ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* cellular response to cadmium ion (GO:0071276)	9.79240352
2	epoxygenase P450 pathway (GO:0019373)	6.81184351
3	fat-soluble vitamin biosynthetic process (GO:0042362)	5.92834265
4	angiotensin maturation (GO:0002003)	5.27547505
5	omega-hydroxylase P450 pathway (GO:0097267)	5.23488420
6	positive regulation of triglyceride lipase activity (GO:0061365)	4.98233944
7	positive regulation of lipoprotein lipase activity (GO:0051006)	4.98233944
8	exogenous drug catabolic process (GO:0042738)	4.94844244
9	drug catabolic process (GO:0042737)	4.83110487
10	* response to zinc ion (GO:0010043)	4.81077983
11	complement activation, alternative pathway (GO:0006957)	4.68615828
12	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.59100281
13	regulation of triglyceride catabolic process (GO:0010896)	4.33879022
14	ethanol oxidation (GO:0006069)	4.32650578
15	phospholipid efflux (GO:0033700)	4.32534255
16	drug metabolic process (GO:0017144)	4.32454216
17	negative regulation of cholesterol transport (GO:0032375)	4.21788130
18	negative regulation of sterol transport (GO:0032372)	4.21788130
19	urea metabolic process (GO:0019627)	4.19969811
20	eosinophil chemotaxis (GO:0048245)	4.14632308
21	regulation of macrophage chemotaxis (GO:0010758)	4.13322365
22	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.06862857
23	L-phenylalanine metabolic process (GO:0006558)	4.06862857
24	regulation of mononuclear cell migration (GO:0071675)	4.04582249
25	regulation of cholesterol esterification (GO:0010872)	4.03159025
26	* response to cadmium ion (GO:0046686)	4.01643352
27	nitrogen cycle metabolic process (GO:0071941)	4.00177373
28	peptide catabolic process (GO:0043171)	3.99478873
29	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.95415676
30	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.94862593
31	fructose metabolic process (GO:0006000)	3.93695273
32	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.93216332
33	L-phenylalanine catabolic process (GO:0006559)	3.93216332
34	urea cycle (GO:0000050)	3.89805992
35	acute-phase response (GO:0006953)	3.83063641
36	plasma lipoprotein particle remodeling (GO:0034369)	3.66933040
37	protein-lipid complex remodeling (GO:0034368)	3.66933040
38	macromolecular complex remodeling (GO:0034367)	3.66933040
39	glycosphingolipid catabolic process (GO:0046479)	3.65893202
40	eosinophil migration (GO:0072677)	3.65196712
41	glucuronate metabolic process (GO:0019585)	3.61812110
42	uronic acid metabolic process (GO:0006063)	3.61812110
43	cellular glucuronidation (GO:0052695)	3.57287114
44	cholesterol efflux (GO:0033344)	3.55553160
45	glycolipid catabolic process (GO:0019377)	3.55472455
46	bile acid and bile salt transport (GO:0015721)	3.53400776
47	NADH metabolic process (GO:0006734)	3.52372805
48	intestinal absorption (GO:0050892)	3.51936090
49	vitamin biosynthetic process (GO:0009110)	3.40063914
50	very-low-density lipoprotein particle assembly (GO:0034379)	3.36423006
51	glyoxylate metabolic process (GO:0046487)	3.34770172
52	aromatic amino acid family catabolic process (GO:0009074)	3.34674478
53	ethanol metabolic process (GO:0006067)	3.32724823
54	adhesion of symbiont to host cell (GO:0044650)	3.26368756
55	virion attachment to host cell (GO:0019062)	3.26368756
56	bile acid metabolic process (GO:0008206)	3.26221381
57	negative regulation of myeloid cell apoptotic process (GO:0033033)	3.25757814
58	complement activation (GO:0006956)	3.22002510
59	regulation of vitamin metabolic process (GO:0030656)	3.21172240
60	high-density lipoprotein particle remodeling (GO:0034375)	3.20745110
61	regulation of protein activation cascade (GO:2000257)	3.19000993
62	complement activation, classical pathway (GO:0006958)	3.15158442
63	plasma lipoprotein particle assembly (GO:0034377)	3.10829412
64	regulation of fibrinolysis (GO:0051917)	3.08124588
65	neutrophil activation involved in immune response (GO:0002283)	3.06672184
66	regulation of complement activation (GO:0030449)	3.06324915
67	positive regulation of triglyceride metabolic process (GO:0090208)	3.05408210
68	low-density lipoprotein particle remodeling (GO:0034374)	3.03003897
69	reverse cholesterol transport (GO:0043691)	3.01255638
70	plasma lipoprotein particle organization (GO:0071827)	3.00915216
71	regulation of cholesterol homeostasis (GO:2000188)	2.98185228
