ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* cellular response to cadmium ion (GO:0071276)	7.04997650
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.57909008
3	L-phenylalanine metabolic process (GO:0006558)	4.57909008
4	regulation of metalloenzyme activity (GO:0048552)	4.47061388
5	hemidesmosome assembly (GO:0031581)	4.19890569
6	* response to zinc ion (GO:0010043)	4.15712248
7	fibrinolysis (GO:0042730)	4.15065615
8	L-phenylalanine catabolic process (GO:0006559)	3.96438303
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.96438303
10	epoxygenase P450 pathway (GO:0019373)	3.93187721
11	regulation of plasminogen activation (GO:0010755)	3.92391680
12	negative regulation of lipase activity (GO:0060192)	3.88816804
13	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.86109327
14	cellular copper ion homeostasis (GO:0006878)	3.80149507
15	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	3.75918925
16	desmosome organization (GO:0002934)	3.75523039
17	nucleotide-sugar biosynthetic process (GO:0009226)	3.74393535
18	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.57588509
19	protein carboxylation (GO:0018214)	3.56446801
20	peptidyl-glutamic acid carboxylation (GO:0017187)	3.56446801
21	skin morphogenesis (GO:0043589)	3.47905284
22	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.45856830
23	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.44929853
24	nucleobase-containing small molecule interconversion (GO:0015949)	3.44753300
25	cell adhesion mediated by integrin (GO:0033627)	3.44188293
26	urea metabolic process (GO:0019627)	3.42150221
27	membrane raft organization (GO:0031579)	3.41658952
28	negative regulation of fibrinolysis (GO:0051918)	3.41350895
29	regulation of fibrinolysis (GO:0051917)	3.36796764
30	complement activation, alternative pathway (GO:0006957)	3.35444186
31	omega-hydroxylase P450 pathway (GO:0097267)	3.32143213
32	urea cycle (GO:0000050)	3.28978059
33	* response to cadmium ion (GO:0046686)	3.28699842
34	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.24160893
35	barbed-end actin filament capping (GO:0051016)	3.14720228
36	nitrogen cycle metabolic process (GO:0071941)	3.05846118
37	negative regulation of coagulation (GO:0050819)	3.03441410
38	ethanol oxidation (GO:0006069)	3.02780969
39	GDP-mannose metabolic process (GO:0019673)	3.00168938
40	positive regulation of triglyceride lipase activity (GO:0061365)	2.98848998
41	positive regulation of lipoprotein lipase activity (GO:0051006)	2.98848998
42	drug metabolic process (GO:0017144)	2.97089683
43	glutamine family amino acid biosynthetic process (GO:0009084)	2.95878193
44	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.93360853
45	acute-phase response (GO:0006953)	2.92345089
46	protein retention in ER lumen (GO:0006621)	2.90210022
47	copper ion homeostasis (GO:0055070)	2.89426716
48	COPII vesicle coating (GO:0048208)	2.88780710
49	lung vasculature development (GO:0060426)	2.88303528
50	regulation of protein activation cascade (GO:2000257)	2.87317620
51	negative regulation of blood coagulation (GO:0030195)	2.86412993
52	negative regulation of hemostasis (GO:1900047)	2.86412993
53	protein localization to endosome (GO:0036010)	2.84735495
54	adhesion of symbiont to host cell (GO:0044650)	2.83619224
55	virion attachment to host cell (GO:0019062)	2.83619224
56	triglyceride homeostasis (GO:0070328)	2.83033801
57	acylglycerol homeostasis (GO:0055090)	2.83033801
58	regulation of complement activation (GO:0030449)	2.82746969
59	positive regulation of extracellular matrix organization (GO:1903055)	2.75843517
60	protein maturation by protein folding (GO:0022417)	2.71284234
61	adhesion of symbiont to host (GO:0044406)	2.69801532
62	exogenous drug catabolic process (GO:0042738)	2.69146877
63	drug catabolic process (GO:0042737)	2.68245664
64	regulation of vitamin metabolic process (GO:0030656)	2.66527210
65	negative regulation of wound healing (GO:0061045)	2.66510200
66	regulation of integrin-mediated signaling pathway (GO:2001044)	2.65577471
67	COPI coating of Golgi vesicle (GO:0048205)	2.65400378
68	Golgi transport vesicle coating (GO:0048200)	2.65400378
69	cellular zinc ion homeostasis (GO:0006882)	2.62264926
70	negative regulation of response to reactive oxygen species (GO:1901032)	2.59994190
71	L-ascorbic acid metabolic process (GO:0019852)	2.56719718
72	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.56333639
