MT-ATP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.11569353
2oxidative phosphorylation (GO:0006119)4.90467550
3DNA deamination (GO:0045006)4.69036516
4synaptic vesicle maturation (GO:0016188)4.21507456
5aerobic respiration (GO:0009060)4.07597022
6NADH metabolic process (GO:0006734)4.05008697
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.03797781
8CENP-A containing nucleosome assembly (GO:0034080)4.02546669
9respiratory chain complex IV assembly (GO:0008535)3.99574979
10potassium ion homeostasis (GO:0055075)3.94761966
11chromatin remodeling at centromere (GO:0031055)3.92038120
12purine nucleobase biosynthetic process (GO:0009113)3.83266353
13positive regulation of synapse maturation (GO:0090129)3.82870421
14locomotory exploration behavior (GO:0035641)3.78694984
15tricarboxylic acid cycle (GO:0006099)3.75808373
16telomere maintenance via semi-conservative replication (GO:0032201)3.67567044
17mitotic G1 DNA damage checkpoint (GO:0031571)3.62205515
18maturation of SSU-rRNA (GO:0030490)3.61662964
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54964485
20DNA replication-independent nucleosome organization (GO:0034724)3.53411195
21DNA replication-independent nucleosome assembly (GO:0006336)3.53411195
22cytochrome complex assembly (GO:0017004)3.52021059
23creatine metabolic process (GO:0006600)3.48901697
24pseudouridine synthesis (GO:0001522)3.43792697
25nucleobase biosynthetic process (GO:0046112)3.29149359
26membrane repolarization (GO:0086009)3.28932158
27succinate metabolic process (GO:0006105)3.28625835
28kinetochore organization (GO:0051383)3.26120687
29kinetochore assembly (GO:0051382)3.23166025
30histone exchange (GO:0043486)3.21155627
31mitotic metaphase plate congression (GO:0007080)3.20548824
32telomere maintenance via recombination (GO:0000722)3.20130722
33response to parathyroid hormone (GO:0071107)3.19838001
34deoxyribose phosphate biosynthetic process (GO:0046385)3.17885967
352-deoxyribonucleotide biosynthetic process (GO:0009265)3.17885967
36synaptic vesicle exocytosis (GO:0016079)3.17120770
37axon ensheathment in central nervous system (GO:0032291)3.16295950
38central nervous system myelination (GO:0022010)3.16295950
39potassium ion import (GO:0010107)3.13915646
40DNA strand elongation involved in DNA replication (GO:0006271)3.13657578
41DNA replication checkpoint (GO:0000076)3.10547050
42regulation of synapse structural plasticity (GO:0051823)3.10422065
43membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.09747732
44lysine catabolic process (GO:0006554)3.07604281
45lysine metabolic process (GO:0006553)3.07604281
46membrane repolarization during action potential (GO:0086011)3.07356148
47positive regulation of respiratory burst (GO:0060267)3.05107557
48DNA strand elongation (GO:0022616)3.03388353
49regulation of synapse maturation (GO:0090128)3.00754706
50DNA replication initiation (GO:0006270)3.00498598
51ribosome biogenesis (GO:0042254)2.98081480
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97454114
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95478257
54regulation of translational termination (GO:0006449)2.93706515
55regulation of oxidative phosphorylation (GO:0002082)2.93151562
56neuronal ion channel clustering (GO:0045161)2.93073276
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92176364
58sodium ion export (GO:0071436)2.91410489
59regulation of translational fidelity (GO:0006450)2.91025617
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90546137
61endosome to melanosome transport (GO:0035646)2.89332888
62endosome to pigment granule transport (GO:0043485)2.89332888
63mitotic recombination (GO:0006312)2.88789212
64cellular respiration (GO:0045333)2.86775344
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86501040
66cellular sodium ion homeostasis (GO:0006883)2.83231493
67translational elongation (GO:0006414)2.83038056
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82232558
69metallo-sulfur cluster assembly (GO:0031163)2.81840415
70iron-sulfur cluster assembly (GO:0016226)2.81840415
71regulation of synaptic vesicle transport (GO:1902803)2.81656723
72regulation of nuclear cell cycle DNA replication (GO:0033262)2.80568882
73viral transcription (GO:0019083)2.80387328
74nucleoside diphosphate biosynthetic process (GO:0009133)2.80145991
75cerebellar granule cell differentiation (GO:0021707)2.78977776
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78463023
77telomere maintenance via telomere lengthening (GO:0010833)2.78329282
78translational termination (GO:0006415)2.77952547
79regulation of heart rate by cardiac conduction (GO:0086091)2.77473816
80necroptotic process (GO:0070266)2.75923165
81oxaloacetate metabolic process (GO:0006107)2.74688871
82metaphase plate congression (GO:0051310)2.74409216
83* respiratory electron transport chain (GO:0022904)2.74092668
84mitotic G1/S transition checkpoint (GO:0044819)2.71927974
85G1 DNA damage checkpoint (GO:0044783)2.71683579
86CDP-diacylglycerol metabolic process (GO:0046341)2.71083828
87proline biosynthetic process (GO:0006561)2.70436445
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69198586
89rRNA modification (GO:0000154)2.69117404
90cell communication involved in cardiac conduction (GO:0086065)2.67255554
91activation of protein kinase A activity (GO:0034199)2.67231394
92* electron transport chain (GO:0022900)2.66859899
93heterochromatin organization (GO:0070828)2.65271400
94folic acid metabolic process (GO:0046655)2.65015133
95antigen processing and presentation via MHC class Ib (GO:0002475)2.64988208
96regulation of protein dephosphorylation (GO:0035304)2.64029744
97IMP biosynthetic process (GO:0006188)2.63942966
98tricarboxylic acid metabolic process (GO:0072350)2.62881427
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.61415882
100cardiac conduction (GO:0061337)2.60138139
101neuromuscular process controlling posture (GO:0050884)2.59841334
