MSX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)8.81821701
2hair cycle (GO:0042633)8.81821701
3lateral sprouting from an epithelium (GO:0060601)5.77658208
4mesenchymal cell proliferation (GO:0010463)4.96917692
5regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.80680808
6paraxial mesoderm development (GO:0048339)4.77899529
7desmosome organization (GO:0002934)4.66743363
8regulation of cardioblast differentiation (GO:0051890)4.40634330
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.27798331
10regulation of mesoderm development (GO:2000380)4.20806748
11establishment of tissue polarity (GO:0007164)4.18367350
12establishment of planar polarity (GO:0001736)4.18367350
13negative regulation of embryonic development (GO:0045992)4.04290193
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.01372057
15negative regulation of cell fate specification (GO:0009996)4.00068820
16negative regulation of stem cell proliferation (GO:2000647)3.82156834
17cell proliferation involved in metanephros development (GO:0072203)3.79964647
18hair follicle morphogenesis (GO:0031069)3.77406427
19mesenchymal-epithelial cell signaling (GO:0060638)3.74244008
20* epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.73368322
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.69759046
22intermediate filament organization (GO:0045109)3.68495257
23trophectodermal cell differentiation (GO:0001829)3.67399477
24bundle of His cell to Purkinje myocyte communication (GO:0086069)3.64564030
25lung-associated mesenchyme development (GO:0060484)3.62121614
26cell proliferation involved in kidney development (GO:0072111)3.61968788
27* cell surface receptor signaling pathway involved in heart development (GO:0061311)3.54676915
28regulation of cell proliferation involved in kidney development (GO:1901722)3.53404764
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.52577624
30polarized epithelial cell differentiation (GO:0030859)3.49196062
31branching involved in salivary gland morphogenesis (GO:0060445)3.47982149
32regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.46113120
33cellular protein complex localization (GO:0034629)3.41196232
34* regulation of mesenchymal cell apoptotic process (GO:2001053)3.37877823
35keratinization (GO:0031424)3.34247707
36eyelid development in camera-type eye (GO:0061029)3.33817719
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.30260780
38axon extension involved in axon guidance (GO:0048846)3.30260780
39non-canonical Wnt signaling pathway (GO:0035567)3.26561444
40positive regulation of catenin import into nucleus (GO:0035413)3.25871316
41Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.24739387
42* embryonic forelimb morphogenesis (GO:0035115)3.24620535
43uterus development (GO:0060065)3.23570780
44mitotic metaphase plate congression (GO:0007080)3.22974140
45negative regulation of keratinocyte proliferation (GO:0010839)3.22153662
46intestinal epithelial cell development (GO:0060576)3.21704243
47protein complex localization (GO:0031503)3.21505124
48COPI coating of Golgi vesicle (GO:0048205)3.21343997
49Golgi transport vesicle coating (GO:0048200)3.21343997
50negative regulation of smooth muscle cell differentiation (GO:0051151)3.16890900
51mitotic chromosome condensation (GO:0007076)3.15969886
52sequestering of extracellular ligand from receptor (GO:0035581)3.15715845
53cartilage morphogenesis (GO:0060536)3.15270309
54regulation of establishment of planar polarity (GO:0090175)3.13134652
55cochlea morphogenesis (GO:0090103)3.12423401
56limb bud formation (GO:0060174)3.12062704
57protein localization to chromosome, centromeric region (GO:0071459)3.07667528
58hair cycle process (GO:0022405)3.07314651
59molting cycle process (GO:0022404)3.07314651
60regulation of keratinocyte proliferation (GO:0010837)3.06838761
61branch elongation of an epithelium (GO:0060602)3.06158386
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05339584
63somatic stem cell division (GO:0048103)3.05220157
64negative regulation of striated muscle cell apoptotic process (GO:0010664)3.05205362
65regulation of cell fate specification (GO:0042659)3.04765094
66maturation of SSU-rRNA (GO:0030490)3.04541279
67axis elongation (GO:0003401)3.02162675
68regulation of organ formation (GO:0003156)3.01763004
69* outflow tract septum morphogenesis (GO:0003148)3.01210534
70regulation of sister chromatid cohesion (GO:0007063)2.99951601
71branching involved in prostate gland morphogenesis (GO:0060442)2.99262896
72* hindlimb morphogenesis (GO:0035137)2.98890384
73* forelimb morphogenesis (GO:0035136)2.96821643
74mesonephros development (GO:0001823)2.96559968
75negative chemotaxis (GO:0050919)2.96251273
76establishment of apical/basal cell polarity (GO:0035089)2.95609998
77ribosomal small subunit biogenesis (GO:0042274)2.95504476
78hippo signaling (GO:0035329)2.95408994
79cardiac right ventricle morphogenesis (GO:0003215)2.94211159
80* embryonic hindlimb morphogenesis (GO:0035116)2.93711786
81maternal placenta development (GO:0001893)2.93558667
82notochord development (GO:0030903)2.92508320
83odontogenesis of dentin-containing tooth (GO:0042475)2.91982126
84* cranial suture morphogenesis (GO:0060363)2.91856301
85mesenchyme development (GO:0060485)2.90557351
86ear development (GO:0043583)2.90044073
87regulation of catenin import into nucleus (GO:0035412)2.89159582
88embryonic cranial skeleton morphogenesis (GO:0048701)2.88380074
89cell differentiation involved in embryonic placenta development (GO:0060706)2.88304090
90* regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.87951247
91regulation of smooth muscle cell differentiation (GO:0051150)2.87927223
92outer ear morphogenesis (GO:0042473)2.86854813
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.86623668
94* embryonic appendage morphogenesis (GO:0035113)2.86506584
