MT1XP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)8.73555889
2spermatid nucleus differentiation (GO:0007289)7.75779002
3transcription from RNA polymerase I promoter (GO:0006360)7.62966114
4ribosomal small subunit assembly (GO:0000028)7.62108514
5diacylglycerol metabolic process (GO:0046339)7.42435420
6negative regulation of execution phase of apoptosis (GO:1900118)6.93657672
7negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)6.49503927
8ncRNA 3-end processing (GO:0043628)6.30194248
9heterotypic cell-cell adhesion (GO:0034113)6.25012631
10protein heterotetramerization (GO:0051290)6.05039621
11xenobiotic catabolic process (GO:0042178)5.82139797
12regulation of metalloenzyme activity (GO:0048552)5.77350333
13ubiquinone biosynthetic process (GO:0006744)5.67686011
14acrosome assembly (GO:0001675)5.30046012
15ubiquinone metabolic process (GO:0006743)5.25922874
16embryonic body morphogenesis (GO:0010172)5.10978647
17deoxyribose phosphate biosynthetic process (GO:0046385)4.98519290
182-deoxyribonucleotide biosynthetic process (GO:0009265)4.98519290
19cell fate commitment involved in formation of primary germ layer (GO:0060795)4.85806579
20cellular anion homeostasis (GO:0030002)4.82749516
21quinone biosynthetic process (GO:1901663)4.78560530
22response to nitrosative stress (GO:0051409)4.67638891
23response to misfolded protein (GO:0051788)4.66502332
24protein polyglutamylation (GO:0018095)4.63064849
25regulation of glycoprotein biosynthetic process (GO:0010559)4.62281990
26endodermal cell differentiation (GO:0035987)4.55161089
27nonmotile primary cilium assembly (GO:0035058)4.53248214
28isoprenoid biosynthetic process (GO:0008299)4.45240647
29histone H2B ubiquitination (GO:0033523)4.43219656
30embryonic process involved in female pregnancy (GO:0060136)4.34189741
31positive regulation of Ras protein signal transduction (GO:0046579)4.21051852
32pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.18647703
33regulation of interleukin-8 secretion (GO:2000482)4.16929921
34receptor clustering (GO:0043113)4.05714515
35leukocyte cell-cell adhesion (GO:0007159)4.03368059
36phosphatidylinositol acyl-chain remodeling (GO:0036149)4.01179001
37body morphogenesis (GO:0010171)4.00249042
38arachidonic acid secretion (GO:0050482)3.99606696
39icosanoid secretion (GO:0032309)3.99606696
40regulation of glycoprotein metabolic process (GO:1903018)3.89233912
41regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.84784170
42positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.82392108
43deoxyribonucleotide biosynthetic process (GO:0009263)3.81392514
44regulation of lipoprotein metabolic process (GO:0050746)3.74990019
45transcription elongation from RNA polymerase I promoter (GO:0006362)3.73522178
46phosphatidylserine acyl-chain remodeling (GO:0036150)3.67073574
47termination of RNA polymerase I transcription (GO:0006363)3.66249178
48glycerophospholipid catabolic process (GO:0046475)3.65083520
49regulation of mRNA 3-end processing (GO:0031440)3.63648766
50phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.63533007
51eosinophil chemotaxis (GO:0048245)3.63439363
52neutrophil activation involved in immune response (GO:0002283)3.56216608
53leukocyte migration involved in inflammatory response (GO:0002523)3.54295849
54fatty acid transmembrane transport (GO:1902001)3.53699748
55granulocyte chemotaxis (GO:0071621)3.53254009
56carnitine shuttle (GO:0006853)3.53155006
57positive regulation of small GTPase mediated signal transduction (GO:0051057)3.51618286
58receptor internalization (GO:0031623)3.48022764
59granulocyte migration (GO:0097530)3.41380080
60neutrophil chemotaxis (GO:0030593)3.41105204
61fatty acid elongation (GO:0030497)3.37867752
62autophagic vacuole fusion (GO:0000046)3.36380386
63protein K48-linked ubiquitination (GO:0070936)3.35755418
64neutrophil migration (GO:1990266)3.34402044
65negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.33707672
66eosinophil migration (GO:0072677)3.30197787
67positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.29637485
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.27788893
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27788893
