MT-ND3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glutamate secretion (GO:0014047)5.22517114
2synaptic vesicle exocytosis (GO:0016079)4.86256452
3lysine catabolic process (GO:0006554)4.45921575
4lysine metabolic process (GO:0006553)4.45921575
5regulation of synaptic vesicle exocytosis (GO:2000300)4.34817742
6carnitine shuttle (GO:0006853)4.33517460
7positive regulation of synapse maturation (GO:0090129)4.33033705
8axon ensheathment in central nervous system (GO:0032291)4.21008096
9central nervous system myelination (GO:0022010)4.21008096
10cerebellar granule cell differentiation (GO:0021707)4.20046262
11fatty acid transmembrane transport (GO:1902001)4.18789523
12tricarboxylic acid cycle (GO:0006099)4.16930591
13potassium ion homeostasis (GO:0055075)4.10357007
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.82274309
15carnitine transport (GO:0015879)3.79368239
16amino-acid betaine transport (GO:0015838)3.79368239
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.77828096
182-oxoglutarate metabolic process (GO:0006103)3.76465270
19regulation of sequestering of triglyceride (GO:0010889)3.75770739
20carnitine transmembrane transport (GO:1902603)3.71605373
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69403479
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.67430952
23regulation of synaptic vesicle transport (GO:1902803)3.66319394
24aspartate family amino acid catabolic process (GO:0009068)3.63211949
25cellular sodium ion homeostasis (GO:0006883)3.58387226
26NADH metabolic process (GO:0006734)3.54731966
27fatty acid beta-oxidation (GO:0006635)3.53871023
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.52532632
29L-amino acid import (GO:0043092)3.51325422
30succinate metabolic process (GO:0006105)3.49372774
31short-chain fatty acid metabolic process (GO:0046459)3.49301897
32regulation of synapse maturation (GO:0090128)3.48660834
33regulation of neuronal synaptic plasticity (GO:0048168)3.47308437
34cell communication involved in cardiac conduction (GO:0086065)3.43002114
35regulation of fatty acid oxidation (GO:0046320)3.42643182
36regulation of voltage-gated calcium channel activity (GO:1901385)3.36307195
37quaternary ammonium group transport (GO:0015697)3.36291343
38vocalization behavior (GO:0071625)3.35654669
39positive regulation of fatty acid oxidation (GO:0046321)3.34375633
40sodium ion export (GO:0071436)3.33948840
41synaptic vesicle maturation (GO:0016188)3.27502572
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26499465
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26477850
44negative regulation of potassium ion transmembrane transport (GO:1901380)3.24666919
45locomotory exploration behavior (GO:0035641)3.23069898
46neuronal ion channel clustering (GO:0045161)3.20683465
47regulation of glutamate receptor signaling pathway (GO:1900449)3.20680679
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.20287974
49fatty acid oxidation (GO:0019395)3.17329337
50cell communication by electrical coupling (GO:0010644)3.16927832
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16880169
52valine metabolic process (GO:0006573)3.15413463
53regulation of ARF protein signal transduction (GO:0032012)3.15295443
54regulation of acyl-CoA biosynthetic process (GO:0050812)3.14601227
55neuromuscular process controlling balance (GO:0050885)3.14111348
56lipid oxidation (GO:0034440)3.13830137
57tricarboxylic acid metabolic process (GO:0072350)3.11403417
58potassium ion import (GO:0010107)3.11104550
59cellular potassium ion homeostasis (GO:0030007)3.11041050
60neurotransmitter transport (GO:0006836)3.10743743
61amino-acid betaine metabolic process (GO:0006577)3.10603840
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09149057
63neuronal action potential propagation (GO:0019227)3.08630525
64acetyl-CoA metabolic process (GO:0006084)3.07258860
65amino acid import (GO:0043090)3.07213282
66carnitine metabolic process (GO:0009437)3.06689978
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06467314
68* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05398397
69ionotropic glutamate receptor signaling pathway (GO:0035235)3.05017635
70drug catabolic process (GO:0042737)3.04963752
71regulation of membrane repolarization (GO:0060306)3.03825508
72regulation of neurotransmitter levels (GO:0001505)3.01812957
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.01032326
74ventricular cardiac muscle cell action potential (GO:0086005)3.00535391
75biotin metabolic process (GO:0006768)2.99816045
76dicarboxylic acid biosynthetic process (GO:0043650)2.98710400
77cardiac muscle contraction (GO:0060048)2.98682917
78positive regulation of dendritic spine development (GO:0060999)2.98230859
79neurotransmitter-gated ion channel clustering (GO:0072578)2.97825731
80fatty acid catabolic process (GO:0009062)2.97570523
81exploration behavior (GO:0035640)2.97103209
82exogenous drug catabolic process (GO:0042738)2.96988622
83* respiratory electron transport chain (GO:0022904)2.94859507
84sarcoplasmic reticulum calcium ion transport (GO:0070296)2.94387408
85axonemal dynein complex assembly (GO:0070286)2.93750943
86glycine transport (GO:0015816)2.93744779
87regulation of cofactor metabolic process (GO:0051193)2.93717418
88regulation of coenzyme metabolic process (GO:0051196)2.93717418
89regulation of triglyceride catabolic process (GO:0010896)2.91568894
90regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90610452
91creatine metabolic process (GO:0006600)2.88962455
92relaxation of cardiac muscle (GO:0055119)2.88444577
93cellular ketone body metabolic process (GO:0046950)2.88220968
94homocysteine metabolic process (GO:0050667)2.86257541
