MT-ND5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.94124701
2locomotory exploration behavior (GO:0035641)5.56872942
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19684820
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15551119
5sodium ion export (GO:0071436)4.65444585
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.61303303
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58688412
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.47539068
9layer formation in cerebral cortex (GO:0021819)4.34379038
10cellular potassium ion homeostasis (GO:0030007)4.31770197
11glutamate secretion (GO:0014047)4.31119403
12vocalization behavior (GO:0071625)4.28534478
13cell communication by electrical coupling (GO:0010644)4.21155374
14regulation of synaptic vesicle exocytosis (GO:2000300)4.20285893
15regulation of histone H3-K27 methylation (GO:0061085)4.18785189
16synaptic vesicle exocytosis (GO:0016079)4.09108056
17regulation of synapse structural plasticity (GO:0051823)4.03280883
18activation of protein kinase A activity (GO:0034199)3.99212896
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.89919559
20regulation of glutamate receptor signaling pathway (GO:1900449)3.87950332
21exploration behavior (GO:0035640)3.85050693
22neurotransmitter secretion (GO:0007269)3.83457493
23regulation of synaptic vesicle transport (GO:1902803)3.74291306
24dendritic spine morphogenesis (GO:0060997)3.71513537
25proline transport (GO:0015824)3.67101403
26potassium ion import (GO:0010107)3.58208816
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.56707101
28regulation of neuronal synaptic plasticity (GO:0048168)3.54390583
29vitamin transmembrane transport (GO:0035461)3.53198359
30glycine transport (GO:0015816)3.52685507
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50245829
32cell communication involved in cardiac conduction (GO:0086065)3.46626557
33regulation of ARF protein signal transduction (GO:0032012)3.40905259
34glucocorticoid receptor signaling pathway (GO:0042921)3.39853462
35regulation of glucose import in response to insulin stimulus (GO:2001273)3.36261211
36gamma-aminobutyric acid transport (GO:0015812)3.34075203
37membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.33943249
38negative regulation of erythrocyte differentiation (GO:0045647)3.30904841
39neuromuscular process controlling balance (GO:0050885)3.28149819
40regulation of nucleobase-containing compound transport (GO:0032239)3.26475780
41regulation of RNA export from nucleus (GO:0046831)3.25688381
42adherens junction assembly (GO:0034333)3.25031973
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23550386
44cellular sodium ion homeostasis (GO:0006883)3.22251685
45membrane repolarization (GO:0086009)3.22136947
46desmosome organization (GO:0002934)3.18472214
47neuronal action potential propagation (GO:0019227)3.14568035
48long-term memory (GO:0007616)3.14230317
49regulation of cholesterol homeostasis (GO:2000188)3.11853740
50regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.09791734
51focal adhesion assembly (GO:0048041)3.07512916
52cell-substrate adherens junction assembly (GO:0007045)3.07512916
53regulation of clathrin-mediated endocytosis (GO:2000369)3.07028651
54protein localization to synapse (GO:0035418)3.05280057
55NADH metabolic process (GO:0006734)3.05136463
56membrane repolarization during action potential (GO:0086011)3.03354580
57response to pheromone (GO:0019236)3.03066308
58potassium ion homeostasis (GO:0055075)3.02805132
59COPI coating of Golgi vesicle (GO:0048205)3.00613475
60Golgi transport vesicle coating (GO:0048200)3.00613475
61regulation of dendritic spine morphogenesis (GO:0061001)3.00086259
62dendrite morphogenesis (GO:0048813)2.96121208
63regulation of membrane repolarization (GO:0060306)2.95007957
64neurotransmitter-gated ion channel clustering (GO:0072578)2.94427685
65neurotransmitter transport (GO:0006836)2.94078360
66positive regulation of membrane potential (GO:0045838)2.93816694
67regulation of NFAT protein import into nucleus (GO:0051532)2.93780687
68ionotropic glutamate receptor signaling pathway (GO:0035235)2.93482909
69neuromuscular process controlling posture (GO:0050884)2.92340817
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.91871695
71alanine transport (GO:0032328)2.91707969
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88794629
73positive regulation of potassium ion transmembrane transport (GO:1901381)2.88136690
74cell volume homeostasis (GO:0006884)2.87107845
75establishment of nucleus localization (GO:0040023)2.86835862
76mannose metabolic process (GO:0006013)2.86765894
77retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86277474
78auditory behavior (GO:0031223)2.85751530
79vesicle transport along microtubule (GO:0047496)2.85277716
80cerebellar Purkinje cell differentiation (GO:0021702)2.84490673
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83513129
82stress granule assembly (GO:0034063)2.80917582
83regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78986134
84regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78723018
85regulation of neurotransmitter levels (GO:0001505)2.76425590
86prepulse inhibition (GO:0060134)2.73925867
87ethanol oxidation (GO:0006069)2.72402005
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.71925860
89atrioventricular valve morphogenesis (GO:0003181)2.71592723
90lung epithelium development (GO:0060428)2.70869268
91corticosteroid receptor signaling pathway (GO:0031958)2.70004192
92embryonic process involved in female pregnancy (GO:0060136)2.69755262
93synaptic transmission, glutamatergic (GO:0035249)2.68169732
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68030421
95positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66235211
96dicarboxylic acid biosynthetic process (GO:0043650)2.66022498
97negative regulation of potassium ion transmembrane transport (GO:1901380)2.65594872
