ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fat-soluble vitamin biosynthetic process (GO:0042362)	5.96521224
2	eosinophil chemotaxis (GO:0048245)	5.91266979
3	regulation of mononuclear cell migration (GO:0071675)	5.67289675
4	regulation of macrophage chemotaxis (GO:0010758)	5.29341951
5	eosinophil migration (GO:0072677)	5.23917135
6	* response to zinc ion (GO:0010043)	5.15622037
7	positive regulation of lipoprotein lipase activity (GO:0051006)	4.90885101
8	positive regulation of triglyceride lipase activity (GO:0061365)	4.90885101
9	negative regulation of myeloid cell apoptotic process (GO:0033033)	4.79936151
10	angiotensin maturation (GO:0002003)	4.66746786
11	glycosphingolipid catabolic process (GO:0046479)	4.42226318
12	apoptotic cell clearance (GO:0043277)	4.41726366
13	* response to cadmium ion (GO:0046686)	4.27407617
14	neutrophil activation involved in immune response (GO:0002283)	4.24393413
15	epoxygenase P450 pathway (GO:0019373)	4.23905291
16	glycolipid catabolic process (GO:0019377)	4.18168312
17	monocyte chemotaxis (GO:0002548)	4.10650699
18	barbed-end actin filament capping (GO:0051016)	4.05659491
19	phospholipid efflux (GO:0033700)	4.05529822
20	peptide catabolic process (GO:0043171)	3.96562458
21	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.89270967
22	negative regulation of interleukin-12 production (GO:0032695)	3.89005491
23	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.88029954
24	cellular response to thyroid hormone stimulus (GO:0097067)	3.84583593
25	cellular response to ethanol (GO:0071361)	3.83353530
26	response to peptidoglycan (GO:0032494)	3.82045548
27	negative regulation of cholesterol transport (GO:0032375)	3.73781389
28	negative regulation of sterol transport (GO:0032372)	3.73781389
29	respiratory burst (GO:0045730)	3.70626166
30	cellular extravasation (GO:0045123)	3.61394623
31	regulation of cholesterol esterification (GO:0010872)	3.58778178
32	macrophage differentiation (GO:0030225)	3.57408654
33	ceramide catabolic process (GO:0046514)	3.50966403
34	membrane lipid catabolic process (GO:0046466)	3.44512265
35	response to thyroid hormone (GO:0097066)	3.35464283
36	monocyte differentiation (GO:0030224)	3.29113869
37	regulation of lymphocyte chemotaxis (GO:1901623)	3.29004036
38	sphingolipid catabolic process (GO:0030149)	3.27123857
39	regulation of vitamin metabolic process (GO:0030656)	3.26987617
40	fructose metabolic process (GO:0006000)	3.26239947
41	vitamin biosynthetic process (GO:0009110)	3.24833497
42	granulocyte chemotaxis (GO:0071621)	3.24627805
43	lipopolysaccharide-mediated signaling pathway (GO:0031663)	3.24495819
44	oligosaccharide catabolic process (GO:0009313)	3.21309697
45	regulation of podosome assembly (GO:0071801)	3.17643868
46	adhesion of symbiont to host cell (GO:0044650)	3.17566114
47	virion attachment to host cell (GO:0019062)	3.17566114
48	omega-hydroxylase P450 pathway (GO:0097267)	3.16587387
49	granulocyte migration (GO:0097530)	3.12541117
50	response to copper ion (GO:0046688)	3.11105964
51	regulation of cholesterol homeostasis (GO:2000188)	3.06079423
52	regulation of vitamin D biosynthetic process (GO:0060556)	3.04629888
53	regulation of triglyceride catabolic process (GO:0010896)	3.03659323
54	response to magnesium ion (GO:0032026)	3.03173177
55	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.99792784
56	modulation by symbiont of host immune response (GO:0052553)	2.99792784
57	positive regulation by symbiont of host defense response (GO:0052509)	2.99792784
58	modulation by symbiont of host defense response (GO:0052031)	2.99792784
59	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.99792784
60	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.99792784
61	intracellular pH reduction (GO:0051452)	2.99194113
62	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.98055923
63	glucose 6-phosphate metabolic process (GO:0051156)	2.95430917
64	complement activation, alternative pathway (GO:0006957)	2.94759209
65	pH reduction (GO:0045851)	2.93866872
66	cholesterol efflux (GO:0033344)	2.92422245
67	positive regulation of cholesterol efflux (GO:0010875)	2.92383143
68	immunoglobulin mediated immune response (GO:0016064)	2.92248201
69	positive regulation of cellular amide metabolic process (GO:0034250)	2.88366360
70	NIK/NF-kappaB signaling (GO:0038061)	2.87265568
71	protein-lipid complex remodeling (GO:0034368)	2.85911568
