MT-ND4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83954160
2lysine catabolic process (GO:0006554)4.63202437
3lysine metabolic process (GO:0006553)4.63202437
4positive regulation of synapse maturation (GO:0090129)4.50465028
5glutamate secretion (GO:0014047)4.33195656
6oxidative phosphorylation (GO:0006119)4.32170967
7aspartate family amino acid catabolic process (GO:0009068)4.25560884
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.21210342
9carnitine shuttle (GO:0006853)4.20827740
10synaptic vesicle exocytosis (GO:0016079)4.18668335
11tricarboxylic acid cycle (GO:0006099)4.11841354
12fatty acid transmembrane transport (GO:1902001)3.97440505
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94017643
14ATP synthesis coupled proton transport (GO:0015986)3.94017643
15potassium ion homeostasis (GO:0055075)3.90977264
162-oxoglutarate metabolic process (GO:0006103)3.77480011
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.76059633
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72662766
19cerebellar granule cell differentiation (GO:0021707)3.72353447
20regulation of synaptic vesicle exocytosis (GO:2000300)3.66410999
21regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.64270580
22neurotransmitter-gated ion channel clustering (GO:0072578)3.60330072
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.58201666
24neurotransmitter secretion (GO:0007269)3.57660063
25regulation of synapse maturation (GO:0090128)3.56799598
26cellular sodium ion homeostasis (GO:0006883)3.54456521
27fatty acid beta-oxidation (GO:0006635)3.54001939
28negative regulation of potassium ion transmembrane transport (GO:1901380)3.51104937
29positive regulation of dendritic spine morphogenesis (GO:0061003)3.48494705
30short-chain fatty acid metabolic process (GO:0046459)3.48340816
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.46364011
32L-phenylalanine catabolic process (GO:0006559)3.46364011
33amino-acid betaine transport (GO:0015838)3.45403157
34carnitine transport (GO:0015879)3.45403157
35auditory behavior (GO:0031223)3.41749934
36carnitine transmembrane transport (GO:1902603)3.39504375
37central nervous system myelination (GO:0022010)3.39305224
38axon ensheathment in central nervous system (GO:0032291)3.39305224
39succinate metabolic process (GO:0006105)3.38510766
40NADH metabolic process (GO:0006734)3.38052805
41neurotransmitter catabolic process (GO:0042135)3.35800421
42acetyl-CoA metabolic process (GO:0006084)3.34493156
43regulation of acyl-CoA biosynthetic process (GO:0050812)3.31765016
44cell communication by electrical coupling (GO:0010644)3.27547716
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.27224779
46cell communication involved in cardiac conduction (GO:0086065)3.25996748
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25055196
48L-phenylalanine metabolic process (GO:0006558)3.25055196
49cellular ketone body metabolic process (GO:0046950)3.19305693
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18997250
51dicarboxylic acid biosynthetic process (GO:0043650)3.17344389
52positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.16183604
53ATP biosynthetic process (GO:0006754)3.15748295
54fatty acid oxidation (GO:0019395)3.15183065
55vocalization behavior (GO:0071625)3.14246970
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13630594
57fatty acid catabolic process (GO:0009062)3.13346320
58lipid oxidation (GO:0034440)3.12070783
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11442015
60regulation of synaptic vesicle transport (GO:1902803)3.10374398
61dicarboxylic acid catabolic process (GO:0043649)3.09499876
62tricarboxylic acid metabolic process (GO:0072350)3.08047742
63neurotransmitter transport (GO:0006836)3.07794681
64glyoxylate metabolic process (GO:0046487)3.07606448
65aerobic respiration (GO:0009060)3.07221271
66biotin metabolic process (GO:0006768)3.07084464
67cardiac muscle contraction (GO:0060048)3.05032396
68regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03032624
69quaternary ammonium group transport (GO:0015697)3.02345393
70regulation of membrane repolarization (GO:0060306)3.02184693
71glutamate metabolic process (GO:0006536)3.00664781
72regulation of neurotransmitter levels (GO:0001505)2.99515746
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98988909
74regulation of coenzyme metabolic process (GO:0051196)2.98928607
75regulation of cofactor metabolic process (GO:0051193)2.98928607
76potassium ion import (GO:0010107)2.97890645
77cardiac myofibril assembly (GO:0055003)2.97620151
78alpha-linolenic acid metabolic process (GO:0036109)2.97241860
79synaptic vesicle maturation (GO:0016188)2.97129694
80regulation of neuronal synaptic plasticity (GO:0048168)2.95467402
81creatine metabolic process (GO:0006600)2.95112331
82regulation of fatty acid oxidation (GO:0046320)2.94584200
83sodium ion export (GO:0071436)2.94373584
84branched-chain amino acid catabolic process (GO:0009083)2.92678284
85sarcomere organization (GO:0045214)2.92396629
86positive regulation of dendritic spine development (GO:0060999)2.90426633
87regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.90026977
88ventricular cardiac muscle cell action potential (GO:0086005)2.89901322
89regulation of synapse structural plasticity (GO:0051823)2.89815233
90amino-acid betaine metabolic process (GO:0006577)2.89528218
91monocarboxylic acid catabolic process (GO:0072329)2.89309694
92sarcoplasmic reticulum calcium ion transport (GO:0070296)2.86196567
93protein localization to synapse (GO:0035418)2.85470023
94valine metabolic process (GO:0006573)2.84775887
95* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82126195
96locomotory exploration behavior (GO:0035641)2.81101773
97carnitine metabolic process (GO:0009437)2.80470069
98regulation of sequestering of triglyceride (GO:0010889)2.80015541
99cysteine metabolic process (GO:0006534)2.79159054
100branched-chain amino acid metabolic process (GO:0009081)2.78737811
101regulation of actin filament-based movement (GO:1903115)2.78333294
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77680486
103layer formation in cerebral cortex (GO:0021819)2.76721649
104cerebellar Purkinje cell layer development (GO:0021680)2.76638039
105neurotransmitter uptake (GO:0001504)2.76214970
106regulation of female receptivity (GO:0045924)2.75583854
107aromatic amino acid family catabolic process (GO:0009074)2.75225810
108regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74517574
109neuronal action potential propagation (GO:0019227)2.73765083
110activation of protein kinase A activity (GO:0034199)2.72617372
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72367991
112ketone body metabolic process (GO:1902224)2.71622842
113cellular potassium ion homeostasis (GO:0030007)2.69816859
114regulation of voltage-gated calcium channel activity (GO:1901385)2.69786523
115membrane repolarization (GO:0086009)2.69578457
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68375857
117response to mercury ion (GO:0046689)2.68034261
118positive regulation of membrane potential (GO:0045838)2.67469079
119L-amino acid import (GO:0043092)2.67450949
120plasma membrane repair (GO:0001778)2.67072280
121regulation of glutamate receptor signaling pathway (GO:1900449)2.66234170
122fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65967305
123kynurenine metabolic process (GO:0070189)2.65441515
124hydrogen ion transmembrane transport (GO:1902600)2.65364706
125mechanosensory behavior (GO:0007638)2.64810506
126glycine transport (GO:0015816)2.64442407
127amino acid import (GO:0043090)2.63619916
128gamma-aminobutyric acid signaling pathway (GO:0007214)2.63325649
129sodium ion homeostasis (GO:0055078)2.63056149
130synaptic vesicle endocytosis (GO:0048488)2.62780791
131ionotropic glutamate receptor signaling pathway (GO:0035235)2.61752338
132regulation of mitotic spindle organization (GO:0060236)2.61154316
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.60568226
134regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60055064
135* respiratory electron transport chain (GO:0022904)2.59917583
136positive regulation of fatty acid oxidation (GO:0046321)2.59865855
137myofibril assembly (GO:0030239)2.59425084
138neuronal ion channel clustering (GO:0045161)2.59406287
139drug transmembrane transport (GO:0006855)2.58860945
140lung epithelium development (GO:0060428)2.58101276
141regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57854676
142positive regulation of cellular amine metabolic process (GO:0033240)2.56378464
143postsynaptic membrane organization (GO:0001941)2.56139148
144regulation of oxidative phosphorylation (GO:0002082)2.55088066
145gamma-aminobutyric acid transport (GO:0015812)2.55041170
146regulation of sulfur metabolic process (GO:0042762)2.54597807
147regulation of cell communication by electrical coupling (GO:0010649)2.54368303
148oxaloacetate metabolic process (GO:0006107)2.53792111
149drug catabolic process (GO:0042737)2.53197127
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53001262
151alpha-amino acid catabolic process (GO:1901606)2.52264848
152purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52099952
153purine nucleoside triphosphate biosynthetic process (GO:0009145)2.51574656
154* electron transport chain (GO:0022900)2.51489249
155fatty acid homeostasis (GO:0055089)2.51401329
156cellular amino acid catabolic process (GO:0009063)2.50023749
157acyl-CoA biosynthetic process (GO:0071616)2.49220921
158thioester biosynthetic process (GO:0035384)2.49220921
159establishment of mitochondrion localization (GO:0051654)2.47824935
160regulation of dopamine metabolic process (GO:0042053)2.47184408
161regulation of catecholamine metabolic process (GO:0042069)2.47184408
162detection of calcium ion (GO:0005513)2.46498597
163regulation of dendritic spine morphogenesis (GO:0061001)2.45424123
164exploration behavior (GO:0035640)2.45413103
165vitamin transmembrane transport (GO:0035461)2.44306288
166C4-dicarboxylate transport (GO:0015740)2.40466080
167one-carbon compound transport (GO:0019755)2.40333195
168response to auditory stimulus (GO:0010996)2.38879513
169positive regulation of potassium ion transmembrane transport (GO:1901381)2.38389507
170female mating behavior (GO:0060180)2.37890678
171regulation of vesicle fusion (GO:0031338)2.35018942
172membrane depolarization during action potential (GO:0086010)2.34910527
173long-term memory (GO:0007616)2.32635590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.31071171
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.30817774
3EZH2_22144423_ChIP-Seq_EOC_Human3.31664277
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.10474552
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.62014250
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61167417
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55095428
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.52572180
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28549657
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.11900476
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09556022
12DROSHA_22980978_ChIP-Seq_HELA_Human2.09543964
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03415364
