MT-ND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.77305544
2synaptic vesicle maturation (GO:0016188)4.53107568
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.43595643
4positive regulation of synapse maturation (GO:0090129)4.38392111
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.28759416
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21296603
7NADH metabolic process (GO:0006734)4.11659010
8neuronal action potential propagation (GO:0019227)3.93499673
9vocalization behavior (GO:0071625)3.92878950
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.75632180
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72943719
12glutamate secretion (GO:0014047)3.70998648
13sodium ion export (GO:0071436)3.67531210
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64251421
15cellular potassium ion homeostasis (GO:0030007)3.63222431
16regulation of synaptic vesicle exocytosis (GO:2000300)3.62568078
17gamma-aminobutyric acid transport (GO:0015812)3.61429629
18regulation of glutamate receptor signaling pathway (GO:1900449)3.61407122
19amino acid import (GO:0043090)3.60851549
20layer formation in cerebral cortex (GO:0021819)3.58068288
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.56952163
22creatine metabolic process (GO:0006600)3.56920767
23oxaloacetate metabolic process (GO:0006107)3.56313907
24synaptic vesicle exocytosis (GO:0016079)3.52313963
25regulation of synapse structural plasticity (GO:0051823)3.46570303
26regulation of synapse maturation (GO:0090128)3.45670148
27neurotransmitter secretion (GO:0007269)3.45080978
28potassium ion import (GO:0010107)3.38358351
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.37652662
30dendritic spine morphogenesis (GO:0060997)3.37147549
31cell communication by electrical coupling (GO:0010644)3.35252612
32activation of protein kinase A activity (GO:0034199)3.35240932
33regulation of female receptivity (GO:0045924)3.29783156
34negative regulation of dendrite morphogenesis (GO:0050774)3.28834635
35glycine transport (GO:0015816)3.28576665
36regulation of synaptic vesicle transport (GO:1902803)3.28174213
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28038811
38regulation of neuronal synaptic plasticity (GO:0048168)3.27091601
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.26815950
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.25602132
41exploration behavior (GO:0035640)3.25486894
42myelin maintenance (GO:0043217)3.24417864
43negative regulation of erythrocyte differentiation (GO:0045647)3.23480617
44positive regulation of Rap GTPase activity (GO:0032854)3.21130526
45cell communication involved in cardiac conduction (GO:0086065)3.12516642
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.08707273
47regulation of dendritic spine morphogenesis (GO:0061001)3.06614180
48neuromuscular process controlling balance (GO:0050885)2.98883559
49long-term memory (GO:0007616)2.97285263
50neurotransmitter-gated ion channel clustering (GO:0072578)2.95294413
51neuromuscular process controlling posture (GO:0050884)2.94438756
52proline transport (GO:0015824)2.94319303
53regulation of membrane repolarization (GO:0060306)2.91710465
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90731271
55cell volume homeostasis (GO:0006884)2.89018143
56response to parathyroid hormone (GO:0071107)2.88792705
57axon ensheathment in central nervous system (GO:0032291)2.86919699
58central nervous system myelination (GO:0022010)2.86919699
59negative regulation of potassium ion transmembrane transport (GO:1901380)2.86502853
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85216432
61vitamin transmembrane transport (GO:0035461)2.85061382
62protein localization to synapse (GO:0035418)2.84904725
63neurotransmitter transport (GO:0006836)2.84203999
64chemosensory behavior (GO:0007635)2.82822622
65regulation of mitotic spindle organization (GO:0060236)2.82321228
66synaptic transmission, glutamatergic (GO:0035249)2.80972167
67cardiac conduction (GO:0061337)2.79790412
68prepulse inhibition (GO:0060134)2.78989057
69glutamate receptor signaling pathway (GO:0007215)2.78550378
70positive regulation of membrane potential (GO:0045838)2.77281455
71mating behavior (GO:0007617)2.76423334
72cellular sodium ion homeostasis (GO:0006883)2.75968682
73potassium ion homeostasis (GO:0055075)2.75677981
74positive regulation of potassium ion transmembrane transport (GO:1901381)2.74923798
75sodium ion homeostasis (GO:0055078)2.73210635
76L-amino acid import (GO:0043092)2.72733607
77peptidyl-tyrosine autophosphorylation (GO:0038083)2.72399775
78cerebellar Purkinje cell layer development (GO:0021680)2.70202999
79regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.69821507
80neuron-neuron synaptic transmission (GO:0007270)2.69633166
81regulation of neurotransmitter levels (GO:0001505)2.69362549
82positive regulation of dendritic spine morphogenesis (GO:0061003)2.69308612
83auditory behavior (GO:0031223)2.68870378
84transmission of nerve impulse (GO:0019226)2.68448364
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67462456
86gamma-aminobutyric acid signaling pathway (GO:0007214)2.66659195
87female mating behavior (GO:0060180)2.66513880
88membrane repolarization (GO:0086009)2.66356263
89regulation of early endosome to late endosome transport (GO:2000641)2.66193727