72	protein activation cascade (GO:0072376)	2.98033981
73	lipoprotein metabolic process (GO:0042157)	2.95208072
74	positive regulation of lipid catabolic process (GO:0050996)	2.94192455
75	ceramide catabolic process (GO:0046514)	2.92857258
76	L-ascorbic acid metabolic process (GO:0019852)	2.92656825
77	membrane lipid catabolic process (GO:0046466)	2.91406229
78	fibrinolysis (GO:0042730)	2.90556549
79	triglyceride homeostasis (GO:0070328)	2.88019212
80	acylglycerol homeostasis (GO:0055090)	2.88019212
81	protein-lipid complex subunit organization (GO:0071825)	2.87750656
82	apoptotic cell clearance (GO:0043277)	2.86793220
83	regulation of apoptotic cell clearance (GO:2000425)	2.86238838
84	protein-lipid complex assembly (GO:0065005)	2.85592809
85	regulation of guanylate cyclase activity (GO:0031282)	2.84284246
86	indole-containing compound catabolic process (GO:0042436)	2.82637275
87	indolalkylamine catabolic process (GO:0046218)	2.82637275
88	tryptophan catabolic process (GO:0006569)	2.82637275
89	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.82374017
90	hormone catabolic process (GO:0042447)	2.82013256
91	adhesion of symbiont to host (GO:0044406)	2.80869044
92	acute inflammatory response (GO:0002526)	2.79561890
93	sphingolipid catabolic process (GO:0030149)	2.78989214
94	cellular response to ethanol (GO:0071361)	2.77803433
95	negative regulation of hemostasis (GO:1900047)	2.75741742
96	negative regulation of blood coagulation (GO:0030195)	2.75741742
97	bile acid biosynthetic process (GO:0006699)	2.73711384
98	alkaloid metabolic process (GO:0009820)	2.72426384
99	negative regulation of coagulation (GO:0050819)	2.72422965
100	* cellular response to zinc ion (GO:0071294)	12.6502014

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.19386458
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.79218210
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.72719936
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.56873965
5	* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	3.44821036
6	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.35593990
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.00897583
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.99686797
9	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.91388592
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.83715666
11	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.73130673
12	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.62370830
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.32864119
14	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.17561878
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.17045073
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.13665518
17	IRF8_27001747_Chip-Seq_BMDM_Mouse	2.09478914
18	LXR_22292898_ChIP-Seq_THP-1_Human	2.07354671
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.98416876
20	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.92553188
21	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.89198844
22	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.88757659
23	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.88374574
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.85683108
25	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.81944504
26	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.74204004
27	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.62944001
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.61051173
29	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.59913014
30	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.59563153
31	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.53213721
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.51745785
33	* SOX2_20726797_ChIP-Seq_SW620_Human	1.43589982
34	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.39225184
35	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.38814977
36	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.38063946
37	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.35753156
38	VDR_24763502_ChIP-Seq_THP-1_Human	1.33950850
39	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.33612756
40	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.33390822
41	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.32817323
42	BCL6_27268052_Chip-Seq_Bcells_Human	1.32811086
