ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to cadmium ion (GO:0071276)	9.28523679
2	nucleobase-containing small molecule interconversion (GO:0015949)	4.64907360
3	membrane raft organization (GO:0031579)	4.61617485
4	type B pancreatic cell proliferation (GO:0044342)	4.52932600
5	hemidesmosome assembly (GO:0031581)	4.49646927
6	ribosomal small subunit biogenesis (GO:0042274)	4.45077010
7	regulation of metalloenzyme activity (GO:0048552)	4.20103032
8	response to cadmium ion (GO:0046686)	4.12479062
9	* response to zinc ion (GO:0010043)	4.00379549
10	protein maturation by protein folding (GO:0022417)	3.96496635
11	ribosomal large subunit biogenesis (GO:0042273)	3.95228422
12	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.91100770
13	pyrimidine nucleoside salvage (GO:0043097)	3.77716588
14	pyrimidine-containing compound salvage (GO:0008655)	3.77716588
15	negative regulation of response to reactive oxygen species (GO:1901032)	3.68852625
16	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.66480471
17	fibrinolysis (GO:0042730)	3.60059692
18	protein heterotetramerization (GO:0051290)	3.52649098
19	nucleotide-sugar biosynthetic process (GO:0009226)	3.44081744
20	cell adhesion mediated by integrin (GO:0033627)	3.43476993
21	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.41567615
22	proteasome assembly (GO:0043248)	3.31788048
23	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.30153381
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.29180039
25	protein targeting to ER (GO:0045047)	3.28568340
26	nucleoside salvage (GO:0043174)	3.26146989
27	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.25418623
28	cotranslational protein targeting to membrane (GO:0006613)	3.23616671
29	regulation of plasminogen activation (GO:0010755)	3.21886938
30	viral transcription (GO:0019083)	3.21723469
31	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.20581870
32	skin morphogenesis (GO:0043589)	3.19694100
33	GDP-mannose metabolic process (GO:0019673)	3.19154712
34	membrane budding (GO:0006900)	3.16346721
35	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.16238229
36	protein localization to endoplasmic reticulum (GO:0070972)	3.15884632
37	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.14840890
38	regulation of integrin-mediated signaling pathway (GO:2001044)	3.12964068
39	response to redox state (GO:0051775)	3.09251387
40	chaperone-mediated protein transport (GO:0072321)	3.08333107
41	translational termination (GO:0006415)	3.08094884
42	regulation of vitamin D biosynthetic process (GO:0060556)	3.06093386
43	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.04306031
44	ribonucleoprotein complex biogenesis (GO:0022613)	3.00747912
45	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.00715423
46	cyclooxygenase pathway (GO:0019371)	2.98588231
47	protein localization to endosome (GO:0036010)	2.98482010
48	negative regulation of anoikis (GO:2000811)	2.97011856
49	nuclear envelope reassembly (GO:0031468)	2.90223603
50	mitotic nuclear envelope reassembly (GO:0007084)	2.90223603
51	regulation of mitotic spindle organization (GO:0060236)	2.85556958
52	translation (GO:0006412)	2.83809578
53	regulation of protein export from nucleus (GO:0046825)	2.77823047
54	endodermal cell differentiation (GO:0035987)	2.77255810
55	barbed-end actin filament capping (GO:0051016)	2.72491321
56	desmosome organization (GO:0002934)	2.72342678
57	regulation of vitamin metabolic process (GO:0030656)	2.70720548
58	viral life cycle (GO:0019058)	2.69778320
59	cellular response to interferon-alpha (GO:0035457)	2.68335631
60	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.67591297
61	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.65411988
62	cell-substrate junction assembly (GO:0007044)	2.65128583
63	regulation of spindle organization (GO:0090224)	2.63300987
64	establishment of viral latency (GO:0019043)	2.61655686
65	translational elongation (GO:0006414)	2.60328476
66	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.58630687
67	establishment of integrated proviral latency (GO:0075713)	2.58621151
68	AMP metabolic process (GO:0046033)	2.58474741
69	nucleotide salvage (GO:0043173)	2.58321883
70	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.57454229
71	negative regulation of ligase activity (GO:0051352)	2.57454229
72	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.56691425
73	protein targeting to membrane (GO:0006612)	2.56210941
74	regulation of anoikis (GO:2000209)	2.56060930
75	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.54453742
76	translational initiation (GO:0006413)	2.53717923
77	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.51846015
78	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.51437252
79	UMP metabolic process (GO:0046049)	2.51437252
80	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.51437252
81	UMP biosynthetic process (GO:0006222)	2.51437252
82	ATP synthesis coupled proton transport (GO:0015986)	2.50645089
83	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.50645089
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.47878784
85	regulation of cellular amino acid metabolic process (GO:0006521)	2.46957885
86	protein targeting to mitochondrion (GO:0006626)	2.46861630
87	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.46652813
88	deoxyribose phosphate biosynthetic process (GO:0046385)	2.46652813
89	negative regulation of fibrinolysis (GO:0051918)	2.45134879
90	response to copper ion (GO:0046688)	2.44755237
91	natural killer cell mediated immunity (GO:0002228)	2.44739362
92	natural killer cell mediated cytotoxicity (GO:0042267)	2.44739362
93	activation of protein kinase B activity (GO:0032148)	2.43852871
94	parturition (GO:0007567)	2.43757160
95	mitotic metaphase plate congression (GO:0007080)	2.42745512
96	rRNA modification (GO:0000154)	2.42236540
97	ribosome assembly (GO:0042255)	2.40826207
98	Golgi transport vesicle coating (GO:0048200)	2.39737720
99	COPI coating of Golgi vesicle (GO:0048205)	2.39737720
100	* cellular response to zinc ion (GO:0071294)	13.6319213

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	7.87450735
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.58260552
3	* SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.66726579
