MT1M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to cadmium ion (GO:0046686)5.30580842
2* response to zinc ion (GO:0010043)4.65513876
3regulation of mononuclear cell migration (GO:0071675)4.35428554
4regulation of macrophage chemotaxis (GO:0010758)4.31910575
5fat-soluble vitamin biosynthetic process (GO:0042362)4.27696218
6positive regulation of lipoprotein lipase activity (GO:0051006)4.15514276
7positive regulation of triglyceride lipase activity (GO:0061365)4.15514276
8complement activation, alternative pathway (GO:0006957)3.97034546
9epoxygenase P450 pathway (GO:0019373)3.65636259
10barbed-end actin filament capping (GO:0051016)3.49553808
11positive regulation of fatty acid biosynthetic process (GO:0045723)3.29511766
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26693481
13cellular response to thyroid hormone stimulus (GO:0097067)3.26331124
14apoptotic cell clearance (GO:0043277)3.25613203
15eosinophil chemotaxis (GO:0048245)3.25338107
16acute-phase response (GO:0006953)3.21495458
17omega-hydroxylase P450 pathway (GO:0097267)3.17235450
18virion attachment to host cell (GO:0019062)3.14057302
19adhesion of symbiont to host cell (GO:0044650)3.14057302
20regulation of triglyceride catabolic process (GO:0010896)3.11720973
21angiotensin maturation (GO:0002003)3.04659034
22regulation of vitamin metabolic process (GO:0030656)2.98068733
23low-density lipoprotein particle clearance (GO:0034383)2.97820669
24regulation of vitamin D biosynthetic process (GO:0060556)2.96304961
25ethanol oxidation (GO:0006069)2.96005546
26adhesion of symbiont to host (GO:0044406)2.87657700
27eosinophil migration (GO:0072677)2.82600521
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82562155
29L-phenylalanine metabolic process (GO:0006558)2.82562155
30positive regulation of triglyceride metabolic process (GO:0090208)2.78977857
31negative regulation of myeloid cell apoptotic process (GO:0033033)2.73267430
32plasma lipoprotein particle clearance (GO:0034381)2.68996995
33regulation of cholesterol esterification (GO:0010872)2.68888115
34response to thyroid hormone (GO:0097066)2.63652183
35response to peptidoglycan (GO:0032494)2.63630474
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61404775
37L-phenylalanine catabolic process (GO:0006559)2.61404775
38negative regulation of interleukin-12 production (GO:0032695)2.60338136
39regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58867956
40vitamin A metabolic process (GO:0006776)2.57517182
41lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54871225
42macromolecular complex remodeling (GO:0034367)2.54184673
43plasma lipoprotein particle remodeling (GO:0034369)2.54184673
44protein-lipid complex remodeling (GO:0034368)2.54184673
45fibrinolysis (GO:0042730)2.54174708
46phospholipid efflux (GO:0033700)2.53888078
47glycosphingolipid catabolic process (GO:0046479)2.53847391
48fructose metabolic process (GO:0006000)2.52913639
49positive regulation of lipid catabolic process (GO:0050996)2.52271558
50response to copper ion (GO:0046688)2.51708419
51monocyte chemotaxis (GO:0002548)2.49457223
52positive regulation of cholesterol efflux (GO:0010875)2.49316344
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47202645
54negative regulation of fibrinolysis (GO:0051918)2.46185088
55complement activation (GO:0006956)2.45695093
56* cellular response to metal ion (GO:0071248)2.41733259
57regulation of cholesterol homeostasis (GO:2000188)2.39518899
58negative regulation of coagulation (GO:0050819)2.39064439
59negative regulation of hemostasis (GO:1900047)2.37561149
60negative regulation of blood coagulation (GO:0030195)2.37561149
61acylglycerol homeostasis (GO:0055090)2.36784174
62triglyceride homeostasis (GO:0070328)2.36784174
63monocyte differentiation (GO:0030224)2.36446792
64negative regulation of cholesterol transport (GO:0032375)2.36355623
65negative regulation of sterol transport (GO:0032372)2.36355623
66positive regulation of cellular amide metabolic process (GO:0034250)2.36226993
67aromatic amino acid family catabolic process (GO:0009074)2.35694331
68lymphocyte chemotaxis (GO:0048247)2.35025973
69* response to transition metal nanoparticle (GO:1990267)2.34656794
