ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lysine metabolic process (GO:0006553)	4.13831340
2	lysine catabolic process (GO:0006554)	4.13831340
3	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.07560765
4	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.04283124
5	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.97738450
6	tricarboxylic acid cycle (GO:0006099)	3.82330103
7	carnitine shuttle (GO:0006853)	3.81048676
8	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.71633588
9	synaptic vesicle maturation (GO:0016188)	3.58044314
10	fatty acid transmembrane transport (GO:1902001)	3.57992338
11	cell communication by electrical coupling (GO:0010644)	3.55915491
12	cell communication involved in cardiac conduction (GO:0086065)	3.52638488
13	aspartate family amino acid catabolic process (GO:0009068)	3.52239658
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.47659395
15	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.44164837
16	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.43941198
17	locomotory exploration behavior (GO:0035641)	3.39867786
18	ethanol oxidation (GO:0006069)	3.39532214
19	2-oxoglutarate metabolic process (GO:0006103)	3.36944392
20	regulation of membrane repolarization (GO:0060306)	3.32234034
21	short-chain fatty acid metabolic process (GO:0046459)	3.29869093
22	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.29840381
23	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.28654265
24	cardiac muscle contraction (GO:0060048)	3.26106432
25	ventricular cardiac muscle cell action potential (GO:0086005)	3.25021971
26	cardiac myofibril assembly (GO:0055003)	3.22115510
27	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.21683554
28	regulation of sequestering of triglyceride (GO:0010889)	3.21658151
29	sodium ion export (GO:0071436)	3.20064838
30	vitamin transmembrane transport (GO:0035461)	3.19272577
31	fatty acid beta-oxidation (GO:0006635)	3.18875656
32	potassium ion import (GO:0010107)	3.18583438
33	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.16289242
34	ethanol metabolic process (GO:0006067)	3.15201033
35	carnitine transport (GO:0015879)	3.12268690
36	amino-acid betaine transport (GO:0015838)	3.12268690
37	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.10831594
38	plasma membrane repair (GO:0001778)	3.10346117
39	cellular ketone body metabolic process (GO:0046950)	3.10230401
40	regulation of fatty acid oxidation (GO:0046320)	3.09379321
41	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.06217441
42	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.05544822
43	NADH metabolic process (GO:0006734)	3.05318010
44	sarcomere organization (GO:0045214)	3.04535385
45	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.01591583
46	regulation of actin filament-based movement (GO:1903115)	3.00970581
47	regulation of early endosome to late endosome transport (GO:2000641)	3.00662574
48	activation of protein kinase A activity (GO:0034199)	3.00239429
49	mannose metabolic process (GO:0006013)	2.99777156
50	carnitine transmembrane transport (GO:1902603)	2.99752492
51	succinate metabolic process (GO:0006105)	2.98567843
52	positive regulation of synapse maturation (GO:0090129)	2.96831023
53	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.94736319
54	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.93492339
55	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.91143304
56	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.89119717
57	creatine metabolic process (GO:0006600)	2.88992293
58	* respiratory electron transport chain (GO:0022904)	2.87860818
59	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.87528928
60	cellular potassium ion homeostasis (GO:0030007)	2.87300648
61	cardiac conduction (GO:0061337)	2.86147631
62	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.85844608
63	positive regulation of fatty acid oxidation (GO:0046321)	2.85237088
64	membrane repolarization during action potential (GO:0086011)	2.84194338
65	regulation of cell communication by electrical coupling (GO:0010649)	2.83765796
66	relaxation of cardiac muscle (GO:0055119)	2.83303413
67	dicarboxylic acid biosynthetic process (GO:0043650)	2.83283086
68	cerebellar granule cell differentiation (GO:0021707)	2.82652656
69	membrane repolarization (GO:0086009)	2.82158511
70	tricarboxylic acid metabolic process (GO:0072350)	2.82138091
71	regulation of extracellular matrix disassembly (GO:0010715)	2.81424031
72	regulation of ARF protein signal transduction (GO:0032012)	2.81281945
73	regulation of coenzyme metabolic process (GO:0051196)	2.80992658
74	regulation of cofactor metabolic process (GO:0051193)	2.80992658
75	fatty acid oxidation (GO:0019395)	2.80382036
76	myofibril assembly (GO:0030239)	2.79314643
77	cellular sodium ion homeostasis (GO:0006883)	2.78400677
78	* electron transport chain (GO:0022900)	2.78063873
79	positive regulation of extracellular matrix organization (GO:1903055)	2.77822619
80	quaternary ammonium group transport (GO:0015697)	2.77501437
81	potassium ion homeostasis (GO:0055075)	2.77020998
82	lipid oxidation (GO:0034440)	2.76901316
83	glycine transport (GO:0015816)	2.76672409
84	regulation of synapse structural plasticity (GO:0051823)	2.76629635
85	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.76528178
86	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.76522121
87	negative regulation of erythrocyte differentiation (GO:0045647)	2.75990509
88	fatty acid catabolic process (GO:0009062)	2.73683591
89	motile cilium assembly (GO:0044458)	2.73488609
90	regulation of heart rate by cardiac conduction (GO:0086091)	2.73102432
91	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.72840915
92	vocalization behavior (GO:0071625)	2.72663067
93	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.72271293
94	desmosome organization (GO:0002934)	2.67344137
95	phosphate ion transport (GO:0006817)	2.65691187
96	drug catabolic process (GO:0042737)	2.64485308
97	regulation of cardiac muscle cell contraction (GO:0086004)	2.63030427
