptation (GO:0014888)4.15071857
59* skeletal muscle tissue regeneration (GO:0043403)4.11672891
60neuromuscular synaptic transmission (GO:0007274)4.10589516
61amino-acid betaine transport (GO:0015838)4.05039725
62carnitine transport (GO:0015879)4.05039725
63* response to muscle activity (GO:0014850)3.99213835
64muscle cell cellular homeostasis (GO:0046716)3.90405375
65muscle tissue development (GO:0060537)3.81835360
66regulation of cofactor metabolic process (GO:0051193)3.80703798
67regulation of coenzyme metabolic process (GO:0051196)3.80703798
68regulation of skeletal muscle cell differentiation (GO:2001014)3.76204153
69cellular carbohydrate catabolic process (GO:0044275)3.74685172
70negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71776818
71myotube differentiation (GO:0014902)3.71377979
72negative regulation of monooxygenase activity (GO:0032769)3.69048659
73muscle tissue morphogenesis (GO:0060415)3.65290701
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.64033504
75regulation of cardiac muscle cell differentiation (GO:2000725)3.59693515
76* negative regulation of muscle hypertrophy (GO:0014741)3.59637108
77negative regulation of cardiac muscle hypertrophy (GO:0010614)3.59637108
78syncytium formation (GO:0006949)3.58746318
79cardiac muscle contraction (GO:0060048)3.53845573
80striated muscle cell development (GO:0055002)3.50049659
81* muscle organ development (GO:0007517)3.49203141
82regulation of membrane repolarization (GO:0060306)3.47618985
83positive regulation of skeletal muscle tissue development (GO:0048643)3.47063975
84regulation of relaxation of muscle (GO:1901077)3.44689341
85* muscle structure development (GO:0061061)3.43755000
86regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.42651361
87* striated muscle atrophy (GO:0014891)3.40019380
88negative regulation of heart growth (GO:0061117)3.39028125
89negative regulation of cardiac muscle tissue growth (GO:0055022)3.39028125
90IMP biosynthetic process (GO:0006188)3.36793891
91* muscle adaptation (GO:0043500)3.36357112
92regulation of calcium ion transmembrane transport (GO:1903169)3.35652365
93regulation of calcium ion transmembrane transporter activity (GO:1901019)3.35652365
94regulation of sequestering of calcium ion (GO:0051282)3.34944078
95skeletal muscle tissue development (GO:0007519)3.31334043
96negative regulation of cell size (GO:0045792)3.30495924
97generation of neurons (GO:0048699)3.30321952
98positive regulation of striated muscle cell differentiation (GO:0051155)3.30186017
99positive regulation of myoblast differentiation (GO:0045663)3.28724803
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27997256
101metanephric mesenchyme development (GO:0072075)3.27011659
102organ induction (GO:0001759)3.25653954
103* response to activity (GO:0014823)3.25025038
104tricarboxylic acid cycle (GO:0006099)3.24990332
105epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.23099001
106cellular polysaccharide metabolic process (GO:0044264)3.21176720
107regulation of muscle adaptation (GO:0043502)3.19418150
108positive regulation of muscle cell differentiation (GO:0051149)3.16746298
109neuromuscular junction development (GO:0007528)3.14382261
110regulation of striated muscle contraction (GO:0006942)3.11635819
111myoblast fusion (GO:0007520)3.11517980
112heart process (GO:0003015)3.10494126
113heart contraction (GO:0060047)3.10494126
114synaptic transmission, cholinergic (GO:0007271)3.08944375
115positive regulation of myotube differentiation (GO:0010831)3.07489560
116regulation of sulfur metabolic process (GO:0042762)3.05146541
117regulation of alkaline phosphatase activity (GO:0010692)3.04730168
118endoplasmic reticulum organization (GO:0007029)3.03712864
119cardiac muscle cell development (GO:0055013)3.02610829
120polysaccharide metabolic process (GO:0005976)3.01385061
121intracellular lipid transport (GO:0032365)3.01062152
122calcium ion transport into cytosol (GO:0060402)2.99850203
123cardiac muscle tissue morphogenesis (GO:0055008)2.98532187
124regulation of transforming growth factor beta2 production (GO:0032909)2.98299790
125muscle cell development (GO:0055001)2.97841314
126regulation of actin filament-based movement (GO:1903115)2.97602109
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96385525
128* muscle atrophy (GO:0014889)2.96264639
129regulation of p38MAPK cascade (GO:1900744)2.95728502
130positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.92663027
131actin filament depolymerization (GO:0030042)2.92508216
132cellular polysaccharide biosynthetic process (GO:0033692)2.92379436
133cytosolic calcium ion transport (GO:0060401)2.92038494
134regulation of myoblast differentiation (GO:0045661)2.91333522
135positive regulation of microtubule polymerization (GO:0031116)2.91248916
136prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.90770754
137regulation of integrin-mediated signaling pathway (GO:2001044)2.89901672
138polysaccharide biosynthetic process (GO:0000271)2.89439269
139regulation of metalloenzyme activity (GO:0048552)2.89169812