70regulation of fibrinolysis (GO:0051917)2.34165392
71hydrogen peroxide biosynthetic process (GO:0050665)2.33721776
72glycolipid catabolic process (GO:0019377)2.33057536
73regulation of protein activation cascade (GO:2000257)2.32378242
74lipid storage (GO:0019915)2.32342996
75regulation of complement activation (GO:0030449)2.29974289
76acute inflammatory response (GO:0002526)2.29613559
77NADH metabolic process (GO:0006734)2.28807087
78regulation of cholesterol storage (GO:0010885)2.28291473
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28206908
80negative regulation of lipid storage (GO:0010888)2.27487518
81regulation of apoptotic cell clearance (GO:2000425)2.25934768
82regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.24780003
83regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24683532
84low-density lipoprotein particle remodeling (GO:0034374)2.24619551
85peptide catabolic process (GO:0043171)2.24027486
86glial cell migration (GO:0008347)2.23328811
87cholesterol efflux (GO:0033344)2.22334737
88cellular response to leptin stimulus (GO:0044320)2.20509755
89L-amino acid import (GO:0043092)2.20080648
90oxaloacetate metabolic process (GO:0006107)2.19165358
91complement activation, classical pathway (GO:0006958)2.19001604
92diacylglycerol metabolic process (GO:0046339)2.18948817
93response to magnesium ion (GO:0032026)2.18427261
94triglyceride catabolic process (GO:0019433)2.17508639
95exogenous drug catabolic process (GO:0042738)2.17426658
96protein activation cascade (GO:0072376)2.17307108
97response to leptin (GO:0044321)2.17183977
98positive regulation of cholesterol transport (GO:0032376)2.16879836
99* cellular response to zinc ion (GO:0071294)13.8779174
100cellular response to cadmium ion (GO:0071276)12.6657373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.20758699
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.13618995
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.06971703
4* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.31521385
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72182356
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.64268036
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61668521
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.53180788
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49297949
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29373456
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.19997150
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.18857847
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.17386780
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.06432431
15LXR_22292898_ChIP-Seq_THP-1_Human2.06015932
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96921383
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89955690
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.87943801
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83937646
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81643775
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.73743476
22CLOCK_20551151_ChIP-Seq_293T_Human1.72327741
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66863652
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63823390
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.63050823
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62907525
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49728722
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49405433
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.48007602
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45624811
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42455988
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36213937
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.34448145
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32677664
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29156742
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26735907
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25351016
38VDR_24787735_ChIP-Seq_THP-1_Human1.24485225
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24309250
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23701930
