MT-ATP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.31498983
2central nervous system myelination (GO:0022010)8.31498983
3viral transcription (GO:0019083)5.43083135
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.36152016
5translational termination (GO:0006415)5.23332531
6fatty acid elongation (GO:0030497)5.06219322
7neuron cell-cell adhesion (GO:0007158)4.73460550
8long-chain fatty acid biosynthetic process (GO:0042759)4.65989025
9myelination (GO:0042552)4.54913832
10axon ensheathment (GO:0008366)4.49050414
11ensheathment of neurons (GO:0007272)4.49050414
12presynaptic membrane assembly (GO:0097105)4.42717521
13presynaptic membrane organization (GO:0097090)4.35539907
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31139112
15limb bud formation (GO:0060174)4.28469985
16chaperone-mediated protein transport (GO:0072321)4.26940256
17cotranslational protein targeting to membrane (GO:0006613)4.23397319
18protein targeting to ER (GO:0045047)4.19558287
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.16609067
20ribosomal small subunit biogenesis (GO:0042274)4.03589690
21cellular protein complex disassembly (GO:0043624)4.02276507
22translational elongation (GO:0006414)4.02260157
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.01823491
24neuron remodeling (GO:0016322)3.89163596
25protein localization to endoplasmic reticulum (GO:0070972)3.79611697
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.77538912
27negative regulation of protein localization to cell surface (GO:2000009)3.73332612
28neuron recognition (GO:0008038)3.72974271
29negative regulation of neurotransmitter transport (GO:0051589)3.72531630
30viral life cycle (GO:0019058)3.70596740
31neuronal action potential propagation (GO:0019227)3.65941750
32ribosomal small subunit assembly (GO:0000028)3.60543494
33* hydrogen ion transmembrane transport (GO:1902600)3.58006734
34potassium ion import (GO:0010107)3.50028823
35cochlea development (GO:0090102)3.45984942
36transmission of nerve impulse (GO:0019226)3.43650916
37protein complex disassembly (GO:0043241)3.39007086
38* ATP biosynthetic process (GO:0006754)3.38619585
39translational initiation (GO:0006413)3.38005109
40L-amino acid import (GO:0043092)3.36200719
41oligodendrocyte differentiation (GO:0048709)3.34976141
42negative regulation of neurotransmitter secretion (GO:0046929)3.29254376
43lateral sprouting from an epithelium (GO:0060601)3.28444884
44photoreceptor cell differentiation (GO:0046530)3.26830998
45eye photoreceptor cell differentiation (GO:0001754)3.26830998
46regulation of collateral sprouting (GO:0048670)3.22279004
47positive regulation of action potential (GO:0045760)3.18675305
48macromolecular complex disassembly (GO:0032984)3.17196687
49dendritic spine morphogenesis (GO:0060997)3.15804656
50* proton transport (GO:0015992)3.15765958
51* respiratory electron transport chain (GO:0022904)3.14649190
52glycerophospholipid catabolic process (GO:0046475)3.13275681
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.12869159
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.12486895
55* hydrogen transport (GO:0006818)3.12015040
56maturation of SSU-rRNA (GO:0030490)3.11619850
57positive regulation of synapse assembly (GO:0051965)3.11337636
58* mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08190976
59glutamate receptor signaling pathway (GO:0007215)3.07684761
60negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.06602685
61* electron transport chain (GO:0022900)3.05922864
62nephron epithelium morphogenesis (GO:0072088)3.04555778
63nephron tubule morphogenesis (GO:0072078)3.04555778
64* energy coupled proton transport, down electrochemical gradient (GO:0015985)3.04367786
65* ATP synthesis coupled proton transport (GO:0015986)3.04367786
66oxidative phosphorylation (GO:0006119)3.04366540
67midbrain development (GO:0030901)3.04343272
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03991946
69axonal fasciculation (GO:0007413)3.00948648
70cerebral cortex radially oriented cell migration (GO:0021799)3.00581472
71axonemal dynein complex assembly (GO:0070286)3.00329131
72gamma-aminobutyric acid transport (GO:0015812)2.99356022
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98949359
74cerebellar Purkinje cell layer development (GO:0021680)2.97840610
75protein complex biogenesis (GO:0070271)2.96149490
76substantia nigra development (GO:0021762)2.93721960
77spliceosomal complex assembly (GO:0000245)2.93691039
78aerobic respiration (GO:0009060)2.91626625
79import into cell (GO:0098657)2.91524638
80* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89564997
81positive regulation of oligodendrocyte differentiation (GO:0048714)2.86727516
82protein neddylation (GO:0045116)2.86674751
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.84168376
84NADH dehydrogenase complex assembly (GO:0010257)2.84168376
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84168376
86* purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83588847
87neurotransmitter uptake (GO:0001504)2.82350054
88response to methylmercury (GO:0051597)2.80946681
89keratinocyte development (GO:0003334)2.79399062
90mitochondrial respiratory chain complex assembly (GO:0033108)2.77440931
91asymmetric protein localization (GO:0008105)2.77408654
92protein targeting to membrane (GO:0006612)2.76787639
93cranial nerve development (GO:0021545)2.75557894
94establishment of mitochondrion localization (GO:0051654)2.73415400
95retina layer formation (GO:0010842)2.70422055
96apical protein localization (GO:0045176)2.69970607
97regulation of catecholamine metabolic process (GO:0042069)2.69854742