72	macromolecular complex remodeling (GO:0034367)	2.85911568
73	plasma lipoprotein particle remodeling (GO:0034369)	2.85911568
74	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.84152692
75	positive regulation of triglyceride metabolic process (GO:0090208)	2.83479937
76	decidualization (GO:0046697)	2.79658367
77	phagosome maturation (GO:0090382)	2.78826116
78	L-alpha-amino acid transmembrane transport (GO:1902475)	2.78257067
79	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.78214316
80	neutrophil chemotaxis (GO:0030593)	2.77882874
81	NADH metabolic process (GO:0006734)	2.76826600
82	neutrophil migration (GO:1990266)	2.73633095
83	hydrogen peroxide biosynthetic process (GO:0050665)	2.72601233
84	acute-phase response (GO:0006953)	2.70451551
85	adhesion of symbiont to host (GO:0044406)	2.67176386
86	lymphocyte chemotaxis (GO:0048247)	2.65513150
87	regulation of lymphocyte migration (GO:2000401)	2.64783352
88	glial cell migration (GO:0008347)	2.64476456
89	regulation of apoptotic cell clearance (GO:2000425)	2.60323632
90	urea metabolic process (GO:0019627)	2.60139551
91	low-density lipoprotein particle remodeling (GO:0034374)	2.59097492
92	negative regulation of leukocyte chemotaxis (GO:0002689)	2.59081067
93	macrophage activation involved in immune response (GO:0002281)	2.58027448
94	granulocyte activation (GO:0036230)	2.57715953
95	vitamin D metabolic process (GO:0042359)	2.56047813
96	positive regulation of phagocytosis (GO:0050766)	2.54895576
97	positive regulation of leukocyte chemotaxis (GO:0002690)	2.53905601
98	nitrogen cycle metabolic process (GO:0071941)	2.53689074
99	* cellular response to zinc ion (GO:0071294)	15.0565321
100	* cellular response to cadmium ion (GO:0071276)	10.9543438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	4.78821725
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.16541202
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.74253443
4	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.06654237
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.80974418
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.73473226
7	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.71172930
8	IRF8_27001747_Chip-Seq_BMDM_Mouse	2.64274692
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54090656
10	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.50956693
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.40788528
12	LXR_22292898_ChIP-Seq_THP-1_Human	2.30701739
13	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.30682806
14	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	2.27366402
15	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.15874004
16	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.07253589
17	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.01199696
18	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.96837663
19	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.92937148
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.90706395
21	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.90384379
22	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.89391100
23	VDR_24763502_ChIP-Seq_THP-1_Human	1.86222045
24	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.77724811
25	VDR_21846776_ChIP-Seq_THP-1_Human	1.75371309
26	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.72127863
27	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.71935713
28	BCOR_27268052_Chip-Seq_Bcells_Human	1.70914821
29	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.61560730
30	* SPI1_23547873_ChIP-Seq_NB4_Human	1.60856098
31	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.59233249
32	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.59172469
33	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.52258824
34	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.49889592
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.49531157
36	SPI1_23127762_ChIP-Seq_K562_Human	1.49343176
37	BCL6_27268052_Chip-Seq_Bcells_Human	1.48242130
38	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.48048747
39	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.47103679
40	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.45915834
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.43052766
42	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.40244136
43	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.38586954