102lung epithelium development (GO:0060428)2.57799634
103proline metabolic process (GO:0006560)2.57018047
104muscle cell fate commitment (GO:0042693)2.55734194
105attachment of spindle microtubules to kinetochore (GO:0008608)2.55343187
106regulation of synaptic vesicle exocytosis (GO:2000300)2.53075162
107dopamine receptor signaling pathway (GO:0007212)2.53051792
108neurotransmitter secretion (GO:0007269)2.52888508
109body morphogenesis (GO:0010171)2.52512660
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51956965
111glutamate secretion (GO:0014047)2.51789885
112potassium ion export (GO:0071435)2.51600140
113cellular potassium ion homeostasis (GO:0030007)2.51388771
114positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51232129
115positive regulation of sodium ion transport (GO:0010765)2.50574340
116peptidyl-lysine dimethylation (GO:0018027)2.50275730
117regulation of early endosome to late endosome transport (GO:2000641)2.49940068
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.48192789
119ribonucleoprotein complex biogenesis (GO:0022613)2.47953473
120cell communication by electrical coupling (GO:0010644)2.47821495
121protein localization to kinetochore (GO:0034501)2.47561347
122positive regulation of neurotransmitter secretion (GO:0001956)2.47440872
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47226727
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45799877
125negative regulation of RNA splicing (GO:0033119)2.45659271
126regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45105662
1272-oxoglutarate metabolic process (GO:0006103)2.44851802
128neuronal action potential propagation (GO:0019227)2.44426978
129deoxyribonucleotide biosynthetic process (GO:0009263)2.44002277
130SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.43863728
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43855115
132vitamin transmembrane transport (GO:0035461)2.42845503
133protein retention in ER lumen (GO:0006621)2.42721567
134mitochondrion transport along microtubule (GO:0047497)2.41321595
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.41321595
136mitotic chromosome condensation (GO:0007076)2.40831963
137response to ischemia (GO:0002931)2.40746716
138regulation of neuronal synaptic plasticity (GO:0048168)2.39409350
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.39306160
140regulation of female receptivity (GO:0045924)2.39089432
141IMP metabolic process (GO:0046040)2.37373970
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.36736629
143cerebellar Purkinje cell layer development (GO:0021680)2.36672677
144L-serine metabolic process (GO:0006563)2.34721425
145negative regulation of macroautophagy (GO:0016242)2.34053500
146maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32565954
147positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30935624
148genetic imprinting (GO:0071514)2.30659162
149CDP-diacylglycerol biosynthetic process (GO:0016024)2.29274486
150sodium ion homeostasis (GO:0055078)2.29258813
151regulation of membrane repolarization (GO:0060306)2.26713897
152cellular response to nitric oxide (GO:0071732)2.23081980
153positive regulation of dendritic spine development (GO:0060999)2.22716629
154regulation of mitotic spindle organization (GO:0060236)2.19143172
155cell-cell junction maintenance (GO:0045217)2.16755849
156response to histamine (GO:0034776)2.15865994
157neurotransmitter transport (GO:0006836)2.15797479
158serine family amino acid biosynthetic process (GO:0009070)2.15751036
159neuromuscular process controlling balance (GO:0050885)2.15402687
160positive regulation of cellular amine metabolic process (GO:0033240)2.12791494
161regulation of cellular respiration (GO:0043457)2.11485384
162positive regulation of gene expression, epigenetic (GO:0045815)2.11436288
163layer formation in cerebral cortex (GO:0021819)2.10771862
164negative regulation of telomerase activity (GO:0051974)2.10619104
165regulation of voltage-gated calcium channel activity (GO:1901385)2.10111113
166regulation of bile acid biosynthetic process (GO:0070857)2.10057126
167glutathione biosynthetic process (GO:0006750)2.09510662
168regulation of glutamate receptor signaling pathway (GO:1900449)2.08989853
169gluconeogenesis (GO:0006094)2.07118440
170female mating behavior (GO:0060180)2.04385291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41024932
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.27822782
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.85738448
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.56114797
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66551326
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55602050
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.53068173
8LXR_22292898_ChIP-Seq_THP-1_Human2.50608856
9GATA1_22025678_ChIP-Seq_K562_Human2.45858655
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43909453
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42596956
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41459023
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38820880
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38152565
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.36275852
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36226487
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36051594
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33453558
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30332847
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.28729550
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17530103
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.15704255
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.14351338
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10430417
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10257578
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.10026161