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01154122
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.96604481
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92208271
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89222688
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.88150019
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87353371
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86495320
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86495320
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85988100
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77915207
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77337816
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76332384
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.74668858
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.70424619
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66743799
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64162564
30ZNF263_19887448_ChIP-Seq_K562_Human1.51039712
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51015545
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49977676
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.49273523
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.47660368
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46405716
36TBX20_22328084_ChIP-Seq_HEART_Mouse1.45059894
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.45059894
38REST_21632747_ChIP-Seq_MESCs_Mouse1.44619943
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44560369
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.44161305
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43483711
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.36693965
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35400904
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.34871310
45SMC4_20622854_ChIP-Seq_HELA_Human1.34151099
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33502387
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31635223
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30106650
49P68_20966046_ChIP-Seq_HELA_Human1.29831663
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29561397
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28258257
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27042979
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26195465
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.24145994
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22876123
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22643644
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22343606
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21593928
59GBX2_23144817_ChIP-Seq_PC3_Human1.19992213
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19927752
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18758523
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15205316
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14223832
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.13836389
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.13437018
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13290540
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11928749
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10761034
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09774846
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09658555
71CLOCK_20551151_ChIP-Seq_293T_Human1.09275223
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08022797
73CTCF_27219007_Chip-Seq_Bcells_Human1.08013917
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07954349
75KDM2B_26808549_Chip-Seq_K562_Human1.06924276
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06599255
77SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05917225
78OCT4_19829295_ChIP-Seq_ESCs_Human1.05808485
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04214066
80ZNF274_21170338_ChIP-Seq_K562_Hela1.04170852
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03927141
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.03040735
83RNF2_27304074_Chip-Seq_NSC_Mouse1.02784021
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02623681
85NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02430889
86E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02086120
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.01283864
88CTCF_20526341_ChIP-Seq_ESCs_Human0.98620593
89RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97487197
90AR_21572438_ChIP-Seq_LNCaP_Human0.97393626
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.97187720
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.96475590
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94530200
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94142486
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.93619302
96GATA1_19941826_ChIP-Seq_K562_Human0.93365515
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93189081
98MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92408067
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.91191645
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90289287
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90263653
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.90080376
103SA1_27219007_Chip-Seq_Bcells_Human0.88763069
104SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88467267
105SMAD4_21799915_ChIP-Seq_A2780_Human0.88311711
106RING1B_27294783_Chip-Seq_ESCs_Mouse0.88088199
107AR_19668381_ChIP-Seq_PC3_Human0.87899466
