ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* cellular response to cadmium ion (GO:0071276)	9.01716125
2	epoxygenase P450 pathway (GO:0019373)	5.78555875
3	fat-soluble vitamin biosynthetic process (GO:0042362)	5.40997267
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.87114848
5	L-phenylalanine metabolic process (GO:0006558)	4.87114848
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.81044603
7	L-phenylalanine catabolic process (GO:0006559)	4.81044603
8	* response to zinc ion (GO:0010043)	4.76186060
9	omega-hydroxylase P450 pathway (GO:0097267)	4.56598789
10	angiotensin maturation (GO:0002003)	4.38483222
11	eosinophil chemotaxis (GO:0048245)	4.26671852
12	positive regulation of lipoprotein lipase activity (GO:0051006)	4.11225546
13	positive regulation of triglyceride lipase activity (GO:0061365)	4.11225546
14	regulation of mononuclear cell migration (GO:0071675)	4.03683849
15	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.93199371
16	vitamin biosynthetic process (GO:0009110)	3.91491154
17	aromatic amino acid family catabolic process (GO:0009074)	3.88880913
18	exogenous drug catabolic process (GO:0042738)	3.87503863
19	drug catabolic process (GO:0042737)	3.84870142
20	eosinophil migration (GO:0072677)	3.75302471
21	regulation of cholesterol esterification (GO:0010872)	3.73712365
22	drug metabolic process (GO:0017144)	3.65613320
23	phospholipid efflux (GO:0033700)	3.64086120
24	ethanol oxidation (GO:0006069)	3.60208902
25	* response to cadmium ion (GO:0046686)	3.59375127
26	regulation of macrophage chemotaxis (GO:0010758)	3.51023454
27	complement activation, alternative pathway (GO:0006957)	3.49593752
28	fructose metabolic process (GO:0006000)	3.47290946
29	regulation of triglyceride catabolic process (GO:0010896)	3.40086797
30	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.37534194
31	acute-phase response (GO:0006953)	3.33820086
32	plasma lipoprotein particle remodeling (GO:0034369)	3.24268449
33	protein-lipid complex remodeling (GO:0034368)	3.24268449
34	macromolecular complex remodeling (GO:0034367)	3.24268449
35	negative regulation of cholesterol transport (GO:0032375)	3.21589077
36	negative regulation of sterol transport (GO:0032372)	3.21589077
37	L-ascorbic acid metabolic process (GO:0019852)	3.20738872
38	oligosaccharide catabolic process (GO:0009313)	3.19270300
39	high-density lipoprotein particle remodeling (GO:0034375)	3.18001032
40	cholesterol efflux (GO:0033344)	3.12863757
41	reverse cholesterol transport (GO:0043691)	3.11675114
42	triglyceride homeostasis (GO:0070328)	3.09974388
43	acylglycerol homeostasis (GO:0055090)	3.09974388
44	indole-containing compound catabolic process (GO:0042436)	3.06957633
45	indolalkylamine catabolic process (GO:0046218)	3.06957633
46	tryptophan catabolic process (GO:0006569)	3.06957633
47	xenobiotic catabolic process (GO:0042178)	3.04440576
48	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.95263720
49	glycosphingolipid catabolic process (GO:0046479)	2.94776687
50	urea metabolic process (GO:0019627)	2.93210925
51	glucuronate metabolic process (GO:0019585)	2.89264391
52	uronic acid metabolic process (GO:0006063)	2.89264391
53	phenylpropanoid metabolic process (GO:0009698)	2.88523071
54	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.88434471
55	nitrogen cycle metabolic process (GO:0071941)	2.86990892
56	vitamin D metabolic process (GO:0042359)	2.85495725
57	peptide hormone processing (GO:0016486)	2.83287322
58	glycolipid catabolic process (GO:0019377)	2.82216340
59	peptide catabolic process (GO:0043171)	2.80310427
60	glyoxylate metabolic process (GO:0046487)	2.76921107
61	amine catabolic process (GO:0009310)	2.74602168
62	cellular biogenic amine catabolic process (GO:0042402)	2.74602168
63	bile acid metabolic process (GO:0008206)	2.73822346
64	urea cycle (GO:0000050)	2.72449692
65	regulation of guanylate cyclase activity (GO:0031282)	2.72107302
66	ethanol metabolic process (GO:0006067)	2.70583011
67	cellular glucuronidation (GO:0052695)	2.69904531
68	bile acid and bile salt transport (GO:0015721)	2.67225983
69	membrane lipid catabolic process (GO:0046466)	2.63820070
70	hydrogen peroxide biosynthetic process (GO:0050665)	2.61087160
71	bile acid biosynthetic process (GO:0006699)	2.60561100
72	adhesion of symbiont to host cell (GO:0044650)	2.59987540
73	virion attachment to host cell (GO:0019062)	2.59987540