73	protein hydroxylation (GO:0018126)	2.54393826
74	opsonization (GO:0008228)	2.54341798
75	cell-substrate junction assembly (GO:0007044)	2.54326499
76	nucleoside diphosphate biosynthetic process (GO:0009133)	2.53562025
77	actin filament depolymerization (GO:0030042)	2.53360680
78	cellular glucuronidation (GO:0052695)	2.53036197
79	ethanol metabolic process (GO:0006067)	2.52851424
80	positive regulation of wound healing (GO:0090303)	2.51023666
81	NADH metabolic process (GO:0006734)	2.50843955
82	regulation of cholesterol homeostasis (GO:2000188)	2.50526822
83	regulation of triglyceride catabolic process (GO:0010896)	2.50273789
84	type B pancreatic cell proliferation (GO:0044342)	2.48156554
85	keratinocyte proliferation (GO:0043616)	2.47683364
86	fructose metabolic process (GO:0006000)	2.46594115
87	coenzyme catabolic process (GO:0009109)	2.46089058
88	positive regulation of pseudopodium assembly (GO:0031274)	2.45403115
89	renal system process involved in regulation of blood volume (GO:0001977)	2.44342011
90	* response to transition metal nanoparticle (GO:1990267)	2.44028215
91	cofactor catabolic process (GO:0051187)	2.41165758
92	response to copper ion (GO:0046688)	2.40759800
93	negative regulation of anoikis (GO:2000811)	2.38281369
94	regulation of membrane protein ectodomain proteolysis (GO:0051043)	2.37691599
95	regulation of epidermal growth factor-activated receptor activity (GO:0007176)	2.37551964
96	bile acid and bile salt transport (GO:0015721)	2.36748405
97	uronic acid metabolic process (GO:0006063)	2.36241627
98	glucuronate metabolic process (GO:0019585)	2.36241627
99	peptidyl-proline hydroxylation (GO:0019511)	2.36090472
100	* cellular response to zinc ion (GO:0071294)	12.0432949

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	6.29365485
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.39952697
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.23871138
4	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.72256248
5	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.56551855
6	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.55000916
7	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.30881912
8	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.97075608
9	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.86855772
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.50924891
11	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.40385898
12	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.25098557
13	CLOCK_20551151_ChIP-Seq_293T_Human	2.22619830
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.22549658
15	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.20947355
16	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.17238352
17	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.11407405
18	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.11407405
19	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.11077581
20	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	2.11053641
21	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.00009321
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.97984370
23	ZNF263_19887448_ChIP-Seq_K562_Human	1.97248509
24	* ATF3_27146783_Chip-Seq_COLON_Human	1.96595755
25	AR_21909140_ChIP-Seq_LNCAP_Human	1.96554069
26	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.91990570
27	SOX2_20726797_ChIP-Seq_SW620_Human	1.86285332
28	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.82616123
29	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.82112338
30	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.78984333
31	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.78893870
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.78512268
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.76334527
34	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.72154508
35	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.71984618
36	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.71761037
37	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.68908375
38	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.68197603
39	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.62462842
40	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.60262405
41	CJUN_26792858_Chip-Seq_BT549_Human	1.59777600
42	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.59158003