98regulation of dopamine metabolic process (GO:0042053)2.69854742
99response to insecticide (GO:0017085)2.69786117
100membrane assembly (GO:0071709)2.69249998
101regulation of gene silencing by RNA (GO:0060966)2.68241507
102regulation of posttranscriptional gene silencing (GO:0060147)2.68241507
103regulation of gene silencing by miRNA (GO:0060964)2.68241507
104paraxial mesoderm development (GO:0048339)2.67656931
105dopamine biosynthetic process (GO:0042416)2.66240602
106amino acid import (GO:0043090)2.65748775
107vocalization behavior (GO:0071625)2.65554024
108cholesterol biosynthetic process (GO:0006695)2.64118309
109cellular response to epinephrine stimulus (GO:0071872)2.63353579
110mating behavior (GO:0007617)2.62624335
111regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62556665
112protein localization to synapse (GO:0035418)2.61868815
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61003161
114response to epinephrine (GO:0071871)2.60806805
115protein-cofactor linkage (GO:0018065)2.60573980
116myelin maintenance (GO:0043217)2.59589942
117termination of RNA polymerase III transcription (GO:0006386)2.58870299
118transcription elongation from RNA polymerase III promoter (GO:0006385)2.58870299
119ribosomal large subunit biogenesis (GO:0042273)2.58159823
120adult walking behavior (GO:0007628)2.56000805
121postsynaptic membrane organization (GO:0001941)2.54938753
122regulation of feeding behavior (GO:0060259)2.53844986
123mechanosensory behavior (GO:0007638)2.53582731
124response to redox state (GO:0051775)2.53250789
125notochord development (GO:0030903)2.53149328
126positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52980126
127organ growth (GO:0035265)2.52828987
128histone H2B ubiquitination (GO:0033523)2.52543376
129regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52131148
130regulation of mitochondrial translation (GO:0070129)2.52125091
131neurofilament cytoskeleton organization (GO:0060052)2.51954036
132sequestering of actin monomers (GO:0042989)2.50204048
133sulfation (GO:0051923)2.49270980
134startle response (GO:0001964)2.48952957
135astrocyte development (GO:0014002)2.48152755
136inner mitochondrial membrane organization (GO:0007007)2.47712150
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.47584433
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47266131
139positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46533173
140negative regulation of axon extension (GO:0030517)2.46362120
141behavioral response to nicotine (GO:0035095)2.46251051
142intracellular protein transmembrane import (GO:0044743)2.44134663
143regulation of glutamate secretion (GO:0014048)2.43611656
144short-term memory (GO:0007614)2.43023701
145peptidyl-tyrosine autophosphorylation (GO:0038083)2.43012082
146myelination in peripheral nervous system (GO:0022011)2.42965935
147peripheral nervous system axon ensheathment (GO:0032292)2.42965935
148positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.42780348
149* ribonucleoside triphosphate biosynthetic process (GO:0009201)2.41071541
150neuronal stem cell maintenance (GO:0097150)2.40684117
151auditory behavior (GO:0031223)2.39409984
152GPI anchor metabolic process (GO:0006505)2.39327076
153GPI anchor biosynthetic process (GO:0006506)2.39301104
154translation (GO:0006412)2.39184079
155neuromuscular process controlling posture (GO:0050884)2.39070712
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39010002
157cerebellar granule cell differentiation (GO:0021707)2.38895781
158neuron-neuron synaptic transmission (GO:0007270)2.38739513
159mRNA catabolic process (GO:0006402)2.38621945
160dopaminergic neuron differentiation (GO:0071542)2.38540126
161regulation of oxidative phosphorylation (GO:0002082)2.38167138
162epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.37770457
163calcium-mediated signaling using intracellular calcium source (GO:0035584)2.35434632
164isoprenoid biosynthetic process (GO:0008299)2.35292758
165regulation of pigment cell differentiation (GO:0050932)2.35219835
166regulation of synapse assembly (GO:0051963)2.35190606
167renal tubule morphogenesis (GO:0061333)2.35039910
168otic vesicle formation (GO:0030916)2.33160879
169dendrite development (GO:0016358)2.31991104
170cellular potassium ion homeostasis (GO:0030007)2.31128512
171sterol biosynthetic process (GO:0016126)2.30622664
172regulation of dendritic spine development (GO:0060998)2.30335680
173regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29344875
174regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.29271705
175neuronal ion channel clustering (GO:0045161)2.29251784
176negative regulation of execution phase of apoptosis (GO:1900118)2.29159945
177positive regulation of cellular amine metabolic process (GO:0033240)2.28885949
178regulation of dendritic spine morphogenesis (GO:0061001)2.26802862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22314368
2GBX2_23144817_ChIP-Seq_PC3_Human3.29188469
3TAF15_26573619_Chip-Seq_HEK293_Human2.86789987
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86312489
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67736935
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67581720
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.67046514
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.48951514
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39377020
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39166050
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34685633
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34685633
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33345948