43	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.31837012
44	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.31122345
45	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.30443689
46	GATA4_25053715_ChIP-Seq_YYC3_Human	1.29996834
47	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.28370421
48	SA1_27219007_Chip-Seq_Bcells_Human	1.27860660
49	GATA6_25053715_ChIP-Seq_YYC3_Human	1.23942683
50	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.22104751
51	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.20622698
52	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18664619
53	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.16954301
54	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.16346671
55	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.15844290
56	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.15572276
57	GATA1_22025678_ChIP-Seq_K562_Human	1.13572579
58	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.12133105
59	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.10158713
60	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.09935573
61	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.09401070
62	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.08892178
63	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08483981
64	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.08199731
65	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.07938519
66	RACK7_27058665_Chip-Seq_MCF-7_Human	1.07059366
67	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.06433798
68	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.06399455
69	STAT1_20625510_ChIP-Seq_HELA_Human	1.05546069
70	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05084991
71	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.04793307
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.04020216
73	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.03102794
74	EGR1_19032775_ChIP-ChIP_M12_Human	1.00858154
75	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.00377140
76	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.00173450
77	SPI1_23547873_ChIP-Seq_NB4_Human	0.98003060
78	VDR_24787735_ChIP-Seq_THP-1_Human	0.97659654
79	GATA1_19941826_ChIP-Seq_K562_Human	0.96985595
80	SPI1_23127762_ChIP-Seq_K562_Human	0.96815324
81	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.96497439
82	CLOCK_20551151_ChIP-Seq_293T_Human	0.95249761
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.94784374
84	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94370228
85	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.93334383
86	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.92926382
87	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.92795860
88	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.92716675
89	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.92440836
90	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.91834310
91	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.91371588
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91005129
93	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.90476768
94	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.89451484
95	VDR_21846776_ChIP-Seq_THP-1_Human	0.89421568
96	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.88631057
97	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.88236324
98	PHF8_20622854_ChIP-Seq_HELA_Human	0.87920327
99	* YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87766614
100	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.86438818

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.33645939
2	MP0005360_urolithiasis	5.03376542
3	MP0009840_abnormal_foam_cell	4.88656474
4	MP0005365_abnormal_bile_salt	4.04582130
5	MP0003195_calcinosis	3.52460175
6	MP0005085_abnormal_gallbladder_physiolo	3.48071318
7	MP0003806_abnormal_nucleotide_metabolis	3.02650611
8	MP0001666_abnormal_nutrient_absorption	3.01369023
9	MP0003191_abnormal_cellular_cholesterol	2.92098072
10	MP0009785_altered_susceptibility_to	2.85653327
11	MP0008875_abnormal_xenobiotic_pharmacok	2.77940154
12	MP0004019_abnormal_vitamin_homeostasis	2.54912018
13	MP0003436_decreased_susceptibility_to	2.46018521
14	MP0009764_decreased_sensitivity_to	2.20799709
15	MP0005058_abnormal_lysosome_morphology	2.15991146
16	MP0002148_abnormal_hypersensitivity_rea	2.12049132
