MT-CO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.31745363
2locomotory exploration behavior (GO:0035641)6.15415365
3NADH metabolic process (GO:0006734)5.85684439
4sodium ion export (GO:0071436)5.84013360
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09317299
6cellular potassium ion homeostasis (GO:0030007)4.95458880
7layer formation in cerebral cortex (GO:0021819)4.90284566
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83219124
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.71476394
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.71125412
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.69750049
12regulation of synapse structural plasticity (GO:0051823)4.55146728
13proline biosynthetic process (GO:0006561)4.41165674
14cell communication by electrical coupling (GO:0010644)4.29314197
15glutamate secretion (GO:0014047)4.24340493
16activation of protein kinase A activity (GO:0034199)4.21855599
17oxaloacetate metabolic process (GO:0006107)4.20899801
18Golgi transport vesicle coating (GO:0048200)4.13802084
19COPI coating of Golgi vesicle (GO:0048205)4.13802084
20potassium ion import (GO:0010107)4.09224596
21vocalization behavior (GO:0071625)4.01089294
22exploration behavior (GO:0035640)3.96653290
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90415447
24neurotransmitter secretion (GO:0007269)3.85331071
25regulation of glutamate receptor signaling pathway (GO:1900449)3.84980551
26regulation of synaptic vesicle exocytosis (GO:2000300)3.83581206
27cellular sodium ion homeostasis (GO:0006883)3.81595010
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.80343785
29establishment of nucleus localization (GO:0040023)3.73942268
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70467001
31synaptic vesicle exocytosis (GO:0016079)3.70328778
32proline metabolic process (GO:0006560)3.68939207
33cell communication involved in cardiac conduction (GO:0086065)3.66791184
34regulation of neuronal synaptic plasticity (GO:0048168)3.63760167
35proline transport (GO:0015824)3.60765354
36regulation of ARF protein signal transduction (GO:0032012)3.60330542
37vitamin transmembrane transport (GO:0035461)3.59223196
38neuromuscular process controlling balance (GO:0050885)3.58308277
39glycine transport (GO:0015816)3.51990023
40regulation of mitotic spindle organization (GO:0060236)3.51523115
41dendritic spine morphogenesis (GO:0060997)3.50257214
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40386709
43regulation of synaptic vesicle transport (GO:1902803)3.39428548
44gamma-aminobutyric acid transport (GO:0015812)3.39168117
45lysine metabolic process (GO:0006553)3.33807270
46lysine catabolic process (GO:0006554)3.33807270
47potassium ion homeostasis (GO:0055075)3.32732428
48gluconeogenesis (GO:0006094)3.31170820
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30432161
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29259141
51creatine metabolic process (GO:0006600)3.25947543
52regulation of dendritic spine morphogenesis (GO:0061001)3.25770213
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.24787865
54peptidyl-lysine dimethylation (GO:0018027)3.22397429
55regulation of clathrin-mediated endocytosis (GO:2000369)3.20006510
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19666807
57prepulse inhibition (GO:0060134)3.19436820
58protein retention in ER lumen (GO:0006621)3.17983995
59glutamine family amino acid biosynthetic process (GO:0009084)3.16685035
60maternal placenta development (GO:0001893)3.16048504
61neuronal action potential propagation (GO:0019227)3.14856060
62regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14093360
63tricarboxylic acid cycle (GO:0006099)3.09708801
64cell volume homeostasis (GO:0006884)3.09037926
65hexose biosynthetic process (GO:0019319)3.07467936
66fructose metabolic process (GO:0006000)3.07136228
67long-term memory (GO:0007616)3.05879355
68positive regulation of membrane potential (GO:0045838)3.00884730
69membrane repolarization (GO:0086009)3.00293850
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00249248
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00227419
72negative regulation of mRNA processing (GO:0050686)2.99936724
73plasma membrane repair (GO:0001778)2.96683724
74hyperosmotic salinity response (GO:0042538)2.96429894
75monosaccharide biosynthetic process (GO:0046364)2.96054494
76desmosome organization (GO:0002934)2.94963649
77amino acid import (GO:0043090)2.94903106
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.90451744
79carnitine shuttle (GO:0006853)2.88744606
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87171386
81clathrin coat assembly (GO:0048268)2.86304639
82adenine nucleotide transport (GO:0051503)2.86013710
83cellular hyperosmotic response (GO:0071474)2.85915374
84tricarboxylic acid metabolic process (GO:0072350)2.85544504
85neurotransmitter-gated ion channel clustering (GO:0072578)2.84189704
86neurotransmitter transport (GO:0006836)2.83990199
87positive regulation of synapse maturation (GO:0090129)2.83186542
88vesicle transport along microtubule (GO:0047496)2.82177374
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82153988
90activation of Rac GTPase activity (GO:0032863)2.82027403
91dicarboxylic acid biosynthetic process (GO:0043650)2.81219733
92regulation of cholesterol biosynthetic process (GO:0045540)2.80827638
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78726984
94auditory behavior (GO:0031223)2.77874557
95adherens junction assembly (GO:0034333)2.77591432
96negative regulation of sodium ion transport (GO:0010766)2.77469094
97phosphate ion transmembrane transport (GO:0035435)2.77139810
98negative regulation of cell size (GO:0045792)2.77114500
99regulation of ARF GTPase activity (GO:0032312)2.76939847
100alanine transport (GO:0032328)2.76869881
