MT-CO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.78521824
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.67967941
3locomotory exploration behavior (GO:0035641)5.15490432
4oxidative phosphorylation (GO:0006119)5.14320772
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76820409
6ribosomal small subunit biogenesis (GO:0042274)4.57430569
7tricarboxylic acid cycle (GO:0006099)4.56041970
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.39314244
9ribosomal small subunit assembly (GO:0000028)4.36061433
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.19475409
11viral transcription (GO:0019083)4.12248165
12membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.10152543
13regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.08205152
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05592416
15regulation of synapse structural plasticity (GO:0051823)4.02992146
16cell communication by electrical coupling (GO:0010644)3.91089009
17translational termination (GO:0006415)3.85076389
18regulation of synaptic vesicle transport (GO:1902803)3.83244716
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.81179701
20NADH metabolic process (GO:0006734)3.80988855
21glutamate secretion (GO:0014047)3.78540077
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76852288
23regulation of synaptic vesicle exocytosis (GO:2000300)3.74399313
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72845157
25membrane repolarization during action potential (GO:0086011)3.71094464
26ATP biosynthetic process (GO:0006754)3.70441261
27succinate metabolic process (GO:0006105)3.68810693
28neurotransmitter secretion (GO:0007269)3.66593653
29membrane repolarization (GO:0086009)3.62862458
30regulation of neuronal synaptic plasticity (GO:0048168)3.59205577
31potassium ion homeostasis (GO:0055075)3.52734667
32potassium ion export (GO:0071435)3.52016978
33proline biosynthetic process (GO:0006561)3.49122634
34cardiac conduction (GO:0061337)3.48707547
35cardiac muscle contraction (GO:0060048)3.47809560
36regulation of mitochondrial translation (GO:0070129)3.41654562
37synaptic vesicle exocytosis (GO:0016079)3.40989214
38activation of protein kinase A activity (GO:0034199)3.40383638
39regulation of glutamate receptor signaling pathway (GO:1900449)3.40022272
40regulation of membrane repolarization (GO:0060306)3.36730127
41oxaloacetate metabolic process (GO:0006107)3.35110145
42chaperone-mediated protein transport (GO:0072321)3.35106616
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32076393
44potassium ion import (GO:0010107)3.30543471
45translational elongation (GO:0006414)3.29419477
46protein targeting to ER (GO:0045047)3.28899440
47cotranslational protein targeting to membrane (GO:0006613)3.28300841
48sodium ion export (GO:0071436)3.25816937
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.25027207
50establishment of integrated proviral latency (GO:0075713)3.24958879
51positive regulation of respiratory burst (GO:0060267)3.22333202
52cellular protein complex disassembly (GO:0043624)3.22114298
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21616131
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19561382
55neuronal action potential propagation (GO:0019227)3.18815154
56positive regulation of synapse maturation (GO:0090129)3.16715811
57* respiratory electron transport chain (GO:0022904)3.15601311
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15358148
59regulation of heart rate by cardiac conduction (GO:0086091)3.14089543
60protein localization to endoplasmic reticulum (GO:0070972)3.14024184
61glycine transport (GO:0015816)3.12513175
62purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.11128563
63purine nucleoside monophosphate biosynthetic process (GO:0009127)3.11128563
64positive regulation of neurotransmitter secretion (GO:0001956)3.09124006
65positive regulation of neurotransmitter transport (GO:0051590)3.09077599
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09027069
67cellular potassium ion homeostasis (GO:0030007)3.08442905
68proline transport (GO:0015824)3.08121195
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07712769
70* electron transport chain (GO:0022900)3.07647976
71positive regulation of potassium ion transmembrane transport (GO:1901381)3.06362407
72inositol phosphate catabolic process (GO:0071545)3.05878429
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05011122
74prepulse inhibition (GO:0060134)3.04793917
75regulation of translational fidelity (GO:0006450)3.04294936
76DNA unwinding involved in DNA replication (GO:0006268)3.02679655
77ribonucleoside triphosphate biosynthetic process (GO:0009201)3.02075323
78purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01939298
79viral life cycle (GO:0019058)3.01740986
80positive regulation of membrane potential (GO:0045838)2.98205234
81meiotic chromosome segregation (GO:0045132)2.97977409
82necroptotic process (GO:0070266)2.97890519
83translational initiation (GO:0006413)2.96461711
84relaxation of cardiac muscle (GO:0055119)2.96241537
85kinetochore organization (GO:0051383)2.95538099
86cell communication involved in cardiac conduction (GO:0086065)2.94974256
87adenine nucleotide transport (GO:0051503)2.94588757
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94540476
89protein complex disassembly (GO:0043241)2.90806583
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88789697
91negative regulation of RNA splicing (GO:0033119)2.88580978
92chromatin remodeling at centromere (GO:0031055)2.87972551
93regulation of relaxation of muscle (GO:1901077)2.86476507
94exploration behavior (GO:0035640)2.85653768
95ribosomal large subunit biogenesis (GO:0042273)2.85139043
96nucleoside monophosphate biosynthetic process (GO:0009124)2.84280808
97* aerobic respiration (GO:0009060)2.84053496
98regulation of oxidative phosphorylation (GO:0002082)2.82795236