90positive regulation of cellular amine metabolic process (GO:0033240)2.64631765
91regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.64559007
92signal complex assembly (GO:0007172)2.64344109
93positive regulation of potassium ion transport (GO:0043268)2.64213966
94regulation of voltage-gated calcium channel activity (GO:1901385)2.64101729
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63744582
96triglyceride catabolic process (GO:0019433)2.63571613
97regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62824214
98neuron cell-cell adhesion (GO:0007158)2.61389706
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61309536
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61305579
101positive regulation of sodium ion transport (GO:0010765)2.59687053
102neuronal ion channel clustering (GO:0045161)2.59580878
103long-term synaptic potentiation (GO:0060291)2.58210256
104regulation of oxidative phosphorylation (GO:0002082)2.58158288
105regulation of clathrin-mediated endocytosis (GO:2000369)2.58139886
106regulation of ARF protein signal transduction (GO:0032012)2.57989448
107aspartate family amino acid catabolic process (GO:0009068)2.57372489
108phosphate ion transmembrane transport (GO:0035435)2.57058375
109positive regulation of protein dephosphorylation (GO:0035307)2.57047728
110dopamine receptor signaling pathway (GO:0007212)2.56738163
111acylglycerol catabolic process (GO:0046464)2.55767731
112neutral lipid catabolic process (GO:0046461)2.55767731
113dendrite morphogenesis (GO:0048813)2.55174371
114regulation of cell communication by electrical coupling (GO:0010649)2.55126519
115lysine catabolic process (GO:0006554)2.54927914
116lysine metabolic process (GO:0006553)2.54927914
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54767907
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54173325
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52867505
120regulation of protein dephosphorylation (GO:0035304)2.52408682
121regulation of histone H3-K27 methylation (GO:0061085)2.52205912
122regulation of dendritic spine development (GO:0060998)2.51343416
123detection of calcium ion (GO:0005513)2.51303034
124behavioral response to cocaine (GO:0048148)2.51145470
125regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.51073879
126membrane depolarization during action potential (GO:0086010)2.50601678
127regulation of Rap GTPase activity (GO:0032317)2.49783226
128regulation of vesicle fusion (GO:0031338)2.49143084
129dicarboxylic acid biosynthetic process (GO:0043650)2.48907690
130regulation of heart rate by cardiac conduction (GO:0086091)2.47218604
131ventricular cardiac muscle cell action potential (GO:0086005)2.46667270
132neurotransmitter uptake (GO:0001504)2.45607808
133regulation of postsynaptic membrane potential (GO:0060078)2.45585579
134regulation of calcium ion transmembrane transporter activity (GO:1901019)2.45558259
135regulation of calcium ion transmembrane transport (GO:1903169)2.45558259
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.45332625
137regulation of synaptic plasticity (GO:0048167)2.44511854
138carnitine shuttle (GO:0006853)2.42490900
139regulation of ion transmembrane transporter activity (GO:0032412)2.41933499
140positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.40647998
141alanine transport (GO:0032328)2.40392894
142cerebellar Purkinje cell differentiation (GO:0021702)2.40345990
143plasma membrane repair (GO:0001778)2.40316890
144positive regulation of dendritic spine development (GO:0060999)2.40199910
145glutamate metabolic process (GO:0006536)2.39821704
146cerebellar granule cell differentiation (GO:0021707)2.39344844
147ethanol oxidation (GO:0006069)2.37557518
148regulation of neurotransmitter secretion (GO:0046928)2.35079965
149water transport (GO:0006833)2.34443769
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34286603
151L-phenylalanine metabolic process (GO:0006558)2.34286603
152synaptic vesicle endocytosis (GO:0048488)2.34134245
153adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.33032542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48340596
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69588742
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56773432
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54367413
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49653868
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49653868
7DROSHA_22980978_ChIP-Seq_HELA_Human2.33821826
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33624300
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.30803866
10LXR_22292898_ChIP-Seq_THP-1_Human2.27992555
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23208166
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21798790
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16314303
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13236140
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.03681309
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03076181
17REST_21632747_ChIP-Seq_MESCs_Mouse2.02588326
18GBX2_23144817_ChIP-Seq_PC3_Human2.01196187
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.98267622
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94945633
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93934299