44	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.38322157
45	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.38177568
46	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.38043946
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.33243998
48	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.28892998
49	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.27975301
50	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.26210594
51	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.25571591
52	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.24826693
53	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.24372566
54	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.22714696
55	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.22246648
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22173312
57	SA1_27219007_Chip-Seq_Bcells_Human	1.21353642
58	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.20345740
59	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.19369770
60	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.19287819
61	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.16761252
62	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.16503740
63	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.16126753
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14102937
65	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.13587778
66	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.13521321
67	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.12825762
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.12800263
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.12232941
70	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.12178916
71	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.12024985
72	RACK7_27058665_Chip-Seq_MCF-7_Human	1.11846660
73	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.09402203
74	STAT1_20625510_ChIP-Seq_HELA_Human	1.09276081
75	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.07861323
76	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.06662093
77	VDR_24787735_ChIP-Seq_THP-1_Human	1.06124044
78	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.05994804
79	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.05413041
80	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.04888417
81	PHF8_20622854_ChIP-Seq_HELA_Human	1.03944526
82	PU_27001747_Chip-Seq_BMDM_Mouse	1.03386796
83	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03110313
84	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.03079413
85	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.02383956
86	NANOG_18692474_ChIP-Seq_MEFs_Mouse	1.02031097
87	CTCF_20526341_ChIP-Seq_ESCs_Human	1.01005359
88	GATA1_22025678_ChIP-Seq_K562_Human	1.00493844
89	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.00408602
90	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.00387488
91	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.00009393
92	P68_20966046_ChIP-Seq_HELA_Human	0.97875547
93	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.96137547
94	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.94962853
95	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.94807855
96	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.94335207
97	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.94254091
98	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.93983028
99	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.92904852
100	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92732494

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	5.27103180
2	MP0002139_abnormal_hepatobiliary_system	4.55049421
3	MP0003806_abnormal_nucleotide_metabolis	3.47270890
4	MP0009785_altered_susceptibility_to	3.37480390
5	MP0009278_abnormal_bone_marrow	3.30867105
6	MP0003436_decreased_susceptibility_to	3.29546256
7	MP0005058_abnormal_lysosome_morphology	3.06768978
8	MP0003191_abnormal_cellular_cholesterol	3.03297215
9	MP0003195_calcinosis	2.94374994
10	MP0002148_abnormal_hypersensitivity_rea	2.92964591
11	MP0002837_dystrophic_cardiac_calcinosis	2.91431806
12	MP0005365_abnormal_bile_salt	2.85128268
13	MP0005360_urolithiasis	2.73495595
14	MP0005167_abnormal_blood-brain_barrier	2.62177911
15	MP0009764_decreased_sensitivity_to	2.53586597
16	MP0000343_altered_response_to	2.50494088
