MSTO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.56155351
2protein localization to kinetochore (GO:0034501)6.08098543
3regulation of nuclear cell cycle DNA replication (GO:0033262)5.98993888
4maintenance of protein location in nucleus (GO:0051457)5.84949996
5regulation of mammary gland epithelial cell proliferation (GO:0033599)5.84392458
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.71792322
7regulation of telomere maintenance via telomerase (GO:0032210)5.71107206
8negative regulation of epidermis development (GO:0045683)5.60388903
9somite rostral/caudal axis specification (GO:0032525)5.54570609
10histone H4-K12 acetylation (GO:0043983)5.31501387
11negative regulation of telomerase activity (GO:0051974)5.25889429
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.25372152
13COPI coating of Golgi vesicle (GO:0048205)5.16910946
14Golgi transport vesicle coating (GO:0048200)5.16910946
15histone H4-K5 acetylation (GO:0043981)5.14361159
16histone H4-K8 acetylation (GO:0043982)5.14361159
17regulation of response to osmotic stress (GO:0047484)5.12661672
18rRNA transcription (GO:0009303)5.10085365
19negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.01319341
20mitotic sister chromatid segregation (GO:0000070)4.94557917
21rRNA methylation (GO:0031167)4.74662395
22DNA replication-dependent nucleosome organization (GO:0034723)4.74078523
23DNA replication-dependent nucleosome assembly (GO:0006335)4.74078523
24DNA replication checkpoint (GO:0000076)4.68914542
25protein localization to chromosome, centromeric region (GO:0071459)4.67563071
26regulation of MHC class I biosynthetic process (GO:0045343)4.67251415
27rRNA modification (GO:0000154)4.60840838
28regulation of cilium movement (GO:0003352)4.57470443
29negative regulation of epidermal cell differentiation (GO:0045605)4.54705989
30heterochromatin organization (GO:0070828)4.52619738
31negative regulation of telomere maintenance (GO:0032205)4.48431191
32positive regulation of DNA-dependent DNA replication (GO:2000105)4.47740142
33regulation of translational fidelity (GO:0006450)4.46411043
34muscle organ morphogenesis (GO:0048644)4.39794259
35peptidyl-arginine omega-N-methylation (GO:0035247)4.38331630
36nuclear pore complex assembly (GO:0051292)4.33324251
37cullin deneddylation (GO:0010388)4.26835001
38notochord development (GO:0030903)4.25288882
39regulation of translation in response to stress (GO:0043555)4.11620616
40sister chromatid segregation (GO:0000819)4.03114342
41tRNA aminoacylation for protein translation (GO:0006418)4.00510164
42regulation of apoptotic process involved in morphogenesis (GO:1902337)3.99179451
43nuclear pore organization (GO:0006999)3.93977773
44cytidine deamination (GO:0009972)3.93697393
45cytidine metabolic process (GO:0046087)3.93697393
46cytidine catabolic process (GO:0006216)3.93697393
47chromatin assembly (GO:0031497)3.93645485
48tRNA aminoacylation (GO:0043039)3.89873003
49amino acid activation (GO:0043038)3.89873003
50tRNA methylation (GO:0030488)3.88517191
51DNA strand elongation involved in DNA replication (GO:0006271)3.86118313
52nucleoside transmembrane transport (GO:1901642)3.85318604
53quinone metabolic process (GO:1901661)3.83242225
54ribosome biogenesis (GO:0042254)3.82806821
55protein deneddylation (GO:0000338)3.82350147
56DNA strand elongation (GO:0022616)3.79383603
57formation of translation preinitiation complex (GO:0001731)3.78806837
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.78752890
59protein retention in ER lumen (GO:0006621)3.73346146
60establishment of viral latency (GO:0019043)3.70646915
61primitive streak formation (GO:0090009)3.70481868
62histone H4-K16 acetylation (GO:0043984)3.69937239
63ribosome assembly (GO:0042255)3.69645698
64cell fate commitment involved in formation of primary germ layer (GO:0060795)3.69282900
65spliceosomal tri-snRNP complex assembly (GO:0000244)3.66921735
66DNA damage response, detection of DNA damage (GO:0042769)3.64153303
67proline biosynthetic process (GO:0006561)3.63857232
68pseudouridine synthesis (GO:0001522)3.61656699
69branching involved in mammary gland duct morphogenesis (GO:0060444)3.60505850
70interferon-gamma production (GO:0032609)3.60091951
71regulation of telomere maintenance (GO:0032204)3.53375738
72regulation of telomerase activity (GO:0051972)3.48820599
73peptidyl-arginine N-methylation (GO:0035246)3.47952806
74peptidyl-arginine methylation (GO:0018216)3.47952806
75regulation of gene silencing by miRNA (GO:0060964)3.44697480
76regulation of gene silencing by RNA (GO:0060966)3.44697480
77regulation of posttranscriptional gene silencing (GO:0060147)3.44697480
78phenol-containing compound catabolic process (GO:0019336)3.43771996
79regulation of mitochondrial translation (GO:0070129)3.40307083
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.39920373
81transcription from mitochondrial promoter (GO:0006390)3.36026695
82IMP biosynthetic process (GO:0006188)3.35794974
83DNA replication initiation (GO:0006270)3.35578543
84DNA unwinding involved in DNA replication (GO:0006268)3.34829692
85maturation of 5.8S rRNA (GO:0000460)3.34595311
86L-serine metabolic process (GO:0006563)3.34181760
87telomere maintenance via semi-conservative replication (GO:0032201)3.34138778
88response to dietary excess (GO:0002021)3.33446189
89GDP-mannose metabolic process (GO:0019673)3.32549583
90retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32232578
91rRNA processing (GO:0006364)3.32050649
92pore complex assembly (GO:0046931)3.31537332
93DNA duplex unwinding (GO:0032508)3.31107375
94spliceosomal snRNP assembly (GO:0000387)3.27850044
95ribosomal small subunit biogenesis (GO:0042274)3.27631277
96DNA geometric change (GO:0032392)3.27120969
97chromosome condensation (GO:0030261)3.26875651
98intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.26126040
99ncRNA 3-end processing (GO:0043628)3.25556401