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27788893
71meiotic chromosome segregation (GO:0045132)3.27357396
72leukotriene biosynthetic process (GO:0019370)3.24947700
73regulation of sister chromatid cohesion (GO:0007063)3.24608768
74positive regulation of mRNA 3-end processing (GO:0031442)3.22597908
75negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)3.22160055
76defense response to fungus (GO:0050832)3.20177206
77relaxation of cardiac muscle (GO:0055119)3.17926869
78positive regulation of endothelial cell apoptotic process (GO:2000353)3.16481916
79regulation of skeletal muscle contraction (GO:0014819)3.15634959
80formation of translation preinitiation complex (GO:0001731)3.14368322
81transcription initiation from RNA polymerase I promoter (GO:0006361)3.12740475
82response to phenylpropanoid (GO:0080184)3.11615069
83fatty acid derivative transport (GO:1901571)3.09916214
84icosanoid transport (GO:0071715)3.09916214
85vitamin catabolic process (GO:0009111)3.09173363
86fat-soluble vitamin catabolic process (GO:0042363)3.09173363
87resolution of meiotic recombination intermediates (GO:0000712)3.03888137
88synaptonemal complex assembly (GO:0007130)3.02192098
89disruption of cells of other organism (GO:0044364)2.99987469
90killing of cells of other organism (GO:0031640)2.99987469
91quinone metabolic process (GO:1901661)2.96672280
92T cell apoptotic process (GO:0070231)2.94754976
93response to auditory stimulus (GO:0010996)2.94272160
94mRNA polyadenylation (GO:0006378)2.91281401
95regulation of spindle checkpoint (GO:0090231)2.90970230
96phosphatidylserine metabolic process (GO:0006658)2.90506034
97RNA polyadenylation (GO:0043631)2.90153729
98regulation of protein glycosylation (GO:0060049)11.7112701
99positive regulation of glycoprotein biosynthetic process (GO:0010560)11.5403370
100positive regulation of glycoprotein metabolic process (GO:1903020)10.0338612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse7.31943523
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.93967115
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.51009968
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.53103844
5EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human3.44829577
6SREBP1_19666523_ChIP-Seq_LIVER_Mouse3.08674572
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.01900701
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.25237070
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.23191697
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21827707
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12547919
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09052828
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94912618
14SOX2_18555785_ChIP-Seq_MESCs_Mouse1.90335553
15TCF4_18268006_ChIP-ChIP_LS174T_Human1.88167163
16VDR_22108803_ChIP-Seq_LS180_Human1.84019148
17CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.79843525
18IRF1_19129219_ChIP-ChIP_H3396_Human1.65706822
19PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.65107271
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62439503
21CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61320206
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.58523249
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54037786
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51107241
25ZNF274_21170338_ChIP-Seq_K562_Hela1.50996492
26AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48949443
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45521441
28GATA1_22025678_ChIP-Seq_K562_Human1.42670204
29BCAT_22108803_ChIP-Seq_LS180_Human1.40460740
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37672177
31IGF1R_20145208_ChIP-Seq_DFB_Human1.36246958
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33507196
33EGR1_19032775_ChIP-ChIP_M12_Human1.31599434
34GATA3_21867929_ChIP-Seq_TH1_Mouse1.30944278
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.30772626
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.30371864
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.25220780
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.24427914
