ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to zinc ion (GO:0010043)	5.85898187
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.62962372
3	L-phenylalanine catabolic process (GO:0006559)	5.62962372
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.48501190
5	L-phenylalanine metabolic process (GO:0006558)	5.48501190
6	response to cadmium ion (GO:0046686)	4.52410318
7	glucosamine-containing compound catabolic process (GO:1901072)	4.47657582
8	xenobiotic catabolic process (GO:0042178)	3.96539357
9	aromatic amino acid family catabolic process (GO:0009074)	3.62111086
10	cellular zinc ion homeostasis (GO:0006882)	3.59698449
11	regulation of mononuclear cell migration (GO:0071675)	3.58557214
12	eosinophil chemotaxis (GO:0048245)	3.45556790
13	regulation of sequestering of triglyceride (GO:0010889)	3.32413572
14	production of molecular mediator involved in inflammatory response (GO:0002532)	3.31998923
15	amino sugar catabolic process (GO:0046348)	3.29842016
16	negative regulation of execution phase of apoptosis (GO:1900118)	3.24270077
17	low-density lipoprotein particle clearance (GO:0034383)	3.23219413
18	lipid storage (GO:0019915)	3.18761847
19	response to nitrosative stress (GO:0051409)	3.10955655
20	eosinophil migration (GO:0072677)	3.00670061
21	regulation of triglyceride catabolic process (GO:0010896)	3.00041572
22	response to hydroperoxide (GO:0033194)	2.94342454
23	acute-phase response (GO:0006953)	2.90619555
24	arginine catabolic process (GO:0006527)	2.88295185
25	cellular response to arsenic-containing substance (GO:0071243)	2.86758132
26	positive regulation of lipid storage (GO:0010884)	2.84856427
27	positive regulation of triglyceride metabolic process (GO:0090208)	2.77201294
28	zinc ion homeostasis (GO:0055069)	2.68875764
29	regulation of phospholipase A2 activity (GO:0032429)	2.67944898
30	response to transition metal nanoparticle (GO:1990267)	2.67393214
31	triglyceride catabolic process (GO:0019433)	2.61369677
32	negative regulation of complement activation (GO:0045916)	2.59844303
33	cellular response to metal ion (GO:0071248)	2.58217140
34	lipid particle organization (GO:0034389)	2.56963109
35	positive regulation of chemokine secretion (GO:0090197)	2.56394252
36	cellular ketone body metabolic process (GO:0046950)	2.54243580
37	zinc ion transport (GO:0006829)	2.53862456
38	digestion (GO:0007586)	2.50900588
39	negative regulation of protein activation cascade (GO:2000258)	2.49570652
40	alanine transport (GO:0032328)	2.47106133
41	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.44578452
42	aromatic amino acid family metabolic process (GO:0009072)	2.42685833
43	cell wall macromolecule metabolic process (GO:0044036)	2.42110456
44	negative regulation of membrane potential (GO:0045837)	2.41904714
45	regulation of vitamin D biosynthetic process (GO:0060556)	2.40850434
46	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.40671308
47	complement activation, alternative pathway (GO:0006957)	2.40395114
48	fatty acid homeostasis (GO:0055089)	2.40339087
49	negative regulation of viral entry into host cell (GO:0046597)	2.39783022
50	zinc ion transmembrane transport (GO:0071577)	2.39421845
51	C4-dicarboxylate transport (GO:0015740)	2.38453730
52	regulation of integrin-mediated signaling pathway (GO:2001044)	2.38407708
53	acylglycerol catabolic process (GO:0046464)	2.37576384
54	neutral lipid catabolic process (GO:0046461)	2.37576384
55	triglyceride homeostasis (GO:0070328)	2.36525088
56	acylglycerol homeostasis (GO:0055090)	2.36525088
57	lymphocyte chemotaxis (GO:0048247)	2.35994388
58	tyrosine metabolic process (GO:0006570)	2.35908469
59	negative regulation of lipid catabolic process (GO:0050995)	2.35897289
60	pyrimidine-containing compound salvage (GO:0008655)	2.34958769
61	pyrimidine nucleoside salvage (GO:0043097)	2.34958769
62	fibrinolysis (GO:0042730)	2.29814482
63	lipopolysaccharide biosynthetic process (GO:0009103)	2.28864889
64	fat-soluble vitamin biosynthetic process (GO:0042362)	2.28772309
65	regulation of transmission of nerve impulse (GO:0051969)	2.28260051
66	macrophage chemotaxis (GO:0048246)	2.27840455
67	opsonization (GO:0008228)	2.27167136
68	regulation of metalloenzyme activity (GO:0048552)	2.26473605
69	acute inflammatory response (GO:0002526)	2.26131812
70	regulation of macrophage chemotaxis (GO:0010758)	2.25509048
71	signal peptide processing (GO:0006465)	2.24569061