95* embryonic limb morphogenesis (GO:0030326)2.86506584
96negative regulation of cell fate commitment (GO:0010454)2.85932100
97regulation of odontogenesis (GO:0042481)2.85813447
98mesenchymal cell differentiation (GO:0048762)2.84800318
99protein localization to kinetochore (GO:0034501)2.83673982
100prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.83415244
101dorsal/ventral neural tube patterning (GO:0021904)2.83060590
102mammary gland epithelial cell differentiation (GO:0060644)2.82880872
103regulation of gene silencing by RNA (GO:0060966)2.82420091
104regulation of posttranscriptional gene silencing (GO:0060147)2.82420091
105regulation of gene silencing by miRNA (GO:0060964)2.82420091
106mesenchyme morphogenesis (GO:0072132)2.81998174
107* epithelial to mesenchymal transition (GO:0001837)2.81875119
108DNA replication checkpoint (GO:0000076)2.81501394
109* craniofacial suture morphogenesis (GO:0097094)2.81491523
110regulation of transforming growth factor beta2 production (GO:0032909)2.80727666
111formation of translation preinitiation complex (GO:0001731)2.79949313
112embryonic skeletal joint morphogenesis (GO:0060272)2.78998121
113regulation of centriole replication (GO:0046599)2.78979309
114daunorubicin metabolic process (GO:0044597)2.78749612
115polyketide metabolic process (GO:0030638)2.78749612
116doxorubicin metabolic process (GO:0044598)2.78749612
117chondrocyte proliferation (GO:0035988)2.77468381
118odontogenesis (GO:0042476)2.72721407
119ribosomal small subunit assembly (GO:0000028)2.72437952
120proline biosynthetic process (GO:0006561)2.72427989
121prostate gland epithelium morphogenesis (GO:0060740)2.72161255
122ventricular cardiac muscle cell development (GO:0055015)2.71892543
123positive regulation of epithelial to mesenchymal transition (GO:0010718)2.71165200
124endocrine hormone secretion (GO:0060986)2.71157392
125negative regulation of axon guidance (GO:1902668)2.71051718
126cornea development in camera-type eye (GO:0061303)2.70650693
127regulation of translational termination (GO:0006449)2.70332751
128extracellular regulation of signal transduction (GO:1900115)2.69289572
129extracellular negative regulation of signal transduction (GO:1900116)2.69289572
130* appendage morphogenesis (GO:0035107)2.68256657
131* limb morphogenesis (GO:0035108)2.68256657
132negative regulation of catenin import into nucleus (GO:0035414)2.67904906
133negative regulation of chondrocyte differentiation (GO:0032331)2.67711693
134establishment of monopolar cell polarity (GO:0061162)2.65890584
135establishment or maintenance of monopolar cell polarity (GO:0061339)2.65890584
136CENP-A containing nucleosome assembly (GO:0034080)2.64235341
137cell migration involved in heart development (GO:0060973)2.64028258
138DNA replication initiation (GO:0006270)2.63936291
139ribosome assembly (GO:0042255)2.62543376
140ribosome biogenesis (GO:0042254)2.62540231
141keratinocyte differentiation (GO:0030216)2.60932002
142DNA strand elongation (GO:0022616)2.60486947
143artery development (GO:0060840)2.59445818
144dorsal/ventral axis specification (GO:0009950)2.59403845
145embryonic heart tube development (GO:0035050)2.57432410
146DNA strand elongation involved in DNA replication (GO:0006271)2.57233247
147DNA unwinding involved in DNA replication (GO:0006268)2.55164260
148epithelial tube branching involved in lung morphogenesis (GO:0060441)2.54880874
149metaphase plate congression (GO:0051310)2.52734686
150peptidyl-arginine omega-N-methylation (GO:0035247)2.52626078
151embryonic camera-type eye morphogenesis (GO:0048596)2.52522862
152ribonucleoprotein complex biogenesis (GO:0022613)2.51697975
153chromatin remodeling at centromere (GO:0031055)2.49254621
154positive regulation of epidermal cell differentiation (GO:0045606)2.45993724
155negative regulation of DNA repair (GO:0045738)2.44096211
156establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43693324
157epithelial cell maturation (GO:0002070)2.43457203
158embryonic eye morphogenesis (GO:0048048)2.42839983
159negative regulation of kidney development (GO:0090185)2.40702175
160regulation of striated muscle cell apoptotic process (GO:0010662)2.39404227
161nuclear pore complex assembly (GO:0051292)2.37938629
162lymph vessel development (GO:0001945)2.37927320
163viral transcription (GO:0019083)2.35439490
164embryonic process involved in female pregnancy (GO:0060136)2.33184863
165trophoblast giant cell differentiation (GO:0060707)2.31994722
166keratinocyte development (GO:0003334)2.31983373
167translational termination (GO:0006415)2.30568557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.84916165
2* TP63_19390658_ChIP-ChIP_HaCaT_Human4.13338652
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13426430
4E2F7_22180533_ChIP-Seq_HELA_Human2.94842020
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.93831329
6ESR1_15608294_ChIP-ChIP_MCF-7_Human2.92876470
7ZNF263_19887448_ChIP-Seq_K562_Human2.92068590
8* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.82014310
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.65799535
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65305347
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63599397
12* TP53_20018659_ChIP-ChIP_R1E_Mouse2.62903722
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.61617101
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.60323056
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.58621268
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57116883
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.54395311
18* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.52587813
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.50813950
20* CBX2_27304074_Chip-Seq_ESCs_Mouse2.44308133