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23805343
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.23662131
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21197135
42GBX2_23144817_ChIP-Seq_PC3_Human1.19948560
43TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19113557
44CBP_20019798_ChIP-Seq_JUKART_Human1.18761000
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18761000
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.18618187
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17590435
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.17129107
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16210348
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15281037
51TAF2_19829295_ChIP-Seq_ESCs_Human1.13060570
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12991408
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.12457492
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07847622
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05055082
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.02619865
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01358613
58SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00231454
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00141066
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98295672
61RUNX_20019798_ChIP-Seq_JUKART_Human0.97915976
62PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97168814
63RNF2_27304074_Chip-Seq_NSC_Mouse0.97142365
64SOX2_19829295_ChIP-Seq_ESCs_Human0.96343390
65NANOG_19829295_ChIP-Seq_ESCs_Human0.96343390
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96074234
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95899463
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95522504
69GATA3_26560356_Chip-Seq_TH2_Human0.94091522
70BCL6_27268052_Chip-Seq_Bcells_Human0.93692378
71ER_23166858_ChIP-Seq_MCF-7_Human0.92925320
72FUS_26573619_Chip-Seq_HEK293_Human0.91780960
73MYC_19829295_ChIP-Seq_ESCs_Human0.90243511
74OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89851389
75POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88885691
76VDR_23849224_ChIP-Seq_CD4+_Human0.86478840
77STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86457898
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83337507
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82305320
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81991997
81RUNX2_22187159_ChIP-Seq_PCA_Human0.80808107
82CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79807563
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79412724
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.79101430
85FLI1_21867929_ChIP-Seq_TH2_Mouse0.78528222
86GATA3_26560356_Chip-Seq_TH1_Human0.77208936
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.75586175
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.74511111
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74504594
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.74389765
91LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.73995030
92SOX2_21211035_ChIP-Seq_LN229_Human0.73348324
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72901265
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70257891
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.69809853
96CEBPB_22108803_ChIP-Seq_LS180_Human0.69173169
97TP53_18474530_ChIP-ChIP_U2OS_Human0.68610962
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.68403374
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.68248063
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68014767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation4.64268002
2MP0008260_abnormal_autophagy4.46832784
3MP0001851_eye_inflammation4.41655162
4MP0001529_abnormal_vocalization3.96667778
5MP0003646_muscle_fatigue3.37928882
6MP0006082_CNS_inflammation3.11233337
7MP0005253_abnormal_eye_physiology2.83845084
8MP0010386_abnormal_urinary_bladder2.83649747
9MP0006292_abnormal_olfactory_placode2.51896936
10MP0003011_delayed_dark_adaptation2.39545566
11MP0005197_abnormal_uvea_morphology2.32143638
12MP0001905_abnormal_dopamine_level2.26713871