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22908009
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22325457
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20610948
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.18688588
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17972763
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17867267
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17576532
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16253832
49SOX2_20726797_ChIP-Seq_SW620_Human1.16161593
50VDR_24763502_ChIP-Seq_THP-1_Human1.14329135
51EGR1_19032775_ChIP-ChIP_M12_Human1.14171931
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11316593
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10098929
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.10040881
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09033624
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08098283
57* ERG_21242973_ChIP-ChIP_JURKAT_Human1.07848380
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07451436
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05618626
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03923796
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03340597
62BCOR_27268052_Chip-Seq_Bcells_Human1.02489845
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02383583
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01990131
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01256226
66SPI1_23127762_ChIP-Seq_K562_Human1.00252984
67SA1_27219007_Chip-Seq_Bcells_Human1.00213339
68STAT1_20625510_ChIP-Seq_HELA_Human1.00168118
69KDM2B_26808549_Chip-Seq_K562_Human0.99842215
70TBX20_22080862_ChIP-Seq_HEART_Mouse0.97888020
71TBX20_22328084_ChIP-Seq_HEART_Mouse0.97888020
72SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97708664
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96606004
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96395406
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95977738
76RACK7_27058665_Chip-Seq_MCF-7_Human0.95912262
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95654826
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94285833
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94240149
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93036916
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92126074
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91460128
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89545850
84CDX2_20551321_ChIP-Seq_CACO-2_Human0.89131638
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88950430
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.88010715
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88003598
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87223841
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87072389
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86999136
91BCL6_27268052_Chip-Seq_Bcells_Human0.86468152
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84938984
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83850535
94CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83604820
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82607126
96NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82466821
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.81991670
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81717299
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81709500
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81564240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.25781323
2MP0003011_delayed_dark_adaptation4.12527873
3MP0002139_abnormal_hepatobiliary_system3.87522844
4MP0003191_abnormal_cellular_cholesterol2.88553572
5MP0000343_altered_response_to2.79065627
6MP0005167_abnormal_blood-brain_barrier2.75289693
7MP0009785_altered_susceptibility_to2.69844401
8MP0003075_altered_response_to2.56694706
9MP0005365_abnormal_bile_salt2.39516057
10MP0003436_decreased_susceptibility_to2.38376863
11MP0005360_urolithiasis2.35291155
12MP0005058_abnormal_lysosome_morphology2.24929496
13MP0004510_myositis2.21574221
14MP0003195_calcinosis2.19723604