98cerebellar Purkinje cell layer development (GO:0021680)2.64842491
99dendritic spine organization (GO:0097061)2.64036935
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63125986
101positive regulation of synapse maturation (GO:0090129)2.62240494
102response to auditory stimulus (GO:0010996)2.62229049
103semaphorin-plexin signaling pathway (GO:0071526)2.61415798
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.60957958
105positive regulation of potassium ion transport (GO:0043268)2.60896956
106membrane depolarization during action potential (GO:0086010)2.60812401
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.59787210
108activation of Rac GTPase activity (GO:0032863)2.59769358
109innervation (GO:0060384)2.59502663
110creatine metabolic process (GO:0006600)2.59135226
111regulation of synaptic plasticity (GO:0048167)2.58895665
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58753442
113amino acid import (GO:0043090)2.58075526
114plasma membrane repair (GO:0001778)2.57909490
115cell-cell junction maintenance (GO:0045217)2.57083681
116ethanol metabolic process (GO:0006067)2.56746314
117regulation of early endosome to late endosome transport (GO:2000641)2.55820813
118protein retention in ER lumen (GO:0006621)2.54171774
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.53305331
120cerebellar granule cell differentiation (GO:0021707)2.53145591
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.53089845
122chemosensory behavior (GO:0007635)2.52946540
123positive regulation of sodium ion transport (GO:0010765)2.52735808
124intracellular estrogen receptor signaling pathway (GO:0030520)2.52563404
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.51121641
126embryonic camera-type eye morphogenesis (GO:0048596)2.50893037
127cardiac conduction (GO:0061337)2.50524547
128regulation of calcium ion transmembrane transporter activity (GO:1901019)2.49932403
129regulation of calcium ion transmembrane transport (GO:1903169)2.49932403
130regulation of ion transmembrane transporter activity (GO:0032412)2.49683919
131synaptic vesicle endocytosis (GO:0048488)2.49657574
132neuron-neuron synaptic transmission (GO:0007270)2.49610864
133regulation of neurotransmitter secretion (GO:0046928)2.49130849
134negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.48849619
135regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48782868
136mating behavior (GO:0007617)2.48668320
137glutamate receptor signaling pathway (GO:0007215)2.48354589
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48202101
139negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47581287
140regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.47353850
141negative regulation of histone methylation (GO:0031061)2.46929078
142regulation of postsynaptic membrane potential (GO:0060078)2.46768947
143regulation of extracellular matrix disassembly (GO:0010715)2.46502979
144actin filament depolymerization (GO:0030042)2.46146977
145regulation of calcium ion-dependent exocytosis (GO:0017158)2.46027222
146histone H3-K9 demethylation (GO:0033169)2.41502703
147negative regulation of myotube differentiation (GO:0010832)2.40116106
148negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.38578707
149maternal placenta development (GO:0001893)2.37199880
150basement membrane organization (GO:0071711)2.36429970
151positive regulation of gene expression, epigenetic (GO:0045815)2.34495918
152L-amino acid import (GO:0043092)2.34063017
153negative regulation of cell size (GO:0045792)2.33894268
154regulation of interleukin-13 production (GO:0032656)2.31485015
155cellular response to reactive nitrogen species (GO:1902170)2.30961543
156apoptotic process involved in morphogenesis (GO:0060561)2.30535802
157cell junction maintenance (GO:0034331)2.29975134
158planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29670193
159negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.28846695
160regulation of cholesterol metabolic process (GO:0090181)2.26975578
161regulation of extracellular matrix organization (GO:1903053)2.25910366
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25847644
163regulation of histone H3-K4 methylation (GO:0051569)2.24705484
164motile cilium assembly (GO:0044458)2.24414515
165response to parathyroid hormone (GO:0071107)2.24002813
166cellular response to prostaglandin stimulus (GO:0071379)2.23616740
167cellular response to nitric oxide (GO:0071732)2.22214420
168sodium ion homeostasis (GO:0055078)2.21808913
169urea cycle (GO:0000050)2.21539796
170response to vitamin A (GO:0033189)2.20760360
171urea metabolic process (GO:0019627)2.20213704
172negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.20130733
173cellular response to epidermal growth factor stimulus (GO:0071364)2.20113507
174response to mercury ion (GO:0046689)2.19838346
175proline biosynthetic process (GO:0006561)2.19776538
176regulation of bile acid biosynthetic process (GO:0070857)2.19576133
177histone H3-K4 methylation (GO:0051568)2.19409024
178regulation of cholesterol biosynthetic process (GO:0045540)2.19201603
179positive regulation of extracellular matrix organization (GO:1903055)2.18454562
180response to epidermal growth factor (GO:0070849)2.17610387
181phosphate ion transmembrane transport (GO:0035435)2.17285840
182G1 DNA damage checkpoint (GO:0044783)2.17197379
183regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.17003810
184regulation of fatty acid beta-oxidation (GO:0031998)2.16908479
185dopamine receptor signaling pathway (GO:0007212)2.16730064
186regulation of mitotic spindle organization (GO:0060236)2.16600527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.02383947
2DROSHA_22980978_ChIP-Seq_HELA_Human2.82239612
3MYC_22102868_ChIP-Seq_BL_Human2.60910803
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.60796600
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39355918
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39180830