99DNA strand elongation involved in DNA replication (GO:0006271)2.82327466
100regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.80693543
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80247614
102proline metabolic process (GO:0006560)2.79948836
103long-term memory (GO:0007616)2.79168722
104negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79018796
105positive regulation of potassium ion transport (GO:0043268)2.78308856
106maturation of SSU-rRNA (GO:0030490)2.78282499
107ribonucleoside monophosphate biosynthetic process (GO:0009156)2.77111399
108IMP biosynthetic process (GO:0006188)2.76316686
109CENP-A containing nucleosome assembly (GO:0034080)2.75255589
110negative regulation of mRNA processing (GO:0050686)2.74869740
111synaptic transmission, glutamatergic (GO:0035249)2.73543389
112purine nucleobase biosynthetic process (GO:0009113)2.73324970
113nucleoside triphosphate biosynthetic process (GO:0009142)2.72968242
114aminoglycoside antibiotic metabolic process (GO:0030647)2.71737380
115cardiac muscle cell action potential involved in contraction (GO:0086002)2.71261441
116RNA-dependent DNA replication (GO:0006278)2.71118077
117vocalization behavior (GO:0071625)2.70604560
118creatine metabolic process (GO:0006600)2.70049483
119macromolecular complex disassembly (GO:0032984)2.68400447
120heterochromatin organization (GO:0070828)2.67596942
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67462774
122nucleobase-containing small molecule interconversion (GO:0015949)2.67217121
123heart process (GO:0003015)2.67194559
124heart contraction (GO:0060047)2.67194559
125neurotransmitter-gated ion channel clustering (GO:0072578)2.67020714
126energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66758054
127ATP synthesis coupled proton transport (GO:0015986)2.66758054
128nucleoside diphosphate biosynthetic process (GO:0009133)2.66060642
129DNA strand elongation (GO:0022616)2.65325143
130neurotransmitter transport (GO:0006836)2.62891672
131* hydrogen ion transmembrane transport (GO:1902600)2.62022834
132cerebellar granule cell differentiation (GO:0021707)2.60614988
133regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.60228796
134purine nucleotide transport (GO:0015865)2.60134394
135striated muscle contraction (GO:0006941)2.59960551
136mitotic chromosome condensation (GO:0007076)2.59778432
137striatum development (GO:0021756)2.59091625
138L-amino acid import (GO:0043092)2.58160668
139pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57701311
140negative regulation of dendrite morphogenesis (GO:0050774)2.56631322
141nucleobase biosynthetic process (GO:0046112)2.56610334
142cAMP biosynthetic process (GO:0006171)2.55817263
143cellular sodium ion homeostasis (GO:0006883)2.55672008
144regulation of cellular respiration (GO:0043457)2.55067477
145telomere maintenance via telomerase (GO:0007004)2.54373319
146response to ischemia (GO:0002931)2.53766795
147negative regulation of heart contraction (GO:0045822)2.53547374
148ribonucleoprotein complex biogenesis (GO:0022613)2.53294480
149regulation of mitotic spindle organization (GO:0060236)2.53168235
150vitamin transmembrane transport (GO:0035461)2.52588505
151telomere maintenance via semi-conservative replication (GO:0032201)2.52463304
152polyketide metabolic process (GO:0030638)2.52443704
153doxorubicin metabolic process (GO:0044598)2.52443704
154daunorubicin metabolic process (GO:0044597)2.52443704
155megakaryocyte development (GO:0035855)2.52436343
156necrotic cell death (GO:0070265)2.52306919
1572-deoxyribonucleotide biosynthetic process (GO:0009265)2.52267816
158deoxyribose phosphate biosynthetic process (GO:0046385)2.52267816
159regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.51461036
160formation of translation preinitiation complex (GO:0001731)2.48852310
161protein complex localization (GO:0031503)2.46025864
162cerebellar Purkinje cell layer development (GO:0021680)2.45267154
163translation (GO:0006412)2.43082811
164positive regulation of cellular amine metabolic process (GO:0033240)2.42695586
165negative regulation of telomerase activity (GO:0051974)2.41930926
166regulation of dopamine metabolic process (GO:0042053)2.39087678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.63729065
2EZH2_22144423_ChIP-Seq_EOC_Human3.94885265
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.92362550
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.52434315
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.34624333
6GATA1_22025678_ChIP-Seq_K562_Human3.27413482
7RARB_27405468_Chip-Seq_BRAIN_Mouse3.04442949
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91744264
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74820199
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67412573
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.49869083
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43991096
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41857328
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40392787
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38307626
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29859175
17ZNF263_19887448_ChIP-Seq_K562_Human2.29541085
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24031102
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16323782
20DROSHA_22980978_ChIP-Seq_HELA_Human2.15086472
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.09191773
22XRN2_22483619_ChIP-Seq_HELA_Human2.08980378
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08641352
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99647575
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95426863
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.94071489
27LXR_22292898_ChIP-Seq_THP-1_Human1.92219195
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91148399
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89497532