27MYC_22102868_ChIP-Seq_BL_Human2.06040800
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04638727
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02596536
30VDR_23849224_ChIP-Seq_CD4+_Human1.96598604
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.94312208
32XRN2_22483619_ChIP-Seq_HELA_Human1.93456010
33AR_21909140_ChIP-Seq_LNCAP_Human1.92314341
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92200228
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.92101801
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.91229424
37RACK7_27058665_Chip-Seq_MCF-7_Human1.89368166
38KDM2B_26808549_Chip-Seq_K562_Human1.87042690
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86441842
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86052680
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85726470
42ZNF263_19887448_ChIP-Seq_K562_Human1.83713473
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82329429
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81896943
45SCL_19346495_ChIP-Seq_HPC-7_Human1.81299620
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.80254626
47GABP_19822575_ChIP-Seq_HepG2_Human1.80224044
48CTCF_27219007_Chip-Seq_Bcells_Human1.78666626
49CIITA_25753668_ChIP-Seq_RAJI_Human1.78489322
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77505714
51FOXP3_21729870_ChIP-Seq_TREG_Human1.75322211
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69365824
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67583562
54SMC4_20622854_ChIP-Seq_HELA_Human1.65686746
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62983581
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.57747135
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55285614
58CREB1_26743006_Chip-Seq_LNCaP_Human1.54472257
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54407412
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54167307
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54086213
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52022504
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.51654350
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48269048
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48198486
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47204445
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46911727
68DCP1A_22483619_ChIP-Seq_HELA_Human1.46730704
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45280303
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43708450
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41087746
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.41073337
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41043862
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40863792
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38819349
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38458012
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.38281592
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34718642
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34326923
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32607819
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31648429
82SA1_27219007_Chip-Seq_Bcells_Human1.29889509
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29844955
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29273468
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29134551
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28493417
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.28394261
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27849760
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27527355
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.26415338
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.26081917
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24936089
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24516248
94TTF2_22483619_ChIP-Seq_HELA_Human1.24349725
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.24026577
96KDM5A_27292631_Chip-Seq_BREAST_Human1.23363616
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22145285
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21791992
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20428046
100KDM2B_26808549_Chip-Seq_DND41_Human1.19611858
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18788604
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.17670363
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17531558
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17321040
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16713848
106POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16576374
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16255971
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16196909
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15810024
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15093802
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14390424
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14390424
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14352207
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.13434991
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13222952
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12490178
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.11966263
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11731652
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11599895
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11393761
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11028809
122RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10755607
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10683754
124SPI1_23547873_ChIP-Seq_NB4_Human1.10619222
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10189121