95* electron transport chain (GO:0022900)2.86093154
96plasma membrane repair (GO:0001778)2.83732862
97glutamate metabolic process (GO:0006536)2.81938268
98cardiac conduction (GO:0061337)2.81812962
99response to parathyroid hormone (GO:0071107)2.81499760
100membrane repolarization (GO:0086009)2.80741001
101phosphate ion transport (GO:0006817)2.80730742
102synaptic vesicle docking involved in exocytosis (GO:0016081)2.79567964
103drug transmembrane transport (GO:0006855)2.79389460
104glyoxylate metabolic process (GO:0046487)2.79386289
105sodium ion homeostasis (GO:0055078)2.79307003
106regulation of synapse structural plasticity (GO:0051823)2.79239181
107regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78372554
108positive regulation of membrane potential (GO:0045838)2.77973374
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77796243
110activation of protein kinase A activity (GO:0034199)2.77634685
111positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76646879
112dopamine receptor signaling pathway (GO:0007212)2.76616575
113monocarboxylic acid catabolic process (GO:0072329)2.76467762
114positive regulation of lipid catabolic process (GO:0050996)2.75078606
115regulation of synaptic plasticity (GO:0048167)2.73565380
116ethanol oxidation (GO:0006069)2.72594308
117postsynaptic membrane organization (GO:0001941)2.70891224
118L-phenylalanine metabolic process (GO:0006558)2.70648345
119erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.70648345
120cysteine metabolic process (GO:0006534)2.70024711
121phosphate ion transmembrane transport (GO:0035435)2.69454313
122adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.68669047
123oxaloacetate metabolic process (GO:0006107)2.68599061
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67614965
125desmosome organization (GO:0002934)2.66794477
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66566471
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.66558885
128regulation of cell communication by electrical coupling (GO:0010649)2.66235678
129regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.64410063
130intracellular lipid transport (GO:0032365)2.64190438
131regulation of heart rate by cardiac conduction (GO:0086091)2.64033438
132regulation of fatty acid beta-oxidation (GO:0031998)2.63342229
133regulation of female receptivity (GO:0045924)2.62667835
134branched-chain amino acid metabolic process (GO:0009081)2.61830320
135cardiac muscle cell action potential involved in contraction (GO:0086002)2.60927270
136protein localization to synapse (GO:0035418)2.60785709
137bundle of His cell to Purkinje myocyte communication (GO:0086069)2.60534718
138branched-chain amino acid catabolic process (GO:0009083)2.60497917
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60195242
140L-phenylalanine catabolic process (GO:0006559)2.60195242
141neurotransmitter secretion (GO:0007269)2.60096913
142gamma-aminobutyric acid signaling pathway (GO:0007214)2.59739639
143synaptic transmission, glutamatergic (GO:0035249)2.59139717
144layer formation in cerebral cortex (GO:0021819)2.58190658
145serine family amino acid catabolic process (GO:0009071)2.56772327
146myelin maintenance (GO:0043217)2.55940131
147dicarboxylic acid catabolic process (GO:0043649)2.54574551
148triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53933134
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.53228579
150response to mercury ion (GO:0046689)2.52928282
151regulation of neurotransmitter secretion (GO:0046928)2.52625220
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52066238
153cerebellar Purkinje cell layer development (GO:0021680)2.51366942
154auditory behavior (GO:0031223)2.49073773
155detection of calcium ion (GO:0005513)2.48911061
156negative regulation of inclusion body assembly (GO:0090084)2.48852745
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.48700174
158neurotransmitter catabolic process (GO:0042135)2.47399057
159positive regulation of sodium ion transport (GO:0010765)2.47120819
160motile cilium assembly (GO:0044458)2.46301462
161regulation of vesicle fusion (GO:0031338)2.46051132
162membrane depolarization during action potential (GO:0086010)2.45316127
163regulation of sodium ion transmembrane transport (GO:1902305)2.43888834
164gamma-aminobutyric acid transport (GO:0015812)2.42561619
165dendritic spine morphogenesis (GO:0060997)2.42448007
166ethanol metabolic process (GO:0006067)2.42181628
167regulation of sodium ion transmembrane transporter activity (GO:2000649)2.40886376
168mating behavior (GO:0007617)2.38174683
169negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34872436
170cellular response to monoamine stimulus (GO:0071868)2.34851789
171cellular response to catecholamine stimulus (GO:0071870)2.34851789
172cGMP-mediated signaling (GO:0019934)2.34586158
173long-term memory (GO:0007616)2.33678974
174regulation of glycogen (starch) synthase activity (GO:2000465)2.32543236
175cell migration in hindbrain (GO:0021535)2.32205791
176cell-cell junction maintenance (GO:0045217)2.31896090
177synaptic vesicle endocytosis (GO:0048488)2.31706405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.49879943
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.00646882
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.87346087
4EZH2_22144423_ChIP-Seq_EOC_Human2.73728191
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48697968
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.47000094
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.40268496
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37304158