100mitotic nuclear envelope disassembly (GO:0007077)3.20114385
101establishment of integrated proviral latency (GO:0075713)3.19233624
102pre-miRNA processing (GO:0031054)3.14040273
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13216554
104ribonucleoprotein complex biogenesis (GO:0022613)3.13035716
105hormone catabolic process (GO:0042447)3.12972522
106regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.12466219
107cardiovascular system development (GO:0072358)3.12355181
108maintenance of protein localization in organelle (GO:0072595)3.11057275
109tRNA modification (GO:0006400)3.10850921
110ribosomal large subunit biogenesis (GO:0042273)3.10355067
111rRNA metabolic process (GO:0016072)3.09996076
112microtubule severing (GO:0051013)3.08352499
113mRNA stabilization (GO:0048255)3.06828293
114RNA stabilization (GO:0043489)3.06828293
115regulation of double-strand break repair (GO:2000779)3.05708708
116protein polyglutamylation (GO:0018095)3.04670379
117binding of sperm to zona pellucida (GO:0007339)3.04528948
118mitochondrial DNA replication (GO:0006264)3.04496079
119histone arginine methylation (GO:0034969)3.03805874
120nuclear envelope disassembly (GO:0051081)3.02836880
121membrane disassembly (GO:0030397)3.02836880
122RNA methylation (GO:0001510)3.02296616
123folic acid metabolic process (GO:0046655)2.99543435
124protein maturation by protein folding (GO:0022417)2.99240077
125metallo-sulfur cluster assembly (GO:0031163)2.99235145
126iron-sulfur cluster assembly (GO:0016226)2.99235145
127transcription elongation from RNA polymerase III promoter (GO:0006385)2.98753329
128termination of RNA polymerase III transcription (GO:0006386)2.98753329
129bone trabecula formation (GO:0060346)2.97599007
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96180152
131maturation of SSU-rRNA (GO:0030490)2.95869420
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94054594
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93587425
134negative regulation of ligase activity (GO:0051352)2.93587425
135nucleobase biosynthetic process (GO:0046112)2.91768633
136coenzyme catabolic process (GO:0009109)2.91443156
137mitochondrial RNA metabolic process (GO:0000959)2.91346067
138regulation of DNA-dependent DNA replication (GO:0090329)2.91284064
139mitotic chromosome condensation (GO:0007076)2.90751491
140anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90750179
141DNA conformation change (GO:0071103)2.90749316
142DNA packaging (GO:0006323)2.90359335
143cellular component biogenesis (GO:0044085)2.89434527
144regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.89257750
145nucleoside transport (GO:0015858)2.89015383
146negative regulation of mRNA processing (GO:0050686)2.87802002
147DNA topological change (GO:0006265)2.87798849
148positive regulation of protein deacetylation (GO:0090312)2.86567675
149base-excision repair (GO:0006284)2.86148026
150mitotic nuclear envelope reassembly (GO:0007084)2.86037667
151nuclear envelope reassembly (GO:0031468)2.86037667
152ncRNA processing (GO:0034470)2.84996416
153pyrimidine ribonucleoside catabolic process (GO:0046133)2.84024924
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82951599
155trophectodermal cell differentiation (GO:0001829)2.82445698
156retinoic acid receptor signaling pathway (GO:0048384)2.82327523
157tRNA metabolic process (GO:0006399)2.81726424
158ribosomal small subunit assembly (GO:0000028)2.81463531
159negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.81393158
160regulation of translational elongation (GO:0006448)2.81139187
161nuclear envelope organization (GO:0006998)2.80453121
162regulation of double-strand break repair via homologous recombination (GO:0010569)2.80137601
163peptidyl-histidine modification (GO:0018202)2.79678853
164apoptotic DNA fragmentation (GO:0006309)2.79002388
165spindle assembly (GO:0051225)2.78818780
166negative regulation of gene silencing (GO:0060969)2.77716601
167IMP metabolic process (GO:0046040)2.73256854
168base-excision repair, AP site formation (GO:0006285)2.73070619
169dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.72832669
170ncRNA metabolic process (GO:0034660)2.71981108
171mitochondrial fusion (GO:0008053)2.71928517
172nucleotide-sugar biosynthetic process (GO:0009226)2.71763846
173protein targeting to mitochondrion (GO:0006626)2.70271580
174polyketide metabolic process (GO:0030638)10.2166287
175doxorubicin metabolic process (GO:0044598)10.2166287
176daunorubicin metabolic process (GO:0044597)10.2166287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.74893541
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.74893541
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.74893541
4E2F7_22180533_ChIP-Seq_HELA_Human5.74572954
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.37399554
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.36825067
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.18316544
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.03515380
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91103957
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73951067
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.71774674
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.67638652
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.50672744
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.28023341
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26563302
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.25784064
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.25050990
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21742801
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16960705
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.15936168
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14907429
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13974241