101DNA unwinding involved in DNA replication (GO:0006268)2.76622841
102phosphate ion transport (GO:0006817)2.75462613
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.75393921
104neuromuscular process controlling posture (GO:0050884)2.75101986
105negative regulation of potassium ion transmembrane transport (GO:1901380)2.74830642
106negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74750050
107protein localization to synapse (GO:0035418)2.73857565
108aspartate family amino acid catabolic process (GO:0009068)2.72860132
109cerebellar Purkinje cell differentiation (GO:0021702)2.71632168
110glucose 6-phosphate metabolic process (GO:0051156)2.71627606
111regulation of cholesterol metabolic process (GO:0090181)2.71201884
112cAMP biosynthetic process (GO:0006171)2.70881330
113regulation of cholesterol homeostasis (GO:2000188)2.70480411
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.69516747
115dendrite morphogenesis (GO:0048813)2.68875958
116carnitine transport (GO:0015879)2.67926480
117amino-acid betaine transport (GO:0015838)2.67926480
118regulation of early endosome to late endosome transport (GO:2000641)2.67459812
119glial cell proliferation (GO:0014009)2.67437945
120purine nucleotide transport (GO:0015865)2.67431748
121membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.67226321
122regulation of neurotransmitter levels (GO:0001505)2.66647474
123mitotic chromosome condensation (GO:0007076)2.66541262
124negative regulation of mRNA metabolic process (GO:1903312)2.64117366
1252-oxoglutarate metabolic process (GO:0006103)2.64061993
126regulation of histone H3-K27 methylation (GO:0061085)2.63494500
127cardiac muscle contraction (GO:0060048)2.63305802
128L-amino acid import (GO:0043092)2.63058096
129succinate metabolic process (GO:0006105)2.62356071
130regulation of ion transmembrane transporter activity (GO:0032412)2.60934680
131regulation of translational fidelity (GO:0006450)2.60745945
132membrane depolarization during action potential (GO:0086010)2.59973264
133CDP-diacylglycerol biosynthetic process (GO:0016024)2.58915333
134carnitine transmembrane transport (GO:1902603)2.58780467
135regulation of bile acid biosynthetic process (GO:0070857)2.58158813
136positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.57803500
137regulation of calcium ion transmembrane transport (GO:1903169)2.57481916
138regulation of calcium ion transmembrane transporter activity (GO:1901019)2.57481916
139positive regulation of cellular amine metabolic process (GO:0033240)2.57252297
140cellular response to epidermal growth factor stimulus (GO:0071364)2.56478051
141regulation of synaptic plasticity (GO:0048167)2.56096742
142ethanol oxidation (GO:0006069)2.56081666
143regulation of synapse maturation (GO:0090128)2.55939768
144glycolytic process (GO:0006096)2.55531062
145cell-substrate adherens junction assembly (GO:0007045)2.52906279
146focal adhesion assembly (GO:0048041)2.52906279
147dendritic spine organization (GO:0097061)2.52048613
148lung epithelium development (GO:0060428)2.51942835
149regulation of transmembrane transporter activity (GO:0022898)2.50387247
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.50183614
151positive regulation of nuclease activity (GO:0032075)2.46408155
152activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44001216
153regulation of spindle organization (GO:0090224)2.43970030
154regulation of protein dephosphorylation (GO:0035304)2.42900790
155spliceosomal tri-snRNP complex assembly (GO:0000244)2.39558160
156ethanol metabolic process (GO:0006067)2.38700847
157urea cycle (GO:0000050)2.38626245
158negative regulation of erythrocyte differentiation (GO:0045647)2.36775968
159cerebellar granule cell differentiation (GO:0021707)2.35152898
160stress granule assembly (GO:0034063)2.34712405
161fatty acid homeostasis (GO:0055089)2.31818091
162negative regulation of dendrite morphogenesis (GO:0050774)2.29557172
163NADPH regeneration (GO:0006740)2.29057384
164cellular response to nitric oxide (GO:0071732)2.29035167
165regulation of mammary gland epithelial cell proliferation (GO:0033599)2.28212966
166mRNA polyadenylation (GO:0006378)2.27578669
167sodium ion homeostasis (GO:0055078)2.26879887
168neutral lipid catabolic process (GO:0046461)2.25130433
169acylglycerol catabolic process (GO:0046464)2.25130433
170actin filament depolymerization (GO:0030042)2.23216785
171positive regulation of protein dephosphorylation (GO:0035307)2.23053488
172positive regulation of dendritic spine morphogenesis (GO:0061003)2.22690341
173protein complex localization (GO:0031503)2.22646185
174urea metabolic process (GO:0019627)2.21846934
175cellular protein complex localization (GO:0034629)2.21185870
176negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.20730260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.55931444
2E2F7_22180533_ChIP-Seq_HELA_Human3.49420623
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.06027157
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.99661111
5ZNF263_19887448_ChIP-Seq_K562_Human2.98713875
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.98070758
7DROSHA_22980978_ChIP-Seq_HELA_Human2.80167720
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38283026
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22775341
10KDM2B_26808549_Chip-Seq_DND41_Human2.19146004
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18823599
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.18123503
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15616895
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12418399
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11426707
16DNAJC2_21179169_ChIP-ChIP_NT2_Human2.04138009
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97487294
18EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.94710800
19KDM2B_26808549_Chip-Seq_K562_Human1.94569717