72	response to dietary excess (GO:0002021)	2.23256599
73	DNA deamination (GO:0045006)	2.20557835
74	regulation of chemokine secretion (GO:0090196)	2.20487262
75	cellular response to inorganic substance (GO:0071241)	2.20112976
76	negative regulation of lipase activity (GO:0060192)	2.19586876
77	dicarboxylic acid biosynthetic process (GO:0043650)	2.18305123
78	mannosylation (GO:0097502)	2.17298995
79	iron ion import (GO:0097286)	2.17258609
80	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.15880512
81	virion attachment to host cell (GO:0019062)	2.15819930
82	adhesion of symbiont to host cell (GO:0044650)	2.15819930
83	regulation of triglyceride biosynthetic process (GO:0010866)	2.15814899
84	regulation of triglyceride metabolic process (GO:0090207)	2.14500378
85	negative regulation of protein autophosphorylation (GO:0031953)	2.14117213
86	biotin metabolic process (GO:0006768)	2.14050213
87	vitamin biosynthetic process (GO:0009110)	2.13984829
88	regulation of chemokine biosynthetic process (GO:0045073)	2.13427292
89	transcytosis (GO:0045056)	2.13303046
90	ketone body metabolic process (GO:1902224)	2.13247838
91	negative regulation of focal adhesion assembly (GO:0051895)	2.11592442
92	negative regulation of cell junction assembly (GO:1901889)	2.11592442
93	negative regulation of adherens junction organization (GO:1903392)	2.11592442
94	glycerolipid catabolic process (GO:0046503)	2.11308224
95	glutathione derivative metabolic process (GO:1901685)	2.11085805
96	glutathione derivative biosynthetic process (GO:1901687)	2.11085805
97	negative regulation of lipid storage (GO:0010888)	2.10879354
98	cofactor catabolic process (GO:0051187)	2.10161449
99	cellular response to zinc ion (GO:0071294)	16.4400810
100	cellular response to cadmium ion (GO:0071276)	10.7425624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.12046058
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.00195170
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.94777315
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.85916553
5	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.47799475
6	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.71701379
7	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.57833153
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.57099860
9	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.54223588
10	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.35604112
11	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.35388148
12	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.27237553
13	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.23435980
14	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	2.20275796
15	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.13408153
16	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.09155600
17	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.96688556
18	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.95346525
19	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.94642168
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.92755206
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.89239635
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.85160811
23	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.80678474
24	SOX2_20726797_ChIP-Seq_SW620_Human	1.78774004
25	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.69284608
26	CJUN_26792858_Chip-Seq_BT549_Human	1.67793238
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.62249835
28	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.57867951
29	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.54566807
30	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.53034119
31	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.50305987
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.50007692
33	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.44443541
34	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.44259022
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43148154
36	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.42368689
37	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.42195338
38	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.41734149
39	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.37866217
40	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.33643656
41	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33349711