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21782188
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06435161
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02979472
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00181315
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97290568
14ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88278555
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88186722
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88186722
17DROSHA_22980978_ChIP-Seq_HELA_Human1.83275830
18ZNF263_19887448_ChIP-Seq_K562_Human1.82518384
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81799336
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80481478
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79592278
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79209710
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77707967
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75929373
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.70231873
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66592212
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62455223
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.60226897
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.59258992
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58975164
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56446536
32SMC4_20622854_ChIP-Seq_HELA_Human1.56249304
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.51733721
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.51270167
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50781867
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48717509
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.48454090
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44422862
39P68_20966046_ChIP-Seq_HELA_Human1.43414750
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.42128725
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40990876
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40496418
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38309091
44RACK7_27058665_Chip-Seq_MCF-7_Human1.35271052
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34177096
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33530972
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33201241
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32786271
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32718116
50KDM2B_26808549_Chip-Seq_DND41_Human1.32463196
51CREB1_26743006_Chip-Seq_LNCaP_Human1.31886027
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.31467723
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.31467723
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.28835744
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28459930
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.26717069
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26320946
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.25898654
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.23134099
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.22651372
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22563353
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19815182
63REST_21632747_ChIP-Seq_MESCs_Mouse1.19155134
64GATA1_22025678_ChIP-Seq_K562_Human1.18426577
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18243286
66SA1_27219007_Chip-Seq_Bcells_Human1.15880174
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.14966499
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13282202
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.13064968
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12135960
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10723095
72OCT4_19829295_ChIP-Seq_ESCs_Human1.10605256
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.10093827
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08434948
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.07766142
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07397238
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.07394777
78STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06542462
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05527431
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05526162
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04938354
82RXR_22108803_ChIP-Seq_LS180_Human1.04900997
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03348208
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.02937932
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02558779
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.02452252
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.02028365
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01098982
89RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01078386
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.00981052
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99077923
92CTCF_27219007_Chip-Seq_Bcells_Human0.98357907
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98327808
94KDM2B_26808549_Chip-Seq_K562_Human0.97286688
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96409243
96TP63_22573176_ChIP-Seq_HFKS_Human0.95901871
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95102195
98EGR1_19032775_ChIP-ChIP_M12_Human0.95028293
99TCF7_22412390_ChIP-Seq_EML_Mouse0.93461051
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93427093
101CTCF_20526341_ChIP-Seq_ESCs_Human0.93280146
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92566437
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90451845