13MP0004142_abnormal_muscle_tone2.21537165
14MP0003195_calcinosis2.02065231
15MP0005595_abnormal_vascular_smooth1.98867300
16MP0001191_abnormal_skin_condition1.98088509
17MP0004924_abnormal_behavior1.91074872
18MP0005386_behavior/neurological_phenoty1.91074872
19MP0004947_skin_inflammation1.89196677
20MP0002876_abnormal_thyroid_physiology1.85876478
21MP0003690_abnormal_glial_cell1.83805726
22MP0003724_increased_susceptibility_to1.80457235
23MP0009046_muscle_twitch1.76657472
24MP0006035_abnormal_mitochondrial_morpho1.75760065
25MP0003880_abnormal_central_pattern1.68731638
26MP0001727_abnormal_embryo_implantation1.64572381
27MP0002277_abnormal_respiratory_mucosa1.63349951
28MP0000049_abnormal_middle_ear1.56990625
29MP0005408_hypopigmentation1.55442562
30MP0008875_abnormal_xenobiotic_pharmacok1.50935891
31MP0004885_abnormal_endolymph1.47840879
32MP0006276_abnormal_autonomic_nervous1.45117132
33MP0000230_abnormal_systemic_arterial1.44243977
34MP0005391_vision/eye_phenotype1.43264968
35MP0003943_abnormal_hepatobiliary_system1.40797130
36MP0006036_abnormal_mitochondrial_physio1.39382695
37MP0008789_abnormal_olfactory_epithelium1.37809562
38MP0002837_dystrophic_cardiac_calcinosis1.35857169
39MP0002877_abnormal_melanocyte_morpholog1.34476402
40MP0002419_abnormal_innate_immunity1.31753128
41MP0005000_abnormal_immune_tolerance1.31480407
42MP0005025_abnormal_response_to1.31393844
43MP0000462_abnormal_digestive_system1.29135800
44MP0008873_increased_physiological_sensi1.24764651
45MP0002160_abnormal_reproductive_system1.22033229
46MP0000372_irregular_coat_pigmentation1.21636405
47MP0005645_abnormal_hypothalamus_physiol1.15121267
48MP0008469_abnormal_protein_level1.15068296
49MP0005670_abnormal_white_adipose1.14085441
50MP0005193_abnormal_anterior_eye1.12650224
51MP0000013_abnormal_adipose_tissue1.11593535
52MP0002115_abnormal_skeleton_extremities1.11099336
53MP0003937_abnormal_limbs/digits/tail_de1.10590886
54MP0005646_abnormal_pituitary_gland1.10371437
55MP0001486_abnormal_startle_reflex1.08778249
56MP0008872_abnormal_physiological_respon1.07998242
57MP0005499_abnormal_olfactory_system1.06384445
58MP0005394_taste/olfaction_phenotype1.06384445
59MP0001502_abnormal_circadian_rhythm1.03621147
60MP0008877_abnormal_DNA_methylation1.03341990
61MP0001293_anophthalmia0.98189847
62MP0001324_abnormal_eye_pigmentation0.97806325
63MP0005187_abnormal_penis_morphology0.94021415
64MP0004484_altered_response_of0.93692348
65MP0003938_abnormal_ear_development0.92548492
66MP0002210_abnormal_sex_determination0.92386080
67MP0003567_abnormal_fetal_cardiomyocyte0.91994853
68MP0000377_abnormal_hair_follicle0.90510773
69MP0000367_abnormal_coat/_hair0.90192724
70MP0005551_abnormal_eye_electrophysiolog0.90188477
71MP0005195_abnormal_posterior_eye0.90110055
72MP0002723_abnormal_immune_serum0.89472799
73MP0002102_abnormal_ear_morphology0.87614366
74MP0000920_abnormal_myelination0.84730294
75MP0004381_abnormal_hair_follicle0.83093630
76MP0001845_abnormal_inflammatory_respons0.82638922
77MP0001800_abnormal_humoral_immune0.82631742
78MP0005423_abnormal_somatic_nervous0.81582205
79MP0005671_abnormal_response_to0.80874610
80MP0000778_abnormal_nervous_system0.80355740
81MP0001929_abnormal_gametogenesis0.78873963
82MP0002557_abnormal_social/conspecific_i0.77469530
83MP0008995_early_reproductive_senescence0.76611420
84MP0005636_abnormal_mineral_homeostasis0.73193803
85MP0002148_abnormal_hypersensitivity_rea0.71326988
86MP0009278_abnormal_bone_marrow0.69302169
87MP0001835_abnormal_antigen_presentation0.67974678
88MP0002572_abnormal_emotion/affect_behav0.67887612
89MP0000538_abnormal_urinary_bladder0.66733060
90MP0002751_abnormal_autonomic_nervous0.66364090
91MP0002168_other_aberrant_phenotype0.66302992
92MP0000653_abnormal_sex_gland0.65696340
93MP0002452_abnormal_antigen_presenting0.64819427
94MP0000750_abnormal_muscle_regeneration0.64178366
95MP0002822_catalepsy0.64020333
96MP0002971_abnormal_brown_adipose0.61763298
97MP0001145_abnormal_male_reproductive0.60316933
98MP0003755_abnormal_palate_morphology0.59920151
99MP0009745_abnormal_behavioral_response0.59353330
100MP0001873_stomach_inflammation0.59238983

Predicted human phenotypes