98	regulation of extracellular matrix organization (GO:1903053)	2.62817094
99	ketone body metabolic process (GO:1902224)	2.62403518
100	glutamate metabolic process (GO:0006536)	2.62139713
101	acetyl-CoA metabolic process (GO:0006084)	2.61063566
102	carnitine metabolic process (GO:0009437)	2.60810674
103	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.60005321
104	phosphate ion transmembrane transport (GO:0035435)	2.59538573
105	regulation of response to osmotic stress (GO:0047484)	2.59525847
106	dicarboxylic acid catabolic process (GO:0043649)	2.58021479
107	primary alcohol catabolic process (GO:0034310)	2.57969275
108	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.57095099
109	regulation of calcium ion transmembrane transport (GO:1903169)	2.56096842
110	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2.56096842
111	amino-acid betaine metabolic process (GO:0006577)	2.55471879
112	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.55116178
113	axonemal dynein complex assembly (GO:0070286)	2.53672534
114	protein retention in ER lumen (GO:0006621)	2.53617303
115	sodium ion homeostasis (GO:0055078)	2.52619662
116	monocarboxylic acid catabolic process (GO:0072329)	2.51730194
117	striated muscle contraction (GO:0006941)	2.51213639
118	cell volume homeostasis (GO:0006884)	2.49378389
119	exogenous drug catabolic process (GO:0042738)	2.49170967
120	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.48790601
121	glutamate secretion (GO:0014047)	2.48619955
122	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.48603776
123	cardiac muscle cell action potential (GO:0086001)	2.48177720
124	drug transmembrane transport (GO:0006855)	2.47752107
125	positive regulation of potassium ion transport (GO:0043268)	2.46251153
126	L-phenylalanine metabolic process (GO:0006558)	2.44875903
127	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.44875903
128	glyoxylate metabolic process (GO:0046487)	2.44587644
129	regulation of cholesterol homeostasis (GO:2000188)	2.43595538
130	semaphorin-plexin signaling pathway (GO:0071526)	2.43440960
131	one-carbon compound transport (GO:0019755)	2.42704205
132	cell-cell junction maintenance (GO:0045217)	2.41829260
133	L-amino acid import (GO:0043092)	2.39644521
134	positive regulation of protein dephosphorylation (GO:0035307)	2.39374136
135	peptidyl-glutamic acid carboxylation (GO:0017187)	2.38795789
136	protein carboxylation (GO:0018214)	2.38795789
137	myelin maintenance (GO:0043217)	2.38647570
138	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.35110626
139	regulation of synapse maturation (GO:0090128)	2.34306810
140	amino acid import (GO:0043090)	2.32662065
141	central nervous system myelination (GO:0022010)	2.32559130
142	axon ensheathment in central nervous system (GO:0032291)	2.32559130
143	response to parathyroid hormone (GO:0071107)	2.32070486
144	synaptic vesicle exocytosis (GO:0016079)	2.31534262
145	regulation of apoptotic cell clearance (GO:2000425)	2.30759804
146	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.29963239
147	adhesion of symbiont to host (GO:0044406)	2.29697764
148	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.29548061
149	cellular response to reactive nitrogen species (GO:1902170)	2.28263048
150	dopamine receptor signaling pathway (GO:0007212)	2.28159869
151	adherens junction assembly (GO:0034333)	2.23807040
152	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.20817100
153	lung epithelium development (GO:0060428)	2.20534653
154	protein-lipid complex assembly (GO:0065005)	2.19616632
155	surfactant homeostasis (GO:0043129)	2.19554807
156	positive regulation of triglyceride lipase activity (GO:0061365)	2.18595437
157	positive regulation of lipoprotein lipase activity (GO:0051006)	2.18595437
158	multicellular organismal water homeostasis (GO:0050891)	2.17359258
159	positive regulation of glucose import (GO:0046326)	2.17121955
160	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.17108180
161	regulation of cholesterol metabolic process (GO:0090181)	2.16437402
162	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.15975005
163	cellular response to nitric oxide (GO:0071732)	2.15293161
164	endothelial cell chemotaxis (GO:0035767)	2.14955128
165	focal adhesion assembly (GO:0048041)	2.13486114
166	cell-substrate adherens junction assembly (GO:0007045)	2.13486114
167	neuromuscular process controlling balance (GO:0050885)	2.13137975
168	positive regulation of steroid metabolic process (GO:0045940)	2.11127172
169	positive regulation of lipid catabolic process (GO:0050996)	2.11009783
170	cell junction maintenance (GO:0034331)	2.10851230
171	regulation of cholesterol esterification (GO:0010872)	2.10473910
172	actin filament depolymerization (GO:0030042)	2.10321238
173	positive regulation of glucose transport (GO:0010828)	2.08234194
174	regulation of protein dephosphorylation (GO:0035304)	2.07196153
175	regulation of cholesterol biosynthetic process (GO:0045540)	2.06711908
176	regulation of protein activation cascade (GO:2000257)	2.06614051
177	regulation of complement activation (GO:0030449)	2.06487401
178	positive regulation of Rap GTPase activity (GO:0032854)	2.04437028
179	diacylglycerol metabolic process (GO:0046339)	2.04197929
180	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.02674486
181	very-low-density lipoprotein particle assembly (GO:0034379)	2.02653567
182	regulation of ARF GTPase activity (GO:0032312)	2.02539031
183	adhesion of symbiont to host cell (GO:0044650)	2.02478749
184	virion attachment to host cell (GO:0019062)	2.02478749
185	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.01604905
186	activation of MAPKKK activity (GO:0000185)	2.01180943

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.17075864
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.32760712
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.16917566
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.56423421
5	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.55258254
6	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.19499898