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29531468
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28417562
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22311849
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22311849
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20780553
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20566839
13TCF7_22412390_ChIP-Seq_EML_Mouse2.20120518
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17284707
15RACK7_27058665_Chip-Seq_MCF-7_Human2.15484090
16REST_21632747_ChIP-Seq_MESCs_Mouse2.13827263
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10637325
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08579798
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05949263
20CLOCK_20551151_ChIP-Seq_293T_Human1.94845787
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93352927
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.91108741
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88507439
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.86685661
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84954472
26SMC4_20622854_ChIP-Seq_HELA_Human1.84908719
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84464337
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.84270856
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.81400906
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.80211597
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79344345
32GBX2_23144817_ChIP-Seq_PC3_Human1.76056495
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75401247
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75179487
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73958073
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71114732
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.70306796
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69886176
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.69342825
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.67276772
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65805863
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62258404
43KDM2B_26808549_Chip-Seq_K562_Human1.60059977
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59891368
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59443125
46P68_20966046_ChIP-Seq_HELA_Human1.55772142
47CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.55402563
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54940265
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.53753325
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50024360
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49566741
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48613115
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47836834
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47106993
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45060952
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44535183
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44490484
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.44426570
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44381445
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44102760
61AR_21572438_ChIP-Seq_LNCaP_Human1.43768492
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.43154015
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42688104
64VDR_21846776_ChIP-Seq_THP-1_Human1.42633437
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41791471
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41394845
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40980592
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40108942
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.35237756
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35052267
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.33772393
72AR_19668381_ChIP-Seq_PC3_Human1.33057979
73ZNF274_21170338_ChIP-Seq_K562_Hela1.32076389
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32014128
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31678915
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31471755
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.30697928
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30148918
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29443346
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27250543
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26979213
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26840442
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.26702900
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25061159
85SMAD4_21799915_ChIP-Seq_A2780_Human1.24831342
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23639472
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23622589
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21892721
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21297547
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20520268
91ZNF263_19887448_ChIP-Seq_K562_Human1.20124742
92NCOR1_26117541_ChIP-Seq_K562_Human1.20055079
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.19242067
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19102458
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18536633
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17252879
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17051506
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16962838
99KDM2B_26808549_Chip-Seq_DND41_Human1.16837444
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.16010049
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.15951411
102LXR_22158963_ChIP-Seq_LIVER_Mouse1.15802225
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15158002
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14950001
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.13500301
106GATA1_19941826_ChIP-Seq_K562_Human1.12486462