RankGene SetZ-score
1Periodontitis (HP:0000704)8.95637820
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.20612438
3Sparse scalp hair (HP:0002209)6.14167234
4Recurrent abscess formation (HP:0002722)6.12411441
5Abnormality of the intervertebral disk (HP:0005108)5.98565333
6Gingivitis (HP:0000230)5.96743442
7Chronic bronchitis (HP:0004469)5.79101396
8Leukocytosis (HP:0001974)5.70844889
9Deep philtrum (HP:0002002)5.56906029
10Nasal speech (HP:0001611)5.41724817
11Aplasia/Hypoplasia of the sacrum (HP:0008517)5.37072799
12Autoimmune thrombocytopenia (HP:0001973)4.46607118
13Autoimmune hemolytic anemia (HP:0001890)4.16248260
14Eosinophilia (HP:0001880)3.97562878
15Abnormality of macular pigmentation (HP:0008002)3.79703545
16Cupped ribs (HP:0000887)3.75692106
17Cerebellar dysplasia (HP:0007033)3.68912149
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.62923018
19Abnormal respiratory motile cilium physiology (HP:0012261)3.58768107
20Increased IgM level (HP:0003496)3.37073655
21Rhinitis (HP:0012384)3.22279537
22Papilledema (HP:0001085)3.16787306
23Absent hand (HP:0004050)3.04798563
24Granulocytopenia (HP:0001913)3.03498430
25Cortical visual impairment (HP:0100704)2.97020398
26Maternal diabetes (HP:0009800)2.93646261
27Abnormality of eosinophils (HP:0001879)2.85256362
28Attenuation of retinal blood vessels (HP:0007843)2.81654656
29Hypoplastic toenails (HP:0001800)2.79206039
30Hypoproteinemia (HP:0003075)2.78077430
31Cone-rod dystrophy (HP:0000548)2.63224124
32Metaphyseal cupping (HP:0003021)2.62718507
33Atrioventricular block (HP:0001678)2.60389722
34Pulmonic stenosis (HP:0001642)2.56739729
35Status epilepticus (HP:0002133)2.55618522
36Broad distal phalanx of finger (HP:0009836)2.51044198
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50133306
383-Methylglutaconic aciduria (HP:0003535)2.37231375
39Asplenia (HP:0001746)2.37182758
40Lower limb asymmetry (HP:0100559)2.31519993
41Hypochromic anemia (HP:0001931)2.26203605
42Acute necrotizing encephalopathy (HP:0006965)2.21971672
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.20414929
44Myelomeningocele (HP:0002475)2.20339166
45Recurrent otitis media (HP:0000403)2.20229069
46Bronchitis (HP:0012387)2.16791578
47Partial agenesis of the corpus callosum (HP:0001338)2.15122557
48Webbed neck (HP:0000465)2.12002200
49Abnormal mitochondria in muscle tissue (HP:0008316)2.06981575
5011 pairs of ribs (HP:0000878)2.06205138
51Progressive macrocephaly (HP:0004481)2.04260301
52Aplasia/hypoplasia of the uterus (HP:0008684)2.04248916
53Anencephaly (HP:0002323)2.02729537
54Abnormality of magnesium homeostasis (HP:0004921)2.01028472
55Recurrent gram-negative bacterial infections (HP:0005420)11.9218137
56Bony spicule pigmentary retinopathy (HP:0007737)1.96423739
57Abolished electroretinogram (ERG) (HP:0000550)1.90438815
58Optic disc pallor (HP:0000543)1.82030479
59Aplasia/Hypoplasia of the fovea (HP:0008060)1.80899609
60Hypoplasia of the fovea (HP:0007750)1.80899609
61Submucous cleft hard palate (HP:0000176)1.78494952
62Acute encephalopathy (HP:0006846)1.78375267
63Abnormality of binocular vision (HP:0011514)1.77086121
64Diplopia (HP:0000651)1.77086121
65Rhabdomyosarcoma (HP:0002859)1.76138224
66Abnormality of T cell physiology (HP:0011840)1.76097445
67Prominent forehead (HP:0011220)1.71035792
68Abnormality of the tricuspid valve (HP:0001702)1.68822703
69Nephronophthisis (HP:0000090)1.68818906
70Microcytic anemia (HP:0001935)1.68183005
71Optic nerve hypoplasia (HP:0000609)1.68108961
72Hemiplegia (HP:0002301)1.66408899
73Abnormality of the fovea (HP:0000493)1.66373982
74Pendular nystagmus (HP:0012043)1.65369658
75Bronchiectasis (HP:0002110)1.64759001
76Chorioretinal atrophy (HP:0000533)1.63876264
77Abnormality of T cell number (HP:0011839)1.63671558
78Heart block (HP:0012722)1.61933115
79Amelogenesis imperfecta (HP:0000705)1.61618678
80Pulmonary embolism (HP:0002204)1.60785239
81Pancreatic cysts (HP:0001737)1.58866315
82Tibial bowing (HP:0002982)1.58564692
83Hyponatremia (HP:0002902)1.58001454
84Type I transferrin isoform profile (HP:0003642)1.57982171
85Hyperglycinemia (HP:0002154)1.56453457
86Achilles tendon contracture (HP:0001771)1.55867498