140regulation of action potential (GO:0098900)2.88068976
141fatty acid homeostasis (GO:0055089)2.87835551
142kidney mesenchyme development (GO:0072074)2.87418902
143* regulation of muscle system process (GO:0090257)2.87048556
144anterior/posterior axis specification, embryo (GO:0008595)2.86702216
145cardiac cell development (GO:0055006)2.84463260
146regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81315256
147actin-myosin filament sliding (GO:0033275)11.9507339
148muscle filament sliding (GO:0030049)11.9507339
149regulation of skeletal muscle contraction (GO:0014819)11.7884614
150skeletal muscle contraction (GO:0003009)10.5649989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.38943217
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.88377053
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79377619
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.66736998
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10452494
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.95091909
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.77283696
8AR_21572438_ChIP-Seq_LNCaP_Human2.66370600
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.58674015
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.44034236
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41006782
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.39954252
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39731398
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34751435
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.30758199
16EZH2_22144423_ChIP-Seq_EOC_Human2.30248226
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.27410598
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21217470
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13827891
20FUS_26573619_Chip-Seq_HEK293_Human2.11906423
21GATA1_22025678_ChIP-Seq_K562_Human2.08018278
22GBX2_23144817_ChIP-Seq_PC3_Human2.05249540
23PIAS1_25552417_ChIP-Seq_VCAP_Human2.02688181
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.02301124
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91759186
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87140607
27ZNF263_19887448_ChIP-Seq_K562_Human1.85466378
28TAF15_26573619_Chip-Seq_HEK293_Human1.82017763
29* TBX20_22328084_ChIP-Seq_HEART_Mouse1.79542323
30* TBX20_22080862_ChIP-Seq_HEART_Mouse1.79542323
31CJUN_26792858_Chip-Seq_BT549_Human1.79377055
32DROSHA_22980978_ChIP-Seq_HELA_Human1.79314900
33BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.76998102
34ZNF274_21170338_ChIP-Seq_K562_Hela1.74814721
35CTCF_27219007_Chip-Seq_Bcells_Human1.74587307
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.72604434
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69736546
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68975457
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67341774
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60089386
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58193760
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57651854
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.57212662
44VDR_22108803_ChIP-Seq_LS180_Human1.56007725
45TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.54992300
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54845275
47BRD4_25478319_ChIP-Seq_HGPS_Human1.54751789
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53555556
49SMAD4_21799915_ChIP-Seq_A2780_Human1.52817460
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52237156
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52237156
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51576012
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50470345
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50031690
55PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.49805711
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.48890896
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48598161
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48377256
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45883377
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45219393
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43860407
62KDM2B_26808549_Chip-Seq_REH_Human1.43381473
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43037470
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39120397
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.38319979
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35091434
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34373766
68MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30975798
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30124088
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.29955180
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.29936005
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28623938
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.28551464
74ER_23166858_ChIP-Seq_MCF-7_Human1.28391516