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09039039
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07603774
128CTCF_20526341_ChIP-Seq_ESCs_Human1.07309656
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07091108
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.06288024
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06266629
132TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04244026
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.04208894
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03116517
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02981308
136RARB_24833708_ChIP-Seq_LIVER_Mouse1.02726513
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01633496
138TCF7_22412390_ChIP-Seq_EML_Mouse1.01446932
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00179455
140ETS1_21867929_ChIP-Seq_TH2_Mouse0.99516162
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.99448428
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99010600
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98701585
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98595242
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98567770
146FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98523077
147BCOR_27268052_Chip-Seq_Bcells_Human0.98341833
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.98124404
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98117257
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98083584
151OCT4_19829295_ChIP-Seq_ESCs_Human0.97039310
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96966641
153REST_21632747_ChIP-Seq_MESCs_Mouse0.96176673
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96126892
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.96043868
156RARB_27405468_Chip-Seq_BRAIN_Mouse0.95196894
157TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95086499
158RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94291905
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93319327
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92619767
161NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92002236
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91626638
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91020826
164BCL6_27268052_Chip-Seq_Bcells_Human0.90765482
165CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90249803
166P68_20966046_ChIP-Seq_HELA_Human0.90167872
167VDR_21846776_ChIP-Seq_THP-1_Human0.89685397
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88174414
169CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88075106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.60768052
2MP0004147_increased_porphyrin_level3.12623984
3MP0003693_abnormal_embryo_hatching3.12038719
4MP0002396_abnormal_hematopoietic_system3.06646807
5MP0006036_abnormal_mitochondrial_physio3.05803950
6MP0000678_abnormal_parathyroid_gland2.91179718
7MP0002822_catalepsy2.81296334
8MP0004043_abnormal_pH_regulation2.62720001
9MP0004215_abnormal_myocardial_fiber2.60754988
10MP0005423_abnormal_somatic_nervous2.49518684
11MP0001545_abnormal_hematopoietic_system2.49405219
12MP0005397_hematopoietic_system_phenotyp2.49405219
13MP0005670_abnormal_white_adipose2.45805102
14MP0009780_abnormal_chondrocyte_physiolo2.31264136
15MP0002249_abnormal_larynx_morphology2.27221952
16MP0003646_muscle_fatigue2.24168224
17MP0004270_analgesia2.20806437
18MP0004957_abnormal_blastocyst_morpholog2.15666179
19MP0003123_paternal_imprinting2.14261780
20MP0010094_abnormal_chromosome_stability2.03590904
21MP0003879_abnormal_hair_cell1.97478169
22MP0003111_abnormal_nucleus_morphology1.96583539
23MP0003635_abnormal_synaptic_transmissio1.96139158
24MP0006054_spinal_hemorrhage1.86705209
25MP0004808_abnormal_hematopoietic_stem1.86398462
26MP0003656_abnormal_erythrocyte_physiolo1.85302854
27MP0001502_abnormal_circadian_rhythm1.76666987
28MP0003880_abnormal_central_pattern1.71951809
29MP0008569_lethality_at_weaning1.65299998
30MP0000566_synostosis1.63925329
31MP0008872_abnormal_physiological_respon1.63565166
32MP0003077_abnormal_cell_cycle1.57741973
33MP0008877_abnormal_DNA_methylation1.53518729
34MP0005085_abnormal_gallbladder_physiolo1.52830475
35MP0001853_heart_inflammation1.50891509
36MP0004084_abnormal_cardiac_muscle1.49690008
37MP0006035_abnormal_mitochondrial_morpho1.49466540
38MP0004019_abnormal_vitamin_homeostasis1.47856971
39MP0005666_abnormal_adipose_tissue1.45653131
40MP0009672_abnormal_birth_weight1.41965135
41MP0001188_hyperpigmentation1.41567038
42MP0002734_abnormal_mechanical_nocicepti1.40732639
43MP0002139_abnormal_hepatobiliary_system1.40060897
44MP0002909_abnormal_adrenal_gland1.39891454
45MP0009745_abnormal_behavioral_response1.39486723
46MP0004185_abnormal_adipocyte_glucose1.39344776
47MP0005584_abnormal_enzyme/coenzyme_acti1.37985031
48MP0002733_abnormal_thermal_nociception1.37406467
49MP0002572_abnormal_emotion/affect_behav1.33679994
50MP0005167_abnormal_blood-brain_barrier1.31659369
51MP0008961_abnormal_basal_metabolism1.30737940
52MP0003866_abnormal_defecation1.29948285
53MP0009046_muscle_twitch1.29591250
54MP0000751_myopathy1.28884053
55MP0008007_abnormal_cellular_replicative1.26059769
56MP0005360_urolithiasis1.24816773
57MP0001970_abnormal_pain_threshold1.24105532
58MP0003806_abnormal_nucleotide_metabolis1.20804921
59MP0008058_abnormal_DNA_repair1.20730010
60MP0003186_abnormal_redox_activity1.18843513
61MP0000490_abnormal_crypts_of1.18779832
62MP0001348_abnormal_lacrimal_gland1.17743129
63MP0005409_darkened_coat_color1.17254829
64MP0003075_altered_response_to1.16449024
65MP0001501_abnormal_sleep_pattern1.15591805
66MP0005535_abnormal_body_temperature1.15568552
67MP0002063_abnormal_learning/memory/cond1.13960760
68MP0002557_abnormal_social/conspecific_i1.12477041
69MP0005332_abnormal_amino_acid1.11558360
70MP0003787_abnormal_imprinting1.10717735