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.18705579
8	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.16321872
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.10366205
10	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.03637206
11	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.02540206
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.96975731
13	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.92180395
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.92180395
15	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.88911952
16	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.87692596
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87004714
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.84791193
19	SMC4_20622854_ChIP-Seq_HELA_Human	1.77152316
20	ZNF263_19887448_ChIP-Seq_K562_Human	1.76491562
21	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.75682732
22	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.73344197
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72953426
24	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.72716797
25	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.71994838
26	TCF7_22412390_ChIP-Seq_EML_Mouse	1.69727682
27	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.65177133
28	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.64291258
29	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.63542643
30	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.63188995
31	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.62940021
32	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.58921823
33	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.56025598
34	P68_20966046_ChIP-Seq_HELA_Human	1.54792486
35	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.53337514
36	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.52803457
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.51925776
38	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.49573310
39	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.47096016
40	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.47096016
41	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.46972192
42	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.46827141
43	VDR_21846776_ChIP-Seq_THP-1_Human	1.45090322
44	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43976521
45	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.42089058
46	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.38800654
47	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.38307894
48	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.36518336
49	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.35366593
50	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.34233618
51	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.34075707
52	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.31084304
53	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.29046523
54	KDM2B_26808549_Chip-Seq_K562_Human	1.28968330
55	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.28381307
56	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.27825455
57	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.27230228
58	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.26617827
59	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.26071876
60	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25547553
61	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24950610
62	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24120965
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23992597
64	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.23000950
65	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22689803
66	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.21883744
67	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.20688223
68	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.20685840
69	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.20507638
70	TP63_22573176_ChIP-Seq_HFKS_Human	1.20496948
71	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.18488577
72	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18016674
73	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.17898278
74	MYC_22102868_ChIP-Seq_BL_Human	1.17400846
75	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.16688992
76	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.16442842
77	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.16194919
78	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.15570303
79	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.14890312
80	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13043325
81	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10133573
82	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.09844497
83	LXR_22292898_ChIP-Seq_THP-1_Human	1.09815326
84	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.09434909
85	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.09256602
86	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.08880088
87	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08756829
88	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06659845
89	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.06018033
90	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.05982764
91	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.05127369
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04489909
93	GATA1_19941826_ChIP-Seq_K562_Human	1.04470047
94	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.04117450
95	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.03401197
96	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.02938940
97	CTCF_27219007_Chip-Seq_Bcells_Human	1.01991369
98	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01073759
99	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.01021776
100	SA1_27219007_Chip-Seq_Bcells_Human	1.00904834
101	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.00587313