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89039936
23RACK7_27058665_Chip-Seq_MCF-7_Human1.88854142
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85898593
25SMC4_20622854_ChIP-Seq_HELA_Human1.84661135
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.82237247
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.79913501
28TCF7_22412390_ChIP-Seq_EML_Mouse1.79845702
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.79708443
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78402273
31CREB1_26743006_Chip-Seq_LNCaP_Human1.77103532
32CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.72502613
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72286044
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72161726
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.71290158
36P68_20966046_ChIP-Seq_HELA_Human1.65969357
37KDM2B_26808549_Chip-Seq_DND41_Human1.64580119
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.64551392
39AR_21572438_ChIP-Seq_LNCaP_Human1.64504585
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61204220
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60861097
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59560036
43MYC_22102868_ChIP-Seq_BL_Human1.58663715
44CLOCK_20551151_ChIP-Seq_293T_Human1.55657306
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51036234
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50164328
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.49559026
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49196358
49GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.47490347
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46518528
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43296991
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42296427
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41433588
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40222506
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.36554992
56ZNF263_19887448_ChIP-Seq_K562_Human1.36548784
57ZNF274_21170338_ChIP-Seq_K562_Hela1.33336202
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33138959
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32324979
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.30943002
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30185751
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28042023
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27993514
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27955266
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26867117
66FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26269844
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.25135589
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24915103
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.23696990
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.22811266
71SMAD4_21799915_ChIP-Seq_A2780_Human1.22809305
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22152327
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22131326
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21192096
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.20784901
76KDM2B_26808549_Chip-Seq_K562_Human1.20768626
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18700436
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17801665
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.17332766
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.16891786
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.16314137
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16137361
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.15923108
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14900971
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13905604
86NCOR1_26117541_ChIP-Seq_K562_Human1.13581377
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.13482934
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12794946
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.12484529
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.12484529
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11865605
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11826065
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.11557288
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11400416
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11289447
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11087653
97OCT4_19829295_ChIP-Seq_ESCs_Human1.10816327
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10448926
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10083009
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09852142
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08322649
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07664411
103AR_19668381_ChIP-Seq_PC3_Human1.07417151
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.06494661
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06349931
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05779169
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05661909
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05325722
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04970430
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04315682
111GATA1_19941826_ChIP-Seq_K562_Human1.03937286