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28111577
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27216082
77* P53_22387025_ChIP-Seq_ESCs_Mouse1.25076668
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24385668
79* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23050513
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.22509874
81* FLI1_27457419_Chip-Seq_LIVER_Mouse1.22288390
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22283745
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22184197
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20151226
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20151226
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20151226
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19958675
88* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16914741
89OCT4_20526341_ChIP-Seq_ESCs_Human1.15528478
90* E2F1_18555785_Chip-Seq_ESCs_Mouse1.15236238
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15013598
92* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14723272
93BCAT_22108803_ChIP-Seq_LS180_Human1.14408429
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14396596
95TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14118432
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.14038875
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14007749
98FOXH1_21741376_ChIP-Seq_ESCs_Human1.13096199
99* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12709069
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12590405
101* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11789324
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.11457164
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11010360
104* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10610197
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09661192
106SA1_27219007_Chip-Seq_Bcells_Human1.09273594
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08774868
108CBP_20019798_ChIP-Seq_JUKART_Human1.08774868
109* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08262707
110STAT3_23295773_ChIP-Seq_U87_Human1.07590573
111* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05424507
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05223508
113CLOCK_20551151_ChIP-Seq_293T_Human1.05171524
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04752231
115* EZH2_27294783_Chip-Seq_NPCs_Mouse1.04531325
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01739834
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01386283
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01278455
119SOX9_26525672_Chip-Seq_HEART_Mouse1.00717195
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00670986
121IGF1R_20145208_ChIP-Seq_DFB_Human1.00333379
122SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00120918
123STAT1_20625510_ChIP-Seq_HELA_Human0.99251516
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98478170
125* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97647093
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.97609894
127* NFE2_27457419_Chip-Seq_LIVER_Mouse0.97126787
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95414658
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95384012
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94713432
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94009549
132CREB1_26743006_Chip-Seq_LNCaP_Human0.93835285
133AR_25329375_ChIP-Seq_VCAP_Human0.93460694
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.92285150
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.91890921
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90375135
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90375135
138GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.90203394
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89339103
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88322464
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88252080
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.87299861
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87147652
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86671116
145CTCF_21964334_Chip-Seq_Bcells_Human0.86649733
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.86336395
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85731819
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.85694697
149HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85222505
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85193164
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83792243
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83322403
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83195154
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82431240
155KDM2B_26808549_Chip-Seq_DND41_Human0.81389457
156EED_16625203_ChIP-ChIP_MESCs_Mouse0.81288908
157LXR_22292898_ChIP-Seq_THP-1_Human0.80968483
158EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80070553
159KDM2B_26808549_Chip-Seq_K562_Human0.79840666