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09490743
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08940064
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06981149
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.02515820
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02280870
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99561254
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98409961
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97110156
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94751312
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93736153
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.92657688
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91547051
35IRF1_19129219_ChIP-ChIP_H3396_Human1.86933896
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86760576
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84701105
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80551744
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.79881778
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79433524
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77978440
42VDR_21846776_ChIP-Seq_THP-1_Human1.77368147
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.74733707
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73059061
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.66844864
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65858703
47NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64938797
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60887731
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60113351
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59057957
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57111718
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56177484
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52986270
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50521557
55POU5F1_16518401_ChIP-PET_MESCs_Mouse1.49705583
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.48360816
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46796653
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.45826882
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.44458955
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44345166
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42423455
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42284342
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40585079
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38039197
65TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37958305
66POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37332768
67* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36888086
68NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36863674
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34009491
70LXR_22292898_ChIP-Seq_THP-1_Human1.33783163
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.32391400
72P68_20966046_ChIP-Seq_HELA_Human1.32334164
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31243495
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31128145
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.29859466
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.29548550
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28312873
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27288531
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.27200802
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26215553
81FOXP3_21729870_ChIP-Seq_TREG_Human1.25748873
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25428087
83* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24975146
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.24481058
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21239472
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21106525
87XRN2_22483619_ChIP-Seq_HELA_Human1.20513645
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19854973
89MYC_22102868_ChIP-Seq_BL_Human1.19735752
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19412526
91SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19379970
92E2F1_17053090_ChIP-ChIP_MCF-7_Human1.18697558
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18376423
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.17735227
95ZNF263_19887448_ChIP-Seq_K562_Human1.16969569
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14163181
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13052163
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.12700098
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12625606
100* MAF_26560356_Chip-Seq_TH2_Human1.12448143
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11873427
102RACK7_27058665_Chip-Seq_MCF-7_Human1.11619974
103HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11498588
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11349537
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09963035
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.09081187
107TFEB_21752829_ChIP-Seq_HELA_Human1.07857623
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07369930
109* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07178016
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.06978691
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04961379
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04582991
113TTF2_22483619_ChIP-Seq_HELA_Human1.04525738
114NANOG_21062744_ChIP-ChIP_HESCs_Human1.02896512
115PHF8_20622854_ChIP-Seq_HELA_Human1.02458675
116BCL6_27268052_Chip-Seq_Bcells_Human1.00260430
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98588957
118NANOG_16518401_ChIP-PET_MESCs_Mouse0.98492845
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98330025
120* RARB_24833708_ChIP-Seq_LIVER_Mouse0.98288757