112SA1_27219007_Chip-Seq_Bcells_Human1.03355385
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03286669
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.02588986
115TAF15_26573619_Chip-Seq_HEK293_Human1.02361192
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.01489153
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.00596197
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.00221926
119RXR_22108803_ChIP-Seq_LS180_Human1.00125988
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99954700
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98986291
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98955397
123CTCF_27219007_Chip-Seq_Bcells_Human0.98898014
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.98829649
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98166802
126STAT3_23295773_ChIP-Seq_U87_Human0.97858925
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97779067
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.97649640
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.97641827
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97565611
131TP63_22573176_ChIP-Seq_HFKS_Human0.95535706
132AHR_22903824_ChIP-Seq_MCF-7_Human0.95493439
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95202351
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94704856
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94590624
136AR_25329375_ChIP-Seq_VCAP_Human0.94136452
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93931999
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.93676671
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93477446
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93083992
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.92899857
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90485200
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.89224075
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89154068
145TP53_16413492_ChIP-PET_HCT116_Human0.88345685
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88271034
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87616274
148KLF4_19829295_ChIP-Seq_ESCs_Human0.87086382
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84562493
150FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84223987
151BCAT_22108803_ChIP-Seq_LS180_Human0.84103206
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.83990047
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83938438
154PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83413489
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83091372
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80983622
157TET1_21490601_ChIP-Seq_MESCs_Mouse0.80959515
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80922966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.21762586
2MP0003635_abnormal_synaptic_transmissio3.22418060
3MP0005670_abnormal_white_adipose3.17209404
4MP0003880_abnormal_central_pattern3.05644702
5MP0004270_analgesia3.00272054
6MP0002822_catalepsy2.98578144
7MP0009745_abnormal_behavioral_response2.58091400
8MP0004043_abnormal_pH_regulation2.57221310
9MP0000751_myopathy2.43765690
10MP0002063_abnormal_learning/memory/cond2.40801382
11MP0002064_seizures2.39916955
12MP0009046_muscle_twitch2.37383160
13MP0002837_dystrophic_cardiac_calcinosis2.37319360
14MP0001486_abnormal_startle_reflex2.17487501
15MP0004215_abnormal_myocardial_fiber2.11235693
16MP0003123_paternal_imprinting2.08996906
17MP0000678_abnormal_parathyroid_gland2.05949055
18MP0009780_abnormal_chondrocyte_physiolo2.04350972
19MP0005423_abnormal_somatic_nervous2.04231476
20MP0002272_abnormal_nervous_system2.03849487
21MP0003646_muscle_fatigue2.01975996
22MP0004145_abnormal_muscle_electrophysio1.99100646
23MP0002909_abnormal_adrenal_gland1.93934700
24MP0002734_abnormal_mechanical_nocicepti1.89586721
25MP0002572_abnormal_emotion/affect_behav1.88742016
26MP0003329_amyloid_beta_deposits1.87183314
27MP0004885_abnormal_endolymph1.87029148
28MP0001502_abnormal_circadian_rhythm1.81870160
29MP0005360_urolithiasis1.80238443
30MP0005409_darkened_coat_color1.76108782
31MP0001440_abnormal_grooming_behavior1.75640964
32MP0001501_abnormal_sleep_pattern1.73442522
33MP0008569_lethality_at_weaning1.70693010
34MP0004084_abnormal_cardiac_muscle1.68750548
35MP0004036_abnormal_muscle_relaxation1.66940694
36MP0004130_abnormal_muscle_cell1.65920937
37MP0001968_abnormal_touch/_nociception1.65516421
38MP0005085_abnormal_gallbladder_physiolo1.55892634
39MP0004484_altered_response_of1.49561225
40MP0002139_abnormal_hepatobiliary_system1.46898293
41MP0004019_abnormal_vitamin_homeostasis1.43104031
42MP0003690_abnormal_glial_cell1.42843099
43MP0008961_abnormal_basal_metabolism1.42234212
44MP0002067_abnormal_sensory_capabilities1.40870520
45MP0000747_muscle_weakness1.39203895
46MP0003137_abnormal_impulse_conducting1.39090895
47MP0005330_cardiomyopathy1.38082262
48MP0005386_behavior/neurological_phenoty1.36545416
49MP0004924_abnormal_behavior1.36545416
50MP0003879_abnormal_hair_cell1.35517141
51MP0002796_impaired_skin_barrier1.33294516
52MP0009672_abnormal_birth_weight1.31761502
53MP0004085_abnormal_heartbeat1.30894901
54MP0001970_abnormal_pain_threshold1.28873910
55MP0003195_calcinosis1.27765318
56MP0005535_abnormal_body_temperature1.27584789