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.43653381
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.42504062
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42271629
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33301018
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26984475
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19526637
27XRN2_22483619_ChIP-Seq_HELA_Human2.18493659
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14744612
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12462887
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.07305616
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03301358
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96969573
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.96520873
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93541588
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90746413
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90746413
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90746413
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89670537
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88346845
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86190909
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85466999
42* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82051554
43* E2F1_21310950_ChIP-Seq_MCF-7_Human1.81879458
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81079809
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80908582
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80509223
47DCP1A_22483619_ChIP-Seq_HELA_Human1.78549577
48* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78066521
49* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78066521
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75519512
51* RNF2_27304074_Chip-Seq_ESCs_Mouse1.74591742
52TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.70622026
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66733331
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65915951
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.65068361
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64117974
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.61299970
58* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57860148
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55910987
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54537068
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.53776113
62* ISL1_27105846_Chip-Seq_CPCs_Mouse1.53643030
63TP53_18474530_ChIP-ChIP_U2OS_Human1.53497122
64TTF2_22483619_ChIP-Seq_HELA_Human1.53454855
65* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53384335
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52683929
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52100823
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.51088534
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.49967572
70* RING1B_27294783_Chip-Seq_NPCs_Mouse1.45777907
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.45418221
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45302047
73KDM5A_27292631_Chip-Seq_BREAST_Human1.44767065
74* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41869956
75* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40646417
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39784844
77* RNF2_27304074_Chip-Seq_NSC_Mouse1.39186797
78* GATA3_24758297_ChIP-Seq_MCF-7_Human1.37531780
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36991762
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36043059
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34642122
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34502426
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32511121
84* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32461843
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31633450
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31581623
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.31519084
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.31266043
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30720292
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29476015
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.29373314
92FUS_26573619_Chip-Seq_HEK293_Human1.28738966
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27465753
94GABP_19822575_ChIP-Seq_HepG2_Human1.27200631
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26862880
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.24980223
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24932061
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24537656
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23690219
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23596149
101* RING1B_27294783_Chip-Seq_ESCs_Mouse1.23123578
102* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22441750
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19957953
104* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19116289
105EWS_26573619_Chip-Seq_HEK293_Human1.18270078
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17388537
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17372533
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17089468
109* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16922335
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.16894309
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16322867
112* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15583943
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14661893
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13619665
115* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12580632
116ELF5_23300383_ChIP-Seq_T47D_Human1.11577109
117MYC_18555785_ChIP-Seq_MESCs_Mouse1.10883473