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.91600410
21MYC_22102868_ChIP-Seq_BL_Human1.89343617
22AR_21909140_ChIP-Seq_LNCAP_Human1.86890791
23TCF7_22412390_ChIP-Seq_EML_Mouse1.85926036
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80919994
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79144197
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.78514629
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78319339
28REST_21632747_ChIP-Seq_MESCs_Mouse1.74954461
29LXR_22292898_ChIP-Seq_THP-1_Human1.74312685
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73368534
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73368534
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72911647
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.71494695
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.69832067
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69784665
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68152860
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68056986
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67317231
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.66200555
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65628328
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64991102
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.64563605
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62808546
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62739329
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61884001
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60988094
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60794147
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60630446
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57762418
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57071775
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52742929
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51877518
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48704654
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47416723
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.46726923
56TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46096488
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45751361
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.43671743
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43227964
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.42526344
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42351314
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41083976
63ZNF274_21170338_ChIP-Seq_K562_Hela1.39516501
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37693736
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36145131
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.34757200
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34188537
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33958961
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32528996
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.31475259
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30708152
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29696973
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.28971103
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27471813
75CREB1_26743006_Chip-Seq_LNCaP_Human1.26997258
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26877240
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.26710397
78SMC4_20622854_ChIP-Seq_HELA_Human1.25808857
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25161770
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24488634
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23464222
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.23100246
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.22531770
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20362167
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20220081
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20206034
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19174545
88GATA1_19941826_ChIP-Seq_K562_Human1.18940869
89P68_20966046_ChIP-Seq_HELA_Human1.18865998
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18265211
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17931910
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17429504
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.17406987
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.16419510
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15793268
96GATA1_22025678_ChIP-Seq_K562_Human1.15365512
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14229821
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13273767
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.12983652
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.12983652
101RACK7_27058665_Chip-Seq_MCF-7_Human1.12894022
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12745885
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.12500586
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.12357270
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10866587
106TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.10230736
107CTCF_27219007_Chip-Seq_Bcells_Human1.09817079
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09767642
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09475804
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09469674
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09284567
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08964493
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08390140
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08216083
115ETS1_21867929_ChIP-Seq_TH2_Mouse1.06838504
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06561436
