MT-CO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.32757271
2ATP synthesis coupled proton transport (GO:0015986)6.74777583
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.74777583
4synaptic vesicle maturation (GO:0016188)6.51088410
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.47171226
6* respiratory electron transport chain (GO:0022904)6.16888457
7* electron transport chain (GO:0022900)6.03738515
8locomotory exploration behavior (GO:0035641)5.95982029
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.68609696
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66047737
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.52411956
12sodium ion export (GO:0071436)5.47106302
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24823757
14cell communication by electrical coupling (GO:0010644)4.90140260
15chaperone-mediated protein transport (GO:0072321)4.87077261
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83205270
17regulation of mitochondrial translation (GO:0070129)4.77438311
18cellular potassium ion homeostasis (GO:0030007)4.68072631
19proteasome assembly (GO:0043248)4.61343448
20regulation of synapse structural plasticity (GO:0051823)4.52579382
21establishment of integrated proviral latency (GO:0075713)4.49901262
22glutamate secretion (GO:0014047)4.49897152
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.44544393
24activation of protein kinase A activity (GO:0034199)4.37366105
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.37272806
26respiratory chain complex IV assembly (GO:0008535)4.28035280
27glycine transport (GO:0015816)4.23378236
28regulation of synaptic vesicle exocytosis (GO:2000300)4.23196608
29potassium ion import (GO:0010107)4.21102671
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.18066234
31ATP biosynthetic process (GO:0006754)4.15800191
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10865883
33neurotransmitter secretion (GO:0007269)4.10587384
34regulation of synaptic vesicle transport (GO:1902803)4.06897099
35proline transport (GO:0015824)4.04436521
36aerobic respiration (GO:0009060)4.03175976
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02728404
38regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02477706
39regulation of neuronal synaptic plasticity (GO:0048168)4.00619761
40membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.00186214
41synaptic vesicle exocytosis (GO:0016079)3.96586332
42membrane repolarization (GO:0086009)3.96381212
43cytochrome complex assembly (GO:0017004)3.95517321
44cell communication involved in cardiac conduction (GO:0086065)3.94660396
45tricarboxylic acid cycle (GO:0006099)3.92225315
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90539767
47regulation of glutamate receptor signaling pathway (GO:1900449)3.89486475
48rRNA modification (GO:0000154)3.84098779
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.83667104
50termination of RNA polymerase III transcription (GO:0006386)3.83667104
51layer formation in cerebral cortex (GO:0021819)3.79160158
52ribosomal small subunit assembly (GO:0000028)3.78927678
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.78870389
54negative regulation of ligase activity (GO:0051352)3.78870389
55DNA replication checkpoint (GO:0000076)3.76818120
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76188509
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72635229
58cellular sodium ion homeostasis (GO:0006883)3.72188155
59* hydrogen ion transmembrane transport (GO:1902600)3.71330389
60neuronal action potential propagation (GO:0019227)3.71279328
61vocalization behavior (GO:0071625)3.70489570
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67847540
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.67594136
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.64902871
65purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63314805
66membrane repolarization during action potential (GO:0086011)3.58479386
67protein complex biogenesis (GO:0070271)3.58220494
68cardiac muscle contraction (GO:0060048)3.55154559
69chromatin remodeling at centromere (GO:0031055)3.54411988
70purine nucleobase biosynthetic process (GO:0009113)3.53425795
71CENP-A containing nucleosome assembly (GO:0034080)3.52082893
72regulation of membrane repolarization (GO:0060306)3.51458042
73exploration behavior (GO:0035640)3.51122113
74mitochondrial respiratory chain complex assembly (GO:0033108)3.46528842
75NADH metabolic process (GO:0006734)3.45609665
76regulation of cellular amino acid metabolic process (GO:0006521)3.42654391
77neuromuscular process controlling balance (GO:0050885)3.42338021
78ribonucleoside triphosphate biosynthetic process (GO:0009201)3.39697613
79regulation of ARF protein signal transduction (GO:0032012)3.35890964
80protein neddylation (GO:0045116)3.35293421
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35203261
82purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.34012957
83purine nucleoside monophosphate biosynthetic process (GO:0009127)3.34012957
84DNA strand elongation involved in DNA replication (GO:0006271)3.31354264
85neuromuscular process controlling posture (GO:0050884)3.31225521
86negative regulation of potassium ion transmembrane transport (GO:1901380)3.30370488
87spliceosomal snRNP assembly (GO:0000387)3.29845820
88gamma-aminobutyric acid transport (GO:0015812)3.29799829
89positive regulation of potassium ion transmembrane transport (GO:1901381)3.29561116
90protein targeting to mitochondrion (GO:0006626)3.28109784
91prepulse inhibition (GO:0060134)3.28018343
92negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26212937
93nucleobase biosynthetic process (GO:0046112)3.26186563
94regulation of oxidative phosphorylation (GO:0002082)3.25774011
95pseudouridine synthesis (GO:0001522)3.25364906
96cardiac conduction (GO:0061337)3.24227895
97positive regulation of membrane potential (GO:0045838)3.23794213
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23561075
99succinate metabolic process (GO:0006105)3.23479358
100potassium ion homeostasis (GO:0055075)3.23421370
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20451530
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20451530
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20451530
104viral transcription (GO:0019083)3.19728523
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19442535
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19442535
107telomere maintenance via semi-conservative replication (GO:0032201)3.19035391
108long-term memory (GO:0007616)3.18522769
109positive regulation of ligase activity (GO:0051351)3.18279331
110negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17682012
111translational termination (GO:0006415)3.17226394
112cotranslational protein targeting to membrane (GO:0006613)3.16250021