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87696765
109LXR_22292898_ChIP-Seq_THP-1_Human0.86941870
110KLF4_19829295_ChIP-Seq_ESCs_Human0.86289799
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86131180
112HTT_18923047_ChIP-ChIP_STHdh_Human0.85286363
113POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85121918
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85021789
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84594282
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84574182
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83876786
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83872549
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83825324
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83131394
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82369480
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82243795
123VDR_22108803_ChIP-Seq_LS180_Human0.81753221
124E2F1_20622854_ChIP-Seq_HELA_Human0.81585885
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80554771
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80476464
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80448419
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79958897
129XRN2_22483619_ChIP-Seq_HELA_Human0.79953180
130ETS1_20019798_ChIP-Seq_JURKAT_Human0.79815535
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79020855
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.78941414
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78646630
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77945548
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.77561395
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.76674058
137NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76384340
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76326847
139SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75503737
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75297667
141CREB1_26743006_Chip-Seq_LNCaP_Human0.75226873
142RXR_22108803_ChIP-Seq_LS180_Human0.74614350
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74267264
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.73591638
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73501434
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73253730
147HNF4A_19822575_ChIP-Seq_HepG2_Human0.73142094
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.72799743
149BCAT_22108803_ChIP-Seq_LS180_Human0.72118535
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71756910
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71248806
152STAT3_23295773_ChIP-Seq_U87_Human0.71219143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.75498220
2MP0005360_urolithiasis3.26595666
3MP0003646_muscle_fatigue3.16536435
4MP0004859_abnormal_synaptic_plasticity3.15900541
5MP0000751_myopathy3.14500687
6MP0004043_abnormal_pH_regulation2.95581369
7MP0002822_catalepsy2.92857165
8MP0004215_abnormal_myocardial_fiber2.90372923
9MP0002139_abnormal_hepatobiliary_system2.86670323
10MP0005085_abnormal_gallbladder_physiolo2.80037050
11MP0004084_abnormal_cardiac_muscle2.68014738
12MP0004130_abnormal_muscle_cell2.59938605
13MP0004036_abnormal_muscle_relaxation2.43118656
14MP0005646_abnormal_pituitary_gland2.32999108
15MP0005365_abnormal_bile_salt2.32148606
16MP0003122_maternal_imprinting2.28810329
17MP0005330_cardiomyopathy2.20398772
18MP0004145_abnormal_muscle_electrophysio2.02235430
19MP0005332_abnormal_amino_acid2.01828576
20MP0006036_abnormal_mitochondrial_physio1.94924066
21MP0003195_calcinosis1.91369741
22MP0008875_abnormal_xenobiotic_pharmacok1.91010346
23MP0003635_abnormal_synaptic_transmissio1.85955223
24MP0004270_analgesia1.77732297
25MP0003123_paternal_imprinting1.77713414
26MP0000749_muscle_degeneration1.77211715
27MP0002909_abnormal_adrenal_gland1.74883158
28MP0004087_abnormal_muscle_fiber1.72597631
29MP0003137_abnormal_impulse_conducting1.72157327
30MP0001968_abnormal_touch/_nociception1.71867635
31MP0005670_abnormal_white_adipose1.71100323
32MP0005666_abnormal_adipose_tissue1.70589615
33MP0005620_abnormal_muscle_contractility1.69541076
34MP0000747_muscle_weakness1.68501284
35MP0002972_abnormal_cardiac_muscle1.66228016
36MP0008775_abnormal_heart_ventricle1.63519230
37MP0001502_abnormal_circadian_rhythm1.62336161
38MP0008961_abnormal_basal_metabolism1.60857123
39MP0010329_abnormal_lipoprotein_level1.60309214
40MP0004484_altered_response_of1.60174554
41MP0001529_abnormal_vocalization1.57873160
42MP0003806_abnormal_nucleotide_metabolis1.55920255
43MP0003329_amyloid_beta_deposits1.53445839
44MP0003252_abnormal_bile_duct1.52836326
45MP0005535_abnormal_body_temperature1.50124497
46MP0009745_abnormal_behavioral_response1.50119093
47MP0009780_abnormal_chondrocyte_physiolo1.48750330
48MP0004085_abnormal_heartbeat1.47653536
49MP0002733_abnormal_thermal_nociception1.46400138
50MP0000678_abnormal_parathyroid_gland1.46174396
51MP0002557_abnormal_social/conspecific_i1.45519243
52MP0002118_abnormal_lipid_homeostasis1.43687054
53MP0002064_seizures1.43261061
54MP0001970_abnormal_pain_threshold1.42475624
55MP0006138_congestive_heart_failure1.41616475
56MP0001905_abnormal_dopamine_level1.39226243
57MP0002106_abnormal_muscle_physiology1.38580158
58MP0004185_abnormal_adipocyte_glucose1.38524939
59MP0002269_muscular_atrophy1.38211508
60MP0003880_abnormal_central_pattern1.38059728
61MP0000566_synostosis1.37748766
62MP0001544_abnormal_cardiovascular_syste1.34567284
63MP0005385_cardiovascular_system_phenoty1.34567284
64MP0001486_abnormal_startle_reflex1.34364726
65MP0002735_abnormal_chemical_nociception1.33229335