14VDR_22108803_ChIP-Seq_LS180_Human2.32774522
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31556290
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28270858
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.28247878
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24862281
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.18428265
20AR_21572438_ChIP-Seq_LNCaP_Human2.12161421
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10923937
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07329881
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05767019
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04861961
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01449308
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.96713491
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94979496
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91883514
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.90028981
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89329444
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.87500790
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87407823
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83341674
34FUS_26573619_Chip-Seq_HEK293_Human1.82662677
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77999767
36P300_19829295_ChIP-Seq_ESCs_Human1.73339456
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71863275
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68694838
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68023958
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67885873
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67715618
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.67522085
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67285689
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67285689
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67285689
46RNF2_27304074_Chip-Seq_NSC_Mouse1.63230203
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.61999701
48ER_23166858_ChIP-Seq_MCF-7_Human1.60299304
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60034962
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.56826735
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.54413616
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53664678
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49346321
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47891447
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45995128
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43852542
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.43455732
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42221741
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.41797679
60REST_21632747_ChIP-Seq_MESCs_Mouse1.41191048
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39757579
62SMAD4_21799915_ChIP-Seq_A2780_Human1.37373590
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35290972
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30778812
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.29778973
66IGF1R_20145208_ChIP-Seq_DFB_Human1.28814058
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.27747229
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22235935
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22039915
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.21830617
71MYC_18940864_ChIP-ChIP_HL60_Human1.21077999
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20531157
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.20502979
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19481245
75TP53_18474530_ChIP-ChIP_U2OS_Human1.18202844
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17118486
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.16215891
78DROSHA_22980978_ChIP-Seq_HELA_Human1.15071128
79ZNF274_21170338_ChIP-Seq_K562_Hela1.14233705
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14098007
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14004102
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13143469
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12992437
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12045990
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.11569529
86EWS_26573619_Chip-Seq_HEK293_Human1.11099402
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.10739528
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09836882
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09746126
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.08123615
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07090910
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.06994991
93RUNX2_22187159_ChIP-Seq_PCA_Human1.06733306
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.06486440
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06195729
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05782608
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05325619
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.04931562
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04831208
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.04632580
101AR_25329375_ChIP-Seq_VCAP_Human1.04452997
102AHR_22903824_ChIP-Seq_MCF-7_Human1.04179287
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.02457348
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01847189
105TP53_16413492_ChIP-PET_HCT116_Human1.01548813
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01150914
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00907377
108KDM2B_26808549_Chip-Seq_REH_Human1.00548153