113regulation of ubiquitin-protein transferase activity (GO:0051438)3.15299245
114* proton transport (GO:0015992)3.15137208
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15080625
116establishment of viral latency (GO:0019043)3.14168382
117protein targeting to ER (GO:0045047)3.14042347
118signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13724699
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.13724699
120rRNA methylation (GO:0031167)3.13620341
121DNA strand elongation (GO:0022616)3.11656792
122regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.11561960
123ribosomal large subunit biogenesis (GO:0042273)3.11333936
124oxidative phosphorylation (GO:0006119)3.10774642
125* hydrogen transport (GO:0006818)3.09906731
126establishment of protein localization to mitochondrion (GO:0072655)3.09099373
127lysine catabolic process (GO:0006554)3.07812701
128lysine metabolic process (GO:0006553)3.07812701
129mitochondrial respiratory chain complex I assembly (GO:0032981)3.07051794
130NADH dehydrogenase complex assembly (GO:0010257)3.07051794
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07051794
132nucleoside triphosphate biosynthetic process (GO:0009142)3.06188295
133maturation of SSU-rRNA (GO:0030490)3.05459647
134alanine transport (GO:0032328)3.04937757
135G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04898008
136positive regulation of sodium ion transport (GO:0010765)3.04189255
137ribosomal small subunit biogenesis (GO:0042274)3.04178966
138potassium ion export (GO:0071435)3.04018510
139signal transduction involved in cell cycle checkpoint (GO:0072395)3.03512012
140translation (GO:0006412)3.02837828
141cellular respiration (GO:0045333)3.02634488
142regulation of ligase activity (GO:0051340)3.01836090
143neurotransmitter transport (GO:0006836)3.01782231
144establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01122127
145positive regulation of potassium ion transport (GO:0043268)3.00308054
146histone exchange (GO:0043486)2.99132376
147spliceosomal complex assembly (GO:0000245)2.98742056
148regulation of dendritic spine morphogenesis (GO:0061001)2.98255631
149dendritic spine morphogenesis (GO:0060997)2.96875846
150inner mitochondrial membrane organization (GO:0007007)2.96793429
151relaxation of cardiac muscle (GO:0055119)2.95914608
152phosphate ion transport (GO:0006817)2.94581570
153protein localization to mitochondrion (GO:0070585)2.94365312
154kinetochore organization (GO:0051383)2.94363362
155ionotropic glutamate receptor signaling pathway (GO:0035235)2.93688599
156protein localization to endoplasmic reticulum (GO:0070972)2.93404664
157positive regulation of neurotransmitter transport (GO:0051590)2.92888609
158regulation of sodium ion transmembrane transporter activity (GO:2000649)2.92879408
159regulation of heart rate by cardiac conduction (GO:0086091)2.92293275
160translational initiation (GO:0006413)2.91207653
161negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90590863
162ribonucleoside monophosphate biosynthetic process (GO:0009156)2.90476824
163mitochondrial transport (GO:0006839)2.90336130
164regulation of ion transmembrane transporter activity (GO:0032412)2.88537361
165mitotic metaphase plate congression (GO:0007080)2.88236794
166kinetochore assembly (GO:0051382)2.87503887
167nucleoside monophosphate biosynthetic process (GO:0009124)2.86779330
168regulation of clathrin-mediated endocytosis (GO:2000369)2.86655719
169regulation of neurotransmitter levels (GO:0001505)2.86453978
170phosphate ion transmembrane transport (GO:0035435)2.85041634
171pteridine-containing compound biosynthetic process (GO:0042559)2.84662731
172cytoskeletal anchoring at plasma membrane (GO:0007016)2.83530232
173neuronal ion channel clustering (GO:0045161)2.82776154
174exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82358372
175regulation of calcium ion transmembrane transport (GO:1903169)2.82300438
176regulation of calcium ion transmembrane transporter activity (GO:1901019)2.82300438
177carnitine shuttle (GO:0006853)2.81303406
178protein localization to kinetochore (GO:0034501)2.81164507
179positive regulation of neurotransmitter secretion (GO:0001956)2.80930852
180DNA replication-independent nucleosome organization (GO:0034724)2.80166901
181DNA replication-independent nucleosome assembly (GO:0006336)2.80166901
182plasma membrane repair (GO:0001778)2.80145841
183regulation of cellular amine metabolic process (GO:0033238)2.79965680
184regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79924347
185regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79840139
186cAMP biosynthetic process (GO:0006171)2.79201880
187regulation of transmembrane transporter activity (GO:0022898)2.78992234
188nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78062641
189cardiac muscle cell action potential involved in contraction (GO:0086002)2.77724209
190dicarboxylic acid biosynthetic process (GO:0043650)2.77181656
191neurotransmitter-gated ion channel clustering (GO:0072578)2.76421470
192negative regulation of heart contraction (GO:0045822)2.75061175
193regulation of synaptic plasticity (GO:0048167)2.74769115
194positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74468998
195peptidyl-lysine dimethylation (GO:0018027)2.74410479
196synaptic transmission, glutamatergic (GO:0035249)2.74122855
197regulation of sodium ion transmembrane transport (GO:1902305)2.73896455
198membrane depolarization during action potential (GO:0086010)2.73521610
199regulation of sodium ion transport (GO:0002028)2.73355862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13954294
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01861362
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.34719328
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.08933151
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.00957744
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.75256412
7EZH2_22144423_ChIP-Seq_EOC_Human3.51830911
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.48093819
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.44681728
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.41614175
11RARB_27405468_Chip-Seq_BRAIN_Mouse3.36871933
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36039122
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29913589
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.29646326
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29633767
16ETS1_20019798_ChIP-Seq_JURKAT_Human3.11233660
17FOXM1_23109430_ChIP-Seq_U2OS_Human3.02835526
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97232750
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95993133
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91445013
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90796246