71MP0005174_abnormal_tail_pigmentation1.10509565
72MP0005636_abnormal_mineral_homeostasis1.09089407
73MP0003122_maternal_imprinting1.07169400
74MP0005377_hearing/vestibular/ear_phenot1.06595661
75MP0003878_abnormal_ear_physiology1.06595661
76MP0005375_adipose_tissue_phenotype1.06157436
77MP0002095_abnormal_skin_pigmentation1.05929791
78MP0001440_abnormal_grooming_behavior1.05433759
79MP0001968_abnormal_touch/_nociception1.04748395
80MP0003121_genomic_imprinting1.04577929
81MP0003283_abnormal_digestive_organ1.04352210
82MP0002796_impaired_skin_barrier1.03678312
83MP0005330_cardiomyopathy1.03250792
84MP0004130_abnormal_muscle_cell1.02197262
85MP0002089_abnormal_postnatal_growth/wei1.01278613
86MP0008775_abnormal_heart_ventricle1.00156907
87MP0005319_abnormal_enzyme/_coenzyme0.99584421
88MP0003763_abnormal_thymus_physiology0.99512918
89MP0005646_abnormal_pituitary_gland0.98853795
90MP0004885_abnormal_endolymph0.97687051
91MP0002272_abnormal_nervous_system0.97450244
92MP0010234_abnormal_vibrissa_follicle0.95413492
93MP0002006_tumorigenesis0.95127101
94MP0008932_abnormal_embryonic_tissue0.94797119
95MP0002066_abnormal_motor_capabilities/c0.94697004
96MP0005187_abnormal_penis_morphology0.92136574
97MP0010030_abnormal_orbit_morphology0.90660487
98MP0001764_abnormal_homeostasis0.90607039
99MP0004742_abnormal_vestibular_system0.89820197
100MP0002877_abnormal_melanocyte_morpholog0.89447602
101MP0009379_abnormal_foot_pigmentation0.88367300
102MP0002064_seizures0.88043348
103MP0001485_abnormal_pinna_reflex0.87294206
104MP0002398_abnormal_bone_marrow0.87021631
105MP0000003_abnormal_adipose_tissue0.85803678
106MP0003567_abnormal_fetal_cardiomyocyte0.85132077
107MP0005671_abnormal_response_to0.83356562
108MP0004484_altered_response_of0.82669392
109MP0000313_abnormal_cell_death0.81940864
110MP0001765_abnormal_ion_homeostasis0.81144996
111MP0010630_abnormal_cardiac_muscle0.80502832
112MP0002166_altered_tumor_susceptibility0.80403348
113MP0003300_gastrointestinal_ulcer0.80349067
114MP0001756_abnormal_urination0.80216281
115MP0005464_abnormal_platelet_physiology0.80043554
116MP0006138_congestive_heart_failure0.79775166
117MP0003938_abnormal_ear_development0.79662512
118MP0003786_premature_aging0.79507383
119MP0002184_abnormal_innervation0.79181252
120MP0003943_abnormal_hepatobiliary_system0.78304397
121MP0009643_abnormal_urine_homeostasis0.77494745
122MP0010329_abnormal_lipoprotein_level0.77177078
123MP0000955_abnormal_spinal_cord0.76026431
124MP0003942_abnormal_urinary_system0.75777475
125MP0000579_abnormal_nail_morphology0.74301482
126MP0002735_abnormal_chemical_nociception0.73894182
127MP0004036_abnormal_muscle_relaxation0.73876900
128MP0001873_stomach_inflammation0.73840271
129MP0002210_abnormal_sex_determination0.73686345
130MP0002234_abnormal_pharynx_morphology0.73672379
131MP0006292_abnormal_olfactory_placode0.73595421
132MP0001731_abnormal_postnatal_growth0.73318193
133MP0002019_abnormal_tumor_incidence0.71673491
134MP0005448_abnormal_energy_balance0.71441826
135MP0001984_abnormal_olfaction0.70780963
136MP0000462_abnormal_digestive_system0.70268144
137MP0005385_cardiovascular_system_phenoty0.70238495
138MP0001544_abnormal_cardiovascular_syste0.70238495
139MP0002876_abnormal_thyroid_physiology0.70062788
140MP0002229_neurodegeneration0.70052432
141MP0008875_abnormal_xenobiotic_pharmacok0.69915664
142MP0005166_decreased_susceptibility_to0.69186420
143MP0005084_abnormal_gallbladder_morpholo0.69152684
144MP0000747_muscle_weakness0.69103740
145MP0002722_abnormal_immune_system0.69071198
146MP0010155_abnormal_intestine_physiology0.68994113
147MP0002152_abnormal_brain_morphology0.68971806
148MP0005365_abnormal_bile_salt0.68553440
149MP0002882_abnormal_neuron_morphology0.67931872
150MP0005452_abnormal_adipose_tissue0.67517613
151MP0001119_abnormal_female_reproductive0.67372848
152MP0001486_abnormal_startle_reflex0.67317199
153MP0001730_embryonic_growth_arrest0.66921397
154MP0002970_abnormal_white_adipose0.66210271
155MP0004264_abnormal_extraembryonic_tissu0.65744842
156MP0004811_abnormal_neuron_physiology0.64939281
157MP0002971_abnormal_brown_adipose0.64153164

Predicted human phenotypes

RankGene SetZ-score
1Hyperthyroidism (HP:0000836)4.77526576
2Truncus arteriosus (HP:0001660)4.71492478
3Ventricular fibrillation (HP:0001663)4.48863896
4Abnormal number of erythroid precursors (HP:0012131)4.28306865
5Aplastic anemia (HP:0001915)4.28057243
6Congenital malformation of the right heart (HP:0011723)3.88737324
7Double outlet right ventricle (HP:0001719)3.88737324
8Abnormality of cells of the erythroid lineage (HP:0012130)3.86971052
9Myokymia (HP:0002411)3.80546113
10Obstructive sleep apnea (HP:0002870)3.75722561
11Abnormality of the aortic arch (HP:0012303)3.54083617
12Papilledema (HP:0001085)3.49974700
13Gout (HP:0001997)3.45380796
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.31606585
15Hepatic necrosis (HP:0002605)3.30384459
16Cerebral hypomyelination (HP:0006808)3.25303662
17Visual hallucinations (HP:0002367)3.22766348
18Thrombocytosis (HP:0001894)3.21507870
19Bundle branch block (HP:0011710)3.18460045
20Abnormality of cochlea (HP:0000375)3.08747742
21Oral leukoplakia (HP:0002745)3.04411300
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03797203
23Abnormality of alanine metabolism (HP:0010916)3.03797203
24Hyperalaninemia (HP:0003348)3.03797203
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97567244
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97567244
27Generalized aminoaciduria (HP:0002909)2.96146143
28Hepatocellular necrosis (HP:0001404)2.87268975
29Hyperphosphatemia (HP:0002905)2.82917032
30Increased muscle lipid content (HP:0009058)2.81085900
31Birth length less than 3rd percentile (HP:0003561)2.76600584
32Annular pancreas (HP:0001734)2.75564854
33Tetraplegia (HP:0002445)2.71916169
34Increased intramyocellular lipid droplets (HP:0012240)2.70197678
35Focal motor seizures (HP:0011153)2.64748661