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97364545
122GABP_19822575_ChIP-Seq_HepG2_Human0.96440381
123CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96280257
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95532380
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95489233
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95114363
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93994204
128BCOR_27268052_Chip-Seq_Bcells_Human0.93976564
129VDR_23849224_ChIP-Seq_CD4+_Human0.93425702
130SMC4_20622854_ChIP-Seq_HELA_Human0.93173792
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92927470
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92170474
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91690986
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89839512
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.86549527
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85138947
137TP53_22127205_ChIP-Seq_IMR90_Human0.83295475
138* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82970162
139KDM5A_27292631_Chip-Seq_BREAST_Human0.82909747
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82390293
141AR_21909140_ChIP-Seq_LNCAP_Human0.79792620
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79772544
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.79305282
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.78443205
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.78332375
146CIITA_25753668_ChIP-Seq_RAJI_Human0.77202673
147DCP1A_22483619_ChIP-Seq_HELA_Human0.77039327
148NCOR1_26117541_ChIP-Seq_K562_Human0.76277982
149* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75525158
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73547535
151* KAP1_27257070_Chip-Seq_ESCs_Mouse0.72748849
152* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72074211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.56642537
2MP0003011_delayed_dark_adaptation4.26393703
3MP0002254_reproductive_system_inflammat3.78134001
4MP0008057_abnormal_DNA_replication3.64498508
5MP0004264_abnormal_extraembryonic_tissu3.55748284
6MP0003890_abnormal_embryonic-extraembry3.31574238
7MP0004957_abnormal_blastocyst_morpholog3.27216182
8MP0005075_abnormal_melanosome_morpholog3.20396722
9MP0005394_taste/olfaction_phenotype2.99214733
10MP0005499_abnormal_olfactory_system2.99214733
11MP0003122_maternal_imprinting2.86831270
12MP0003121_genomic_imprinting2.49531644
13MP0004858_abnormal_nervous_system2.43411026
14MP0003806_abnormal_nucleotide_metabolis2.30320644
15MP0008260_abnormal_autophagy2.24717297
16MP0002332_abnormal_exercise_endurance2.22852213
17MP0006035_abnormal_mitochondrial_morpho2.16219135
18MP0005257_abnormal_intraocular_pressure2.14809245
19MP0002653_abnormal_ependyma_morphology2.13459454
20MP0003077_abnormal_cell_cycle2.05142626
21MP0010352_gastrointestinal_tract_polyps2.02158507
22MP0000678_abnormal_parathyroid_gland2.01515256
23MP0003111_abnormal_nucleus_morphology1.99573145
24MP0010030_abnormal_orbit_morphology1.93978224
25MP0005380_embryogenesis_phenotype1.88692316
26MP0001672_abnormal_embryogenesis/_devel1.88692316
27MP0010094_abnormal_chromosome_stability1.84934650
28MP0003123_paternal_imprinting1.81521265
29MP0003938_abnormal_ear_development1.80696109
30MP0004233_abnormal_muscle_weight1.75923821
31MP0002088_abnormal_embryonic_growth/wei1.71381835
32MP0003984_embryonic_growth_retardation1.71222770
33MP0002277_abnormal_respiratory_mucosa1.67428849
34MP0001293_anophthalmia1.67350538
35MP0000350_abnormal_cell_proliferation1.66746150
36MP0004133_heterotaxia1.63864626
37MP0002127_abnormal_cardiovascular_syste1.59399670
38MP0005171_absent_coat_pigmentation1.59127787
39MP0002396_abnormal_hematopoietic_system1.57667010
40MP0003693_abnormal_embryo_hatching1.57605413
41MP0005501_abnormal_skin_physiology1.55062960
42MP0005083_abnormal_biliary_tract1.53343528
43MP0000049_abnormal_middle_ear1.53305860
44MP0001661_extended_life_span1.50835403
45MP0000751_myopathy1.48743139
46MP0003705_abnormal_hypodermis_morpholog1.48716917
47MP0008932_abnormal_embryonic_tissue1.48499277
48MP0005451_abnormal_body_composition1.46727454
49MP0005670_abnormal_white_adipose1.45828530
50MP0008007_abnormal_cellular_replicative1.43249677
51MP0008789_abnormal_olfactory_epithelium1.41866027
52MP0002085_abnormal_embryonic_tissue1.39722952
53MP0006036_abnormal_mitochondrial_physio1.37129926
54MP0000003_abnormal_adipose_tissue1.36443964
55MP0002932_abnormal_joint_morphology1.33622523
56MP0002086_abnormal_extraembryonic_tissu1.30466849
57MP0003315_abnormal_perineum_morphology1.29897644
58MP0002092_abnormal_eye_morphology1.27726625
59MP0000762_abnormal_tongue_morphology1.26508947
60MP0008058_abnormal_DNA_repair1.24579896
61MP0003718_maternal_effect1.24033875
62MP0002084_abnormal_developmental_patter1.22778407
63MP0003786_premature_aging1.21535955
64MP0003119_abnormal_digestive_system1.21268787
65MP0000490_abnormal_crypts_of1.18983953
66MP0002233_abnormal_nose_morphology1.18345574
67MP0001849_ear_inflammation1.17727777
68MP0001730_embryonic_growth_arrest1.16602052
69MP0002132_abnormal_respiratory_system1.14897555
70MP0001929_abnormal_gametogenesis1.14521587
71MP0003186_abnormal_redox_activity1.14374411
72MP0009672_abnormal_birth_weight1.13798825
73MP0005266_abnormal_metabolism1.12738399
74MP0000313_abnormal_cell_death1.11956060
75MP0002114_abnormal_axial_skeleton1.11781721
76MP0010307_abnormal_tumor_latency1.11750636
77MP0008961_abnormal_basal_metabolism1.11548851
78MP0001529_abnormal_vocalization1.09349311
79MP0004381_abnormal_hair_follicle1.06550486
80MP0005058_abnormal_lysosome_morphology1.06253260
81MP0000432_abnormal_head_morphology1.05324700
82MP0001697_abnormal_embryo_size1.04010211
83MP0004197_abnormal_fetal_growth/weight/1.02980744
84MP0003183_abnormal_peptide_metabolism1.02803432
85MP0000428_abnormal_craniofacial_morphol1.01766543
86MP0003755_abnormal_palate_morphology1.00974958