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90018478
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.89499748
24DROSHA_22980978_ChIP-Seq_HELA_Human2.81314770
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75537934
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.69931889
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58232841
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54829606
29ZNF263_19887448_ChIP-Seq_K562_Human2.53026916
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47168526
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.43247833
32AR_21909140_ChIP-Seq_LNCAP_Human2.22382750
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19448389
34XRN2_22483619_ChIP-Seq_HELA_Human2.17800719
35ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13591294
36DNAJC2_21179169_ChIP-ChIP_NT2_Human2.10967409
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.08333931
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07315613
39ELK1_19687146_ChIP-ChIP_HELA_Human2.06611357
40TTF2_22483619_ChIP-Seq_HELA_Human2.05701602
41DCP1A_22483619_ChIP-Seq_HELA_Human2.05593628
42FOXP3_21729870_ChIP-Seq_TREG_Human2.00030316
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93267251
44REST_21632747_ChIP-Seq_MESCs_Mouse1.92600423
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91549225
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.91176639
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87770992
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86733695
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.86555185
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.86508147
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84950984
52LXR_22292898_ChIP-Seq_THP-1_Human1.83167200
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82251208
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82084951
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82084951
56KDM2B_26808549_Chip-Seq_K562_Human1.82080818
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81816903
58KDM2B_26808549_Chip-Seq_DND41_Human1.81018163
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80343523
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.79630822
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76181754
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73784476
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73460659
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70406837
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.69793205
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68506338
67VDR_23849224_ChIP-Seq_CD4+_Human1.68449017
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67866036
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67758596
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64688596
71GABP_19822575_ChIP-Seq_HepG2_Human1.62452321
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61810653
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59769405
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59564106
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.58302279
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55408590
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55286037
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53513449
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51510412
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50262715
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48476713
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47712476
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46359488
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46162204
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.45780498
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.44728385
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44702526
88SMC4_20622854_ChIP-Seq_HELA_Human1.43870101
89TCF7_22412390_ChIP-Seq_EML_Mouse1.43132201
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39599781
91P68_20966046_ChIP-Seq_HELA_Human1.39284249
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37500428
93RACK7_27058665_Chip-Seq_MCF-7_Human1.37298196
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.36299908
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35886791
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35573234
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34551332
98MYC_22102868_ChIP-Seq_BL_Human1.34379092
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34187537
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32689566
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32462894
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.31855817
103KDM5A_27292631_Chip-Seq_BREAST_Human1.31596103
104MYC_18940864_ChIP-ChIP_HL60_Human1.31500310
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30005889
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29393518
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.28717092
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.28717092
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28418745
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27818990
111CREB1_26743006_Chip-Seq_LNCaP_Human1.27231720
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25967896
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25611689
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25334679
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25287141
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23036438
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21433128
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21309353
119CTCF_27219007_Chip-Seq_Bcells_Human1.20839238
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19169926
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18369827
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.18356500
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17382840
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.16966122
125OCT4_19829295_ChIP-Seq_ESCs_Human1.15260344
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14495376
127PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13525041
128KLF4_19829295_ChIP-Seq_ESCs_Human1.12413379
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10259045
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.09966824
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09556306
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09195365
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09159214
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08680600
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08062111
136NANOG_16153702_ChIP-ChIP_HESCs_Human1.07217331
137RXR_22108803_ChIP-Seq_LS180_Human1.05546298