36Colon cancer (HP:0003003)2.62478220
37Stridor (HP:0010307)2.61246515
38Poor eye contact (HP:0000817)2.59552604
39Morphological abnormality of the inner ear (HP:0011390)2.58687971
40Delayed CNS myelination (HP:0002188)2.56187001
41Enlarged penis (HP:0000040)2.53450103
42Hyperglycinuria (HP:0003108)2.52559559
43Atrioventricular block (HP:0001678)2.50441319
44Abnormal ventriculo-arterial connection (HP:0011563)2.48312926
45Transposition of the great arteries (HP:0001669)2.48312926
46Abnormal connection of the cardiac segments (HP:0011545)2.48312926
47Atelectasis (HP:0100750)2.46498204
48Nausea (HP:0002018)2.41115128
49Heart block (HP:0012722)2.37329078
50Progressive muscle weakness (HP:0003323)2.35574890
51Abnormality of fatty-acid metabolism (HP:0004359)2.35363775
52Hypoplastic left heart (HP:0004383)2.34889122
53Hypoglycemic coma (HP:0001325)2.32561115
54Seborrheic dermatitis (HP:0001051)2.32060317
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31901919
56Dicarboxylic aciduria (HP:0003215)2.31901919
57Depression (HP:0000716)2.30221321
58Hyperglycinemia (HP:0002154)2.29168616
59Hyperparathyroidism (HP:0000843)2.28351336
60Abnormality of magnesium homeostasis (HP:0004921)2.28068256
61Acute lymphatic leukemia (HP:0006721)2.26578291
62Epileptic encephalopathy (HP:0200134)2.25925380
63Lactic acidosis (HP:0003128)2.25687273
64Insomnia (HP:0100785)2.25271471
65Renal salt wasting (HP:0000127)2.25191206
66Type 2 muscle fiber atrophy (HP:0003554)2.22944374
67Impaired social interactions (HP:0000735)2.22150353
68Abnormal social behavior (HP:0012433)2.22150353
69Abnormal spermatogenesis (HP:0008669)2.17610254
70Abnormal EKG (HP:0003115)2.16741933
71Periauricular skin pits (HP:0100277)2.15591610
72Preauricular pit (HP:0004467)2.15591610
73Azoospermia (HP:0000027)2.14821379
74Pancytopenia (HP:0001876)2.14527162
75Increased CSF lactate (HP:0002490)2.14094568
76Action tremor (HP:0002345)2.13615561
77Increased serum lactate (HP:0002151)2.12689732
78Anxiety (HP:0000739)2.11862560
79Hyperammonemia (HP:0001987)2.11402463
80Microretrognathia (HP:0000308)2.11379777
81Limb hypertonia (HP:0002509)2.09894529
82Hyperinsulinemic hypoglycemia (HP:0000825)2.09637491
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09509040
84Muscle fiber atrophy (HP:0100295)2.07980046
85Increased nuchal translucency (HP:0010880)2.07299708
86Status epilepticus (HP:0002133)2.06896212
87Sleep apnea (HP:0010535)2.06347484
88Reticulocytopenia (HP:0001896)2.05594576
89Ragged-red muscle fibers (HP:0003200)2.01667581
90Unilateral renal agenesis (HP:0000122)2.00966423
91Abnormality of glycolysis (HP:0004366)2.00770813
92Myoglobinuria (HP:0002913)2.00017790
93Abnormal atrioventricular conduction (HP:0005150)1.99915081
94Abnormality of serine family amino acid metabolism (HP:0010894)1.99652697
95Abnormality of glycine metabolism (HP:0010895)1.99652697
96Hyperuricemia (HP:0002149)1.99359826
97Increased purine levels (HP:0004368)1.99359826
98Abnormal mitochondria in muscle tissue (HP:0008316)1.99335383
99Neurodegeneration (HP:0002180)1.99070587
100Turricephaly (HP:0000262)1.98785342
101Dysmetric saccades (HP:0000641)1.97651822
102Mitochondrial inheritance (HP:0001427)1.97404265
103Bowel incontinence (HP:0002607)1.97403884
104Spinal canal stenosis (HP:0003416)1.96655234
105Tinnitus (HP:0000360)1.96622958
106Multiple enchondromatosis (HP:0005701)1.95891276
107Ankle clonus (HP:0011448)1.95625059
108Torticollis (HP:0000473)1.94443324
109Rough bone trabeculation (HP:0100670)1.93894264
110Hyperbilirubinemia (HP:0002904)1.93223416
111Unsteady gait (HP:0002317)1.93056380
112Male infertility (HP:0003251)1.92532287
113Generalized tonic-clonic seizures (HP:0002069)1.92388745
114Palpitations (HP:0001962)1.92080475
115Postural instability (HP:0002172)1.90783498
116Pseudobulbar signs (HP:0002200)1.90393612
117Focal dystonia (HP:0004373)1.89293338
118Hyperacusis (HP:0010780)1.89190832
119Petechiae (HP:0000967)1.88740337
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88421135
121Prolonged bleeding time (HP:0003010)1.88013515
122Muscle stiffness (HP:0003552)1.87255867
123Myopathic facies (HP:0002058)1.85811423
124Abnormal large intestine physiology (HP:0012700)1.84504915
125Abnormality of the tricuspid valve (HP:0001702)1.83283215
126Proximal tubulopathy (HP:0000114)1.83269153
127Ventricular arrhythmia (HP:0004308)1.82762953
128Hypoparathyroidism (HP:0000829)1.82195339
129Bradykinesia (HP:0002067)1.82108842
130Hypomagnesemia (HP:0002917)1.81710200
131Neoplasm of the adrenal gland (HP:0100631)1.81667945
132Neonatal death (HP:0003811)1.81629042
133Abnormality of serum amino acid levels (HP:0003112)1.81411160
134Syncope (HP:0001279)1.81357880
135Acute myeloid leukemia (HP:0004808)1.80801327
136Hypercortisolism (HP:0001578)1.80692577
137Growth hormone excess (HP:0000845)1.80075463
138Impaired platelet aggregation (HP:0003540)1.77407521
139Abnormal platelet function (HP:0011869)1.77407521
140Postural tremor (HP:0002174)1.77057059
141Impaired smooth pursuit (HP:0007772)1.76434365
142Prolonged QT interval (HP:0001657)1.76003407
143Abnormality of renin-angiotensin system (HP:0000847)1.75111161
144Supranuclear gaze palsy (HP:0000605)1.75107461
145Reduced antithrombin III activity (HP:0001976)1.74391398
146Acute necrotizing encephalopathy (HP:0006965)1.73508454
147Increased serum pyruvate (HP:0003542)1.73315853
148Esophageal neoplasm (HP:0100751)1.72140761
149Neoplasm of head and neck (HP:0012288)1.72140761
150Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71762729
151Craniofacial dystonia (HP:0012179)1.70439389
152Gaze-evoked nystagmus (HP:0000640)1.70242441
153Adrenal overactivity (HP:0002717)1.70057763
154Dysphonia (HP:0001618)1.69356568
155Lipid accumulation in hepatocytes (HP:0006561)1.68918426
15611 pairs of ribs (HP:0000878)1.68560784
157Increased circulating renin level (HP:0000848)1.68161152