107SMAD4_21741376_ChIP-Seq_HESCs_Human1.11249538
108STAT3_23295773_ChIP-Seq_U87_Human1.11069480
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11027122
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10813667
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10153409
112FOXA2_19822575_ChIP-Seq_HepG2_Human1.09192721
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.08583113
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07667651
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07505346
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06953812
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05774310
118SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05292808
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.04695876
120TP63_22573176_ChIP-Seq_HFKS_Human1.04473903
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.04461717
122GATA1_19941827_ChIP-Seq_MEL_Mouse1.04205709
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02401884
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02197640
125RXR_22108803_ChIP-Seq_LS180_Human1.01989749
126TP53_16413492_ChIP-PET_HCT116_Human1.00545690
127FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00351818
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99215519
129STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97675614
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.96618575
131GATA6_25053715_ChIP-Seq_YYC3_Human0.95923541
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95418892
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95240320
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.95118706
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94994843
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93742650
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.92979875
138KLF4_19829295_ChIP-Seq_ESCs_Human0.92884207
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92667299
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92521152
141CREB1_26743006_Chip-Seq_LNCaP_Human0.92481864
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.92080396
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91947016
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91818038
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91800096
146CTCF_27219007_Chip-Seq_Bcells_Human0.91383890
147AHR_22903824_ChIP-Seq_MCF-7_Human0.91017218
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90977599
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.90889012
150TBX20_22080862_ChIP-Seq_HEART_Mouse0.90889012
151MITF_21258399_ChIP-Seq_MELANOMA_Human0.90691781
152LXR_22292898_ChIP-Seq_THP-1_Human0.90602342
153THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89818577
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89692796
155AR_25329375_ChIP-Seq_VCAP_Human0.89422669
156MAF_26560356_Chip-Seq_TH1_Human0.89223038
157ISL1_27105846_Chip-Seq_CPCs_Mouse0.89095716
158STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88899631
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88092687
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87499552
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87136475
162TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87031982
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.86314005
164TCF4_23295773_ChIP-Seq_U87_Human0.86149959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.06263152
2MP0005409_darkened_coat_color3.46826742
3MP0003635_abnormal_synaptic_transmissio3.41823137
4MP0009780_abnormal_chondrocyte_physiolo3.10552099
5MP0004270_analgesia3.09450609
6MP0003705_abnormal_hypodermis_morpholog2.86854251
7MP0005670_abnormal_white_adipose2.80235606
8MP0005076_abnormal_cell_differentiation2.77958310
9MP0002822_catalepsy2.71127239
10MP0004043_abnormal_pH_regulation2.56130088
11MP0002063_abnormal_learning/memory/cond2.55876607
12MP0002909_abnormal_adrenal_gland2.54854216
13MP0009745_abnormal_behavioral_response2.44214926
14MP0008961_abnormal_basal_metabolism2.36049401
15MP0000751_myopathy2.26112478
16MP0002064_seizures2.21287786
17MP0002249_abnormal_larynx_morphology2.15304824
18MP0002139_abnormal_hepatobiliary_system2.15174610
19MP0009046_muscle_twitch2.14848604
20MP0000678_abnormal_parathyroid_gland2.04951928
21MP0005423_abnormal_somatic_nervous2.04203398
22MP0004215_abnormal_myocardial_fiber2.03567822
23MP0002009_preneoplasia2.00946151
24MP0001486_abnormal_startle_reflex1.96084220
25MP0003880_abnormal_central_pattern1.95109866
26MP0004885_abnormal_endolymph1.94079944
27MP0002837_dystrophic_cardiac_calcinosis1.93505628
28MP0002734_abnormal_mechanical_nocicepti1.90618151
29MP0008569_lethality_at_weaning1.86743069
30MP0002572_abnormal_emotion/affect_behav1.85176250
31MP0004130_abnormal_muscle_cell1.84097804
32MP0004264_abnormal_extraembryonic_tissu1.79206248
33MP0004782_abnormal_surfactant_physiolog1.72722756
34MP0003879_abnormal_hair_cell1.69807052
35MP0004084_abnormal_cardiac_muscle1.69336182
36MP0003283_abnormal_digestive_organ1.68873784
37MP0002272_abnormal_nervous_system1.66650849
38MP0003329_amyloid_beta_deposits1.66600457
39MP0000013_abnormal_adipose_tissue1.66023560
40MP0004858_abnormal_nervous_system1.61030757
41MP0010329_abnormal_lipoprotein_level1.58783072
42MP0001501_abnormal_sleep_pattern1.58297647
43MP0003646_muscle_fatigue1.55926660
44MP0009115_abnormal_fat_cell1.53972802
45MP0000566_synostosis1.53074442
46MP0001968_abnormal_touch/_nociception1.52650135
47MP0005058_abnormal_lysosome_morphology1.52577007
48MP0002396_abnormal_hematopoietic_system1.52471497
49MP0004233_abnormal_muscle_weight1.52298141
50MP0001348_abnormal_lacrimal_gland1.51658983
51MP0005365_abnormal_bile_salt1.50896078
52MP0004145_abnormal_muscle_electrophysio1.50065803
53MP0002877_abnormal_melanocyte_morpholog1.45895220
54MP0003868_abnormal_feces_composition1.44020200
55MP0002971_abnormal_brown_adipose1.43950354
56MP0000569_abnormal_digit_pigmentation1.42350859