43	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.57622755
44	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.54790794
45	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.52726952
46	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51816242
47	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.50780019
48	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.45570710
49	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.43123303
50	LXR_22292898_ChIP-Seq_THP-1_Human	1.39848354
51	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.37074776
52	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.36073149
53	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.35022593
54	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.34960454
55	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.32706182
56	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.31914613
57	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.31801764
58	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.30295811
59	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.29953940
60	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.26583557
61	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.26169577
62	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25831998
63	BRD4_25478319_ChIP-Seq_HGPS_Human	1.23428272
64	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.19294901
65	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.18365925
66	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.18093922
67	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.17123018
68	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.16325032
69	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.10156645
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.09612754
71	GATA4_25053715_ChIP-Seq_YYC3_Human	1.07167154
72	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.05262334
73	GATA6_25053715_ChIP-Seq_YYC3_Human	1.02250295
74	TP53_22127205_ChIP-Seq_IMR90_Human	1.01592469
75	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.98199150
76	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.96614599
77	* CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.95298078
78	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.95158262
79	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.93844851
80	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.92128625
81	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.92128625
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91780049
83	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.91314608
84	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.90825748
85	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.89830879
86	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.88313562
87	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87896274
88	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.85571378
89	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.85501925
90	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85084046
91	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.84365960
92	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.83424640
93	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.83166149
94	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.83117556
95	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.82470299
96	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.82147198
97	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.82112322
98	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.81600263
99	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.80170734
100	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.79981930

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.19694127
2	MP0003950_abnormal_plasma_membrane	4.91032436
3	MP0002139_abnormal_hepatobiliary_system	3.56505189
4	MP0008438_abnormal_cutaneous_collagen	3.32047802
5	MP0003806_abnormal_nucleotide_metabolis	3.28915583
6	MP0003705_abnormal_hypodermis_morpholog	3.28556674
7	MP0003191_abnormal_cellular_cholesterol	3.06121238
8	MP0010368_abnormal_lymphatic_system	2.88594280
9	MP0010234_abnormal_vibrissa_follicle	2.82621693
10	MP0009840_abnormal_foam_cell	2.58316952
11	MP0003566_abnormal_cell_adhesion	2.57841616
12	MP0004272_abnormal_basement_membrane	2.45752039
13	MP0005023_abnormal_wound_healing	2.40335729