160TP63_22573176_ChIP-Seq_HFKS_Human0.79339651
161KLF4_19829295_ChIP-Seq_ESCs_Human0.79225803
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.78749512
163STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.78573711
164OCT1_27270436_Chip-Seq_PROSTATE_Human0.78486901
165BCL6_27268052_Chip-Seq_Bcells_Human0.78402767
166TP53_18474530_ChIP-ChIP_U2OS_Human0.78311743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.04233540
2MP0000749_muscle_degeneration6.22258930
3MP0003646_muscle_fatigue6.08832058
4MP0000751_myopathy5.58035686
5MP0000747_muscle_weakness4.46250363
6* MP0002106_abnormal_muscle_physiology4.13695904
7MP0004036_abnormal_muscle_relaxation4.13470429
8* MP0000759_abnormal_skeletal_muscle3.72500769
9MP0002269_muscular_atrophy3.59644164
10MP0004130_abnormal_muscle_cell3.52403656
11MP0002837_dystrophic_cardiac_calcinosis3.52163510
12* MP0005369_muscle_phenotype3.44676874
13* MP0004087_abnormal_muscle_fiber3.19445960
14MP0005620_abnormal_muscle_contractility3.16513424
15MP0000750_abnormal_muscle_regeneration2.99699047
16MP0008438_abnormal_cutaneous_collagen2.91269945
17MP0004233_abnormal_muscle_weight2.73153858
18MP0000733_abnormal_muscle_development2.22549023
19MP0002332_abnormal_exercise_endurance2.18580718
20MP0004270_analgesia2.08641076
21MP0006036_abnormal_mitochondrial_physio1.83426418
22* MP0002108_abnormal_muscle_morphology1.72091442
23MP0001542_abnormal_bone_strength1.71467118
24MP0005330_cardiomyopathy1.70414226
25MP0003828_pulmonary_edema1.67747324
26MP0004185_abnormal_adipocyte_glucose1.63315515
27MP0005275_abnormal_skin_tensile1.59819925
28MP0002971_abnormal_brown_adipose1.57802959
29MP0003279_aneurysm1.54192977
30MP0010030_abnormal_orbit_morphology1.50551936
31MP0004084_abnormal_cardiac_muscle1.44526012
32MP0002972_abnormal_cardiac_muscle1.27374780
33MP0004215_abnormal_myocardial_fiber1.25602880
34MP0005666_abnormal_adipose_tissue1.21227351
35MP0000013_abnormal_adipose_tissue1.20362184
36MP0004272_abnormal_basement_membrane1.16559030
37MP0004484_altered_response_of1.11755190
38MP0005266_abnormal_metabolism1.07277677
39MP0005375_adipose_tissue_phenotype1.04275751
40MP0003221_abnormal_cardiomyocyte_apopto1.03933659
41MP0005171_absent_coat_pigmentation1.01508305
42MP0000467_abnormal_esophagus_morphology1.00255357
43MP0005360_urolithiasis0.99330180
44MP0001958_emphysema0.98988202
45MP0003705_abnormal_hypodermis_morpholog0.98504580
46MP0010630_abnormal_cardiac_muscle0.95896940
47MP0002796_impaired_skin_barrier0.95734332
48MP0001485_abnormal_pinna_reflex0.92363087
49MP0005623_abnormal_meninges_morphology0.91982748
50MP0000767_abnormal_smooth_muscle0.91743656
51MP0001299_abnormal_eye_distance/0.90006275
52MP0004883_abnormal_blood_vessel0.89929024
53MP0002102_abnormal_ear_morphology0.89908263
54MP0008789_abnormal_olfactory_epithelium0.88426731
55MP0000569_abnormal_digit_pigmentation0.87371545
56MP0003806_abnormal_nucleotide_metabolis0.87065536
57MP0000372_irregular_coat_pigmentation0.86575538
58MP0006035_abnormal_mitochondrial_morpho0.84633792
59MP0001544_abnormal_cardiovascular_syste0.81996867
60MP0005385_cardiovascular_system_phenoty0.81996867
61MP0003137_abnormal_impulse_conducting0.80410837
62MP0009384_cardiac_valve_regurgitation0.78310790
63MP0004134_abnormal_chest_morphology0.76939108
64MP0000003_abnormal_adipose_tissue0.75292284
65MP0003191_abnormal_cellular_cholesterol0.72354371
66MP0003385_abnormal_body_wall0.71334833
67* MP0002078_abnormal_glucose_homeostasis0.70818338
68MP0002254_reproductive_system_inflammat0.69718191
69MP0005595_abnormal_vascular_smooth0.69042524
70MP0001661_extended_life_span0.68062990
71MP0008961_abnormal_basal_metabolism0.67458257
72MP0002234_abnormal_pharynx_morphology0.67182624
73MP0003091_abnormal_cell_migration0.66501572
74MP0009250_abnormal_appendicular_skeleto0.63524247
75MP0002734_abnormal_mechanical_nocicepti0.63159024
76MP0002249_abnormal_larynx_morphology0.63132773
77MP0000762_abnormal_tongue_morphology0.62364958
78* MP0005334_abnormal_fat_pad0.59531419
79MP0002933_joint_inflammation0.59387481
80MP0000534_abnormal_ureter_morphology0.57793791
81MP0002168_other_aberrant_phenotype0.57572483
82MP0004147_increased_porphyrin_level0.57224002
83MP0000579_abnormal_nail_morphology0.54719227
84MP0008569_lethality_at_weaning0.54296119
85MP0002184_abnormal_innervation0.54238290
86MP0005023_abnormal_wound_healing0.53696988
87* MP0005452_abnormal_adipose_tissue0.53279169
88MP0003755_abnormal_palate_morphology0.53165190
89MP0003045_fibrosis0.52200355
90MP0004859_abnormal_synaptic_plasticity0.51952615
91MP0003656_abnormal_erythrocyte_physiolo0.51280962
92MP0004043_abnormal_pH_regulation0.51259943
93MP0004510_myositis0.51210372
94MP0000383_abnormal_hair_follicle0.50481852
95MP0010368_abnormal_lymphatic_system0.49199970
96MP0001486_abnormal_startle_reflex0.49156390
97MP0005388_respiratory_system_phenotype0.48597159
98MP0002133_abnormal_respiratory_system0.48597159
99MP0003935_abnormal_craniofacial_develop0.47889600
100MP0004142_abnormal_muscle_tone0.47580092