17	MP0010329_abnormal_lipoprotein_level	2.05138160
18	MP0002837_dystrophic_cardiac_calcinosis	2.02010159
19	MP0002138_abnormal_hepatobiliary_system	2.00148828
20	MP0003183_abnormal_peptide_metabolism	1.89956321
21	MP0005332_abnormal_amino_acid	1.88778768
22	MP0003075_altered_response_to	1.88349358
23	MP0009278_abnormal_bone_marrow	1.85204885
24	MP0000343_altered_response_to	1.82305511
25	MP0005167_abnormal_blood-brain_barrier	1.79854401
26	MP0010155_abnormal_intestine_physiology	1.74992841
27	MP0000604_amyloidosis	1.73409576
28	MP0002419_abnormal_innate_immunity	1.71385352
29	MP0005166_decreased_susceptibility_to	1.67592273
30	MP0005025_abnormal_response_to	1.56913962
31	MP0002254_reproductive_system_inflammat	1.53179199
32	MP0006082_CNS_inflammation	1.51375104
33	MP0001853_heart_inflammation	1.49829730
34	MP0001845_abnormal_inflammatory_respons	1.43421674
35	MP0008469_abnormal_protein_level	1.42017378
36	MP0001764_abnormal_homeostasis	1.40713693
37	MP0001533_abnormal_skeleton_physiology	1.38651588
38	MP0003303_peritoneal_inflammation	1.37438078
39	MP0003868_abnormal_feces_composition	1.35609942
40	MP0008260_abnormal_autophagy	1.33825327
41	MP0001790_abnormal_immune_system	1.31686064
42	MP0005387_immune_system_phenotype	1.31686064
43	MP0002998_abnormal_bone_remodeling	1.30612228
44	MP0000609_abnormal_liver_physiology	1.29971332
45	MP0009643_abnormal_urine_homeostasis	1.25418160
46	MP0002118_abnormal_lipid_homeostasis	1.23074307
47	MP0005000_abnormal_immune_tolerance	1.21715659
48	MP0003252_abnormal_bile_duct	1.20262358
49	MP0003172_abnormal_lysosome_physiology	1.19880977
50	MP0004264_abnormal_extraembryonic_tissu	1.16655237
51	MP0003300_gastrointestinal_ulcer	1.16050876
52	MP0005397_hematopoietic_system_phenotyp	1.12944074
53	MP0001545_abnormal_hematopoietic_system	1.12944074
54	MP0009765_abnormal_xenobiotic_induced	1.12757398
55	MP0005319_abnormal_enzyme/_coenzyme	1.12497411
56	MP0003690_abnormal_glial_cell	1.08394369
57	MP0005670_abnormal_white_adipose	1.07746677
58	MP0004510_myositis	1.07382991
59	MP0005636_abnormal_mineral_homeostasis	1.06627534
60	MP0010234_abnormal_vibrissa_follicle	1.06276986
61	MP0009763_increased_sensitivity_to	1.04587335
62	MP0005584_abnormal_enzyme/coenzyme_acti	1.03565022
63	MP0005023_abnormal_wound_healing	1.01822044
64	MP0003186_abnormal_redox_activity	1.01226652
65	MP0003329_amyloid_beta_deposits	0.96092901
66	MP0003453_abnormal_keratinocyte_physiol	0.94605252
67	MP0003448_altered_tumor_morphology	0.94427806
68	MP0005671_abnormal_response_to	0.93085508
69	MP0005451_abnormal_body_composition	0.92855680
70	MP0002452_abnormal_antigen_presenting	0.91405901
71	MP0001849_ear_inflammation	0.88058785
72	MP0000858_altered_metastatic_potential	0.86977966
73	MP0000678_abnormal_parathyroid_gland	0.85720133
74	MP0001835_abnormal_antigen_presentation	0.85308150
75	MP0008874_decreased_physiological_sensi	0.85053484
76	MP0005464_abnormal_platelet_physiology	0.84334482
77	MP0003656_abnormal_erythrocyte_physiolo	0.84253297
78	MP0002723_abnormal_immune_serum	0.81750403
79	MP0000249_abnormal_blood_vessel	0.80038120
80	MP0000685_abnormal_immune_system	0.76354064
81	MP0000920_abnormal_myelination	0.76104890
82	MP0003638_abnormal_response/metabolism_	0.75483230
83	MP0009333_abnormal_splenocyte_physiolog	0.75315771
84	MP0003879_abnormal_hair_cell	0.74518597
85	MP0001663_abnormal_digestive_system	0.72603901
86	MP0002136_abnormal_kidney_physiology	0.72446994
87	MP0009642_abnormal_blood_homeostasis	0.72177234
88	MP0005310_abnormal_salivary_gland	0.71963714
89	MP0003828_pulmonary_edema	0.71959891
90	MP0001800_abnormal_humoral_immune	0.71935859
91	MP0003724_increased_susceptibility_to	0.70109290
92	MP0005377_hearing/vestibular/ear_phenot	0.68664676
93	MP0003878_abnormal_ear_physiology	0.68664676
94	MP0002896_abnormal_bone_mineralization	0.68468518
95	MP0001756_abnormal_urination	0.66566622
96	MP0004947_skin_inflammation	0.66545048
97	MP0001819_abnormal_immune_cell	0.66539158
98	MP0004043_abnormal_pH_regulation	0.66167131
99	MP0004883_abnormal_blood_vessel	0.64974693
100	MP0000490_abnormal_crypts_of	0.64816448

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus (HP:0002725)	6.65197641
2	Complement deficiency (HP:0004431)	6.17708877
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.72099686
4	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.41352397
5	Abnormality of complement system (HP:0005339)	5.08175720