102	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.99939101
103	RXR_22108803_ChIP-Seq_LS180_Human	0.99295744
104	CLOCK_20551151_ChIP-Seq_293T_Human	0.98307046
105	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.98287488
106	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.98109456
107	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.97794304
108	BCOR_27268052_Chip-Seq_Bcells_Human	0.96705591
109	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96310301
110	OCT4_19829295_ChIP-Seq_ESCs_Human	0.96226695
111	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.95751410
112	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.94967418
113	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.93773197
114	CREB1_26743006_Chip-Seq_LNCaP_Human	0.91308827
115	ZNF274_21170338_ChIP-Seq_K562_Hela	0.90784255
116	EGR1_19032775_ChIP-ChIP_M12_Human	0.90454504
117	KDM2B_26808549_Chip-Seq_DND41_Human	0.90148551
118	AR_21572438_ChIP-Seq_LNCaP_Human	0.89717026
119	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89559522
120	RACK7_27058665_Chip-Seq_MCF-7_Human	0.88885931
121	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.87813329
122	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.87274758
123	KLF4_19829295_ChIP-Seq_ESCs_Human	0.85990299
124	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.85777166
125	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.85538498
126	AR_19668381_ChIP-Seq_PC3_Human	0.83864793
127	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.81591388
128	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.80621710
129	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.79315707
130	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.78315825
131	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.78315825
132	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.78184392
133	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.77686581
134	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.77624183
135	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.77051559
136	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.76259025
137	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.76152788
138	BCAT_22108803_ChIP-Seq_LS180_Human	0.75641833
139	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.75610681
140	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.75598715
141	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.75323637
142	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.74693138
143	SMAD4_21799915_ChIP-Seq_A2780_Human	0.74660713
144	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.73446070
145	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.73277275

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.68640915
2	MP0002837_dystrophic_cardiac_calcinosis	3.36264426
3	MP0004859_abnormal_synaptic_plasticity	3.35281018
4	MP0005409_darkened_coat_color	3.26805164
5	MP0000751_myopathy	3.25181426
6	MP0005360_urolithiasis	3.02371730
7	MP0004130_abnormal_muscle_cell	2.92974520
8	MP0002822_catalepsy	2.80078112
9	MP0004084_abnormal_cardiac_muscle	2.77526013
10	MP0004215_abnormal_myocardial_fiber	2.77152825
11	MP0005058_abnormal_lysosome_morphology	2.71587742
12	MP0002139_abnormal_hepatobiliary_system	2.67669993
13	MP0005085_abnormal_gallbladder_physiolo	2.51470411
14	MP0005330_cardiomyopathy	2.38021104
15	MP0004036_abnormal_muscle_relaxation	2.31918989
16	MP0000678_abnormal_parathyroid_gland	2.28425964
17	MP0003172_abnormal_lysosome_physiology	2.24795649
18	MP0003195_calcinosis	2.19038169
19	MP0005666_abnormal_adipose_tissue	2.07535806
20	MP0009840_abnormal_foam_cell	2.06229345
21	* MP0004043_abnormal_pH_regulation	2.05400050
22	MP0004185_abnormal_adipocyte_glucose	2.04661669
23	MP0004484_altered_response_of	2.03256786
24	MP0008961_abnormal_basal_metabolism	1.94793283
25	MP0004087_abnormal_muscle_fiber	1.94104342
26	MP0009780_abnormal_chondrocyte_physiolo	1.94099095
27	MP0002909_abnormal_adrenal_gland	1.91919404
28	MP0004145_abnormal_muscle_electrophysio	1.86590858
29	MP0000749_muscle_degeneration	1.86012745
30	MP0008775_abnormal_heart_ventricle	1.85209521
31	MP0005332_abnormal_amino_acid	1.84398070
32	MP0002972_abnormal_cardiac_muscle	1.79960654
33	MP0005620_abnormal_muscle_contractility	1.79859617
34	MP0002089_abnormal_postnatal_growth/wei	1.77159697
35	MP0003635_abnormal_synaptic_transmissio	1.76743181
36	MP0005365_abnormal_bile_salt	1.73281129
37	MP0003137_abnormal_impulse_conducting	1.72282810
38	MP0003252_abnormal_bile_duct	1.69984436
39	MP0002249_abnormal_larynx_morphology	1.69311844
40	* MP0006036_abnormal_mitochondrial_physio	1.60653904
41	MP0002877_abnormal_melanocyte_morpholog	1.54465785
42	MP0000747_muscle_weakness	1.53872062
43	MP0005535_abnormal_body_temperature	1.50900202
44	MP0003123_paternal_imprinting	1.50701653
45	MP0001502_abnormal_circadian_rhythm	1.48793837
46	MP0004270_analgesia	1.48652065
47	MP0008875_abnormal_xenobiotic_pharmacok	1.48179528
48	MP0005375_adipose_tissue_phenotype	1.46851773
49	MP0005670_abnormal_white_adipose	1.45364113
50	MP0005385_cardiovascular_system_phenoty	1.43642999
51	MP0001544_abnormal_cardiovascular_syste	1.43642999
52	MP0005451_abnormal_body_composition	1.41412260
53	MP0002106_abnormal_muscle_physiology	1.41138885
54	MP0002971_abnormal_brown_adipose	1.40340904
55	MP0003183_abnormal_peptide_metabolism	1.39776224
56	MP0002796_impaired_skin_barrier	1.39734380
57	MP0004085_abnormal_heartbeat	1.39546548
58	MP0000750_abnormal_muscle_regeneration	1.38577827
59	MP0003453_abnormal_keratinocyte_physiol	1.36537025
60	MP0009745_abnormal_behavioral_response	1.35868354
61	MP0001765_abnormal_ion_homeostasis	1.34344126
62	MP0006138_congestive_heart_failure	1.34021368
63	MP0010329_abnormal_lipoprotein_level	1.33263597
64	MP0010630_abnormal_cardiac_muscle	1.33228047
65	MP0009115_abnormal_fat_cell	1.30718429
66	MP0005076_abnormal_cell_differentiation	1.28559614
67	MP0002118_abnormal_lipid_homeostasis	1.26379159
68	MP0002269_muscular_atrophy	1.23086494
69	MP0000604_amyloidosis	1.21043992