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.88136846
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88087737
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86509844
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78867743
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.78466784
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74740504
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70239160
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69446535
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66318069
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.65882811
40REST_21632747_ChIP-Seq_MESCs_Mouse1.64714283
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63870916
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59705137
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58627498
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57883878
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57685548
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.54477253
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.53204813
48MYC_22102868_ChIP-Seq_BL_Human1.52540572
49RACK7_27058665_Chip-Seq_MCF-7_Human1.52339253
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51439008
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.49826517
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47907117
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47483244
54P68_20966046_ChIP-Seq_HELA_Human1.46386444
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41633047
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38830390
57OCT4_18692474_ChIP-Seq_MEFs_Mouse1.38332556
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.38108209
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37391672
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37098806
61TTF2_22483619_ChIP-Seq_HELA_Human1.37023511
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36726065
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34279106
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31927227
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.31538890
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31257353
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30682727
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29670640
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28949416
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27893759
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24727994
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24635518
73SCL_19346495_ChIP-Seq_HPC-7_Human1.24433672
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24328717
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24294333
76CTCF_27219007_Chip-Seq_Bcells_Human1.23056525
77CREB1_26743006_Chip-Seq_LNCaP_Human1.22933708
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22146842
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21733593
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19417298
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.19390916
82CIITA_25753668_ChIP-Seq_RAJI_Human1.18825085
83GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18351682
84DCP1A_22483619_ChIP-Seq_HELA_Human1.18021854
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17916827
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17431140
87SA1_27219007_Chip-Seq_Bcells_Human1.16363399
88SMC4_20622854_ChIP-Seq_HELA_Human1.16219252
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15874142
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14837655
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14778119
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13816897
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10443623
94FOXP1_21924763_ChIP-Seq_HESCs_Human1.10230077
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.07940430
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06728967
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06574874
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06574874
99CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05917354
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05775178
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05233306
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04869658
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04559919
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04347530
105SALL4_22934838_ChIP-ChIP_CD34+_Human1.04115361
106VDR_21846776_ChIP-Seq_THP-1_Human1.03727236
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03280816
108SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02966245
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01773239
110KDM2B_26808549_Chip-Seq_K562_Human1.01353220
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00564331
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00270291
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99662134
114RAC3_21632823_ChIP-Seq_H3396_Human0.99321649
115KAP1_27257070_Chip-Seq_ESCs_Mouse0.98887832
116MYC_18555785_ChIP-Seq_MESCs_Mouse0.98755010
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98708045
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98472170
119TP53_22573176_ChIP-Seq_HFKS_Human0.98192971
120TCF4_22108803_ChIP-Seq_LS180_Human0.97796219
121KDM5A_27292631_Chip-Seq_BREAST_Human0.97441453
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97419648
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.97312680
124MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96943220
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95318337
126TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94780535
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94543425
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94475394
129HOXB7_26014856_ChIP-Seq_BT474_Human0.93298378
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93112659