57MP0009672_abnormal_birth_weight1.41617851
58MP0004811_abnormal_neuron_physiology1.41441902
59MP0010234_abnormal_vibrissa_follicle1.41274405
60MP0004036_abnormal_muscle_relaxation1.35451620
61MP0001440_abnormal_grooming_behavior1.35450752
62MP0002970_abnormal_white_adipose1.35215739
63MP0002733_abnormal_thermal_nociception1.31256492
64MP0005386_behavior/neurological_phenoty1.30076244
65MP0004924_abnormal_behavior1.30076244
66MP0003787_abnormal_imprinting1.30045484
67MP0001849_ear_inflammation1.28828561
68MP0005451_abnormal_body_composition1.25329491
69MP0004484_altered_response_of1.25002768
70MP0005187_abnormal_penis_morphology1.24759951
71MP0001730_embryonic_growth_arrest1.24667937
72MP0005646_abnormal_pituitary_gland1.23445621
73MP0000003_abnormal_adipose_tissue1.23300633
74MP0002557_abnormal_social/conspecific_i1.22905150
75MP0002067_abnormal_sensory_capabilities1.22256562
76MP0003633_abnormal_nervous_system1.21134959
77MP0001970_abnormal_pain_threshold1.20577553
78MP0000747_muscle_weakness1.17985165
79MP0005535_abnormal_body_temperature1.17779709
80MP0004085_abnormal_heartbeat1.16949335
81MP0004087_abnormal_muscle_fiber1.15126830
82MP0002796_impaired_skin_barrier1.15077909
83MP0001666_abnormal_nutrient_absorption1.14907835
84MP0003137_abnormal_impulse_conducting1.14634558
85MP0000955_abnormal_spinal_cord1.14371844
86MP0003091_abnormal_cell_migration1.13573568
87MP0003566_abnormal_cell_adhesion1.13158733
88MP0004019_abnormal_vitamin_homeostasis1.13145108
89MP0002184_abnormal_innervation1.11967994
90MP0005623_abnormal_meninges_morphology1.11491953
91MP0005620_abnormal_muscle_contractility1.09991381
92MP0005330_cardiomyopathy1.09481830
93MP0008775_abnormal_heart_ventricle1.09279520
94MP0002066_abnormal_motor_capabilities/c1.08166927
95MP0005503_abnormal_tendon_morphology1.06046100
96MP0005167_abnormal_blood-brain_barrier1.02130913
97MP0001346_abnormal_lacrimal_gland1.01024434
98MP0002118_abnormal_lipid_homeostasis1.00257398
99MP0005375_adipose_tissue_phenotype0.99317236
100MP0002972_abnormal_cardiac_muscle0.97950195
101MP0003300_gastrointestinal_ulcer0.97526241
102MP0002735_abnormal_chemical_nociception0.97302333
103MP0005666_abnormal_adipose_tissue0.96861426
104MP0002166_altered_tumor_susceptibility0.96840746
105MP0002234_abnormal_pharynx_morphology0.95101859
106MP0009840_abnormal_foam_cell0.93392493
107MP0001502_abnormal_circadian_rhythm0.92692372
108MP0002882_abnormal_neuron_morphology0.91774342
109MP0000778_abnormal_nervous_system0.89967293
110MP0003690_abnormal_glial_cell0.89590161
111MP0002089_abnormal_postnatal_growth/wei0.89052809
112MP0002069_abnormal_eating/drinking_beha0.87133094
113MP0009643_abnormal_urine_homeostasis0.87115061
114MP0002269_muscular_atrophy0.85639665
115MP0003631_nervous_system_phenotype0.85448456
116MP0003115_abnormal_respiratory_system0.83171897
117MP0002078_abnormal_glucose_homeostasis0.83114755
118MP0003122_maternal_imprinting0.82938355
119MP0001177_atelectasis0.82291369
120MP0002106_abnormal_muscle_physiology0.81919401
121MP0001765_abnormal_ion_homeostasis0.80839901
122MP0003045_fibrosis0.80729490
123MP0002152_abnormal_brain_morphology0.80592998
124MP0004185_abnormal_adipocyte_glucose0.80481950
125MP0002108_abnormal_muscle_morphology0.80480036
126MP0005360_urolithiasis0.80191953
127MP0001299_abnormal_eye_distance/0.80145183
128MP0003172_abnormal_lysosome_physiology0.79990598
129MP0008872_abnormal_physiological_respon0.79028507
130MP0003183_abnormal_peptide_metabolism0.78393094
131MP0003075_altered_response_to0.77030941
132MP0000733_abnormal_muscle_development0.76995895
133MP0005621_abnormal_cell_physiology0.76519613
134MP0005645_abnormal_hypothalamus_physiol0.76211748
135MP0010630_abnormal_cardiac_muscle0.74424518
136MP0002736_abnormal_nociception_after0.73616220
137MP0003959_abnormal_lean_body0.73511972
138MP0006138_congestive_heart_failure0.73393664
139MP0001270_distended_abdomen0.73331542
140MP0003453_abnormal_keratinocyte_physiol0.72697786
141MP0002098_abnormal_vibrissa_morphology0.72575085
142MP0002090_abnormal_vision0.72118451
143MP0001731_abnormal_postnatal_growth0.71459554
144MP0000604_amyloidosis0.69975996
145MP0005369_muscle_phenotype0.69111007
146MP0006036_abnormal_mitochondrial_physio0.69083566
147MP0003111_abnormal_nucleus_morphology0.69074032
148MP0008874_decreased_physiological_sensi0.68890940
149MP0003984_embryonic_growth_retardation0.68882972
150MP0005334_abnormal_fat_pad0.67340343
151MP0000759_abnormal_skeletal_muscle0.66152720
152MP0000609_abnormal_liver_physiology0.65582174
153MP0008875_abnormal_xenobiotic_pharmacok0.65133777
154MP0010352_gastrointestinal_tract_polyps0.65022325
155MP0004381_abnormal_hair_follicle0.64625484
156MP0000266_abnormal_heart_morphology0.64313645
157MP0005501_abnormal_skin_physiology0.63226173
158MP0008057_abnormal_DNA_replication0.63103815
159MP0001672_abnormal_embryogenesis/_devel0.62629454
160MP0005380_embryogenesis_phenotype0.62629454
161MP0002088_abnormal_embryonic_growth/wei0.61929840

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.79880439
2Visual hallucinations (HP:0002367)4.43254456
3Focal motor seizures (HP:0011153)4.07190987
4Ventricular fibrillation (HP:0001663)3.87994314
5Action tremor (HP:0002345)3.72082634
6Papilledema (HP:0001085)3.68952616
7Focal seizures (HP:0007359)3.59604046
8Bundle branch block (HP:0011710)3.55288650
9Deep venous thrombosis (HP:0002625)3.51764756
10Depression (HP:0000716)3.01768913
11Impaired social interactions (HP:0000735)2.96405261
12Abnormal social behavior (HP:0012433)2.96405261
13Postural instability (HP:0002172)2.93628966
14Dysmetric saccades (HP:0000641)2.91618625
15Poor eye contact (HP:0000817)2.90697904
16Genetic anticipation (HP:0003743)2.89017032
17Bronchomalacia (HP:0002780)2.86998918
18Progressive cerebellar ataxia (HP:0002073)2.86994801
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.84715133
20Dysdiadochokinesis (HP:0002075)2.83319264