101MP0002233_abnormal_nose_morphology0.47550227
102MP0005503_abnormal_tendon_morphology0.47205319
103MP0001346_abnormal_lacrimal_gland0.47067900
104MP0003566_abnormal_cell_adhesion0.46335013
105MP0003195_calcinosis0.46167165
106MP0000685_abnormal_immune_system0.44727007
107MP0005670_abnormal_white_adipose0.44147939
108MP0000230_abnormal_systemic_arterial0.43416601
109MP0002113_abnormal_skeleton_development0.41160512
110MP0000163_abnormal_cartilage_morphology0.40848528
111MP0003948_abnormal_gas_homeostasis0.38759359
112MP0005535_abnormal_body_temperature0.38701899
113* MP0000266_abnormal_heart_morphology0.37765617
114MP0003950_abnormal_plasma_membrane0.37691208
115MP0002128_abnormal_blood_circulation0.36874994
116MP0008775_abnormal_heart_ventricle0.36494845
117MP0003136_yellow_coat_color0.36207625
118MP0002932_abnormal_joint_morphology0.35863747
119MP0002138_abnormal_hepatobiliary_system0.35804758
120MP0006138_congestive_heart_failure0.35625573
121MP0000343_altered_response_to0.35225518
122MP0001849_ear_inflammation0.34730611
123MP0009115_abnormal_fat_cell0.34578282
124MP0005501_abnormal_skin_physiology0.34334253
125MP0010678_abnormal_skin_adnexa0.33593514
126MP0005584_abnormal_enzyme/coenzyme_acti0.33158617
127MP0002066_abnormal_motor_capabilities/c0.32950364
128MP0005448_abnormal_energy_balance0.32915441
129MP0001502_abnormal_circadian_rhythm0.32247839
130MP0009672_abnormal_birth_weight0.31906928
131MP0001943_abnormal_respiration0.31196324
132MP0001348_abnormal_lacrimal_gland0.30158520
133MP0002127_abnormal_cardiovascular_syste0.29545124
134* MP0002896_abnormal_bone_mineralization0.28878808
135MP0002909_abnormal_adrenal_gland0.28184134
136MP0001243_abnormal_dermal_layer0.28121892
137MP0009780_abnormal_chondrocyte_physiolo0.27934956
138MP0005376_homeostasis/metabolism_phenot0.27846658
139MP0002114_abnormal_axial_skeleton0.27648332
140MP0005647_abnormal_sex_gland0.27543152
141MP0005645_abnormal_hypothalamus_physiol0.27192777
142MP0002970_abnormal_white_adipose0.27018742
143MP0002876_abnormal_thyroid_physiology0.26370939

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.52310188
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.24613753
3Popliteal pterygium (HP:0009756)8.71214456
4Exercise-induced myalgia (HP:0003738)8.70334413
5Nemaline bodies (HP:0003798)8.54278326
6Exercise-induced muscle cramps (HP:0003710)7.99052870
7Distal arthrogryposis (HP:0005684)7.54933449
8Type 2 muscle fiber atrophy (HP:0003554)7.29531488
9Type 1 muscle fiber predominance (HP:0003803)6.81424911
10Myopathic facies (HP:0002058)6.76326127
11Abnormality of placental membranes (HP:0011409)6.65225280
12Amniotic constriction ring (HP:0009775)6.65225280
13Muscle hypertrophy of the lower extremities (HP:0008968)6.59398365
14Muscle fiber atrophy (HP:0100295)6.49622421
15Round ear (HP:0100830)6.35359042
16Ulnar deviation of the wrist (HP:0003049)6.25628075
17Calf muscle hypertrophy (HP:0008981)5.79553871
18Difficulty running (HP:0009046)5.45169741
19Calcaneovalgus deformity (HP:0001848)5.44787376
20Myoglobinuria (HP:0002913)5.28290177
21Absent phalangeal crease (HP:0006109)5.18241610
22Muscle fiber splitting (HP:0003555)5.16558895
23Deformed tarsal bones (HP:0008119)4.90844309
24Muscle stiffness (HP:0003552)4.78225114
25Hyporeflexia of lower limbs (HP:0002600)4.59339182
26EMG: myopathic abnormalities (HP:0003458)4.45922869
27Rhabdomyolysis (HP:0003201)4.37030409
28Increased connective tissue (HP:0009025)4.34386830
29Abnormal finger flexion creases (HP:0006143)4.32428601
30Aplasia of the musculature (HP:0100854)4.29056389
31Myotonia (HP:0002486)4.11429989
32Easy fatigability (HP:0003388)4.04149890
33Pterygium (HP:0001059)3.99312855
34Abnormality of the calf musculature (HP:0001430)3.88051566
35Thin ribs (HP:0000883)3.80719238
36Abnormality of skeletal muscle fiber size (HP:0012084)3.63835500
37Rimmed vacuoles (HP:0003805)3.62260592
38Malignant hyperthermia (HP:0002047)3.61527562
39Shoulder girdle muscle weakness (HP:0003547)3.58309149
40Akinesia (HP:0002304)3.52677437
41Pelvic girdle muscle weakness (HP:0003749)3.47772271
42Neck muscle weakness (HP:0000467)3.39634924
43Abnormality of the musculature of the pelvis (HP:0001469)3.37132994
44Abnormality of the hip-girdle musculature (HP:0001445)3.37132994
45Difficulty climbing stairs (HP:0003551)3.33714786
46Increased variability in muscle fiber diameter (HP:0003557)3.32539019
47Abnormality of the left ventricular outflow tract (HP:0011103)3.31685005
48Subaortic stenosis (HP:0001682)3.31685005
49Abnormality of the calcaneus (HP:0008364)3.23006538
50Frequent falls (HP:0002359)3.06658551
51Areflexia of lower limbs (HP:0002522)3.00279517
52Depressed nasal tip (HP:0000437)2.93074826
53Hyperkalemia (HP:0002153)2.92962855
54Cystic hygroma (HP:0000476)2.92850597
55Palpebral edema (HP:0100540)2.90484606
56Abnormality of the neuromuscular junction (HP:0003398)2.76626110
57Fatigable weakness (HP:0003473)2.76626110
58Decreased muscle mass (HP:0003199)2.63523242
59Paralysis (HP:0003470)2.59488003
60Sudden death (HP:0001699)2.59107130