6	Malnutrition (HP:0004395)	4.96231841
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.75227810
8	Xanthomatosis (HP:0000991)	4.75002423
9	Recurrent gram-negative bacterial infections (HP:0005420)	4.66641721
10	Glomerulonephritis (HP:0000099)	4.59419763
11	Hypobetalipoproteinemia (HP:0003563)	4.14832399
12	Hydroxyprolinuria (HP:0003080)	3.72998404
13	Abnormality of proline metabolism (HP:0010907)	3.72998404
14	Prolonged partial thromboplastin time (HP:0003645)	3.62782220
15	Abnormality of pyrimidine metabolism (HP:0004353)	3.60390953
16	Abnormality of glycolipid metabolism (HP:0010969)	3.55421522
17	Abnormality of liposaccharide metabolism (HP:0010968)	3.55421522
18	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.55421522
19	Deep venous thrombosis (HP:0002625)	3.50402977
20	Eczematoid dermatitis (HP:0000976)	3.47113967
21	Fat malabsorption (HP:0002630)	3.38329638
22	Metaphyseal irregularity (HP:0003025)	3.15871979
23	Abnormality of macrophages (HP:0004311)	3.12802129
24	Steatorrhea (HP:0002570)	3.10621195
25	Nephritis (HP:0000123)	3.05259357
26	Nausea (HP:0002018)	3.04276763
27	Recurrent abscess formation (HP:0002722)	3.00521503
28	Generalized aminoaciduria (HP:0002909)	2.94502691
29	Widely patent fontanelles and sutures (HP:0004492)	2.88644567
30	Hypophosphatemia (HP:0002148)	2.85945810
31	Increased serum ferritin (HP:0003281)	2.84515467
32	Recurrent bacterial skin infections (HP:0005406)	2.76263233
33	Joint hemorrhage (HP:0005261)	2.66310488
34	Abnormal hemoglobin (HP:0011902)	2.63288533
35	Conjugated hyperbilirubinemia (HP:0002908)	2.63236667
36	Vacuolated lymphocytes (HP:0001922)	2.62658691
37	Hyperlipoproteinemia (HP:0010980)	2.62017123
38	Hypolipoproteinemia (HP:0010981)	2.56343263
39	Increased cerebral lipofuscin (HP:0011813)	2.53392352
40	Abnormality of iron homeostasis (HP:0011031)	2.50550295
41	Protuberant abdomen (HP:0001538)	2.47944185
42	Intrahepatic cholestasis (HP:0001406)	2.44734208
43	Thin bony cortex (HP:0002753)	2.41166528
44	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.40132425
45	Symptomatic seizures (HP:0011145)	2.39654664
46	Hyperammonemia (HP:0001987)	2.38997828
47	Retinal atrophy (HP:0001105)	2.36972722
48	Delayed epiphyseal ossification (HP:0002663)	2.36945277
49	Abnormality of nucleobase metabolism (HP:0010932)	2.35701446
50	Purpura (HP:0000979)	2.34523071
51	Abnormality of glycine metabolism (HP:0010895)	2.31913876
52	Abnormality of serine family amino acid metabolism (HP:0010894)	2.31913876
53	Loss of speech (HP:0002371)	2.31702175
54	Pancreatitis (HP:0001733)	2.31429193
55	Amyloidosis (HP:0011034)	2.30828047
56	Hemorrhage of the eye (HP:0011885)	2.30468644
57	Abnormal enzyme/coenzyme activity (HP:0012379)	2.30167607
58	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.25419175
59	Abnormality of alkaline phosphatase activity (HP:0004379)	2.25259018
60	Elevated alkaline phosphatase (HP:0003155)	2.25197419
61	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.25036422
62	Hyperglycinuria (HP:0003108)	2.24343285
63	Metabolic alkalosis (HP:0200114)	2.23193220
64	Alkalosis (HP:0001948)	2.21489076
65	Bone pain (HP:0002653)	2.20019411
66	Abnormality of vitamin metabolism (HP:0100508)	2.19775463
67	Dysostosis multiplex (HP:0000943)	2.18508832
68	Abnormality of transition element cation homeostasis (HP:0011030)	2.18228777
69	Visceral angiomatosis (HP:0100761)	2.16965236
70	Confusion (HP:0001289)	2.16807445
71	Mutism (HP:0002300)	2.16045341
72	Petechiae (HP:0000967)	2.14902102
73	Myocardial infarction (HP:0001658)	2.14522941
74	Abnormality of vitamin B metabolism (HP:0004340)	2.11755703
75	Gingivitis (HP:0000230)	2.10741030
76	Neurofibrillary tangles (HP:0002185)	2.09305529
77	Abdominal distention (HP:0003270)	2.08244765
78	Spontaneous hematomas (HP:0007420)	2.07778684
79	Irritability (HP:0000737)	2.07609577
80	Pathologic fracture (HP:0002756)	2.06693549
81	Rickets (HP:0002748)	2.06489734
82	Premature loss of primary teeth (HP:0006323)	2.05860605
83	Ileus (HP:0002595)	2.04977690
84	Abnormality of urine glucose concentration (HP:0011016)	2.04475313
85	Glycosuria (HP:0003076)	2.04475313
86	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.04391562
87	Nephrolithiasis (HP:0000787)	2.03044814
88	Hematochezia (HP:0002573)	2.02644698
89	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.01411677