42	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.31912397
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.28694197
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27499018
45	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.26716046
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.25319560
47	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23503061
48	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.19383211
49	STAT1_20625510_ChIP-Seq_HELA_Human	1.16084319
50	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.15374613
51	CLOCK_20551151_ChIP-Seq_293T_Human	1.12709619
52	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.12581231
53	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.11920269
54	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.11920269
55	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.11398550
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09720746
57	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.09360432
58	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.08596756
59	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.05793113
60	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.04060405
61	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.03994573
62	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.03637115
63	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.00092988
64	CBP_21632823_ChIP-Seq_H3396_Human	0.99339543
65	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.97969265
66	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.97660053
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97187247
68	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.96712163
69	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.96340028
70	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.94175877
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94133653
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94133653
73	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.93267114
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91362005
75	ATF3_27146783_Chip-Seq_COLON_Human	0.88165340
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87977615
77	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.87673832
78	AR_20517297_ChIP-Seq_VCAP_Human	0.86942581
79	BCAT_22108803_ChIP-Seq_LS180_Human	0.86527632
80	MYC_19829295_ChIP-Seq_ESCs_Human	0.84353898
81	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.83393206
82	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.83013482
83	BCOR_27268052_Chip-Seq_Bcells_Human	0.82431045
84	GATA4_25053715_ChIP-Seq_YYC3_Human	0.80839373
85	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.80498871
86	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.80063582
87	CTCF_20526341_ChIP-Seq_ESCs_Human	0.79870646
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.77747898
89	TFEB_21752829_ChIP-Seq_HELA_Human	0.77536945
90	NCOR_22424771_ChIP-Seq_293T_Human	0.76024606
91	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.75143071
92	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.74586522
93	AHR_22903824_ChIP-Seq_MCF-7_Human	0.73625715
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.73573987
95	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.73287373
96	SA1_27219007_Chip-Seq_Bcells_Human	0.72958914
97	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.72640435
98	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.71975119
99	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.71837150
100	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.71620211

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.28731829
2	MP0003195_calcinosis	3.87669952
3	MP0003806_abnormal_nucleotide_metabolis	3.18200418
4	MP0009785_altered_susceptibility_to	3.02257652
5	MP0002139_abnormal_hepatobiliary_system	2.78966470
6	MP0000343_altered_response_to	2.73625297
7	MP0004510_myositis	2.65345854
8	MP0009840_abnormal_foam_cell	2.44544370
9	MP0005670_abnormal_white_adipose	2.36350938
10	MP0003950_abnormal_plasma_membrane	2.35371227
11	MP0001853_heart_inflammation	2.30529190
12	MP0005058_abnormal_lysosome_morphology	2.24101926
13	MP0002148_abnormal_hypersensitivity_rea	2.08513619
14	MP0005332_abnormal_amino_acid	2.05978116
15	MP0008875_abnormal_xenobiotic_pharmacok	2.04005173
16	MP0003011_delayed_dark_adaptation	2.01633235
17	MP0005365_abnormal_bile_salt	1.99046748