14	MP0009780_abnormal_chondrocyte_physiolo	2.14350862
15	MP0008875_abnormal_xenobiotic_pharmacok	1.91523421
16	MP0005365_abnormal_bile_salt	1.89178389
17	MP0005085_abnormal_gallbladder_physiolo	1.87514525
18	MP0003186_abnormal_redox_activity	1.86829659
19	MP0005623_abnormal_meninges_morphology	1.83240668
20	MP0005670_abnormal_white_adipose	1.82978721
21	MP0001879_abnormal_lymphatic_vessel	1.79926654
22	MP0001666_abnormal_nutrient_absorption	1.70553203
23	MP0003011_delayed_dark_adaptation	1.62550342
24	MP0004019_abnormal_vitamin_homeostasis	1.61752270
25	MP0003279_aneurysm	1.59406407
26	MP0010352_gastrointestinal_tract_polyps	1.59160525
27	MP0003453_abnormal_keratinocyte_physiol	1.56742552
28	MP0005451_abnormal_body_composition	1.54000952
29	MP0010329_abnormal_lipoprotein_level	1.53696681
30	MP0000013_abnormal_adipose_tissue	1.53061922
31	MP0005332_abnormal_amino_acid	1.49426224
32	MP0002060_abnormal_skin_morphology	1.48760814
33	MP0004510_myositis	1.48378151
34	MP0003091_abnormal_cell_migration	1.47609731
35	MP0005275_abnormal_skin_tensile	1.45970686
36	MP0005666_abnormal_adipose_tissue	1.45007529
37	MP0003075_altered_response_to	1.44362535
38	MP0000762_abnormal_tongue_morphology	1.41881455
39	MP0003868_abnormal_feces_composition	1.40381021
40	MP0002877_abnormal_melanocyte_morpholog	1.35375915
41	MP0005257_abnormal_intraocular_pressure	1.32253796
42	MP0010030_abnormal_orbit_morphology	1.32059146
43	MP0000343_altered_response_to	1.30944584
44	MP0002295_abnormal_pulmonary_circulatio	1.30049882
45	MP0005164_abnormal_response_to	1.28348956
46	MP0005375_adipose_tissue_phenotype	1.27876442
47	MP0001853_heart_inflammation	1.27368345
48	MP0005166_decreased_susceptibility_to	1.26022831
49	MP0009053_abnormal_anal_canal	1.19885032
50	MP0005165_increased_susceptibility_to	1.17131210
51	MP0002796_impaired_skin_barrier	1.10982081
52	MP0000858_altered_metastatic_potential	1.10929966
53	MP0001216_abnormal_epidermal_layer	1.08811271
54	MP0005584_abnormal_enzyme/coenzyme_acti	1.05807357
55	MP0000003_abnormal_adipose_tissue	1.05207452
56	MP0009697_abnormal_copulation	1.05155499
57	MP0005501_abnormal_skin_physiology	1.04777185
58	MP0003252_abnormal_bile_duct	1.03041036
59	MP0001849_ear_inflammation	1.01658784
60	MP0001661_extended_life_span	1.01442693
61	MP0000750_abnormal_muscle_regeneration	1.00698973
62	MP0001958_emphysema	0.99931913
63	MP0009379_abnormal_foot_pigmentation	0.99490521
64	MP0000678_abnormal_parathyroid_gland	0.97478139
65	MP0005595_abnormal_vascular_smooth	0.96583495
66	MP0009643_abnormal_urine_homeostasis	0.95951696
67	MP0002971_abnormal_brown_adipose	0.93072827
68	MP0002332_abnormal_exercise_endurance	0.92621040
69	MP0005058_abnormal_lysosome_morphology	0.91781450
70	MP0003941_abnormal_skin_development	0.91479219
71	MP0002118_abnormal_lipid_homeostasis	0.90865301
72	MP0008260_abnormal_autophagy	0.90599032
73	MP0004233_abnormal_muscle_weight	0.90185707
74	MP0006054_spinal_hemorrhage	0.90139595
75	MP0001542_abnormal_bone_strength	0.89765600
76	MP0003195_calcinosis	0.89123236
77	MP0000609_abnormal_liver_physiology	0.86432375
78	MP0002896_abnormal_bone_mineralization	0.85946676
79	MP0000749_muscle_degeneration	0.81410723
80	MP0002138_abnormal_hepatobiliary_system	0.81379159
81	MP0003448_altered_tumor_morphology	0.79374529
82	MP0001881_abnormal_mammary_gland	0.76629584
83	MP0004947_skin_inflammation	0.73645551
84	MP0000249_abnormal_blood_vessel	0.73506788
85	MP0002876_abnormal_thyroid_physiology	0.73353423
86	MP0009763_increased_sensitivity_to	0.71250012
87	MP0001243_abnormal_dermal_layer	0.70973295
88	MP0005330_cardiomyopathy	0.69833308
89	MP0002136_abnormal_kidney_physiology	0.67997504
90	MP0009764_decreased_sensitivity_to	0.67239907
91	MP0010771_integument_phenotype	0.67214062
92	MP0003879_abnormal_hair_cell	0.63292023
93	MP0002234_abnormal_pharynx_morphology	0.62549902
94	MP0004883_abnormal_blood_vessel	0.62424415
95	MP0000467_abnormal_esophagus_morphology	0.62424203
96	MP0001299_abnormal_eye_distance/	0.62350744
97	MP0005319_abnormal_enzyme/_coenzyme	0.60907602
98	MP0000733_abnormal_muscle_development	0.59581982
99	MP0005409_darkened_coat_color	0.59255943
100	MP0001756_abnormal_urination	0.58890316

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.09605285
2	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.71226933
3	Abnormality of complement system (HP:0005339)	4.07874592