90	Bone cyst (HP:0012062)	2.00628396
91	Axonal loss (HP:0003447)	1.98828545
92	Hemangiomatosis (HP:0007461)	1.94749062
93	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.93334193
94	Abnormality of polysaccharide metabolism (HP:0011012)	1.93334193
95	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.93334193
96	Chronic diarrhea (HP:0002028)	1.91805448
97	Abnormality of the costochondral junction (HP:0000919)	1.90507664
98	Hyperactive renin-angiotensin system (HP:0000841)	1.89916231
99	Epidermoid cyst (HP:0200040)	1.88975326
100	Hypoalphalipoproteinemia (HP:0003233)	1.88899110

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	5.16169115
2	ERN1	4.29361839
3	NME2	3.76340142
4	TGFBR2	3.00397375
5	BLK	2.86328938
6	RIPK4	2.72418635
7	DDR2	2.66874448
8	MATK	2.60361740
9	PRKG2	2.48480270
10	TYK2	2.35498850
11	IRAK3	2.16597430
12	TESK1	2.11197282
13	ABL2	1.92857069
14	RIPK1	1.90518967
15	CSK	1.84585789
16	FGR	1.81967479
17	MAP3K11	1.79754613
18	MAP3K3	1.79655718
19	TESK2	1.64866597
20	MAP3K13	1.58014324
21	PDK2	1.54005841
22	CSF1R	1.49746254
23	OXSR1	1.44701723
24	MAP3K12	1.44124111
25	LMTK2	1.33048484
26	CDC42BPA	1.30156833
27	MAP3K1	1.29334774
28	TAOK1	1.28415196
29	LIMK1	1.27856531
30	MAP3K14	1.22198313
31	TAOK2	1.22087732
32	EPHB2	1.21617748
33	MAP2K6	1.20769017
34	GRK7	1.19938223
35	TBK1	1.17530924
36	PRPF4B	1.12349948
37	ARAF	1.11947604
38	FGFR4	1.10091652
39	PBK	1.08836738
40	MAP4K1	1.07991195
41	TGFBR1	1.07391417
42	DAPK2	1.02916274
43	PAK4	1.02638221
44	PDPK1	0.94942397
45	LYN	0.94492202
46	MST1R	0.92614937
47	KSR2	0.92338098
48	MAP3K2	0.87843787
49	IKBKB	0.84850946
50	CAMKK2	0.84576917
51	MST4	0.84496646
52	PRKAA2	0.84389802
53	IKBKE	0.80452992
54	ADRBK2	0.79034847
55	KDR	0.73383279
56	IRAK4	0.72907370
57	BCKDK	0.70553472
58	PRKACG	0.70235329
59	TYRO3	0.70050878
60	ZAP70	0.69575680
61	EPHA2	0.66602620
62	CAMK1D	0.66212938
63	BMX	0.65242015
64	RPS6KC1	0.64728749
65	RPS6KL1	0.64728749
66	MAP2K3	0.64268513
67	TNIK	0.61449544
68	RPS6KA2	0.60859178
69	PTK6	0.59894994
70	JAK3	0.56033322
71	PDK1	0.51742129
72	MYLK	0.51157911
73	RPS6KA6	0.50281579
74	MAP3K8	0.49741467
75	PRKCA	0.49266498
76	PRKCD	0.47835954
77	JAK1	0.45879410
78	JAK2	0.45740837
79	SMG1	0.45458814
80	SRC	0.43377361
81	STK16	0.42769447
82	PDGFRA	0.42466153
83	GRK6	0.41826362
84	SYK	0.38302972
85	PRKCZ	0.37390702
86	IGF1R	0.37111385
87	EPHA3	0.37057330
88	EEF2K	0.36933207
89	MAPK12	0.36429907
90	CAMK2G	0.35587691
91	MAP2K4	0.35091576
92	LCK	0.33623110
93	STK24	0.33352990
94	PRKCG	0.33179593
95	MAPKAPK3	0.31568570
96	BRAF	0.31511726
97	MAP2K2	0.31149106
98	ALK	0.29899158
99	KIT	0.29564417
100	FYN	0.29534395

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Mineral absorption_Homo sapiens_hsa04978	4.00272847
2	Caffeine metabolism_Homo sapiens_hsa00232	3.19522801
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.95789619
4	Complement and coagulation cascades_Homo sapiens_hsa04610	2.57248728
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.50333209
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.44750641
7	Fat digestion and absorption_Homo sapiens_hsa04975	2.44203183
8	Retinol metabolism_Homo sapiens_hsa00830	2.42814672
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.26905627
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.26738384
11	Histidine metabolism_Homo sapiens_hsa00340	2.26328115
12	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.23935847
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.17743365
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.14806075
15	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.14161090
16	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.03748277
17	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.00055601
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.97371704
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.93554133
20	Fatty acid degradation_Homo sapiens_hsa00071	1.90454692
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.80811940
22	Renin-angiotensin system_Homo sapiens_hsa04614	1.78399939
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.75039424
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.73353773
25	Sulfur metabolism_Homo sapiens_hsa00920	1.69896935
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67139829
27	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.65443970