74	low-density lipoprotein particle remodeling (GO:0034374)	2.59701309
75	NADH metabolic process (GO:0006734)	2.58832109
76	positive regulation of cellular amine metabolic process (GO:0033240)	2.58680571
77	sphingolipid catabolic process (GO:0030149)	2.58486817
78	L-alpha-amino acid transmembrane transport (GO:1902475)	2.56287190
79	heme transport (GO:0015886)	2.55079793
80	regulation of fibrinolysis (GO:0051917)	2.53999967
81	fat-soluble vitamin metabolic process (GO:0006775)	2.51604252
82	regulation of cholesterol homeostasis (GO:2000188)	2.51307186
83	plasma lipoprotein particle organization (GO:0071827)	2.50633969
84	acute inflammatory response (GO:0002526)	2.49687123
85	positive regulation of triglyceride metabolic process (GO:0090208)	2.48089977
86	very-low-density lipoprotein particle assembly (GO:0034379)	2.44909056
87	lipoprotein metabolic process (GO:0042157)	2.43600848
88	aromatic amino acid family metabolic process (GO:0009072)	2.43262024
89	regulation of bile acid biosynthetic process (GO:0070857)	2.43107654
90	complement activation (GO:0006956)	2.42449456
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.41985041
92	intestinal absorption (GO:0050892)	2.41873621
93	ceramide catabolic process (GO:0046514)	2.41836332
94	regulation of oxidative phosphorylation (GO:0002082)	2.41680016
95	protein-lipid complex subunit organization (GO:0071825)	2.41174438
96	regulation of protein activation cascade (GO:2000257)	2.39889271
97	cellular ketone body metabolic process (GO:0046950)	2.39368320
98	complement activation, classical pathway (GO:0006958)	2.37820823
99	positive regulation of icosanoid secretion (GO:0032305)	2.37805868
100	* cellular response to zinc ion (GO:0071294)	12.2330107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.49292307
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.43556044
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.19323744
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.02118939
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.96417308
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.89826365
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.78728712
8	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.72367464
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.71681913
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.69601667
11	* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.64236537
12	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.63191498
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.38819746
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.33111279
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.28382670
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.27718963
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.23870493
18	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.13380091
19	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.01344835
20	HTT_18923047_ChIP-ChIP_STHdh_Human	1.76464142
21	* SOX2_20726797_ChIP-Seq_SW620_Human	1.73952649
22	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.72335514
23	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.69819453
24	BCOR_27268052_Chip-Seq_Bcells_Human	1.55567572
25	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.55382005
26	LXR_22292898_ChIP-Seq_THP-1_Human	1.53630391
27	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.51376794
28	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.50423262
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50234206
30	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.42576987
31	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.41952937
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37286239
33	GATA4_25053715_ChIP-Seq_YYC3_Human	1.36722333
34	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35084984
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.35081724
36	STAT1_20625510_ChIP-Seq_HELA_Human	1.30136824
37	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.27263887
38	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.26355485
39	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.25106061
40	BCL6_27268052_Chip-Seq_Bcells_Human	1.21161195
41	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.20121469
42	SA1_27219007_Chip-Seq_Bcells_Human	1.19914488
43	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.19778906