4	Complement deficiency (HP:0004431)	3.94283191
5	Systemic lupus erythematosus (HP:0002725)	3.68893797
6	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.54115235
7	Premature rupture of membranes (HP:0001788)	3.53336701
8	Abnormality of the intrinsic pathway (HP:0010989)	3.46460519
9	Deep venous thrombosis (HP:0002625)	3.35675295
10	Xanthomatosis (HP:0000991)	3.28972726
11	Atrophic scars (HP:0001075)	3.19300876
12	Cardiovascular calcification (HP:0011915)	3.10142602
13	Vertebral compression fractures (HP:0002953)	3.08918832
14	Vascular calcification (HP:0004934)	3.06404368
15	Prolonged partial thromboplastin time (HP:0003645)	3.02201018
16	Reduced subcutaneous adipose tissue (HP:0003758)	2.98679125
17	Conjugated hyperbilirubinemia (HP:0002908)	2.96131826
18	Hypobetalipoproteinemia (HP:0003563)	2.96085604
19	Axonal loss (HP:0003447)	2.95034615
20	Hypoalphalipoproteinemia (HP:0003233)	2.90606248
21	Cervical subluxation (HP:0003308)	2.83337017
22	Hypolipoproteinemia (HP:0010981)	2.67733150
23	Mitral stenosis (HP:0001718)	2.67036928
24	Protrusio acetabuli (HP:0003179)	2.62633959
25	Insulin resistance (HP:0000855)	2.60959898
26	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.58289572
27	Osteolytic defects of the hand bones (HP:0009699)	2.58289572
28	Acanthosis nigricans (HP:0000956)	2.57856236
29	Fat malabsorption (HP:0002630)	2.57167543
30	Hyperlipoproteinemia (HP:0010980)	2.52768632
31	Onycholysis (HP:0001806)	2.50976911
32	Spinal cord compression (HP:0002176)	2.49540712
33	Abnormality of carpal bone ossification (HP:0006257)	2.49234191
34	Intrahepatic cholestasis (HP:0001406)	2.45872384
35	Steatorrhea (HP:0002570)	2.45602520
36	Glomerulonephritis (HP:0000099)	2.41608401
37	Short nail (HP:0001799)	2.39206191
38	Milia (HP:0001056)	2.34201109
39	Alopecia of scalp (HP:0002293)	2.32962677
40	Glucose intolerance (HP:0000833)	2.32348630
41	Abnormality of proline metabolism (HP:0010907)	2.31324774
42	Hydroxyprolinuria (HP:0003080)	2.31324774
43	Abnormality of the Achilles tendon (HP:0005109)	2.27327899
44	Malnutrition (HP:0004395)	2.27091010
45	Hyperparathyroidism (HP:0000843)	2.26127611
46	Distal lower limb muscle weakness (HP:0009053)	2.25947468
47	Joint hemorrhage (HP:0005261)	2.25372026
48	Ankle contracture (HP:0006466)	2.24821483
49	Increased serum pyruvate (HP:0003542)	2.24397413
50	Myocardial infarction (HP:0001658)	2.22924158
51	Abnormality of the common coagulation pathway (HP:0010990)	2.22439936
52	Nephritis (HP:0000123)	2.21164184
53	Abnormality of pyrimidine metabolism (HP:0004353)	2.20790418
54	Abnormal glucose tolerance (HP:0001952)	2.18262513
55	Generalized amyotrophy (HP:0003700)	2.15953653
56	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.14934060
57	Right ventricular cardiomyopathy (HP:0011663)	2.14850792
58	Abnormality of placental membranes (HP:0011409)	2.12337912
59	Amniotic constriction ring (HP:0009775)	2.12337912
60	Fragile nails (HP:0001808)	2.10496742
61	Abnormality of glycolysis (HP:0004366)	2.09950217
62	Achilles tendon contracture (HP:0001771)	2.07170384
63	Amyloidosis (HP:0011034)	2.05984633
64	Nail dystrophy (HP:0008404)	2.05842219
65	Fragile skin (HP:0001030)	2.04699422
66	Upper limb amyotrophy (HP:0009129)	2.01162633
67	Distal upper limb amyotrophy (HP:0007149)	2.01162633
68	Ileus (HP:0002595)	1.98878493
69	Thick nail (HP:0001805)	1.98281964
70	Focal segmental glomerulosclerosis (HP:0000097)	1.97744392
71	Plantar hyperkeratosis (HP:0007556)	1.96493074
72	Abnormal ossification of hand bones (HP:0005921)	1.96319876
73	Distal lower limb amyotrophy (HP:0008944)	1.96272940
74	Abnormal gallbladder physiology (HP:0012438)	1.94795566
75	Cholecystitis (HP:0001082)	1.94795566
76	Follicular hyperkeratosis (HP:0007502)	1.94422181
77	Hyperammonemia (HP:0001987)	1.94300840
78	Wormian bones (HP:0002645)	1.93202497
79	Natal tooth (HP:0000695)	1.91221152
80	Bone cyst (HP:0012062)	1.88186429
81	Multiple lipomas (HP:0001012)	1.88033782
82	Vascular tortuosity (HP:0004948)	1.86588521
83	Rhabdomyolysis (HP:0003201)	1.86085298
84	Increased serum ferritin (HP:0003281)	1.84049836
85	Elbow flexion contracture (HP:0002987)	1.82198199
86	Reduced antithrombin III activity (HP:0001976)	1.80314231
87	Abnormal hair laboratory examination (HP:0003328)	1.79068574
88	Delayed gross motor development (HP:0002194)	1.78097951
89	Hypertriglyceridemia (HP:0002155)	1.77116264
90	Chondrocalcinosis (HP:0000934)	1.76891644