87MP0003787_abnormal_imprinting1.00604192
88MP0003698_abnormal_male_reproductive0.99949355
89MP0001764_abnormal_homeostasis0.98940054
90MP0002796_impaired_skin_barrier0.98411482
91MP0009278_abnormal_bone_marrow0.96628896
92MP0002751_abnormal_autonomic_nervous0.96548554
93MP0006082_CNS_inflammation0.96528044
94MP0002080_prenatal_lethality0.95584211
95MP0009333_abnormal_splenocyte_physiolog0.95339592
96MP0003935_abnormal_craniofacial_develop0.94637241
97MP0005621_abnormal_cell_physiology0.94496962
98MP0002249_abnormal_larynx_morphology0.94454996
99MP0005623_abnormal_meninges_morphology0.92797840
100MP0001348_abnormal_lacrimal_gland0.92572980
101MP0003385_abnormal_body_wall0.92076081
102MP0004185_abnormal_adipocyte_glucose0.90636563
103MP0002060_abnormal_skin_morphology0.89745499
104MP0002210_abnormal_sex_determination0.89221330
105MP0001346_abnormal_lacrimal_gland0.88464275
106MP0005248_abnormal_Harderian_gland0.88338218
107MP0005410_abnormal_fertilization0.88063177
108MP0003453_abnormal_keratinocyte_physiol0.87342604
109MP0008770_decreased_survivor_rate0.87217023
110MP0003136_yellow_coat_color0.86930192
111MP0002161_abnormal_fertility/fecundity0.85454180
112MP0008995_early_reproductive_senescence0.85048906
113MP0005391_vision/eye_phenotype0.84029351
114MP0005508_abnormal_skeleton_morphology0.82724510
115MP0001286_abnormal_eye_development0.82132299
116MP0002116_abnormal_craniofacial_bone0.79416850
117MP0002970_abnormal_white_adipose0.77676129
118MP0003283_abnormal_digestive_organ0.76511015
119MP0003937_abnormal_limbs/digits/tail_de0.76037431
120MP0000358_abnormal_cell_content/0.75592291
121MP0005397_hematopoietic_system_phenotyp0.75572834
122MP0001545_abnormal_hematopoietic_system0.75572834
123MP0002925_abnormal_cardiovascular_devel0.74949593
124MP0005375_adipose_tissue_phenotype0.74685646
125MP0005076_abnormal_cell_differentiation0.74043801
126MP0003115_abnormal_respiratory_system0.73926836
127MP0003137_abnormal_impulse_conducting0.71994230
128MP0000750_abnormal_muscle_regeneration0.70664603
129MP0001145_abnormal_male_reproductive0.70478801
130MP0004808_abnormal_hematopoietic_stem0.69567152
131MP0002160_abnormal_reproductive_system0.69302178
132MP0004782_abnormal_surfactant_physiolog0.69044024
133MP0002697_abnormal_eye_size0.68520637
134MP0001216_abnormal_epidermal_layer0.68320034
135MP0000749_muscle_degeneration0.67998537
136MP0002111_abnormal_tail_morphology0.66377315
137MP0009931_abnormal_skin_appearance0.65345614
138MP0002098_abnormal_vibrissa_morphology0.65017565
139MP0005023_abnormal_wound_healing0.64263532
140MP0002019_abnormal_tumor_incidence0.63710547
141MP0005666_abnormal_adipose_tissue0.63358850
142MP0009703_decreased_birth_body0.62833712
143MP0003221_abnormal_cardiomyocyte_apopto0.62353552
144MP0002081_perinatal_lethality0.61958435
145MP0009250_abnormal_appendicular_skeleto0.61472836
146MP0005384_cellular_phenotype0.60803946
147MP0000858_altered_metastatic_potential0.59782536
148MP0003861_abnormal_nervous_system0.59548926
149MP0003566_abnormal_cell_adhesion0.59236201
150MP0001853_heart_inflammation0.58377201
151MP0003942_abnormal_urinary_system0.58293954

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.02574127
2Hypochromic microcytic anemia (HP:0004840)5.34734557
3Hepatoblastoma (HP:0002884)5.04534650
4Multiple enchondromatosis (HP:0005701)4.84394755
5Rib fusion (HP:0000902)4.56878162
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.29224077
7Ependymoma (HP:0002888)4.25477109
8Abnormality of the lower motor neuron (HP:0002366)4.17140153
9Nephroblastoma (Wilms tumor) (HP:0002667)3.96977847
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.84928471
11Abnormal protein N-linked glycosylation (HP:0012347)3.84928471
12Abnormal protein glycosylation (HP:0012346)3.84928471
13Abnormal glycosylation (HP:0012345)3.84928471
14Chromsome breakage (HP:0040012)3.73544183
15Embryonal renal neoplasm (HP:0011794)3.70278534
16Neoplasm of striated muscle (HP:0009728)3.70189231
17Rhabdomyosarcoma (HP:0002859)3.68471841
18Poikiloderma (HP:0001029)3.44822854
19Cerebral hypomyelination (HP:0006808)3.39947174
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.35506203
21Hypoplasia of the fovea (HP:0007750)3.35506203
22Partial duplication of thumb phalanx (HP:0009944)3.34033090
23Abnormality of glycolysis (HP:0004366)3.32038794
24Testicular atrophy (HP:0000029)3.31087953
25Rectal fistula (HP:0100590)3.27233182
26Rectovaginal fistula (HP:0000143)3.27233182
27Abnormal lung lobation (HP:0002101)3.23057849
28Squamous cell carcinoma (HP:0002860)3.22954106
29Fused cervical vertebrae (HP:0002949)3.22855900
30Trismus (HP:0000211)3.14868376
31Birth length less than 3rd percentile (HP:0003561)3.02199854
32Supernumerary spleens (HP:0009799)2.99096929
33Aplasia/hypoplasia of the humerus (HP:0006507)2.98004556
34Abnormality of the astrocytes (HP:0100707)2.96718814
35Astrocytoma (HP:0009592)2.96718814
36Ragged-red muscle fibers (HP:0003200)2.93140076
37Partial duplication of the phalanx of hand (HP:0009999)2.93121757
38Increased serum pyruvate (HP:0003542)2.91153802
39Breast hypoplasia (HP:0003187)2.90730827
40Meckel diverticulum (HP:0002245)2.90578567
41Intestinal fistula (HP:0100819)2.87719274
42Short humerus (HP:0005792)2.83401949
43Bifid tongue (HP:0010297)2.79688418
44Abnormality of the salivary glands (HP:0010286)2.78876931
45Impulsivity (HP:0100710)2.77333361
46Anomalous pulmonary venous return (HP:0010772)2.76767198
47Abnormality of the ileum (HP:0001549)2.74681826
48Vaginal fistula (HP:0004320)2.74193373
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.73491874
50Reduced antithrombin III activity (HP:0001976)2.72634806
51Horizontal nystagmus (HP:0000666)2.65127790
52Amyotrophic lateral sclerosis (HP:0007354)2.56303107
53Shawl scrotum (HP:0000049)2.56301513
54Preauricular skin tag (HP:0000384)2.54455412
55Nasolacrimal duct obstruction (HP:0000579)2.51157912