57MP0002733_abnormal_thermal_nociception1.25983420
58MP0005620_abnormal_muscle_contractility1.25547512
59* MP0006036_abnormal_mitochondrial_physio1.23861525
60MP0003633_abnormal_nervous_system1.18682255
61MP0002066_abnormal_motor_capabilities/c1.16550237
62MP0001346_abnormal_lacrimal_gland1.16463618
63MP0005332_abnormal_amino_acid1.15400134
64MP0000013_abnormal_adipose_tissue1.15370224
65MP0002249_abnormal_larynx_morphology1.14901220
66MP0004087_abnormal_muscle_fiber1.14860772
67MP0008875_abnormal_xenobiotic_pharmacok1.14419935
68MP0002557_abnormal_social/conspecific_i1.13446637
69MP0005167_abnormal_blood-brain_barrier1.13399836
70MP0004858_abnormal_nervous_system1.12733206
71MP0003172_abnormal_lysosome_physiology1.12661619
72MP0002972_abnormal_cardiac_muscle1.10139246
73MP0002184_abnormal_innervation1.09420816
74MP0005646_abnormal_pituitary_gland1.09283850
75MP0000920_abnormal_myelination1.04808561
76MP0001485_abnormal_pinna_reflex1.03749338
77MP0003868_abnormal_feces_composition1.03048003
78MP0000955_abnormal_spinal_cord1.02660818
79MP0002736_abnormal_nociception_after1.02074495
80MP0004811_abnormal_neuron_physiology1.01949763
81MP0009115_abnormal_fat_cell1.00809905
82MP0000003_abnormal_adipose_tissue1.00287832
83MP0000566_synostosis0.99992854
84MP0002735_abnormal_chemical_nociception0.99943013
85MP0006138_congestive_heart_failure0.99320499
86MP0008775_abnormal_heart_ventricle0.99242701
87MP0005365_abnormal_bile_salt0.98479462
88MP0000778_abnormal_nervous_system0.97791751
89MP0002970_abnormal_white_adipose0.97635065
90MP0000749_muscle_degeneration0.96893309
91MP0005623_abnormal_meninges_morphology0.96016528
92MP0005666_abnormal_adipose_tissue0.95940708
93MP0010630_abnormal_cardiac_muscle0.94599312
94MP0002106_abnormal_muscle_physiology0.94350096
95MP0004185_abnormal_adipocyte_glucose0.92635541
96MP0005448_abnormal_energy_balance0.92580119
97MP0002882_abnormal_neuron_morphology0.92086079
98MP0003631_nervous_system_phenotype0.90878807
99MP0002876_abnormal_thyroid_physiology0.89306338
100MP0010329_abnormal_lipoprotein_level0.89195689
101MP0010234_abnormal_vibrissa_follicle0.88853382
102MP0004233_abnormal_muscle_weight0.88653146
103MP0004142_abnormal_muscle_tone0.88261719
104MP0001765_abnormal_ion_homeostasis0.87622389
105MP0008872_abnormal_physiological_respon0.87446820
106MP0001666_abnormal_nutrient_absorption0.87131890
107MP0003283_abnormal_digestive_organ0.86997641
108MP0008874_decreased_physiological_sensi0.86349927
109MP0002118_abnormal_lipid_homeostasis0.85754467
110MP0003075_altered_response_to0.85601255
111MP0002396_abnormal_hematopoietic_system0.84859107
112MP0005187_abnormal_penis_morphology0.83848488
113MP0005452_abnormal_adipose_tissue0.83654528
114MP0002069_abnormal_eating/drinking_beha0.83555441
115MP0005369_muscle_phenotype0.82605531
116MP0002078_abnormal_glucose_homeostasis0.81469115
117MP0003787_abnormal_imprinting0.81418351
118MP0001984_abnormal_olfaction0.81162012
119MP0002269_muscular_atrophy0.80790746
120MP0001730_embryonic_growth_arrest0.80691510
121MP0003252_abnormal_bile_duct0.79990185
122MP0000230_abnormal_systemic_arterial0.79399979
123MP0001177_atelectasis0.78857107
124MP0000604_amyloidosis0.78809296
125MP0002971_abnormal_brown_adipose0.78463189
126MP0005375_adipose_tissue_phenotype0.77974516
127MP0002229_neurodegeneration0.77605809
128MP0004264_abnormal_extraembryonic_tissu0.77522758
129MP0005166_decreased_susceptibility_to0.75853785
130MP0005385_cardiovascular_system_phenoty0.75171017
131MP0001544_abnormal_cardiovascular_syste0.75171017
132MP0002089_abnormal_postnatal_growth/wei0.74137573
133MP0005058_abnormal_lysosome_morphology0.73732273
134MP0003953_abnormal_hormone_level0.72781226
135MP0001731_abnormal_postnatal_growth0.71552044
136MP0000681_abnormal_thyroid_gland0.71331952
137MP0003183_abnormal_peptide_metabolism0.71197722
138MP0005636_abnormal_mineral_homeostasis0.70741708
139MP0003045_fibrosis0.70490498
140MP0005334_abnormal_fat_pad0.69805576

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.18228139
2Focal motor seizures (HP:0011153)5.12552244
3Obstructive sleep apnea (HP:0002870)4.60044301
4Ventricular fibrillation (HP:0001663)4.08698869
5Visual hallucinations (HP:0002367)3.93192695
6Bundle branch block (HP:0011710)3.87781784
7Focal seizures (HP:0007359)3.80061938
8Exercise-induced myalgia (HP:0003738)3.56018808
9Diplopia (HP:0000651)3.49947481
10Abnormality of binocular vision (HP:0011514)3.49947481
11Action tremor (HP:0002345)3.47717536
12Sudden death (HP:0001699)3.33066470
13Gout (HP:0001997)3.03575731
14Truncus arteriosus (HP:0001660)3.01142660
15Dysdiadochokinesis (HP:0002075)2.97372159
16Annular pancreas (HP:0001734)2.96886259
17Generalized tonic-clonic seizures (HP:0002069)2.96521030
18Increased circulating renin level (HP:0000848)2.93353090
19Heart block (HP:0012722)2.84812803
20Absence seizures (HP:0002121)2.81976356
21Atrioventricular block (HP:0001678)2.80947416
22Progressive cerebellar ataxia (HP:0002073)2.77531037
23Syncope (HP:0001279)2.77250570
24Atonic seizures (HP:0010819)2.76538002
25Impaired social interactions (HP:0000735)2.73522268
26Abnormal social behavior (HP:0012433)2.73522268
27Hypercortisolism (HP:0001578)2.71097885
28Dysmetria (HP:0001310)2.66898483
29Exercise-induced muscle cramps (HP:0003710)2.66253378
30Poor eye contact (HP:0000817)2.65705090