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00161259
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99955707
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.99826078
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99688708
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99688708
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98484662
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97440855
116REST_18959480_ChIP-ChIP_MESCs_Mouse0.97358688
117P53_22387025_ChIP-Seq_ESCs_Mouse0.97031370
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.96784842
119STAT3_23295773_ChIP-Seq_U87_Human0.96284073
120STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96270974
121IRF1_19129219_ChIP-ChIP_H3396_Human0.96078071
122BCAT_22108803_ChIP-Seq_LS180_Human0.95992779
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95762336
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95760031
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95642013
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95444820
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95208095
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95170995
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94984484
130CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94691131
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94557148
132THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92187336
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89832489
134TTF2_22483619_ChIP-Seq_HELA_Human0.89696752
135SOX9_26525672_Chip-Seq_HEART_Mouse0.88860911
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87796151
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87261973
138CTCF_27219007_Chip-Seq_Bcells_Human0.84671482
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83478724
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83354595
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83083529
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82102912
143ETS1_20019798_ChIP-Seq_JURKAT_Human0.81765189
144XRN2_22483619_ChIP-Seq_HELA_Human0.81692132
145RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80813834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.32478553
2MP0003136_yellow_coat_color3.07644430
3MP0000920_abnormal_myelination2.92512954
4MP0004270_analgesia2.79419120
5MP0005423_abnormal_somatic_nervous2.73025217
6MP0003941_abnormal_skin_development2.60349210
7MP0001529_abnormal_vocalization2.58174734
8MP0001486_abnormal_startle_reflex2.52740501
9MP0006292_abnormal_olfactory_placode2.44138120
10MP0005409_darkened_coat_color2.39207112
11MP0002272_abnormal_nervous_system2.38240471
12MP0004742_abnormal_vestibular_system2.36079728
13MP0003635_abnormal_synaptic_transmissio2.29767319
14MP0000778_abnormal_nervous_system2.28868987
15MP0002064_seizures2.27187589
16MP0009379_abnormal_foot_pigmentation2.26678593
17MP0009745_abnormal_behavioral_response2.23747755
18MP0001905_abnormal_dopamine_level2.12411952
19MP0009046_muscle_twitch2.10198419
20MP0004381_abnormal_hair_follicle2.04496495
21MP0004859_abnormal_synaptic_plasticity2.04091882
22MP0001440_abnormal_grooming_behavior1.98677739
23MP0002734_abnormal_mechanical_nocicepti1.94127615
24MP0001968_abnormal_touch/_nociception1.90192235
25MP0003950_abnormal_plasma_membrane1.87608789
26MP0006276_abnormal_autonomic_nervous1.87464275
27MP0004142_abnormal_muscle_tone1.85480770
28* MP0002572_abnormal_emotion/affect_behav1.83851057
29MP0005171_absent_coat_pigmentation1.78137099
30MP0003329_amyloid_beta_deposits1.77934435
31MP0003690_abnormal_glial_cell1.74906995
32MP0001485_abnormal_pinna_reflex1.74486324
33MP0002063_abnormal_learning/memory/cond1.74084409
34MP0003011_delayed_dark_adaptation1.70756844
35MP0004133_heterotaxia1.69286576
36MP0002102_abnormal_ear_morphology1.65904926
37MP0003283_abnormal_digestive_organ1.65451598
38MP0003122_maternal_imprinting1.65259497
39MP0004885_abnormal_endolymph1.64679062
40MP0003938_abnormal_ear_development1.63422442
41MP0002653_abnormal_ependyma_morphology1.58715105
42MP0002067_abnormal_sensory_capabilities1.58156435
43MP0005551_abnormal_eye_electrophysiolog1.52638749
44MP0003634_abnormal_glial_cell1.49173784
45MP0000566_synostosis1.48576777
46MP0001188_hyperpigmentation1.45868427
47MP0002736_abnormal_nociception_after1.45214228
48MP0002277_abnormal_respiratory_mucosa1.43680566
49MP0001970_abnormal_pain_threshold1.43583971
50MP0002735_abnormal_chemical_nociception1.41954710
51MP0001501_abnormal_sleep_pattern1.41932407
52MP0002184_abnormal_innervation1.41911046
53MP0004145_abnormal_muscle_electrophysio1.40132386
54MP0002733_abnormal_thermal_nociception1.30218210
55MP0002882_abnormal_neuron_morphology1.27765656
56MP0001963_abnormal_hearing_physiology1.24865177
57MP0000026_abnormal_inner_ear1.24112639
58MP0004924_abnormal_behavior1.23797058
59MP0005386_behavior/neurological_phenoty1.23797058
60MP0006072_abnormal_retinal_apoptosis1.22116419
61MP0002752_abnormal_somatic_nervous1.20052620
62MP0000462_abnormal_digestive_system1.19260235
63MP0000383_abnormal_hair_follicle1.19130238
64MP0003878_abnormal_ear_physiology1.18946614
65MP0005377_hearing/vestibular/ear_phenot1.18946614
66MP0001346_abnormal_lacrimal_gland1.18205205
67MP0002229_neurodegeneration1.17798121
68MP0000955_abnormal_spinal_cord1.17774705
69MP0008995_early_reproductive_senescence1.16099096
70MP0002557_abnormal_social/conspecific_i1.15561087
71MP0001293_anophthalmia1.15357271
72MP0005645_abnormal_hypothalamus_physiol1.14928431
73MP0002066_abnormal_motor_capabilities/c1.12843117
74MP0010678_abnormal_skin_adnexa1.12723634
75MP0008569_lethality_at_weaning1.11706573