15MP0003806_abnormal_nucleotide_metabolis2.18810361
16MP0002148_abnormal_hypersensitivity_rea2.17589000
17MP0003303_peritoneal_inflammation2.14218125
18MP0009764_decreased_sensitivity_to2.07410325
19MP0000604_amyloidosis2.03718980
20MP0002837_dystrophic_cardiac_calcinosis1.93470062
21MP0009278_abnormal_bone_marrow1.90466818
22MP0003690_abnormal_glial_cell1.85450892
23MP0004019_abnormal_vitamin_homeostasis1.83736108
24MP0006082_CNS_inflammation1.78828533
25MP0005166_decreased_susceptibility_to1.77853098
26MP0001853_heart_inflammation1.76441259
27MP0005670_abnormal_white_adipose1.74071906
28MP0002419_abnormal_innate_immunity1.70099207
29MP0001533_abnormal_skeleton_physiology1.67846812
30MP0003724_increased_susceptibility_to1.67058331
31MP0002998_abnormal_bone_remodeling1.66399967
32MP0008875_abnormal_xenobiotic_pharmacok1.66335522
33MP0003329_amyloid_beta_deposits1.57677096
34MP0010329_abnormal_lipoprotein_level1.55376812
35MP0005595_abnormal_vascular_smooth1.53290461
36MP0005025_abnormal_response_to1.43345146
37MP0010368_abnormal_lymphatic_system1.41505608
38MP0003828_pulmonary_edema1.40877717
39MP0002971_abnormal_brown_adipose1.40614469
40MP0005023_abnormal_wound_healing1.36266367
41MP0005000_abnormal_immune_tolerance1.36155074
42MP0000920_abnormal_myelination1.35351828
43MP0005085_abnormal_gallbladder_physiolo1.33252224
44MP0005451_abnormal_body_composition1.32576431
45MP0003300_gastrointestinal_ulcer1.31184647
46MP0005387_immune_system_phenotype1.29592176
47MP0001790_abnormal_immune_system1.29592176
48MP0003705_abnormal_hypodermis_morpholog1.29294499
49MP0003279_aneurysm1.28463868
50MP0001545_abnormal_hematopoietic_system1.27001548
51MP0005397_hematopoietic_system_phenotyp1.27001548
52MP0005164_abnormal_response_to1.26647475
53MP0003950_abnormal_plasma_membrane1.23532547
54MP0008004_abnormal_stomach_pH1.20913950
55MP0001845_abnormal_inflammatory_respons1.20164761
56MP0003448_altered_tumor_morphology1.18349083
57MP0008469_abnormal_protein_level1.17567679
58MP0008874_decreased_physiological_sensi1.14978058
59MP0003186_abnormal_redox_activity1.12271417
60MP0003879_abnormal_hair_cell1.12063982
61MP0002138_abnormal_hepatobiliary_system1.11907463
62MP0008260_abnormal_autophagy1.11298765
63MP0005535_abnormal_body_temperature1.10882944
64MP0002118_abnormal_lipid_homeostasis1.10077377
65MP0005332_abnormal_amino_acid1.04258051
66MP0002933_joint_inflammation1.03939125
67MP0000249_abnormal_blood_vessel1.03521053
68MP0001764_abnormal_homeostasis1.03272729
69MP0004883_abnormal_blood_vessel1.01607618
70MP0003172_abnormal_lysosome_physiology1.01568426
71MP0003453_abnormal_keratinocyte_physiol0.99638867
72MP0009763_increased_sensitivity_to0.99497874
73MP0005165_increased_susceptibility_to0.98370225
74MP0010155_abnormal_intestine_physiology0.96744385
75MP0003633_abnormal_nervous_system0.96494251
76MP0002295_abnormal_pulmonary_circulatio0.95164139
77MP0001501_abnormal_sleep_pattern0.94602309
78MP0005334_abnormal_fat_pad0.93007098
79MP0005666_abnormal_adipose_tissue0.92546477
80MP0005584_abnormal_enzyme/coenzyme_acti0.91738681
81MP0009115_abnormal_fat_cell0.91676066
82MP0008438_abnormal_cutaneous_collagen0.90116838
83MP0001666_abnormal_nutrient_absorption0.88688607
84MP0000609_abnormal_liver_physiology0.88608208
85MP0004947_skin_inflammation0.86836393
86MP0009765_abnormal_xenobiotic_induced0.86654953
87MP0000858_altered_metastatic_potential0.84765715
88MP0003868_abnormal_feces_composition0.84577015
89MP0002452_abnormal_antigen_presenting0.82625676
90MP0002896_abnormal_bone_mineralization0.81087632
91MP0005319_abnormal_enzyme/_coenzyme0.76087494
92MP0002723_abnormal_immune_serum0.74989211
93MP0000685_abnormal_immune_system0.74051623
94MP0001958_emphysema0.73402491
95MP0005448_abnormal_energy_balance0.73263001
96MP0001835_abnormal_antigen_presentation0.71195830
97MP0005390_skeleton_phenotype0.71079170
98MP0000750_abnormal_muscle_regeneration0.70713028
99MP0005423_abnormal_somatic_nervous0.69659542
100MP0003091_abnormal_cell_migration0.69560067

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.48211940
2Complement deficiency (HP:0004431)6.20294190
3Abnormality of complement system (HP:0005339)5.21304994
4Glomerulonephritis (HP:0000099)4.27883238