44	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.19710405
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.16975000
46	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.16677293
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16296403
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15037503
49	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.13848652
50	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.12824643
51	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.12694649
52	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.11630261
53	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.10170749
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08253406
55	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.08231709
56	AR_20517297_ChIP-Seq_VCAP_Human	1.07950604
57	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.07688995
58	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.06952567
59	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.04821485
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04728871
61	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.04115694
62	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.02148971
63	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.01940786
64	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.01040520
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00371401
66	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.98833928
67	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.97960895
68	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.97724185
69	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.97447215
70	CBP_21632823_ChIP-Seq_H3396_Human	0.96210525
71	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95692409
72	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.95453106
73	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94221533
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92676973
75	PHF8_20622854_ChIP-Seq_HELA_Human	0.92328975
76	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.92133859
77	P300_27268052_Chip-Seq_Bcells_Human	0.91597946
78	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.90797929
79	* HNF4A_19822575_ChIP-Seq_HepG2_Human	0.90776520
80	SOX2_21211035_ChIP-Seq_LN229_Human	0.90180169
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.89636346
82	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.89517452
83	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89269450
84	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.87942062
85	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.86928117
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86589440
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86589440
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.85667392
89	OCT4_20526341_ChIP-Seq_ESCs_Human	0.85484752
90	E2F1_20622854_ChIP-Seq_HELA_Human	0.85247210
91	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.84623746
92	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.84603081
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.83875721
94	ERA_21632823_ChIP-Seq_H3396_Human	0.83342617
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.83160385
96	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.80975962
97	CTCF_27219007_Chip-Seq_Bcells_Human	0.79881591
98	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.79342881
99	GATA6_25053715_ChIP-Seq_YYC3_Human	0.79290459
100	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.79240313

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.81149998
2	MP0009840_abnormal_foam_cell	4.20842538
3	MP0003195_calcinosis	4.13671573
4	MP0005360_urolithiasis	3.82808409
5	MP0005365_abnormal_bile_salt	3.66575996
6	MP0005085_abnormal_gallbladder_physiolo	3.10267148
7	MP0004019_abnormal_vitamin_homeostasis	2.93539435
8	MP0003806_abnormal_nucleotide_metabolis	2.88260315
9	MP0009785_altered_susceptibility_to	2.84177556
10	MP0002837_dystrophic_cardiac_calcinosis	2.70209130
11	MP0001666_abnormal_nutrient_absorption	2.52706773
12	MP0008875_abnormal_xenobiotic_pharmacok	2.51668090
13	MP0005058_abnormal_lysosome_morphology	2.25950191
14	MP0010329_abnormal_lipoprotein_level	2.17905855
15	MP0005332_abnormal_amino_acid	2.16132467
16	MP0002138_abnormal_hepatobiliary_system	2.07101950
17	MP0003075_altered_response_to	2.05826395