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92931419
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92470800
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92073138
134TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91845652
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91820675
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91607754
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88601312
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86704169
139SMAD4_21799915_ChIP-Seq_A2780_Human0.86348144
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85358951
141BCL6_27268052_Chip-Seq_Bcells_Human0.84535669
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84136007
143AR_21909140_ChIP-Seq_LNCAP_Human0.83280687
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82691781
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82524652
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82367992
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81197384
148TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80060835
149GBX2_23144817_ChIP-Seq_PC3_Human0.79910304
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79761980
151RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79091197
152ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79062362
153LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78648010
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77042660
155SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76566072
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76293186
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76237473
158GATA3_26560356_Chip-Seq_TH1_Human0.75356846
159TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74686324
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.74050884
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73813665
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72527906
163EP300_21415370_ChIP-Seq_HL-1_Mouse0.70764636
164GATA1_19941827_ChIP-Seq_MEL_Mouse0.70543662
165TCF4_23295773_ChIP-Seq_U87_Human0.70344605
166WDR5_24793694_ChIP-Seq_LNCAP_Human0.69819770
167TAF2_19829295_ChIP-Seq_ESCs_Human0.69756107
168AR_19668381_ChIP-Seq_PC3_Human0.69248614
169IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69015398
170E2F1_17053090_ChIP-ChIP_MCF-7_Human0.68732640
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.68474796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.82319570
2MP0003787_abnormal_imprinting4.30877788
3MP0009379_abnormal_foot_pigmentation4.07497934
4MP0002822_catalepsy3.86831665
5MP0003123_paternal_imprinting3.09237888
6MP0004043_abnormal_pH_regulation2.92419015
7MP0008877_abnormal_DNA_methylation2.91635448
8MP0003635_abnormal_synaptic_transmissio2.68411463
9MP0003693_abnormal_embryo_hatching2.62125033
10MP0004215_abnormal_myocardial_fiber2.47062071
11MP0006036_abnormal_mitochondrial_physio2.40039574
12MP0004957_abnormal_blastocyst_morpholog2.34627564
13MP0003111_abnormal_nucleus_morphology2.30819085
14MP0009745_abnormal_behavioral_response2.29871216
15MP0005646_abnormal_pituitary_gland2.14351212
16MP0001177_atelectasis2.03669127
17MP0002063_abnormal_learning/memory/cond2.02405045
18MP0004147_increased_porphyrin_level1.99106049
19MP0000566_synostosis1.98275506
20MP0004084_abnormal_cardiac_muscle1.92419270
21MP0008995_early_reproductive_senescence1.91328580
22MP0000751_myopathy1.90607763
23MP0001188_hyperpigmentation1.85471157
24MP0009672_abnormal_birth_weight1.83656868
25MP0008569_lethality_at_weaning1.77942516
26MP0003941_abnormal_skin_development1.74235918
27MP0009697_abnormal_copulation1.67939473
28MP0008872_abnormal_physiological_respon1.66472853
29MP0000569_abnormal_digit_pigmentation1.62453854
30MP0003879_abnormal_hair_cell1.61799823
31MP0005670_abnormal_white_adipose1.59272571
32MP0004484_altered_response_of1.57245236
33MP0002796_impaired_skin_barrier1.53607201
34MP0004019_abnormal_vitamin_homeostasis1.51960736
35MP0002249_abnormal_larynx_morphology1.51831322
36MP0002272_abnormal_nervous_system1.49843799
37MP0008961_abnormal_basal_metabolism1.49692534
38MP0002396_abnormal_hematopoietic_system1.49617219
39MP0002876_abnormal_thyroid_physiology1.48634629
40MP0003121_genomic_imprinting1.45055637
41MP0010234_abnormal_vibrissa_follicle1.44677459
42MP0009780_abnormal_chondrocyte_physiolo1.40822661
43MP0002909_abnormal_adrenal_gland1.40292221
44MP0002064_seizures1.39817120
45MP0001486_abnormal_startle_reflex1.39457274
46MP0009046_muscle_twitch1.39169681
47MP0001968_abnormal_touch/_nociception1.34156044
48MP0004036_abnormal_muscle_relaxation1.32668246
49MP0005167_abnormal_blood-brain_barrier1.32058255
50MP0003943_abnormal_hepatobiliary_system1.31356891
51MP0005360_urolithiasis1.31084828
52MP0010094_abnormal_chromosome_stability1.29689826
53MP0008932_abnormal_embryonic_tissue1.29562246
54MP0001730_embryonic_growth_arrest1.29216388
55MP0003646_muscle_fatigue1.29090729
56MP0001501_abnormal_sleep_pattern1.22049041
57MP0005666_abnormal_adipose_tissue1.21748680
58MP0001346_abnormal_lacrimal_gland1.21177070
59MP0004808_abnormal_hematopoietic_stem1.19851423
60MP0002139_abnormal_hepatobiliary_system1.18644215
61MP0000350_abnormal_cell_proliferation1.18411470
62MP0003077_abnormal_cell_cycle1.18236996
63MP0006054_spinal_hemorrhage1.16020343
64MP0008775_abnormal_heart_ventricle1.15646306
65MP0004185_abnormal_adipocyte_glucose1.15265052
66MP0002733_abnormal_thermal_nociception1.14737184
67MP0005535_abnormal_body_temperature1.13880904
68MP0000579_abnormal_nail_morphology1.13363433
69MP0004885_abnormal_endolymph1.12721694
70MP0002572_abnormal_emotion/affect_behav1.11632022
71MP0002160_abnormal_reproductive_system1.10747424
72MP0001485_abnormal_pinna_reflex1.10320979
73MP0002972_abnormal_cardiac_muscle1.08134332
74MP0003718_maternal_effect1.06700604
75MP0005386_behavior/neurological_phenoty1.06271020