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05112192
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05092459
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04722060
141GATA1_19941827_ChIP-Seq_MEL_Mouse1.04596540
142SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03300042
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02140086
144RXR_22158963_ChIP-Seq_LIVER_Mouse1.01819234
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01772198
146TET1_21490601_ChIP-Seq_MESCs_Mouse1.00727308
147EGR1_19374776_ChIP-ChIP_THP-1_Human1.00170974
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.99424583
149GATA1_19941826_ChIP-Seq_K562_Human0.99002140
150E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98891342
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97005030
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96883234
153ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96145129
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.96000256
155BCOR_27268052_Chip-Seq_Bcells_Human0.95837261
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95599349
157TP63_22573176_ChIP-Seq_HFKS_Human0.95289923
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94415435
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94170841
160BCL6_27268052_Chip-Seq_Bcells_Human0.94139286
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.93411427
162UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93325146
163KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92838253
164SA1_27219007_Chip-Seq_Bcells_Human0.92588750
165SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90245597
166FOXA2_19822575_ChIP-Seq_HepG2_Human0.89772025
167ELK1_22589737_ChIP-Seq_MCF10A_Human0.89578207
168SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89188656
169ATF3_27146783_Chip-Seq_COLON_Human0.87310297
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86318736
171E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84017345
172TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83693060
173CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83612391
174PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82931485
175CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82789860
176SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81886170
177KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81191055
178OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79420227
179SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78682054
180CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78438397
181VDR_22108803_ChIP-Seq_LS180_Human0.77921184
182CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77021835
183FOXP1_21924763_ChIP-Seq_HESCs_Human0.76338742
184TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74920467
185TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74808104
186SOX17_20123909_ChIP-Seq_XEN_Mouse0.73982305
187SOX2_16153702_ChIP-ChIP_HESCs_Human0.73568859
188CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72109975
189KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72007342
190KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72007342
191KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72007342
192NANOG_21062744_ChIP-ChIP_HESCs_Human0.71569409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.70207755
2MP0002822_catalepsy4.28682354
3MP0004957_abnormal_blastocyst_morpholog3.65382046
4MP0009379_abnormal_foot_pigmentation3.55513782
5MP0003693_abnormal_embryo_hatching3.54632536
6MP0003635_abnormal_synaptic_transmissio3.21750272
7MP0003111_abnormal_nucleus_morphology3.14695585
8MP0010094_abnormal_chromosome_stability3.14494320
9MP0004043_abnormal_pH_regulation3.09637218
10MP0003941_abnormal_skin_development2.91599943
11MP0008058_abnormal_DNA_repair2.77338252
12MP0000751_myopathy2.74718502
13MP0010234_abnormal_vibrissa_follicle2.58959219
14MP0004084_abnormal_cardiac_muscle2.58242782
15MP0004215_abnormal_myocardial_fiber2.58001241
16MP0009745_abnormal_behavioral_response2.46212469
17MP0003646_muscle_fatigue2.43680395
18MP0008961_abnormal_basal_metabolism2.40737519
19MP0002909_abnormal_adrenal_gland2.32160361
20MP0002063_abnormal_learning/memory/cond2.28978186
21MP0009780_abnormal_chondrocyte_physiolo2.26560834
22MP0003718_maternal_effect2.22663436
23MP0004130_abnormal_muscle_cell2.21259022
24MP0005167_abnormal_blood-brain_barrier2.19622094
25MP0003077_abnormal_cell_cycle2.15616311
26MP0002064_seizures2.05006074
27MP0004270_analgesia2.00411910
28MP0008569_lethality_at_weaning1.99089481
29MP0008932_abnormal_embryonic_tissue1.98021220
30MP0006292_abnormal_olfactory_placode1.94457855
31MP0003806_abnormal_nucleotide_metabolis1.93223735
32MP0003786_premature_aging1.92355511
33MP0009046_muscle_twitch1.91432850
34MP0006036_abnormal_mitochondrial_physio1.85649764
35MP0004484_altered_response_of1.85259608
36MP0008007_abnormal_cellular_replicative1.84754441
37MP0008877_abnormal_DNA_methylation1.84438734
38MP0003787_abnormal_imprinting1.84015887
39MP0003879_abnormal_hair_cell1.83708595
40MP0004885_abnormal_endolymph1.79416426
41MP0004036_abnormal_muscle_relaxation1.77716637
42MP0006035_abnormal_mitochondrial_morpho1.70843075
43MP0008995_early_reproductive_senescence1.70788108
44MP0005330_cardiomyopathy1.68322315
45MP0003283_abnormal_digestive_organ1.68008941
46MP0002938_white_spotting1.65833015
47MP0003186_abnormal_redox_activity1.65603991
48MP0003075_altered_response_to1.58947503
49MP0001501_abnormal_sleep_pattern1.58827906
50MP0002837_dystrophic_cardiac_calcinosis1.56626773
51MP0001486_abnormal_startle_reflex1.56331640
52MP0004019_abnormal_vitamin_homeostasis1.55847701
53MP0002272_abnormal_nervous_system1.55384362
54MP0008775_abnormal_heart_ventricle1.54062888
55MP0004087_abnormal_muscle_fiber1.50835489
56MP0009697_abnormal_copulation1.50327973
57MP0001188_hyperpigmentation1.49795466
58MP0005535_abnormal_body_temperature1.48461734
59MP0004858_abnormal_nervous_system1.47539894
60MP0001968_abnormal_touch/_nociception1.46835992
61MP0005360_urolithiasis1.45177481
62MP0003880_abnormal_central_pattern1.43958978
63MP0000372_irregular_coat_pigmentation1.43390871
64MP0000579_abnormal_nail_morphology1.42943533
65MP0009672_abnormal_birth_weight1.39879169
66MP0008872_abnormal_physiological_respon1.38625465
67MP0002972_abnormal_cardiac_muscle1.37206382
68MP0002572_abnormal_emotion/affect_behav1.37154269
69MP0003136_yellow_coat_color1.37094312
70MP0004510_myositis1.36447273
71MP0006072_abnormal_retinal_apoptosis1.36052397
72MP0000566_synostosis1.35063003
73MP0004147_increased_porphyrin_level1.34720877
74MP0003123_paternal_imprinting1.33877806
75MP0005408_hypopigmentation1.33175389
76MP0002734_abnormal_mechanical_nocicepti1.33130637
77MP0000013_abnormal_adipose_tissue1.31511476
78MP0001529_abnormal_vocalization1.29771091