18	MP0003075_altered_response_to	1.95554013
19	MP0005167_abnormal_blood-brain_barrier	1.91835031
20	MP0006082_CNS_inflammation	1.88787552
21	MP0002971_abnormal_brown_adipose	1.88145566
22	MP0009764_decreased_sensitivity_to	1.86330019
23	MP0003186_abnormal_redox_activity	1.75499833
24	MP0002909_abnormal_adrenal_gland	1.60297083
25	MP0001764_abnormal_homeostasis	1.59936863
26	MP0005023_abnormal_wound_healing	1.56127191
27	MP0005666_abnormal_adipose_tissue	1.52388739
28	MP0003436_decreased_susceptibility_to	1.51022949
29	MP0002254_reproductive_system_inflammat	1.49593413
30	MP0005164_abnormal_response_to	1.47390731
31	MP0010329_abnormal_lipoprotein_level	1.44012296
32	MP0000604_amyloidosis	1.42826441
33	MP0006036_abnormal_mitochondrial_physio	1.38025200
34	MP0008469_abnormal_protein_level	1.36210693
35	MP0005360_urolithiasis	1.36183640
36	MP0005584_abnormal_enzyme/coenzyme_acti	1.33018162
37	MP0005166_decreased_susceptibility_to	1.30580396
38	MP0004019_abnormal_vitamin_homeostasis	1.30357690
39	MP0001533_abnormal_skeleton_physiology	1.28461421
40	MP0003045_fibrosis	1.27106090
41	MP0006072_abnormal_retinal_apoptosis	1.26058437
42	MP0005595_abnormal_vascular_smooth	1.25788637
43	MP0005387_immune_system_phenotype	1.24359716
44	MP0001790_abnormal_immune_system	1.24359716
45	MP0008004_abnormal_stomach_pH	1.23956138
46	MP0001845_abnormal_inflammatory_respons	1.23242154
47	MP0002295_abnormal_pulmonary_circulatio	1.23143984
48	MP0010368_abnormal_lymphatic_system	1.21747025
49	MP0005535_abnormal_body_temperature	1.19915523
50	MP0002419_abnormal_innate_immunity	1.17769449
51	MP0001501_abnormal_sleep_pattern	1.16723366
52	MP0005334_abnormal_fat_pad	1.15012179
53	MP0002118_abnormal_lipid_homeostasis	1.14815362
54	MP0005000_abnormal_immune_tolerance	1.13848868
55	MP0005448_abnormal_energy_balance	1.13374928
56	MP0002693_abnormal_pancreas_physiology	1.13045986
57	MP0003633_abnormal_nervous_system	1.12358628
58	MP0003191_abnormal_cellular_cholesterol	1.12138965
59	MP0002970_abnormal_white_adipose	1.11248547
60	MP0005379_endocrine/exocrine_gland_phen	1.09877210
61	MP0005375_adipose_tissue_phenotype	1.08985270
62	MP0002998_abnormal_bone_remodeling	1.07670222
63	MP0009333_abnormal_splenocyte_physiolog	1.07642839
64	MP0001542_abnormal_bone_strength	1.07436042
65	MP0009643_abnormal_urine_homeostasis	1.07054176
66	MP0005410_abnormal_fertilization	1.06536603
67	MP0009763_increased_sensitivity_to	1.06345576
68	MP0005025_abnormal_response_to	1.05259838
69	MP0004883_abnormal_blood_vessel	1.05071614
70	MP0009046_muscle_twitch	1.04236352
71	MP0004947_skin_inflammation	1.04036624
72	MP0002168_other_aberrant_phenotype	1.03837329
73	MP0005319_abnormal_enzyme/_coenzyme	1.01546330
74	MP0003453_abnormal_keratinocyte_physiol	1.01003848
75	MP0010234_abnormal_vibrissa_follicle	1.00576683
76	MP0002078_abnormal_glucose_homeostasis	0.99929025
77	MP0000609_abnormal_liver_physiology	0.97871736
78	MP0000427_abnormal_hair_cycle	0.97861382
79	MP0003724_increased_susceptibility_to	0.97376351
80	MP0005165_increased_susceptibility_to	0.95823651
81	MP0010307_abnormal_tumor_latency	0.95614091
82	MP0005636_abnormal_mineral_homeostasis	0.95137289
83	MP0008775_abnormal_heart_ventricle	0.91882373
84	MP0005376_homeostasis/metabolism_phenot	0.91521590
85	MP0000685_abnormal_immune_system	0.90633383
86	MP0003303_peritoneal_inflammation	0.90465870
87	MP0005397_hematopoietic_system_phenotyp	0.89528553
88	MP0001545_abnormal_hematopoietic_system	0.89528553
89	MP0003448_altered_tumor_morphology	0.88794014
90	MP0010678_abnormal_skin_adnexa	0.88517359
91	MP0008438_abnormal_cutaneous_collagen	0.87846650
92	MP0003279_aneurysm	0.86604075
93	MP0009278_abnormal_bone_marrow	0.84250782
94	MP0001756_abnormal_urination	0.82082790
95	MP0005671_abnormal_response_to	0.80725391
96	MP0001944_abnormal_pancreas_morphology	0.79436701
97	MP0002138_abnormal_hepatobiliary_system	0.79149827
98	MP0001881_abnormal_mammary_gland	0.78788920
99	MP0003329_amyloid_beta_deposits	0.78362746
100	MP0009765_abnormal_xenobiotic_induced	0.77010684

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.14924708
2	Abnormality of glycolipid metabolism (HP:0010969)	4.17132525
3	Abnormality of liposaccharide metabolism (HP:0010968)	4.17132525
4	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.17132525
5	Systemic lupus erythematosus (HP:0002725)	3.71055894
6	Complement deficiency (HP:0004431)	3.36445590