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.90161017
105BCAT_22108803_ChIP-Seq_LS180_Human0.89808732
106GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87911799
107NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87906002
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.87703790
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87398341
110LXR_22292898_ChIP-Seq_THP-1_Human0.86964285
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85548556
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.84755569
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84449479
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.83554572
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.82511116
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82165313
117AR_21572438_ChIP-Seq_LNCaP_Human0.81596084
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81487433
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81307420
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80741701
121SMAD4_21799915_ChIP-Seq_A2780_Human0.80537206
122AR_25329375_ChIP-Seq_VCAP_Human0.80524616
123KLF4_19829295_ChIP-Seq_ESCs_Human0.79306650
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78390023
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78229443
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.77603328
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76931413
128ZNF274_21170338_ChIP-Seq_K562_Hela0.75919072
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75467905
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74904395
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74902282
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74492687
133CLOCK_20551151_ChIP-Seq_293T_Human0.73929499
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.73762824
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73422108
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73275664
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.71986910
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.71445880
139TCF4_22108803_ChIP-Seq_LS180_Human0.71334529
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.70813851
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69970204
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69970204
143OCT1_27270436_Chip-Seq_PROSTATE_Human0.69705831
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69589027
145AR_19668381_ChIP-Seq_PC3_Human0.68849672
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.68444122
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.68159571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.99766405
2MP0003646_muscle_fatigue3.81312247
3MP0003880_abnormal_central_pattern3.67487223
4MP0005423_abnormal_somatic_nervous3.57263202
5MP0005360_urolithiasis3.46014985
6MP0002822_catalepsy3.41369894
7MP0004859_abnormal_synaptic_plasticity3.33174433
8MP0005085_abnormal_gallbladder_physiolo3.04604481
9MP0002139_abnormal_hepatobiliary_system2.97103644
10MP0004130_abnormal_muscle_cell2.88684239
11MP0003195_calcinosis2.86792316
12MP0000751_myopathy2.84498365
13MP0009379_abnormal_foot_pigmentation2.79016758
14MP0004215_abnormal_myocardial_fiber2.70130359
15MP0002837_dystrophic_cardiac_calcinosis2.67717169
16MP0003329_amyloid_beta_deposits2.51248330
17MP0004084_abnormal_cardiac_muscle2.40557881
18MP0005365_abnormal_bile_salt2.33828725
19MP0002734_abnormal_mechanical_nocicepti2.30965288
20MP0010234_abnormal_vibrissa_follicle2.22381125
21MP0006036_abnormal_mitochondrial_physio2.19470995
22MP0002572_abnormal_emotion/affect_behav2.15530641
23MP0005330_cardiomyopathy2.10531242
24MP0005332_abnormal_amino_acid2.10202455
25MP0004036_abnormal_muscle_relaxation2.05490020
26MP0003252_abnormal_bile_duct2.03921619
27MP0008875_abnormal_xenobiotic_pharmacok1.98420189
28MP0005535_abnormal_body_temperature1.88354275
29MP0004484_altered_response_of1.86022814
30MP0003123_paternal_imprinting1.82846154
31MP0008775_abnormal_heart_ventricle1.79721223
32MP0004145_abnormal_muscle_electrophysio1.79621119
33MP0001970_abnormal_pain_threshold1.78600791
34MP0005666_abnormal_adipose_tissue1.75377116
35MP0008961_abnormal_basal_metabolism1.73507079
36MP0001968_abnormal_touch/_nociception1.72142974
37MP0002733_abnormal_thermal_nociception1.69626405
38MP0009046_muscle_twitch1.68818223
39MP0004019_abnormal_vitamin_homeostasis1.67959860
40MP0003635_abnormal_synaptic_transmissio1.67905312
41MP0001502_abnormal_circadian_rhythm1.66786872
42MP0005670_abnormal_white_adipose1.66501157
43MP0010329_abnormal_lipoprotein_level1.65441852
44MP0005409_darkened_coat_color1.63036727
45MP0005620_abnormal_muscle_contractility1.61873711
46MP0004087_abnormal_muscle_fiber1.60009031
47MP0000749_muscle_degeneration1.59087034
48MP0000566_synostosis1.58817751
49MP0002909_abnormal_adrenal_gland1.58474637
50MP0001765_abnormal_ion_homeostasis1.57636194
51MP0002972_abnormal_cardiac_muscle1.55260933
52MP0004185_abnormal_adipocyte_glucose1.51573083
53MP0002971_abnormal_brown_adipose1.51406090
54MP0002735_abnormal_chemical_nociception1.48086281
55MP0000920_abnormal_myelination1.45957316
56MP0005584_abnormal_enzyme/coenzyme_acti1.41531051
57MP0002118_abnormal_lipid_homeostasis1.37782591
58MP0002557_abnormal_social/conspecific_i1.36528148
59MP0009745_abnormal_behavioral_response1.33049179
60MP0002249_abnormal_larynx_morphology1.32687234
61MP0002067_abnormal_sensory_capabilities1.31828969
62MP0003137_abnormal_impulse_conducting1.31486849
63MP0009643_abnormal_urine_homeostasis1.31325007
64MP0002066_abnormal_motor_capabilities/c1.31072243
65MP0002138_abnormal_hepatobiliary_system1.28725041
66MP0000747_muscle_weakness1.27584601