117SCL_19346495_ChIP-Seq_HPC-7_Human1.06431245
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05976560
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.05661754
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.05138740
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05080640
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05050591
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04839980
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03858729
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03512303
126RUNX1_27514584_Chip-Seq_MCF-7_Human1.02659653
127GATA1_19941827_ChIP-Seq_MEL_Mouse1.02539064
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02090448
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01928922
130KLF4_19829295_ChIP-Seq_ESCs_Human1.01597153
131NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01565480
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.00515672
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00073545
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99650957
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.99275788
136FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98496481
137MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98330902
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98320616
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.98120115
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.98049507
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97855314
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97555570
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97196551
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96627683
145AR_21572438_ChIP-Seq_LNCaP_Human0.96373407
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96230672
147EP300_21415370_ChIP-Seq_HL-1_Mouse0.93826960
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93772715
149AR_19668381_ChIP-Seq_PC3_Human0.91974065
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91131790
151SMAD4_21741376_ChIP-Seq_ESCs_Human0.90299771
152CLOCK_20551151_ChIP-Seq_293T_Human0.89704833
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89636962
154SOX2_21211035_ChIP-Seq_LN229_Gbm0.89234074
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.89036161
156TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88710505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.68265140
2MP0002822_catalepsy3.49283560
3MP0003635_abnormal_synaptic_transmissio3.39930544
4MP0010234_abnormal_vibrissa_follicle3.37355034
5MP0004270_analgesia2.82070465
6MP0000566_synostosis2.64017878
7MP0009780_abnormal_chondrocyte_physiolo2.48481393
8MP0004885_abnormal_endolymph2.46850251
9MP0004130_abnormal_muscle_cell2.46426117
10MP0002063_abnormal_learning/memory/cond2.42519005
11MP0008961_abnormal_basal_metabolism2.40032647
12MP0009745_abnormal_behavioral_response2.35732289
13MP0008569_lethality_at_weaning2.28495497
14MP0009672_abnormal_birth_weight2.22694854
15MP0005670_abnormal_white_adipose2.19901237
16MP0002909_abnormal_adrenal_gland2.11720077
17MP0005409_darkened_coat_color2.11316781
18MP0003329_amyloid_beta_deposits2.05616387
19MP0005167_abnormal_blood-brain_barrier2.04457089
20MP0002064_seizures2.02318431
21MP0004084_abnormal_cardiac_muscle1.98616702
22MP0005423_abnormal_somatic_nervous1.96154924
23MP0003111_abnormal_nucleus_morphology1.94545313
24MP0004043_abnormal_pH_regulation1.93981424
25MP0004782_abnormal_surfactant_physiolog1.91881481
26MP0004264_abnormal_extraembryonic_tissu1.91231849
27MP0009046_muscle_twitch1.89670151
28MP0003123_paternal_imprinting1.88892592
29MP0003693_abnormal_embryo_hatching1.81982111
30MP0005451_abnormal_body_composition1.80992730
31MP0000678_abnormal_parathyroid_gland1.78601444
32MP0000747_muscle_weakness1.75088513
33MP0001730_embryonic_growth_arrest1.73375988
34* MP0004215_abnormal_myocardial_fiber1.73140159
35MP0002249_abnormal_larynx_morphology1.73009551
36MP0003879_abnormal_hair_cell1.72761231
37MP0001486_abnormal_startle_reflex1.69177549
38MP0004858_abnormal_nervous_system1.66365006
39MP0003880_abnormal_central_pattern1.63991460
40MP0005360_urolithiasis1.62181623
41MP0002272_abnormal_nervous_system1.62116686
42MP0003172_abnormal_lysosome_physiology1.60934215
43MP0002139_abnormal_hepatobiliary_system1.60104572
44MP0001346_abnormal_lacrimal_gland1.59849483
45MP0002396_abnormal_hematopoietic_system1.58901645
46MP0004036_abnormal_muscle_relaxation1.58359675
47MP0010094_abnormal_chromosome_stability1.56134335
48MP0002796_impaired_skin_barrier1.55031801
49MP0003646_muscle_fatigue1.53006649
50MP0002572_abnormal_emotion/affect_behav1.51631266
51MP0004811_abnormal_neuron_physiology1.49838502
52MP0005187_abnormal_penis_morphology1.47626526
53MP0003300_gastrointestinal_ulcer1.47270366
54MP0002089_abnormal_postnatal_growth/wei1.46619371
55MP0001666_abnormal_nutrient_absorption1.43428584
56MP0005058_abnormal_lysosome_morphology1.43234824
57MP0003705_abnormal_hypodermis_morpholog1.42779016
58MP0004957_abnormal_blastocyst_morpholog1.42662587
59* MP0000751_myopathy1.41017084
60MP0002734_abnormal_mechanical_nocicepti1.37112007
61MP0003633_abnormal_nervous_system1.35963890
62MP0001501_abnormal_sleep_pattern1.32990501
63* MP0006036_abnormal_mitochondrial_physio1.32865021
64MP0003283_abnormal_digestive_organ1.31639094
65* MP0004087_abnormal_muscle_fiber1.28151828
66MP0003075_altered_response_to1.27448274
67MP0008872_abnormal_physiological_respon1.26496862
68MP0001968_abnormal_touch/_nociception1.26056765
69MP0005076_abnormal_cell_differentiation1.25883688
70MP0004145_abnormal_muscle_electrophysio1.25648791
71MP0004484_altered_response_of1.23491839
72MP0000579_abnormal_nail_morphology1.22062353
73MP0004147_increased_porphyrin_level1.21636894
74MP0005666_abnormal_adipose_tissue1.21629055
75MP0005365_abnormal_bile_salt1.21212297