61Asymmetric septal hypertrophy (HP:0001670)2.53747711
62Slender build (HP:0001533)2.48775766
63Mask-like facies (HP:0000298)2.46340779
64EMG: neuropathic changes (HP:0003445)2.40958600
65Aortic aneurysm (HP:0004942)2.36823831
66Muscular dystrophy (HP:0003560)2.33971937
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.31117591
68Limb-girdle muscle weakness (HP:0003325)2.28837308
69Aortic dissection (HP:0002647)2.25867244
70Distal lower limb muscle weakness (HP:0009053)2.23602238
71Hypoplastic ischia (HP:0003175)2.22546404
72Arterial tortuosity (HP:0005116)2.18915166
73Abnormalities of placenta or umbilical cord (HP:0001194)2.17012939
74Metatarsus adductus (HP:0001840)2.15736679
75Ulnar deviation of finger (HP:0009465)2.15257311
76Bulbar palsy (HP:0001283)2.14929929
77Generalized muscle weakness (HP:0003324)2.14006166
78Mildly elevated creatine phosphokinase (HP:0008180)2.12961237
79Webbed neck (HP:0000465)2.08901514
80Abnormality of the shoulder girdle musculature (HP:0001435)2.03720997
81Bell-shaped thorax (HP:0001591)2.03532127
82Hip contracture (HP:0003273)2.03473496
83Hypoplastic heart (HP:0001961)2.02859586
84Proximal amyotrophy (HP:0007126)2.02822524
85Nonprogressive disorder (HP:0003680)2.02440136
86Vascular tortuosity (HP:0004948)2.00954938
87Poor suck (HP:0002033)1.99044999
88Lipoatrophy (HP:0100578)1.97327078
89Spinal rigidity (HP:0003306)1.96339793
90Abnormality of the ischium (HP:0003174)1.95650329
91Scapular winging (HP:0003691)1.94319381
92Achilles tendon contracture (HP:0001771)1.93072562
93Facial diplegia (HP:0001349)1.92901240
94Limb-girdle muscle atrophy (HP:0003797)1.92807993
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92172367
96Centrally nucleated skeletal muscle fibers (HP:0003687)1.90961054
97Oligomenorrhea (HP:0000876)1.86441498
98Distal lower limb amyotrophy (HP:0008944)1.84338663
99Gowers sign (HP:0003391)1.83450596
100Stridor (HP:0010307)1.82324417
101Fetal akinesia sequence (HP:0001989)1.79959182
102Ventricular tachycardia (HP:0004756)1.79245325
103Arthrogryposis multiplex congenita (HP:0002804)1.79105912
104Hyperglycemia (HP:0003074)1.78889461
105Trismus (HP:0000211)1.77992366
106Diminished movement (HP:0002374)1.77192579
107Weak cry (HP:0001612)1.76692749
108Abnormality of the Achilles tendon (HP:0005109)1.75430325
109Microglossia (HP:0000171)1.74149187
110Fibular aplasia (HP:0002990)1.71591319
111Protrusio acetabuli (HP:0003179)1.71018598
112Cholelithiasis (HP:0001081)1.70108535
113Limited hip movement (HP:0008800)1.70033114
114Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.69078749
115Hyperuricemia (HP:0002149)1.68346229
116Increased purine levels (HP:0004368)1.68346229
117Reduced subcutaneous adipose tissue (HP:0003758)1.67788186
118Tarsal synostosis (HP:0008368)1.65790182
119Waddling gait (HP:0002515)1.65092183
120Progressive muscle weakness (HP:0003323)1.65027821
121Rocker bottom foot (HP:0001838)1.62116405
122Gout (HP:0001997)1.59787146
123Abnormality of potassium homeostasis (HP:0011042)1.59228020
124Adducted thumb (HP:0001181)1.58897130
125Delayed gross motor development (HP:0002194)1.57675443
126Short palpebral fissure (HP:0012745)1.57492407
127Abnormal gallbladder morphology (HP:0012437)1.56310472
128Increased density of long bones (HP:0006392)1.50831550
129Synostosis involving bones of the feet (HP:0009140)1.50405972
130Synostosis involving bones of the lower limbs (HP:0009138)1.50405972
131Abnormality of the umbilical cord (HP:0010881)1.46113287
132Respiratory insufficiency due to muscle weakness (HP:0002747)1.46041522
133Symphalangism affecting the phalanges of the hand (HP:0009773)1.44222627
134Long clavicles (HP:0000890)1.43596208
135Spondylolisthesis (HP:0003302)1.43510726
136Left ventricular hypertrophy (HP:0001712)1.43431538
137Prolonged QT interval (HP:0001657)1.43400328
138Hypokalemia (HP:0002900)1.42326166
139Wrist flexion contracture (HP:0001239)1.39713362
140Lower limb amyotrophy (HP:0007210)1.39227402
141Insulin-resistant diabetes mellitus (HP:0000831)1.38020249
142Exercise intolerance (HP:0003546)1.37671382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.44672558
2PHKG16.00102509
3PHKG26.00102509
4TTN5.90681429
5NME14.63907634
6PIK3CG3.66101281
7MAP3K123.30385571
8BRD42.72151301
9NEK12.53146230
10CCNB12.40688135
11MAP2K32.35541957
12PINK12.30288234
13MAP3K72.08108165
14PDK41.80492362
15PDK31.80492362
16MAPKAPK51.72849472
17MAP2K41.72338228
18PIK3CA1.67589201
19ERBB31.60576477
20MAPK121.55166270
21MYLK1.52087718
22TRIB31.46532698
23MAP2K61.45965867
24BCKDK1.40254435
25DMPK1.36867498
26EIF2AK31.33756826
27CDK81.27486483
28NEK91.26703135
29TIE11.12144594
30MAPK151.11078865
31DYRK1B1.10811754
32MUSK1.08255015
33PDK21.06194593
34TGFBR21.06093348
35MELK1.02000000
36DYRK30.93327968
37FGFR10.91202210
38PRKAA20.90220828
39STK240.89546144
40PRKAA10.84800447
41TAOK10.83059671
42MAPKAPK30.81851384
43EIF2AK20.79367358
44LIMK10.77173437
45KSR20.71780927
46MAP3K30.71776332
47PLK20.70621916
48EIF2AK10.69282357
49DAPK30.64642403
50TAF10.64535925