7	Xanthomatosis (HP:0000991)	3.21828410
8	Vacuolated lymphocytes (HP:0001922)	3.06719579
9	Progressive neurologic deterioration (HP:0002344)	3.03912120
10	Renal Fanconi syndrome (HP:0001994)	3.03652253
11	Insulin-resistant diabetes mellitus (HP:0000831)	2.98263768
12	Hypokinesia (HP:0002375)	2.87281844
13	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.81257025
14	Opisthotonus (HP:0002179)	2.79443136
15	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.72900098
16	Abnormal protein N-linked glycosylation (HP:0012347)	2.72900098
17	Abnormal protein glycosylation (HP:0012346)	2.72900098
18	Abnormal glycosylation (HP:0012345)	2.72900098
19	Abnormality of complement system (HP:0005339)	2.69906416
20	Dysostosis multiplex (HP:0000943)	2.64409020
21	Hepatic necrosis (HP:0002605)	2.64383290
22	3-Methylglutaconic aciduria (HP:0003535)	2.59668289
23	Hepatocellular necrosis (HP:0001404)	2.56868199
24	Acute hepatic failure (HP:0006554)	2.51066465
25	Axonal loss (HP:0003447)	2.49276433
26	Ketoacidosis (HP:0001993)	2.47933578
27	Vascular calcification (HP:0004934)	2.46512054
28	Bone cyst (HP:0012062)	2.45256011
29	Recurrent gram-negative bacterial infections (HP:0005420)	2.43717811
30	Symptomatic seizures (HP:0011145)	2.40394661
31	Hypertriglyceridemia (HP:0002155)	2.39507988
32	Mitochondrial inheritance (HP:0001427)	2.38283504
33	Epidermoid cyst (HP:0200040)	2.37295672
34	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.36985192
35	Abnormality of polysaccharide metabolism (HP:0011012)	2.36985192
36	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.36985192
37	Generalized aminoaciduria (HP:0002909)	2.36029463
38	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.32425776
39	Glomerulonephritis (HP:0000099)	2.31488164
40	Hyperglycemia (HP:0003074)	2.30560589
41	Hematochezia (HP:0002573)	2.29060261
42	Hyperinsulinemic hypoglycemia (HP:0000825)	2.28584073
43	Insulin resistance (HP:0000855)	2.26246502
44	Ketosis (HP:0001946)	2.26234866
45	Horizontal nystagmus (HP:0000666)	2.23609057
46	Increased muscle lipid content (HP:0009058)	2.22532177
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22040365
48	Cardiovascular calcification (HP:0011915)	2.21664006
49	Increased CSF protein (HP:0002922)	2.20427701
50	Episodic fever (HP:0001954)	2.18226778
51	Urinary glycosaminoglycan excretion (HP:0003541)	2.16488045
52	Mucopolysacchariduria (HP:0008155)	2.16488045
53	Abnormality of renal resorption (HP:0011038)	2.12637873
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.12371719
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.12371719
56	Abnormality of macrophages (HP:0004311)	2.11345011
57	Hyperlipoproteinemia (HP:0010980)	2.10668713
58	Myocardial infarction (HP:0001658)	2.08911192
59	Craniofacial dystonia (HP:0012179)	2.08236447
60	Focal dystonia (HP:0004373)	2.08187426
61	Pancreatic islet-cell hyperplasia (HP:0004510)	2.07854749
62	Torticollis (HP:0000473)	2.07038917
63	Acute necrotizing encephalopathy (HP:0006965)	2.06396168
64	Hyperammonemia (HP:0001987)	2.05968853
65	Acanthosis nigricans (HP:0000956)	2.04929921
66	Hypoglycemic seizures (HP:0002173)	2.04081851
67	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02894191
68	Dicarboxylic aciduria (HP:0003215)	1.99633954
69	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.99633954
70	Abnormality of the basal ganglia (HP:0002134)	1.98128772
71	Petechiae (HP:0000967)	1.97252670
72	Abnormality of alanine metabolism (HP:0010916)	1.96627523
73	Hyperalaninemia (HP:0003348)	1.96627523
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96627523
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.96217718
76	Prolonged neonatal jaundice (HP:0006579)	1.94222415
77	Severe visual impairment (HP:0001141)	1.94122516
78	Glucose intolerance (HP:0000833)	1.91670674
79	Conjugated hyperbilirubinemia (HP:0002908)	1.91548244
80	Progressive macrocephaly (HP:0004481)	1.91134519
81	Type I transferrin isoform profile (HP:0003642)	1.90028834
82	Hypoglycemic coma (HP:0001325)	1.89671597
83	Pendular nystagmus (HP:0012043)	1.89403953
84	Prolonged partial thromboplastin time (HP:0003645)	1.89201059
85	Glycosuria (HP:0003076)	1.88574223
86	Abnormality of urine glucose concentration (HP:0011016)	1.88574223
87	Abnormality of pyrimidine metabolism (HP:0004353)	1.85153234
88	Increased CSF lactate (HP:0002490)	1.83748828
89	Hemiparesis (HP:0001269)	1.83642768
90	Lipid accumulation in hepatocytes (HP:0006561)	1.83506607