87Hypsarrhythmia (HP:0002521)1.55803854
88Hypoplasia of the uterus (HP:0000013)1.54907430
89Constricted visual fields (HP:0001133)1.54222346
90Abnormality of the Achilles tendon (HP:0005109)1.54026763
91Oligodactyly (hands) (HP:0001180)1.49952659
92Subcapsular cataract (HP:0000523)1.49596257
93Ulnar claw (HP:0001178)1.48775852
94Low posterior hairline (HP:0002162)1.48763185
95Hypoplastic ilia (HP:0000946)1.46164979
96EEG with generalized epileptiform discharges (HP:0011198)1.44477424
97Nonprogressive disorder (HP:0003680)1.43976630
98Abnormality of DNA repair (HP:0003254)1.41725871
99Intention tremor (HP:0002080)1.40555125
100Radial bowing (HP:0002986)1.39755666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.53744629
2PRKCH6.59114578
3ICK3.65751793
4TYRO32.86571804
5FES2.74630795
6TXK2.61917034
7MAP4K12.30225761
8DAPK12.29439444
9EPHA32.19450808
10MAP4K21.98380939
11EPHB11.73632898
12TAOK31.50320044
13NTRK31.43017359
14CSK1.42213179
15MAPK131.38490540
16RAF11.25702062
17PKN11.25153169
18KSR21.21817110
19SRPK11.20358078
20KSR11.19885626
21CCNB11.19431697
22MAPK41.17922727
23MAP3K21.17574546
24NLK1.15986464
25BRSK21.14504528
26CASK1.07404722
27WEE11.05927194
28ADRBK11.00712742
29DYRK20.98078025
30WNK30.97303975
31FRK0.96192470
32IRAK10.93729292
33CAMK2B0.92422164
34LCK0.88861911
35EPHA40.88722986
36MAP3K10.85998509
37BCKDK0.83876375
38TRIM280.83265250
39PRKCQ0.82504213
40MAP3K110.81860539
41MAP2K30.81718606
42MAP3K80.78850008
43CAMK2D0.78537809
44ALK0.73849897
45STK390.72882039
46PRKCD0.69338976
47ERBB30.67024928
48MAP2K60.65459987
49CAMK2G0.65172191
50CAMK2A0.63698170
51INSRR0.61900354
52ERBB20.61857831
53BCR0.61405119
54ZAK0.58014958
55PLK40.57005518
56RET0.56797548
57RPS6KA20.55396948
58NUAK10.54333621
59PLK10.52554541
60PDK20.51953870
61GSK3A0.51665076
62GRK10.49952492
63MAP2K40.48808262
64MAPKAPK20.48341363
65FLT30.45578507
66MARK30.44961308
67FER0.44411451
68PRKCB0.44322511
69ATM0.44022906
70MINK10.41774344
71RPS6KA60.41506685
72RPS6KC10.41061680
73RPS6KL10.41061680
74ARAF0.40299387
75STK40.40227263
76SRC0.38509434
77JAK20.37406316
78MAP2K10.36282299
79PRKCG0.35707174
80MARK10.33443382
81MAP3K130.31607888
82PRKACA0.30889414
83PKN20.30292101
84OXSR10.29188463
85MAPKAPK50.29026914
86PDK10.27970866
87FGFR40.27345957
88BUB10.27217202
89CSNK1E0.26233822
90BRSK10.25695388
91MAPK30.25558821
92PLK30.24811958
93OBSCN0.24737129
94PAK30.24534588
95DYRK1B0.24500670
96WNK40.23511599
97IGF1R0.21827022
98RPS6KA50.20386781
99PRKCA0.18838461
100EIF2AK20.17469496

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030206.59814467
2Legionellosis_Homo sapiens_hsa051343.70887486
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.55811527
4Malaria_Homo sapiens_hsa051443.44498339
5Viral myocarditis_Homo sapiens_hsa054163.27457050
6Staphylococcus aureus infection_Homo sapiens_hsa051503.09379032
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89842643
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.81332649
9Pertussis_Homo sapiens_hsa051332.23423032
10Leishmaniasis_Homo sapiens_hsa051402.20088280
11Type I diabetes mellitus_Homo sapiens_hsa049402.11802969
12Linoleic acid metabolism_Homo sapiens_hsa005912.10786986
13Autoimmune thyroid disease_Homo sapiens_hsa053202.09814985
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08267716
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05341674
16Graft-versus-host disease_Homo sapiens_hsa053321.98834876
17Allograft rejection_Homo sapiens_hsa053301.94299999
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.86167144
19Rheumatoid arthritis_Homo sapiens_hsa053231.71975285
20Glycerolipid metabolism_Homo sapiens_hsa005611.70191673
21Pyrimidine metabolism_Homo sapiens_hsa002401.63309460
22Complement and coagulation cascades_Homo sapiens_hsa046101.58974458
23Purine metabolism_Homo sapiens_hsa002301.52757538
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.49440901
25Non-small cell lung cancer_Homo sapiens_hsa052231.44838935
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35322066
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29101161
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.26509702