51CAMK2B0.63469279
52CDK40.60769896
53NTRK20.59590310
54EPHB10.59235166
55CAMK2G0.59108966
56PDGFRA0.57244939
57ROCK20.56710439
58PAK40.56617350
59FGFR20.55530930
60PRKD30.53635336
61PAK60.52651780
62MAP3K60.52586701
63PAK20.51414788
64MAPK110.50774479
65TYRO30.50199841
66TAOK20.50105427
67CDK90.49927173
68LATS20.48625399
69ILK0.47741146
70SGK20.47210301
71SIK10.46337476
72KSR10.45920038
73NUAK10.44450712
74CHEK20.44210670
75TRPM70.44148959
76DAPK20.44082798
77VRK20.43852609
78LATS10.43660157
79PTK60.42586284
80WNK10.41891764
81PKN20.41180818
82MARK20.40405727
83RPS6KB10.38894606
84STK390.38876387
85AKT20.38682119
86ERBB40.37458707
87MARK10.36390853
88MAP3K100.36124250
89SGK10.35537761
90ABL10.35428256
91RIPK10.34968863
92MAP3K90.32794860
93ZAK0.32635101
94PTK20.32473066
95CAMK2A0.31027009
96MAP3K40.29853771
97DAPK10.29545213
98CASK0.29314789
99PKN10.29272548
100CSNK1G10.28230767
101CSNK1G20.27575902
102RPS6KA30.27328823
103PRKACB0.26581912
104GRK50.26376179
105NLK0.26276019
106MAP2K10.24448637
107PRKACA0.24321139
108SCYL20.23929350
109MST1R0.23618454
110PRKG10.23000238
111WNK40.22973157
112EEF2K0.22682501
113GRK70.22502514
114LRRK20.22340050
115SGK4940.21971966
116SGK2230.21971966
117MAP3K110.21742573
118FER0.21209017
119EGFR0.21133569
120ABL20.20293615
121MAP3K50.19939206
122CDK150.18196463
123MAP3K10.18178005
124INSRR0.18103521
125MOS0.17381610
126CDK11A0.17314202
127ERN10.16596380
128MAPK40.16223456
129PDPK10.13882926
130GSK3A0.13652861
131PRKD10.13574881
132ROCK10.13240922
133MAPK130.12917177
134RPS6KA10.12827031
135PAK30.12737786
136RPS6KA20.11260782
137STK110.10028163
138DYRK1A0.09470950
139CAMK1G0.09174560
140CAMK2D0.09165077
141PRKACG0.08880948
142PDK10.08739140
143MAPK70.08000991
144RAF10.07989136
145TNK20.06541584
146MAP3K20.06266188
147MINK10.05398200
148DDR20.05388717
149JAK20.05260736
150MAPK80.04332281
151SGK30.04252575
152MAPK100.03968875
153EPHB20.03041829
154PRKCH0.02767324
155PRKCG0.02552078

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.81007204
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.70539278
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.65528224
4Cardiac muscle contraction_Homo sapiens_hsa042603.22775465
5Dilated cardiomyopathy_Homo sapiens_hsa054143.12184942
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.78615887
7Starch and sucrose metabolism_Homo sapiens_hsa005002.63986998
8Glucagon signaling pathway_Homo sapiens_hsa049222.45279150
9Oxytocin signaling pathway_Homo sapiens_hsa049212.36727547
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.35090020
11Insulin signaling pathway_Homo sapiens_hsa049102.29600370
12Circadian rhythm_Homo sapiens_hsa047102.25524898
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.05194591
14Insulin resistance_Homo sapiens_hsa049311.95439757
15Propanoate metabolism_Homo sapiens_hsa006401.90831410
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79439992
17Calcium signaling pathway_Homo sapiens_hsa040201.78213447
18Carbon metabolism_Homo sapiens_hsa012001.77871465
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77272516
20AMPK signaling pathway_Homo sapiens_hsa041521.68665378
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.60344902
22Parkinsons disease_Homo sapiens_hsa050121.52858425
23Alzheimers disease_Homo sapiens_hsa050101.50508956
24Pyruvate metabolism_Homo sapiens_hsa006201.45705517
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43682992
26Galactose metabolism_Homo sapiens_hsa000521.38255102
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37512045
28Oxidative phosphorylation_Homo sapiens_hsa001901.36843005
29Tight junction_Homo sapiens_hsa045301.29666690
30ECM-receptor interaction_Homo sapiens_hsa045121.28658170
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26618125
32Biosynthesis of amino acids_Homo sapiens_hsa012301.26394294
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.20853057
34Melanoma_Homo sapiens_hsa052181.20239321
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19179996
36Wnt signaling pathway_Homo sapiens_hsa043101.18341451
37Gastric acid secretion_Homo sapiens_hsa049711.17779601
38TGF-beta signaling pathway_Homo sapiens_hsa043501.17118058
39Glioma_Homo sapiens_hsa052141.16707389
40Viral myocarditis_Homo sapiens_hsa054161.10944353
41Fructose and mannose metabolism_Homo sapiens_hsa000511.10919213
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08932368
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06590437
44Fatty acid degradation_Homo sapiens_hsa000711.05498697
45GnRH signaling pathway_Homo sapiens_hsa049121.05026207
46Arginine and proline metabolism_Homo sapiens_hsa003301.00810480
47Hippo signaling pathway_Homo sapiens_hsa043901.00004933
48Renin secretion_Homo sapiens_hsa049240.96150595
49Arginine biosynthesis_Homo sapiens_hsa002200.95796073
50Protein digestion and absorption_Homo sapiens_hsa049740.94556686
51Colorectal cancer_Homo sapiens_hsa052100.93787238
52Hedgehog signaling pathway_Homo sapiens_hsa043400.92405526
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91709207