70	MP0005167_abnormal_blood-brain_barrier	1.20022431
71	MP0002063_abnormal_learning/memory/cond	1.19809105
72	MP0000013_abnormal_adipose_tissue	1.19135561
73	MP0005584_abnormal_enzyme/coenzyme_acti	1.18822305
74	MP0010234_abnormal_vibrissa_follicle	1.18007752
75	MP0002876_abnormal_thyroid_physiology	1.17146637
76	MP0002064_seizures	1.15986853
77	MP0005369_muscle_phenotype	1.15519984
78	MP0000920_abnormal_myelination	1.12202258
79	MP0003221_abnormal_cardiomyocyte_apopto	1.11871764
80	MP0000759_abnormal_skeletal_muscle	1.11780435
81	MP0009643_abnormal_urine_homeostasis	1.11013940
82	MP0009046_muscle_twitch	1.10189774
83	MP0002078_abnormal_glucose_homeostasis	1.09909780
84	MP0003868_abnormal_feces_composition	1.08902058
85	MP0003283_abnormal_digestive_organ	1.07654424
86	MP0004233_abnormal_muscle_weight	1.07589345
87	MP0005423_abnormal_somatic_nervous	1.07359934
88	MP0004510_myositis	1.07237254
89	MP0003879_abnormal_hair_cell	1.06409278
90	MP0008569_lethality_at_weaning	1.05925879
91	MP0001486_abnormal_startle_reflex	1.05347951
92	MP0003300_gastrointestinal_ulcer	1.05013961
93	MP0004019_abnormal_vitamin_homeostasis	1.03436838
94	MP0000230_abnormal_systemic_arterial	1.02363970
95	MP0002138_abnormal_hepatobiliary_system	1.01944377
96	MP0005166_decreased_susceptibility_to	1.01744833
97	MP0003634_abnormal_glial_cell	1.00545337
98	MP0004885_abnormal_endolymph	0.99791342
99	MP0004782_abnormal_surfactant_physiolog	0.99624770
100	MP0005503_abnormal_tendon_morphology	0.98067361
101	MP0000681_abnormal_thyroid_gland	0.96437359
102	MP0001849_ear_inflammation	0.95083042
103	MP0003880_abnormal_central_pattern	0.94594767
104	MP0001501_abnormal_sleep_pattern	0.93691380
105	MP0000003_abnormal_adipose_tissue	0.93291638
106	MP0003329_amyloid_beta_deposits	0.92800845
107	MP0003279_aneurysm	0.89512083
108	MP0003690_abnormal_glial_cell	0.87973501
109	MP0001756_abnormal_urination	0.87906464
110	MP0004264_abnormal_extraembryonic_tissu	0.87209599
111	MP0003705_abnormal_hypodermis_morpholog	0.87138622
112	MP0005319_abnormal_enzyme/_coenzyme	0.86572534
113	MP0001958_emphysema	0.85897236
114	MP0003828_pulmonary_edema	0.85782689
115	MP0002970_abnormal_white_adipose	0.85587436
116	MP0003075_altered_response_to	0.85249468
117	MP0001346_abnormal_lacrimal_gland	0.85144232
118	MP0005165_increased_susceptibility_to	0.84842201
119	MP0002896_abnormal_bone_mineralization	0.84276396
120	MP0003303_peritoneal_inflammation	0.83972982
121	MP0002272_abnormal_nervous_system	0.83617679
122	MP0003633_abnormal_nervous_system	0.83516238
123	MP0001440_abnormal_grooming_behavior	0.83421049
124	MP0005623_abnormal_meninges_morphology	0.82293709
125	MP0002734_abnormal_mechanical_nocicepti	0.81900937
126	MP0003045_fibrosis	0.80837168
127	MP0001666_abnormal_nutrient_absorption	0.80552803
128	MP0005083_abnormal_biliary_tract	0.79330916
129	MP0004858_abnormal_nervous_system	0.79193850
130	MP0001348_abnormal_lacrimal_gland	0.78496063
131	MP0005386_behavior/neurological_phenoty	0.77508059
132	MP0004924_abnormal_behavior	0.77508059
133	MP0008874_decreased_physiological_sensi	0.77353004
134	MP0005448_abnormal_energy_balance	0.76471607
135	MP0003878_abnormal_ear_physiology	0.76198747
136	MP0005377_hearing/vestibular/ear_phenot	0.76198747
137	MP0000566_synostosis	0.73842495
138	MP0002332_abnormal_exercise_endurance	0.73680730
139	MP0002572_abnormal_emotion/affect_behav	0.73577107
140	MP0005501_abnormal_skin_physiology	0.73273099
141	MP0009379_abnormal_foot_pigmentation	0.72843140
142	MP0005187_abnormal_penis_morphology	0.72689310
143	MP0005646_abnormal_pituitary_gland	0.72641632
144	MP0003566_abnormal_cell_adhesion	0.71020064
145	MP0002108_abnormal_muscle_morphology	0.70442498
146	MP0000733_abnormal_muscle_development	0.68202073
147	MP0001664_abnormal_digestion	0.67743908

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	4.80691634
2	Sudden death (HP:0001699)	4.54831198
3	Ventricular fibrillation (HP:0001663)	4.39810927
4	Exercise-induced myalgia (HP:0003738)	4.10906589
5	Bundle branch block (HP:0011710)	4.08012024
6	Myoglobinuria (HP:0002913)	3.89167955
7	Ketoacidosis (HP:0001993)	3.66234427
8	Exercise-induced muscle cramps (HP:0003710)	3.64897527
9	Hypoglycemic coma (HP:0001325)	3.57357303
10	Atrial fibrillation (HP:0005110)	3.48332542
11	Syncope (HP:0001279)	3.37979574
12	Gout (HP:0001997)	3.36129685
13	Hyperglycinuria (HP:0003108)	3.34808243
14	Primary atrial arrhythmia (HP:0001692)	3.29368304
15	Calf muscle hypertrophy (HP:0008981)	3.27589387
16	Ventricular tachycardia (HP:0004756)	3.26126255
17	Ketosis (HP:0001946)	3.25713210
18	Prolonged QT interval (HP:0001657)	3.23829684
19	Heart block (HP:0012722)	3.16115103
20	Myokymia (HP:0002411)	3.10536344
21	Complement deficiency (HP:0004431)	3.08115755
22	Neurofibrillary tangles (HP:0002185)	3.07591619
23	Supraventricular tachycardia (HP:0004755)	3.06293283
24	Muscle hypertrophy of the lower extremities (HP:0008968)	3.06218947
25	Systemic lupus erythematosus (HP:0002725)	3.04244479
26	Ventricular arrhythmia (HP:0004308)	3.01950173
27	Right ventricular cardiomyopathy (HP:0011663)	2.99893307
28	Atrioventricular block (HP:0001678)	2.99154830
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.99024433
30	Supraventricular arrhythmia (HP:0005115)	2.98961511
31	Abnormal atrioventricular conduction (HP:0005150)	2.98639494
32	Abnormality of glycine metabolism (HP:0010895)	2.95396774
33	Abnormality of serine family amino acid metabolism (HP:0010894)	2.95396774
34	Muscle fiber splitting (HP:0003555)	2.92287817
35	Hyporeflexia of lower limbs (HP:0002600)	2.81952148
36	Nonprogressive disorder (HP:0003680)	2.79648890
37	Increased circulating renin level (HP:0000848)	2.78644531
38	Nasal polyposis (HP:0100582)	2.78509182
39	Hyperammonemia (HP:0001987)	2.78324568
40	Abnormality of the nasal mucosa (HP:0000433)	2.77830250
41	Abnormality of fatty-acid metabolism (HP:0004359)	2.75124976
42	Abnormality of the calf musculature (HP:0001430)	2.73112954
43	Atelectasis (HP:0100750)	2.69715432
44	Asymmetric septal hypertrophy (HP:0001670)	2.68891907