67MP0005167_abnormal_blood-brain_barrier1.26872902
68MP0001756_abnormal_urination1.26422453
69MP0001501_abnormal_sleep_pattern1.25456305
70MP0004742_abnormal_vestibular_system1.23926911
71MP0005646_abnormal_pituitary_gland1.23731939
72MP0000750_abnormal_muscle_regeneration1.22946514
73MP0002796_impaired_skin_barrier1.22730405
74MP0001544_abnormal_cardiovascular_syste1.22405479
75MP0005385_cardiovascular_system_phenoty1.22405479
76MP0002106_abnormal_muscle_physiology1.22315668
77MP0002653_abnormal_ependyma_morphology1.20384863
78MP0002332_abnormal_exercise_endurance1.18671810
79MP0001485_abnormal_pinna_reflex1.17252874
80MP0002063_abnormal_learning/memory/cond1.14703696
81MP0000013_abnormal_adipose_tissue1.13809457
82MP0003631_nervous_system_phenotype1.13307282
83MP0005636_abnormal_mineral_homeostasis1.13003664
84MP0005451_abnormal_body_composition1.12940556
85MP0005375_adipose_tissue_phenotype1.12858210
86MP0004085_abnormal_heartbeat1.12690611
87MP0004510_myositis1.12428826
88MP0000230_abnormal_systemic_arterial1.11668899
89MP0000604_amyloidosis1.10923012
90MP0000955_abnormal_spinal_cord1.09952763
91MP0002269_muscular_atrophy1.09375320
92MP0002882_abnormal_neuron_morphology1.09239497
93MP0004811_abnormal_neuron_physiology1.08569660
94MP0008569_lethality_at_weaning1.08429244
95MP0005319_abnormal_enzyme/_coenzyme1.08179368
96MP0006138_congestive_heart_failure1.08149390
97MP0003075_altered_response_to1.07249638
98MP0002064_seizures1.06807429
99MP0004270_analgesia1.06270529
100MP0001666_abnormal_nutrient_absorption1.05191018
101MP0003634_abnormal_glial_cell1.04830049
102MP0002736_abnormal_nociception_after1.04301164
103MP0003879_abnormal_hair_cell1.04084490
104MP0009780_abnormal_chondrocyte_physiolo1.03400636
105MP0001346_abnormal_lacrimal_gland1.03393781
106MP0001905_abnormal_dopamine_level1.02767468
107MP0005083_abnormal_biliary_tract1.01433490
108MP0005369_muscle_phenotype1.00769114
109MP0002078_abnormal_glucose_homeostasis1.00503919
110MP0003787_abnormal_imprinting1.00460427
111MP0005187_abnormal_penis_morphology0.98882777
112MP0003705_abnormal_hypodermis_morpholog0.97808958
113MP0001486_abnormal_startle_reflex0.95221264
114MP0006276_abnormal_autonomic_nervous0.94712813
115MP0001963_abnormal_hearing_physiology0.94614070
116MP0000678_abnormal_parathyroid_gland0.94012913
117MP0010630_abnormal_cardiac_muscle0.93566787
118MP0000778_abnormal_nervous_system0.93420322
119MP0006035_abnormal_mitochondrial_morpho0.90972074
120MP0000759_abnormal_skeletal_muscle0.90795156
121MP0002229_neurodegeneration0.88149538
122MP0003122_maternal_imprinting0.87972365
123MP0004885_abnormal_endolymph0.86673634
124MP0002272_abnormal_nervous_system0.86623301
125MP0003633_abnormal_nervous_system0.86154959
126MP0005165_increased_susceptibility_to0.85541686
127MP0000609_abnormal_liver_physiology0.84416640
128MP0008872_abnormal_physiological_respon0.83779703
129MP0002638_abnormal_pupillary_reflex0.83707148
130MP0005377_hearing/vestibular/ear_phenot0.81846473
131MP0003878_abnormal_ear_physiology0.81846473
132MP0003191_abnormal_cellular_cholesterol0.81059428
133MP0002089_abnormal_postnatal_growth/wei0.80220716
134MP0008874_decreased_physiological_sensi0.79973358
135MP0002152_abnormal_brain_morphology0.79917174
136MP0003690_abnormal_glial_cell0.79556430
137MP0003300_gastrointestinal_ulcer0.79291326
138MP0001440_abnormal_grooming_behavior0.78768407
139MP0001984_abnormal_olfaction0.78381891
140MP0003632_abnormal_nervous_system0.78120727
141MP0003221_abnormal_cardiomyocyte_apopto0.75350432
142MP0003638_abnormal_response/metabolism_0.75128618
143MP0000026_abnormal_inner_ear0.73935668
144MP0003183_abnormal_peptide_metabolism0.73099954
145MP0005386_behavior/neurological_phenoty0.72916821
146MP0004924_abnormal_behavior0.72916821
147MP0003938_abnormal_ear_development0.71381484
148MP0005448_abnormal_energy_balance0.71271932
149MP0005166_decreased_susceptibility_to0.70349968
150MP0002136_abnormal_kidney_physiology0.68232037
151MP0002876_abnormal_thyroid_physiology0.67663339
152MP0005503_abnormal_tendon_morphology0.64396334
153MP0002184_abnormal_innervation0.63155420

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.33831934
2Obstructive sleep apnea (HP:0002870)4.32517191
3Hyperglycinuria (HP:0003108)4.27464178
4Gout (HP:0001997)4.22947693
5Ventricular fibrillation (HP:0001663)4.22613117
6Bundle branch block (HP:0011710)4.21046206
7Myoglobinuria (HP:0002913)4.13873105
8Abnormality of binocular vision (HP:0011514)4.08700098
9Diplopia (HP:0000651)4.08700098
10Neurofibrillary tangles (HP:0002185)3.88759994
11Sudden death (HP:0001699)3.81907710
12Increased circulating renin level (HP:0000848)3.81226772
13Supranuclear gaze palsy (HP:0000605)3.78063226
14Exercise-induced muscle cramps (HP:0003710)3.72954865
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.68937996
16Ketoacidosis (HP:0001993)3.68713596
17Epileptic encephalopathy (HP:0200134)3.61987150
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.56907876
19Absent/shortened dynein arms (HP:0200106)3.56907876
20Hypoglycemic coma (HP:0001325)3.53609617
21Abnormality of glycine metabolism (HP:0010895)3.52668595
22Abnormality of serine family amino acid metabolism (HP:0010894)3.52668595
23Ankle clonus (HP:0011448)3.50230935
24Ketosis (HP:0001946)3.48417334
25Myokymia (HP:0002411)3.46809610
26Hypokalemic alkalosis (HP:0001949)3.44569382
27Abnormal ciliary motility (HP:0012262)3.42577209
28Abnormal respiratory motile cilium physiology (HP:0012261)3.40789971
29Abnormal respiratory motile cilium morphology (HP:0005938)3.37023028
30Abnormal respiratory epithelium morphology (HP:0012253)3.37023028