54FoxO signaling pathway_Homo sapiens_hsa040680.90088994
55Olfactory transduction_Homo sapiens_hsa047400.89832806
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89250865
57Fatty acid metabolism_Homo sapiens_hsa012120.88705441
58Focal adhesion_Homo sapiens_hsa045100.88655877
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.85816775
60Insulin secretion_Homo sapiens_hsa049110.84964310
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84036873
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82618328
63VEGF signaling pathway_Homo sapiens_hsa043700.78994859
64MicroRNAs in cancer_Homo sapiens_hsa052060.77571762
65Pentose phosphate pathway_Homo sapiens_hsa000300.77477940
66Linoleic acid metabolism_Homo sapiens_hsa005910.77475695
67Fatty acid biosynthesis_Homo sapiens_hsa000610.77216317
68Axon guidance_Homo sapiens_hsa043600.74987754
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74626758
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73055368
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.72134153
72Endocytosis_Homo sapiens_hsa041440.70731747
73cAMP signaling pathway_Homo sapiens_hsa040240.70717207
74MAPK signaling pathway_Homo sapiens_hsa040100.70601517
75mTOR signaling pathway_Homo sapiens_hsa041500.67672228
76Basal cell carcinoma_Homo sapiens_hsa052170.67348298
77Pancreatic cancer_Homo sapiens_hsa052120.66354180
78Circadian entrainment_Homo sapiens_hsa047130.65969087
79Lysine degradation_Homo sapiens_hsa003100.63084936
80Huntingtons disease_Homo sapiens_hsa050160.60143088
81Long-term depression_Homo sapiens_hsa047300.59400294
82Type II diabetes mellitus_Homo sapiens_hsa049300.57650447
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56901076
84p53 signaling pathway_Homo sapiens_hsa041150.56581535
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56159522
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55551891
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54168714
88Chronic myeloid leukemia_Homo sapiens_hsa052200.53583874
89Cholinergic synapse_Homo sapiens_hsa047250.52420850
90Estrogen signaling pathway_Homo sapiens_hsa049150.51901615
91Nitrogen metabolism_Homo sapiens_hsa009100.51632051
92PPAR signaling pathway_Homo sapiens_hsa033200.49162186
93HIF-1 signaling pathway_Homo sapiens_hsa040660.45981652
94Oocyte meiosis_Homo sapiens_hsa041140.45669667
95Ras signaling pathway_Homo sapiens_hsa040140.45259251
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45253698
97Long-term potentiation_Homo sapiens_hsa047200.44936490
98Thyroid hormone synthesis_Homo sapiens_hsa049180.44526308
99Butanoate metabolism_Homo sapiens_hsa006500.43028559
100Endometrial cancer_Homo sapiens_hsa052130.42829477
101Rap1 signaling pathway_Homo sapiens_hsa040150.41749023
102Prostate cancer_Homo sapiens_hsa052150.41347293
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.41277162
104Small cell lung cancer_Homo sapiens_hsa052220.40727519
105Selenocompound metabolism_Homo sapiens_hsa004500.40458056
106Amoebiasis_Homo sapiens_hsa051460.39876729
107GABAergic synapse_Homo sapiens_hsa047270.39690287
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39647938
109Folate biosynthesis_Homo sapiens_hsa007900.38485366
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38207939
111Dorso-ventral axis formation_Homo sapiens_hsa043200.37068026
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37032635
113Regulation of autophagy_Homo sapiens_hsa041400.35539426
114Pancreatic secretion_Homo sapiens_hsa049720.34908795
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34880066
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34355558
117Phenylalanine metabolism_Homo sapiens_hsa003600.34048260
118Adherens junction_Homo sapiens_hsa045200.33873395
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.33483033
120Platelet activation_Homo sapiens_hsa046110.33435657
121Fatty acid elongation_Homo sapiens_hsa000620.32138210
122Salivary secretion_Homo sapiens_hsa049700.32078438
123beta-Alanine metabolism_Homo sapiens_hsa004100.31296691
124Renal cell carcinoma_Homo sapiens_hsa052110.30333397
125Sulfur metabolism_Homo sapiens_hsa009200.29159107
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29125624
127Gap junction_Homo sapiens_hsa045400.28511929
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28137606
129Fat digestion and absorption_Homo sapiens_hsa049750.27724544
130Phototransduction_Homo sapiens_hsa047440.27658393
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.26678324
132Amphetamine addiction_Homo sapiens_hsa050310.26298006
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25380500
134Dopaminergic synapse_Homo sapiens_hsa047280.25317973
135Proteoglycans in cancer_Homo sapiens_hsa052050.23524037
136Prolactin signaling pathway_Homo sapiens_hsa049170.23346937
137ABC transporters_Homo sapiens_hsa020100.22544826
138Histidine metabolism_Homo sapiens_hsa003400.22506799
139Melanogenesis_Homo sapiens_hsa049160.21092850

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