31Broad-based gait (HP:0002136)2.65422544
32Anxiety (HP:0000739)2.65006660
33Calf muscle hypertrophy (HP:0008981)2.62560870
34Prolonged QT interval (HP:0001657)2.60270071
35Intention tremor (HP:0002080)2.59784892
36Ketoacidosis (HP:0001993)2.59613187
37Hyperglycinuria (HP:0003108)2.58664130
38Muscle hypertrophy of the lower extremities (HP:0008968)2.58514968
39Cerebral hypomyelination (HP:0006808)2.58084672
40Postural instability (HP:0002172)2.56571558
41Abnormal atrioventricular conduction (HP:0005150)2.56028887
42Impaired vibration sensation in the lower limbs (HP:0002166)2.55374051
43Growth hormone excess (HP:0000845)2.55129765
44Hyperactive renin-angiotensin system (HP:0000841)2.54393039
45Muscle fiber splitting (HP:0003555)2.53822313
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.52737454
47Depression (HP:0000716)2.51358857
48Ankle clonus (HP:0011448)2.50213455
49Atrial fibrillation (HP:0005110)2.49967766
50Difficulty running (HP:0009046)2.49029763
51Supranuclear gaze palsy (HP:0000605)2.48987219
52Dialeptic seizures (HP:0011146)2.48409230
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47523849
54Hyperthyroidism (HP:0000836)2.46833385
55Neuronal loss in central nervous system (HP:0002529)2.46805641
56Dysmetric saccades (HP:0000641)2.46078359
57Abnormality of serine family amino acid metabolism (HP:0010894)2.44315217
58Abnormality of glycine metabolism (HP:0010895)2.44315217
59Ventricular arrhythmia (HP:0004308)2.43917217
60Cholecystitis (HP:0001082)2.43403885
61Abnormal gallbladder physiology (HP:0012438)2.43403885
62Urinary urgency (HP:0000012)2.43213411
63Metabolic alkalosis (HP:0200114)2.42073509
64Primary atrial arrhythmia (HP:0001692)2.39854403
65Myoglobinuria (HP:0002913)2.39374602
66Hyperglycinemia (HP:0002154)2.39335135
67Ketosis (HP:0001946)2.37764556
68Abnormality of saccadic eye movements (HP:0000570)2.35737175
69Urinary bladder sphincter dysfunction (HP:0002839)2.34062474
70Adrenal overactivity (HP:0002717)2.33731214
71Hypokalemic alkalosis (HP:0001949)2.33084318
72Abnormal EKG (HP:0003115)2.32635661
73Hemiplegia (HP:0002301)2.32177092
74Hyperphosphatemia (HP:0002905)2.29893300
75Abnormal eating behavior (HP:0100738)2.28302099
76Hyporeflexia of lower limbs (HP:0002600)2.27766778
77Papilledema (HP:0001085)2.27599352
78Status epilepticus (HP:0002133)2.25853183
79Rigidity (HP:0002063)2.24010924
80Gaze-evoked nystagmus (HP:0000640)2.23737525
81Termporal pattern (HP:0011008)2.23650274
82Insidious onset (HP:0003587)2.23650274
83Torticollis (HP:0000473)2.22615664
84Genetic anticipation (HP:0003743)2.22076162
85Neurofibrillary tangles (HP:0002185)2.18944823
86Supraventricular tachycardia (HP:0004755)2.18716438
87Distal upper limb amyotrophy (HP:0007149)2.17324755
88Upper limb amyotrophy (HP:0009129)2.17324755
89Epileptic encephalopathy (HP:0200134)2.16930069
90Febrile seizures (HP:0002373)2.15446595
91Peripheral hypomyelination (HP:0007182)2.15237625
92Abnormality of the calf musculature (HP:0001430)2.15134553
93Progressive inability to walk (HP:0002505)2.12507326
94Supraventricular arrhythmia (HP:0005115)2.12409913
95Bradykinesia (HP:0002067)2.12229647
96Right ventricular cardiomyopathy (HP:0011663)2.11975027
97Ankyloglossia (HP:0010296)2.08236131
98Truncal ataxia (HP:0002078)2.07819127
99Cerebral inclusion bodies (HP:0100314)2.07166006
100Bowel incontinence (HP:0002607)2.05860055
101Sleep apnea (HP:0010535)2.03923075
102Urethral obstruction (HP:0000796)2.02858906
103Mutism (HP:0002300)2.02706364
104Male infertility (HP:0003251)2.01698175
105Lower limb asymmetry (HP:0100559)2.00403111
106Delusions (HP:0000746)1.98990880
107Spastic gait (HP:0002064)1.98962906
108Focal dystonia (HP:0004373)1.98042091
109Abnormality of the salivary glands (HP:0010286)1.97814326
110Hyperparathyroidism (HP:0000843)1.96722983
111Hyperaldosteronism (HP:0000859)1.96364542
112Hypoglycemic seizures (HP:0002173)1.95256944
113Pheochromocytoma (HP:0002666)1.93375560
114Hyperuricemia (HP:0002149)1.93004252
115Increased purine levels (HP:0004368)1.93004252
116Clonus (HP:0002169)1.92877558
117Scanning speech (HP:0002168)1.92020824
118Tetraplegia (HP:0002445)1.91494863
119Resting tremor (HP:0002322)1.89334157
120Abnormal large intestine physiology (HP:0012700)1.88659597
121Stereotypic behavior (HP:0000733)1.88628601
122Delayed CNS myelination (HP:0002188)1.88278656
123Slow saccadic eye movements (HP:0000514)1.87702253
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87373666
125Hyperkalemia (HP:0002153)1.86617832
126Hyperventilation (HP:0002883)1.86584811
127Abnormality of the lower motor neuron (HP:0002366)1.85482780
128Hyperammonemia (HP:0001987)1.85113726
129Ileus (HP:0002595)1.84956535
130Abnormality of the corticospinal tract (HP:0002492)1.84264070
131Renal salt wasting (HP:0000127)1.84199805
132Foot dorsiflexor weakness (HP:0009027)1.83433344
133Abnormality of ocular smooth pursuit (HP:0000617)1.81181274
134Craniofacial dystonia (HP:0012179)1.81000288
135Abnormality of the foot musculature (HP:0001436)1.80962401
136Impaired vibratory sensation (HP:0002495)1.80830086
137Bronchomalacia (HP:0002780)1.80783939
138Choreoathetosis (HP:0001266)1.80291412
139Macroorchidism (HP:0000053)1.79853035
140Rapidly progressive (HP:0003678)1.79290256
141Myotonia (HP:0002486)1.78920320
142Ventricular tachycardia (HP:0004756)1.78840920