76MP0002638_abnormal_pupillary_reflex1.11236624
77MP0008875_abnormal_xenobiotic_pharmacok1.10790570
78MP0000762_abnormal_tongue_morphology1.10376969
79MP0000631_abnormal_neuroendocrine_gland1.08718744
80MP0001984_abnormal_olfaction1.07667276
81MP0005410_abnormal_fertilization1.07100389
82MP0003890_abnormal_embryonic-extraembry1.05773118
83MP0004215_abnormal_myocardial_fiber1.04426974
84MP0004019_abnormal_vitamin_homeostasis1.04241185
85MP0005623_abnormal_meninges_morphology1.03198575
86MP0001286_abnormal_eye_development1.00296380
87MP0003632_abnormal_nervous_system0.99124477
88MP0003119_abnormal_digestive_system0.97065580
89MP0002697_abnormal_eye_size0.96613855
90MP0009250_abnormal_appendicular_skeleto0.95835868
91MP0003942_abnormal_urinary_system0.95359126
92MP0002938_white_spotting0.94824162
93MP0005646_abnormal_pituitary_gland0.93987845
94MP0005379_endocrine/exocrine_gland_phen0.93611894
95MP0003123_paternal_imprinting0.92999646
96MP0000647_abnormal_sebaceous_gland0.91502483
97MP0000579_abnormal_nail_morphology0.91254031
98MP0005195_abnormal_posterior_eye0.91218372
99MP0003861_abnormal_nervous_system0.90146660
100MP0001299_abnormal_eye_distance/0.89415889
101MP0002152_abnormal_brain_morphology0.89008768
102MP0003631_nervous_system_phenotype0.88776957
103MP0002822_catalepsy0.87788453
104MP0004134_abnormal_chest_morphology0.87643331
105MP0003121_genomic_imprinting0.87380810
106MP0003638_abnormal_response/metabolism_0.86979046
107MP0002909_abnormal_adrenal_gland0.86406447
108MP0003937_abnormal_limbs/digits/tail_de0.85310310
109MP0001502_abnormal_circadian_rhythm0.84790800
110MP0005253_abnormal_eye_physiology0.83806024
111MP0003137_abnormal_impulse_conducting0.81941125
112MP0004043_abnormal_pH_regulation0.81285817
113MP0001727_abnormal_embryo_implantation0.81100131
114MP0003195_calcinosis0.80037662
115MP0003633_abnormal_nervous_system0.79929592
116MP0002089_abnormal_postnatal_growth/wei0.78890817
117MP0000467_abnormal_esophagus_morphology0.76764529
118MP0004085_abnormal_heartbeat0.76640790
119MP0003567_abnormal_fetal_cardiomyocyte0.75575745
120MP0000049_abnormal_middle_ear0.75196924
121MP0002837_dystrophic_cardiac_calcinosis0.74071081
122MP0001661_extended_life_span0.73814740
123MP0001340_abnormal_eyelid_morphology0.73673754
124MP0008877_abnormal_DNA_methylation0.73062213
125MP0005451_abnormal_body_composition0.72816471
126MP0005503_abnormal_tendon_morphology0.72562783
127MP0003755_abnormal_palate_morphology0.72505798
128MP0002295_abnormal_pulmonary_circulatio0.72061109
129MP0010030_abnormal_orbit_morphology0.71986076
130MP0002796_impaired_skin_barrier0.71670630
131MP0002139_abnormal_hepatobiliary_system0.71455458
132MP0002282_abnormal_trachea_morphology0.71127315
133MP0001851_eye_inflammation0.69983832
134MP0003698_abnormal_male_reproductive0.69358430
135MP0002090_abnormal_vision0.69137164
136MP0000751_myopathy0.69043107
137MP0002249_abnormal_larynx_morphology0.68421968
138MP0009384_cardiac_valve_regurgitation0.68149664

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.11917881
2Neurofibrillary tangles (HP:0002185)4.63049210
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.59629510
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.59629510
5Congenital, generalized hypertrichosis (HP:0004540)4.21764079
6Abnormal number of erythroid precursors (HP:0012131)3.83531647
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.78892210
8Abnormality of cells of the erythroid lineage (HP:0012130)3.71787774
9Macrocytic anemia (HP:0001972)3.66331507
10Cerebral inclusion bodies (HP:0100314)3.51246548
11Abnormality of the corticospinal tract (HP:0002492)3.34792784
12Focal motor seizures (HP:0011153)3.30169755
13Peripheral hypomyelination (HP:0007182)3.29549098
14Sensory axonal neuropathy (HP:0003390)3.25893202
15Acute necrotizing encephalopathy (HP:0006965)3.22230678
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.15725872
17Absent/shortened dynein arms (HP:0200106)3.15725872
18Abnormal ciliary motility (HP:0012262)3.13830446
19Limb dystonia (HP:0002451)3.13614188
20Bilateral microphthalmos (HP:0007633)3.03502842
21Reticulocytopenia (HP:0001896)2.93800495
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.86988647
23Abnormality of the lacrimal duct (HP:0011481)2.85655777
24Progressive macrocephaly (HP:0004481)2.84626586
25Pallor (HP:0000980)2.82725538
26Partial duplication of the phalanx of hand (HP:0009999)2.81987744
27Abnormality of the nasolacrimal system (HP:0000614)2.78903244
28Retinal dysplasia (HP:0007973)2.78762831
29Abnormal respiratory motile cilium physiology (HP:0012261)2.76261882
30Maternal diabetes (HP:0009800)2.74765535
31Rhinitis (HP:0012384)2.74607545
32Atonic seizures (HP:0010819)2.73396925
33True hermaphroditism (HP:0010459)2.71200714
34Abnormality of secondary sexual hair (HP:0009888)2.71134449
35Abnormality of the axillary hair (HP:0100134)2.71134449
36Alacrima (HP:0000522)2.66321486
37Renal Fanconi syndrome (HP:0001994)2.65919247
38Abnormal respiratory motile cilium morphology (HP:0005938)2.61377579
39Abnormal respiratory epithelium morphology (HP:0012253)2.61377579
40Aplasia involving bones of the extremities (HP:0009825)2.59477907
41Aplasia involving bones of the upper limbs (HP:0009823)2.59477907
42Aplasia of the phalanges of the hand (HP:0009802)2.59477907
43Supranuclear gaze palsy (HP:0000605)2.59400380
44Synostosis involving the elbow (HP:0003938)2.59206039
45Humeroradial synostosis (HP:0003041)2.59206039
46Congenital ichthyosiform erythroderma (HP:0007431)2.56878550
47Exertional dyspnea (HP:0002875)2.55468809
48Pancreatic fibrosis (HP:0100732)2.53823600
49Mitochondrial inheritance (HP:0001427)2.49672534
50Abnormal mitochondria in muscle tissue (HP:0008316)2.47062117
51Acute encephalopathy (HP:0006846)2.46046040
52Focal seizures (HP:0007359)2.45442867
53Increased CSF lactate (HP:0002490)2.44749531
54Leukodystrophy (HP:0002415)2.42860641
55Increased hepatocellular lipid droplets (HP:0006565)2.41232196
56Broad-based gait (HP:0002136)2.39007833
57Morphological abnormality of the inner ear (HP:0011390)2.35496558
58Esophageal atresia (HP:0002032)2.33239739
59Termporal pattern (HP:0011008)2.33220428
60Insidious onset (HP:0003587)2.33220428
61Anophthalmia (HP:0000528)2.31599286
62Absent septum pellucidum (HP:0001331)2.30765829
63Large for gestational age (HP:0001520)2.30390702
64Myokymia (HP:0002411)2.29227263
65Hyperventilation (HP:0002883)2.29066623
66Thickened helices (HP:0000391)2.27764604
67Cupped ear (HP:0000378)2.26979467
68Dysmetria (HP:0001310)2.24563275
69Birth length less than 3rd percentile (HP:0003561)2.24047637
70Optic disc pallor (HP:0000543)2.23795225
71Concave nail (HP:0001598)2.23016389
72Rib fusion (HP:0000902)2.22970894
73Onion bulb formation (HP:0003383)2.22155661
74Hypoplastic pelvis (HP:0008839)2.19208551
75Sleep apnea (HP:0010535)2.16948927
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16587607
77Homocystinuria (HP:0002156)2.13906157
78Abnormality of homocysteine metabolism (HP:0010919)2.13906157
79White forelock (HP:0002211)2.13658582
80Spastic gait (HP:0002064)2.13229045
81Hemiparesis (HP:0001269)2.13225554
82Decreased lacrimation (HP:0000633)2.13121962
83Abnormality of the septum pellucidum (HP:0007375)2.12272636
84Patchy hypopigmentation of hair (HP:0011365)2.12068085
85Muscle hypertrophy of the lower extremities (HP:0008968)2.09838676
86Increased intramyocellular lipid droplets (HP:0012240)2.09078678
87Aplasia cutis congenita (HP:0001057)2.08376384
88Dialeptic seizures (HP:0011146)2.07956374
89Ulnar claw (HP:0001178)2.07871989
90Epileptic encephalopathy (HP:0200134)2.06465433
913-Methylglutaconic aciduria (HP:0003535)2.04790777
92Clumsiness (HP:0002312)2.04294330
93Optic nerve hypoplasia (HP:0000609)2.03666266
94Hypoplasia of the iris (HP:0007676)2.01905270
95Hypomagnesemia (HP:0002917)2.01211266
96Partial duplication of thumb phalanx (HP:0009944)2.00649963
97Abnormal number of incisors (HP:0011064)2.00002950
98Anteriorly placed anus (HP:0001545)1.99033773
99Mixed hearing impairment (HP:0000410)1.98954234
100Metabolic alkalosis (HP:0200114)1.98580651
101Nasolacrimal duct obstruction (HP:0000579)1.96392418
102Hepatocellular necrosis (HP:0001404)1.95907683
103Split foot (HP:0001839)1.95714861
104Supernumerary bones of the axial skeleton (HP:0009144)1.94509932
105Supernumerary ribs (HP:0005815)1.94437058
106Abnormality of glycolysis (HP:0004366)1.94243488
107Increased serum pyruvate (HP:0003542)1.94243488
108Lipid accumulation in hepatocytes (HP:0006561)1.94077499
109Abnormality of the parietal bone (HP:0002696)1.93815881
110Septo-optic dysplasia (HP:0100842)1.93534974
111Vaginal atresia (HP:0000148)1.93307509
112Progressive cerebellar ataxia (HP:0002073)1.93067349
113Cerebral hemorrhage (HP:0001342)1.92738904
114Genital tract atresia (HP:0001827)1.92381753
115Cerebral edema (HP:0002181)1.92253314
116Chronic bronchitis (HP:0004469)1.91917572
117Abnormality of the middle phalanges of the toes (HP:0010183)1.90561576
118Midline defect of the nose (HP:0004122)1.90463183
119Pancreatic cysts (HP:0001737)1.90310274
120Chin dimple (HP:0010751)1.90240764
121Sclerocornea (HP:0000647)1.89960617
122X-linked dominant inheritance (HP:0001423)1.89101147
123Short hallux (HP:0010109)1.89021494
124Oral leukoplakia (HP:0002745)1.88935194
125Progressive inability to walk (HP:0002505)1.88784349
126Hyperinsulinemic hypoglycemia (HP:0000825)1.86637644
127Male pseudohermaphroditism (HP:0000037)1.86233450
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85986338
129Depressed nasal tip (HP:0000437)1.85760707
130Absence seizures (HP:0002121)1.85352762
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84734810
132Abnormality of binocular vision (HP:0011514)1.84627027
133Diplopia (HP:0000651)1.84627027
134Increased circulating renin level (HP:0000848)1.82040807
135Broad metatarsal (HP:0001783)1.81174009
136Abnormality of renal resorption (HP:0011038)1.81052688
137Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80444379
138Intention tremor (HP:0002080)1.80404122
139Overfolded helix (HP:0000396)1.80189924
140Febrile seizures (HP:0002373)1.79963078
141Hypoplastic left heart (HP:0004383)1.79286582
142Akinesia (HP:0002304)1.78902956
143Abnormality of cochlea (HP:0000375)1.78738962
144Infantile muscular hypotonia (HP:0008947)1.78623543
145Scanning speech (HP:0002168)1.78299157
146Respiratory difficulties (HP:0002880)1.78051542
147Abnormality of midbrain morphology (HP:0002418)1.78027918
148Molar tooth sign on MRI (HP:0002419)1.78027918
149Confusion (HP:0001289)1.77711598
150Symphalangism affecting the phalanges of the hand (HP:0009773)1.76042421
151Abnormal auditory evoked potentials (HP:0006958)1.75070397
152Medial flaring of the eyebrow (HP:0010747)1.74663278
153Anencephaly (HP:0002323)1.74309841
154Widely spaced teeth (HP:0000687)1.74274203
155Myelomeningocele (HP:0002475)1.73516225
156Generalized tonic-clonic seizures (HP:0002069)1.73455218
157Double outlet right ventricle (HP:0001719)1.72958910
158Congenital malformation of the right heart (HP:0011723)1.72958910
159Nephronophthisis (HP:0000090)1.72706504
160Hypothermia (HP:0002045)1.71746654
161Choanal stenosis (HP:0000452)1.69917656
162Cystic liver disease (HP:0006706)1.69526064
163Sex reversal (HP:0012245)1.69498742