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.09924674
119CHD1_26751641_Chip-Seq_LNCaP_Human1.09172843
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09069243
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09069243
122* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09006639
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07939906
124* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07474721
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07350564
126EST1_17652178_ChIP-ChIP_JURKAT_Human1.07046397
127ATF3_27146783_Chip-Seq_COLON_Human1.07005482
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06484156
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06462260
130TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04189136
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03833369
132BRD4_25478319_ChIP-Seq_HGPS_Human1.02101557
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01121611
134* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00366005
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99939084
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98441517
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97018393
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96702870
139* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94898756
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94791293
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94152909
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93827461
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93654891
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93623890
145* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93326829
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92368135
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.92265833
148* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92024854
149* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91356267
150* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90818900
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90670542
152* GATA6_25053715_ChIP-Seq_YYC3_Human0.90555750
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90326104
154* PIAS1_25552417_ChIP-Seq_VCAP_Human0.90121283
155MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89949781
156* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89946552
157AR_21909140_ChIP-Seq_LNCAP_Human0.89798624
158SOX9_26525672_Chip-Seq_HEART_Mouse0.89246054
159CJUN_26792858_Chip-Seq_BT549_Human0.88532763
160POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87596039
161SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85957976
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85611868
163SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85248157
164* SMAD3_21741376_ChIP-Seq_EPCs_Human0.82306667
165* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.80753822
166EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80689122
167* ARNT_22903824_ChIP-Seq_MCF-7_Human0.79851906
168* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79266998
169CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78601635
170POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77496593
171* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77279864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.10969547
2MP0009053_abnormal_anal_canal3.28699099
3MP0010234_abnormal_vibrissa_follicle3.17937856
4* MP0002098_abnormal_vibrissa_morphology3.14883920
5MP0010030_abnormal_orbit_morphology3.14361719
6MP0000579_abnormal_nail_morphology3.13596065
7MP0000647_abnormal_sebaceous_gland3.00385094
8MP0000383_abnormal_hair_follicle2.95122123
9MP0003941_abnormal_skin_development2.89016937
10MP0003693_abnormal_embryo_hatching2.72249388
11MP0000537_abnormal_urethra_morphology2.57347787
12MP0005275_abnormal_skin_tensile2.50259471
13MP0003385_abnormal_body_wall2.34541950
14MP0002102_abnormal_ear_morphology2.25677985
15MP0001346_abnormal_lacrimal_gland2.21293111
16MP0003937_abnormal_limbs/digits/tail_de2.20001716
17MP0010678_abnormal_skin_adnexa2.19515479
18MP0000427_abnormal_hair_cycle2.17697844
19MP0005248_abnormal_Harderian_gland2.15591173
20MP0005503_abnormal_tendon_morphology2.10431308
21MP0005076_abnormal_cell_differentiation2.03502381
22MP0009250_abnormal_appendicular_skeleto1.99730177
23MP0003122_maternal_imprinting1.99071542
24MP0003121_genomic_imprinting1.90412655
25MP0000762_abnormal_tongue_morphology1.84677126
26MP0000516_abnormal_urinary_system1.84272289
27MP0005367_renal/urinary_system_phenotyp1.84272289
28MP0002938_white_spotting1.80365334
29MP0000377_abnormal_hair_follicle1.79874476
30MP0003315_abnormal_perineum_morphology1.77573734
31MP0000049_abnormal_middle_ear1.76988285
32MP0010094_abnormal_chromosome_stability1.74002394
33MP0002160_abnormal_reproductive_system1.70418772
34MP0001293_anophthalmia1.69326346
35MP0003123_paternal_imprinting1.65806432
36MP0004272_abnormal_basement_membrane1.64931707
37MP0003077_abnormal_cell_cycle1.64070980
38MP0002796_impaired_skin_barrier1.63488556
39MP0006292_abnormal_olfactory_placode1.63019277
40MP0003942_abnormal_urinary_system1.58684130
41* MP0003755_abnormal_palate_morphology1.55203020
42MP0003705_abnormal_hypodermis_morpholog1.54544332
43MP0005257_abnormal_intraocular_pressure1.53940672
44MP0002249_abnormal_larynx_morphology1.53172484
45MP0003111_abnormal_nucleus_morphology1.50206035
46MP0009672_abnormal_birth_weight1.49528967
47MP0002282_abnormal_trachea_morphology1.49117307
48MP0008057_abnormal_DNA_replication1.47891773
49MP0002932_abnormal_joint_morphology1.44855186
50MP0002177_abnormal_outer_ear1.42986921
51* MP0000432_abnormal_head_morphology1.36598577
52MP0000428_abnormal_craniofacial_morphol1.36576477
53MP0001243_abnormal_dermal_layer1.36463056