143Polar cataract (HP:0010696)1.78416246
144Seborrheic dermatitis (HP:0001051)1.78157510
145Abnormality of the Achilles tendon (HP:0005109)1.76438661
146Hemiparesis (HP:0001269)1.75903372
147Abnormality of glycolysis (HP:0004366)1.75544022
148Abnormality of chloride homeostasis (HP:0011422)1.74988763
149Hand muscle atrophy (HP:0009130)1.74934278
150Insomnia (HP:0100785)1.74074433
151Hypoglycemic coma (HP:0001325)1.74013921
152Increased variability in muscle fiber diameter (HP:0003557)1.73343505
153Abnormality of renin-angiotensin system (HP:0000847)1.72673458
154Muscle stiffness (HP:0003552)1.72097613
155Postural tremor (HP:0002174)1.71341785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.62582817
2NTRK33.30131701
3MAP3K93.10177564
4PRPF4B3.00010962
5CDK122.86112793
6PRKD32.54936286
7PAK62.37663500
8DAPK22.26100865
9MAP3K42.23154613
10KSR22.16590083
11WNK42.11823338
12MARK12.03481838
13PHKG12.03146407
14PHKG22.03146407
15STK382.02455468
16MAP2K41.94017159
17OXSR11.90979335
18STK391.84192011
19MINK11.79857046
20CAMKK11.76978953
21LMTK21.69396918
22PINK11.67681026
23TRIB31.65622433
24SMG11.58179673
25NTRK21.56506792
26NTRK11.51622081
27BRSK11.46649239
28TYRO31.42310253
29WNK11.40542434
30PAK31.39547032
31PDK31.38919076
32PDK41.38919076
33NEK11.37930020
34TAOK11.34566337
35DAPK11.34437509
36MAP3K21.32855433
37MAP2K71.27526532
38ERN11.26759098
39CDK51.26506831
40SIK11.24851865
41STK111.18711322
42MST41.17246934
43TNK21.15792443
44NEK61.13580791
45WNK31.11639911
46RIPK11.10785030
47DMPK1.10674597
48CAMK1G1.09650502
49PRKCH1.09167332
50FGFR31.08805771
51LATS21.07058599
52MST1R1.04910271
53FGFR41.02688215
54BMPR21.02155111
55ALK1.01872862
56EIF2AK11.01384274
57PDPK11.00720279
58SIK30.98614959
59EEF2K0.97209836
60CAMK10.96940097
61SGK2230.96863422
62SGK4940.96863422
63KSR10.96347369
64BMX0.95720920
65NME10.94807141
66PNCK0.94247324
67MAP3K70.92894460
68RET0.90670635
69PRKCG0.90539156
70MAPKAPK30.89178046
71HIPK20.88797366
72MAP3K130.88749533
73UHMK10.88511078
74BRD40.87803820
75PDK10.86381946
76CAMK2A0.86073049
77GRK50.82770569
78MAP2K60.79982513
79EPHA20.78146454
80SIK20.76285131
81SGK30.76204776
82CAMKK20.75931982
83SGK10.75839649
84OBSCN0.75348455
85CAMK2G0.74385404
86RIPK40.74288537
87TTN0.73721970
88FES0.73410194
89CDC42BPA0.72752239
90CAMK2D0.70177818
91TNIK0.69104090
92PDK20.68637277
93MAP3K10.66994358
94PRKG20.66679476
95CAMK2B0.66509728
96FGFR20.66427837
97PRKD10.65711946
98ARAF0.65701668
99PKN20.65210972
100CDK190.64057421
101TAOK20.61044540
102RPS6KA30.60593896
103BCKDK0.59083247
104TTK0.58809400
105CDK11A0.58479373
106CSNK1G20.58401007
107PDGFRA0.58358828
108SGK20.57718189
109STK240.57457375
110MARK20.56782177
111PTK2B0.56464814
112MAP2K10.54036048
113MTOR0.52941050
114MUSK0.52492310
115CAMK40.52156416
116PRKAA10.52052348
117CAMK1D0.51784292
118DYRK1A0.49753332
119FER0.49412106
120MAPK100.49166064
121PRKCZ0.48668426
122MAPK120.47724918
123CDK150.47512049
124CDK140.46937215
125ICK0.46623072
126PTK20.45755805
127TESK10.45612080
128PRKACG0.45599057
129CDK90.44404933
130PRKCE0.43945889
131SCYL20.43817437
132MAPKAPK50.43539831
133CSNK1E0.43275677
134PRKAA20.42992061
135MAP3K100.42830404
136GSK3B0.41270713
137CDK180.41235023
138RAF10.41136490
139MAPK110.39994169
140MAPK70.39734899

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.25266071
2Nicotine addiction_Homo sapiens_hsa050332.20116363
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12521062
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99217800
5GABAergic synapse_Homo sapiens_hsa047271.98273293
6Olfactory transduction_Homo sapiens_hsa047401.89940048
7Butanoate metabolism_Homo sapiens_hsa006501.85818013
8Synaptic vesicle cycle_Homo sapiens_hsa047211.82780237
9Glutamatergic synapse_Homo sapiens_hsa047241.81892474
10Circadian entrainment_Homo sapiens_hsa047131.81481424
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78903222
12Histidine metabolism_Homo sapiens_hsa003401.76369144
13Long-term potentiation_Homo sapiens_hsa047201.75449783
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72534295
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.71827934
16Phenylalanine metabolism_Homo sapiens_hsa003601.71317530
17Gastric acid secretion_Homo sapiens_hsa049711.68998368
18Morphine addiction_Homo sapiens_hsa050321.66149450
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62416481
20Arginine biosynthesis_Homo sapiens_hsa002201.61837373
21Amphetamine addiction_Homo sapiens_hsa050311.61713938
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61069369
23Salivary secretion_Homo sapiens_hsa049701.60574178
24Insulin secretion_Homo sapiens_hsa049111.58945898
25Propanoate metabolism_Homo sapiens_hsa006401.58897857
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58050088
27Cardiac muscle contraction_Homo sapiens_hsa042601.56326353
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54107430
29Fatty acid degradation_Homo sapiens_hsa000711.42257538
30Bile secretion_Homo sapiens_hsa049761.40923314
31Dopaminergic synapse_Homo sapiens_hsa047281.38023805
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34472759
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33797136
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32573373
35Cholinergic synapse_Homo sapiens_hsa047251.28804760