91	Confusion (HP:0001289)	1.75143808
92	Abnormal hand bone ossification (HP:0010660)	1.74849085
93	Abnormality of Sharpey fibers (HP:0100685)	1.74702499
94	Entropion (HP:0000621)	1.74295524
95	Glomerulosclerosis (HP:0000096)	1.73944241
96	Blue sclerae (HP:0000592)	1.72525353
97	Abnormality of liposaccharide metabolism (HP:0010968)	1.72281178
98	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.72281178
99	Abnormality of glycolipid metabolism (HP:0010969)	1.72281178
100	Generalized aminoaciduria (HP:0002909)	1.71979362

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	4.20808382
2	EPHA2	3.48380075
3	ARAF	3.45242279
4	NME2	3.09786065
5	MAP3K12	3.08386518
6	TESK1	3.06088464
7	IRAK3	3.00127888
8	MET	2.84700015
9	MAP3K3	2.59920855
10	LIMK1	2.56290478
11	LMTK2	2.40139992
12	MYLK	2.28588041
13	PTK2	2.27808244
14	PAK4	2.24604340
15	MST4	2.16936273
16	BUB1	2.02785464
17	ABL2	2.02600809
18	EPHB2	1.96336368
19	DDR2	1.89410307
20	ERN1	1.89098994
21	LATS2	1.86699883
22	PIM2	1.83519351
23	PBK	1.82916925
24	STK24	1.82311795
25	ILK	1.82063771
26	PDGFRA	1.81616166
27	RIPK1	1.73125676
28	MOS	1.65212938
29	NEK1	1.63840932
30	NTRK1	1.49024832
31	ERBB4	1.43652503
32	FLT3	1.38029838
33	TAOK2	1.24992429
34	PRKG2	1.17907203
35	MAP3K9	1.17474949
36	TGFBR2	1.14617244
37	PRPF4B	1.14226998
38	BRAF	1.13912813
39	PAK6	1.12879234
40	EPHB1	1.11685600
41	EIF2AK1	1.04392505
42	MAP3K13	0.99432144
43	TESK2	0.95374118
44	STK10	0.83722937
45	PAK2	0.81126710
46	EIF2AK3	0.76455630
47	TTN	0.75927041
48	PHKG1	0.70267786
49	PHKG2	0.70267786
50	PRKCI	0.68185080
51	CLK1	0.66615297
52	STK38	0.66568029
53	CAMK2G	0.66164036
54	STK16	0.64879556
55	DAPK3	0.63243944
56	PAK1	0.62647663
57	MAP4K2	0.62076137
58	MAP3K8	0.61988450
59	ROCK2	0.60196429
60	PDGFRB	0.60138462
61	VRK2	0.59304599
62	MAPKAPK3	0.58500080
63	PDK2	0.58361877
64	MUSK	0.57926542
65	GSK3A	0.56278015
66	BMX	0.54486503
67	DAPK1	0.53288108
68	RAF1	0.52870006
69	DMPK	0.52207757
70	KSR2	0.49515757
71	ROCK1	0.49374264
72	SIK1	0.48974037
73	ADRBK1	0.47161105
74	AKT2	0.47008003
75	TRIB3	0.44847901
76	CAMK2D	0.44495627
77	CDK8	0.43436671
78	TRPM7	0.43116525
79	MAP3K1	0.41261354
80	PTK2B	0.39610336
81	SCYL2	0.38540212
82	PTK6	0.37436504
83	MAP2K3	0.34526327
84	AURKA	0.33448826
85	MAP3K2	0.33172324
86	PDPK1	0.33018647
87	BRSK1	0.31995240
88	LRRK2	0.31809928
89	CAMK2B	0.30463626
90	CDC42BPA	0.30196896
91	MELK	0.29370018
92	PRKD2	0.28077098
93	FER	0.26214749
94	STK3	0.25623814
95	TBK1	0.25362545
96	MAP3K11	0.22586442
97	MAPK11	0.21251687
98	ZAP70	0.21050609
99	SMG1	0.21044779
100	CDK9	0.20683579

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Mineral absorption_Homo sapiens_hsa04978	3.70063765
2	Sulfur metabolism_Homo sapiens_hsa00920	3.05461372
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.76887309
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.72331738
5	Complement and coagulation cascades_Homo sapiens_hsa04610	2.69403466
6	Phenylalanine metabolism_Homo sapiens_hsa00360	2.58227821
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.51958087
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.51512122
9	Caffeine metabolism_Homo sapiens_hsa00232	2.42906669
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.25474559
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.05853982
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.98841913
13	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.97554016
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.96273512
15	Tyrosine metabolism_Homo sapiens_hsa00350	1.94773848
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.88920856
17	Retinol metabolism_Homo sapiens_hsa00830	1.87744492
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.84137385
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.83687502
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.83440149
21	Glutathione metabolism_Homo sapiens_hsa00480	1.80139045
22	Fatty acid degradation_Homo sapiens_hsa00071	1.78035390
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.75233000
24	Folate biosynthesis_Homo sapiens_hsa00790	1.74609783
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.72786254
26	Galactose metabolism_Homo sapiens_hsa00052	1.68647083
27	Histidine metabolism_Homo sapiens_hsa00340	1.67544660
28	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.63717670
29	Prion diseases_Homo sapiens_hsa05020	1.51519014