66MP0009046_muscle_twitch1.32397903
67MP0003690_abnormal_glial_cell1.31236133
68MP0001984_abnormal_olfaction1.30290965
69MP0002063_abnormal_learning/memory/cond1.29969179
70MP0002971_abnormal_brown_adipose1.29059640
71MP0002272_abnormal_nervous_system1.28379745
72MP0006276_abnormal_autonomic_nervous1.27902448
73MP0005584_abnormal_enzyme/coenzyme_acti1.25909510
74MP0004885_abnormal_endolymph1.21668129
75MP0002249_abnormal_larynx_morphology1.20908507
76MP0010630_abnormal_cardiac_muscle1.20820857
77MP0002736_abnormal_nociception_after1.19294730
78MP0002066_abnormal_motor_capabilities/c1.19277041
79MP0005375_adipose_tissue_phenotype1.19151336
80MP0008995_early_reproductive_senescence1.17756120
81MP0005083_abnormal_biliary_tract1.17732233
82MP0000750_abnormal_muscle_regeneration1.16645731
83MP0005369_muscle_phenotype1.13063083
84MP0001765_abnormal_ion_homeostasis1.11790351
85MP0005551_abnormal_eye_electrophysiolog1.10663447
86MP0000013_abnormal_adipose_tissue1.09735271
87MP0009840_abnormal_foam_cell1.06505634
88MP0002078_abnormal_glucose_homeostasis1.05218128
89MP0000759_abnormal_skeletal_muscle1.04178432
90MP0001666_abnormal_nutrient_absorption1.03780817
91MP0009643_abnormal_urine_homeostasis1.03471813
92MP0005167_abnormal_blood-brain_barrier1.01445829
93MP0008872_abnormal_physiological_respon1.00558129
94MP0000230_abnormal_systemic_arterial1.00255807
95MP0002229_neurodegeneration0.99223151
96MP0001501_abnormal_sleep_pattern0.98697608
97MP0002882_abnormal_neuron_morphology0.98643689
98MP0008569_lethality_at_weaning0.98594541
99MP0003633_abnormal_nervous_system0.96696016
100MP0002572_abnormal_emotion/affect_behav0.96573456
101MP0004924_abnormal_behavior0.96464981
102MP0005386_behavior/neurological_phenoty0.96464981
103MP0001440_abnormal_grooming_behavior0.96030254
104MP0004811_abnormal_neuron_physiology0.95699522
105MP0004019_abnormal_vitamin_homeostasis0.94759144
106MP0004147_increased_porphyrin_level0.93959850
107MP0004233_abnormal_muscle_weight0.93923432
108MP0003221_abnormal_cardiomyocyte_apopto0.93064774
109MP0003121_genomic_imprinting0.92400934
110MP0009697_abnormal_copulation0.92368708
111MP0005319_abnormal_enzyme/_coenzyme0.91963124
112MP0005636_abnormal_mineral_homeostasis0.90569542
113MP0003879_abnormal_hair_cell0.89914318
114MP0003878_abnormal_ear_physiology0.89789523
115MP0005377_hearing/vestibular/ear_phenot0.89789523
116MP0000955_abnormal_spinal_cord0.89048838
117MP0000920_abnormal_myelination0.87791234
118MP0002734_abnormal_mechanical_nocicepti0.87415215
119MP0002332_abnormal_exercise_endurance0.86127404
120MP0008874_decreased_physiological_sensi0.85076929
121MP0002184_abnormal_innervation0.84656923
122MP0003631_nervous_system_phenotype0.83885483
123MP0001963_abnormal_hearing_physiology0.83105785
124MP0000003_abnormal_adipose_tissue0.81995347
125MP0006035_abnormal_mitochondrial_morpho0.80240874
126MP0005645_abnormal_hypothalamus_physiol0.80183096
127MP0000609_abnormal_liver_physiology0.79633777
128MP0001346_abnormal_lacrimal_gland0.78981863
129MP0000604_amyloidosis0.78816378
130MP0001756_abnormal_urination0.78780575
131MP0005423_abnormal_somatic_nervous0.78228083
132MP0000639_abnormal_adrenal_gland0.75034321
133MP0003075_altered_response_to0.74964971
134MP0001485_abnormal_pinna_reflex0.74958220
135MP0005165_increased_susceptibility_to0.74804275
136MP0002152_abnormal_brain_morphology0.74617782
137MP0002069_abnormal_eating/drinking_beha0.73844579
138MP0000631_abnormal_neuroendocrine_gland0.73594010
139MP0002132_abnormal_respiratory_system0.73210277
140MP0003191_abnormal_cellular_cholesterol0.72661564
141MP0002067_abnormal_sensory_capabilities0.72654632
142MP0005409_darkened_coat_color0.72478545
143MP0004142_abnormal_muscle_tone0.71604065
144MP0003698_abnormal_male_reproductive0.70466781
145MP0004133_heterotaxia0.69729050
146MP0004742_abnormal_vestibular_system0.68536857
147MP0002160_abnormal_reproductive_system0.68234265

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.21778755
2Sudden death (HP:0001699)4.17824865
3Myoglobinuria (HP:0002913)4.07088438
4Ketoacidosis (HP:0001993)3.92065512
5Hyperglycinuria (HP:0003108)3.82739061
6Hypoglycemic coma (HP:0001325)3.81226124
7Ketosis (HP:0001946)3.75835749
8Exercise-induced muscle cramps (HP:0003710)3.73601945
9Truncus arteriosus (HP:0001660)3.66308053
10Gout (HP:0001997)3.64417247
11Bundle branch block (HP:0011710)3.54105900
12Abnormality of glycine metabolism (HP:0010895)3.47958715
13Abnormality of serine family amino acid metabolism (HP:0010894)3.47958715
14Muscle fiber splitting (HP:0003555)3.35412379
15Epileptic encephalopathy (HP:0200134)3.35027070
16Myokymia (HP:0002411)3.34752206
17Increased serum pyruvate (HP:0003542)3.34070166
18Calf muscle hypertrophy (HP:0008981)3.33212588
19Hyperammonemia (HP:0001987)3.31782376
20Abnormality of glycolysis (HP:0004366)3.26153920
21Atrial fibrillation (HP:0005110)3.23901253
22Abnormality of fatty-acid metabolism (HP:0004359)3.22341907
23Ventricular fibrillation (HP:0001663)3.21712685
24Cerebral hypomyelination (HP:0006808)3.19162432
25Muscle hypertrophy of the lower extremities (HP:0008968)3.18574854
26Atrioventricular block (HP:0001678)3.16136276
27Syncope (HP:0001279)3.13178282
28Ventricular tachycardia (HP:0004756)3.09123974
29Heart block (HP:0012722)3.08227924
30Atonic seizures (HP:0010819)3.07151614
31Abnormal mitochondria in muscle tissue (HP:0008316)3.04292777
32Hyperglycinemia (HP:0002154)3.02866245
33Primary atrial arrhythmia (HP:0001692)3.02472666
34Hyporeflexia of lower limbs (HP:0002600)2.97975626
35Prolonged QT interval (HP:0001657)2.93381217
36Increased circulating renin level (HP:0000848)2.90919073