76MP0005623_abnormal_meninges_morphology1.20744636
77MP0004233_abnormal_muscle_weight1.19777385
78MP0004924_abnormal_behavior1.15987821
79MP0005386_behavior/neurological_phenoty1.15987821
80MP0008260_abnormal_autophagy1.15686783
81MP0003566_abnormal_cell_adhesion1.15505818
82MP0000569_abnormal_digit_pigmentation1.14135046
83MP0004019_abnormal_vitamin_homeostasis1.12325557
84MP0001440_abnormal_grooming_behavior1.11579005
85MP0000350_abnormal_cell_proliferation1.07802751
86MP0001348_abnormal_lacrimal_gland1.05399079
87MP0005584_abnormal_enzyme/coenzyme_acti1.05021211
88MP0008874_decreased_physiological_sensi1.03938677
89MP0002080_prenatal_lethality1.02801762
90MP0001502_abnormal_circadian_rhythm1.02670204
91MP0002269_muscular_atrophy1.02656565
92MP0005620_abnormal_muscle_contractility1.02512228
93MP0002234_abnormal_pharynx_morphology1.02247444
94MP0003868_abnormal_feces_composition1.02031497
95MP0003690_abnormal_glial_cell1.01547187
96MP0002837_dystrophic_cardiac_calcinosis1.00582299
97MP0002970_abnormal_white_adipose1.00098354
98MP0004085_abnormal_heartbeat0.99305029
99MP0003878_abnormal_ear_physiology0.99242395
100MP0005377_hearing/vestibular/ear_phenot0.99242395
101MP0002067_abnormal_sensory_capabilities0.98903814
102MP0005501_abnormal_skin_physiology0.98612762
103MP0008932_abnormal_embryonic_tissue0.98438820
104MP0002066_abnormal_motor_capabilities/c0.98410077
105MP0002971_abnormal_brown_adipose0.97930460
106MP0003631_nervous_system_phenotype0.97380151
107MP0002557_abnormal_social/conspecific_i0.97160842
108MP0000955_abnormal_spinal_cord0.96673324
109MP0001672_abnormal_embryogenesis/_devel0.96453461
110MP0005380_embryogenesis_phenotype0.96453461
111MP0005535_abnormal_body_temperature0.95059347
112MP0006138_congestive_heart_failure0.94982750
113MP0003137_abnormal_impulse_conducting0.93985635
114MP0002733_abnormal_thermal_nociception0.93674565
115* MP0010630_abnormal_cardiac_muscle0.92795187
116MP0005375_adipose_tissue_phenotype0.92682609
117MP0005385_cardiovascular_system_phenoty0.91380643
118MP0001544_abnormal_cardiovascular_syste0.91380643
119MP0001765_abnormal_ion_homeostasis0.90709691
120MP0000462_abnormal_digestive_system0.87673391
121* MP0005330_cardiomyopathy0.87306737
122MP0004185_abnormal_adipocyte_glucose0.87110839
123MP0000604_amyloidosis0.86611715
124MP0002972_abnormal_cardiac_muscle0.86393361
125MP0003984_embryonic_growth_retardation0.85748654
126MP0000467_abnormal_esophagus_morphology0.84410585
127MP0001849_ear_inflammation0.84399500
128MP0009703_decreased_birth_body0.84035592
129MP0003077_abnormal_cell_cycle0.83440050
130MP0000013_abnormal_adipose_tissue0.82160068
131MP0010352_gastrointestinal_tract_polyps0.81762940
132MP0009840_abnormal_foam_cell0.80603485
133MP0002184_abnormal_innervation0.79864721
134MP0001970_abnormal_pain_threshold0.79809347
135MP0002088_abnormal_embryonic_growth/wei0.79378656
136MP0003122_maternal_imprinting0.79148335
137MP0001661_extended_life_span0.79136510
138MP0001697_abnormal_embryo_size0.78919754
139MP0002118_abnormal_lipid_homeostasis0.77704413
140MP0010329_abnormal_lipoprotein_level0.77662489
141MP0000537_abnormal_urethra_morphology0.76964576
142* MP0002106_abnormal_muscle_physiology0.76105692
143MP0002098_abnormal_vibrissa_morphology0.75862186
144MP0000003_abnormal_adipose_tissue0.75187507
145MP0003221_abnormal_cardiomyocyte_apopto0.74556267
146MP0002152_abnormal_brain_morphology0.74193922
147MP0005332_abnormal_amino_acid0.72998486
148MP0005166_decreased_susceptibility_to0.72390126
149MP0001177_atelectasis0.72071995
150MP0002882_abnormal_neuron_morphology0.70854488
151MP0005621_abnormal_cell_physiology0.70574020
152MP0010678_abnormal_skin_adnexa0.69293762
153MP0000759_abnormal_skeletal_muscle0.69250989
154MP0002069_abnormal_eating/drinking_beha0.68968589
155MP0000920_abnormal_myelination0.68140322
156MP0009643_abnormal_urine_homeostasis0.67740785
157MP0000477_abnormal_intestine_morphology0.67394543
158MP0003115_abnormal_respiratory_system0.66955208
159MP0001881_abnormal_mammary_gland0.66207614
160MP0003183_abnormal_peptide_metabolism0.66128107

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.80206506
2Visual hallucinations (HP:0002367)4.17844319
3Cholecystitis (HP:0001082)3.68088904
4Abnormal gallbladder physiology (HP:0012438)3.68088904
5Papilledema (HP:0001085)3.61028406
6Abnormality of glycolysis (HP:0004366)3.49599518
7Ventricular fibrillation (HP:0001663)3.37107086
8Bundle branch block (HP:0011710)3.34552288
9Focal motor seizures (HP:0011153)3.32359792
10Exercise-induced myalgia (HP:0003738)3.31413014
11Ankle clonus (HP:0011448)3.26149110
12Action tremor (HP:0002345)3.23359911
13Abnormality of the lower motor neuron (HP:0002366)3.22162515
14Abnormal social behavior (HP:0012433)3.21582539
15Impaired social interactions (HP:0000735)3.21582539
16Impaired vibration sensation in the lower limbs (HP:0002166)3.20786984
17Obstructive sleep apnea (HP:0002870)3.15327232
18Poor eye contact (HP:0000817)3.13135513
19Dysmetric saccades (HP:0000641)3.11795609
20Exercise-induced muscle cramps (HP:0003710)3.11723689
21Hyperacusis (HP:0010780)3.08807848
22Urinary urgency (HP:0000012)3.07285412
23Focal seizures (HP:0007359)3.05992653
24Insomnia (HP:0100785)2.95944923
25Postural instability (HP:0002172)2.95483528
26Depression (HP:0000716)2.93668701
27Deep venous thrombosis (HP:0002625)2.93608204
28Myoglobinuria (HP:0002913)2.77832440
29Increased serum pyruvate (HP:0003542)2.75027427
30Hemiplegia (HP:0002301)2.74173864
31Difficulty running (HP:0009046)2.73530031
32Elfin facies (HP:0004428)2.71255317
33Annular pancreas (HP:0001734)2.65418897
34Stridor (HP:0010307)2.62895089
35Increased nuchal translucency (HP:0010880)2.59510959
36Right ventricular cardiomyopathy (HP:0011663)2.57771936
37Pointed chin (HP:0000307)2.57253703
38Urinary bladder sphincter dysfunction (HP:0002839)2.57012859
39Intention tremor (HP:0002080)2.55563288
40Resting tremor (HP:0002322)2.54146242
41Ankyloglossia (HP:0010296)2.52870348
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.50584708
43Myopathic facies (HP:0002058)2.49484645
44Macroorchidism (HP:0000053)2.49246587
45Bronchomalacia (HP:0002780)2.45365391
46Dysdiadochokinesis (HP:0002075)2.42857937
47Growth hormone excess (HP:0000845)2.41745616
48Atrioventricular block (HP:0001678)2.40941518
49Sudden death (HP:0001699)2.38391797
50Heart block (HP:0012722)2.32509658
51Increased circulating renin level (HP:0000848)2.32440912
52Supranuclear gaze palsy (HP:0000605)2.28828557
53Abnormality of the salivary glands (HP:0010286)2.25284538
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23363551
55Gout (HP:0001997)2.20685207
56Urethral obstruction (HP:0000796)2.18455285
57Anxiety (HP:0000739)2.18262954
58Distal lower limb muscle weakness (HP:0009053)2.17877879
59Tetraplegia (HP:0002445)2.16823189
60Hyporeflexia of lower limbs (HP:0002600)2.16195825
61Pili torti (HP:0003777)2.15295236
62Enlarged penis (HP:0000040)2.11828418
63Termporal pattern (HP:0011008)2.11172190
64Insidious onset (HP:0003587)2.11172190
65Overriding aorta (HP:0002623)2.11079754
66Hyperglycinuria (HP:0003108)2.10250229
67Torticollis (HP:0000473)2.09674549
68Mutism (HP:0002300)2.08670951
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07924867
70Hand muscle atrophy (HP:0009130)2.07496491
71Impaired smooth pursuit (HP:0007772)2.07185890
72Muscle stiffness (HP:0003552)2.05880873
73Distal upper limb amyotrophy (HP:0007149)2.05314933
74Upper limb amyotrophy (HP:0009129)2.05314933
75Hypokalemic alkalosis (HP:0001949)2.05152981
76Abnormality of ocular smooth pursuit (HP:0000617)2.04817262
77Abnormality of oral frenula (HP:0000190)2.03738580
78Progressive cerebellar ataxia (HP:0002073)2.03587925
79Broad-based gait (HP:0002136)2.02560854
80Cerebral aneurysm (HP:0004944)2.01721941
81Cerebral hypomyelination (HP:0006808)2.01113360
82Ragged-red muscle fibers (HP:0003200)2.00622819
83Hemorrhage of the eye (HP:0011885)2.00619932
84Neuronal loss in central nervous system (HP:0002529)2.00405019
85Metabolic alkalosis (HP:0200114)2.00386887
86Abnormal atrioventricular conduction (HP:0005150)1.98683137
87Bradykinesia (HP:0002067)1.97634074
88Dysmetria (HP:0001310)1.97491756
89Impaired vibratory sensation (HP:0002495)1.97184018
90Spastic gait (HP:0002064)1.97041771
91Intellectual disability, profound (HP:0002187)1.96689572
92Generalized tonic-clonic seizures (HP:0002069)1.96237508
93Turricephaly (HP:0000262)1.95511466
94Lymphangioma (HP:0100764)1.95453312
95Distal lower limb amyotrophy (HP:0008944)1.95324763
96Abnormal eating behavior (HP:0100738)1.95053039
97Megalencephaly (HP:0001355)1.94362077
98Clonus (HP:0002169)1.93713971
99Renovascular hypertension (HP:0100817)1.93607242
100Ventricular arrhythmia (HP:0004308)1.93412587
101Obsessive-compulsive behavior (HP:0000722)1.93030075
102Truncal ataxia (HP:0002078)1.92939334
103Focal dystonia (HP:0004373)1.92394674
104Hyperactive renin-angiotensin system (HP:0000841)1.92173362
105Gaze-evoked nystagmus (HP:0000640)1.92146102
106Neonatal death (HP:0003811)1.91637959
107Neonatal onset (HP:0003623)1.91570294
108Easy fatigability (HP:0003388)1.91211723
109Absence seizures (HP:0002121)1.90732323
110Rhabdomyolysis (HP:0003201)1.89179062
111Scanning speech (HP:0002168)1.88645590
112Stereotypic behavior (HP:0000733)1.88455651
113Hammertoe (HP:0001765)1.87211220
114Foot dorsiflexor weakness (HP:0009027)1.87153594
115Genetic anticipation (HP:0003743)1.86996554
116Hypoglycemic seizures (HP:0002173)1.85839303
117Peripheral hypomyelination (HP:0007182)1.85191074
118Hypobetalipoproteinemia (HP:0003563)1.84868270
119Akinesia (HP:0002304)1.84825879
120Visceral angiomatosis (HP:0100761)1.83887695
121Abnormality of the foot musculature (HP:0001436)1.83524715
122Amyotrophic lateral sclerosis (HP:0007354)1.83128896
123Achilles tendon contracture (HP:0001771)1.82968997
124Truncus arteriosus (HP:0001660)1.82655323
125Abnormality of the Achilles tendon (HP:0005109)1.82430125
126Lower limb asymmetry (HP:0100559)1.80694092
127Myotonia (HP:0002486)1.80546613
128Ketoacidosis (HP:0001993)1.80244510
129Flat acetabular roof (HP:0003180)1.79374775
130Hypercholesterolemia (HP:0003124)1.78942439
131Neurofibrillary tangles (HP:0002185)1.78026056
132Alacrima (HP:0000522)1.77455880
133Mildly elevated creatine phosphokinase (HP:0008180)1.76955294
134Microvesicular hepatic steatosis (HP:0001414)1.76703682
135Craniofacial dystonia (HP:0012179)1.76272372
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75281797
137Reticulocytosis (HP:0001923)1.75125156
138Fibroma (HP:0010614)1.74204055
139Frequent falls (HP:0002359)1.73278237
140Lower limb amyotrophy (HP:0007210)1.73021048
141Abnormality of saccadic eye movements (HP:0000570)1.72524702
142Polygenic inheritance (HP:0010982)1.72413983
143Subacute progressive viral hepatitis (HP:0006572)1.72349803
144Rapidly progressive (HP:0003678)1.72272857
145Abnormality of the astrocytes (HP:0100707)1.72205408
146Astrocytoma (HP:0009592)1.72205408
147Increased variability in muscle fiber diameter (HP:0003557)1.72124718
148Prolonged QT interval (HP:0001657)1.71287641
149Limb-girdle muscle atrophy (HP:0003797)1.71236763
150Abnormal EKG (HP:0003115)1.70513081
151Subaortic stenosis (HP:0001682)1.70366050
152Polar cataract (HP:0010696)1.69711267
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69492483
154Hyperparathyroidism (HP:0000843)1.68587547
155Broad palm (HP:0001169)1.68378813
156Vertebral compression fractures (HP:0002953)1.67686456
157Hypoglycemic coma (HP:0001325)1.67625533
158Impaired pain sensation (HP:0007328)1.67315321
159Abnormality of pain sensation (HP:0010832)1.67315321
160Hyperphosphatemia (HP:0002905)1.66635237
161Hypokinesia (HP:0002375)1.66524656