54* MP0003935_abnormal_craniofacial_develop1.36283144
55MP0005187_abnormal_penis_morphology1.34779200
56MP0005508_abnormal_skeleton_morphology1.33563993
57MP0008438_abnormal_cutaneous_collagen1.32225079
58MP0004185_abnormal_adipocyte_glucose1.30826037
59MP0003938_abnormal_ear_development1.28722893
60MP0002234_abnormal_pharynx_morphology1.28687633
61MP0003119_abnormal_digestive_system1.28464737
62MP0004381_abnormal_hair_follicle1.28077810
63MP0001730_embryonic_growth_arrest1.26650050
64MP0002233_abnormal_nose_morphology1.26623030
65MP0004782_abnormal_surfactant_physiolog1.25283648
66* MP0002116_abnormal_craniofacial_bone1.22464318
67MP0001697_abnormal_embryo_size1.21841327
68MP0002111_abnormal_tail_morphology1.20908050
69MP0005501_abnormal_skin_physiology1.18224398
70MP0004233_abnormal_muscle_weight1.16936494
71* MP0003984_embryonic_growth_retardation1.16871638
72* MP0002088_abnormal_embryonic_growth/wei1.16542420
73MP0002697_abnormal_eye_size1.14051646
74MP0010352_gastrointestinal_tract_polyps1.12838108
75* MP0000627_abnormal_mammary_gland1.11908214
76MP0002086_abnormal_extraembryonic_tissu1.11657630
77MP0002653_abnormal_ependyma_morphology1.11080560
78MP0000467_abnormal_esophagus_morphology1.10415193
79MP0001286_abnormal_eye_development1.10071276
80MP0005623_abnormal_meninges_morphology1.09143987
81MP0003115_abnormal_respiratory_system1.08915427
82MP0003566_abnormal_cell_adhesion1.07792416
83MP0000350_abnormal_cell_proliferation1.06152474
84MP0002060_abnormal_skin_morphology1.03845007
85MP0010307_abnormal_tumor_latency1.01926675
86MP0000534_abnormal_ureter_morphology1.00878194
87* MP0002109_abnormal_limb_morphology0.99884379
88MP0001216_abnormal_epidermal_layer0.98509638
89MP0003567_abnormal_fetal_cardiomyocyte0.97432890
90MP0002084_abnormal_developmental_patter0.96025364
91MP0002080_prenatal_lethality0.95571572
92MP0009703_decreased_birth_body0.94530923
93MP0005409_darkened_coat_color0.93755690
94MP0003890_abnormal_embryonic-extraembry0.92732226
95MP0002085_abnormal_embryonic_tissue0.92372145
96MP0010771_integument_phenotype0.92220931
97MP0001340_abnormal_eyelid_morphology0.91590275
98MP0001919_abnormal_reproductive_system0.90386683
99MP0003283_abnormal_digestive_organ0.90365474
100MP0001881_abnormal_mammary_gland0.89471304
101MP0004197_abnormal_fetal_growth/weight/0.89292240
102MP0008932_abnormal_embryonic_tissue0.88428985
103MP0003136_yellow_coat_color0.87872916
104MP0005377_hearing/vestibular/ear_phenot0.86381284
105MP0003878_abnormal_ear_physiology0.86381284
106MP0000462_abnormal_digestive_system0.85884896
107MP0001299_abnormal_eye_distance/0.85471693
108MP0005171_absent_coat_pigmentation0.84939173
109MP0002009_preneoplasia0.84789039
110MP0001188_hyperpigmentation0.84513387
111MP0002114_abnormal_axial_skeleton0.83768170
112MP0005197_abnormal_uvea_morphology0.81018682
113MP0004264_abnormal_extraembryonic_tissu0.80820355
114MP0005389_reproductive_system_phenotype0.80272517
115MP0009384_cardiac_valve_regurgitation0.79877826
116MP0004858_abnormal_nervous_system0.79457028
117MP0000733_abnormal_muscle_development0.77253790
118MP0002092_abnormal_eye_morphology0.75898632
119MP0003279_aneurysm0.75859094
120* MP0000163_abnormal_cartilage_morphology0.75765383
121MP0002254_reproductive_system_inflammat0.75540136
122MP0008007_abnormal_cellular_replicative0.75331923
123* MP0003861_abnormal_nervous_system0.74462604
124* MP0005380_embryogenesis_phenotype0.74357455
125* MP0001672_abnormal_embryogenesis/_devel0.74357455
126MP0004957_abnormal_blastocyst_morpholog0.73381644
127MP0000678_abnormal_parathyroid_gland0.71607743
128* MP0003936_abnormal_reproductive_system0.71575277
129* MP0000367_abnormal_coat/_hair0.70648627

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)4.67723146
2Woolly hair (HP:0002224)4.30439946
3Septate vagina (HP:0001153)4.24547322
4Abnormal umbilical cord blood vessels (HP:0011403)4.10862216
5Single umbilical artery (HP:0001195)4.10862216
6Abnormality of the fetal cardiovascular system (HP:0010948)4.10862216
7Abnormality of hair growth rate (HP:0011363)3.93360622
8Slow-growing hair (HP:0002217)3.93360622
9Pili torti (HP:0003777)3.86043124
10Amelogenesis imperfecta (HP:0000705)3.70549594
11Concave nail (HP:0001598)3.62131597
12Abnormality of the umbilical cord (HP:0010881)3.54054082
13Right ventricular cardiomyopathy (HP:0011663)3.44148569
14* Abnormality of the parietal bone (HP:0002696)3.19113809
15Unilateral renal agenesis (HP:0000122)3.15787764
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09435248
17Short 4th metacarpal (HP:0010044)3.09435248
18Abnormality of the distal phalanges of the toes (HP:0010182)3.06866333
19Short middle phalanx of the 5th finger (HP:0004220)3.01979458
20Bilateral microphthalmos (HP:0007633)2.97701892
21Asymmetry of the thorax (HP:0001555)2.88057389
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86152634
23Follicular hyperkeratosis (HP:0007502)2.75821670
24Shallow orbits (HP:0000586)2.75594302
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74409358
26Abnormality of the distal phalanx of the thumb (HP:0009617)2.72729226
27Onycholysis (HP:0001806)2.63623263
28Fragile nails (HP:0001808)2.58185203
29Lip pit (HP:0100267)2.56767164
30Abnormality of the 4th metacarpal (HP:0010012)2.47945867
31Abnormality of the nasolacrimal system (HP:0000614)2.46385568
32Supernumerary ribs (HP:0005815)2.45951465
33Chromsome breakage (HP:0040012)2.45322692
34Abnormal number of incisors (HP:0011064)2.45071197
35Myelomeningocele (HP:0002475)2.44164337
36Mesomelia (HP:0003027)2.41161400
37Fibular aplasia (HP:0002990)2.39694115
38Coronal craniosynostosis (HP:0004440)2.38602807
39Bicornuate uterus (HP:0000813)2.37430161
40Nasolacrimal duct obstruction (HP:0000579)2.37171484
41Nail dystrophy (HP:0008404)2.36421634