56Reticulocytopenia (HP:0001896)2.49838617
57Hypochromic anemia (HP:0001931)2.47311681
58Abnormality of the fovea (HP:0000493)2.46877641
59Entropion (HP:0000621)2.45553084
60Abnormality of the phalanges of the hallux (HP:0010057)2.45229960
61Pendular nystagmus (HP:0012043)2.42533849
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41161240
63Rough bone trabeculation (HP:0100670)2.38899344
64Hyperinsulinemic hypoglycemia (HP:0000825)2.38477301
65Medulloblastoma (HP:0002885)2.37865663
66Microvesicular hepatic steatosis (HP:0001414)2.36894276
67Preauricular pit (HP:0004467)2.36115584
68Periauricular skin pits (HP:0100277)2.36115584
69Secondary amenorrhea (HP:0000869)2.35900400
70Abnormal gallbladder physiology (HP:0012438)2.35321360
71Cholecystitis (HP:0001082)2.35321360
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34776900
733-Methylglutaconic aciduria (HP:0003535)2.33753095
74Abnormality of the pulmonary veins (HP:0011718)2.33714055
75Increased serum lactate (HP:0002151)2.31378977
76Hand muscle atrophy (HP:0009130)2.31066737
77Tongue fasciculations (HP:0001308)2.30396192
78Microretrognathia (HP:0000308)2.29630581
79Duodenal stenosis (HP:0100867)2.28255837
80Small intestinal stenosis (HP:0012848)2.28255837
81Proximal placement of thumb (HP:0009623)2.28147754
82Glioma (HP:0009733)2.26715293
83Type I transferrin isoform profile (HP:0003642)2.25690724
84Progressive muscle weakness (HP:0003323)2.24362817
85Skin tags (HP:0010609)2.22490278
86Facial cleft (HP:0002006)2.21633857
87Duplication of thumb phalanx (HP:0009942)2.20341896
88Abnormal number of erythroid precursors (HP:0012131)2.20158913
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.19665835
90Abnormal cartilage morphology (HP:0002763)2.18956869
91Aplastic anemia (HP:0001915)2.18614197
92Glossoptosis (HP:0000162)2.16106187
93Aplasia/Hypoplasia of the macula (HP:0008059)2.15762754
94Upper limb amyotrophy (HP:0009129)2.15668176
95Distal upper limb amyotrophy (HP:0007149)2.15668176
96Large earlobe (HP:0009748)2.14599049
97Renal Fanconi syndrome (HP:0001994)2.12882929
98Upper limb muscle weakness (HP:0003484)2.12690034
99Progressive external ophthalmoplegia (HP:0000590)2.12480905
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12259501
101Generalized hypotonia (HP:0001290)2.11685049
102Premature ovarian failure (HP:0008209)2.11559053
103Deviation of the thumb (HP:0009603)2.09586645
104Abnormality of the preputium (HP:0100587)2.09256778
105Nonimmune hydrops fetalis (HP:0001790)2.08514308
106Abnormality of chromosome segregation (HP:0002916)2.07458787
107Progressive microcephaly (HP:0000253)2.07434804
108Muscle fibrillation (HP:0010546)2.06244392
109Abnormality of cells of the erythroid lineage (HP:0012130)2.03271657
110Malignant neoplasm of the central nervous system (HP:0100836)2.02611591
111Atresia of the external auditory canal (HP:0000413)2.01009241
112Ulnar bowing (HP:0003031)2.00991643
113Sensory axonal neuropathy (HP:0003390)2.00356401
114Abnormal trabecular bone morphology (HP:0100671)1.99734284
115Short 5th finger (HP:0009237)1.99127670
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.98336817
117Hypoplasia of the pons (HP:0012110)1.97937543
118Embryonal neoplasm (HP:0002898)1.97493582
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.96589747
120Capillary hemangiomas (HP:0005306)1.95044481
121Renal duplication (HP:0000075)1.92047109
122Abnormality of the musculature of the hand (HP:0001421)1.91682295
123Selective tooth agenesis (HP:0001592)1.91218284
124Aplasia/Hypoplasia affecting the retina (HP:0008061)1.90704580
125Vertebral fusion (HP:0002948)1.89934998
126CNS hypomyelination (HP:0003429)1.89418445
127Abnormality of DNA repair (HP:0003254)1.89295361
128Abnormality of the lacrimal duct (HP:0011481)1.88951068
129Abnormality of the duodenum (HP:0002246)1.88498474
130Severe visual impairment (HP:0001141)1.88367458
131Increased intramyocellular lipid droplets (HP:0012240)1.88214967
132Postnatal microcephaly (HP:0005484)1.88121137
133Missing ribs (HP:0000921)1.88081857
134Self-mutilation (HP:0000742)1.86423924
135Increased connective tissue (HP:0009025)1.86214897
136Villous atrophy (HP:0011473)1.85472100
137Abnormality of small intestinal villus morphology (HP:0011472)1.85472100
138Broad distal phalanx of finger (HP:0009836)1.84842052
139Patellar aplasia (HP:0006443)1.84724554
140Absent radius (HP:0003974)1.84639600
141Retinal dysplasia (HP:0007973)1.84559709
142Myelodysplasia (HP:0002863)1.84057030
143Cheilitis (HP:0100825)1.82554412
144Sloping forehead (HP:0000340)1.82202259
145Long foot (HP:0001833)1.81797325
146Respiratory difficulties (HP:0002880)1.80855650
147Opisthotonus (HP:0002179)1.80810414
148Absent thumb (HP:0009777)1.80159291
149Horseshoe kidney (HP:0000085)1.80085581
150Achilles tendon contracture (HP:0001771)1.78107325
151Breech presentation (HP:0001623)1.77305999
152Cholelithiasis (HP:0001081)1.77019454
153Abnormality of cochlea (HP:0000375)1.76750291
154Abnormality of the umbilical cord (HP:0010881)1.75950203
155Facial hemangioma (HP:0000329)1.75888218
156Aplasia/Hypoplasia of the patella (HP:0006498)1.74917333
157Increased muscle lipid content (HP:0009058)1.74140300
158Abnormality of the pons (HP:0007361)1.74134453
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73874950
160Absent epiphyses (HP:0010577)1.73874950
161Increased hepatocellular lipid droplets (HP:0006565)1.73635393
162Absent forearm bone (HP:0003953)1.73506505
163Aplasia involving forearm bones (HP:0009822)1.73506505
164Cervical subluxation (HP:0003308)1.73466851
165Hepatocellular necrosis (HP:0001404)1.73223726
166Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72950621
167Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72950621
168Death in infancy (HP:0001522)1.72627698
169Abnormal mitochondria in muscle tissue (HP:0008316)1.71450902
170Premature graying of hair (HP:0002216)1.70998996
171Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70823601
172Hyperacusis (HP:0010780)1.69759249
173Increased CSF lactate (HP:0002490)1.68032203
174Abnormality of the intrinsic pathway (HP:0010989)1.66576426
175Exercise intolerance (HP:0003546)1.64952393
176Abnormalities of placenta or umbilical cord (HP:0001194)1.63850084
177Degeneration of anterior horn cells (HP:0002398)1.62069954
178Abnormality of the anterior horn cell (HP:0006802)1.62069954
179Anteriorly placed anus (HP:0001545)1.61453402
180Long palpebral fissure (HP:0000637)1.61187204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.19462199
2GRK54.94514905
3PBK4.01735609
4GRK63.94250736
5ERN13.83373540
6ADRBK23.20059470
7GRK13.03305317
8TTK2.98437504
9TESK12.91372755
10CSF1R2.78997919
11VRK22.60799888
12TGFBR22.53183470
13TSSK62.50824222
14MST1R2.47532098
15GRK72.46353945
16STK162.39945761
17MATK2.36115301
18TYRO32.30156939
19MAPK72.28140437
20PDK22.27508144
21STK102.18442692
22SMG12.07477492
23CDK72.03422359
24PLK42.01469187
25MOS1.91812149
26WNK11.76269985
27BCKDK1.69744708
28EPHA21.59983531
29BUB11.56804555
30SCYL21.56747631
31CHEK21.53870470
32CDC71.53092493
33PLK11.52867370
34PAK41.51550466
35MAP4K21.42582670
36IRAK31.39772234
37CAMK41.38741453
38NME11.34669542
39PRKG21.33014725
40WEE11.31578723
41SIK11.30079494
42TRIB31.29203941
43LMTK21.21049966
44AKT31.16580430
45MARK21.13440301
46EIF2AK31.11566358
47MAP3K101.08460757
48NTRK11.05367320
49HIPK21.03287246
50ADRBK11.02380115
51MAPK151.01187581
52CHEK11.00772776
53NEK20.99085810
54BRSK10.99022295
55SRPK10.98888681
56RPS6KA40.95895361
57EIF2AK20.93978173
58DDR20.86649413
59AKT20.85738631
60DAPK10.81366759
61SIK30.80229082
62EEF2K0.79391956
63AURKA0.78353373
64KDR0.77951939
65CCNB10.77167019
66SIK20.75537725
67TLK10.72779002
68MAP2K60.72601276
69RPS6KB20.72565178
70FGFR30.69867968
71MAP2K40.69450143
72PASK0.68836162
73MET0.68469837
74LATS20.66082363
75MAP3K110.64450568
76ERBB40.64443774
77ALK0.63635518
78AURKB0.62898568
79CDK20.62726397
80CSNK1G30.62317522
81DYRK1B0.61818789
82MUSK0.61039652
83TESK20.60664840
84MAPK110.60009778
85PRKCI0.58818169
86CDK60.58125993
87STK380.57367735
88CSK0.56804995
89PRKD30.55856916
90PAK10.54569337
91ARAF0.54488018
92DYRK30.53526316
93CSNK1G10.51786618
94CDK80.51508250
95CDK30.50795191
96CDK40.50585723
97PLK30.50268181
98ATM0.49673906
99CDK90.49347225
100CSNK1A1L0.49048954
101BMX0.47624748
102DYRK20.46784888
103ATR0.46766111
104MAPK120.46388021
105MTOR0.44987254
106CLK10.44514295
107ACVR1B0.43811111
108CDK140.42376975
109ILK0.40624515
110DAPK30.39943684
111VRK10.39116439
112BRAF0.38407379
113NEK10.38276271
114CSNK1E0.38066992
115CDK10.35791633
116IRAK20.34073916
117TAOK20.33321577
118IKBKB0.32882193
119RPS6KC10.32059122
120RPS6KL10.32059122
121MAP3K70.30676264
122PRKCD0.30262144
123BLK0.29311833
124MKNK10.29131017
125NME20.28643633
126PIM20.27476694
127MAPKAPK30.25075501
128IGF1R0.24277498
129MAPK10.21427161
130GSK3B0.21313309
131MAPK140.20919782
132MKNK20.20844550
133ICK0.20775495
134STK38L0.20359264
135MAPK100.19775501
136CDK11A0.19233638
137PDK40.19121537
138PDK30.19121537
139CSNK2A10.18738487
140STK40.18327315
141PIM10.17460085
142YES10.17391046
143CDK150.17366749
144PRPF4B0.17064758
145ERBB20.16726474
146PTK20.16568674
147INSR0.16018248
148CDK180.15874200
149MAPK40.14542289
150ITK0.14477820
151MAP3K80.13660508
152CSNK2A20.13629873
153EIF2AK10.13433592
154ZAK0.12412142

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.86803929
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.73753351
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.65580683
4DNA replication_Homo sapiens_hsa030303.18080491
5Fructose and mannose metabolism_Homo sapiens_hsa000513.04701422
6Ribosome_Homo sapiens_hsa030102.76555484
7Mismatch repair_Homo sapiens_hsa034302.69625528
8RNA transport_Homo sapiens_hsa030132.61081126
9Arachidonic acid metabolism_Homo sapiens_hsa005902.38250320
10Fanconi anemia pathway_Homo sapiens_hsa034602.36515421
11Homologous recombination_Homo sapiens_hsa034402.22509055
12Spliceosome_Homo sapiens_hsa030402.15333777
13Galactose metabolism_Homo sapiens_hsa000522.12773925
14RNA polymerase_Homo sapiens_hsa030202.12663289
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05168960
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00546175
17Cell cycle_Homo sapiens_hsa041101.99277725
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96298243
19Base excision repair_Homo sapiens_hsa034101.92834923
20One carbon pool by folate_Homo sapiens_hsa006701.89254209
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88680339
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82486703
23mRNA surveillance pathway_Homo sapiens_hsa030151.80542858
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79691677
25Linoleic acid metabolism_Homo sapiens_hsa005911.77953158
26RNA degradation_Homo sapiens_hsa030181.74249677
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61180089
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58288301
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57054532
30Nucleotide excision repair_Homo sapiens_hsa034201.52021447
31Basal transcription factors_Homo sapiens_hsa030221.47830223
32Pyrimidine metabolism_Homo sapiens_hsa002401.42403157
33N-Glycan biosynthesis_Homo sapiens_hsa005101.42135568
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40120808
35Thyroid cancer_Homo sapiens_hsa052161.37217480
36Steroid biosynthesis_Homo sapiens_hsa001001.35788025
37Proteasome_Homo sapiens_hsa030501.29804386
38Fatty acid elongation_Homo sapiens_hsa000621.25649847
39p53 signaling pathway_Homo sapiens_hsa041151.23020198
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21488075
41Pyruvate metabolism_Homo sapiens_hsa006201.15079511
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10037949
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07346028