17	MP0002419_abnormal_innate_immunity	2.36675290
18	MP0003075_altered_response_to	2.25211217
19	MP0001853_heart_inflammation	2.20889482
20	MP0002254_reproductive_system_inflammat	2.14743132
21	MP0000604_amyloidosis	2.09234708
22	MP0006082_CNS_inflammation	2.00270078
23	MP0005025_abnormal_response_to	1.95759113
24	MP0004019_abnormal_vitamin_homeostasis	1.95022283
25	MP0008260_abnormal_autophagy	1.91246124
26	MP0001533_abnormal_skeleton_physiology	1.85103628
27	MP0005085_abnormal_gallbladder_physiolo	1.84730655
28	MP0002998_abnormal_bone_remodeling	1.82188393
29	MP0003303_peritoneal_inflammation	1.77161071
30	MP0003183_abnormal_peptide_metabolism	1.77064678
31	MP0001790_abnormal_immune_system	1.75198570
32	MP0005387_immune_system_phenotype	1.75198570
33	MP0005000_abnormal_immune_tolerance	1.73667332
34	MP0003172_abnormal_lysosome_physiology	1.70034966
35	MP0005397_hematopoietic_system_phenotyp	1.68365565
36	MP0001545_abnormal_hematopoietic_system	1.68365565
37	MP0001845_abnormal_inflammatory_respons	1.57531038
38	MP0001666_abnormal_nutrient_absorption	1.55277569
39	MP0008469_abnormal_protein_level	1.52031710
40	MP0005671_abnormal_response_to	1.50576057
41	MP0005166_decreased_susceptibility_to	1.48696616
42	MP0010155_abnormal_intestine_physiology	1.47870265
43	MP0004510_myositis	1.43050622
44	MP0002452_abnormal_antigen_presenting	1.39775191
45	MP0008875_abnormal_xenobiotic_pharmacok	1.39416695
46	MP0003453_abnormal_keratinocyte_physiol	1.38201520
47	MP0003300_gastrointestinal_ulcer	1.32777200
48	MP0003828_pulmonary_edema	1.31789118
49	MP0001849_ear_inflammation	1.31344225
50	MP0003448_altered_tumor_morphology	1.28734434
51	MP0001835_abnormal_antigen_presentation	1.28716833
52	MP0003329_amyloid_beta_deposits	1.27648894
53	MP0009765_abnormal_xenobiotic_induced	1.26622387
54	MP0000858_altered_metastatic_potential	1.26130753
55	MP0005023_abnormal_wound_healing	1.23212083
56	MP0005464_abnormal_platelet_physiology	1.22912130
57	MP0005310_abnormal_salivary_gland	1.22858426
58	MP0003690_abnormal_glial_cell	1.19902246
59	MP0002723_abnormal_immune_serum	1.17935677
60	MP0010329_abnormal_lipoprotein_level	1.16663051
61	MP0002138_abnormal_hepatobiliary_system	1.15420848
62	MP0009333_abnormal_splenocyte_physiolog	1.12509135
63	MP0000685_abnormal_immune_system	1.09526383
64	MP0005332_abnormal_amino_acid	1.08929851
65	MP0001819_abnormal_immune_cell	1.07084799
66	MP0001764_abnormal_homeostasis	1.06794849
67	MP0009763_increased_sensitivity_to	1.05461706
68	MP0002420_abnormal_adaptive_immunity	1.04407375
69	MP0005451_abnormal_body_composition	1.04211201
70	MP0003186_abnormal_redox_activity	1.03892676
71	MP0008874_decreased_physiological_sensi	1.01592262
72	MP0003656_abnormal_erythrocyte_physiolo	1.01441520
73	MP0001800_abnormal_humoral_immune	1.01220191
74	MP0000920_abnormal_myelination	0.99290776
75	MP0005319_abnormal_enzyme/_coenzyme	0.99238771
76	MP0004233_abnormal_muscle_weight	0.96122393
77	MP0000609_abnormal_liver_physiology	0.91299606
78	MP0005257_abnormal_intraocular_pressure	0.88045984
79	MP0005595_abnormal_vascular_smooth	0.87634561
80	MP0002405_respiratory_system_inflammati	0.86321181
81	MP0004883_abnormal_blood_vessel	0.86036892
82	MP0003795_abnormal_bone_structure	0.85846277
83	MP0004947_skin_inflammation	0.85630247
84	MP0002896_abnormal_bone_mineralization	0.82390121
85	MP0004264_abnormal_extraembryonic_tissu	0.81215684
86	MP0002277_abnormal_respiratory_mucosa	0.79118955
87	MP0005584_abnormal_enzyme/coenzyme_acti	0.78976695
88	MP0009643_abnormal_urine_homeostasis	0.78105948
89	MP0000249_abnormal_blood_vessel	0.75170584
90	MP0000750_abnormal_muscle_regeneration	0.74319030
91	MP0000678_abnormal_parathyroid_gland	0.73257230
92	MP0003279_aneurysm	0.71930283
93	MP0003724_increased_susceptibility_to	0.70622738
94	MP0002118_abnormal_lipid_homeostasis	0.68866003
95	MP0005164_abnormal_response_to	0.67168707
96	MP0000490_abnormal_crypts_of	0.65748803
97	MP0005390_skeleton_phenotype	0.65031631
98	MP0002933_joint_inflammation	0.64259690
99	MP0003638_abnormal_response/metabolism_	0.62624538
100	MP0005636_abnormal_mineral_homeostasis	0.62138916

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus (HP:0002725)	5.83700566
2	Abnormality of glycolipid metabolism (HP:0010969)	5.40734815
3	Abnormality of liposaccharide metabolism (HP:0010968)	5.40734815
4	Abnormality of glycosphingolipid metabolism (HP:0004343)	5.40734815