42Abnormalities of placenta or umbilical cord (HP:0001194)2.34009299
43Hypoplastic labia majora (HP:0000059)2.32752174
44Abnormality of the nasal septum (HP:0000419)2.31392232
45Abnormality of the phalanges of the hallux (HP:0010057)2.31116048
46Sparse lateral eyebrow (HP:0005338)2.31041067
47Brittle hair (HP:0002299)2.30322763
48Midline defect of the nose (HP:0004122)2.30312637
49Birth length less than 3rd percentile (HP:0003561)2.28812489
50Bifid tongue (HP:0010297)2.28398777
51Abnormality of the lacrimal duct (HP:0011481)2.26970680
52Recurrent corneal erosions (HP:0000495)2.26346516
53Breast carcinoma (HP:0003002)2.26272741
54Supernumerary bones of the axial skeleton (HP:0009144)2.26006744
55Abnormality of the frontal sinuses (HP:0002687)2.25897259
56Microglossia (HP:0000171)2.24306784
57Preaxial foot polydactyly (HP:0001841)2.21952579
58Abnormal tarsal ossification (HP:0008369)2.21519939
59Trigonocephaly (HP:0000243)2.21096477
60Abnormal connection of the cardiac segments (HP:0011545)2.20656556
61Abnormal ventriculo-arterial connection (HP:0011563)2.20656556
62Transposition of the great arteries (HP:0001669)2.20656556
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.19054885
64Hypoparathyroidism (HP:0000829)2.18744699
65Ridged nail (HP:0001807)2.17060647
66Absent radius (HP:0003974)2.16179349
67* Aplasia cutis congenita (HP:0001057)2.16020104
68Partial duplication of the phalanx of hand (HP:0009999)2.15978055
69Selective tooth agenesis (HP:0001592)2.15844502
70Absent eyelashes (HP:0000561)2.15217771
71Premature rupture of membranes (HP:0001788)2.15035889
72Abnormality of the incisor (HP:0000676)2.13635229
73Fine hair (HP:0002213)2.12845030
74Absent forearm bone (HP:0003953)2.12366273
75Aplasia involving forearm bones (HP:0009822)2.12366273
76Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.12322229
77Broad toe (HP:0001837)2.12107402
78Sparse eyelashes (HP:0000653)2.11768876
79Overriding aorta (HP:0002623)2.07888424
80Microretrognathia (HP:0000308)2.07176770
81Abnormality of the labia majora (HP:0012881)2.07040045
82Premature skin wrinkling (HP:0100678)2.05954155
83Abnormality of nail color (HP:0100643)2.05128248
84Hypoplastic left heart (HP:0004383)2.03890675
85Parakeratosis (HP:0001036)2.03567708
86Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.03252348
87Broad distal phalanx of finger (HP:0009836)2.02580120
88Anophthalmia (HP:0000528)2.01938803
89Ectopic anus (HP:0004397)2.01574079
90Congenital, generalized hypertrichosis (HP:0004540)2.00856502
91Deviation of the thumb (HP:0009603)2.00741678
92Short 5th finger (HP:0009237)2.00386820
93Abnormality of the phalanges of the 5th finger (HP:0004213)2.00077417
94Morphological abnormality of the middle ear (HP:0008609)1.98886587
95Abnormality of the middle phalanges of the toes (HP:0010183)1.98579775
96High anterior hairline (HP:0009890)1.98198642
97Abnormality of the 2nd finger (HP:0004100)1.97979453
98Protrusio acetabuli (HP:0003179)1.97625868
99Ulnar bowing (HP:0003031)1.96643157
100Natal tooth (HP:0000695)1.95894267
101Absent eyebrow (HP:0002223)1.95871385
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.95847144
103Double outlet right ventricle (HP:0001719)1.94472294
104Congenital malformation of the right heart (HP:0011723)1.94472294
105Micronodular cirrhosis (HP:0001413)1.92336420
106Abnormality of molar morphology (HP:0011070)1.92045739
107Abnormality of molar (HP:0011077)1.92045739
108Tracheal stenosis (HP:0002777)1.92033231
109Abnormal hair laboratory examination (HP:0003328)1.91288148
110Atrophic scars (HP:0001075)1.90889675
111Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.90742904
112Cervical subluxation (HP:0003308)1.89440874
113Ectopic kidney (HP:0000086)1.88901788
114Down-sloping shoulders (HP:0200021)1.88209717
115Milia (HP:0001056)1.88059070
116Insomnia (HP:0100785)1.87871575
117Proximal placement of thumb (HP:0009623)1.87870054
118Spinal cord lesions (HP:0100561)1.87807282
119Syringomyelia (HP:0003396)1.87807282
120Increased number of teeth (HP:0011069)1.87217084
121Atresia of the external auditory canal (HP:0000413)1.87051168
122Renal duplication (HP:0000075)1.86498134
123Hyperacusis (HP:0010780)1.86421041
124Cutaneous finger syndactyly (HP:0010554)1.85750611
125Abnormality of the dental root (HP:0006486)1.85093456
126Taurodontia (HP:0000679)1.85093456
127Abnormality of permanent molar morphology (HP:0011071)1.85093456
128Aplasia involving bones of the extremities (HP:0009825)1.84417846
129Aplasia involving bones of the upper limbs (HP:0009823)1.84417846
130Aplasia of the phalanges of the hand (HP:0009802)1.84417846
131Leiomyosarcoma (HP:0100243)1.84087353
132Uterine leiomyosarcoma (HP:0002891)1.84087353
133Abnormal lung lobation (HP:0002101)1.83266145
134Short middle phalanx of finger (HP:0005819)1.83253648
135Curly hair (HP:0002212)1.83206863
136Sparse scalp hair (HP:0002209)1.82673477
137Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82588441
138Abnormality of the preputium (HP:0100587)1.81950085
139Abnormality of the gastric mucosa (HP:0004295)1.81358714
140Broad thumb (HP:0011304)1.79925297
141Conical tooth (HP:0000698)1.79727912
142Alopecia of scalp (HP:0002293)1.79526691
143Abnormality of incisor morphology (HP:0011063)1.79127459
144Skin pits (HP:0100276)1.78611593
145Synostosis of carpal bones (HP:0005048)1.77864588
146Duplication of thumb phalanx (HP:0009942)1.76917822
147Ankle contracture (HP:0006466)1.73717106
148Abnormality of the middle phalanges of the hand (HP:0009833)1.73125862
149Preauricular pit (HP:0004467)1.73067612
150Periauricular skin pits (HP:0100277)1.73067612
151Renal agenesis (HP:0000104)1.72662679
152Partial duplication of thumb phalanx (HP:0009944)1.72503396
153Carpal synostosis (HP:0009702)1.72429411
154Abnormality of the carotid arteries (HP:0005344)1.71623724