91	CNS demyelination (HP:0007305)	1.82258147
92	Abnormality of the pancreatic islet cells (HP:0006476)	1.81564444
93	Abnormality of endocrine pancreas physiology (HP:0012093)	1.81564444
94	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.81492739
95	Joint hemorrhage (HP:0005261)	1.81190584
96	Abnormality of the periventricular white matter (HP:0002518)	1.79713367
97	Ileus (HP:0002595)	1.79043470
98	Congenital sensorineural hearing impairment (HP:0008527)	1.78650053
99	Abnormal glucose tolerance (HP:0001952)	1.77892761
100	Malnutrition (HP:0004395)	1.75984786

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	4.51822624
2	MUSK	4.49957120
3	MAP3K3	3.03381654
4	FRK	2.51193436
5	IRAK3	2.41965565
6	MAP4K2	2.16647582
7	PDK2	2.10237383
8	MAP3K13	2.08722176
9	TESK1	2.06100300
10	MYLK	1.93255531
11	ERBB4	1.92579748
12	NME2	1.91981636
13	KDR	1.84543147
14	MST4	1.84081435
15	LIMK1	1.78493397
16	MAP3K11	1.66384270
17	ADRBK2	1.60712759
18	GRK7	1.59667598
19	TAOK2	1.57338529
20	ERN1	1.56755416
21	BLK	1.53157296
22	ABL2	1.51032462
23	IKBKB	1.48686694
24	TGFBR2	1.46379829
25	TESK2	1.38817661
26	EIF2AK3	1.36054745
27	FER	1.34998603
28	MAP3K9	1.31444268
29	GSK3A	1.30342266
30	ARAF	1.23696183
31	TRPM7	1.23246922
32	GRK1	1.20469414
33	DDR2	1.18103301
34	MOS	1.15727122
35	MAP3K1	1.14839685
36	PHKG2	1.14101204
37	PHKG1	1.14101204
38	LMTK2	1.13821377
39	PAK4	1.12697068
40	ZAK	1.11598177
41	EPHA3	1.10459220
42	PRKG2	1.07877810
43	EPHB1	1.06966417
44	IRAK1	1.04851699
45	MARK3	1.02127494
46	BCKDK	1.00756365
47	MAP3K14	1.00049060
48	CLK1	0.99932523
49	MAPKAPK3	0.98226727
50	STK16	0.96551761
51	PINK1	0.96239816
52	DAPK2	0.91654076
53	MAP3K5	0.88871087
54	PIM2	0.88806610
55	JAK1	0.86165878
56	TAOK1	0.86130258
57	ZAP70	0.86088795
58	ADRBK1	0.85810585
59	CSK	0.85496465
60	PRKAA2	0.83458172
61	PKN1	0.80935663
62	TBK1	0.78691411
63	MAP3K2	0.77651058
64	CAMK2G	0.76931538
65	AKT3	0.69710547
66	IKBKE	0.64980359
67	CHUK	0.64133384
68	CAMK2D	0.63927194
69	EPHA2	0.62608232
70	DAPK1	0.61975192
71	MST1R	0.60851443
72	PTK2	0.60245978
73	SCYL2	0.59891936
74	BUB1	0.57934510
75	TYK2	0.56403544
76	CAMKK2	0.55978324
77	PDK1	0.55229657
78	TLK1	0.54252315
79	PAK3	0.51058253
80	ABL1	0.49972716
81	BMPR2	0.47995978
82	PAK1	0.47243608
83	HIPK2	0.44197396
84	FLT3	0.44134092
85	MAP4K1	0.43214957
86	ROCK1	0.42514833
87	PRKCE	0.40892404
88	IGF1R	0.39777923
89	EPHB2	0.39716046
90	JAK2	0.39014813
91	PRKCI	0.38809867
92	DAPK3	0.38034164
93	PRKACG	0.37590502
94	MAPK7	0.36501728
95	CSF1R	0.35457003
96	AKT2	0.33472649
97	PTK2B	0.32737903
98	CAMK2A	0.32206043
99	INSR	0.32102533
100	PRKCG	0.30703175

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mineral absorption_Homo sapiens_hsa04978	5.44073277
2	Fatty acid elongation_Homo sapiens_hsa00062	2.60487179
3	Folate biosynthesis_Homo sapiens_hsa00790	2.42079383
4	Complement and coagulation cascades_Homo sapiens_hsa04610	2.29275436
5	Other glycan degradation_Homo sapiens_hsa00511	2.05973096
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.01600681
7	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99399226
8	Collecting duct acid secretion_Homo sapiens_hsa04966	1.97616610
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.93081882
10	PPAR signaling pathway_Homo sapiens_hsa03320	1.84657302
11	Butanoate metabolism_Homo sapiens_hsa00650	1.76637138
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.75707692
13	Sulfur metabolism_Homo sapiens_hsa00920	1.69914568
14	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.68614105
15	Proteasome_Homo sapiens_hsa03050	1.67998400
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.63549112
17	Pertussis_Homo sapiens_hsa05133	1.61711036
18	Glutathione metabolism_Homo sapiens_hsa00480	1.59617761
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57933589
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.52489737
21	Fatty acid degradation_Homo sapiens_hsa00071	1.47349937
22	Lysosome_Homo sapiens_hsa04142	1.46333328
23	Tyrosine metabolism_Homo sapiens_hsa00350	1.43823019
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.40054645
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.38066168
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.32777976
27	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.32120073
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29536231
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.27646364