18	MP0002148_abnormal_hypersensitivity_rea	1.97578555
19	MP0003879_abnormal_hair_cell	1.90173212
20	MP0006082_CNS_inflammation	1.83756322
21	MP0003191_abnormal_cellular_cholesterol	1.80659562
22	MP0003183_abnormal_peptide_metabolism	1.79279116
23	MP0005166_decreased_susceptibility_to	1.76334613
24	MP0003172_abnormal_lysosome_physiology	1.71222588
25	MP0009764_decreased_sensitivity_to	1.67835330
26	MP0004510_myositis	1.65841683
27	MP0003436_decreased_susceptibility_to	1.64277599
28	MP0005167_abnormal_blood-brain_barrier	1.63670403
29	MP0003011_delayed_dark_adaptation	1.63248858
30	MP0001764_abnormal_homeostasis	1.54579345
31	MP0000343_altered_response_to	1.51208024
32	MP0002909_abnormal_adrenal_gland	1.48964072
33	MP0009643_abnormal_urine_homeostasis	1.47850402
34	MP0002876_abnormal_thyroid_physiology	1.46646808
35	MP0005025_abnormal_response_to	1.46538870
36	MP0001845_abnormal_inflammatory_respons	1.42889680
37	MP0002254_reproductive_system_inflammat	1.39764006
38	MP0005636_abnormal_mineral_homeostasis	1.39640962
39	MP0008469_abnormal_protein_level	1.39235254
40	MP0005671_abnormal_response_to	1.36638825
41	MP0010155_abnormal_intestine_physiology	1.34604701
42	MP0002419_abnormal_innate_immunity	1.34493827
43	MP0003690_abnormal_glial_cell	1.31299150
44	MP0010386_abnormal_urinary_bladder	1.31007607
45	MP0002118_abnormal_lipid_homeostasis	1.30939601
46	MP0002277_abnormal_respiratory_mucosa	1.30117353
47	MP0000604_amyloidosis	1.27281020
48	MP0001756_abnormal_urination	1.26979291
49	MP0002693_abnormal_pancreas_physiology	1.24588296
50	MP0001853_heart_inflammation	1.21407099
51	MP0003252_abnormal_bile_duct	1.17197936
52	MP0010234_abnormal_vibrissa_follicle	1.14688946
53	MP0003186_abnormal_redox_activity	1.13885797
54	MP0001790_abnormal_immune_system	1.13217546
55	MP0005387_immune_system_phenotype	1.13217546
56	MP0005000_abnormal_immune_tolerance	1.12913364
57	MP0000609_abnormal_liver_physiology	1.08456563
58	MP0005379_endocrine/exocrine_gland_phen	1.07354079
59	MP0005319_abnormal_enzyme/_coenzyme	1.07239574
60	MP0001533_abnormal_skeleton_physiology	1.05994827
61	MP0005584_abnormal_enzyme/coenzyme_acti	1.04905459
62	MP0003868_abnormal_feces_composition	1.02545883
63	MP0005535_abnormal_body_temperature	1.00220496
64	MP0001765_abnormal_ion_homeostasis	1.00109593
65	MP0006036_abnormal_mitochondrial_physio	0.98910848
66	MP0004043_abnormal_pH_regulation	0.97823384
67	MP0000920_abnormal_myelination	0.97384818
68	MP0005448_abnormal_energy_balance	0.96173160
69	MP0002078_abnormal_glucose_homeostasis	0.94456385
70	MP0002998_abnormal_bone_remodeling	0.93008026
71	MP0005310_abnormal_salivary_gland	0.88983386
72	MP0003300_gastrointestinal_ulcer	0.88956381
73	MP0003638_abnormal_response/metabolism_	0.88027030
74	MP0001485_abnormal_pinna_reflex	0.84775255
75	MP0009642_abnormal_blood_homeostasis	0.82329487
76	MP0003866_abnormal_defecation	0.82321739
77	MP0003633_abnormal_nervous_system	0.82172513
78	MP0005670_abnormal_white_adipose	0.81937347
79	MP0009333_abnormal_splenocyte_physiolog	0.81856977
80	MP0001501_abnormal_sleep_pattern	0.81353392
81	MP0002136_abnormal_kidney_physiology	0.80425480
82	MP0009780_abnormal_chondrocyte_physiolo	0.79479535
83	MP0000685_abnormal_immune_system	0.78997855
84	MP0009763_increased_sensitivity_to	0.78013600
85	MP0004264_abnormal_extraembryonic_tissu	0.75151079
86	MP0009765_abnormal_xenobiotic_induced	0.73301725
87	MP0002090_abnormal_vision	0.73261443
88	MP0002723_abnormal_immune_serum	0.72804238
89	MP0009379_abnormal_foot_pigmentation	0.71763591
90	MP0002452_abnormal_antigen_presenting	0.71566875
91	MP0003953_abnormal_hormone_level	0.71231680
92	MP0001835_abnormal_antigen_presentation	0.70596130
93	MP0001944_abnormal_pancreas_morphology	0.70575138
94	MP0008004_abnormal_stomach_pH	0.70354287
95	MP0008874_decreased_physiological_sensi	0.69042153
96	MP0002064_seizures	0.65972321
97	MP0008872_abnormal_physiological_respon	0.65558411
98	MP0003303_peritoneal_inflammation	0.64447931
99	MP0002163_abnormal_gland_morphology	0.62776290
100	MP0003283_abnormal_digestive_organ	0.62530562

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.53677610
2	Systemic lupus erythematosus (HP:0002725)	5.28523772
3	Complement deficiency (HP:0004431)	4.38191974
4	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.31980446
5	Xanthomatosis (HP:0000991)	3.88248994
6	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.86439231