21Exercise-induced myalgia (HP:0003738)2.82227174
22Ankle clonus (HP:0011448)2.78825993
23Macroorchidism (HP:0000053)2.77600091
24Hyperactive renin-angiotensin system (HP:0000841)2.72510885
25Urethral obstruction (HP:0000796)2.71889098
26Generalized tonic-clonic seizures (HP:0002069)2.70089214
27Abnormality of the fingertips (HP:0001211)2.69815920
28Urinary bladder sphincter dysfunction (HP:0002839)2.69070920
29Sudden death (HP:0001699)2.67897490
30Abnormality of the lower motor neuron (HP:0002366)2.65826797
31Absence seizures (HP:0002121)2.63119950
32Supranuclear gaze palsy (HP:0000605)2.62749321
33Impaired vibration sensation in the lower limbs (HP:0002166)2.61062284
34Anxiety (HP:0000739)2.55776872
35Prolonged QT interval (HP:0001657)2.55075277
36Gout (HP:0001997)2.54329874
37Hemiplegia (HP:0002301)2.53632922
38Hemorrhage of the eye (HP:0011885)2.52088133
39Atelectasis (HP:0100750)2.48709641
40Epileptic encephalopathy (HP:0200134)2.46419487
41Urinary urgency (HP:0000012)2.46149426
42Mutism (HP:0002300)2.46097220
43Torticollis (HP:0000473)2.42880092
44Broad-based gait (HP:0002136)2.42455268
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.42165172
46Truncus arteriosus (HP:0001660)2.40012105
47Insomnia (HP:0100785)2.38319686
48Flat acetabular roof (HP:0003180)2.37791339
49Broad face (HP:0000283)2.34300388
50Syncope (HP:0001279)2.33994922
51Heart block (HP:0012722)2.32516417
52Abnormal EKG (HP:0003115)2.32150205
53Ketoacidosis (HP:0001993)2.30544062
54Intention tremor (HP:0002080)2.27037165
55Atrioventricular block (HP:0001678)2.24938903
56Agitation (HP:0000713)2.24312625
57Bowel incontinence (HP:0002607)2.24255966
58Impaired smooth pursuit (HP:0007772)2.23033412
59Dysmetria (HP:0001310)2.20968086
60Febrile seizures (HP:0002373)2.20696262
61Atonic seizures (HP:0010819)2.20037775
62Ventricular arrhythmia (HP:0004308)2.19992253
63Resting tremor (HP:0002322)2.19924237
64Hypercortisolism (HP:0001578)2.19569522
65Abnormal eating behavior (HP:0100738)2.18607347
66Enlarged penis (HP:0000040)2.17541307
67Sparse lateral eyebrow (HP:0005338)2.17064241
68Gaze-evoked nystagmus (HP:0000640)2.16918670
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15079774
70Atrial fibrillation (HP:0005110)2.14289161
71Ankyloglossia (HP:0010296)2.13949715
72Broad palm (HP:0001169)2.13387837
73Dialeptic seizures (HP:0011146)2.12216427
74Elfin facies (HP:0004428)2.10933349
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10252287
76Asymmetry of the thorax (HP:0001555)2.10026160
77Focal dystonia (HP:0004373)2.10009888
78Increased circulating renin level (HP:0000848)2.09412666
79Pseudobulbar signs (HP:0002200)2.08943407
80Primary atrial arrhythmia (HP:0001692)2.08694075
81Exercise-induced muscle cramps (HP:0003710)2.08660670
82Myoglobinuria (HP:0002913)2.05720959
83Pointed chin (HP:0000307)2.04801583
84Abnormality of ocular smooth pursuit (HP:0000617)2.04602190
85Abnormal atrioventricular conduction (HP:0005150)2.04588893
86Difficulty running (HP:0009046)2.03801966
87Hyperacusis (HP:0010780)2.03439176
88Megalencephaly (HP:0001355)2.02179670
89Obstructive sleep apnea (HP:0002870)2.01745524
90Distal lower limb amyotrophy (HP:0008944)2.01242965
91Peripheral hypomyelination (HP:0007182)2.00419484
92Status epilepticus (HP:0002133)1.98658745
93Truncal ataxia (HP:0002078)1.98577592
94Bradykinesia (HP:0002067)1.98130144
95Adrenal overactivity (HP:0002717)1.98061280
96Right ventricular cardiomyopathy (HP:0011663)1.97921615
97Seborrheic dermatitis (HP:0001051)1.97563568
98J-shaped sella turcica (HP:0002680)1.96262701
99Abnormal large intestine physiology (HP:0012700)1.95800331
100Abnormality of the thoracic spine (HP:0100711)1.91313760
101Craniofacial dystonia (HP:0012179)1.90548904
102Abnormality of chloride homeostasis (HP:0011422)1.90403344
103Insidious onset (HP:0003587)1.89960395
104Termporal pattern (HP:0011008)1.89960395
105Hypoglycemic coma (HP:0001325)1.89704656
106Drooling (HP:0002307)1.89437153
107Excessive salivation (HP:0003781)1.89437153
108Supraventricular tachycardia (HP:0004755)1.88183650
109Tetraplegia (HP:0002445)1.87184778
110Increased nuchal translucency (HP:0010880)1.85028417
111Annular pancreas (HP:0001734)1.84345867
112Abnormality of renin-angiotensin system (HP:0000847)1.84340991
113Septate vagina (HP:0001153)1.84244974
114Hammertoe (HP:0001765)1.84037738
115Neoplasm of the heart (HP:0100544)1.84021473
116Lip pit (HP:0100267)1.83991661
117Stereotypic behavior (HP:0000733)1.83957253
118Lymphangioma (HP:0100764)1.83341591
119Postural tremor (HP:0002174)1.83323301
120Supraventricular arrhythmia (HP:0005115)1.83286737
121Long eyelashes (HP:0000527)1.82114261
122Hypercholesterolemia (HP:0003124)1.81570355
123Abnormality of binocular vision (HP:0011514)1.81546402
124Diplopia (HP:0000651)1.81546402
125Protrusio acetabuli (HP:0003179)1.80324577
126Renovascular hypertension (HP:0100817)1.80005620
127Hyperkalemia (HP:0002153)1.79746433
128Overriding aorta (HP:0002623)1.78567011
129Shallow orbits (HP:0000586)1.78566345
130Distal lower limb muscle weakness (HP:0009053)1.78343707
131Cerebral aneurysm (HP:0004944)1.77252405
132Growth hormone excess (HP:0000845)1.77052300
133Pheochromocytoma (HP:0002666)1.76961096
134Neurofibrillary tangles (HP:0002185)1.76926124
135Hyperaldosteronism (HP:0000859)1.76553037
136Vertebral arch anomaly (HP:0008438)1.76382858
137Lower limb asymmetry (HP:0100559)1.76235800
138Spastic gait (HP:0002064)1.75210952
139Impaired vibratory sensation (HP:0002495)1.74917935
140Ketosis (HP:0001946)1.74561223
141Papillary thyroid carcinoma (HP:0002895)1.73379088
142Clonus (HP:0002169)1.72394763
143Hyperphosphatemia (HP:0002905)1.71747845
144Aneurysm (HP:0002617)1.71569166
145Hyperparathyroidism (HP:0000843)1.70651703
146EEG with generalized epileptiform discharges (HP:0011198)1.70566481
147Hypsarrhythmia (HP:0002521)1.69255701
148Upper limb amyotrophy (HP:0009129)1.68869246
149Distal upper limb amyotrophy (HP:0007149)1.68869246