155Choanal stenosis (HP:0000452)1.71543040
156Symphalangism affecting the phalanges of the hand (HP:0009773)1.71531809
157Abnormality of the dental pulp (HP:0006479)1.71396312
158Abnormality of the aortic arch (HP:0012303)1.70432354
159Reticulocytopenia (HP:0001896)1.70181824
160Short thumb (HP:0009778)1.69635994
161Fused cervical vertebrae (HP:0002949)1.68565707
162Advanced eruption of teeth (HP:0006288)1.66870303
163Bell-shaped thorax (HP:0001591)1.64188935
164Germ cell neoplasia (HP:0100728)1.64175795
165Congenital ichthyosiform erythroderma (HP:0007431)1.63737453
166Abnormal foot bone ossification (HP:0010675)1.63563727
167Diaphragmatic weakness (HP:0009113)1.62984115
168Deep philtrum (HP:0002002)1.62355617
169Coarctation of aorta (HP:0001680)1.61865973
170Pterygium (HP:0001059)1.60961073
171Facial cleft (HP:0002006)1.60828099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.31637254
2EPHB24.13711769
3STK38L3.43091862
4LATS13.19082846
5LATS23.07387171
6TRIB33.01646015
7PKN22.74542471
8PBK2.65000336
9NME22.59424323
10SMG12.58269788
11AKT32.55855902
12MKNK12.40751034
13SRPK12.35682820
14MKNK22.32060775
15PLK42.30185454
16SCYL22.27225478
17BRD42.24116287
18EEF2K2.08943956
19CDK122.06548232
20TRIM282.06185985
21VRK22.00237476
22ZAK1.97046122
23FER1.82998192
24MST41.67070372
25FGFR11.65180822
26LIMK11.55466631
27PRPF4B1.53438141
28MAP3K121.53069910
29BLK1.50763306
30TAF11.49462085
31CDK71.48388057
32STK31.42435431
33SIK31.42262075
34FGFR21.41511750
35BCR1.40167666
36ICK1.38285625
37TTK1.35160935
38RPS6KB21.35144942
39TESK11.34958495
40CASK1.30550103
41DDR21.27322596
42NME11.26977885
43MELK1.26572469
44TAOK21.16230935
45ERBB31.15506891
46PAK41.15416105
47MUSK1.13948071
48CHEK21.13400585
49CDC71.13036400
50ACVR1B1.10899809
51TLK11.10102357
52CDK81.09403381
53YES11.09243791
54BUB11.07771400
55EIF2AK31.07737339
56ILK1.07319804
57LRRK21.06819476
58ATR1.05267584
59TGFBR11.03092328
60BMPR1B0.99981560
61PLK30.98481642
62ERBB20.98351471
63NUAK10.98290395
64PIK3CA0.98175331
65MAP2K20.97061507
66MAPKAPK30.96780462
67BRSK20.94869134
68TTN0.94082113
69EIF2AK10.91778617
70DMPK0.91364599
71PLK20.88613370
72PIK3CG0.85762119
73NEK10.84438959
74CDK30.84223902
75TSSK60.84004095
76BRSK10.82786225
77MAP2K10.80656606
78CDK60.79760933
79MAP3K90.79608704
80PAK20.78377210
81TESK20.77626871
82ROCK10.76952919
83STK160.76317963
84KSR10.75606241
85DYRK20.75576341
86PTK20.75334619
87SIK10.73830777
88EPHA30.72567243
89CHEK10.71038479
90RPS6KA40.70601283
91BRAF0.69873815
92EIF2AK20.68264607
93STK390.67691689
94AURKB0.67313199
95STK380.66830686
96PLK10.64572974
97PTK60.63608044
98CDK40.62531683
99CDC42BPA0.61166799
100PAK30.60802959
101ATM0.59869772
102NEK20.59747179
103MST1R0.58648934
104STK240.58455957
105PNCK0.58147266
106ADRBK20.56935714
107DYRK30.56309461
108PDGFRA0.55710640
109MET0.55118798
110STK40.54063868
111MAP3K80.53304084
112NLK0.53161738
113CDK90.51751673
114AURKA0.51545693
115STK100.50129230
116PASK0.49962099
117WEE10.49910743
118MYLK0.49553874
119ROCK20.48931750
120CLK10.48081328
121PIM20.47644739
122MAP3K100.46139575
123MTOR0.45953049
124MAP3K110.45918576
125PAK10.45840740
126CDK10.44579858
127RPS6KB10.41323564
128AKT10.41227361
129IRAK30.40777210
130VRK10.38982993
131NEK60.37338075
132RIPK10.36356099
133ARAF0.35876190
134PRKCI0.34705874
135CAMK2G0.34503310
136TRPM70.34466255
137DAPK30.34422408
138AKT20.33713468
139RPS6KL10.33324433
140RPS6KC10.33324433
141MAP3K30.33277705
142CDK20.33006689
143CSNK1A1L0.32222095
144CSNK1E0.30583800

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.57780082
2Hedgehog signaling pathway_Homo sapiens_hsa043403.60592664
3Hippo signaling pathway_Homo sapiens_hsa043903.08287780
4Wnt signaling pathway_Homo sapiens_hsa043102.31433644
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.26199626
6TGF-beta signaling pathway_Homo sapiens_hsa043502.22338083
7Spliceosome_Homo sapiens_hsa030402.14185474
8Adherens junction_Homo sapiens_hsa045202.05851742
9Cell cycle_Homo sapiens_hsa041102.01718404
10Axon guidance_Homo sapiens_hsa043601.98648643
11Fanconi anemia pathway_Homo sapiens_hsa034601.81549194
12p53 signaling pathway_Homo sapiens_hsa041151.79994492
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78246399
14Sulfur relay system_Homo sapiens_hsa041221.77129698
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76777061
16MicroRNAs in cancer_Homo sapiens_hsa052061.73859989
17ECM-receptor interaction_Homo sapiens_hsa045121.71441213
18Proteoglycans in cancer_Homo sapiens_hsa052051.66489274
19Melanoma_Homo sapiens_hsa052181.56428492
20Melanogenesis_Homo sapiens_hsa049161.54255814
21DNA replication_Homo sapiens_hsa030301.53696499
22RNA transport_Homo sapiens_hsa030131.53543115
23Homologous recombination_Homo sapiens_hsa034401.52610497
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52379375
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50459865
26Mismatch repair_Homo sapiens_hsa034301.48210893
27Notch signaling pathway_Homo sapiens_hsa043301.47010215
28RNA polymerase_Homo sapiens_hsa030201.46509524
29Bladder cancer_Homo sapiens_hsa052191.45367365
30Pathways in cancer_Homo sapiens_hsa052001.37178582
31Tight junction_Homo sapiens_hsa045301.36190140
32mRNA surveillance pathway_Homo sapiens_hsa030151.35234098
33Basal transcription factors_Homo sapiens_hsa030221.33505546
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30171062
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28315819
36Biosynthesis of amino acids_Homo sapiens_hsa012301.28232358
37Folate biosynthesis_Homo sapiens_hsa007901.27557568
38Ribosome_Homo sapiens_hsa030101.23774980
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.22831176
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22099515
41Vibrio cholerae infection_Homo sapiens_hsa051101.21363714