7	Malnutrition (HP:0004395)	3.81396178
8	Glomerulonephritis (HP:0000099)	3.54200091
9	Recurrent gram-negative bacterial infections (HP:0005420)	3.51824798
10	Abnormality of glycolipid metabolism (HP:0010969)	3.46216664
11	Abnormality of liposaccharide metabolism (HP:0010968)	3.46216664
12	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.46216664
13	Symptomatic seizures (HP:0011145)	3.43751600
14	Abnormality of complement system (HP:0005339)	3.32586967
15	Hypobetalipoproteinemia (HP:0003563)	3.31460002
16	Hydroxyprolinuria (HP:0003080)	3.28286615
17	Abnormality of proline metabolism (HP:0010907)	3.28286615
18	Hypoglycemic seizures (HP:0002173)	3.14259453
19	Generalized aminoaciduria (HP:0002909)	3.08822435
20	Prolonged partial thromboplastin time (HP:0003645)	3.06406786
21	Hypoglycemic coma (HP:0001325)	3.00788156
22	Vacuolated lymphocytes (HP:0001922)	2.97112809
23	Abnormality of macrophages (HP:0004311)	2.94612721
24	Abnormality of magnesium homeostasis (HP:0004921)	2.89262340
25	Hyperinsulinemic hypoglycemia (HP:0000825)	2.88382750
26	Glycosuria (HP:0003076)	2.81071715
27	Abnormality of urine glucose concentration (HP:0011016)	2.81071715
28	Recurrent abscess formation (HP:0002722)	2.64697387
29	Late onset (HP:0003584)	2.62678259
30	Ketoacidosis (HP:0001993)	2.62542185
31	Hypomagnesemia (HP:0002917)	2.59428533
32	Fat malabsorption (HP:0002630)	2.56952671
33	Steatorrhea (HP:0002570)	2.53564248
34	Ketosis (HP:0001946)	2.53358278
35	Abnormality of vitamin B metabolism (HP:0004340)	2.53119199
36	Retinal atrophy (HP:0001105)	2.46398642
37	Hyperphosphaturia (HP:0003109)	2.45921578
38	Eczematoid dermatitis (HP:0000976)	2.44711512
39	Hypophosphatemia (HP:0002148)	2.41505943
40	Recurrent bacterial skin infections (HP:0005406)	2.38616126
41	Abnormality of vitamin metabolism (HP:0100508)	2.37907352
42	Hyperlipoproteinemia (HP:0010980)	2.33681159
43	Hyperglycemia (HP:0003074)	2.33395851
44	Nausea (HP:0002018)	2.32428973
45	Mitochondrial inheritance (HP:0001427)	2.32076133
46	Metaphyseal irregularity (HP:0003025)	2.31131285
47	Increased cerebral lipofuscin (HP:0011813)	2.29682868
48	Acute necrotizing encephalopathy (HP:0006965)	2.28668902
49	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.26448161
50	Abnormality of glycine metabolism (HP:0010895)	2.26371600
51	Abnormality of serine family amino acid metabolism (HP:0010894)	2.26371600
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.25369734
53	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.25021498
54	Metabolic alkalosis (HP:0200114)	2.24693003
55	Irritability (HP:0000737)	2.24595636
56	Dysostosis multiplex (HP:0000943)	2.21205751
57	Acute encephalopathy (HP:0006846)	2.20988745
58	Increased serum ferritin (HP:0003281)	2.20612136
59	Mutism (HP:0002300)	2.20435112
60	Hepatic necrosis (HP:0002605)	2.19761811
61	Vascular calcification (HP:0004934)	2.17945555
62	Deep venous thrombosis (HP:0002625)	2.17863552
63	Increased circulating renin level (HP:0000848)	2.17373330
64	Progressive macrocephaly (HP:0004481)	2.16779424
65	Hyperglycinuria (HP:0003108)	2.14642052
66	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.13391335
67	Nephritis (HP:0000123)	2.12818780
68	Abnormality of pyrimidine metabolism (HP:0004353)	2.12646881
69	Renal Fanconi syndrome (HP:0001994)	2.12515767
70	Prolonged neonatal jaundice (HP:0006579)	2.11817379
71	Purpura (HP:0000979)	2.11582821
72	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.10186532
73	Abnormality of polysaccharide metabolism (HP:0011012)	2.10186532
74	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.10186532
75	Progressive neurologic deterioration (HP:0002344)	2.08786858
76	Lethargy (HP:0001254)	2.07632693
77	Tetany (HP:0001281)	2.07465800
78	Petechiae (HP:0000967)	2.06918226
79	Alkalosis (HP:0001948)	2.05780535
80	Megaloblastic anemia (HP:0001889)	2.05152659
81	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04135394
82	Abnormal urine phosphate concentration (HP:0012599)	2.02839946
83	Insulin-resistant diabetes mellitus (HP:0000831)	2.01847053
84	Hyperglycinemia (HP:0002154)	2.00779064
85	Widely patent fontanelles and sutures (HP:0004492)	2.00092907
86	Hypothermia (HP:0002045)	1.98869925
87	Axonal loss (HP:0003447)	1.97665550
88	Abnormality of iron homeostasis (HP:0011031)	1.97094161
89	Intrahepatic cholestasis (HP:0001406)	1.96994617
90	Joint hemorrhage (HP:0005261)	1.95255793
91	Loss of speech (HP:0002371)	1.95017623
92	Mucopolysacchariduria (HP:0008155)	1.94875103
93	Urinary glycosaminoglycan excretion (HP:0003541)	1.94875103
94	Hepatocellular necrosis (HP:0001404)	1.94393581
95	Cerebral edema (HP:0002181)	1.92602428
96	Hyperammonemia (HP:0001987)	1.92551842
97	Abnormality of nucleobase metabolism (HP:0010932)	1.91050006
98	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.90855058
99	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.90699737
100	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.90699737

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	3.75857915
2	MAP3K12	3.55138438
3	TESK1	3.06474726
4	MST4	2.91597925
5	NME2	2.57719189
6	RIPK4	2.34616729
7	FRK	2.18276070
8	TESK2	2.12211058
9	ERN1	2.09770904
10	LIMK1	2.05216146
11	PRKG2	2.02341204
12	LMTK2	1.96958315
13	PINK1	1.96119938
14	STK16	1.94196379
15	MAP3K11	1.88103221
16	DAPK2	1.83797543
17	KDR	1.80465033
18	TYK2	1.77088596
19	OXSR1	1.76623622
20	ABL2	1.75828735
21	BLK	1.71739518
22	MAP2K6	1.67525162
23	ADRBK2	1.67467751
24	NTRK3	1.59635199
25	MAP3K2	1.56829311
26	WNK3	1.49835414
27	DDR2	1.47713703
28	TGFBR2	1.42356211
29	MAP3K3	1.36953454
30	GRK7	1.36489257
31	MATK	1.31975152
32	DAPK1	1.28315236
33	CSK	1.28302280
34	IKBKE	1.27987019
35	IRAK3	1.26033813
36	MAP3K1	1.23529708
37	TAOK1	1.19861189
38	TNIK	1.19045701
39	NLK	1.11099810
40	VRK2	1.08872074
41	INSRR	1.05704437
42	MAP4K1	1.04321435
43	STK39	1.01741798
44	TBK1	1.01307042
45	PASK	1.00058561
46	IKBKB	0.98601573
47	FGR	0.97738285
48	GRK1	0.96177315
49	BCKDK	0.95572215
50	TXK	0.86569798
51	TAOK3	0.85113226
52	ARAF	0.81382266
53	CAMKK2	0.80127598
54	PHKG2	0.79923803
55	PHKG1	0.79923803
56	PRKCG	0.78424309
57	MYLK	0.77974517
58	TNK2	0.77600253
59	STK24	0.77300130
60	CAMK2D	0.75878945
61	EPHA2	0.75245224
62	FGFR2	0.68933417
63	CSF1R	0.68193534
64	CAMK2G	0.64754562
65	LYN	0.64350651
66	MAP4K2	0.64215971
67	PRKAA2	0.63309724
68	PRKCA	0.62977717
69	PRKCI	0.61808809
70	ZAP70	0.59087990
71	IRAK4	0.58015056
72	TAOK2	0.56235213
73	PAK4	0.55211006
74	PAK3	0.54866682
75	PRKCQ	0.53249197
76	PRKACG	0.52287809
77	MAPKAPK3	0.52201740
78	PDPK1	0.48919417
79	CSNK1A1	0.47839303
80	CDC42BPA	0.45601070
81	NME1	0.44737920
82	DAPK3	0.44026490
83	FER	0.41185295
84	PRKCZ	0.41101665
85	JAK1	0.40683067
86	PRKCD	0.40539379
87	BMPR2	0.39628634
88	HIPK2	0.39192718
89	PRKACA	0.38981960
90	CSNK1G1	0.37960936
91	PDK1	0.37954251
92	RIPK1	0.36538096
93	BMX	0.36147909
94	EIF2AK3	0.33974668
95	MAP3K9	0.33935231
96	CSNK1G3	0.33050313
97	PDK2	0.32773364
98	WNK4	0.31071743
99	PRKG1	0.31060369
100	CAMK2A	0.28890093

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Mineral absorption_Homo sapiens_hsa04978	3.89807470
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.86573631
3	Caffeine metabolism_Homo sapiens_hsa00232	2.69837167
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.35094068
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.31770630
6	Histidine metabolism_Homo sapiens_hsa00340	2.17784124
7	Retinol metabolism_Homo sapiens_hsa00830	2.16845892
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.16787356
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.15324102
10	Complement and coagulation cascades_Homo sapiens_hsa04610	2.14477995
11	Sulfur metabolism_Homo sapiens_hsa00920	2.03278178
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.01726647
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.98641222
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.97532537
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95797490
16	Fatty acid degradation_Homo sapiens_hsa00071	1.85583077
17	Fat digestion and absorption_Homo sapiens_hsa04975	1.84587116
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.83897692
19	Folate biosynthesis_Homo sapiens_hsa00790	1.75698392
20	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.72024596
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.70863979
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.69142021
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.66342531
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.58883097
25	PPAR signaling pathway_Homo sapiens_hsa03320	1.53695439
26	Other glycan degradation_Homo sapiens_hsa00511	1.53344993
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.48826247
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45118397
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38481467
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38422340
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.37485101
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.37447823
33	Butanoate metabolism_Homo sapiens_hsa00650	1.32671396
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.32316747
35	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.32109091
36	Renin-angiotensin system_Homo sapiens_hsa04614	1.31608954
37	Lysosome_Homo sapiens_hsa04142	1.29996319
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.29945104
39	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.26399681
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.26365091
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24504735
42	Bile secretion_Homo sapiens_hsa04976	1.22762919
43	Tyrosine metabolism_Homo sapiens_hsa00350	1.21179630
44	Proteasome_Homo sapiens_hsa03050	1.20392572
45	Galactose metabolism_Homo sapiens_hsa00052	1.13298879
46	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.12516888
47	Pertussis_Homo sapiens_hsa05133	1.12292906
48	Glutathione metabolism_Homo sapiens_hsa00480	1.07387160
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06765493
50	Peroxisome_Homo sapiens_hsa04146	1.05087493
51	Parkinsons disease_Homo sapiens_hsa05012	1.03703376
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00295668
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.98432311
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92565416
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.89119851
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.88694239
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88391406
58	Prion diseases_Homo sapiens_hsa05020	0.87307284
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.87071580
60	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.84706212
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84701988
62	Alzheimers disease_Homo sapiens_hsa05010	0.78516317
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76957649
64	Insulin secretion_Homo sapiens_hsa04911	0.75803034
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.73541848
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70328105
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65611999
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65147056
69	Protein digestion and absorption_Homo sapiens_hsa04974	0.62742595
70	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.61706215
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60837845
72	Legionellosis_Homo sapiens_hsa05134	0.59899563
73	Salmonella infection_Homo sapiens_hsa05132	0.59666037
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58160181
75	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.58000194
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.57496409
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.56909019
78	Protein export_Homo sapiens_hsa03060	0.55173040
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.55158468
80	Metabolic pathways_Homo sapiens_hsa01100	0.54452096
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54067932
82	Fatty acid elongation_Homo sapiens_hsa00062	0.52601248
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45997688
84	Huntingtons disease_Homo sapiens_hsa05016	0.45959559
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44004916
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.43797535
87	Phagosome_Homo sapiens_hsa04145	0.43502036
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.42512051
89	Pancreatic secretion_Homo sapiens_hsa04972	0.40286685
90	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.39874010
91	Sulfur relay system_Homo sapiens_hsa04122	0.39820560
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37752023
93	Tuberculosis_Homo sapiens_hsa05152	0.36731282
94	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.35955631
95	African trypanosomiasis_Homo sapiens_hsa05143	0.34353322
96	Carbon metabolism_Homo sapiens_hsa01200	0.32589035
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.30812714
98	TNF signaling pathway_Homo sapiens_hsa04668	0.28769385
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28140412
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.26972215

MT1F

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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