76MP0004924_abnormal_behavior1.06271020
77MP0002734_abnormal_mechanical_nocicepti1.05417992
78MP0001666_abnormal_nutrient_absorption1.03162561
79MP0003075_altered_response_to1.03070328
80MP0001970_abnormal_pain_threshold1.02577812
81MP0005636_abnormal_mineral_homeostasis1.02420992
82MP0000678_abnormal_parathyroid_gland1.02211201
83MP0001984_abnormal_olfaction1.02135355
84MP0005330_cardiomyopathy1.01042525
85MP0004264_abnormal_extraembryonic_tissu1.00684250
86MP0005423_abnormal_somatic_nervous1.00042928
87MP0002736_abnormal_nociception_after0.99495950
88MP0003283_abnormal_digestive_organ0.98666146
89MP0004811_abnormal_neuron_physiology0.96061897
90MP0001502_abnormal_circadian_rhythm0.95939815
91MP0001881_abnormal_mammary_gland0.95744213
92MP0001545_abnormal_hematopoietic_system0.95491628
93MP0005397_hematopoietic_system_phenotyp0.95491628
94MP0005620_abnormal_muscle_contractility0.95217606
95MP0004858_abnormal_nervous_system0.93694254
96MP0003137_abnormal_impulse_conducting0.93072632
97MP0005385_cardiovascular_system_phenoty0.92967114
98MP0001544_abnormal_cardiovascular_syste0.92967114
99MP0003329_amyloid_beta_deposits0.91603145
100MP0004130_abnormal_muscle_cell0.91403289
101MP0003880_abnormal_central_pattern0.91260397
102MP0010386_abnormal_urinary_bladder0.90926552
103MP0004510_myositis0.89691469
104MP0002066_abnormal_motor_capabilities/c0.89079372
105MP0004270_analgesia0.88934993
106MP0002557_abnormal_social/conspecific_i0.88594876
107MP0005584_abnormal_enzyme/coenzyme_acti0.87074711
108MP0003786_premature_aging0.86616404
109MP0005085_abnormal_gallbladder_physiolo0.86081621
110MP0002089_abnormal_postnatal_growth/wei0.85292918
111MP0005332_abnormal_amino_acid0.85052698
112MP0003938_abnormal_ear_development0.84679639
113MP0008058_abnormal_DNA_repair0.83995398
114MP0002638_abnormal_pupillary_reflex0.83042392
115MP0003633_abnormal_nervous_system0.82516085
116MP0001765_abnormal_ion_homeostasis0.82339663
117MP0005409_darkened_coat_color0.81525894
118MP0000462_abnormal_digestive_system0.81259857
119MP0005501_abnormal_skin_physiology0.81221723
120MP0002210_abnormal_sex_determination0.79495474
121MP0005166_decreased_susceptibility_to0.78862185
122MP0004087_abnormal_muscle_fiber0.78390223
123MP0001119_abnormal_female_reproductive0.78139092
124MP0005645_abnormal_hypothalamus_physiol0.75981381
125MP0003195_calcinosis0.75483737
126MP0001905_abnormal_dopamine_level0.74854646
127MP0002067_abnormal_sensory_capabilities0.74801811
128MP0010630_abnormal_cardiac_muscle0.74749922
129MP0004085_abnormal_heartbeat0.74546176
130MP0008004_abnormal_stomach_pH0.74177359
131MP0002928_abnormal_bile_duct0.73556687
132MP0001731_abnormal_postnatal_growth0.73365409
133MP0001664_abnormal_digestion0.73097770
134MP0002080_prenatal_lethality0.72932097
135MP0006035_abnormal_mitochondrial_morpho0.72866503
136MP0002106_abnormal_muscle_physiology0.72055750
137MP0008007_abnormal_cellular_replicative0.71212030
138MP0003567_abnormal_fetal_cardiomyocyte0.70781308
139MP0002069_abnormal_eating/drinking_beha0.69935444
140MP0000749_muscle_degeneration0.69508085
141MP0001764_abnormal_homeostasis0.69125434
142MP0005389_reproductive_system_phenotype0.68730635
143MP0002873_normal_phenotype0.68403175
144MP0002877_abnormal_melanocyte_morpholog0.68367068
145MP0000230_abnormal_systemic_arterial0.68206055
146MP0002735_abnormal_chemical_nociception0.67888766
147MP0002169_no_abnormal_phenotype0.67659856
148MP0001697_abnormal_embryo_size0.67177031
149MP0001440_abnormal_grooming_behavior0.66354925
150MP0004782_abnormal_surfactant_physiolog0.63769613
151MP0003186_abnormal_redox_activity0.62150785
152MP0005380_embryogenesis_phenotype0.62144755
153MP0001672_abnormal_embryogenesis/_devel0.62144755
154MP0000313_abnormal_cell_death0.61880938
155MP0003956_abnormal_body_size0.60311118
156MP0000477_abnormal_intestine_morphology0.60112177

Predicted human phenotypes

RankGene SetZ-score
1Ventricular fibrillation (HP:0001663)5.37571061
2Myokymia (HP:0002411)4.93875209
3Bundle branch block (HP:0011710)3.86294145
4Visual hallucinations (HP:0002367)3.57766803
5Focal motor seizures (HP:0011153)3.54315767
6Cerebral hypomyelination (HP:0006808)3.42233847
7Macrocytic anemia (HP:0001972)3.41546857
8Papilledema (HP:0001085)3.39778159
9Exercise-induced muscle cramps (HP:0003710)3.37298436
10Conjunctival hamartoma (HP:0100780)3.27029178
11Neoplasm of the adrenal gland (HP:0100631)3.23034425
12Abnormal EKG (HP:0003115)3.18787090
13Acute necrotizing encephalopathy (HP:0006965)3.11754672
14Exercise-induced myalgia (HP:0003738)3.05908234
15Aplastic anemia (HP:0001915)3.04459394
16Palpitations (HP:0001962)3.03111552
17Acute encephalopathy (HP:0006846)2.99658046
18Annular pancreas (HP:0001734)2.96235581
19Truncus arteriosus (HP:0001660)2.95087687
20Hypoglycemic seizures (HP:0002173)2.93601186
21Abnormality of cells of the erythroid lineage (HP:0012130)2.93207010
22Poor eye contact (HP:0000817)2.90028413
23Renal cortical cysts (HP:0000803)2.81411553
24Action tremor (HP:0002345)2.80293650
25Atrial fibrillation (HP:0005110)2.77491598
26Prolonged QT interval (HP:0001657)2.73348984
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71802248
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71802248
29Abnormal number of erythroid precursors (HP:0012131)2.71704952
30Myoglobinuria (HP:0002913)2.71362487
31Hyperthyroidism (HP:0000836)2.71301340
32Enlarged penis (HP:0000040)2.69718618
33Abnormality of glycolysis (HP:0004366)2.67071883
34Anxiety (HP:0000739)2.66632830
35Ventricular arrhythmia (HP:0004308)2.66134250
36Primary atrial arrhythmia (HP:0001692)2.56795151
37Obstructive sleep apnea (HP:0002870)2.53717327
38Megaloblastic anemia (HP:0001889)2.53171466
39Epileptic encephalopathy (HP:0200134)2.52274037
40Generalized aminoaciduria (HP:0002909)2.51974986
41Colon cancer (HP:0003003)2.51794397
42Progressive muscle weakness (HP:0003323)2.50335588