42Focal adhesion_Homo sapiens_hsa045101.20201403
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19714370
44N-Glycan biosynthesis_Homo sapiens_hsa005101.19617775
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19296646
46Base excision repair_Homo sapiens_hsa034101.18651325
47Small cell lung cancer_Homo sapiens_hsa052221.17366628
48* HTLV-I infection_Homo sapiens_hsa051661.17202457
49Proteasome_Homo sapiens_hsa030501.11027745
50Non-homologous end-joining_Homo sapiens_hsa034501.10980990
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.10163471
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09220124
53Fatty acid elongation_Homo sapiens_hsa000621.09023175
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08522546
55Selenocompound metabolism_Homo sapiens_hsa004501.07423025
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01787544
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01729645
58Pentose phosphate pathway_Homo sapiens_hsa000300.99617101
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99117967
60Rap1 signaling pathway_Homo sapiens_hsa040150.99084484
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97433650
62Sulfur metabolism_Homo sapiens_hsa009200.95685726
63Alcoholism_Homo sapiens_hsa050340.93304059
64Prostate cancer_Homo sapiens_hsa052150.92418794
65Nucleotide excision repair_Homo sapiens_hsa034200.89891890
66Pyruvate metabolism_Homo sapiens_hsa006200.86326277
67RNA degradation_Homo sapiens_hsa030180.86013567
68Arginine and proline metabolism_Homo sapiens_hsa003300.81818463
69Dilated cardiomyopathy_Homo sapiens_hsa054140.81753886
70Colorectal cancer_Homo sapiens_hsa052100.81542821
71Vitamin B6 metabolism_Homo sapiens_hsa007500.81155130
72Carbon metabolism_Homo sapiens_hsa012000.80860398
73Viral myocarditis_Homo sapiens_hsa054160.79917770
74Endometrial cancer_Homo sapiens_hsa052130.79594910
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79314227
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79017312
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71818749
78Systemic lupus erythematosus_Homo sapiens_hsa053220.71775728
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71708673
80Ras signaling pathway_Homo sapiens_hsa040140.71005133
81Pyrimidine metabolism_Homo sapiens_hsa002400.70754135
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70077156
83Thyroid cancer_Homo sapiens_hsa052160.67340000
84AMPK signaling pathway_Homo sapiens_hsa041520.66611542
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.62696185
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61748189
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60184072
88Arachidonic acid metabolism_Homo sapiens_hsa005900.60084969
89Shigellosis_Homo sapiens_hsa051310.58512782
90Huntingtons disease_Homo sapiens_hsa050160.58498636
91One carbon pool by folate_Homo sapiens_hsa006700.57832748
92Oocyte meiosis_Homo sapiens_hsa041140.57656813
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57291633
94Galactose metabolism_Homo sapiens_hsa000520.57088076
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56976482
96Arginine biosynthesis_Homo sapiens_hsa002200.56578320
97Epstein-Barr virus infection_Homo sapiens_hsa051690.56408273
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56395372
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55237214
100Steroid biosynthesis_Homo sapiens_hsa001000.54799470
101Amoebiasis_Homo sapiens_hsa051460.54316968
102Nicotine addiction_Homo sapiens_hsa050330.52024341
103Herpes simplex infection_Homo sapiens_hsa051680.50612637
104Glutathione metabolism_Homo sapiens_hsa004800.50343580
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49346448
106ErbB signaling pathway_Homo sapiens_hsa040120.45889169
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45401149
108MAPK signaling pathway_Homo sapiens_hsa040100.44694502
109Oxidative phosphorylation_Homo sapiens_hsa001900.44580108
110Viral carcinogenesis_Homo sapiens_hsa052030.43999863
111Inositol phosphate metabolism_Homo sapiens_hsa005620.43671004
112FoxO signaling pathway_Homo sapiens_hsa040680.43449908
113Chronic myeloid leukemia_Homo sapiens_hsa052200.43318920
114Mineral absorption_Homo sapiens_hsa049780.41709063
115Long-term depression_Homo sapiens_hsa047300.40931449
116Vitamin digestion and absorption_Homo sapiens_hsa049770.39446040
117Collecting duct acid secretion_Homo sapiens_hsa049660.38971951
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37754531
119Purine metabolism_Homo sapiens_hsa002300.36866270
120Autoimmune thyroid disease_Homo sapiens_hsa053200.36835472
121Insulin signaling pathway_Homo sapiens_hsa049100.36744646
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35474556
123Renal cell carcinoma_Homo sapiens_hsa052110.35188468
124Protein digestion and absorption_Homo sapiens_hsa049740.34863821
125Malaria_Homo sapiens_hsa051440.34668134
126Serotonergic synapse_Homo sapiens_hsa047260.33763424
127Lysine degradation_Homo sapiens_hsa003100.33410726
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31977765
129Metabolic pathways_Homo sapiens_hsa011000.31828563
130mTOR signaling pathway_Homo sapiens_hsa041500.31701880
131Glioma_Homo sapiens_hsa052140.29603786
132Phototransduction_Homo sapiens_hsa047440.29368417
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.28115800
134Non-small cell lung cancer_Homo sapiens_hsa052230.28004085
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27293118
136Sphingolipid metabolism_Homo sapiens_hsa006000.26980866
137Allograft rejection_Homo sapiens_hsa053300.26581993
138Taste transduction_Homo sapiens_hsa047420.26278242
139Pancreatic cancer_Homo sapiens_hsa052120.25361421
140Ether lipid metabolism_Homo sapiens_hsa005650.23950972
141Apoptosis_Homo sapiens_hsa042100.23530308

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