45	Distal lower limb muscle weakness (HP:0009053)	2.67739424
46	Metabolic alkalosis (HP:0200114)	2.65861377
47	Abnormal EKG (HP:0003115)	2.65818311
48	Difficulty running (HP:0009046)	2.64608587
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.63087761
50	Absent/shortened dynein arms (HP:0200106)	2.63087761
51	Hyperglycinemia (HP:0002154)	2.60259235
52	Cerebral inclusion bodies (HP:0100314)	2.58266495
53	Abnormality of complement system (HP:0005339)	2.57598308
54	Focal motor seizures (HP:0011153)	2.56920149
55	Abnormality of the left ventricular outflow tract (HP:0011103)	2.55870074
56	Subaortic stenosis (HP:0001682)	2.55870074
57	Glomerulonephritis (HP:0000099)	2.55337118
58	Palpitations (HP:0001962)	2.53931481
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.49834608
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.49834608
61	Supranuclear gaze palsy (HP:0000605)	2.48993044
62	Abnormal respiratory motile cilium physiology (HP:0012261)	2.48676242
63	Hypokalemic alkalosis (HP:0001949)	2.47359422
64	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.47275832
65	Dicarboxylic aciduria (HP:0003215)	2.46207277
66	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.46207277
67	Abnormal ciliary motility (HP:0012262)	2.45260118
68	Increased purine levels (HP:0004368)	2.43922579
69	Hyperuricemia (HP:0002149)	2.43922579
70	Hypercortisolism (HP:0001578)	2.43540815
71	Proximal tubulopathy (HP:0000114)	2.40431552
72	Hyperacusis (HP:0010780)	2.35952800
73	Hyperparathyroidism (HP:0000843)	2.35599346
74	Rhabdomyolysis (HP:0003201)	2.32962497
75	Hemorrhage of the eye (HP:0011885)	2.32604306
76	Lipoatrophy (HP:0100578)	2.31270327
77	Generalized aminoaciduria (HP:0002909)	2.30165300
78	Abnormality of chloride homeostasis (HP:0011422)	2.30069210
79	Visual hallucinations (HP:0002367)	2.29473364
80	Action tremor (HP:0002345)	2.28843449
81	Dysmetric saccades (HP:0000641)	2.27299739
82	Abnormality of binocular vision (HP:0011514)	2.24698082
83	Diplopia (HP:0000651)	2.24698082
84	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.22228122
85	Hyperactive renin-angiotensin system (HP:0000841)	2.21044813
86	Hyperthyroidism (HP:0000836)	2.20977453
87	Hyperphosphatemia (HP:0002905)	2.19654864
88	Xanthomatosis (HP:0000991)	2.19498303
89	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.17305817
90	Truncus arteriosus (HP:0001660)	2.16702411
91	Delayed CNS myelination (HP:0002188)	2.16561618
92	EMG: myopathic abnormalities (HP:0003458)	2.16467014
93	Muscle stiffness (HP:0003552)	2.15261474
94	Protrusio acetabuli (HP:0003179)	2.14123167
95	Upper limb amyotrophy (HP:0009129)	2.13909646
96	Distal upper limb amyotrophy (HP:0007149)	2.13909646
97	Dilated cardiomyopathy (HP:0001644)	2.13890082
98	Impaired social interactions (HP:0000735)	2.13449123
99	Abnormal social behavior (HP:0012433)	2.13449123
100	Abnormality of purine metabolism (HP:0004352)	2.12775093
101	Papilledema (HP:0001085)	2.10430206
102	Chronic bronchitis (HP:0004469)	2.09523826
103	Ankle clonus (HP:0011448)	2.08807554
104	Abnormality of renin-angiotensin system (HP:0000847)	2.06751523
105	Myopathic facies (HP:0002058)	2.05575133
106	Male infertility (HP:0003251)	2.04930284
107	Metabolic acidosis (HP:0001942)	2.04487279
108	Hyperinsulinemic hypoglycemia (HP:0000825)	2.04249203
109	Anxiety (HP:0000739)	2.03967924
110	Rhinitis (HP:0012384)	2.03635576
111	Hyperaldosteronism (HP:0000859)	2.03219540
112	Axonal loss (HP:0003447)	2.01322212
113	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.00871755
114	Late onset (HP:0003584)	2.00176104
115	Myotonia (HP:0002486)	2.00153370
116	Adrenal overactivity (HP:0002717)	1.99817757
117	Hyperkalemia (HP:0002153)	1.98875789
118	Poor eye contact (HP:0000817)	1.97890906
119	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.97889088
120	Abnormality of the Achilles tendon (HP:0005109)	1.97849260
121	Dysdiadochokinesis (HP:0002075)	1.97520425
122	Foot dorsiflexor weakness (HP:0009027)	1.97119563
123	Cerebral aneurysm (HP:0004944)	1.96533149
124	Hypoalphalipoproteinemia (HP:0003233)	1.95245941
125	Flat acetabular roof (HP:0003180)	1.93608538
126	Increased connective tissue (HP:0009025)	1.93534847
127	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.93104215
128	Polycythemia (HP:0001901)	1.92763319
129	Purpura (HP:0000979)	1.91251661
130	Hyperglycemia (HP:0003074)	1.90768477
131	Nausea (HP:0002018)	1.89997890
132	Malnutrition (HP:0004395)	1.87619407
133	Conjunctival hamartoma (HP:0100780)	1.87255960
134	Vascular calcification (HP:0004934)	1.86979636
135	Increased variability in muscle fiber diameter (HP:0003557)	1.86199382
136	Neonatal onset (HP:0003623)	1.86152230
137	Focal seizures (HP:0007359)	1.85918877
138	Bronchomalacia (HP:0002780)	1.85042587
139	Nuclear cataract (HP:0100018)	1.83174174
140	Neuronal loss in central nervous system (HP:0002529)	1.82288004
141	Status epilepticus (HP:0002133)	1.81934378
142	Depression (HP:0000716)	1.81862692
143	Bowel incontinence (HP:0002607)	1.81713795
144	Achilles tendon contracture (HP:0001771)	1.81525741
145	Abnormality of potassium homeostasis (HP:0011042)	1.81140481
146	Hepatic necrosis (HP:0002605)	1.80964867
147	Postural instability (HP:0002172)	1.80812965
148	Cerebral edema (HP:0002181)	1.80000318
149	Dysostosis multiplex (HP:0000943)	1.79985989
150	Deep venous thrombosis (HP:0002625)	1.79470861
151	Lymphangioma (HP:0100764)	1.79382232
152	Pheochromocytoma (HP:0002666)	1.79372769
153	Increased muscle lipid content (HP:0009058)	1.79176955
154	Sudden cardiac death (HP:0001645)	1.78270427
155	Abnormality of the foot musculature (HP:0001436)	1.78008650
156	Hypophosphatemia (HP:0002148)	1.77077333
157	Stridor (HP:0010307)	1.75607668
158	Bell-shaped thorax (HP:0001591)	1.74375027
159	Increased cerebral lipofuscin (HP:0011813)	1.73398296
160	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.71412368
161	Abnormality of the thoracic spine (HP:0100711)	1.70406551
162	Insomnia (HP:0100785)	1.69666145
163	Recurrent otitis media (HP:0000403)	1.69279497
164	Sleep apnea (HP:0010535)	1.68954647