79MP0000350_abnormal_cell_proliferation1.28973113
80MP0000747_muscle_weakness1.23627304
81MP0005620_abnormal_muscle_contractility1.23444462
82MP0004811_abnormal_neuron_physiology1.22969372
83MP0003300_gastrointestinal_ulcer1.22007781
84MP0001730_embryonic_growth_arrest1.20415612
85MP0003011_delayed_dark_adaptation1.19118382
86MP0001544_abnormal_cardiovascular_syste1.18322652
87MP0005385_cardiovascular_system_phenoty1.18322652
88MP0005423_abnormal_somatic_nervous1.18252490
89MP0003633_abnormal_nervous_system1.18044478
90MP0003137_abnormal_impulse_conducting1.17221472
91MP0004085_abnormal_heartbeat1.16283199
92MP0001697_abnormal_embryo_size1.13601056
93MP0008875_abnormal_xenobiotic_pharmacok1.13157034
94MP0004924_abnormal_behavior1.12172028
95MP0005386_behavior/neurological_phenoty1.12172028
96MP0001765_abnormal_ion_homeostasis1.11537044
97MP0010630_abnormal_cardiac_muscle1.10739265
98MP0003195_calcinosis1.09757299
99MP0005166_decreased_susceptibility_to1.09372703
100MP0003329_amyloid_beta_deposits1.07965524
101MP0002106_abnormal_muscle_physiology1.07557817
102MP0002396_abnormal_hematopoietic_system1.07475368
103MP0005085_abnormal_gallbladder_physiolo1.06667230
104MP0001984_abnormal_olfaction1.04752615
105MP0004145_abnormal_muscle_electrophysio1.04000509
106MP0001346_abnormal_lacrimal_gland1.03309549
107MP0001177_atelectasis1.02453585
108MP0003705_abnormal_hypodermis_morpholog1.02140151
109MP0005636_abnormal_mineral_homeostasis1.01699089
110MP0000749_muscle_degeneration1.01517200
111MP0002089_abnormal_postnatal_growth/wei1.01492296
112MP0003938_abnormal_ear_development1.00844693
113MP0001905_abnormal_dopamine_level1.00107200
114MP0005584_abnormal_enzyme/coenzyme_acti0.99934407
115MP0008057_abnormal_DNA_replication0.98427508
116MP0001970_abnormal_pain_threshold0.98303062
117MP0002733_abnormal_thermal_nociception0.96539668
118MP0005551_abnormal_eye_electrophysiolog0.96237023
119MP0005332_abnormal_amino_acid0.96047705
120MP0001293_anophthalmia0.95550654
121MP0002210_abnormal_sex_determination0.94560891
122MP0002877_abnormal_melanocyte_morpholog0.93729500
123MP0003890_abnormal_embryonic-extraembry0.93674969
124MP0002269_muscular_atrophy0.92180323
125MP0002085_abnormal_embryonic_tissue0.91557750
126MP0006138_congestive_heart_failure0.90769678
127MP0002067_abnormal_sensory_capabilities0.90257763
128MP0005187_abnormal_penis_morphology0.90168040
129MP0001666_abnormal_nutrient_absorption0.87831323
130MP0003567_abnormal_fetal_cardiomyocyte0.87715289
131MP0005666_abnormal_adipose_tissue0.87543615
132MP0002080_prenatal_lethality0.86269754
133MP0000569_abnormal_digit_pigmentation0.86176520
134MP0001881_abnormal_mammary_gland0.86128422
135MP0008874_decreased_physiological_sensi0.86066053
136MP0002139_abnormal_hepatobiliary_system0.85808246
137MP0002066_abnormal_motor_capabilities/c0.85674666
138MP0003121_genomic_imprinting0.85531868
139MP0005646_abnormal_pituitary_gland0.85507204
140MP0001756_abnormal_urination0.85427829
141MP0001485_abnormal_pinna_reflex0.83004386
142MP0001145_abnormal_male_reproductive0.82487797
143MP0003252_abnormal_bile_duct0.82481958
144MP0001672_abnormal_embryogenesis/_devel0.82351608
145MP0005380_embryogenesis_phenotype0.82351608
146MP0001929_abnormal_gametogenesis0.81850242
147MP0002557_abnormal_social/conspecific_i0.81622773
148MP0000631_abnormal_neuroendocrine_gland0.81251932
149MP0002736_abnormal_nociception_after0.81160127
150MP0002796_impaired_skin_barrier0.80893680
151MP0001440_abnormal_grooming_behavior0.80520859
152MP0005670_abnormal_white_adipose0.79520466
153MP0000003_abnormal_adipose_tissue0.79516789
154MP0005369_muscle_phenotype0.79284898
155MP0004233_abnormal_muscle_weight0.77435995
156MP0005375_adipose_tissue_phenotype0.76671095
157MP0002078_abnormal_glucose_homeostasis0.76544313
158MP0002084_abnormal_developmental_patter0.75629617
159MP0003119_abnormal_digestive_system0.74863610
160MP0000653_abnormal_sex_gland0.74734714
161MP0002069_abnormal_eating/drinking_beha0.74664577
162MP0000230_abnormal_systemic_arterial0.73920108
163MP0010329_abnormal_lipoprotein_level0.71678677
164MP0003690_abnormal_glial_cell0.71338224
165MP0003698_abnormal_male_reproductive0.71199255
166MP0000313_abnormal_cell_death0.69424807
167MP0001764_abnormal_homeostasis0.67625266
168MP0002111_abnormal_tail_morphology0.66303525
169MP0003937_abnormal_limbs/digits/tail_de0.65278279
170MP0003984_embryonic_growth_retardation0.64981196
171MP0002090_abnormal_vision0.63970437

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.75656980
2Acute necrotizing encephalopathy (HP:0006965)5.68493338
3Ventricular fibrillation (HP:0001663)5.68146159
4Acute encephalopathy (HP:0006846)5.11364910
5Abnormal mitochondria in muscle tissue (HP:0008316)5.09839654
6Bundle branch block (HP:0011710)5.03922746
7Progressive macrocephaly (HP:0004481)4.82501815
8Mitochondrial inheritance (HP:0001427)4.66337442
9Increased hepatocellular lipid droplets (HP:0006565)4.51464029
10Visual hallucinations (HP:0002367)4.19098408
11Increased CSF lactate (HP:0002490)4.17698043
12Lipid accumulation in hepatocytes (HP:0006561)4.02848861
13Hepatocellular necrosis (HP:0001404)4.02501408
14Focal motor seizures (HP:0011153)3.99123392
15Cerebral edema (HP:0002181)3.73812737
16Hepatic necrosis (HP:0002605)3.69511058
17Papilledema (HP:0001085)3.60631478
18Exercise-induced muscle cramps (HP:0003710)3.55235413
19Heart block (HP:0012722)3.52894988
20Action tremor (HP:0002345)3.52078582
21Exercise-induced myalgia (HP:0003738)3.44603699
22Myoglobinuria (HP:0002913)3.42430287
23Renal Fanconi syndrome (HP:0001994)3.39266383
24Sudden death (HP:0001699)3.29484405
25Abnormal number of erythroid precursors (HP:0012131)3.27991479
26Annular pancreas (HP:0001734)3.20922834
27Abnormality of cells of the erythroid lineage (HP:0012130)3.18539444
28Depression (HP:0000716)3.17077300
29Atrioventricular block (HP:0001678)3.16709783
30Abnormal atrioventricular conduction (HP:0005150)3.15545096
31Macrocytic anemia (HP:0001972)3.15058750
32Poor eye contact (HP:0000817)3.10403050
33Ventricular arrhythmia (HP:0004308)3.09815996
34Abnormal social behavior (HP:0012433)3.09698663
35Impaired social interactions (HP:0000735)3.09698663
36Leukodystrophy (HP:0002415)3.09541348
37Gout (HP:0001997)3.07307319
38Prolonged QT interval (HP:0001657)3.07097315
39Abnormal EKG (HP:0003115)3.02619097
40Hyperinsulinemic hypoglycemia (HP:0000825)2.94772172
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94647083
42Dysmetric saccades (HP:0000641)2.86349502
43Atrial fibrillation (HP:0005110)2.86168637
44Focal seizures (HP:0007359)2.84608570
45Reticulocytopenia (HP:0001896)2.83805881
46Increased intramyocellular lipid droplets (HP:0012240)2.82354357
47Postural instability (HP:0002172)2.82323493
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81110504