150Complement deficiency (HP:0004431)1.68262902
151Neuronal loss in central nervous system (HP:0002529)1.67691671
152Cerebral inclusion bodies (HP:0100314)1.67668590
153Hypokalemic alkalosis (HP:0001949)1.67232513
154Hyperthyroidism (HP:0000836)1.66731070
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.65245750
156Segmental peripheral demyelination/remyelination (HP:0003481)1.65212751
157Foot dorsiflexor weakness (HP:0009027)1.65170301
158Abnormality of the salivary glands (HP:0010286)1.63164366
159Metaphyseal cupping (HP:0003021)1.62177162
160Recurrent otitis media (HP:0000403)1.61784800
161Advanced eruption of teeth (HP:0006288)1.60677618
162Abnormality of the aortic arch (HP:0012303)1.58746035
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58577460
164Male infertility (HP:0003251)1.57790168
165Onion bulb formation (HP:0003383)1.56535564
166Lower limb amyotrophy (HP:0007210)1.54821354
167Abnormality of the foot musculature (HP:0001436)1.54562411
168Reticulocytosis (HP:0001923)1.53991301
169Precocious puberty (HP:0000826)1.53444869
170Hand muscle atrophy (HP:0009130)1.53074920
171Renal salt wasting (HP:0000127)1.53000693
172Bell-shaped thorax (HP:0001591)1.52536154
173Flat cornea (HP:0007720)1.52509481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.43742531
2NTRK33.24925729
3PRKD33.11392448
4FGFR42.89514485
5EEF2K2.69561975
6MARK12.63931700
7EPHA42.62276910
8PRPF4B2.61422667
9MAP3K42.34589454
10SMG12.33460123
11PAK62.29803428
12NEK12.24402163
13KSR22.19740480
14TRIB32.18437273
15DAPK22.17344511
16AKT32.17072901
17CAMKK12.16780462
18RIPK12.15573989
19MINK12.15031145
20STK382.06715341
21LMTK22.03908988
22TAOK11.98828673
23ERN11.98245827
24PHKG21.71707683
25PHKG11.71707683
26MAP2K41.66005813
27PKN21.64432774
28NTRK21.63815396
29EPHA21.54834021
30CAMK1G1.52476426
31MAP3K21.51414605
32NTRK11.50226282
33MAPKAPK31.44467201
34MAP3K101.43458031
35MST1R1.40459357
36ALK1.38027516
37LATS21.37041614
38RIPK41.36344147
39PAK31.33892389
40MAPK151.32993007
41DMPK1.30664454
42WNK41.25362683
43TYRO31.25076403
44RET1.22560612
45PRKCH1.21037567
46SCYL21.19547930
47CDK51.19277677
48MAP2K71.17919660
49KSR11.16588948
50MAP3K71.11069108
51WNK11.10772875
52EPHB11.09722280
53STK111.09608771
54WNK31.09501316
55CAMK11.09363712
56CAMK1D1.08158028
57PDK31.05579156
58PDK41.05579156
59SIK21.01840978
60PINK11.00376538
61MAPK111.00233144
62CDC42BPA0.97652179
63PDGFRA0.95874685
64SGK30.91568496
65CAMKK20.90292353
66HIPK20.83890038
67BMX0.82737049
68NEK60.82227100
69MAPK120.81513645
70PDK10.81277924
71PRKCG0.77021785
72TNK20.76928237
73PDPK10.76495063
74MARK20.75390099
75MAP3K130.74364393
76FRK0.73143525
77UHMK10.72298916
78SGK10.72214072
79MAP3K10.71627358
80TRPM70.71458294
81MAP3K60.70741521
82CDK40.68303351
83SGK2230.68237520
84SGK4940.68237520
85CDK120.66653095
86CDK90.65639982
87CAMK40.64733822
88DAPK10.63580716
89RPS6KA30.63485221
90PDGFRB0.63240507
91TESK10.62954748
92PRKD20.62799052
93SIK30.62338786
94SGK20.62096285
95MET0.61943597
96INSRR0.61898880
97RPS6KB20.60457014
98FES0.59254023
99MAP2K20.59231888
100PRKAA10.59198109
101BRSK10.58013917
102NME10.57924163
103MAPK100.57672266
104MAP3K140.55539321
105DYRK1A0.53130376
106CSNK1G20.52504698
107FER0.52452817
108PTK60.52236876
109LATS10.51639532
110ICK0.50973294
111CAMK2A0.49091847
112JAK10.48797178
113PLK20.48788622
114PRKCZ0.48249822
115GSK3B0.48242610
116PRKAA20.47642488
117MELK0.47497433
118RPS6KA20.47374092
119PTK20.47338667
120CDK70.47312184
121PRKD10.47023925
122CDK60.46953679
123FGFR20.46733609
124CDK140.46239379
125CDK150.46066039
126DDR20.45560083
127OXSR10.45428611
128ITK0.45078513
129MAPK80.44773489
130MAPK70.44588618
131RAF10.43959790
132CDK20.43021714
133ERBB20.42316771
134SIK10.42298362
135CDK180.42213044
136MAPK30.41399065
137CHEK10.40811002
138MAPK140.40806486
139MAP4K10.40486851
140FYN0.40458441
141GRK50.40176013
142CDK11A0.39936014
143MTOR0.39666147
144BRD40.39274681
145FGFR10.38000811
146TTN0.37783112
147PIK3CA0.37538096
148FGFR30.36059205
149PRKACG0.35623213

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.78590552
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25529394
3Synaptic vesicle cycle_Homo sapiens_hsa047212.20439977
4Circadian entrainment_Homo sapiens_hsa047132.12632727
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.11087939
6Olfactory transduction_Homo sapiens_hsa047402.09278257
7Nicotine addiction_Homo sapiens_hsa050332.05422218
8Insulin secretion_Homo sapiens_hsa049112.04627886
9GABAergic synapse_Homo sapiens_hsa047272.03509891
10Long-term potentiation_Homo sapiens_hsa047202.02687904
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00897970
12Phenylalanine metabolism_Homo sapiens_hsa003601.98281465
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84466312
14Gastric acid secretion_Homo sapiens_hsa049711.84248975
15Histidine metabolism_Homo sapiens_hsa003401.81317304
16Glutamatergic synapse_Homo sapiens_hsa047241.79655636
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79184499
18Morphine addiction_Homo sapiens_hsa050321.76172450
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74904337
20Amphetamine addiction_Homo sapiens_hsa050311.74317666
21Salivary secretion_Homo sapiens_hsa049701.73047062
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65904560
23Dopaminergic synapse_Homo sapiens_hsa047281.60864646
24Type II diabetes mellitus_Homo sapiens_hsa049301.60240420
25Cholinergic synapse_Homo sapiens_hsa047251.56839079
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55086230
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42802902
28Oxytocin signaling pathway_Homo sapiens_hsa049211.40001721
29Renin secretion_Homo sapiens_hsa049241.39941969
30Chronic myeloid leukemia_Homo sapiens_hsa052201.33199426
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31746083
32Cocaine addiction_Homo sapiens_hsa050301.29149779
33Notch signaling pathway_Homo sapiens_hsa043301.27752906