165	Urinary glycosaminoglycan excretion (HP:0003541)	1.68706830
166	Mucopolysacchariduria (HP:0008155)	1.68706830
167	Pseudobulbar signs (HP:0002200)	1.67827803
168	Rigidity (HP:0002063)	1.67116099
169	Shallow orbits (HP:0000586)	1.65500550
170	Turricephaly (HP:0000262)	1.64956363
171	J-shaped sella turcica (HP:0002680)	1.63674355
172	Hypotension (HP:0002615)	1.62558705
173	EMG: neuropathic changes (HP:0003445)	1.62550424
174	Peripheral hypomyelination (HP:0007182)	1.61917978

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	3.52946921
2	CDK12	3.24692638
3	LMTK2	3.01658999
4	WNK4	2.78339283
5	PRKD3	2.54588688
6	PKN2	2.52589888
7	PRPF4B	2.49953472
8	STK38	2.45922116
9	ERN1	2.41955232
10	EPHA4	2.32502895
11	PDK3	2.30077285
12	PDK4	2.30077285
13	PHKG2	2.29148217
14	PHKG1	2.29148217
15	MAP3K9	2.19116188
16	PINK1	2.17474017
17	ICK	2.13091014
18	TTN	2.06326381
19	NEK1	2.06269786
20	EEF2K	1.97799535
21	DMPK	1.97306803
22	DAPK2	1.96310706
23	FGFR4	1.95428162
24	NTRK3	1.94332650
25	MAPK15	1.87188188
26	BCKDK	1.85732618
27	KSR2	1.83382874
28	RIPK1	1.78689656
29	MAPKAPK3	1.77097261
30	TAOK1	1.73018350
31	CAMKK1	1.72660012
32	PAK6	1.60756414
33	MAP2K4	1.58088367
34	SIK2	1.54389935
35	MARK2	1.46422799
36	WNK1	1.44819031
37	STK39	1.41422623
38	SMG1	1.39214031
39	MINK1	1.34186452
40	OXSR1	1.32356046
41	PDK2	1.27360290
42	MAP3K4	1.23422818
43	PAK3	1.22359780
44	ALK	1.14257368
45	MAP3K2	1.13067382
46	FGFR3	1.12408946
47	TESK1	1.12131332
48	MAP3K7	1.10708435
49	STK11	1.09023341
50	OBSCN	1.08743006
51	TNK2	1.07006858
52	PDPK1	1.06852660
53	WNK3	1.05405013
54	CAMK1	1.00927805
55	PIK3CA	0.99791563
56	PRKCH	0.99558118
57	MTOR	0.97847011
58	EPHA2	0.97498299
59	CDC42BPA	0.96929689
60	RET	0.94832291
61	MAP3K1	0.94711273
62	HIPK2	0.94186386
63	LATS2	0.93201440
64	EPHB1	0.92136968
65	PDK1	0.91637990
66	CAMK1G	0.89159812
67	PTK2	0.87998981
68	PRKD1	0.87058070
69	NTRK1	0.84321739
70	FER	0.83968560
71	CAMK2D	0.78607179
72	MAP3K3	0.78525264
73	NEK9	0.78088431
74	CAMK4	0.76444095
75	PRKAA2	0.76105924
76	STK24	0.76073642
77	MARK1	0.75197531
78	PDGFRA	0.74966783
79	SGK3	0.73272762
80	INSRR	0.72362329
81	MST1R	0.72006644
82	CAMK1D	0.71977350
83	CDK5	0.71149077
84	MYLK	0.69340960
85	MAPK11	0.68172543
86	TIE1	0.67111090
87	PRKAA1	0.67054023
88	MAPK10	0.66876733
89	PDGFRB	0.66290370
90	PRKD2	0.66158452
91	ARAF	0.65823306
92	FES	0.65108547
93	CAMK2G	0.64977748
94	CAMK2A	0.64642060
95	MAP3K6	0.64594378
96	MAP2K2	0.64474502
97	SGK1	0.62607258
98	RPS6KA2	0.61332355
99	MAPK7	0.60631589
100	FRK	0.59873197
101	SGK223	0.59575643
102	SGK494	0.59575643
103	STK38L	0.58490272
104	MAP3K10	0.58110097
105	MAP3K13	0.56393665
106	TYRO3	0.55796560
107	MAP3K11	0.54831728
108	BRD4	0.54673080
109	CAMKK2	0.54125698
110	TRPM7	0.53880217
111	MUSK	0.53418194
112	DDR2	0.53035244
113	RIPK4	0.52559702
114	MAP2K7	0.52524676
115	JAK2	0.52092879
116	TAOK2	0.51423093
117	PRKACG	0.51106617
118	RPS6KA3	0.49855581
119	PTK6	0.49116172
120	ZAP70	0.47956272
121	BMX	0.46606581
122	UHMK1	0.46561643
123	ROCK1	0.46245448
124	PRKG2	0.44960079
125	DAPK3	0.44713354
126	ABL2	0.43367768
127	NEK6	0.41573256
128	CAMK2B	0.41261916
129	NTRK2	0.41188541
130	TYK2	0.39869431
131	JAK1	0.39473402
132	TBK1	0.39386955
133	MAP2K6	0.39128950
134	PRKCG	0.39022241
135	MAPK4	0.38684734
136	SGK2	0.38485373
137	MAP3K5	0.36605451
138	MAPK12	0.36517517
139	PTK2B	0.35645145
140	MAP2K1	0.34702759
141	SIK1	0.33971520
142	PRKCZ	0.33420039

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.32957851
2	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.12419892
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.71296920
4	Propanoate metabolism_Homo sapiens_hsa00640	2.67603565
5	Fatty acid degradation_Homo sapiens_hsa00071	2.51784648
6	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.46709168
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.32238664
8	Butanoate metabolism_Homo sapiens_hsa00650	2.22361525
9	Histidine metabolism_Homo sapiens_hsa00340	2.21134390
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.05131471
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.02240607
12	Fatty acid metabolism_Homo sapiens_hsa01212	1.88228737
13	Arginine biosynthesis_Homo sapiens_hsa00220	1.86699943
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79809969
15	Other glycan degradation_Homo sapiens_hsa00511	1.78919443
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.54770230
17	Carbon metabolism_Homo sapiens_hsa01200	1.51002200
18	Bile secretion_Homo sapiens_hsa04976	1.47860356
19	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.46358313
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.43341367
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39341093
22	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.37123480
23	Complement and coagulation cascades_Homo sapiens_hsa04610	1.36496419
24	Prion diseases_Homo sapiens_hsa05020	1.36042320
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.35665488
26	Gastric acid secretion_Homo sapiens_hsa04971	1.30664915
27	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.29100519
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29040665
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.27083830
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.23468031
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23376307
32	VEGF signaling pathway_Homo sapiens_hsa04370	1.18473564
33	Insulin secretion_Homo sapiens_hsa04911	1.18311251
34	Olfactory transduction_Homo sapiens_hsa04740	1.15269013
35	Tyrosine metabolism_Homo sapiens_hsa00350	1.14888342
36	Notch signaling pathway_Homo sapiens_hsa04330	1.11971105
37	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.11400711
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.10467456
39	GABAergic synapse_Homo sapiens_hsa04727	1.04332636
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.01167965
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00771404
42	Circadian entrainment_Homo sapiens_hsa04713	0.99867846
43	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.97892469