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81110504
50Aplastic anemia (HP:0001915)2.80784831
51Hypoglycemic seizures (HP:0002173)2.76201918
52Respiratory failure (HP:0002878)2.75694846
53Primary atrial arrhythmia (HP:0001692)2.75471417
54Syncope (HP:0001279)2.73141911
55Birth length less than 3rd percentile (HP:0003561)2.72345944
56Anxiety (HP:0000739)2.69498540
57Congenital, generalized hypertrichosis (HP:0004540)2.67045548
58Ankle clonus (HP:0011448)2.63965367
59Supraventricular tachycardia (HP:0004755)2.60081548
60Enlarged penis (HP:0000040)2.59784931
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58604764
62Impaired vibration sensation in the lower limbs (HP:0002166)2.58293432
63Lactic acidosis (HP:0003128)2.57654486
64Exercise intolerance (HP:0003546)2.57268435
65Increased circulating renin level (HP:0000848)2.56710290
66Oral leukoplakia (HP:0002745)2.56195317
67Megaloblastic anemia (HP:0001889)2.56097699
68Optic disc pallor (HP:0000543)2.55280139
69Conjunctival hamartoma (HP:0100780)2.54716997
70Sparse eyelashes (HP:0000653)2.52043527
71Increased serum lactate (HP:0002151)2.51753130
72Insomnia (HP:0100785)2.51631775
73Supraventricular arrhythmia (HP:0005115)2.51528994
74Abnormality of the labia minora (HP:0012880)2.49806147
75Cerebral hypomyelination (HP:0006808)2.49077442
76Increased serum pyruvate (HP:0003542)2.48260649
77Resting tremor (HP:0002322)2.47828123
78Abnormality of glycolysis (HP:0004366)2.47184955
79Metabolic alkalosis (HP:0200114)2.46553612
80Torticollis (HP:0000473)2.46194948
81Generalized tonic-clonic seizures (HP:0002069)2.46177871
82Hyperacusis (HP:0010780)2.45996669
83Abnormality of the lower motor neuron (HP:0002366)2.44498644
84Abnormality of homocysteine metabolism (HP:0010919)2.43514330
85Homocystinuria (HP:0002156)2.43514330
86Respiratory difficulties (HP:0002880)2.39783874
87Hypoglycemic coma (HP:0001325)2.39309805
88Hemiplegia (HP:0002301)2.39270895
89Pointed chin (HP:0000307)2.38664806
90Dysdiadochokinesis (HP:0002075)2.38413184
91Exertional dyspnea (HP:0002875)2.37745285
92Palpitations (HP:0001962)2.36159408
93Increased muscle lipid content (HP:0009058)2.35421898
94Focal dystonia (HP:0004373)2.34581415
95Lethargy (HP:0001254)2.31963435
96Ketoacidosis (HP:0001993)2.30933846
97Abnormality of the left ventricular outflow tract (HP:0011103)2.29658646
98Subaortic stenosis (HP:0001682)2.29658646
99Chromsome breakage (HP:0040012)2.27817501
100Hypokalemic alkalosis (HP:0001949)2.27231796
101Hamartoma of the eye (HP:0010568)2.24388000
102Abnormality of methionine metabolism (HP:0010901)2.23094471
103Multiple enchondromatosis (HP:0005701)2.22674905
104Hyperglycinuria (HP:0003108)2.22405430
105Urinary urgency (HP:0000012)2.22021974
106Elfin facies (HP:0004428)2.21726371
107Hyperphosphaturia (HP:0003109)2.20969116
108Pheochromocytoma (HP:0002666)2.20198293
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20062766
110Pancreatic islet-cell hyperplasia (HP:0004510)2.19121728
111Microvesicular hepatic steatosis (HP:0001414)2.16550785
112Meckel diverticulum (HP:0002245)2.15310570
113Methylmalonic acidemia (HP:0002912)2.14084678
114Neoplasm of the peripheral nervous system (HP:0100007)2.13759524
115Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13229462
116Ankyloglossia (HP:0010296)2.12719033
117Craniofacial dystonia (HP:0012179)2.11972432
118Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10373810
119X-linked dominant inheritance (HP:0001423)2.10218749
120Methylmalonic aciduria (HP:0012120)2.09083793
121Symptomatic seizures (HP:0011145)2.06920691
122Lower limb asymmetry (HP:0100559)2.05564948
123Abnormal lung lobation (HP:0002101)2.04949421
124Urinary bladder sphincter dysfunction (HP:0002839)2.04877392
125Macroorchidism (HP:0000053)2.03781907
1263-Methylglutaconic aciduria (HP:0003535)2.03350483
127Absence seizures (HP:0002121)2.02347318
128Tetraplegia (HP:0002445)1.99839691
129Glycosuria (HP:0003076)1.99613606
130Abnormality of urine glucose concentration (HP:0011016)1.99613606
131Intention tremor (HP:0002080)1.99171212
132Status epilepticus (HP:0002133)1.98928212
133Pallor (HP:0000980)1.98770202
134Testicular atrophy (HP:0000029)1.97140402
135Spinal canal stenosis (HP:0003416)1.96685927
136Abnormality of the ileum (HP:0001549)1.96636402
137Abnormality of the preputium (HP:0100587)1.96421808
138Ventricular tachycardia (HP:0004756)1.96002372
139Bradykinesia (HP:0002067)1.95343334
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94267566
141Abnormality of renal resorption (HP:0011038)1.94117831
142Asymmetric septal hypertrophy (HP:0001670)1.93794622
143Abnormality of renin-angiotensin system (HP:0000847)1.92432868
144Nasolacrimal duct obstruction (HP:0000579)1.91771986
145Right ventricular cardiomyopathy (HP:0011663)1.90978025
146Hyperaldosteronism (HP:0000859)1.90178851
147Calf muscle hypertrophy (HP:0008981)1.90045405
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87932807
149Hyperuricemia (HP:0002149)1.87727729
150Increased purine levels (HP:0004368)1.87727729
151Limb hypertonia (HP:0002509)1.87618710
152Abnormality of the vocal cords (HP:0008777)1.87161080
153Abnormality of the anterior horn cell (HP:0006802)1.87081765
154Degeneration of anterior horn cells (HP:0002398)1.87081765
155Hyperammonemia (HP:0001987)1.86704781
156Tinnitus (HP:0000360)1.85630337
157Polygenic inheritance (HP:0010982)1.85628314
158Gaze-evoked nystagmus (HP:0000640)1.84426970
159Progressive cerebellar ataxia (HP:0002073)1.84007342
160Septo-optic dysplasia (HP:0100842)1.83991470
161Abnormality of cochlea (HP:0000375)1.83832253
162Emotional lability (HP:0000712)1.83701843
163Hyperactive renin-angiotensin system (HP:0000841)1.83294300
164Ketosis (HP:0001946)1.82845249
165Neoplasm of the adrenal gland (HP:0100631)1.82662689
166Abnormality of sulfur amino acid metabolism (HP:0004339)1.81485955
167Neuroendocrine neoplasm (HP:0100634)1.80116932
168Abnormality of chloride homeostasis (HP:0011422)1.79975181
169Absent septum pellucidum (HP:0001331)1.79974710
170Myotonia (HP:0002486)1.79622820
171Bilateral microphthalmos (HP:0007633)1.79549735
172Abnormality of placental membranes (HP:0011409)1.78727081
173Amniotic constriction ring (HP:0009775)1.78727081
174Progressive inability to walk (HP:0002505)1.78595912
175Distal upper limb amyotrophy (HP:0007149)1.77658005
176Upper limb amyotrophy (HP:0009129)1.77658005
177Muscle stiffness (HP:0003552)1.77466464
178Neonatal onset (HP:0003623)1.76114131
179Adrenal overactivity (HP:0002717)1.75811095
180CNS demyelination (HP:0007305)1.75695643
181Abnormal eating behavior (HP:0100738)1.75557196
182Abnormal urine phosphate concentration (HP:0012599)1.73558303
183Abnormality of the lacrimal duct (HP:0011481)1.73554513
184Pancytopenia (HP:0001876)1.72274488
185Progressive muscle weakness (HP:0003323)1.71198819