158Abnormality of ocular smooth pursuit (HP:0000617)1.67685879
159Ileus (HP:0002595)1.67616409
160Distal upper limb amyotrophy (HP:0007149)1.64765255
161Upper limb amyotrophy (HP:0009129)1.64765255
162Chronic bronchitis (HP:0004469)1.63783099
163Abnormal eating behavior (HP:0100738)1.61466708
164Acute encephalopathy (HP:0006846)1.60883380
165Hyperaldosteronism (HP:0000859)1.59422950
166Hyperactive renin-angiotensin system (HP:0000841)1.58476489
167Hypokinesia (HP:0002375)1.57654097
168CNS hypomyelination (HP:0003429)1.56296379
169Skin pits (HP:0100276)1.56022448
170Abnormality of the salivary glands (HP:0010286)1.55278438
171Leukodystrophy (HP:0002415)1.54658442
172Overriding aorta (HP:0002623)1.54043241
173Sensory axonal neuropathy (HP:0003390)1.53860260
174Hyponatremia (HP:0002902)1.53727661
175Deep palmar crease (HP:0006191)1.52849300
176Polycystic kidney dysplasia (HP:0000113)1.52657693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.40050590
2NEK14.19657868
3PINK12.87397662
4WEE12.67987208
5CAMKK12.64033489
6LMTK22.50313346
7EIF2AK12.48823999
8ICK2.44807476
9VRK22.41676336
10BRSK12.33666371
11ACVR1B2.25563301
12SIK12.18166254
13BRSK22.17301448
14SCYL22.12642784
15PRKD32.08707210
16CAMKK22.08068467
17NTRK32.03691673
18PKN22.03405738
19MAP3K122.01982346
20STK381.83823566
21DMPK1.83809482
22KSR21.78427517
23EPHA21.75981900
24MUSK1.74390382
25NEK21.73223293
26WNK41.72120019
27MST1R1.68357708
28CDC71.65739065
29CCNB11.64659354
30NME21.64152297
31CDK191.63696254
32LATS21.59177815
33TAF11.57745340
34DAPK21.57433920
35BCKDK1.57057241
36TAOK11.56524031
37DAPK11.53119237
38MAP3K91.50588852
39TRIB31.48917802
40MAP2K71.42580201
41UHMK11.41385003
42RAF11.37304644
43TNIK1.37287162
44CDK121.35337923
45PHKG11.33881771
46PHKG21.33881771
47CAMK11.32914592
48NTRK11.31320863
49PDK41.29847697
50PDK31.29847697
51EPHA41.28244918
52MAP2K61.23316007
53TYRO31.18952266
54RIPK41.18575373
55TEC1.16435399
56ALK1.15821368
57MINK11.14316638
58FLT31.14108396
59NTRK21.13969930
60BMX1.08839598
61MAP2K31.07464126
62SIK21.05818277
63BRAF1.03685799
64PLK41.02402589
65RPS6KA41.00882793
66MAP3K131.00357338
67ARAF0.98528810
68RIPK10.94714274
69STK160.94693394
70FGFR40.94611872
71MAP2K40.91931324
72MAPK120.91701356
73MAPKAPK50.91531381
74MAP3K100.90669279
75PDK20.90235110
76PRKG20.88078821
77MARK20.86508399
78CDK40.86412724
79CSNK1E0.85289313
80MTOR0.79936807
81PRKCI0.79847601
82MAP3K20.79684645
83TNK20.79082446
84DYRK30.78785510
85PTK20.78741566
86PLK10.78491049
87PRPF4B0.77955462
88LRRK20.75838261
89AURKB0.75701972
90TESK10.75427427
91PDK10.75345097
92RPS6KB20.74906330
93HIPK20.74307672
94MAP3K40.72794565
95SRPK10.71437442
96CDK150.70008783
97CDK11A0.69902946
98MAP3K10.69160360
99TIE10.69020164
100PRKCH0.68867372
101KIT0.67574725
102CDK140.67430622
103CDK90.66984938
104STK390.65983057
105GRK50.65709616
106SGK20.65436106
107SGK30.64989483
108CDC42BPA0.63811817
109ATR0.63724708
110MAPK100.62606829
111MST40.62229919
112CDK70.62014270
113MAP3K110.61646069
114VRK10.61570556
115CDK180.60484418
116CAMK2D0.59487201
117CHEK10.56641725
118TAOK20.56103869
119MAP2K20.55767296
120PTK60.54927777
121CAMK40.54664555
122MAP3K80.54389462
123MAP3K70.52986047
124JAK20.52812990
125CAMK2G0.52675551
126KSR10.52245878
127IRAK30.51108716
128STK240.50837402
129MAP4K10.50186191
130CDK10.49990499
131CAMK1G0.49635570
132EIF2AK30.49624476
133SGK10.49087611
134BTK0.48867477
135GSK3B0.48051569
136EIF2AK20.47733015
137MAPK140.47664514
138MET0.47402837
139RPS6KA30.47369303
140PIK3CA0.47284878
141MATK0.47248137
142PRKCG0.46715138
143MKNK20.46022890
144TTK0.45980654
145NME10.45333177
146ILK0.44946995
147BUB10.44899351
148CDK80.43490283
149MAPK110.41751942
150PAK60.41447106
151EEF2K0.40349733
152ERBB30.39300774
153FRK0.37977408
154RET0.35473727
155MKNK10.35115843
156FES0.34773097
157CDK50.32130692
158RPS6KB10.30253216
159WNK30.29088152
160MAPKAPK30.27813895
161CDK20.27510871
162PDPK10.26412612

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.06158866
2DNA replication_Homo sapiens_hsa030303.83526687
3Nitrogen metabolism_Homo sapiens_hsa009102.80033239
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.58188648
5Ribosome_Homo sapiens_hsa030102.57952803
6Mismatch repair_Homo sapiens_hsa034302.42990454
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17322554
8Olfactory transduction_Homo sapiens_hsa047402.12496209
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12466092
10RNA polymerase_Homo sapiens_hsa030201.94010727
11Pyrimidine metabolism_Homo sapiens_hsa002401.89211041
12Vitamin B6 metabolism_Homo sapiens_hsa007501.83835637
13Base excision repair_Homo sapiens_hsa034101.82827675
14Arginine and proline metabolism_Homo sapiens_hsa003301.75289654
15Sulfur relay system_Homo sapiens_hsa041221.72422037
16Carbon metabolism_Homo sapiens_hsa012001.64092534
17Homologous recombination_Homo sapiens_hsa034401.62454117
18Pentose phosphate pathway_Homo sapiens_hsa000301.59878557
19Spliceosome_Homo sapiens_hsa030401.57502448
20Phenylalanine metabolism_Homo sapiens_hsa003601.55502460
21Propanoate metabolism_Homo sapiens_hsa006401.55408714
22RNA transport_Homo sapiens_hsa030131.50240337
23Folate biosynthesis_Homo sapiens_hsa007901.47674242
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46887977
25Oocyte meiosis_Homo sapiens_hsa041141.45646476
26Synaptic vesicle cycle_Homo sapiens_hsa047211.45594030
27Fatty acid degradation_Homo sapiens_hsa000711.42365678
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41808051
29Purine metabolism_Homo sapiens_hsa002301.38703063
30Long-term potentiation_Homo sapiens_hsa047201.36914765
31Circadian entrainment_Homo sapiens_hsa047131.36576808
32Nucleotide excision repair_Homo sapiens_hsa034201.35085562
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33856924
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.33120844
35Proteasome_Homo sapiens_hsa030501.32467628