30	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.49936915
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.48798869
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.47082443
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46490982
34	Arginine and proline metabolism_Homo sapiens_hsa00330	1.43583840
35	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.39942165
36	Sulfur relay system_Homo sapiens_hsa04122	1.39127117
37	Proteasome_Homo sapiens_hsa03050	1.38170210
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.34497288
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.22540598
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.20776993
41	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.20034552
42	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.17857571
43	Pentose phosphate pathway_Homo sapiens_hsa00030	1.13673484
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.08057275
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.05368389
46	Carbon metabolism_Homo sapiens_hsa01200	1.03392013
47	Renin-angiotensin system_Homo sapiens_hsa04614	1.03155967
48	Bile secretion_Homo sapiens_hsa04976	1.02352983
49	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00351388
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98094318
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96275620
52	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.94626389
53	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.94180274
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91309430
55	Other glycan degradation_Homo sapiens_hsa00511	0.91233529
56	ECM-receptor interaction_Homo sapiens_hsa04512	0.83092565
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81338677
58	Vibrio cholerae infection_Homo sapiens_hsa05110	0.80593566
59	Pertussis_Homo sapiens_hsa05133	0.79656250
60	Shigellosis_Homo sapiens_hsa05131	0.70743442
61	Protein digestion and absorption_Homo sapiens_hsa04974	0.70576229
62	Fatty acid elongation_Homo sapiens_hsa00062	0.68670631
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.66991892
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65211897
65	Focal adhesion_Homo sapiens_hsa04510	0.64891767
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63897621
67	Proteoglycans in cancer_Homo sapiens_hsa05205	0.60860124
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.58424408
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57060819
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54271147
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.53060230
72	Peroxisome_Homo sapiens_hsa04146	0.51635292
73	Metabolic pathways_Homo sapiens_hsa01100	0.51248030
74	Salmonella infection_Homo sapiens_hsa05132	0.50627125
75	Amoebiasis_Homo sapiens_hsa05146	0.49448860
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.44565662
77	One carbon pool by folate_Homo sapiens_hsa00670	0.43112708
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41339566
79	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.40073292
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38994569
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37998332
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.35805580
83	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.34880892
84	Bladder cancer_Homo sapiens_hsa05219	0.31039166
85	Linoleic acid metabolism_Homo sapiens_hsa00591	0.30501202
86	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.29314555
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.28994761
88	p53 signaling pathway_Homo sapiens_hsa04115	0.28733322
89	African trypanosomiasis_Homo sapiens_hsa05143	0.25560774
90	Alzheimers disease_Homo sapiens_hsa05010	0.25247079
91	Insulin resistance_Homo sapiens_hsa04931	0.24848439
92	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23947729
93	Tight junction_Homo sapiens_hsa04530	0.23883876
94	Circadian rhythm_Homo sapiens_hsa04710	0.22712929
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.22188504
96	Adherens junction_Homo sapiens_hsa04520	0.21704925
97	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.20226145
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.20172913
99	TNF signaling pathway_Homo sapiens_hsa04668	0.19291300
100	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.18795677

MT1E

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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