164Abnormal sex determination (HP:0012244)1.69498742
165Hepatic necrosis (HP:0002605)1.69438342
166Abnormal pupillary function (HP:0007686)1.68983536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.56543769
2OXSR13.43122516
3CASK3.30386718
4PNCK3.27834225
5VRK23.13763120
6WEE12.97296254
7CDC72.79403094
8TNIK2.60923467
9EPHA42.44732498
10PKN12.20727147
11MARK12.03473231
12WNK42.01521733
13BCR1.99270026
14MST41.93903081
15TSSK61.83305786
16PBK1.80409835
17MUSK1.79219776
18MAPKAPK51.78416280
19NTRK31.72567288
20FGR1.72316533
21GRK71.71733259
22BUB11.69275789
23EPHB11.63310168
24CDK191.57560234
25UHMK11.57047563
26NTRK21.56720570
27LATS21.56631994
28FGFR21.54235366
29BMPR1B1.50979517
30CAMK2B1.47625375
31DYRK31.46683046
32PINK11.45466217
33MAP3K101.37016888
34MAPK151.35258923
35MAPK131.34857007
36NTRK11.30697716
37ROCK21.25664175
38WNK11.24309252
39CSNK1G31.22097729
40MET1.21490873
41CAMK2A1.20686950
42DYRK21.16930792
43CAMK2D1.13291887
44PAK31.13222511
45CSNK1A1L1.10982699
46NEK61.10428957
47PLK31.09342027
48NME11.08732829
49CDK121.07017642
50NEK21.06374988
51CSNK1G21.03966619
52TAF11.03053771
53MAP3K41.02698523
54PAK61.01967364
55FES1.01572076
56TTK1.00804852
57PRKCE0.98865384
58RIPK40.94271993
59CSNK1G10.93527804
60CDK50.92477724
61MAP2K70.90750646
62PHKG20.90476775
63PHKG10.90476775
64STK160.89408407
65BMPR20.89353522
66GRK50.87757872
67CSNK1E0.85779923
68IRAK20.83588553
69CAMK2G0.83237346
70SGK10.81716647
71PRKCQ0.77877227
72CDK30.76709294
73MARK20.75465519
74ADRBK20.74500261
75TYRO30.74087875
76DYRK1A0.70822996
77STK110.69956211
78CLK10.67821325
79LIMK10.67386305
80CAMK1G0.67028796
81WNK30.66610973
82GRK10.66407952
83ERBB20.66297416
84PLK20.65376575
85PRKG10.64394413
86ADRBK10.63272261
87CAMK10.61236203
88ERBB40.60818716
89INSRR0.60059984
90PTK2B0.59858544
91CDK140.59478373
92MAPKAPK30.59246615
93PRKACA0.55878584
94ICK0.55661651
95SGK2230.55657689
96SGK4940.55657689
97ALK0.55550259
98PLK40.54577057
99SRPK10.54526911
100BRSK20.53757880
101CSNK2A20.53311875
102CDK150.53087326
103BLK0.52077009
104FGFR10.52056806
105FYN0.51874153
106PIK3CA0.50244063
107OBSCN0.48825015
108SGK20.48804830
109CDK11A0.48708801
110CDK180.48690464
111MAP3K130.47936225
112PLK10.47728389
113PRKD10.47213605
114CHEK20.47041936
115EPHB20.46952374
116BRSK10.46727573
117MAPK120.46401943
118MKNK20.46200915
119MKNK10.45550256
120MAP3K90.45356356
121PRKCG0.45336174
122CSNK2A10.45151455
123MINK10.43590835
124SIK20.43379200
125RPS6KA30.43304637
126TLK10.43115137
127VRK10.43069426
128MAPK70.43054426
129MST1R0.42639620
130MAP2K40.42450271
131GSK3A0.41645023
132IRAK10.41260913
133PRKG20.40864936
134ARAF0.39729173
135CDK10.38192264
136BMX0.38014213
137MAP2K20.37604464
138GSK3B0.35558396
139PRKACB0.34527880
140MAPK140.32685829
141PRKDC0.32152963
142TRIB30.31768918
143AURKB0.31407223
144RPS6KA10.30721018
145MAPK100.29227521
146CSNK1A10.28965137

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.68530671
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.15752209
3Nicotine addiction_Homo sapiens_hsa050332.83023261
4Fatty acid elongation_Homo sapiens_hsa000622.71909272
5Parkinsons disease_Homo sapiens_hsa050122.71851682
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65754393
7Alzheimers disease_Homo sapiens_hsa050102.62172589
8Steroid biosynthesis_Homo sapiens_hsa001002.40628390
9Ether lipid metabolism_Homo sapiens_hsa005652.20131624
10RNA polymerase_Homo sapiens_hsa030202.10243955
11Cardiac muscle contraction_Homo sapiens_hsa042602.05985611
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05279873
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02728712
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00077352
15Glutamatergic synapse_Homo sapiens_hsa047241.99888849
16Serotonergic synapse_Homo sapiens_hsa047261.93755009
17GABAergic synapse_Homo sapiens_hsa047271.88746267
18Huntingtons disease_Homo sapiens_hsa050161.87866889
19Axon guidance_Homo sapiens_hsa043601.84112663
20Spliceosome_Homo sapiens_hsa030401.75599401
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.72023532
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66905879
23Morphine addiction_Homo sapiens_hsa050321.63153105
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63016191
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59090575
26Taste transduction_Homo sapiens_hsa047421.52121770
27Long-term depression_Homo sapiens_hsa047301.49768578
28Sphingolipid metabolism_Homo sapiens_hsa006001.46423481
29Protein export_Homo sapiens_hsa030601.43877901
30Phototransduction_Homo sapiens_hsa047441.42961576
31Collecting duct acid secretion_Homo sapiens_hsa049661.40271871
32Salivary secretion_Homo sapiens_hsa049701.35964072
33Renin secretion_Homo sapiens_hsa049241.31771070
34Circadian entrainment_Homo sapiens_hsa047131.29815107
35Nitrogen metabolism_Homo sapiens_hsa009101.29385686
36Folate biosynthesis_Homo sapiens_hsa007901.24671325
37Cocaine addiction_Homo sapiens_hsa050301.21632520
38Vitamin digestion and absorption_Homo sapiens_hsa049771.20945638
39Amphetamine addiction_Homo sapiens_hsa050311.19732551
40Linoleic acid metabolism_Homo sapiens_hsa005911.18159621
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16973121
42Proteasome_Homo sapiens_hsa030501.13758368
43Dopaminergic synapse_Homo sapiens_hsa047281.10091162
44Ribosome_Homo sapiens_hsa030101.07665619
45Phenylalanine metabolism_Homo sapiens_hsa003601.06303552
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05631922
47Chemical carcinogenesis_Homo sapiens_hsa052041.05034629
48Calcium signaling pathway_Homo sapiens_hsa040201.04896785
49Gastric acid secretion_Homo sapiens_hsa049711.04666544