36Fatty acid metabolism_Homo sapiens_hsa012121.27430784
37Renin secretion_Homo sapiens_hsa049241.24937514
38Oxytocin signaling pathway_Homo sapiens_hsa049211.22904472
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22081788
40Arginine and proline metabolism_Homo sapiens_hsa003301.21966205
41Calcium signaling pathway_Homo sapiens_hsa040201.15768449
42Dilated cardiomyopathy_Homo sapiens_hsa054141.13895082
43Cocaine addiction_Homo sapiens_hsa050301.12907267
44Taste transduction_Homo sapiens_hsa047421.11714291
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11595855
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08171596
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.06809184
48cAMP signaling pathway_Homo sapiens_hsa040241.05355876
49Long-term depression_Homo sapiens_hsa047301.03764015
50GnRH signaling pathway_Homo sapiens_hsa049121.03204196
51Type II diabetes mellitus_Homo sapiens_hsa049301.01403252
52PPAR signaling pathway_Homo sapiens_hsa033200.99775405
53Dorso-ventral axis formation_Homo sapiens_hsa043200.96585288
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93586840
55Oocyte meiosis_Homo sapiens_hsa041140.92764834
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90016357
57Prion diseases_Homo sapiens_hsa050200.88079485
58Gap junction_Homo sapiens_hsa045400.85783675
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85368575
60Fatty acid biosynthesis_Homo sapiens_hsa000610.84533411
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83490062
62beta-Alanine metabolism_Homo sapiens_hsa004100.82826896
63Inositol phosphate metabolism_Homo sapiens_hsa005620.81626282
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80757378
65Tryptophan metabolism_Homo sapiens_hsa003800.79870132
66Glucagon signaling pathway_Homo sapiens_hsa049220.79496665
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79262251
68Thyroid hormone synthesis_Homo sapiens_hsa049180.79026179
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.78120812
70Serotonergic synapse_Homo sapiens_hsa047260.78054718
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77708629
72Pancreatic secretion_Homo sapiens_hsa049720.76847414
73Estrogen signaling pathway_Homo sapiens_hsa049150.75128391
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75110592
75Pyruvate metabolism_Homo sapiens_hsa006200.74877453
76Tyrosine metabolism_Homo sapiens_hsa003500.74051085
77Carbon metabolism_Homo sapiens_hsa012000.72246693
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71369397
79VEGF signaling pathway_Homo sapiens_hsa043700.71246190
80Fructose and mannose metabolism_Homo sapiens_hsa000510.67741486
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67373362
82Melanogenesis_Homo sapiens_hsa049160.66444884
83Thyroid cancer_Homo sapiens_hsa052160.65942759
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65383299
85Fat digestion and absorption_Homo sapiens_hsa049750.64864717
86Glioma_Homo sapiens_hsa052140.62002275
87Vitamin digestion and absorption_Homo sapiens_hsa049770.60375544
88Collecting duct acid secretion_Homo sapiens_hsa049660.59933610
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.59617716
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59367462
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58615671
92mRNA surveillance pathway_Homo sapiens_hsa030150.57877528
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57729725
94Axon guidance_Homo sapiens_hsa043600.57020965
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.56296322
96Mineral absorption_Homo sapiens_hsa049780.55574611
97Glycerolipid metabolism_Homo sapiens_hsa005610.54945122
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53713940
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52682223
100Ovarian steroidogenesis_Homo sapiens_hsa049130.52310562
101ErbB signaling pathway_Homo sapiens_hsa040120.51886399
102Choline metabolism in cancer_Homo sapiens_hsa052310.51771819
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.51519049
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50861033
105Insulin resistance_Homo sapiens_hsa049310.50804329
106Insulin signaling pathway_Homo sapiens_hsa049100.50182882
107Alzheimers disease_Homo sapiens_hsa050100.49626166
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49549652
109Biosynthesis of amino acids_Homo sapiens_hsa012300.48982489
110Fatty acid elongation_Homo sapiens_hsa000620.48161896
111AMPK signaling pathway_Homo sapiens_hsa041520.47822341
112Vitamin B6 metabolism_Homo sapiens_hsa007500.45840701
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.45002705
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42302109
115Peroxisome_Homo sapiens_hsa041460.41500154
116Circadian rhythm_Homo sapiens_hsa047100.39890821
117mTOR signaling pathway_Homo sapiens_hsa041500.39707974
118Renal cell carcinoma_Homo sapiens_hsa052110.39492535
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39216204
120Starch and sucrose metabolism_Homo sapiens_hsa005000.39081946
121Non-small cell lung cancer_Homo sapiens_hsa052230.39010446
122Parkinsons disease_Homo sapiens_hsa050120.37939297
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37122737
124Acute myeloid leukemia_Homo sapiens_hsa052210.36920619
125Lysine degradation_Homo sapiens_hsa003100.36667668

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