30	Phenylalanine metabolism_Homo sapiens_hsa00360	1.27550635
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24135246
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.23555228
33	Parkinsons disease_Homo sapiens_hsa05012	1.22746249
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21560316
35	Protein export_Homo sapiens_hsa03060	1.21188991
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.19033197
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.15544355
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.13511182
39	Caffeine metabolism_Homo sapiens_hsa00232	1.13211680
40	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.12259619
41	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.10040365
42	TNF signaling pathway_Homo sapiens_hsa04668	1.09305713
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08766324
44	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.07643882
45	Prion diseases_Homo sapiens_hsa05020	1.06618918
46	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.04325572
47	Legionellosis_Homo sapiens_hsa05134	1.03860358
48	Fat digestion and absorption_Homo sapiens_hsa04975	1.03341458
49	Alzheimers disease_Homo sapiens_hsa05010	0.98555869
50	Peroxisome_Homo sapiens_hsa04146	0.98433349
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98220328
52	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.98191406
53	Malaria_Homo sapiens_hsa05144	0.96311815
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.96197159
55	Retinol metabolism_Homo sapiens_hsa00830	0.94298597
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92580022
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.89854135
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.88634348
59	Galactose metabolism_Homo sapiens_hsa00052	0.86632401
60	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.86133711
61	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.86085491
62	Propanoate metabolism_Homo sapiens_hsa00640	0.83598763
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.80592313
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80570137
65	Vibrio cholerae infection_Homo sapiens_hsa05110	0.73753041
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73680833
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72850753
68	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.71926038
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.70961329
70	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.69953323
71	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.69749889
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.69022695
73	Salmonella infection_Homo sapiens_hsa05132	0.68129918
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62982119
75	Sulfur relay system_Homo sapiens_hsa04122	0.62469232
76	Carbon metabolism_Homo sapiens_hsa01200	0.60927553
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60255807
78	African trypanosomiasis_Homo sapiens_hsa05143	0.60189508
79	Shigellosis_Homo sapiens_hsa05131	0.58954698
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.57843701
81	Huntingtons disease_Homo sapiens_hsa05016	0.56924859
82	Metabolic pathways_Homo sapiens_hsa01100	0.56633293
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56608036
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56262665
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55361497
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55224103
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54721272
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53290633
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.51882991
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51462075
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49470298
92	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49357301
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.44461227
94	Osteoclast differentiation_Homo sapiens_hsa04380	0.40876835
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40672012
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39476662
97	Bile secretion_Homo sapiens_hsa04976	0.38910458
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38687016
99	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.37753694
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37633912

MT1JP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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