5	Malnutrition (HP:0004395)	5.05909691
6	Recurrent gram-negative bacterial infections (HP:0005420)	4.91226576
7	Eczematoid dermatitis (HP:0000976)	4.68232438
8	Abnormality of macrophages (HP:0004311)	4.67584164
9	Recurrent bacterial skin infections (HP:0005406)	4.56284323
10	Recurrent abscess formation (HP:0002722)	4.54002757
11	Xanthomatosis (HP:0000991)	4.36272035
12	Complement deficiency (HP:0004431)	4.24791393
13	Metaphyseal irregularity (HP:0003025)	4.20108009
14	Glomerulonephritis (HP:0000099)	3.99338563
15	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.89795830
16	Increased cerebral lipofuscin (HP:0011813)	3.80492954
17	Vacuolated lymphocytes (HP:0001922)	3.72983841
18	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.70735491
19	Increased serum ferritin (HP:0003281)	3.69124091
20	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.52016345
21	Abnormality of complement system (HP:0005339)	3.45257518
22	Loss of speech (HP:0002371)	3.25548994
23	Mutism (HP:0002300)	3.17385177
24	Abnormality of pyrimidine metabolism (HP:0004353)	3.13290713
25	Nausea (HP:0002018)	3.12887496
26	Abnormality of proline metabolism (HP:0010907)	3.07360620
27	Hydroxyprolinuria (HP:0003080)	3.07360620
28	Dysostosis multiplex (HP:0000943)	3.02979085
29	Neurofibrillary tangles (HP:0002185)	3.00996592
30	Abnormality of iron homeostasis (HP:0011031)	2.95167796
31	Retinal atrophy (HP:0001105)	2.94446148
32	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.92862714
33	Premature loss of primary teeth (HP:0006323)	2.87975690
34	Delayed epiphyseal ossification (HP:0002663)	2.79077549
35	Hypophosphatemia (HP:0002148)	2.78324359
36	Hematochezia (HP:0002573)	2.74511234
37	Mediastinal lymphadenopathy (HP:0100721)	2.74204720
38	Myocardial infarction (HP:0001658)	2.70729437
39	Spontaneous hematomas (HP:0007420)	2.67199720
40	Widely patent fontanelles and sutures (HP:0004492)	2.61089708
41	Thin bony cortex (HP:0002753)	2.58726670
42	Gingivitis (HP:0000230)	2.57671871
43	Chronic obstructive pulmonary disease (HP:0006510)	2.56084785
44	Obstructive lung disease (HP:0006536)	2.56084785
45	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.53202665
46	Abnormality of polysaccharide metabolism (HP:0011012)	2.53201476
47	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.53201476
48	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.53201476
49	Abnormality of transition element cation homeostasis (HP:0011030)	2.53184218
50	Progressive visual loss (HP:0000529)	2.53138303
51	Bone pain (HP:0002653)	2.51720926
52	Generalized aminoaciduria (HP:0002909)	2.51461083
53	Pathologic fracture (HP:0002756)	2.47809064
54	Petechiae (HP:0000967)	2.47347147
55	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.46563801
56	Amyloidosis (HP:0011034)	2.46557824
57	Protuberant abdomen (HP:0001538)	2.44536453
58	Recurrent skin infections (HP:0001581)	2.36627993
59	Conjunctival telangiectasia (HP:0000524)	2.34115534
60	Disinhibition (HP:0000734)	2.33736351
61	Nephritis (HP:0000123)	2.31933700
62	Purpura (HP:0000979)	2.31472637
63	Symptomatic seizures (HP:0011145)	2.31279494
64	Elevated alkaline phosphatase (HP:0003155)	2.27148410
65	Abnormality of alkaline phosphatase activity (HP:0004379)	2.24773035
66	Urinary glycosaminoglycan excretion (HP:0003541)	2.24200839
67	Mucopolysacchariduria (HP:0008155)	2.24200839
68	Abnormal enzyme/coenzyme activity (HP:0012379)	2.23775938
69	Axonal loss (HP:0003447)	2.22259129
70	Hypobetalipoproteinemia (HP:0003563)	2.11344285
71	Short femoral neck (HP:0100864)	2.07242545
72	Abnormality of the costochondral junction (HP:0000919)	2.03156535
73	Abnormal trabecular bone morphology (HP:0100671)	2.01714955
74	Autoimmune thrombocytopenia (HP:0001973)	2.01506520
75	Cerebral inclusion bodies (HP:0100314)	1.98943717
76	Visceral angiomatosis (HP:0100761)	1.97447610
77	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.96353989
78	Prolonged partial thromboplastin time (HP:0003645)	1.94636921
79	Dementia (HP:0000726)	1.94059621
80	Prolonged neonatal jaundice (HP:0006579)	1.93425310
81	Upper motor neuron abnormality (HP:0002127)	1.91534184
82	Cerebral hemorrhage (HP:0001342)	1.90680850
83	Hypertriglyceridemia (HP:0002155)	1.87629847
84	Bone cyst (HP:0012062)	1.83811491
85	Gastrointestinal stroma tumor (HP:0100723)	1.83051512
86	Hemoptysis (HP:0002105)	1.82425358
87	Wide cranial sutures (HP:0010537)	1.81191976
88	Pancreatitis (HP:0001733)	1.80038962