44Basal cell carcinoma_Homo sapiens_hsa052170.99670193
45Selenocompound metabolism_Homo sapiens_hsa004500.99105768
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97753528
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97047114
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96831514
49Non-homologous end-joining_Homo sapiens_hsa034500.94234361
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93902148
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93572934
52Other glycan degradation_Homo sapiens_hsa005110.85279826
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83959656
54Parkinsons disease_Homo sapiens_hsa050120.81626751
55mTOR signaling pathway_Homo sapiens_hsa041500.80157040
56Hedgehog signaling pathway_Homo sapiens_hsa043400.79066536
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78808373
58Herpes simplex infection_Homo sapiens_hsa051680.78645964
59Sulfur relay system_Homo sapiens_hsa041220.78031034
60Pentose phosphate pathway_Homo sapiens_hsa000300.73388211
61MicroRNAs in cancer_Homo sapiens_hsa052060.71888858
62Pathways in cancer_Homo sapiens_hsa052000.69233419
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67542761
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.66582727
65Ether lipid metabolism_Homo sapiens_hsa005650.65014256
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64999942
67Folate biosynthesis_Homo sapiens_hsa007900.64822520
68Hippo signaling pathway_Homo sapiens_hsa043900.61781985
69Phenylalanine metabolism_Homo sapiens_hsa003600.61553936
70Protein export_Homo sapiens_hsa030600.61221537
71Oxidative phosphorylation_Homo sapiens_hsa001900.60936573
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60587500
73Purine metabolism_Homo sapiens_hsa002300.60420572
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58033507
75Lysine degradation_Homo sapiens_hsa003100.57931103
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.57277790
77Acute myeloid leukemia_Homo sapiens_hsa052210.54913070
78Vibrio cholerae infection_Homo sapiens_hsa051100.53886198
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52369698
80Notch signaling pathway_Homo sapiens_hsa043300.50164169
81Wnt signaling pathway_Homo sapiens_hsa043100.48440539
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.48041739
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48022883
84Arginine and proline metabolism_Homo sapiens_hsa003300.47245531
85Ovarian steroidogenesis_Homo sapiens_hsa049130.47039899
86Bladder cancer_Homo sapiens_hsa052190.46535337
87Biosynthesis of amino acids_Homo sapiens_hsa012300.46041117
88HTLV-I infection_Homo sapiens_hsa051660.46021098
89Chemical carcinogenesis_Homo sapiens_hsa052040.44088380
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43389573
91Fatty acid metabolism_Homo sapiens_hsa012120.42808372
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41476743
93Apoptosis_Homo sapiens_hsa042100.40268561
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39572405
95Viral carcinogenesis_Homo sapiens_hsa052030.39536734
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39120133
97Rap1 signaling pathway_Homo sapiens_hsa040150.37087979
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36883662
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35821068
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.35285183
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34836170
102Carbon metabolism_Homo sapiens_hsa012000.33118149
103Fatty acid biosynthesis_Homo sapiens_hsa000610.32913629
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.32124214
105African trypanosomiasis_Homo sapiens_hsa051430.30202506
106Oocyte meiosis_Homo sapiens_hsa041140.29941055
107Regulation of autophagy_Homo sapiens_hsa041400.29521099
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29043562
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28397387
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.28135440
111Choline metabolism in cancer_Homo sapiens_hsa052310.27794871
112Epstein-Barr virus infection_Homo sapiens_hsa051690.27346605
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27327380
114Metabolic pathways_Homo sapiens_hsa011000.26626855
115Chronic myeloid leukemia_Homo sapiens_hsa052200.26543301
116Tyrosine metabolism_Homo sapiens_hsa003500.25279936
117Legionellosis_Homo sapiens_hsa051340.24761534
118AMPK signaling pathway_Homo sapiens_hsa041520.24327366
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24106402
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23524557
121Tight junction_Homo sapiens_hsa045300.23161703
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22955537
123Small cell lung cancer_Homo sapiens_hsa052220.22804639
124Arginine biosynthesis_Homo sapiens_hsa002200.22597209
125Primary immunodeficiency_Homo sapiens_hsa053400.22376574
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.22019724
127Non-small cell lung cancer_Homo sapiens_hsa052230.21907158
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20525852
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.19952525
130Hepatitis B_Homo sapiens_hsa051610.19714102
131Prostate cancer_Homo sapiens_hsa052150.19570405
132Huntingtons disease_Homo sapiens_hsa050160.19151891
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18111065
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17983954
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17645152
136Alzheimers disease_Homo sapiens_hsa050100.16150007
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13339734
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.13309817
139Adherens junction_Homo sapiens_hsa045200.13125377
140TGF-beta signaling pathway_Homo sapiens_hsa043500.12890061
141Glutathione metabolism_Homo sapiens_hsa004800.12557536
142Ras signaling pathway_Homo sapiens_hsa040140.12016367

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