31Metabolic alkalosis (HP:0200114)3.35856621
32Hyperglycinemia (HP:0002154)3.31416119
33Heart block (HP:0012722)3.29115481
34Febrile seizures (HP:0002373)3.22843875
35Hyperammonemia (HP:0001987)3.21392997
36Abnormality of fatty-acid metabolism (HP:0004359)3.18731422
37Right ventricular cardiomyopathy (HP:0011663)3.17005694
38Focal motor seizures (HP:0011153)3.09190736
39Hyperuricemia (HP:0002149)3.05457559
40Increased purine levels (HP:0004368)3.05457559
41Abnormal atrioventricular conduction (HP:0005150)3.05359247
42Cerebral inclusion bodies (HP:0100314)3.04412755
43Calf muscle hypertrophy (HP:0008981)3.03088722
44Abnormal eating behavior (HP:0100738)3.02723696
45Atrioventricular block (HP:0001678)3.00445114
46Atonic seizures (HP:0010819)3.00409888
47Ventricular tachycardia (HP:0004756)3.00144138
48Syncope (HP:0001279)2.90101804
49Atrial fibrillation (HP:0005110)2.89522445
50Hyperactive renin-angiotensin system (HP:0000841)2.84878054
51Papilledema (HP:0001085)2.84755417
52Dicarboxylic aciduria (HP:0003215)2.81431579
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.81431579
54Annular pancreas (HP:0001734)2.79677007
55Muscle hypertrophy of the lower extremities (HP:0008968)2.79583492
56Ventricular arrhythmia (HP:0004308)2.77009100
57Torticollis (HP:0000473)2.77002253
58Abnormality of chloride homeostasis (HP:0011422)2.75594943
59Xanthomatosis (HP:0000991)2.72185921
60Primary atrial arrhythmia (HP:0001692)2.70527706
61Muscle fiber splitting (HP:0003555)2.69247237
62Sleep apnea (HP:0010535)2.68054760
63Rhabdomyolysis (HP:0003201)2.67365644
64Abnormality of purine metabolism (HP:0004352)2.65082916
65Hyporeflexia of lower limbs (HP:0002600)2.65020835
66Rhinitis (HP:0012384)2.64308106
67Prolonged QT interval (HP:0001657)2.63291802
68Nasal polyposis (HP:0100582)2.61173292
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57649714
70Generalized aminoaciduria (HP:0002909)2.55743628
71Hyperaldosteronism (HP:0000859)2.54868649
72Absence seizures (HP:0002121)2.53882438
73Difficulty running (HP:0009046)2.53642782
74Abnormality of renin-angiotensin system (HP:0000847)2.53230729
75Postural instability (HP:0002172)2.52938320
76Supraventricular tachycardia (HP:0004755)2.52874416
77Peripheral hypomyelination (HP:0007182)2.49159257
78Foot dorsiflexor weakness (HP:0009027)2.47643778
79Action tremor (HP:0002345)2.46763572
80Supraventricular arrhythmia (HP:0005115)2.45168639
81Proximal tubulopathy (HP:0000114)2.44201533
82Palpitations (HP:0001962)2.43834519
83Abnormality of the nasal mucosa (HP:0000433)2.43508501
84Neonatal onset (HP:0003623)2.42817959
85Alkalosis (HP:0001948)2.41781007
86Muscle stiffness (HP:0003552)2.39612988
87Limb dystonia (HP:0002451)2.37752278
88Systemic lupus erythematosus (HP:0002725)2.36574552
89Focal dystonia (HP:0004373)2.36188265
90Renal salt wasting (HP:0000127)2.34795890
91Abnormality of the calf musculature (HP:0001430)2.34240076
92Abnormality of the foot musculature (HP:0001436)2.33215998
93Hypercortisolism (HP:0001578)2.31912697
94Hypomagnesemia (HP:0002917)2.31056192
95Asymmetric septal hypertrophy (HP:0001670)2.30046441
96Polyuria (HP:0000103)2.29889270
97Abnormal urine output (HP:0012590)2.27887655
98Metabolic acidosis (HP:0001942)2.26968584
99Chronic bronchitis (HP:0004469)2.26946938
100Dysmetric saccades (HP:0000641)2.26791735
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26485651
102Depression (HP:0000716)2.25458688
103Abnormal EKG (HP:0003115)2.24784734
104Cerebral edema (HP:0002181)2.23733483
105Craniofacial dystonia (HP:0012179)2.23372117
106Bronchomalacia (HP:0002780)2.23261320
107Akinesia (HP:0002304)2.20421024
108Distal lower limb muscle weakness (HP:0009053)2.19296352
109Hypoalphalipoproteinemia (HP:0003233)2.18351195
110Abnormality of serum amino acid levels (HP:0003112)2.18284638
111Conjunctival hamartoma (HP:0100780)2.17487761
112Neuronal loss in central nervous system (HP:0002529)2.17384958
113Hyperkalemia (HP:0002153)2.15342904
114Truncus arteriosus (HP:0001660)2.15156132
115Status epilepticus (HP:0002133)2.13492893
116Spastic gait (HP:0002064)2.13166030
117Dysmetria (HP:0001310)2.13136105
118Epidermoid cyst (HP:0200040)2.13096737
119Abnormality of renal excretion (HP:0011036)2.12900996
120Progressive cerebellar ataxia (HP:0002073)2.11721968
121Lethargy (HP:0001254)2.11703977
122Nausea (HP:0002018)2.11692122
123Rigidity (HP:0002063)2.10970506
124Hyperlipoproteinemia (HP:0010980)2.10828045
125Abnormality of complement system (HP:0005339)2.10752516
126Abnormality of potassium homeostasis (HP:0011042)2.10163004
127Atelectasis (HP:0100750)2.09413792
128Visual hallucinations (HP:0002367)2.09251407
129Abnormality of magnesium homeostasis (HP:0004921)2.08726428
130Adrenal overactivity (HP:0002717)2.04846492
131Hyperthyroidism (HP:0000836)2.03657345
132Hyperparathyroidism (HP:0000843)2.03230908
133Dialeptic seizures (HP:0011146)2.03029995
134Central scotoma (HP:0000603)2.02356241
135Deep venous thrombosis (HP:0002625)2.00078387
136Hypokalemia (HP:0002900)1.99680275
137Vomiting (HP:0002013)1.97772474
138Generalized tonic-clonic seizures (HP:0002069)1.97751337
139Dysdiadochokinesis (HP:0002075)1.95111248
140Axonal loss (HP:0003447)1.94817804
141Hemiplegia (HP:0002301)1.93751777
142Intention tremor (HP:0002080)1.93461098
143Neonatal death (HP:0003811)1.93441976
144Tetraplegia (HP:0002445)1.93269981
145Truncal ataxia (HP:0002078)1.92503580
146Anxiety (HP:0000739)1.91168026
147Myotonia (HP:0002486)1.91158330
148Subaortic stenosis (HP:0001682)1.90119653
149Abnormality of the left ventricular outflow tract (HP:0011103)1.90119653
150Delayed CNS myelination (HP:0002188)1.89913256
151Turricephaly (HP:0000262)1.89682713