89	Hemangiomatosis (HP:0007461)	1.78456419
90	Irritability (HP:0000737)	1.78207520
91	Abnormality of the periventricular white matter (HP:0002518)	1.77301158
92	Abdominal distention (HP:0003270)	1.77231479
93	Multiple enchondromatosis (HP:0005701)	1.76639084
94	Abnormality of nucleobase metabolism (HP:0010932)	1.76312580
95	Flat occiput (HP:0005469)	1.76083471
96	Recurrent pneumonia (HP:0006532)	1.75603976
97	Esophageal varix (HP:0002040)	1.75539890
98	Fat malabsorption (HP:0002630)	1.74422098
99	Enlarged epiphyses (HP:0010580)	1.73589732
100	Urticaria (HP:0001025)	1.72970756

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.14739052
2	BLK	3.80758276
3	ACVR1B	3.72366294
4	TGFBR2	3.35852539
5	ERN1	3.32622516
6	RIPK4	2.92548288
7	MATK	2.78985657
8	PBK	2.61932547
9	DDR2	2.55140944
10	FGR	2.48825608
11	IRAK3	2.46331905
12	CSK	2.26694248
13	LMTK2	2.17627447
14	PRKG2	2.17373824
15	TYK2	2.07005267
16	TESK2	2.03691603
17	CSF1R	1.92093162
18	TGFBR1	1.67925860
19	TESK1	1.61177021
20	MAP3K14	1.59130080
21	TAOK2	1.55927408
22	GRK7	1.55286758
23	MAP3K11	1.54053913
24	ABL2	1.46258907
25	MAP3K13	1.44474678
26	SMG1	1.43505556
27	PDK2	1.39380590
28	TAOK1	1.37323104
29	MAP3K3	1.36017699
30	PAK4	1.34744839
31	PRPF4B	1.34680647
32	CDC42BPA	1.32608868
33	CAMK1D	1.32471238
34	LIMK1	1.24181274
35	MAP4K1	1.16235994
36	LYN	1.14959151
37	CAMKK2	1.10721232
38	EPHB2	1.09811841
39	ARAF	1.08719776
40	EEF2K	1.06686543
41	TBK1	1.05143133
42	BMX	1.01109101
43	IKBKB	0.99052378
44	MAP3K1	0.98029507
45	RPS6KL1	0.96126920
46	RPS6KC1	0.96126920
47	IRAK4	0.96035819
48	MAP2K3	0.94451818
49	BCKDK	0.93479795
50	RPS6KA2	0.90956220
51	RIPK1	0.86119336
52	TYRO3	0.85600038
53	KDR	0.84594848
54	MAP2K6	0.84447631
55	ZAP70	0.80694226
56	JAK3	0.78923934
57	OXSR1	0.77743581
58	RPS6KA6	0.77478129
59	ADRBK2	0.74728894
60	MAP3K8	0.74446040
61	IKBKE	0.70492429
62	PDPK1	0.68927176
63	ALK	0.63086481
64	KSR2	0.61951993
65	FES	0.60914588
66	DAPK2	0.58894711
67	TNIK	0.55325013
68	FGFR4	0.55313420
69	STK16	0.52760886
70	CDK19	0.51395368
71	SYK	0.49983101
72	LCK	0.46603021
73	PRKCD	0.41567131
74	PRKACG	0.37799762
75	PRKAA2	0.35771105
76	PAK1	0.35448609
77	HCK	0.35065145
78	MAP3K6	0.34841461
79	BRAF	0.34027908
80	PDGFRA	0.33978048
81	SRC	0.33855812
82	MAP3K9	0.33725049
83	RPS6KA1	0.32470566
84	KIT	0.30784269
85	PDK1	0.29991210
86	CAMK4	0.29917101
87	STK4	0.29028208
88	CAMK1G	0.28938798
89	VRK2	0.28885264
90	PRKCA	0.27694474
91	FYN	0.27117064
92	JAK2	0.26732363
93	PRKCG	0.26266236
94	MARK3	0.24389520
95	CSNK2A1	0.23643211
96	MAPK12	0.23221592
97	PTK6	0.22838504
98	MOS	0.22519167
99	TNK2	0.21900699
100	DAPK3	0.21256823

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Mineral absorption_Homo sapiens_hsa04978	4.96080891
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.58352201
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.80176218
4	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.69196244
5	Rheumatoid arthritis_Homo sapiens_hsa05323	2.61294928
6	Other glycan degradation_Homo sapiens_hsa00511	2.57239466
7	Lysosome_Homo sapiens_hsa04142	2.37050733
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.32723455
9	Complement and coagulation cascades_Homo sapiens_hsa04610	1.90526316
10	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.87003908
11	Pertussis_Homo sapiens_hsa05133	1.84552827
12	Galactose metabolism_Homo sapiens_hsa00052	1.79828129
13	Caffeine metabolism_Homo sapiens_hsa00232	1.75966424
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.74296486
15	Legionellosis_Homo sapiens_hsa05134	1.68579769
16	Renin-angiotensin system_Homo sapiens_hsa04614	1.62589408
17	Osteoclast differentiation_Homo sapiens_hsa04380	1.61214244
18	PPAR signaling pathway_Homo sapiens_hsa03320	1.60323366
19	Histidine metabolism_Homo sapiens_hsa00340	1.59927551
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.57534494
21	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.54990719
22	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.52555084
23	Sulfur metabolism_Homo sapiens_hsa00920	1.51048368
24	Phagosome_Homo sapiens_hsa04145	1.49349619
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.48928944
26	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.48047910
27	Tuberculosis_Homo sapiens_hsa05152	1.47256577
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.42615270
29	TNF signaling pathway_Homo sapiens_hsa04668	1.41005805