37Abnormal gallbladder physiology (HP:0012438)2.89547470
38Cholecystitis (HP:0001082)2.89547470
39Hyperthyroidism (HP:0000836)2.89449854
40Acute necrotizing encephalopathy (HP:0006965)2.88809903
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84502385
42Dicarboxylic aciduria (HP:0003215)2.84502385
43Supraventricular tachycardia (HP:0004755)2.84063905
44Ankle clonus (HP:0011448)2.80994519
45Difficulty running (HP:0009046)2.79170640
46Febrile seizures (HP:0002373)2.77829393
47Abnormal atrioventricular conduction (HP:0005150)2.77048770
48Supraventricular arrhythmia (HP:0005115)2.76583796
49Focal motor seizures (HP:0011153)2.75128723
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72417102
51Rhabdomyolysis (HP:0003201)2.68130412
52Ventricular arrhythmia (HP:0004308)2.66263253
53Abnormality of binocular vision (HP:0011514)2.65834361
54Diplopia (HP:0000651)2.65834361
55Morphological abnormality of the inner ear (HP:0011390)2.56183940
56Hyperuricemia (HP:0002149)2.55947331
57Increased purine levels (HP:0004368)2.55947331
58Xanthomatosis (HP:0000991)2.54504226
59Right ventricular cardiomyopathy (HP:0011663)2.53890676
60Palpitations (HP:0001962)2.48899207
61Abnormality of the calf musculature (HP:0001430)2.46541888
62Deep venous thrombosis (HP:0002625)2.46490981
63Prolonged partial thromboplastin time (HP:0003645)2.45786828
64Abnormality of cochlea (HP:0000375)2.44661134
65Progressive macrocephaly (HP:0004481)2.43584646
66Hyperlipoproteinemia (HP:0010980)2.43368513
67Generalized aminoaciduria (HP:0002909)2.41352513
68Hyperinsulinemic hypoglycemia (HP:0000825)2.36526036
69Limb dystonia (HP:0002451)2.35997758
70Metabolic acidosis (HP:0001942)2.35609886
71Dysmetric saccades (HP:0000641)2.35538569
72Hepatocellular necrosis (HP:0001404)2.33541288
73Mitochondrial inheritance (HP:0001427)2.33180170
74Reticulocytosis (HP:0001923)2.32674178
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31225758
76Hypokalemic alkalosis (HP:0001949)2.30624970
77Abnormal EKG (HP:0003115)2.29912325
78Obstructive sleep apnea (HP:0002870)2.29880365
79Abnormality of the left ventricular outflow tract (HP:0011103)2.28122538
80Subaortic stenosis (HP:0001682)2.28122538
81Dilated cardiomyopathy (HP:0001644)2.24631340
82Abnormality of purine metabolism (HP:0004352)2.24316035
83Absence seizures (HP:0002121)2.23916512
84Cerebral edema (HP:0002181)2.23341692
85Muscle stiffness (HP:0003552)2.23306420
86Torticollis (HP:0000473)2.22427518
87Metabolic alkalosis (HP:0200114)2.22327493
88Lipoatrophy (HP:0100578)2.22232340
89Peripheral hypomyelination (HP:0007182)2.21773214
90Absent/shortened dynein arms (HP:0200106)2.19438555
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.19438555
92Abnormal eating behavior (HP:0100738)2.18757843
93Supranuclear gaze palsy (HP:0000605)2.17308041
94Pheochromocytoma (HP:0002666)2.17107968
95Progressive cerebellar ataxia (HP:0002073)2.16264990
96Alacrima (HP:0000522)2.15388268
97Abnormal social behavior (HP:0012433)2.14184170
98Impaired social interactions (HP:0000735)2.14184170
99Lethargy (HP:0001254)2.13813436
100CNS hypomyelination (HP:0003429)2.13639957
101Emotional lability (HP:0000712)2.13408683
102Proximal tubulopathy (HP:0000114)2.12969150
103Asymmetric septal hypertrophy (HP:0001670)2.12671552
104Hyperkalemia (HP:0002153)2.12369007
105Delayed CNS myelination (HP:0002188)2.12301071
106Seborrheic dermatitis (HP:0001051)2.11723647
107Intrahepatic cholestasis (HP:0001406)2.11525045
108Action tremor (HP:0002345)2.10691473
109Visual hallucinations (HP:0002367)2.10031452
110Bowel incontinence (HP:0002607)2.09416553
111Myotonia (HP:0002486)2.08790104
112Increased CSF lactate (HP:0002490)2.07165847
113Abnormal ciliary motility (HP:0012262)2.06955484
114Focal seizures (HP:0007359)2.06263558
115Abnormal respiratory epithelium morphology (HP:0012253)2.05896087
116Abnormal respiratory motile cilium morphology (HP:0005938)2.05896087
117Increased intramyocellular lipid droplets (HP:0012240)2.05806846
118Hypoalphalipoproteinemia (HP:0003233)2.05283183
119Anxiety (HP:0000739)2.05129515
120Increased muscle lipid content (HP:0009058)2.03849125
121EMG: myopathic abnormalities (HP:0003458)2.03465111
122Abnormal respiratory motile cilium physiology (HP:0012261)2.02347535
123Abnormality of glutamine family amino acid metabolism (HP:0010902)2.01975029
124Late onset (HP:0003584)2.01560938
125Abnormal large intestine physiology (HP:0012700)2.00278923
126Dysdiadochokinesis (HP:0002075)2.00179343
127Hepatic necrosis (HP:0002605)2.00114418
128Neonatal onset (HP:0003623)1.98882162
129Generalized tonic-clonic seizures (HP:0002069)1.97509404
130Acute encephalopathy (HP:0006846)1.97363444
131Leukodystrophy (HP:0002415)1.96875827
132Poor eye contact (HP:0000817)1.96773840
133Status epilepticus (HP:0002133)1.96436004
134Hypoglycemic seizures (HP:0002173)1.95540915
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95408518
136Postural instability (HP:0002172)1.95339588
137Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95060138
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94721086
139Vomiting (HP:0002013)1.93619944
140Abnormality of serum amino acid levels (HP:0003112)1.92198801
141Abnormality of the corticospinal tract (HP:0002492)1.92000268
142Choreoathetosis (HP:0001266)1.91956356
143Dialeptic seizures (HP:0011146)1.91044102
144Cholelithiasis (HP:0001081)1.90953804
145Delayed myelination (HP:0012448)1.90886765
146Spastic gait (HP:0002064)1.88159606
147Cerebral hemorrhage (HP:0001342)1.86557755
148Atelectasis (HP:0100750)1.85746633
149Neuroendocrine neoplasm (HP:0100634)1.85622941