43Supraventricular tachycardia (HP:0004755)2.50278622
44Febrile seizures (HP:0002373)2.49512840
45Asymmetry of the thorax (HP:0001555)2.47550801
46Ankle clonus (HP:0011448)2.47148041
47Mitochondrial inheritance (HP:0001427)2.47036971
48Heart block (HP:0012722)2.47035685
49Reticulocytopenia (HP:0001896)2.46955362
50Tetraplegia (HP:0002445)2.45441377
51Depression (HP:0000716)2.44461543
52Increased serum pyruvate (HP:0003542)2.44191155
53Cerebral edema (HP:0002181)2.43460412
54Meningioma (HP:0002858)2.42541281
55Increased intramyocellular lipid droplets (HP:0012240)2.40570513
56Hepatic necrosis (HP:0002605)2.40206363
57Hyperinsulinemic hypoglycemia (HP:0000825)2.39141800
58Pheochromocytoma (HP:0002666)2.38207640
59Supraventricular arrhythmia (HP:0005115)2.38061452
60Limb hypertonia (HP:0002509)2.36786707
61Dysphonia (HP:0001618)2.33838727
62Tinnitus (HP:0000360)2.33335908
63Azoospermia (HP:0000027)2.32383918
64Microvesicular hepatic steatosis (HP:0001414)2.31659541
65Proximal tubulopathy (HP:0000114)2.30670391
66Impaired vibration sensation in the lower limbs (HP:0002166)2.29589862
67Impaired social interactions (HP:0000735)2.29302532
68Abnormal social behavior (HP:0012433)2.29302532
69Multiple enchondromatosis (HP:0005701)2.28681642
70Thrombocytosis (HP:0001894)2.24690809
71Leukodystrophy (HP:0002415)2.24479495
72Hypokalemic alkalosis (HP:0001949)2.22977445
73Spinal canal stenosis (HP:0003416)2.21876594
74Abnormality of cochlea (HP:0000375)2.20338422
75Abnormality of the left ventricular outflow tract (HP:0011103)2.19497792
76Subaortic stenosis (HP:0001682)2.19497792
77Hyperglycinuria (HP:0003108)2.18966599
78Neonatal hypoglycemia (HP:0001998)2.14471464
79Gout (HP:0001997)2.11480903
80Abnormal atrioventricular conduction (HP:0005150)2.10211277
81Hyperaldosteronism (HP:0000859)2.09933678
82Hyperactive renin-angiotensin system (HP:0000841)2.09344498
83Neoplasm of the peripheral nervous system (HP:0100007)2.09307394
84Seborrheic dermatitis (HP:0001051)2.09209697
85Testicular atrophy (HP:0000029)2.09083873
86Neuroendocrine neoplasm (HP:0100634)2.08818300
87Increased hepatocellular lipid droplets (HP:0006565)2.08735461
88Symptomatic seizures (HP:0011145)2.07882047
89Confusion (HP:0001289)2.07646419
90Increased CSF lactate (HP:0002490)2.06910596
91Papillary thyroid carcinoma (HP:0002895)2.06212898
9211 pairs of ribs (HP:0000878)2.06096004
93Abnormal pancreas size (HP:0012094)2.05459834
94Pili torti (HP:0003777)2.04358287
95Decreased circulating renin level (HP:0003351)2.03886674
96Increased purine levels (HP:0004368)2.02928109
97Hyperuricemia (HP:0002149)2.02928109
98Muscle stiffness (HP:0003552)2.02647523
99Emotional lability (HP:0000712)2.02285345
100Ileus (HP:0002595)2.01879373
101Insomnia (HP:0100785)2.01484904
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00896327
103Abnormality of magnesium homeostasis (HP:0004921)2.00307266
104Central scotoma (HP:0000603)1.99949970
105Metabolic alkalosis (HP:0200114)1.99114055
106Abnormality of the salivary glands (HP:0010286)1.98582105
107Abnormal spermatogenesis (HP:0008669)1.98510336
108Increased circulating renin level (HP:0000848)1.98094920
109Hypoglycemic coma (HP:0001325)1.97696694
110Abnormality of the lower motor neuron (HP:0002366)1.96301478
111Ragged-red muscle fibers (HP:0003200)1.96173403
112Ankyloglossia (HP:0010296)1.95193483
113Craniofacial dystonia (HP:0012179)1.94748707
114Hyperparathyroidism (HP:0000843)1.94037926
115Hamartoma of the eye (HP:0010568)1.93251828
116Resting tremor (HP:0002322)1.93072104
117Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92752692
118Abnormal mitochondria in muscle tissue (HP:0008316)1.92490134
119Thyroid carcinoma (HP:0002890)1.92218738
120Generalized tonic-clonic seizures (HP:0002069)1.90759651
121Pallor (HP:0000980)1.89287381
122Gaze-evoked nystagmus (HP:0000640)1.88530699
123Morphological abnormality of the inner ear (HP:0011390)1.87672255
124Neoplasm of the adrenal cortex (HP:0100641)1.87351226
125Partial duplication of thumb phalanx (HP:0009944)1.87161629
126Abnormality of chloride homeostasis (HP:0011422)1.86578965
127Exercise intolerance (HP:0003546)1.86210640
128Neonatal death (HP:0003811)1.86080474
129Abnormality of the vocal cords (HP:0008777)1.85759809
130Atrioventricular block (HP:0001678)1.84410197
131Hypercalciuria (HP:0002150)1.84363550
132Hepatocellular necrosis (HP:0001404)1.83815717
133Nausea (HP:0002018)1.83727377
134Lactic acidosis (HP:0003128)1.83357154
135Lower limb asymmetry (HP:0100559)1.83144775
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82427235
137Respiratory failure (HP:0002878)1.81998775
138Abnormality of fatty-acid metabolism (HP:0004359)1.81874021
139Supranuclear gaze palsy (HP:0000605)1.81806573
140Delusions (HP:0000746)1.81580622
141Pointed chin (HP:0000307)1.81431201
142Menstrual irregularities (HP:0000858)1.81140135
143Subacute progressive viral hepatitis (HP:0006572)1.81080556
144Birth length less than 3rd percentile (HP:0003561)1.79758780
145Hyperphosphatemia (HP:0002905)1.79207614
146Choreoathetosis (HP:0001266)1.79197812
147Elfin facies (HP:0004428)1.78925503
148Lipid accumulation in hepatocytes (HP:0006561)1.78124374
149Spinal cord lesions (HP:0100561)1.77581877
150Syringomyelia (HP:0003396)1.77581877
151Focal dystonia (HP:0004373)1.77167807
152Dicarboxylic aciduria (HP:0003215)1.76223496
153Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76223496
154Sudden death (HP:0001699)1.76215224
155Pancreatic islet-cell hyperplasia (HP:0004510)1.75886276
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75862914
157Progressive macrocephaly (HP:0004481)1.75394342
158Nasolacrimal duct obstruction (HP:0000579)1.75090390
159Abnormality of glycine metabolism (HP:0010895)1.74654120
160Abnormality of serine family amino acid metabolism (HP:0010894)1.74654120
161CNS hypomyelination (HP:0003429)1.73881519
162Absence seizures (HP:0002121)1.73799976