162Advanced eruption of teeth (HP:0006288)1.66392126
163Cholelithiasis (HP:0001081)1.65722742
164Seborrheic dermatitis (HP:0001051)1.64817952
165Progressive external ophthalmoplegia (HP:0000590)1.63183130
166Hyperinsulinemic hypoglycemia (HP:0000825)1.62640647
167Back pain (HP:0003418)1.62160180
168Hemangiomatosis (HP:0007461)1.61987230
169Athetosis (HP:0002305)1.61750049
170Acanthosis nigricans (HP:0000956)1.61015354
171Abnormal gallbladder morphology (HP:0012437)1.60304028
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59847393
173Abnormal cartilage morphology (HP:0002763)1.59674338
174Shallow orbits (HP:0000586)1.58922274
175Hypercortisolism (HP:0001578)1.58823055
176Pterygium (HP:0001059)1.58434305
177Increased connective tissue (HP:0009025)1.58307752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.24143707
2MAP3K93.19879683
3TRIB33.07353034
4PKN22.87309829
5EPHA22.85240631
6NEK12.75948934
7PRKD32.61175865
8PRPF4B2.60964472
9KSR22.60417509
10FGFR42.47411905
11NTRK32.46829483
12MST1R2.41019112
13EPHA42.38917813
14RIPK12.35803097
15CAMKK12.34336554
16LMTK22.18721471
17PAK61.99791016
18SCYL21.99687757
19EEF2K1.92572134
20ERN11.91006968
21DAPK21.85281929
22MINK11.81862204
23EIF2AK11.81695756
24PDK41.79725863
25PDK31.79725863
26TAOK11.76703881
27MAP3K41.74757391
28MARK11.73613419
29TTK1.63255294
30CDK121.63236420
31LATS21.61513701
32TESK11.59982895
33STK381.56360350
34TYRO31.56025125
35MAP3K21.49655650
36MAP3K71.45943180
37ALK1.45651374
38NTRK21.41518565
39MAP2K41.40841410
40PHKG21.39673199
41PHKG11.39673199
42SIK31.38902474
43RET1.38143298
44CDK191.35133549
45NME11.31335709
46SIK21.23583870
47PAK41.22452690
48MET1.21148460
49KSR11.20423929
50NEK61.19365541
51BUB11.14748481
52TTN1.14254147
53CAMK11.08831816
54MAPKAPK31.08444918
55PRKCH1.07211823
56PTK21.07146127
57CDK51.06948657
58LRRK21.06606517
59PDK11.05203432
60STK111.04728003
61NTRK11.03797379
62TNIK0.97035295
63CAMK1G0.96596779
64DMPK0.93590702
65PTK60.92222364
66MAP3K130.90218614
67DAPK10.90150044
68PBK0.89999426
69RAF10.88090857
70MST40.86464207
71CAMKK20.82138422
72WNK40.80034721
73PDGFRA0.78696193
74WNK10.76642652
75ARAF0.75946825
76NME20.75580908
77PINK10.75313492
78PDPK10.74732800
79VRK20.74234979
80PAK30.73817361
81CAMK1D0.73738625
82ICK0.73633853
83MTOR0.73534697
84BRSK10.73450008
85SGK30.70953479
86FGFR20.65580391
87CDK70.65308281
88BRD40.64141769
89MAP3K10.62665033
90MAP3K80.61043772
91MAP2K70.60827421
92MAPK110.59259338
93MAP3K100.59232595
94FES0.57093546
95OXSR10.57076562
96RPS6KB20.56799258
97CDK90.56056416
98FER0.56036597
99LIMK10.55300887
100UHMK10.54214925
101PDK20.52502265
102MAP2K60.52019026
103AKT20.51397496
104MARK20.48805545
105RPS6KA30.48505183
106CDK150.47728949
107WNK30.47225768
108PRKCI0.47015298
109RIPK40.47009459
110CHEK10.46822517
111CDK40.46716918
112CSNK1G20.44788323
113CDK11A0.44501804
114TNK20.43245358
115JAK20.42485199
116MUSK0.42049312
117PRKCG0.42013257
118BMX0.42007228
119SGK10.41973013
120TSSK60.41329172
121CAMK2G0.41026276
122PTK2B0.40718756
123EPHB10.40423617
124PRKD10.40376645
125CDK60.40290801
126CDK180.40238838
127CDK10.39366992
128WEE10.39054947
129MAP2K10.38566066
130PRKG20.38290056
131CDK140.38021660
132FYN0.37754076
133SIK10.37530150
134CAMK40.37352256
135MAPK100.37137352
136CDK20.37031340
137CDC42BPA0.36982943
138NEK20.36763688
139MAP2K30.36633713
140FGFR30.36256168
141FLT30.36219573
142MAPK120.35992011
143CAMK2B0.35985381
144PRKAA10.34979128
145PAK20.34138021
146FGFR10.33910065
147SGK2230.33559088

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.49058504
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66041409
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.48203672
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35973234
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20826181
6Vitamin B6 metabolism_Homo sapiens_hsa007502.20348002
7Olfactory transduction_Homo sapiens_hsa047402.12887807
8Long-term potentiation_Homo sapiens_hsa047202.02834913
9Gastric acid secretion_Homo sapiens_hsa049711.94978953
10Circadian entrainment_Homo sapiens_hsa047131.92331677
11Fructose and mannose metabolism_Homo sapiens_hsa000511.92091250
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77466279
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76191678
14Pentose phosphate pathway_Homo sapiens_hsa000301.75827787
15Phenylalanine metabolism_Homo sapiens_hsa003601.70808783
16Fatty acid elongation_Homo sapiens_hsa000621.70582489
17Salivary secretion_Homo sapiens_hsa049701.70430192
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69789189
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66496785
20Glutamatergic synapse_Homo sapiens_hsa047241.64572039
21Arginine and proline metabolism_Homo sapiens_hsa003301.63180174
22Synaptic vesicle cycle_Homo sapiens_hsa047211.62126927
23GABAergic synapse_Homo sapiens_hsa047271.61399121
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58250493
25Amphetamine addiction_Homo sapiens_hsa050311.50840324
26Bile secretion_Homo sapiens_hsa049761.50265266
27Nicotine addiction_Homo sapiens_hsa050331.46819652
28Oxytocin signaling pathway_Homo sapiens_hsa049211.44964157
29Histidine metabolism_Homo sapiens_hsa003401.44339228
30Morphine addiction_Homo sapiens_hsa050321.42169494
31Dopaminergic synapse_Homo sapiens_hsa047281.38860917
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34404355
33Insulin secretion_Homo sapiens_hsa049111.32235357
34Renin secretion_Homo sapiens_hsa049241.31657645
35Fatty acid degradation_Homo sapiens_hsa000711.31276437
36Cholinergic synapse_Homo sapiens_hsa047251.29298491
37GnRH signaling pathway_Homo sapiens_hsa049121.23386475
38Propanoate metabolism_Homo sapiens_hsa006401.22234834
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21908082
40Arginine biosynthesis_Homo sapiens_hsa002201.18652413