150Delusions (HP:0000746)1.85600080
151Abnormality of renin-angiotensin system (HP:0000847)1.83272664
152Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82667530
153Degeneration of the lateral corticospinal tracts (HP:0002314)1.82667530
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82040259
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82040259
156Abnormal gallbladder morphology (HP:0012437)1.81456655
157Morphological abnormality of the pyramidal tract (HP:0002062)1.81164242
158Hyperaldosteronism (HP:0000859)1.80964505
159Sensorimotor neuropathy (HP:0007141)1.80567799
160Focal dystonia (HP:0004373)1.80488364
161Acanthocytosis (HP:0001927)1.79209466
162Sleep apnea (HP:0010535)1.77530496
163Craniofacial dystonia (HP:0012179)1.75481458
164Annular pancreas (HP:0001734)1.74741021
165Epileptiform EEG discharges (HP:0011182)1.73287583
166Tetraplegia (HP:0002445)1.70258911
167Myopathic facies (HP:0002058)1.68204982
168Urinary bladder sphincter dysfunction (HP:0002839)1.67510586
169Urinary urgency (HP:0000012)1.66496000
170Genetic anticipation (HP:0003743)1.63777278
171Poikilocytosis (HP:0004447)1.63303705
172Hypsarrhythmia (HP:0002521)1.62985747
173Intellectual disability, profound (HP:0002187)1.61224638
174Papilledema (HP:0001085)1.59523596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME13.44407648
2EPHA42.99015063
3TRIB32.87823371
4WNK42.67677853
5BCKDK2.56762663
6PDK42.55984605
7PDK32.55984605
8PHKG12.34484945
9PHKG22.34484945
10NEK12.30970482
11LMTK22.24441673
12NTRK32.15448053
13PINK12.12877946
14PRKD32.08719274
15TTN2.00394351
16OXSR11.97544079
17MAPK151.94646843
18BRSK11.91092946
19DAPK21.90755604
20PKN21.82668743
21STK391.79910390
22MAP2K41.78664084
23STK381.78208844
24RIPK41.76715918
25EIF2AK11.73364154
26MAP3K91.73257359
27PAK61.72283806
28TAOK11.70443505
29KSR21.69200288
30DMPK1.57707156
31MAP3K41.52449938
32WNK11.49266408
33PDK21.45025604
34WNK31.44545578
35INSRR1.43919010
36OBSCN1.42561782
37CAMKK11.39742677
38CDK121.37066398
39MAPKAPK31.32883783
40PAK31.32742957
41CAMK1G1.28516157
42MAPKAPK51.28179881
43MAP3K71.23709277
44MAPK131.22600113
45RIPK11.22156748
46DAPK11.21068804
47MUSK1.20698018
48NTRK11.16151219
49PDPK11.12539930
50CAMK1D1.05344920
51TIE11.04138198
52EPHB11.03718502
53MINK11.00989626
54CAMK10.99660651
55CDK150.95671816
56PRKD10.95638165
57PLK20.95224141
58TESK10.95132673
59CDK11A0.94565430
60MST1R0.93966060
61MAP3K120.93704598
62PDK10.93243488
63CDK140.92158141
64TYRO30.90610847
65MYLK0.90380338
66CDK180.88682188
67CAMK2D0.88422227
68CDK50.88090629
69SCYL20.86556413
70PRKAA20.86338099
71ERBB20.85412435
72PRKCH0.85412215
73TTK0.84128803
74STK110.82415084
75BMPR20.82226449
76MAPK100.81666408
77MAP3K20.80081437
78TNK20.79793286
79RET0.78860696
80CSNK1E0.78499662
81SGK4940.75960793
82SGK2230.75960793
83PRKAA10.75780542
84NTRK20.75720217
85MAPK120.75526403
86CAMK2G0.74819189
87MAP3K60.72743906
88MAP2K70.71465859
89CDC42BPA0.71270863
90CAMK2A0.70837044
91NEK60.69857680
92CDK190.69546345
93MET0.69230608
94ERN10.66664230
95SIK10.66582349
96BMX0.66062185
97MAP3K10.64003476
98ICK0.63255875
99CAMK40.63184681
100SGK30.62815073
101SGK10.62600275
102PIK3CA0.60721336
103WEE10.60653925
104CAMKK20.58709314
105UHMK10.58547600
106EPHA20.57401924
107GRK70.57164406
108PRKACG0.57113769
109TNIK0.56954559
110CSNK1A1L0.56698763
111PDGFRA0.56574000
112PKN10.55859721
113SIK20.55230615
114DYRK1A0.55005965
115RAF10.53740344
116MARK20.53321419
117PRKG10.52408319
118RPS6KA30.51865424
119STK240.51827841
120PRKD20.51425636
121PTK2B0.51102810
122CAMK2B0.50869040
123ALK0.50177461
124FER0.49372671
125PRKCG0.47682324
126CCNB10.47245406
127SRPK10.46227988
128MAPK110.46156327
129MAP3K130.45130909
130CDK10.44508163
131MARK10.44487271
132GSK3B0.44049518
133FGFR20.43541921
134STK160.43452449
135PRKACA0.42675535
136CSNK1G20.41589335
137LIMK10.40947076
138LATS20.40771408
139TAOK30.40308105
140GRK50.40133989
141TESK20.40081957
142PRKACB0.40016800
143JAK20.39039381
144FGFR40.38354107
145MAP2K10.37190240
146FES0.36791701
147PTK60.36690518

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.42130088
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.18851187
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00502970
4Propanoate metabolism_Homo sapiens_hsa006402.98208553
5Fatty acid degradation_Homo sapiens_hsa000712.76979038
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.76912302
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64876299
8Butanoate metabolism_Homo sapiens_hsa006502.47289731
9Fatty acid metabolism_Homo sapiens_hsa012122.35225650
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22316334
11Arginine biosynthesis_Homo sapiens_hsa002202.05605794
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84972218
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.75982188
14Tryptophan metabolism_Homo sapiens_hsa003801.70710781
15PPAR signaling pathway_Homo sapiens_hsa033201.69546250
16Pyruvate metabolism_Homo sapiens_hsa006201.66716362
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65736671
18Proteasome_Homo sapiens_hsa030501.63432068
19Carbon metabolism_Homo sapiens_hsa012001.61724719
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54154421
21Cardiac muscle contraction_Homo sapiens_hsa042601.53614257
22beta-Alanine metabolism_Homo sapiens_hsa004101.48118211
23Huntingtons disease_Homo sapiens_hsa050161.46834383
24Bile secretion_Homo sapiens_hsa049761.44680390
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44352940
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36433031
27Fatty acid elongation_Homo sapiens_hsa000621.35658084