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89098195
153Lipoatrophy (HP:0100578)1.88964603
154Focal seizures (HP:0007359)1.88795711
155Dilated cardiomyopathy (HP:0001644)1.85585782
156Glomerulonephritis (HP:0000099)1.84820663
157Intrahepatic cholestasis (HP:0001406)1.84447911
158Complement deficiency (HP:0004431)1.84202230
159Growth hormone excess (HP:0000845)1.84201723
160Hepatic necrosis (HP:0002605)1.84091128
161Rapidly progressive (HP:0003678)1.80630987
162Mutism (HP:0002300)1.79922541
163Cerebral hypomyelination (HP:0006808)1.79114413
164EMG: neuropathic changes (HP:0003445)1.79027762
165Stereotypic behavior (HP:0000733)1.76846379
166Infertility (HP:0000789)1.74330475
167Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72608363
168Decreased circulating renin level (HP:0003351)1.72031297
169Bradykinesia (HP:0002067)1.71722734
170Urinary bladder sphincter dysfunction (HP:0002839)1.71563030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.18428883
2TRIB32.98581694
3PDK32.97846369
4PDK42.97846369
5MAPK152.82868251
6EPHA42.82261395
7NEK12.80604274
8WNK42.79193015
9DAPK22.54421108
10LMTK22.40250305
11UHMK12.38709826
12MARK12.38449655
13STK382.33014536
14PRPF4B2.19295646
15TTN2.14138202
16WNK32.07527669
17BCKDK2.06903300
18PRKD32.03095196
19PHKG11.99012144
20PHKG21.99012144
21OXSR11.98634674
22CAMKK11.93097063
23MAP3K91.93057901
24PDK21.89060853
25KSR21.88281611
26NTRK31.87311634
27OBSCN1.76580465
28SIK21.69707950
29PKN21.62343504
30RIPK41.59624759
31MAP2K41.58620164
32MARK21.55278091
33RIPK11.43403701
34STK391.38521984
35ARAF1.37533340
36MAP3K111.32745401
37MST1R1.31866531
38PAK61.30672861
39TAOK11.27588672
40MAP3K21.21383538
41SIK11.17505639
42ICK1.16215947
43WNK11.15085230
44SMG11.09272003
45MAP3K71.05889504
46MAP3K41.03637397
47CAMK2B1.02399208
48MINK10.99891686
49MAP3K130.99284285
50CAMK10.98286521
51INSRR0.98089041
52CAMKK20.96340425
53PRKCH0.94690624
54PDK10.91299842
55SGK30.91119346
56STK240.90983676
57DMPK0.87996478
58ERN10.86229105
59PDPK10.85440041
60CAMK2G0.83015451
61PRKAA20.82533862
62SGK20.81606685
63SGK4940.80560410
64SGK2230.80560410
65MAP2K70.79962168
66PRKAA10.79369551
67FRK0.78843007
68MAP3K10.78037871
69MUSK0.77699877
70TESK10.77616737
71DYRK1A0.75807933
72STK110.75544040
73TIE10.75525506
74TNK20.73636600
75CDK150.73059846
76ALK0.72224150
77CDK11A0.71205220
78MAPK100.71031207
79PTK60.70733026
80LRRK20.69927392
81JAK20.69811466
82PIK3CG0.66508662
83PRKD10.66012235
84CDK50.65655187
85CAMK40.65241908
86PKN10.64095368
87RET0.63830826
88GRK50.62643330
89SGK10.62411783
90CDK140.62350980
91HIPK20.61596550
92PAK30.61513823
93CDK180.61440296
94CAMK1D0.60455379
95MAPKAPK50.59670027
96PRKCG0.59191630
97NTRK10.58851119
98NEK60.58683463
99CAMK2D0.57935563
100PNCK0.57864467
101PRKACG0.57301163
102CAMK2A0.56987173
103FER0.56486749
104MAPK40.56409699
105JAK10.56265358
106STK38L0.55758144
107PRKG20.55511527
108MAP2K20.54497264
109PIK3CA0.54210987
110PRKCZ0.53512685
111MAPK120.52786026
112MAP2K60.52502396
113ERBB20.51670200
114MAP2K30.51108071
115CDK190.49808871
116TYRO30.49536836
117EEF2K0.48017768
118CDC42BPA0.47568225
119FGFR40.46597092
120MAP2K10.45689643
121RPS6KA30.45572783
122NTRK20.45561913
123DYRK1B0.44677340
124BRAF0.44647068
125MAP3K30.43874689
126TAOK20.43163436
127MAPK70.43006248
128BMX0.41595455
129CASK0.41407640
130DAPK30.40935648
131MAPKAPK30.40631268
132MAPK110.40322315
133MAPK130.40184122
134DAPK10.39626914
135LATS20.38334245
136PRKACA0.38008134
137ABL20.35632503
138CAMK1G0.35559777
139PDGFRA0.33827488

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.48931967
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.23254512
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08598914
4Propanoate metabolism_Homo sapiens_hsa006403.06962052
5Fatty acid degradation_Homo sapiens_hsa000712.68438132
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.60980004
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38437303
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29738839
9Arginine biosynthesis_Homo sapiens_hsa002202.16412369
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15169334
11Butanoate metabolism_Homo sapiens_hsa006502.07561066
12Fatty acid metabolism_Homo sapiens_hsa012122.06300145
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.80156589
14PPAR signaling pathway_Homo sapiens_hsa033201.78808173
15Carbon metabolism_Homo sapiens_hsa012001.67009181
16beta-Alanine metabolism_Homo sapiens_hsa004101.62793208
17Tryptophan metabolism_Homo sapiens_hsa003801.51590527
18Cardiac muscle contraction_Homo sapiens_hsa042601.51429890
19Olfactory transduction_Homo sapiens_hsa047401.50788693
20Prion diseases_Homo sapiens_hsa050201.43447479
21Bile secretion_Homo sapiens_hsa049761.42917980
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42590812
23Pyruvate metabolism_Homo sapiens_hsa006201.37710555
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37411937
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24652172
26Gastric acid secretion_Homo sapiens_hsa049711.17540899
27Fatty acid biosynthesis_Homo sapiens_hsa000611.15710404
28Peroxisome_Homo sapiens_hsa041461.12665844
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09486185
30Synaptic vesicle cycle_Homo sapiens_hsa047211.08834990
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06403458
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05303365
33Estrogen signaling pathway_Homo sapiens_hsa049151.04140782
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01894831
35Phenylalanine metabolism_Homo sapiens_hsa003601.00184894
36Insulin secretion_Homo sapiens_hsa049110.95727302