50Sulfur metabolism_Homo sapiens_hsa009201.03835361
51Butanoate metabolism_Homo sapiens_hsa006501.03627923
52Homologous recombination_Homo sapiens_hsa034400.98683422
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98129559
54Histidine metabolism_Homo sapiens_hsa003400.96465804
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96013031
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95792764
57Pyruvate metabolism_Homo sapiens_hsa006200.95546923
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.95430654
59Long-term potentiation_Homo sapiens_hsa047200.93186182
60Cholinergic synapse_Homo sapiens_hsa047250.90843593
61Bile secretion_Homo sapiens_hsa049760.88577147
62One carbon pool by folate_Homo sapiens_hsa006700.85869275
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83765734
64Oxytocin signaling pathway_Homo sapiens_hsa049210.83761531
65Vibrio cholerae infection_Homo sapiens_hsa051100.80066228
66Mismatch repair_Homo sapiens_hsa034300.78653361
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77232082
68Pancreatic secretion_Homo sapiens_hsa049720.76757557
69Retinol metabolism_Homo sapiens_hsa008300.76337865
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75498837
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75222043
72Rheumatoid arthritis_Homo sapiens_hsa053230.75200292
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74350109
74Renal cell carcinoma_Homo sapiens_hsa052110.73667773
75Dorso-ventral axis formation_Homo sapiens_hsa043200.73612844
76Olfactory transduction_Homo sapiens_hsa047400.73210032
77RNA degradation_Homo sapiens_hsa030180.72494514
78Arachidonic acid metabolism_Homo sapiens_hsa005900.72195644
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71637368
80Gap junction_Homo sapiens_hsa045400.71161672
81Hedgehog signaling pathway_Homo sapiens_hsa043400.70356791
82Insulin secretion_Homo sapiens_hsa049110.70302500
83Purine metabolism_Homo sapiens_hsa002300.70253546
84Ras signaling pathway_Homo sapiens_hsa040140.69035769
85cAMP signaling pathway_Homo sapiens_hsa040240.68628860
86Ovarian steroidogenesis_Homo sapiens_hsa049130.68561243
87Basal transcription factors_Homo sapiens_hsa030220.68252545
88Synaptic vesicle cycle_Homo sapiens_hsa047210.67995260
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67017808
90Melanogenesis_Homo sapiens_hsa049160.65895558
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.65808599
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65755847
93Tryptophan metabolism_Homo sapiens_hsa003800.64811995
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63938716
95Thyroid hormone synthesis_Homo sapiens_hsa049180.63611881
96Autoimmune thyroid disease_Homo sapiens_hsa053200.62778156
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61412928
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60114493
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59857473
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59669310
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59212952
102Dilated cardiomyopathy_Homo sapiens_hsa054140.58694044
103Glutathione metabolism_Homo sapiens_hsa004800.58497033
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57701925
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54704071
106Mineral absorption_Homo sapiens_hsa049780.54697631
107Tight junction_Homo sapiens_hsa045300.53246990
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.52832775
109Fat digestion and absorption_Homo sapiens_hsa049750.52409830
110GnRH signaling pathway_Homo sapiens_hsa049120.52149711
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50791210
112Oocyte meiosis_Homo sapiens_hsa041140.50104970
113RNA transport_Homo sapiens_hsa030130.49026324
114Wnt signaling pathway_Homo sapiens_hsa043100.48694075
115Fatty acid biosynthesis_Homo sapiens_hsa000610.48581213
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48551287
117Arginine and proline metabolism_Homo sapiens_hsa003300.47593282
118DNA replication_Homo sapiens_hsa030300.47426247
119mRNA surveillance pathway_Homo sapiens_hsa030150.46842090
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46784296
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46333213
122Sulfur relay system_Homo sapiens_hsa041220.46154185
123Choline metabolism in cancer_Homo sapiens_hsa052310.46073753
124African trypanosomiasis_Homo sapiens_hsa051430.45664102
125ErbB signaling pathway_Homo sapiens_hsa040120.44810038
126ECM-receptor interaction_Homo sapiens_hsa045120.42673993
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41894165
128Nucleotide excision repair_Homo sapiens_hsa034200.41730268
129beta-Alanine metabolism_Homo sapiens_hsa004100.41008237
130Selenocompound metabolism_Homo sapiens_hsa004500.40092991
131Prion diseases_Homo sapiens_hsa050200.40023352
132Complement and coagulation cascades_Homo sapiens_hsa046100.38903731
133MAPK signaling pathway_Homo sapiens_hsa040100.38739574
134Basal cell carcinoma_Homo sapiens_hsa052170.36573727
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.35583784
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.35414041
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34616350
138Tyrosine metabolism_Homo sapiens_hsa003500.33650168
139Estrogen signaling pathway_Homo sapiens_hsa049150.33276169
140Vitamin B6 metabolism_Homo sapiens_hsa007500.32987610
141Metabolic pathways_Homo sapiens_hsa011000.32536810
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32065996
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.31922353
144Phagosome_Homo sapiens_hsa041450.31876564

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