29Fat digestion and absorption_Homo sapiens_hsa049751.26077485
30Glutathione metabolism_Homo sapiens_hsa004801.18313748
31Fatty acid elongation_Homo sapiens_hsa000621.16465195
32Parkinsons disease_Homo sapiens_hsa050121.04697037
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01254719
34Spliceosome_Homo sapiens_hsa030400.97446338
35Arachidonic acid metabolism_Homo sapiens_hsa005900.94769885
36Amoebiasis_Homo sapiens_hsa051460.92515296
37Chemical carcinogenesis_Homo sapiens_hsa052040.91366850
38Ether lipid metabolism_Homo sapiens_hsa005650.89907982
39Dorso-ventral axis formation_Homo sapiens_hsa043200.89735901
40Choline metabolism in cancer_Homo sapiens_hsa052310.89341050
41Basal transcription factors_Homo sapiens_hsa030220.83726754
42African trypanosomiasis_Homo sapiens_hsa051430.82667836
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81341642
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79140304
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78536287
46Primary immunodeficiency_Homo sapiens_hsa053400.67986099
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67706860
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67518158
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.66248767
50Phagosome_Homo sapiens_hsa041450.66248735
51Measles_Homo sapiens_hsa051620.63354367
52Caffeine metabolism_Homo sapiens_hsa002320.61803872
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61733513
54Ribosome_Homo sapiens_hsa030100.57990506
55Phototransduction_Homo sapiens_hsa047440.57667621
56FoxO signaling pathway_Homo sapiens_hsa040680.56447706
57Olfactory transduction_Homo sapiens_hsa047400.56144290
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54932941
59Ras signaling pathway_Homo sapiens_hsa040140.52422662
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51693940
61Huntingtons disease_Homo sapiens_hsa050160.51577349
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51463469
63Prion diseases_Homo sapiens_hsa050200.50458407
64Tuberculosis_Homo sapiens_hsa051520.49768151
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48319237
66Nitrogen metabolism_Homo sapiens_hsa009100.47601020
67Colorectal cancer_Homo sapiens_hsa052100.44631267
68Nicotine addiction_Homo sapiens_hsa050330.42598451
69Butanoate metabolism_Homo sapiens_hsa006500.38002628
70ABC transporters_Homo sapiens_hsa020100.36446477
71Hematopoietic cell lineage_Homo sapiens_hsa046400.35628377
72Oxidative phosphorylation_Homo sapiens_hsa001900.35415550
73RNA degradation_Homo sapiens_hsa030180.34748375
74Synaptic vesicle cycle_Homo sapiens_hsa047210.34180291
75Endometrial cancer_Homo sapiens_hsa052130.32048638
76Hippo signaling pathway_Homo sapiens_hsa043900.30418965
77N-Glycan biosynthesis_Homo sapiens_hsa005100.27767104
78Melanoma_Homo sapiens_hsa052180.26275959
79Acute myeloid leukemia_Homo sapiens_hsa052210.23164603
80Serotonergic synapse_Homo sapiens_hsa047260.22217827
81Rap1 signaling pathway_Homo sapiens_hsa040150.21815586
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21480058
83Metabolic pathways_Homo sapiens_hsa011000.18892460
84Taste transduction_Homo sapiens_hsa047420.17551080
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15662170
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15395559
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15253283
88Fanconi anemia pathway_Homo sapiens_hsa034600.14394026
89RNA transport_Homo sapiens_hsa030130.13677251
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13047116
91Oocyte meiosis_Homo sapiens_hsa041140.12728311
92Protein export_Homo sapiens_hsa030600.12630252
93Fatty acid biosynthesis_Homo sapiens_hsa000610.11525370
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.11003665
95Hedgehog signaling pathway_Homo sapiens_hsa043400.10386205
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09835147
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09049460
98HTLV-I infection_Homo sapiens_hsa051660.08469991
99T cell receptor signaling pathway_Homo sapiens_hsa046600.07898487
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06650674

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