5Abnormality of liposaccharide metabolism (HP:0010968)4.23195354
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.23195354
7Abnormality of glycolipid metabolism (HP:0010969)4.23195354
8Recurrent gram-negative bacterial infections (HP:0005420)4.19845203
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10947196
10Xanthomatosis (HP:0000991)3.89183940
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81126493
12Neurofibrillary tangles (HP:0002185)3.61718851
13Axonal loss (HP:0003447)3.47066591
14Amyloidosis (HP:0011034)3.38128931
15Malnutrition (HP:0004395)3.21677275
16Deep venous thrombosis (HP:0002625)3.19862792
17Mutism (HP:0002300)3.02787264
18Eczematoid dermatitis (HP:0000976)2.97680171
19Abnormality of macrophages (HP:0004311)2.87959216
20Nephritis (HP:0000123)2.81469290
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79281075
22Retinal atrophy (HP:0001105)2.76892623
23Hypertriglyceridemia (HP:0002155)2.67776663
24Myocardial infarction (HP:0001658)2.66160989
25Cerebral inclusion bodies (HP:0100314)2.64607958
26Recurrent abscess formation (HP:0002722)2.62776844
27Dysostosis multiplex (HP:0000943)2.59861324
28Increased serum ferritin (HP:0003281)2.58117102
29Metaphyseal irregularity (HP:0003025)2.50410124
30Action tremor (HP:0002345)2.47000673
31Bone cyst (HP:0012062)2.44584795
32Hyperlipoproteinemia (HP:0010980)2.41745152
33Joint hemorrhage (HP:0005261)2.39664659
34Increased cerebral lipofuscin (HP:0011813)2.34287535
35Loss of speech (HP:0002371)2.30558788
36Recurrent bacterial skin infections (HP:0005406)2.29834002
37Purpura (HP:0000979)2.29048609
38Abnormality of proline metabolism (HP:0010907)2.26096947
39Hydroxyprolinuria (HP:0003080)2.26096947
40Hematochezia (HP:0002573)2.25324712
41Prolonged partial thromboplastin time (HP:0003645)2.20086455
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19543566
43Abnormality of polysaccharide metabolism (HP:0011012)2.19543566
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19543566
45Thin bony cortex (HP:0002753)2.18920838
46Spontaneous hematomas (HP:0007420)2.18048364
47Hypophosphatemia (HP:0002148)2.15953504
48Muscle fiber splitting (HP:0003555)2.11790830
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10917846
50Abnormality of the periventricular white matter (HP:0002518)2.10256281
51Bulbar palsy (HP:0001283)2.08592274
52Vacuolated lymphocytes (HP:0001922)2.08563933
53Myokymia (HP:0002411)2.06659946
54Nausea (HP:0002018)2.05753839
55Abnormality of iron homeostasis (HP:0011031)2.05504617
56Bone pain (HP:0002653)2.04571720
57Hemorrhage of the eye (HP:0011885)2.01780645
58Mucopolysacchariduria (HP:0008155)2.01220699
59Urinary glycosaminoglycan excretion (HP:0003541)2.01220699
60Vertebral compression fractures (HP:0002953)2.00556614
61Supranuclear gaze palsy (HP:0000605)2.00409219
62Increased neuronal autofluorescent lipopigment (HP:0002074)1.99246713
63Distal lower limb amyotrophy (HP:0008944)1.97668828
64Hypoalphalipoproteinemia (HP:0003233)1.97619766
65Distal lower limb muscle weakness (HP:0009053)1.96184742
66Symptomatic seizures (HP:0011145)1.95893095
67Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95416162
68Dementia (HP:0000726)1.95198248
69Nuclear cataract (HP:0100018)1.93817200
70Generalized aminoaciduria (HP:0002909)1.93478882
71Hyperparathyroidism (HP:0000843)1.93275478
72Protuberant abdomen (HP:0001538)1.92849601
73Conjunctival telangiectasia (HP:0000524)1.91015481
74Pathologic fracture (HP:0002756)1.90583930
75Segmental peripheral demyelination/remyelination (HP:0003481)1.90210743
76Widely patent fontanelles and sutures (HP:0004492)1.88935375
77Mediastinal lymphadenopathy (HP:0100721)1.88698231
78Skin nodule (HP:0200036)1.88535787
79Delayed epiphyseal ossification (HP:0002663)1.88483315
80Upper limb amyotrophy (HP:0009129)1.88172388
81Distal upper limb amyotrophy (HP:0007149)1.88172388
82Abnormality of the costochondral junction (HP:0000919)1.87989218
83Steatorrhea (HP:0002570)1.86858439
84Cerebral hemorrhage (HP:0001342)1.84023714
85Visceral angiomatosis (HP:0100761)1.80881022
86Hypobetalipoproteinemia (HP:0003563)1.80288474
87Neuronal loss in central nervous system (HP:0002529)1.79960333
88Insulin-resistant diabetes mellitus (HP:0000831)1.79448565
89Fat malabsorption (HP:0002630)1.78756322
90Orchitis (HP:0100796)1.77144506
91Intrahepatic cholestasis (HP:0001406)1.75577074
92Progressive visual loss (HP:0000529)1.73817576
93Abnormal eating behavior (HP:0100738)1.73567574
94Polycythemia (HP:0001901)1.73106413
95Acanthosis nigricans (HP:0000956)1.72126768
96Elevated alkaline phosphatase (HP:0003155)1.70716275
97Increased CSF protein (HP:0002922)1.69922510
98Gingivitis (HP:0000230)1.69821672
99Abnormality of the nasal mucosa (HP:0000433)1.68667395
100Congenital stationary night blindness (HP:0007642)1.67999426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.49590045
2NME23.23729534
3TGFBR23.09879949
4DDR23.08176798
5IRAK32.73340447
6TESK12.49297167
7RIPK12.43839465
8PRPF4B2.31616927
9RIPK42.06448267
10TAOK22.05260248
11ARAF2.04596550
12ABL21.97269191
13LATS21.87250514
14BLK1.79569283
15GRK71.75864074
16TYK21.71443964
17PDK21.66761353
18MAP3K131.64506867
19PINK11.62585663
20MAP3K111.60884200
21CSK1.57301307
22MAP3K31.56574692
23MOS1.56457442
24CAMKK21.55870365
25LIMK11.55280349
26GRK11.50508287
27PAK61.46657345
28DAPK21.45917230
29CDC42BPA1.41578411
30PRKG21.38822493
31MATK1.35322417
32ACVR1B1.35101280
33MAP3K11.29576992
34EPHB21.28704806
35TBK11.21733304
36MYLK1.18355029
37MAP3K121.10368755
38PDGFRA1.09081492
39FGR1.02943693
40JAK10.95764905
41MAPK120.93818997
42MAP3K140.93536361
43PDPK10.93154044
44CAMK2G0.88778912
45NTRK30.85591005
46EPHB10.85359709
47PIM20.83722230
48LMTK20.79473752
49PRKAA20.78906231
50KSR20.76648646
51CAMKK10.76100066
52ADRBK20.75766783
53MAPKAPK30.74810212
54TAOK10.73973761
55TYRO30.71814204
56ZAP700.70636178
57MAPK40.68621572
58EPHA40.67218298
59DMPK0.66608630
60JAK20.66382245
61EPHA30.65505123
62GRK50.65303143
63PAK40.65137366
64DAPK30.64089135
65CAMK2B0.63396030
66TTN0.63116563
67TESK20.62829004
68IKBKE0.60389674
69BMX0.58827382
70IKBKB0.58020027
71PDGFRB0.55693633
72CLK10.55491505
73PDK10.55461659
74CAMK2D0.55274657
75PRKACG0.54436369
76KDR0.52862959
77CSF1R0.52000348
78GSK3A0.50096324
79MAP2K30.47282215
80MAP3K90.46731180
81DAPK10.46255120
82JAK30.45955706
83PRKCG0.45742243
84SGK30.45436577
85MAP2K60.44724874
86TRIB30.43671202
87MAPK70.43443293
88SGK2230.42932664
89SGK4940.42932664
90CDK50.42857747
91ROCK10.42807052
92PRKCD0.42799094
93TGFBR10.42585838
94TIE10.42290104
95ILK0.41749015
96CAMK10.41113249
97MAP3K60.41049154
98CDK150.38236702
99PRKCA0.37895223
100CAMK1D0.37852996

Predicted pathways (KEGG)

RankGene SetZ-score
1* Mineral absorption_Homo sapiens_hsa049784.79122655
2Complement and coagulation cascades_Homo sapiens_hsa046102.81084779
3PPAR signaling pathway_Homo sapiens_hsa033202.26377422
4Staphylococcus aureus infection_Homo sapiens_hsa051502.19438041
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16641914
6Prion diseases_Homo sapiens_hsa050202.11772754
7Pertussis_Homo sapiens_hsa051331.97358506
8Histidine metabolism_Homo sapiens_hsa003401.93194033
9Rheumatoid arthritis_Homo sapiens_hsa053231.89141005
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83440205
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.78438629
12Phenylalanine metabolism_Homo sapiens_hsa003601.74038397
13Arginine biosynthesis_Homo sapiens_hsa002201.71769550
14Other glycan degradation_Homo sapiens_hsa005111.63597956
15Malaria_Homo sapiens_hsa051441.63457410
16Caffeine metabolism_Homo sapiens_hsa002321.62456236
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60559620
18Fatty acid degradation_Homo sapiens_hsa000711.56158533
19Fat digestion and absorption_Homo sapiens_hsa049751.54585184
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.52872511
21Lysosome_Homo sapiens_hsa041421.51695144
22Tryptophan metabolism_Homo sapiens_hsa003801.51413217
23Retinol metabolism_Homo sapiens_hsa008301.47708694
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45706206
25Chemical carcinogenesis_Homo sapiens_hsa052041.43789853
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34730263
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34462279
28Osteoclast differentiation_Homo sapiens_hsa043801.33742278
29Sulfur metabolism_Homo sapiens_hsa009201.31750569
30Tyrosine metabolism_Homo sapiens_hsa003501.30638834
31TNF signaling pathway_Homo sapiens_hsa046681.29500148
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28781907
33Salmonella infection_Homo sapiens_hsa051321.20654160
34Glycerolipid metabolism_Homo sapiens_hsa005611.15953293
35Bile secretion_Homo sapiens_hsa049761.15354963
36Collecting duct acid secretion_Homo sapiens_hsa049661.13726609
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.12780233
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09819117
39Fructose and mannose metabolism_Homo sapiens_hsa000511.02589482
40Legionellosis_Homo sapiens_hsa051341.01382914
41Phagosome_Homo sapiens_hsa041451.01200555
42Synaptic vesicle cycle_Homo sapiens_hsa047210.98058748
43Tuberculosis_Homo sapiens_hsa051520.97792599
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93218027
45African trypanosomiasis_Homo sapiens_hsa051430.92878058
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92428729
47Folate biosynthesis_Homo sapiens_hsa007900.91862937
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.87587899
49Renin-angiotensin system_Homo sapiens_hsa046140.86586469
50Arachidonic acid metabolism_Homo sapiens_hsa005900.85849639
51Fatty acid biosynthesis_Homo sapiens_hsa000610.85268233
52Protein digestion and absorption_Homo sapiens_hsa049740.84919978
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84807124
54Amoebiasis_Homo sapiens_hsa051460.81937609
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81535389
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81103632
57Vitamin digestion and absorption_Homo sapiens_hsa049770.80334278
58Galactose metabolism_Homo sapiens_hsa000520.74984939
59Leishmaniasis_Homo sapiens_hsa051400.74476201
60Glutathione metabolism_Homo sapiens_hsa004800.74020820
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73925736
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73072789
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71060976
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.70986616
65Arginine and proline metabolism_Homo sapiens_hsa003300.70560911
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68779032
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.68509725
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68413684
69Vibrio cholerae infection_Homo sapiens_hsa051100.67979078
70Chemokine signaling pathway_Homo sapiens_hsa040620.67161716
71Vitamin B6 metabolism_Homo sapiens_hsa007500.66943289
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.65136147
73Starch and sucrose metabolism_Homo sapiens_hsa005000.64009503
74beta-Alanine metabolism_Homo sapiens_hsa004100.61192930
75Pyruvate metabolism_Homo sapiens_hsa006200.60423310
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59528333
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58564097
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56005396
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54635881
80Linoleic acid metabolism_Homo sapiens_hsa005910.54340986
81Bladder cancer_Homo sapiens_hsa052190.46714661
82Phototransduction_Homo sapiens_hsa047440.45436810
83Hematopoietic cell lineage_Homo sapiens_hsa046400.42544132
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42432447
85Sulfur relay system_Homo sapiens_hsa041220.40830519
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40320722
87Carbon metabolism_Homo sapiens_hsa012000.39772056
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39462127
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36133733
90Renin secretion_Homo sapiens_hsa049240.33814128
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33029748
92Pentose phosphate pathway_Homo sapiens_hsa000300.30520745
93Sphingolipid metabolism_Homo sapiens_hsa006000.28937096
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28576898
95Hepatitis C_Homo sapiens_hsa051600.28107538
96Insulin resistance_Homo sapiens_hsa049310.27581446
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.25607619
98Peroxisome_Homo sapiens_hsa041460.25456817
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24767859
100GnRH signaling pathway_Homo sapiens_hsa049120.24647483

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