163Neoplasm of the small intestine (HP:0100833)1.73442765
164Abnormal cartilage morphology (HP:0002763)1.73274921
165Status epilepticus (HP:0002133)1.73262950
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.72468094
167Goiter (HP:0000853)1.72226569
168Syncope (HP:0001279)1.72025804
169Growth hormone excess (HP:0000845)1.71567458
170Facial diplegia (HP:0001349)1.71501771
171Abnormality of renin-angiotensin system (HP:0000847)1.70965769
172Dysdiadochokinesis (HP:0002075)1.70506849
173Increased muscle lipid content (HP:0009058)1.70458388
174Postural instability (HP:0002172)1.70184446
175Athetosis (HP:0002305)1.69878993
176Torticollis (HP:0000473)1.69819020
177Focal seizures (HP:0007359)1.69082235
178Impaired vibratory sensation (HP:0002495)1.68691199
179Abnormality of vitamin metabolism (HP:0100508)1.67239952
180Sleep apnea (HP:0010535)1.67103021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.57585057
2LMTK23.79803946
3NME23.67611686
4VRK23.51648369
5PRKD33.03898301
6NTRK32.96776433
7FRK2.82708880
8SMG12.66532335
9CAMKK12.52199796
10DAPK22.51794936
11PINK12.51659716
12BUB12.23712147
13ZAK2.22105663
14EPHA42.18259723
15PKN21.96604462
16MAP2K71.92698073
17UHMK11.91338309
18STK381.89770705
19RIPK11.84942494
20BRSK11.84051034
21LATS21.82542185
22MINK11.80628714
23ERBB31.79398160
24MAP3K101.67883198
25EEF2K1.64285747
26PDK41.53123510
27PDK31.53123510
28SGK21.45573181
29PBK1.44374099
30MST41.39437758
31STK241.36139682
32MAP3K41.35240300
33DAPK11.34284531
34MAP2K61.33215396
35ARAF1.32635387
36MST1R1.32171837
37BMPR21.29002777
38MAP3K121.27987901
39KSR21.27677470
40SGK31.25016964
41CCNB11.23060526
42TESK11.21861756
43TNK21.18665578
44ALK1.18003870
45OBSCN1.15156679
46TRIB31.15025715
47MYLK1.14762402
48MAP3K21.14159200
49MAP2K41.13910034
50NEK61.12840343
51EPHA21.11266514
52CDC71.09727958
53BRSK21.08116184
54LRRK21.06475925
55NTRK11.05773259
56FGFR21.04993225
57PRKCH1.04133645
58ICK1.02892708
59ERN10.98541239
60RPS6KB20.97664897
61MAP2K30.96608653
62MAP3K130.94913978
63BMX0.94370234
64MAP3K90.92526759
65SCYL20.92145920
66CAMK10.91508840
67SIK10.91360595
68PRPF4B0.91120215
69RIPK40.89002881
70CDK150.88132156
71CDK11A0.86763239
72MAPK120.86224656
73CDK120.86171218
74ACVR1B0.84455496
75MAPKAPK30.82913576
76SGK2230.82700899
77SGK4940.82700899
78NTRK20.82665470
79PASK0.81999836
80STK38L0.81338299
81TESK20.80267798
82WNK30.79178523
83CDK180.78719745
84KSR10.77363166
85DMPK0.76021594
86TYRO30.75226351
87CAMKK20.73950613
88PRKG20.73885938
89CDC42BPA0.73843623
90FGFR40.73298576
91PDK10.72521839
92ATR0.72009645
93CDK140.71996869
94WNK10.71654340
95NEK20.71278215
96CSNK1E0.71015183
97TAOK20.70436965
98TIE10.70387930
99MAPKAPK50.68969041
100CAMK40.68687009
101BRAF0.67530532
102RPS6KB10.67371427
103CDK190.66214912
104PRKCG0.64726730
105WEE10.62605280
106FLT30.60950283
107CHEK10.60697815
108STK160.60614039
109PDPK10.59665496
110CDK40.59413671
111SRPK10.58843813
112CDK20.57895520
113TEC0.57527833
114BCKDK0.57346905
115CDK70.56239180
116MAP3K80.56102308
117SGK10.55506930
118GRK50.55450498
119PLK30.55423277
120WNK40.55153659
121CDK10.55141983
122CAMK2G0.54065425
123CHEK20.54033604
124TAF10.53444163
125MUSK0.53322894
126CAMK2B0.53284275
127PLK10.53047796
128MAPK100.51392839
129PAK10.50381899
130CDK50.50075817
131PIK3CA0.49741251
132MKNK20.49502526
133NME10.49109893
134MKNK10.47719263
135CSNK2A20.46272162
136NEK90.46166626
137RAF10.45595964
138MAP2K20.45279606
139PRKCI0.43393305
140RET0.43031259
141AURKB0.42046815
142TAOK10.41916369
143PLK40.41017994
144PAK60.40638604
145MAP3K10.39823108
146RPS6KA60.39626313
147PHKG10.39577853
148PHKG20.39577853
149PIK3CG0.39055790
150MAP3K70.38913571
151RPS6KA30.38600819
152TTK0.37787801
153CDK80.37495676
154BRD40.36422312
155PDK20.33338226
156EIF2AK10.32708634
157OXSR10.31492899
158RPS6KC10.31268883

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.66104911
2Ribosome_Homo sapiens_hsa030103.27692357
3Olfactory transduction_Homo sapiens_hsa047403.27311881
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55876158
5Synaptic vesicle cycle_Homo sapiens_hsa047212.36441773
6Circadian entrainment_Homo sapiens_hsa047132.32987370
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27972014
8Vitamin B6 metabolism_Homo sapiens_hsa007502.24807226
9Nitrogen metabolism_Homo sapiens_hsa009102.13142942
10Long-term potentiation_Homo sapiens_hsa047202.04105086
11Gastric acid secretion_Homo sapiens_hsa049711.86971455
12Propanoate metabolism_Homo sapiens_hsa006401.85978171
13Morphine addiction_Homo sapiens_hsa050321.84938931
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82953038
15Cardiac muscle contraction_Homo sapiens_hsa042601.81538570
16Insulin secretion_Homo sapiens_hsa049111.80826724
17Amphetamine addiction_Homo sapiens_hsa050311.80353458
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78715838
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75079241
20Spliceosome_Homo sapiens_hsa030401.74580363
21Nicotine addiction_Homo sapiens_hsa050331.69058393
22GABAergic synapse_Homo sapiens_hsa047271.66676100
23Cholinergic synapse_Homo sapiens_hsa047251.59039109
24Mismatch repair_Homo sapiens_hsa034301.57255246
25Proteasome_Homo sapiens_hsa030501.52927540
26Parkinsons disease_Homo sapiens_hsa050121.49944240
27Fatty acid degradation_Homo sapiens_hsa000711.49284284
28Glutamatergic synapse_Homo sapiens_hsa047241.48378803
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46214966
30Arginine and proline metabolism_Homo sapiens_hsa003301.44972588
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44766834
32Phenylalanine metabolism_Homo sapiens_hsa003601.43036134
33Dopaminergic synapse_Homo sapiens_hsa047281.41032447
34Carbon metabolism_Homo sapiens_hsa012001.39654075
35Vitamin digestion and absorption_Homo sapiens_hsa049771.38844311
36Calcium signaling pathway_Homo sapiens_hsa040201.35847250
37DNA replication_Homo sapiens_hsa030301.33294716