186Delayed CNS myelination (HP:0002188)1.70875231
187Abnormality of the pancreatic islet cells (HP:0006476)1.70801246
188Abnormality of endocrine pancreas physiology (HP:0012093)1.70801246
189Abnormality of chromosome stability (HP:0003220)1.69509773
190Colon cancer (HP:0003003)1.69386357
191Type I transferrin isoform profile (HP:0003642)1.69376515
192Rough bone trabeculation (HP:0100670)1.69098540
193Abnormality of vitamin B metabolism (HP:0004340)1.68895016
194Abnormality of serum amino acid levels (HP:0003112)1.68881812
195Hypomagnesemia (HP:0002917)1.67837147
196Abnormal number of incisors (HP:0011064)1.66439534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.16702544
2BUB14.52942967
3MST43.72097115
4CDC73.70848390
5PRKD33.63168614
6NME13.58713209
7NEK13.58212086
8EIF2AK13.44141771
9TRIB33.42771629
10PBK3.26955032
11LMTK22.97821140
12NTRK32.97436039
13EPHA42.95574021
14PKN22.93981899
15TTK2.90680474
16MAP3K92.90624013
17KSR22.84519193
18CAMKK12.74690039
19DAPK22.71816274
20STK382.50605692
21NME22.45918511
22RIPK12.19673525
23PINK12.15242976
24STK162.14471680
25TNIK2.04742603
26TAOK12.03366998
27PLK32.01529292
28PAK61.98741619
29WEE11.96061035
30SRPK11.89064828
31ALK1.82870247
32MINK11.81819693
33MKNK21.76342248
34PLK41.73091084
35MAP3K21.63002844
36RIPK41.60618452
37TAF11.55260254
38EIF2AK31.54029053
39MKNK11.50519870
40BRSK21.47042153
41MST1R1.43518432
42PDK41.39208270
43PDK31.39208270
44PRKCH1.38267932
45MAP3K131.38040725
46PLK11.37373588
47MAP3K41.30753100
48VRK11.24345017
49BRSK11.23597700
50WNK41.20787751
51MAP2K41.20776233
52MAP3K71.20475062
53NUAK11.20340128
54CAMK11.13553044
55BMPR1B1.09725002
56KSR11.07287184
57CHEK21.06253775
58PDK11.05283035
59DAPK11.03594332
60MAP3K11.03195826
61SGK31.01847386
62TYRO31.01840413
63STK391.01030537
64CDC42BPA1.00770101
65RET0.98803265
66CDK80.96412049
67WNK10.96299759
68CDK50.95325460
69PLK20.94609998
70FGFR20.94101061
71PAK40.93836634
72ATR0.93236009
73FRK0.93154932
74ARAF0.90757942
75PDPK10.88954711
76SIK20.88342685
77EIF2AK20.88334460
78AURKB0.87855746
79STK110.85212570
80NTRK10.84158291
81CAMKK20.83726505
82LATS20.82314161
83CSNK1E0.81347637
84DMPK0.80266795
85PDGFRA0.79646097
86MAP2K60.78901625
87MAP2K70.77970554
88SCYL20.77966351
89TSSK60.77684613
90EPHA20.76012061
91PHKG10.74481359
92PHKG20.74481359
93PNCK0.74253103
94CDK190.73665252
95RAF10.72908792
96TTN0.72391279
97STK240.72376369
98MAPKAPK50.72369001
99BCKDK0.72020414
100BMX0.70503295
101PTK60.70429056
102MAPKAPK30.70295158
103PRKG20.69891810
104CAMK40.69454998
105CSNK2A20.68841043
106CDK70.68114817
107PAK30.67821414
108ILK0.66181606
109CHEK10.64852543
110NTRK20.64558620
111SGK20.64452482
112FES0.62825878
113WNK30.62764812
114CDK30.62570018
115STK40.62342384
116PRKCG0.62272830
117TNK20.61865787
118CSNK2A10.60514561
119GRK10.59720036
120PRKCI0.56588688
121TRIM280.56379880
122DYRK20.55300344
123SGK10.54762252
124SGK4940.54482423
125SGK2230.54482423
126OBSCN0.54329863
127CDK10.53685419
128JAK20.53168776
129ATM0.52682297
130SMG10.52433870
131LRRK20.49840176
132RPS6KA30.47640485
133MAP2K10.45282183
134CDK20.44292068
135MAP2K30.43956559
136MAP3K120.43712653
137RPS6KB20.43197932
138PRKD10.42903979
139PDK20.42827920
140AURKA0.41906494
141PRKDC0.41753829
142PAK10.41492570
143CAMK2D0.41470528
144EEF2K0.41217102
145UHMK10.41160038
146MAP3K80.41097388
147FGFR10.40228302
148MET0.39315573
149DDR20.37735136
150GRK50.37456375
151CSNK1A10.36956444
152TAOK20.35973144
153MAP3K110.35765492
154CDK180.33816139
155PRKAA10.33805096
156STK30.33693707
157PRKACG0.33296524
158PTK2B0.32663476
159ZAK0.32369819
160CLK10.32116900
161OXSR10.31870370
162NEK20.31095569
163CDK140.30994649
164CDK11A0.29906181
165DAPK30.29899013
166CAMK2G0.29807081
167CDK150.29622583
168PRKCZ0.29574065
169MYLK0.28929449
170ERBB20.28713506
171MAPK100.28462896

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.31461682
2Oxidative phosphorylation_Homo sapiens_hsa001904.08996757
3Parkinsons disease_Homo sapiens_hsa050123.54277175
4Ribosome_Homo sapiens_hsa030103.37718305
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.27577553
6Nitrogen metabolism_Homo sapiens_hsa009103.16690034
7DNA replication_Homo sapiens_hsa030302.84205276
8Mismatch repair_Homo sapiens_hsa034302.83191270
9RNA polymerase_Homo sapiens_hsa030202.72088527
10Olfactory transduction_Homo sapiens_hsa047402.67816003
11Huntingtons disease_Homo sapiens_hsa050162.59223032
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.54506660
13Alzheimers disease_Homo sapiens_hsa050102.45263462
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44819305
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42659261
16Protein export_Homo sapiens_hsa030602.40304572
17Synaptic vesicle cycle_Homo sapiens_hsa047212.31602527
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31382507
19Spliceosome_Homo sapiens_hsa030402.30263985
20Homologous recombination_Homo sapiens_hsa034402.30077447
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09307316
22Long-term potentiation_Homo sapiens_hsa047202.06960113
23Circadian entrainment_Homo sapiens_hsa047132.06264133
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01563176
25Gastric acid secretion_Homo sapiens_hsa049711.99170904
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93694881
27One carbon pool by folate_Homo sapiens_hsa006701.91431676
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89115361
29Insulin secretion_Homo sapiens_hsa049111.86463169
30GABAergic synapse_Homo sapiens_hsa047271.73635054
31Amphetamine addiction_Homo sapiens_hsa050311.71333079
32Cardiac muscle contraction_Homo sapiens_hsa042601.67210112
33Salivary secretion_Homo sapiens_hsa049701.63538805
34Morphine addiction_Homo sapiens_hsa050321.62496999
35RNA transport_Homo sapiens_hsa030131.61143642
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60997792
37Base excision repair_Homo sapiens_hsa034101.59847505
38Glutamatergic synapse_Homo sapiens_hsa047241.58908064
39Vitamin B6 metabolism_Homo sapiens_hsa007501.53527853
40Cholinergic synapse_Homo sapiens_hsa047251.53325289
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50104765
42Propanoate metabolism_Homo sapiens_hsa006401.49367484
43Fatty acid degradation_Homo sapiens_hsa000711.48431378
44Dopaminergic synapse_Homo sapiens_hsa047281.42736885
45Folate biosynthesis_Homo sapiens_hsa007901.42523289
46Nicotine addiction_Homo sapiens_hsa050331.41651180
47Nucleotide excision repair_Homo sapiens_hsa034201.36520663
48Bile secretion_Homo sapiens_hsa049761.35249820
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35240772
50Carbon metabolism_Homo sapiens_hsa012001.34149703
51RNA degradation_Homo sapiens_hsa030181.33490565
52Oxytocin signaling pathway_Homo sapiens_hsa049211.32748475
53Pyrimidine metabolism_Homo sapiens_hsa002401.32502199
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32044987