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95367711
38Adipocytokine signaling pathway_Homo sapiens_hsa049200.94726088
39GABAergic synapse_Homo sapiens_hsa047270.94297577
40Starch and sucrose metabolism_Homo sapiens_hsa005000.93990207
41Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93930060
42Dilated cardiomyopathy_Homo sapiens_hsa054140.93778656
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92417155
44Circadian entrainment_Homo sapiens_hsa047130.90234171
45Salivary secretion_Homo sapiens_hsa049700.90014787
46Glucagon signaling pathway_Homo sapiens_hsa049220.89910237
47Biosynthesis of amino acids_Homo sapiens_hsa012300.89872969
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88228702
49Serotonergic synapse_Homo sapiens_hsa047260.87550219
50Insulin resistance_Homo sapiens_hsa049310.86611050
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86494220
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.86124680
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86071411
54VEGF signaling pathway_Homo sapiens_hsa043700.85402528
55Amphetamine addiction_Homo sapiens_hsa050310.85184414
56Morphine addiction_Homo sapiens_hsa050320.84529147
57Melanogenesis_Homo sapiens_hsa049160.83477463
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.82682520
59Glutamatergic synapse_Homo sapiens_hsa047240.82093891
60Long-term potentiation_Homo sapiens_hsa047200.80938256
61Glycerolipid metabolism_Homo sapiens_hsa005610.80590459
62Gap junction_Homo sapiens_hsa045400.79888738
63Calcium signaling pathway_Homo sapiens_hsa040200.79722919
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77553104
65Nicotine addiction_Homo sapiens_hsa050330.76102223
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75786076
67Chemical carcinogenesis_Homo sapiens_hsa052040.75080425
68Type II diabetes mellitus_Homo sapiens_hsa049300.74713761
69Long-term depression_Homo sapiens_hsa047300.72044876
70Oxytocin signaling pathway_Homo sapiens_hsa049210.71908301
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70869666
72Cholinergic synapse_Homo sapiens_hsa047250.70209401
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70063263
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69598097
75ErbB signaling pathway_Homo sapiens_hsa040120.69150050
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68649174
77Mineral absorption_Homo sapiens_hsa049780.68507629
78Complement and coagulation cascades_Homo sapiens_hsa046100.68153658
79Glioma_Homo sapiens_hsa052140.67320374
80Parkinsons disease_Homo sapiens_hsa050120.67184397
81cAMP signaling pathway_Homo sapiens_hsa040240.66738971
82Renin secretion_Homo sapiens_hsa049240.64001511
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63305268
84Notch signaling pathway_Homo sapiens_hsa043300.63167264
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62697785
86Choline metabolism in cancer_Homo sapiens_hsa052310.62156584
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61484444
88Oxidative phosphorylation_Homo sapiens_hsa001900.60858202
89Pancreatic secretion_Homo sapiens_hsa049720.60724655
90Caffeine metabolism_Homo sapiens_hsa002320.60616045
91Dopaminergic synapse_Homo sapiens_hsa047280.58761928
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.58020529
93Fatty acid elongation_Homo sapiens_hsa000620.57091145
94Fat digestion and absorption_Homo sapiens_hsa049750.55056267
95Thyroid hormone synthesis_Homo sapiens_hsa049180.54833989
96Alzheimers disease_Homo sapiens_hsa050100.54823495
97ABC transporters_Homo sapiens_hsa020100.54091800
98Insulin signaling pathway_Homo sapiens_hsa049100.52163933
99Lysine degradation_Homo sapiens_hsa003100.50463673
100MAPK signaling pathway_Homo sapiens_hsa040100.50145580
101Taste transduction_Homo sapiens_hsa047420.49499782
102GnRH signaling pathway_Homo sapiens_hsa049120.49277098
103AMPK signaling pathway_Homo sapiens_hsa041520.47984158
104Retinol metabolism_Homo sapiens_hsa008300.47961668
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47883637
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47668016
107Histidine metabolism_Homo sapiens_hsa003400.47502242
108Cocaine addiction_Homo sapiens_hsa050300.47156618
109Vitamin digestion and absorption_Homo sapiens_hsa049770.46754595
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45761689
111Collecting duct acid secretion_Homo sapiens_hsa049660.45416644
112Tyrosine metabolism_Homo sapiens_hsa003500.44344775
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43504737
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42393509
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.41442837
116Ras signaling pathway_Homo sapiens_hsa040140.40358488
117Arginine and proline metabolism_Homo sapiens_hsa003300.39666250
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39148678
119Ovarian steroidogenesis_Homo sapiens_hsa049130.39051061
120Axon guidance_Homo sapiens_hsa043600.38937412
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38711155
122Huntingtons disease_Homo sapiens_hsa050160.37897999
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.37728319
124Dorso-ventral axis formation_Homo sapiens_hsa043200.37173331
125Endocytosis_Homo sapiens_hsa041440.36985004
126Rap1 signaling pathway_Homo sapiens_hsa040150.34565209
127Linoleic acid metabolism_Homo sapiens_hsa005910.34385645
128Vitamin B6 metabolism_Homo sapiens_hsa007500.33474726
129Circadian rhythm_Homo sapiens_hsa047100.33373536
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33148268
131Vibrio cholerae infection_Homo sapiens_hsa051100.32495230
132Sulfur metabolism_Homo sapiens_hsa009200.31540395

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