36Biosynthesis of amino acids_Homo sapiens_hsa012301.30248266
37Fat digestion and absorption_Homo sapiens_hsa049751.24763500
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23647717
39Cell cycle_Homo sapiens_hsa041101.21484731
40RNA degradation_Homo sapiens_hsa030181.21051046
41Histidine metabolism_Homo sapiens_hsa003401.14817497
42Gastric acid secretion_Homo sapiens_hsa049711.12615346
43Caffeine metabolism_Homo sapiens_hsa002321.10040518
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08236964
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06628799
46Amphetamine addiction_Homo sapiens_hsa050311.05141690
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03326932
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00732163
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99302861
50Parkinsons disease_Homo sapiens_hsa050120.99169954
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97926495
52Insulin secretion_Homo sapiens_hsa049110.97263582
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94241522
54Cardiac muscle contraction_Homo sapiens_hsa042600.90116403
55Arginine biosynthesis_Homo sapiens_hsa002200.89764715
56GABAergic synapse_Homo sapiens_hsa047270.89465451
57Lysine degradation_Homo sapiens_hsa003100.88892307
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88545531
59Oxidative phosphorylation_Homo sapiens_hsa001900.88456023
60Notch signaling pathway_Homo sapiens_hsa043300.87927380
61Fatty acid elongation_Homo sapiens_hsa000620.87524994
62Pancreatic secretion_Homo sapiens_hsa049720.85304418
63Morphine addiction_Homo sapiens_hsa050320.85275006
64Thyroid cancer_Homo sapiens_hsa052160.84685523
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.83815865
66beta-Alanine metabolism_Homo sapiens_hsa004100.83591472
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83180059
68Glutamatergic synapse_Homo sapiens_hsa047240.81774057
69Thyroid hormone synthesis_Homo sapiens_hsa049180.81338627
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.80925268
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80356710
72Cocaine addiction_Homo sapiens_hsa050300.79930097
73Vitamin digestion and absorption_Homo sapiens_hsa049770.78218291
74Tyrosine metabolism_Homo sapiens_hsa003500.76996320
75N-Glycan biosynthesis_Homo sapiens_hsa005100.76547877
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75152524
77Collecting duct acid secretion_Homo sapiens_hsa049660.74221204
78Huntingtons disease_Homo sapiens_hsa050160.73959444
79mRNA surveillance pathway_Homo sapiens_hsa030150.72501775
80Salivary secretion_Homo sapiens_hsa049700.70730970
81Bile secretion_Homo sapiens_hsa049760.70431063
82Pyruvate metabolism_Homo sapiens_hsa006200.70340037
83Alzheimers disease_Homo sapiens_hsa050100.69563011
84Cholinergic synapse_Homo sapiens_hsa047250.67142749
85Dopaminergic synapse_Homo sapiens_hsa047280.65467086
86Calcium signaling pathway_Homo sapiens_hsa040200.65132023
87Galactose metabolism_Homo sapiens_hsa000520.64998534
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62673781
89AMPK signaling pathway_Homo sapiens_hsa041520.61435391
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60332715
91PPAR signaling pathway_Homo sapiens_hsa033200.59133494
92Retinol metabolism_Homo sapiens_hsa008300.58974234
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58273573
94Fatty acid metabolism_Homo sapiens_hsa012120.58171118
95Mineral absorption_Homo sapiens_hsa049780.57960336
96Nicotine addiction_Homo sapiens_hsa050330.57376330
97Renin secretion_Homo sapiens_hsa049240.56878942
98GnRH signaling pathway_Homo sapiens_hsa049120.56529667
99Prion diseases_Homo sapiens_hsa050200.56319778
100Butanoate metabolism_Homo sapiens_hsa006500.56090373
101Melanogenesis_Homo sapiens_hsa049160.56072739
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55269178
103Glutathione metabolism_Homo sapiens_hsa004800.55085892
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53496772
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53263372
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53146777
107cAMP signaling pathway_Homo sapiens_hsa040240.52689891
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49285479
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48471365
110Glucagon signaling pathway_Homo sapiens_hsa049220.48074958
111Glioma_Homo sapiens_hsa052140.47760789
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47032769
113Oxytocin signaling pathway_Homo sapiens_hsa049210.46540221
114Fatty acid biosynthesis_Homo sapiens_hsa000610.46204420
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45953631
116Fructose and mannose metabolism_Homo sapiens_hsa000510.45089623
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44559233
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44441600
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.43967345
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43583002
121Vibrio cholerae infection_Homo sapiens_hsa051100.43237931
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42832217
123Circadian rhythm_Homo sapiens_hsa047100.41707994
124Insulin signaling pathway_Homo sapiens_hsa049100.40253297
125Platelet activation_Homo sapiens_hsa046110.39944817
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39261129
127Non-small cell lung cancer_Homo sapiens_hsa052230.38278527
128Peroxisome_Homo sapiens_hsa041460.35903482
129One carbon pool by folate_Homo sapiens_hsa006700.35704074
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35517854
131Type I diabetes mellitus_Homo sapiens_hsa049400.35094864
132Basal transcription factors_Homo sapiens_hsa030220.34766852
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32911458
134p53 signaling pathway_Homo sapiens_hsa041150.32763449
135Taste transduction_Homo sapiens_hsa047420.32395634
136Insulin resistance_Homo sapiens_hsa049310.31904919

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