44	Salivary secretion_Homo sapiens_hsa04970	0.97861668
45	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.97755238
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96517521
47	Type II diabetes mellitus_Homo sapiens_hsa04930	0.96292681
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.95327389
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93912096
50	Long-term potentiation_Homo sapiens_hsa04720	0.93570350
51	Choline metabolism in cancer_Homo sapiens_hsa05231	0.92911109
52	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.90527342
53	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.89541244
54	Glucagon signaling pathway_Homo sapiens_hsa04922	0.89198067
55	Peroxisome_Homo sapiens_hsa04146	0.88205926
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.86584428
57	Morphine addiction_Homo sapiens_hsa05032	0.86571235
58	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.86067479
59	Cholinergic synapse_Homo sapiens_hsa04725	0.85260736
60	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.84420132
61	Parkinsons disease_Homo sapiens_hsa05012	0.83520733
62	mTOR signaling pathway_Homo sapiens_hsa04150	0.83349405
63	Insulin resistance_Homo sapiens_hsa04931	0.82080769
64	Lysine degradation_Homo sapiens_hsa00310	0.81809419
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81736806
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.81693084
67	Amphetamine addiction_Homo sapiens_hsa05031	0.80682194
68	Renal cell carcinoma_Homo sapiens_hsa05211	0.80665810
69	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.80582087
70	Renin secretion_Homo sapiens_hsa04924	0.80143818
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.79756427
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78870087
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78262637
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77323845
75	Mineral absorption_Homo sapiens_hsa04978	0.76277828
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.75961843
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.75520249
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.74855160
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.74780844
80	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.73906839
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71588038
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.71512059
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.71209243
84	Retinol metabolism_Homo sapiens_hsa00830	0.70388917
85	Alzheimers disease_Homo sapiens_hsa05010	0.70051848
86	Amoebiasis_Homo sapiens_hsa05146	0.70028064
87	Nicotine addiction_Homo sapiens_hsa05033	0.68844407
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68819656
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68550882
90	Oxidative phosphorylation_Homo sapiens_hsa00190	0.68472755
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68409742
92	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.67546061
93	Sulfur metabolism_Homo sapiens_hsa00920	0.66376693
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.66333284
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.66144325
96	Lysosome_Homo sapiens_hsa04142	0.66057552
97	Acute myeloid leukemia_Homo sapiens_hsa05221	0.65562123
98	GnRH signaling pathway_Homo sapiens_hsa04912	0.63861084
99	Pancreatic secretion_Homo sapiens_hsa04972	0.63468294
100	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.62692205
101	Tight junction_Homo sapiens_hsa04530	0.62645591
102	AMPK signaling pathway_Homo sapiens_hsa04152	0.62604451
103	ABC transporters_Homo sapiens_hsa02010	0.62106592
104	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.61649221
105	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.60487085
106	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.59001615
107	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.58810920
108	Fat digestion and absorption_Homo sapiens_hsa04975	0.58480321
109	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58037047
110	Non-small cell lung cancer_Homo sapiens_hsa05223	0.57749649
111	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56951257
112	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56333960
113	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.56178188
114	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56093600
115	Endometrial cancer_Homo sapiens_hsa05213	0.55742399
116	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55031974
117	Cocaine addiction_Homo sapiens_hsa05030	0.54864665
118	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.54648660
119	Phenylalanine metabolism_Homo sapiens_hsa00360	0.54403420
120	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.53294060
121	Sulfur relay system_Homo sapiens_hsa04122	0.52130287
122	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51202347
123	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.50644165
124	Glioma_Homo sapiens_hsa05214	0.49640005
125	Endocytosis_Homo sapiens_hsa04144	0.49063899
126	Taste transduction_Homo sapiens_hsa04742	0.47071429
127	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46903214
128	Fatty acid elongation_Homo sapiens_hsa00062	0.46450703
129	Gap junction_Homo sapiens_hsa04540	0.44730085
130	Estrogen signaling pathway_Homo sapiens_hsa04915	0.43103876
131	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40821099
132	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40517650
133	Long-term depression_Homo sapiens_hsa04730	0.38675686
134	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38044728
135	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37149069
136	Melanogenesis_Homo sapiens_hsa04916	0.34928311
137	Protein digestion and absorption_Homo sapiens_hsa04974	0.34489434
138	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31686362
139	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30537934
140	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.29934293

MT-ND6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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