30	Folate biosynthesis_Homo sapiens_hsa00790	1.39959532
31	Prion diseases_Homo sapiens_hsa05020	1.39571405
32	Salmonella infection_Homo sapiens_hsa05132	1.34201655
33	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.33743095
34	Leishmaniasis_Homo sapiens_hsa05140	1.31492612
35	Malaria_Homo sapiens_hsa05144	1.29464958
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.28910477
37	Arginine biosynthesis_Homo sapiens_hsa00220	1.28066230
38	Retinol metabolism_Homo sapiens_hsa00830	1.27048285
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25614631
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.21655803
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.21195375
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.19249638
43	Pentose phosphate pathway_Homo sapiens_hsa00030	1.18968998
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.18576694
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13597100
46	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.13258857
47	Bladder cancer_Homo sapiens_hsa05219	1.09400797
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.05904694
49	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.05041129
50	Asthma_Homo sapiens_hsa05310	1.04498711
51	Chemokine signaling pathway_Homo sapiens_hsa04062	1.01746439
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00947294
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98914773
54	Glutathione metabolism_Homo sapiens_hsa00480	0.97742722
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94894694
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.93553318
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92890542
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.90921968
59	Fatty acid degradation_Homo sapiens_hsa00071	0.90700047
60	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.89792529
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87972098
62	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.86374789
63	Carbon metabolism_Homo sapiens_hsa01200	0.81240288
64	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76951711
65	Vibrio cholerae infection_Homo sapiens_hsa05110	0.75979994
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75017988
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73645353
68	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.73315264
69	Amoebiasis_Homo sapiens_hsa05146	0.72542816
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.71819290
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70266082
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.69723603
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.66216057
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64697599
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.61119286
76	Allograft rejection_Homo sapiens_hsa05330	0.60843667
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60406407
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57212785
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56754449
80	Bile secretion_Homo sapiens_hsa04976	0.56740405
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55895099
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.52885118
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52557995
84	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.46840976
85	Antigen processing and presentation_Homo sapiens_hsa04612	0.45955443
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45786253
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42566163
88	Shigellosis_Homo sapiens_hsa05131	0.40390734
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.39949102
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.38495263
91	Oxidative phosphorylation_Homo sapiens_hsa00190	0.37628382
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36650144
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.36134826
94	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.35461051
95	Influenza A_Homo sapiens_hsa05164	0.34361136
96	Hepatitis C_Homo sapiens_hsa05160	0.32902616
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32362573
98	African trypanosomiasis_Homo sapiens_hsa05143	0.31814635
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.31051827
100	Toxoplasmosis_Homo sapiens_hsa05145	0.29735163

MT1H

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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