28	Other glycan degradation_Homo sapiens_hsa00511	1.54551617
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.53565195
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.51877589
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.48193929
32	Tyrosine metabolism_Homo sapiens_hsa00350	1.43899350
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.38123268
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.36711040
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.35718199
36	Bile secretion_Homo sapiens_hsa04976	1.35260982
37	Prion diseases_Homo sapiens_hsa05020	1.33849991
38	Pertussis_Homo sapiens_hsa05133	1.31328925
39	Galactose metabolism_Homo sapiens_hsa00052	1.31111990
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.25147641
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.17434166
42	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.13125155
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.12485770
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11906092
45	Lysosome_Homo sapiens_hsa04142	1.09665051
46	Protein digestion and absorption_Homo sapiens_hsa04974	1.07552835
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.00075585
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.96672550
49	Glutathione metabolism_Homo sapiens_hsa00480	0.82224012
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79751706
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78526312
52	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.75980997
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74552543
54	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73784609
55	Legionellosis_Homo sapiens_hsa05134	0.70967295
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.70735714
57	Carbon metabolism_Homo sapiens_hsa01200	0.70215982
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69905239
59	TNF signaling pathway_Homo sapiens_hsa04668	0.69221372
60	Peroxisome_Homo sapiens_hsa04146	0.68809619
61	Pentose phosphate pathway_Homo sapiens_hsa00030	0.68198650
62	Asthma_Homo sapiens_hsa05310	0.66394587
63	Folate biosynthesis_Homo sapiens_hsa00790	0.64680631
64	Tuberculosis_Homo sapiens_hsa05152	0.63840458
65	Osteoclast differentiation_Homo sapiens_hsa04380	0.63618555
66	Phagosome_Homo sapiens_hsa04145	0.62668582
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.60869269
68	Leishmaniasis_Homo sapiens_hsa05140	0.59647260
69	Butanoate metabolism_Homo sapiens_hsa00650	0.59167837
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.59107268
71	Salmonella infection_Homo sapiens_hsa05132	0.58144299
72	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.57387954
73	Malaria_Homo sapiens_hsa05144	0.55047078
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54654598
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.51724695
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51366375
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49726518
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48890392
79	Amoebiasis_Homo sapiens_hsa05146	0.44008478
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43405180
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42686872
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.41561707
83	Chemokine signaling pathway_Homo sapiens_hsa04062	0.41017679
84	Pancreatic secretion_Homo sapiens_hsa04972	0.40062582
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38752387
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37245140
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.35021584
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34691281
89	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.34644034
90	Sulfur relay system_Homo sapiens_hsa04122	0.34109638
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.34045744
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.33227009
93	Bladder cancer_Homo sapiens_hsa05219	0.32467873
94	Allograft rejection_Homo sapiens_hsa05330	0.32278078
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.31871351
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.31679861
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31021074
98	Metabolic pathways_Homo sapiens_hsa01100	0.30350129
99	African trypanosomiasis_Homo sapiens_hsa05143	0.27186913
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.23137260

MT1G

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »