MT1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.78995455
2DNA deamination (GO:0045006)8.34275756
3cellular response to zinc ion (GO:0071294)6.59607616
4glucosamine-containing compound catabolic process (GO:1901072)6.10525898
5cytolysis (GO:0019835)6.00936345
6cell wall macromolecule metabolic process (GO:0044036)5.95773882
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.94624926
8negative regulation of T cell apoptotic process (GO:0070233)5.36604978
9pyrimidine nucleoside catabolic process (GO:0046135)5.16069580
10actin nucleation (GO:0045010)5.12705252
11T cell migration (GO:0072678)5.03927255
12negative regulation of stress fiber assembly (GO:0051497)4.88623034
13negative regulation of viral genome replication (GO:0045071)4.84869579
14positive T cell selection (GO:0043368)4.60302794
15positive regulation of calcium-mediated signaling (GO:0050850)4.55576141
16negative T cell selection (GO:0043383)4.54802128
17production of molecular mediator involved in inflammatory response (GO:0002532)4.47845748
18positive regulation of B cell differentiation (GO:0045579)4.42223594
19regulation of B cell receptor signaling pathway (GO:0050855)4.41659805
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.40076372
21positive regulation of natural killer cell mediated immunity (GO:0002717)4.35777243
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31451816
23sequestering of actin monomers (GO:0042989)4.29066873
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.25658650
25proteasome assembly (GO:0043248)4.13339049
26regulation of activation of Janus kinase activity (GO:0010533)4.01799953
27positive regulation of chemokine secretion (GO:0090197)3.93540292
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.88143572
29regulation of natural killer cell mediated immunity (GO:0002715)3.88143572
30negative regulation of oxidoreductase activity (GO:0051354)3.79403776
31positive regulation of lamellipodium assembly (GO:0010592)3.75502566
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74120253
33ATP synthesis coupled proton transport (GO:0015986)3.74120253
34T cell receptor signaling pathway (GO:0050852)3.73885054
35regulation of T cell receptor signaling pathway (GO:0050856)3.73652563
36purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.72345255
37negative regulation of actin filament bundle assembly (GO:0032232)3.64893828
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.63086077
39positive thymic T cell selection (GO:0045059)3.60171242
40regulation of B cell differentiation (GO:0045577)3.58844133
41negative regulation of lymphocyte apoptotic process (GO:0070229)3.55272068
42amino sugar catabolic process (GO:0046348)3.53359466
43regulation of T cell apoptotic process (GO:0070232)3.48393966
44regulation of viral genome replication (GO:0045069)3.48157525
45respiratory electron transport chain (GO:0022904)3.42396956
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41656547
47electron transport chain (GO:0022900)3.40169826
48regulation of calcium-mediated signaling (GO:0050848)3.39723713
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36079955
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35505267
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.35491583
52regulation of leukocyte mediated cytotoxicity (GO:0001910)3.33379412
53eosinophil chemotaxis (GO:0048245)3.30963441
54regulation of chemokine secretion (GO:0090196)3.30814322
55negative regulation by host of viral transcription (GO:0043922)3.28616564
56response to interferon-beta (GO:0035456)3.27342283
57deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.23492843
58pyrimidine-containing compound catabolic process (GO:0072529)3.21109101
59positive regulation of cell killing (GO:0031343)3.18840877
60positive regulation of interleukin-1 beta secretion (GO:0050718)3.17026355
61T cell costimulation (GO:0031295)3.13633858
62negative regulation of T cell receptor signaling pathway (GO:0050860)3.11796757
63antigen receptor-mediated signaling pathway (GO:0050851)3.10395663
64lymphocyte costimulation (GO:0031294)3.09647317
65macrophage chemotaxis (GO:0048246)3.08044888
66positive regulation of gamma-delta T cell activation (GO:0046645)3.06631877
67T cell selection (GO:0045058)3.03832843
68positive regulation of interleukin-1 secretion (GO:0050716)3.01487363
69thymic T cell selection (GO:0045061)3.00481789
70eosinophil migration (GO:0072677)2.99028453
71regulation of gamma-delta T cell differentiation (GO:0045586)2.97519956
72regulation of T cell chemotaxis (GO:0010819)2.96855179
73positive regulation of T cell chemotaxis (GO:0010820)2.96855179
74negative regulation of nitric-oxide synthase activity (GO:0051001)2.93161233
75ribosomal small subunit assembly (GO:0000028)2.91656507
76regulation of cell killing (GO:0031341)2.90987323
77oxidative phosphorylation (GO:0006119)2.86492496
78cellular response to interleukin-15 (GO:0071350)2.86319332
79positive regulation of tolerance induction (GO:0002645)2.85445189
80regulation of interleukin-1 beta secretion (GO:0050706)2.84585743
81cellular defense response (GO:0006968)2.81631271
82pyrimidine ribonucleoside metabolic process (GO:0046131)2.81183402
83negative thymic T cell selection (GO:0045060)2.79244758
84positive regulation of lamellipodium organization (GO:1902745)2.76632725
85positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75794235
86regulation of T cell tolerance induction (GO:0002664)2.75195686
87negative regulation of viral process (GO:0048525)2.73555190
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72174378
89regulation of lymphocyte chemotaxis (GO:1901623)2.71263290
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69531943
91lymphocyte migration (GO:0072676)2.69175786
92positive regulation of actin filament depolymerization (GO:0030836)2.69023076
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68913856
94regulation of cellular amino acid metabolic process (GO:0006521)2.68660388
95positive regulation of interleukin-4 production (GO:0032753)2.67005302
96positive regulation of defense response to virus by host (GO:0002230)2.66852070
97cytidine metabolic process (GO:0046087)11.1097483
98cytidine catabolic process (GO:0006216)11.1097483
99cytidine deamination (GO:0009972)11.1097483
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.0955413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.57973182
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.15889426
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.39184311
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91990757
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.78634661
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.45047185
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.26942560
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.15060206
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.92211511
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85795912
11MYB_26560356_Chip-Seq_TH2_Human2.60321912
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.36773532
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30199109
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24880649
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20351153
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.18123426
17UTX_26944678_Chip-Seq_JUKART_Human2.17043810
18RUNX_20019798_ChIP-Seq_JUKART_Human2.15935249
19GATA3_27048872_Chip-Seq_THYMUS_Human2.14389972
20VDR_22108803_ChIP-Seq_LS180_Human2.05660336
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00598632
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99989175
23MYB_26560356_Chip-Seq_TH1_Human1.97103821
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89371982
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.82745051
26PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.82713969
27EZH2_22144423_ChIP-Seq_EOC_Human1.74760110
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74050129
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.69376038
30MAF_26560356_Chip-Seq_TH2_Human1.68753393
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66196007
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65565341
33GATA3_26560356_Chip-Seq_TH2_Human1.63524986
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62817927
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57229609
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55504692
37VDR_23849224_ChIP-Seq_CD4+_Human1.54983155
38MAF_26560356_Chip-Seq_TH1_Human1.54264700
39BCL6_27268052_Chip-Seq_Bcells_Human1.53609027
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53241968
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46684326
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43149398
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.42391149
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.39584644
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.37490410
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36302744
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.29285965
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29285965
49HTT_18923047_ChIP-ChIP_STHdh_Human1.28579707
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24240311
51NANOG_20526341_ChIP-Seq_ESCs_Human1.23448443
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23049973
53TAF2_19829295_ChIP-Seq_ESCs_Human1.18104602
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18072670
55P300_27268052_Chip-Seq_Bcells_Human1.16081990
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15562256
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15562256
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15562256
59BCOR_27268052_Chip-Seq_Bcells_Human1.14193056
60BCAT_22108803_ChIP-Seq_LS180_Human1.11663438
61CTCF_20526341_ChIP-Seq_ESCs_Human1.11156247
62NCOR_22424771_ChIP-Seq_293T_Human1.10926804
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.10921591
64TP53_22573176_ChIP-Seq_HFKS_Human1.10353522
65ERG_20517297_ChIP-Seq_VCAP_Human1.09733769
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09287075
67E2F1_20622854_ChIP-Seq_HELA_Human1.07831807
68MYC_19829295_ChIP-Seq_ESCs_Human1.07702299
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.05081770
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03758561
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02826269
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02647720
73FOXP3_21729870_ChIP-Seq_TREG_Human1.02305340
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02284902
75AR_20517297_ChIP-Seq_VCAP_Human1.02057499
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01771812
77GATA6_21074721_ChIP-Seq_CACO-2_Human1.00867917
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00424524
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99487930
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99151985
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96675353
82TRIM28_21343339_ChIP-Seq_HEK293_Human0.95579312
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.95464513
84IGF1R_20145208_ChIP-Seq_DFB_Human0.94325461
85OCT4_20526341_ChIP-Seq_ESCs_Human0.93835463
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93494481
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93270084
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92195757
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92134545
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91819851
91SPI1_23547873_ChIP-Seq_NB4_Human0.91220307
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90349882
93NANOG_19829295_ChIP-Seq_ESCs_Human0.89968981
94SOX2_19829295_ChIP-Seq_ESCs_Human0.89968981
95P53_21459846_ChIP-Seq_SAOS-2_Human0.89939644
96PHF8_20622854_ChIP-Seq_HELA_Human0.88439332
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87257500
98SA1_27219007_Chip-Seq_Bcells_Human0.86990492
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86907500
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85075606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.29355043
2MP0002166_altered_tumor_susceptibility4.11147532
3MP0009785_altered_susceptibility_to3.79416243
4MP0003763_abnormal_thymus_physiology3.76188695
5MP0002006_tumorigenesis3.09676165
6MP0001835_abnormal_antigen_presentation2.78830359
7MP0003646_muscle_fatigue2.72638602
8MP0009333_abnormal_splenocyte_physiolog2.71352548
9MP0005000_abnormal_immune_tolerance2.59190158
10MP0005025_abnormal_response_to2.24104321
11MP0006082_CNS_inflammation2.20564761
12MP0002420_abnormal_adaptive_immunity2.18426870
13MP0001800_abnormal_humoral_immune2.17482810
14MP0003448_altered_tumor_morphology2.07596664
15MP0001819_abnormal_immune_cell2.05185116
16MP0002723_abnormal_immune_serum2.03900364
17MP0003806_abnormal_nucleotide_metabolis1.98331079
18MP0002277_abnormal_respiratory_mucosa1.96355863
19MP0002933_joint_inflammation1.95240421
20MP0002009_preneoplasia1.93953181
21MP0005387_immune_system_phenotype1.91329825
22MP0001790_abnormal_immune_system1.91329825
23MP0003866_abnormal_defecation1.88491493
24MP0003045_fibrosis1.84568906
25MP0002148_abnormal_hypersensitivity_rea1.84083115
26MP0005645_abnormal_hypothalamus_physiol1.79208511
27MP0003011_delayed_dark_adaptation1.77974535
28MP0000703_abnormal_thymus_morphology1.68758392
29MP0000716_abnormal_immune_system1.67088428
30MP0002405_respiratory_system_inflammati1.64881892
31MP0002398_abnormal_bone_marrow1.62901725
32MP0002822_catalepsy1.62416601
33MP0001661_extended_life_span1.55087097
34MP0000685_abnormal_immune_system1.55017884
35MP0002452_abnormal_antigen_presenting1.49260131
36MP0006072_abnormal_retinal_apoptosis1.45339387
37MP0002138_abnormal_hepatobiliary_system1.38479812
38MP0001764_abnormal_homeostasis1.37184556
39MP0002722_abnormal_immune_system1.34708482
40MP0001968_abnormal_touch/_nociception1.34460708
41MP0002736_abnormal_nociception_after1.34214203
42MP0001845_abnormal_inflammatory_respons1.33036671
43MP0008872_abnormal_physiological_respon1.31421618
44MP0004185_abnormal_adipocyte_glucose1.30588663
45MP0001905_abnormal_dopamine_level1.29805509
46MP0000689_abnormal_spleen_morphology1.29384546
47MP0009763_increased_sensitivity_to1.26900924
48MP0010386_abnormal_urinary_bladder1.25155490
49MP0010155_abnormal_intestine_physiology1.24582086
50MP0002429_abnormal_blood_cell1.19994117
51MP0003786_premature_aging1.16407324
52MP0004130_abnormal_muscle_cell1.15715070
53MP0002876_abnormal_thyroid_physiology1.13332024
54MP0000678_abnormal_parathyroid_gland1.11548407
55MP0008469_abnormal_protein_level1.05184026
56MP0005464_abnormal_platelet_physiology1.05032252
57MP0002095_abnormal_skin_pigmentation1.04223430
58MP0001542_abnormal_bone_strength1.03381728
59MP0004036_abnormal_muscle_relaxation1.03228888
60MP0001919_abnormal_reproductive_system1.03187617
61MP0005670_abnormal_white_adipose1.02382351
62MP0005551_abnormal_eye_electrophysiolog1.02264812
63MP0004947_skin_inflammation1.01221101
64MP0005666_abnormal_adipose_tissue1.00424552
65MP0005377_hearing/vestibular/ear_phenot0.97992919
66MP0003878_abnormal_ear_physiology0.97992919
67MP0005085_abnormal_gallbladder_physiolo0.97424955
68MP0009643_abnormal_urine_homeostasis0.97095949
69MP0005253_abnormal_eye_physiology0.96328348
70MP0002419_abnormal_innate_immunity0.94922651
71MP0000858_altered_metastatic_potential0.93538321
72MP0003436_decreased_susceptibility_to0.90272478
73MP0002909_abnormal_adrenal_gland0.88451980
74MP0002837_dystrophic_cardiac_calcinosis0.87110555
75MP0002139_abnormal_hepatobiliary_system0.85159149
76MP0003279_aneurysm0.81537226
77MP0003195_calcinosis0.81314002
78MP0009379_abnormal_foot_pigmentation0.79706600
79MP0001243_abnormal_dermal_layer0.79198963
80MP0003724_increased_susceptibility_to0.78682589
81MP0005503_abnormal_tendon_morphology0.78180495
82MP0005166_decreased_susceptibility_to0.77955548
83MP0005083_abnormal_biliary_tract0.76917103
84MP0002136_abnormal_kidney_physiology0.75947975
85MP0001958_emphysema0.75903179
86MP0002693_abnormal_pancreas_physiology0.73951345
87MP0000639_abnormal_adrenal_gland0.73221702
88MP0002163_abnormal_gland_morphology0.71957912
89MP0004145_abnormal_muscle_electrophysio0.71009023
90MP0008875_abnormal_xenobiotic_pharmacok0.70790048
91MP0009697_abnormal_copulation0.70068191
92MP0001664_abnormal_digestion0.69456220
93MP0005379_endocrine/exocrine_gland_phen0.69147099
94MP0005389_reproductive_system_phenotype0.64974135
95MP0004043_abnormal_pH_regulation0.62761300
96MP0008260_abnormal_autophagy0.61293642
97MP0001873_stomach_inflammation0.61026303
98MP0008873_increased_physiological_sensi0.58530713
99MP0004147_increased_porphyrin_level0.57417786
100MP0000230_abnormal_systemic_arterial0.56957967

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)9.90139377
2T lymphocytopenia (HP:0005403)6.42438215
3Abnormality of T cell number (HP:0011839)5.77082602
4Severe combined immunodeficiency (HP:0004430)4.52497156
5Increased IgM level (HP:0003496)4.49502242
6Autoimmune hemolytic anemia (HP:0001890)4.41803380
73-Methylglutaconic aciduria (HP:0003535)4.11091912
8Abnormality of T cells (HP:0002843)4.11065766
9Hepatocellular necrosis (HP:0001404)3.97837922
10Mitochondrial inheritance (HP:0001427)3.87455211
11Elevated erythrocyte sedimentation rate (HP:0003565)3.85833067
12Combined immunodeficiency (HP:0005387)3.64842808
13IgG deficiency (HP:0004315)3.58822746
14Hepatic necrosis (HP:0002605)3.43047699
15Attenuation of retinal blood vessels (HP:0007843)3.35425890
16Thyroiditis (HP:0100646)3.34583429
17Abnormality of macrophages (HP:0004311)3.32155168
18Amyotrophic lateral sclerosis (HP:0007354)3.23272445
19Abnormality of eosinophils (HP:0001879)3.15247980
20Hypoproteinemia (HP:0003075)3.15072800
21Acute hepatic failure (HP:0006554)3.14572890
22Eosinophilia (HP:0001880)3.12192750
23Encephalitis (HP:0002383)3.11374220
24Recurrent bronchitis (HP:0002837)3.10605086
25Chronic diarrhea (HP:0002028)3.08043131
26Cerebral palsy (HP:0100021)3.00788051
27IgM deficiency (HP:0002850)2.99955296
28Autoimmune thrombocytopenia (HP:0001973)2.96272404
29Acute necrotizing encephalopathy (HP:0006965)2.95057044
30Type I transferrin isoform profile (HP:0003642)2.91297429
31Pancytopenia (HP:0001876)2.85267297
32Increased CSF lactate (HP:0002490)2.84886437
33Hypergammaglobulinemia (HP:0010702)2.83188708
34Abnormal mitochondria in muscle tissue (HP:0008316)2.81468816
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80281595
36Generalized aminoaciduria (HP:0002909)2.73571867
37Lymphopenia (HP:0001888)2.70536460
38Recurrent viral infections (HP:0004429)2.65068336
39Increased hepatocellular lipid droplets (HP:0006565)2.61652277
40Nonimmune hydrops fetalis (HP:0001790)2.57461877
41Lymphoma (HP:0002665)2.56320016
42Progressive macrocephaly (HP:0004481)2.52641350
43B lymphocytopenia (HP:0010976)2.51493012
44Alkalosis (HP:0001948)2.46439646
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.41492491
46Optic disc pallor (HP:0000543)2.38229877
47Lipid accumulation in hepatocytes (HP:0006561)2.36669017
48Granulocytopenia (HP:0001913)2.36656650
49Bronchitis (HP:0012387)2.32707446
50Increased intramyocellular lipid droplets (HP:0012240)2.32594537
51Gastrointestinal infarctions (HP:0005244)2.30579787
52Joint swelling (HP:0001386)2.30332344
53Renal Fanconi syndrome (HP:0001994)2.25677972
54Acute encephalopathy (HP:0006846)2.24541832
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21158342
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21158342
57Congenital stationary night blindness (HP:0007642)2.20546555
58Abnormality of B cell number (HP:0010975)2.19503268
59Leukocytosis (HP:0001974)2.17534682
60Cerebral edema (HP:0002181)2.15066324
61Abnormality of T cell physiology (HP:0011840)2.14656672
62Hyponatremia (HP:0002902)2.14391831
63Hypoplasia of the thymus (HP:0000778)2.09909230
64CNS demyelination (HP:0007305)2.08230458
65Abnormal rod and cone electroretinograms (HP:0008323)2.04771198
66Ulnar deviation of the wrist (HP:0003049)2.04590526
67Palpebral edema (HP:0100540)2.03874039
68Cutaneous melanoma (HP:0012056)1.99992307
69Chronic sinusitis (HP:0011109)1.99815295
70Small epiphyses (HP:0010585)1.97109064
71Oral leukoplakia (HP:0002745)1.95143032
72Amniotic constriction ring (HP:0009775)1.94922737
73Abnormality of placental membranes (HP:0011409)1.94922737
74Tetany (HP:0001281)1.94213733
75Carpal bone hypoplasia (HP:0001498)1.92548008
76Increased muscle lipid content (HP:0009058)1.90835464
77Pancreatic cysts (HP:0001737)1.88445223
78Vertebral compression fractures (HP:0002953)1.88362756
79Hypokalemic alkalosis (HP:0001949)1.88193463
80Abolished electroretinogram (ERG) (HP:0000550)1.87091931
81Respiratory failure (HP:0002878)1.86969345
82Cellular immunodeficiency (HP:0005374)1.86245575
83Abnormality of urine glucose concentration (HP:0011016)1.84291170
84Glycosuria (HP:0003076)1.84291170
85Large eyes (HP:0001090)1.83820190
86Mesangial abnormality (HP:0001966)1.82965930
87Abnormal protein glycosylation (HP:0012346)1.81683290
88Abnormal glycosylation (HP:0012345)1.81683290
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81683290
90Abnormal protein N-linked glycosylation (HP:0012347)1.81683290
91Exertional dyspnea (HP:0002875)1.80378914
92Decreased circulating renin level (HP:0003351)1.77466583
93Bronchiectasis (HP:0002110)1.77437035
94Lactic acidosis (HP:0003128)1.77349781
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73742291
96Hypokalemia (HP:0002900)1.71466578
97Respiratory distress (HP:0002098)1.70697271
98Hyperammonemia (HP:0001987)1.70295402
99Hyperkalemia (HP:0002153)1.64619551
100Congenital sensorineural hearing impairment (HP:0008527)1.64012065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.57872270
2TESK25.76748241
3MAP3K124.86130981
4TESK13.96307494
5MAP4K13.38934112
6SCYL23.38420151
7LIMK13.30407550
8TAOK33.13645606
9MAP3K112.66424404
10TXK2.26324515
11ZAP702.14327207
12BCKDK2.02014645
13MAPKAPK31.91925913
14WNK41.91462078
15FES1.68168599
16ZAK1.67028075
17MYLK1.51842904
18MST41.49799114
19TLK11.30793653
20PRKCQ1.29884974
21ADRBK21.29866010
22MAP3K51.26508557
23CAMKK21.24059314
24CSF1R1.21776439
25ITK1.19557148
26TYRO31.18038326
27ADRBK11.15885324
28DAPK11.14434915
29STK391.12402823
30CSK1.06093174
31LCK1.02445254
32TNK21.00449649
33GRK70.97279567
34SYK0.94707550
35PIK3CA0.93961952
36PIK3CG0.92749178
37BUB10.84007598
38EIF2AK30.82810936
39GRK10.81437128
40VRK20.79154445
41ROCK10.74483701
42NUAK10.73985767
43VRK10.73370869
44CLK10.72425029
45PDGFRB0.71542812
46MAP4K20.68839091
47BTK0.68214035
48DYRK20.65968806
49LMTK20.62738119
50LYN0.62177361
51IKBKE0.59925350
52TAOK20.56252675
53MAPK150.55122681
54OXSR10.52804173
55PRKCH0.50676511
56PRKG20.48745515
57BMPR20.48103167
58INSR0.47876829
59BMX0.46696043
60INSRR0.45474340
61BLK0.45126268
62CAMKK10.44971165
63FYN0.44739857
64AURKA0.44565953
65PIM10.43302688
66MAP2K60.42547234
67ILK0.41678064
68STK380.40900950
69OBSCN0.39820113
70RPS6KA50.38647292
71MAPK130.35443307
72BRSK10.35028446
73TBK10.34747839
74IKBKB0.33708599
75ACVR1B0.32633565
76LRRK20.31985763
77FRK0.30458716
78IGF1R0.28760007
79CDK30.28521040
80PRKCI0.28423168
81STK160.28294934
82PDK10.27761719
83JAK30.26640885
84PAK10.26158898
85PRKCA0.25795184
86GRK50.25076817
87MAPKAPK20.24845237
88TAF10.23619240
89MINK10.23523875
90MAPK110.22076397
91HCK0.21784919
92TEC0.21257412
93MAP2K70.20379044
94BRSK20.19867713
95DAPK30.18643904
96CDK140.16883970
97ATR0.16832538
98PRKD10.16335574
99ABL10.16264980
100TIE10.15010471

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.53800524
2Proteasome_Homo sapiens_hsa030504.18542894
3Oxidative phosphorylation_Homo sapiens_hsa001903.40229320
4Parkinsons disease_Homo sapiens_hsa050123.20096617
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.91969887
6Antigen processing and presentation_Homo sapiens_hsa046122.81630373
7Graft-versus-host disease_Homo sapiens_hsa053322.65323453
8T cell receptor signaling pathway_Homo sapiens_hsa046602.44313896
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42759034
10Alzheimers disease_Homo sapiens_hsa050102.33956548
11Phototransduction_Homo sapiens_hsa047442.28416401
12Hematopoietic cell lineage_Homo sapiens_hsa046402.24390451
13Ribosome_Homo sapiens_hsa030102.09220392
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07669309
15Shigellosis_Homo sapiens_hsa051311.87568398
16Huntingtons disease_Homo sapiens_hsa050161.84924564
17Cardiac muscle contraction_Homo sapiens_hsa042601.75355012
18Mineral absorption_Homo sapiens_hsa049781.67312475
19RNA polymerase_Homo sapiens_hsa030201.63286379
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52891308
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48735038
22Allograft rejection_Homo sapiens_hsa053301.47199220
23Measles_Homo sapiens_hsa051621.46938987
24Salmonella infection_Homo sapiens_hsa051321.44475628
25Autoimmune thyroid disease_Homo sapiens_hsa053201.41439810
26Protein export_Homo sapiens_hsa030601.35886621
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35283018
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.35130107
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30100490
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20044287
31Sulfur metabolism_Homo sapiens_hsa009201.14544461
32Malaria_Homo sapiens_hsa051441.12389615
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11462320
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.11095536
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09302445
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07811462
37Regulation of autophagy_Homo sapiens_hsa041401.04310477
38Type I diabetes mellitus_Homo sapiens_hsa049401.03781169
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02402342
40Peroxisome_Homo sapiens_hsa041460.95870289
41Viral myocarditis_Homo sapiens_hsa054160.95345805
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93113349
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91381047
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90779257
45Retinol metabolism_Homo sapiens_hsa008300.90751932
46Chemical carcinogenesis_Homo sapiens_hsa052040.84669909
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.81410243
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78246644
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77639306
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77299011
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77279695
52Arginine biosynthesis_Homo sapiens_hsa002200.77111793
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76291772
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74826344
55Nitrogen metabolism_Homo sapiens_hsa009100.73482347
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72753286
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.72562472
58Rheumatoid arthritis_Homo sapiens_hsa053230.72364035
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64774183
60Pyrimidine metabolism_Homo sapiens_hsa002400.60525500
61Pertussis_Homo sapiens_hsa051330.59289811
62Prion diseases_Homo sapiens_hsa050200.58847128
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57931252
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51870079
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50312523
66Purine metabolism_Homo sapiens_hsa002300.49017589
67Caffeine metabolism_Homo sapiens_hsa002320.45013977
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44834246
69Herpes simplex infection_Homo sapiens_hsa051680.41016052
70Fatty acid biosynthesis_Homo sapiens_hsa000610.40512749
71Olfactory transduction_Homo sapiens_hsa047400.39973653
72Legionellosis_Homo sapiens_hsa051340.38216295
73Propanoate metabolism_Homo sapiens_hsa006400.37711382
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36808718
75Linoleic acid metabolism_Homo sapiens_hsa005910.35904037
76Butanoate metabolism_Homo sapiens_hsa006500.35470032
77Amphetamine addiction_Homo sapiens_hsa050310.35386984
78Nucleotide excision repair_Homo sapiens_hsa034200.33522933
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.32576606
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30877562
81Metabolic pathways_Homo sapiens_hsa011000.30486937
82Glutathione metabolism_Homo sapiens_hsa004800.30044582
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.29445127
84Complement and coagulation cascades_Homo sapiens_hsa046100.29183967
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28353365
86Epstein-Barr virus infection_Homo sapiens_hsa051690.28196051
87ABC transporters_Homo sapiens_hsa020100.27304980
88PPAR signaling pathway_Homo sapiens_hsa033200.25500268
89Circadian rhythm_Homo sapiens_hsa047100.25144051
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24043298
91Basal transcription factors_Homo sapiens_hsa030220.22792945
92Homologous recombination_Homo sapiens_hsa034400.21872453
93Endocytosis_Homo sapiens_hsa041440.21583231
94Systemic lupus erythematosus_Homo sapiens_hsa053220.21057086
95Fatty acid elongation_Homo sapiens_hsa000620.20968849
96One carbon pool by folate_Homo sapiens_hsa006700.20787641
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19948157
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19302148
99N-Glycan biosynthesis_Homo sapiens_hsa005100.15943853
100Salivary secretion_Homo sapiens_hsa049700.14897671

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