41Glioma_Homo sapiens_hsa052141.17796411
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17630971
43Calcium signaling pathway_Homo sapiens_hsa040201.15964479
44Type II diabetes mellitus_Homo sapiens_hsa049301.13692145
45Fatty acid metabolism_Homo sapiens_hsa012121.10947800
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07744461
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07204839
48cAMP signaling pathway_Homo sapiens_hsa040241.06291782
49Fat digestion and absorption_Homo sapiens_hsa049751.05509622
50Dorso-ventral axis formation_Homo sapiens_hsa043201.04464096
51Fatty acid biosynthesis_Homo sapiens_hsa000611.03689697
52Estrogen signaling pathway_Homo sapiens_hsa049151.03395723
53mTOR signaling pathway_Homo sapiens_hsa041501.02959743
54Carbon metabolism_Homo sapiens_hsa012001.02476696
55Glucagon signaling pathway_Homo sapiens_hsa049221.02382262
56Vitamin digestion and absorption_Homo sapiens_hsa049771.02055721
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01717573
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.00900940
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99000360
60Butanoate metabolism_Homo sapiens_hsa006500.97836504
61Other glycan degradation_Homo sapiens_hsa005110.97714472
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96266635
63Gap junction_Homo sapiens_hsa045400.95160086
64Dilated cardiomyopathy_Homo sapiens_hsa054140.94476413
65Thyroid hormone synthesis_Homo sapiens_hsa049180.93738091
66Galactose metabolism_Homo sapiens_hsa000520.93716607
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91811919
68VEGF signaling pathway_Homo sapiens_hsa043700.91271176
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90841155
70Base excision repair_Homo sapiens_hsa034100.89140789
71Oocyte meiosis_Homo sapiens_hsa041140.88934403
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.88654671
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.88254743
74DNA replication_Homo sapiens_hsa030300.87130862
75Insulin signaling pathway_Homo sapiens_hsa049100.86841935
76Non-small cell lung cancer_Homo sapiens_hsa052230.86776604
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86079122
78Long-term depression_Homo sapiens_hsa047300.85747873
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85512195
80Tyrosine metabolism_Homo sapiens_hsa003500.84904331
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.84820761
82Insulin resistance_Homo sapiens_hsa049310.84154804
83mRNA surveillance pathway_Homo sapiens_hsa030150.84067908
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.83825797
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83605821
86Prion diseases_Homo sapiens_hsa050200.83590352
87beta-Alanine metabolism_Homo sapiens_hsa004100.81491889
88Cocaine addiction_Homo sapiens_hsa050300.81397966
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78620270
90Biosynthesis of amino acids_Homo sapiens_hsa012300.77329121
91ErbB signaling pathway_Homo sapiens_hsa040120.75980913
92Melanogenesis_Homo sapiens_hsa049160.75877167
93PPAR signaling pathway_Homo sapiens_hsa033200.75242937
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75063897
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74887900
96AMPK signaling pathway_Homo sapiens_hsa041520.74555013
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.73680023
98Cardiac muscle contraction_Homo sapiens_hsa042600.73381543
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69771228
100Endometrial cancer_Homo sapiens_hsa052130.68358251
101Platelet activation_Homo sapiens_hsa046110.68256196
102Pyruvate metabolism_Homo sapiens_hsa006200.68161580
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.64744198
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63393699
105Lysine degradation_Homo sapiens_hsa003100.62463571
106Choline metabolism in cancer_Homo sapiens_hsa052310.61926390
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60124052
108Non-homologous end-joining_Homo sapiens_hsa034500.59511522
109Glutathione metabolism_Homo sapiens_hsa004800.59491996
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58629820
111Taste transduction_Homo sapiens_hsa047420.58050167
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56591755
113Starch and sucrose metabolism_Homo sapiens_hsa005000.56183246
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55943801
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55482973
116Tight junction_Homo sapiens_hsa045300.54978567
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54529234
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51719218
119Inositol phosphate metabolism_Homo sapiens_hsa005620.50706608
120Pancreatic secretion_Homo sapiens_hsa049720.50296125
121One carbon pool by folate_Homo sapiens_hsa006700.48897084
122Spliceosome_Homo sapiens_hsa030400.48862243
123Rap1 signaling pathway_Homo sapiens_hsa040150.47569072
124Cell cycle_Homo sapiens_hsa041100.45490145
125Chronic myeloid leukemia_Homo sapiens_hsa052200.45404988
126N-Glycan biosynthesis_Homo sapiens_hsa005100.44959379
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44709116
128Endocytosis_Homo sapiens_hsa041440.44633851
129Glycerolipid metabolism_Homo sapiens_hsa005610.43055191
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43041085
131Thyroid cancer_Homo sapiens_hsa052160.42205776
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41696890
133Proteoglycans in cancer_Homo sapiens_hsa052050.41544137
134Folate biosynthesis_Homo sapiens_hsa007900.40759468
135Adherens junction_Homo sapiens_hsa045200.39224846
136Vibrio cholerae infection_Homo sapiens_hsa051100.35852487
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.33867595
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.32348984
139Notch signaling pathway_Homo sapiens_hsa043300.31452104

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