38Fatty acid elongation_Homo sapiens_hsa000621.32579005
39Sulfur relay system_Homo sapiens_hsa041221.31798105
40One carbon pool by folate_Homo sapiens_hsa006701.31446243
41Thyroid hormone synthesis_Homo sapiens_hsa049181.26290107
42Salivary secretion_Homo sapiens_hsa049701.25913476
43Oocyte meiosis_Homo sapiens_hsa041141.24340963
44Fat digestion and absorption_Homo sapiens_hsa049751.21782272
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19775598
46Folate biosynthesis_Homo sapiens_hsa007901.19434265
47Histidine metabolism_Homo sapiens_hsa003401.18257317
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16159274
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.15905649
50RNA polymerase_Homo sapiens_hsa030201.14619515
51cAMP signaling pathway_Homo sapiens_hsa040241.12064112
52Oxytocin signaling pathway_Homo sapiens_hsa049211.09423282
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07256806
54Glutathione metabolism_Homo sapiens_hsa004801.04944622
55Glucagon signaling pathway_Homo sapiens_hsa049221.01764380
56Homologous recombination_Homo sapiens_hsa034400.99636484
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99531924
58Huntingtons disease_Homo sapiens_hsa050160.98287961
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98218177
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97977323
61Tyrosine metabolism_Homo sapiens_hsa003500.96984676
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96035473
63Taste transduction_Homo sapiens_hsa047420.95964575
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92641775
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92145446
66Type I diabetes mellitus_Homo sapiens_hsa049400.90777208
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90504850
68RNA degradation_Homo sapiens_hsa030180.90243617
69Type II diabetes mellitus_Homo sapiens_hsa049300.87377647
70Pentose phosphate pathway_Homo sapiens_hsa000300.87077609
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.86349949
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84959289
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84044444
74GnRH signaling pathway_Homo sapiens_hsa049120.83951919
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80523109
76Mineral absorption_Homo sapiens_hsa049780.80304833
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78006376
78Base excision repair_Homo sapiens_hsa034100.77920854
79Non-homologous end-joining_Homo sapiens_hsa034500.77462325
80Non-small cell lung cancer_Homo sapiens_hsa052230.76644371
81RNA transport_Homo sapiens_hsa030130.75702366
82mRNA surveillance pathway_Homo sapiens_hsa030150.74878980
83Bile secretion_Homo sapiens_hsa049760.74477579
84Alzheimers disease_Homo sapiens_hsa050100.73867493
85Fatty acid metabolism_Homo sapiens_hsa012120.73224403
86Purine metabolism_Homo sapiens_hsa002300.72473504
87Thyroid cancer_Homo sapiens_hsa052160.71975110
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70779472
89Glioma_Homo sapiens_hsa052140.69428588
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67813880
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66048620
92Biosynthesis of amino acids_Homo sapiens_hsa012300.65731451
93Cocaine addiction_Homo sapiens_hsa050300.65217971
94Pyruvate metabolism_Homo sapiens_hsa006200.65149794
95Dilated cardiomyopathy_Homo sapiens_hsa054140.64939726
96beta-Alanine metabolism_Homo sapiens_hsa004100.64872520
97Renin-angiotensin system_Homo sapiens_hsa046140.64090278
98Renin secretion_Homo sapiens_hsa049240.63985470
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63110720
100Cell cycle_Homo sapiens_hsa041100.62938512
101Caffeine metabolism_Homo sapiens_hsa002320.60991416
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59917383
103Metabolic pathways_Homo sapiens_hsa011000.57749308
104Galactose metabolism_Homo sapiens_hsa000520.57623080
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56600026
106Starch and sucrose metabolism_Homo sapiens_hsa005000.56516005
107Arginine biosynthesis_Homo sapiens_hsa002200.56400961
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55127127
109Insulin resistance_Homo sapiens_hsa049310.52698949
110Butanoate metabolism_Homo sapiens_hsa006500.52507131
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52409716
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51775748
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51421366
114Sulfur metabolism_Homo sapiens_hsa009200.51095274
115Insulin signaling pathway_Homo sapiens_hsa049100.50939030
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.49377774
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49155054
118Oxidative phosphorylation_Homo sapiens_hsa001900.48575132
119Endometrial cancer_Homo sapiens_hsa052130.46861693
120Retinol metabolism_Homo sapiens_hsa008300.44674497
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42883968
122Prion diseases_Homo sapiens_hsa050200.41777740
123Chemical carcinogenesis_Homo sapiens_hsa052040.41098710
124Collecting duct acid secretion_Homo sapiens_hsa049660.40515726
125Fructose and mannose metabolism_Homo sapiens_hsa000510.40399748
126N-Glycan biosynthesis_Homo sapiens_hsa005100.40249788
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.37787665
128Melanogenesis_Homo sapiens_hsa049160.37066112
129HIF-1 signaling pathway_Homo sapiens_hsa040660.35737676
130Long-term depression_Homo sapiens_hsa047300.35213104
131Nucleotide excision repair_Homo sapiens_hsa034200.33668352
132Gap junction_Homo sapiens_hsa045400.33458754
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.32476548
134Prolactin signaling pathway_Homo sapiens_hsa049170.32123862
135Platelet activation_Homo sapiens_hsa046110.31616534
136Pancreatic secretion_Homo sapiens_hsa049720.29825586
137Pyrimidine metabolism_Homo sapiens_hsa002400.29499101
138Inositol phosphate metabolism_Homo sapiens_hsa005620.28681259

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