28Peroxisome_Homo sapiens_hsa041461.20723257
29Dilated cardiomyopathy_Homo sapiens_hsa054141.17450617
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17272552
31GABAergic synapse_Homo sapiens_hsa047271.13112015
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12841909
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11555959
34Fatty acid biosynthesis_Homo sapiens_hsa000611.09380380
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08708644
36Olfactory transduction_Homo sapiens_hsa047401.06120533
37Gastric acid secretion_Homo sapiens_hsa049711.01059288
38Insulin secretion_Homo sapiens_hsa049111.00012592
39Circadian entrainment_Homo sapiens_hsa047130.97184251
40Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96565362
41Biosynthesis of amino acids_Homo sapiens_hsa012300.94045916
42Chemical carcinogenesis_Homo sapiens_hsa052040.93498460
43Starch and sucrose metabolism_Homo sapiens_hsa005000.92645751
44Glutamatergic synapse_Homo sapiens_hsa047240.92534470
45Steroid biosynthesis_Homo sapiens_hsa001000.92522972
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90013636
47Salivary secretion_Homo sapiens_hsa049700.88710899
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84679313
49Nicotine addiction_Homo sapiens_hsa050330.84676911
50Morphine addiction_Homo sapiens_hsa050320.84474235
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84391451
52Oocyte meiosis_Homo sapiens_hsa041140.83970064
53Glycerolipid metabolism_Homo sapiens_hsa005610.83913999
54Glucagon signaling pathway_Homo sapiens_hsa049220.83606807
55Lysine degradation_Homo sapiens_hsa003100.83394999
56Synaptic vesicle cycle_Homo sapiens_hsa047210.82136807
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.79916435
58Vitamin B6 metabolism_Homo sapiens_hsa007500.78854470
59Long-term potentiation_Homo sapiens_hsa047200.77208785
60Phenylalanine metabolism_Homo sapiens_hsa003600.76713929
61Arginine and proline metabolism_Homo sapiens_hsa003300.76487371
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76232642
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76041505
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.75240695
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75053159
66Collecting duct acid secretion_Homo sapiens_hsa049660.74096940
67Calcium signaling pathway_Homo sapiens_hsa040200.73971141
68Amphetamine addiction_Homo sapiens_hsa050310.72882273
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72671345
70Renin secretion_Homo sapiens_hsa049240.71850415
71Serotonergic synapse_Homo sapiens_hsa047260.71297117
72Type II diabetes mellitus_Homo sapiens_hsa049300.70733786
73Insulin resistance_Homo sapiens_hsa049310.69502322
74Oxytocin signaling pathway_Homo sapiens_hsa049210.68968677
75Parkinsons disease_Homo sapiens_hsa050120.68356486
76Histidine metabolism_Homo sapiens_hsa003400.66766764
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66161570
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65741029
79Retinol metabolism_Homo sapiens_hsa008300.65156337
80Sulfur metabolism_Homo sapiens_hsa009200.64712765
81Fat digestion and absorption_Homo sapiens_hsa049750.64304934
82Oxidative phosphorylation_Homo sapiens_hsa001900.63325618
83Dopaminergic synapse_Homo sapiens_hsa047280.63265926
84Cholinergic synapse_Homo sapiens_hsa047250.62945008
85cAMP signaling pathway_Homo sapiens_hsa040240.62130377
86Complement and coagulation cascades_Homo sapiens_hsa046100.61673913
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61202104
88One carbon pool by folate_Homo sapiens_hsa006700.59393828
89Alzheimers disease_Homo sapiens_hsa050100.58325405
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57223426
91Folate biosynthesis_Homo sapiens_hsa007900.57173842
92Circadian rhythm_Homo sapiens_hsa047100.55921331
93Protein export_Homo sapiens_hsa030600.55871820
94Phototransduction_Homo sapiens_hsa047440.54074665
95AMPK signaling pathway_Homo sapiens_hsa041520.53007182
96Pancreatic secretion_Homo sapiens_hsa049720.52373787
97Cocaine addiction_Homo sapiens_hsa050300.51851788
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51658494
99Fructose and mannose metabolism_Homo sapiens_hsa000510.51326251
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50793105
101Tyrosine metabolism_Homo sapiens_hsa003500.50419228
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.50357675
103ABC transporters_Homo sapiens_hsa020100.49707640
104Insulin signaling pathway_Homo sapiens_hsa049100.49099857
105Metabolic pathways_Homo sapiens_hsa011000.49083381
106Spliceosome_Homo sapiens_hsa030400.48488933
107Taste transduction_Homo sapiens_hsa047420.47387965
108Glutathione metabolism_Homo sapiens_hsa004800.46888461
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.46289655
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.45374563
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45145291
112Thyroid hormone synthesis_Homo sapiens_hsa049180.44040585
113GnRH signaling pathway_Homo sapiens_hsa049120.43869592
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.43707874
115Caffeine metabolism_Homo sapiens_hsa002320.41388330
116Ovarian steroidogenesis_Homo sapiens_hsa049130.41237518
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41029915
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40730167
119Dorso-ventral axis formation_Homo sapiens_hsa043200.38007431
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.37851459
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37797250
122Vitamin digestion and absorption_Homo sapiens_hsa049770.36389249

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