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.30882599
56Type II diabetes mellitus_Homo sapiens_hsa049301.30196000
57Arginine biosynthesis_Homo sapiens_hsa002201.29860742
58GnRH signaling pathway_Homo sapiens_hsa049121.28247961
59Non-homologous end-joining_Homo sapiens_hsa034501.26524696
60Fatty acid elongation_Homo sapiens_hsa000621.22707138
61Calcium signaling pathway_Homo sapiens_hsa040201.18159060
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17805201
63Thyroid hormone synthesis_Homo sapiens_hsa049181.17086447
64Glutathione metabolism_Homo sapiens_hsa004801.16854002
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15404202
66Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14815626
67Cell cycle_Homo sapiens_hsa041101.14457064
68Dilated cardiomyopathy_Homo sapiens_hsa054141.14228842
69cAMP signaling pathway_Homo sapiens_hsa040241.13343870
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12358634
71Purine metabolism_Homo sapiens_hsa002301.10552565
72Basal transcription factors_Homo sapiens_hsa030221.08257696
73Glioma_Homo sapiens_hsa052141.07700701
74Fanconi anemia pathway_Homo sapiens_hsa034601.05543084
75Butanoate metabolism_Homo sapiens_hsa006501.04816283
76Vitamin digestion and absorption_Homo sapiens_hsa049771.04494391
77Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02553301
78Fatty acid metabolism_Homo sapiens_hsa012121.02244227
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99645969
80Cocaine addiction_Homo sapiens_hsa050300.99217095
81Glucagon signaling pathway_Homo sapiens_hsa049220.99209771
82Renin secretion_Homo sapiens_hsa049240.99111472
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.97366915
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94000848
85mRNA surveillance pathway_Homo sapiens_hsa030150.88437395
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88184788
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82704792
88Insulin resistance_Homo sapiens_hsa049310.81265497
89Estrogen signaling pathway_Homo sapiens_hsa049150.80359036
90Non-small cell lung cancer_Homo sapiens_hsa052230.79619530
91Gap junction_Homo sapiens_hsa045400.79472682
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79428997
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78525313
94Biosynthesis of amino acids_Homo sapiens_hsa012300.77869575
95mTOR signaling pathway_Homo sapiens_hsa041500.76996400
96Insulin signaling pathway_Homo sapiens_hsa049100.76482800
97Oocyte meiosis_Homo sapiens_hsa041140.75946811
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75861488
99Selenocompound metabolism_Homo sapiens_hsa004500.75616300
100Metabolic pathways_Homo sapiens_hsa011000.74199328
101Taste transduction_Homo sapiens_hsa047420.74010238
102Long-term depression_Homo sapiens_hsa047300.73308303
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72527139
104Pancreatic secretion_Homo sapiens_hsa049720.72081893
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71576565
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71517989
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70704435
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69024942
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.68525437
110PPAR signaling pathway_Homo sapiens_hsa033200.67840569
111Dorso-ventral axis formation_Homo sapiens_hsa043200.67678162
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66743971
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66074613
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.64892470
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.64296984
116Arginine and proline metabolism_Homo sapiens_hsa003300.63555366
117VEGF signaling pathway_Homo sapiens_hsa043700.62661037
118Melanogenesis_Homo sapiens_hsa049160.62435008
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61798241
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.61745437
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61600943
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61273077
123Collecting duct acid secretion_Homo sapiens_hsa049660.60492197
124Pyruvate metabolism_Homo sapiens_hsa006200.60387522
125Chemical carcinogenesis_Homo sapiens_hsa052040.59200581
126Fat digestion and absorption_Homo sapiens_hsa049750.59189603
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.58898502
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58394292
129beta-Alanine metabolism_Homo sapiens_hsa004100.58330405
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57223515
131Retinol metabolism_Homo sapiens_hsa008300.56706160
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56436388
133Tyrosine metabolism_Homo sapiens_hsa003500.56350814
134Endometrial cancer_Homo sapiens_hsa052130.55175104
135HIF-1 signaling pathway_Homo sapiens_hsa040660.54116258
136Steroid biosynthesis_Homo sapiens_hsa001000.52276410
137Phenylalanine metabolism_Homo sapiens_hsa003600.51375048
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.49435453
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48761243
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48458838
141Tryptophan metabolism_Homo sapiens_hsa003800.46553985
142Choline metabolism in cancer_Homo sapiens_hsa052310.45837623
143Starch and sucrose metabolism_Homo sapiens_hsa005000.45650094
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45075437
145Fructose and mannose metabolism_Homo sapiens_hsa000510.44841526
146Type I diabetes mellitus_Homo sapiens_hsa049400.44495609
147Lysine degradation_Homo sapiens_hsa003100.44376171
148Glycerolipid metabolism_Homo sapiens_hsa005610.44043826
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.43937505
150Inositol phosphate metabolism_Homo sapiens_hsa005620.43833926
151ErbB signaling pathway_Homo sapiens_hsa040120.43793406
152Phototransduction_Homo sapiens_hsa047440.43213920
153Mineral absorption_Homo sapiens_hsa049780.42937501
154Thyroid cancer_Homo sapiens_hsa052160.41329629
155AMPK signaling pathway_Homo sapiens_hsa041520.41168731
156Galactose metabolism_Homo sapiens_hsa000520.40270812
157Pentose phosphate pathway_Homo sapiens_hsa000300.38927532
158Peroxisome_Homo sapiens_hsa041460.38798150
159Sulfur metabolism_Homo sapiens_hsa009200.38159718
160N-Glycan biosynthesis_Homo sapiens_hsa005100.37917949
161Platelet activation_Homo sapiens_hsa046110.37198456
162Caffeine metabolism_Homo sapiens_hsa002320.37139466
163Sulfur relay system_Homo sapiens_hsa041220.31674923
164Histidine metabolism_Homo sapiens_hsa003400.29582582
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27662809
166Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24660213
167Wnt signaling pathway_Homo sapiens_hsa043100.22485995
168Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18084473

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