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27066431
35Bile secretion_Homo sapiens_hsa049761.25696595
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25580811
37GnRH signaling pathway_Homo sapiens_hsa049121.21841321
38cAMP signaling pathway_Homo sapiens_hsa040241.20758093
39Thyroid cancer_Homo sapiens_hsa052161.19070635
40Dilated cardiomyopathy_Homo sapiens_hsa054141.17321542
41Butanoate metabolism_Homo sapiens_hsa006501.16381686
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15836612
43Calcium signaling pathway_Homo sapiens_hsa040201.15189454
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14522648
45Acute myeloid leukemia_Homo sapiens_hsa052211.14291656
46Glioma_Homo sapiens_hsa052141.10653701
47Other glycan degradation_Homo sapiens_hsa005111.10547591
48Dorso-ventral axis formation_Homo sapiens_hsa043201.08624455
49Glucagon signaling pathway_Homo sapiens_hsa049221.06459992
50Taste transduction_Homo sapiens_hsa047421.06061761
51Estrogen signaling pathway_Homo sapiens_hsa049151.05896634
52Thyroid hormone synthesis_Homo sapiens_hsa049181.03362847
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03019170
54Long-term depression_Homo sapiens_hsa047301.02892913
55Gap junction_Homo sapiens_hsa045401.01604702
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98990289
57Arginine biosynthesis_Homo sapiens_hsa002200.98718112
58Adherens junction_Homo sapiens_hsa045200.96226257
59mTOR signaling pathway_Homo sapiens_hsa041500.95718330
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93685532
61ABC transporters_Homo sapiens_hsa020100.93379270
62Fructose and mannose metabolism_Homo sapiens_hsa000510.92930501
63Tyrosine metabolism_Homo sapiens_hsa003500.92380720
64Prion diseases_Homo sapiens_hsa050200.91117963
65Fatty acid degradation_Homo sapiens_hsa000710.89001279
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85950543
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85321210
68mRNA surveillance pathway_Homo sapiens_hsa030150.84615459
69Insulin signaling pathway_Homo sapiens_hsa049100.84408037
70Melanogenesis_Homo sapiens_hsa049160.83902469
71Cardiac muscle contraction_Homo sapiens_hsa042600.83034274
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82899903
73Pancreatic secretion_Homo sapiens_hsa049720.82648669
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82369817
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81919310
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80813680
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.79553271
78Complement and coagulation cascades_Homo sapiens_hsa046100.78990871
79ErbB signaling pathway_Homo sapiens_hsa040120.78823395
80Insulin resistance_Homo sapiens_hsa049310.78822239
81Fatty acid metabolism_Homo sapiens_hsa012120.78326566
82Lysine degradation_Homo sapiens_hsa003100.77950878
83beta-Alanine metabolism_Homo sapiens_hsa004100.77873613
84Arginine and proline metabolism_Homo sapiens_hsa003300.75931852
85Serotonergic synapse_Homo sapiens_hsa047260.75765830
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75579098
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75051586
88Propanoate metabolism_Homo sapiens_hsa006400.74400838
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.74121225
90Pancreatic cancer_Homo sapiens_hsa052120.73880938
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73319698
92Circadian rhythm_Homo sapiens_hsa047100.67808224
93Oocyte meiosis_Homo sapiens_hsa041140.67574827
94Choline metabolism in cancer_Homo sapiens_hsa052310.64519106
95AMPK signaling pathway_Homo sapiens_hsa041520.64013119
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63256437
97Prostate cancer_Homo sapiens_hsa052150.63036788
98Endometrial cancer_Homo sapiens_hsa052130.62308235
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.60459964
100Axon guidance_Homo sapiens_hsa043600.60400302
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59489874
102Retinol metabolism_Homo sapiens_hsa008300.58691527
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.58082489
104Non-small cell lung cancer_Homo sapiens_hsa052230.57744444
105Biosynthesis of amino acids_Homo sapiens_hsa012300.57509779
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56761166
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56459167
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.56071363
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55421398
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54804800
111Focal adhesion_Homo sapiens_hsa045100.54497063
112Vitamin B6 metabolism_Homo sapiens_hsa007500.54247111
113B cell receptor signaling pathway_Homo sapiens_hsa046620.54074437
114Fatty acid biosynthesis_Homo sapiens_hsa000610.53261684
115Vitamin digestion and absorption_Homo sapiens_hsa049770.53228754
116VEGF signaling pathway_Homo sapiens_hsa043700.53054926
117MicroRNAs in cancer_Homo sapiens_hsa052060.52632736
118Renal cell carcinoma_Homo sapiens_hsa052110.50893901
119PPAR signaling pathway_Homo sapiens_hsa033200.49078113
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48682818
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.48649486
122Ovarian steroidogenesis_Homo sapiens_hsa049130.48441111
123Inositol phosphate metabolism_Homo sapiens_hsa005620.46941136
124MAPK signaling pathway_Homo sapiens_hsa040100.46260635
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46074682
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.45442233
127Rap1 signaling pathway_Homo sapiens_hsa040150.45354788
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44114021
129Carbon metabolism_Homo sapiens_hsa012000.43506389
130Endocytosis_Homo sapiens_hsa041440.38545132
131Prolactin signaling pathway_Homo sapiens_hsa049170.35495584
132Tight junction_Homo sapiens_hsa045300.35211955
133Starch and sucrose metabolism_Homo sapiens_hsa005000.34962806
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34221339

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