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.82943650
5	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.68401851
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.66503329
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.58884398
8	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.43404490
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.37235308
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.36564577
11	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	2.32767389
12	AR_21909140_ChIP-Seq_LNCAP_Human	2.31339707
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.30586114
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.20280061
15	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.20100000
16	* SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.04846840
17	* SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.04846840
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.00516046
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.94911459
20	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.94404404
21	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.87237431
22	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.85476993
23	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.85208276
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82477881
25	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.81876671
26	ZNF263_19887448_ChIP-Seq_K562_Human	1.80187651
27	* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.78813033
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.78508629
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.76915141
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76797601
31	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.73605582
32	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.73063129
33	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.71117296
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.70953199
35	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.69812598
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.68441379
37	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.68426414
38	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.67731037
39	* ATF3_27146783_Chip-Seq_COLON_Human	1.62875084
40	CLOCK_20551151_ChIP-Seq_293T_Human	1.60881759
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.60600997
42	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.60390020
43	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.59316639
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59108651
45	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.57108979
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50998232
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49954814
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48786285
49	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.48323947
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.47495282
51	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.45099758
52	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45007354
53	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.44782243
54	BRD4_25478319_ChIP-Seq_HGPS_Human	1.44282267
55	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.36568204
56	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.34650909
57	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.32264185
58	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.30939946
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28898517
60	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.26876317
61	* CJUN_26792858_Chip-Seq_BT549_Human	1.26628613
62	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.25940059
63	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.23212691
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.22003855
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.20000414
66	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.19567590
67	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.18786413
68	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.18260411
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.17915383
70	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15897958
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.14405858
72	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.13516748
73	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.13211707
74	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.12831241
75	GABP_19822575_ChIP-Seq_HepG2_Human	1.11832705
76	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.11659703
77	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.11017803
78	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.09214009
79	* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08930410
80	TFEB_21752829_ChIP-Seq_HELA_Human	1.07094520
81	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.07024461
82	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.06774151
83	* GATA2_21666600_ChIP-Seq_HMVEC_Human	1.06558674
84	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.04620811
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02886265
86	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02031503
87	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.01361428
88	* SOX2_20726797_ChIP-Seq_SW620_Human	1.01211327
89	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00849774
90	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.00702381
91	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.98571043
92	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.98404989
93	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.97536684
94	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.97444224
95	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.97321309
96	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95554459
97	ELF5_23300383_ChIP-Seq_T47D_Human	0.94696820
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93486245
99	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.92784942
100	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92611065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.50955052
2	MP0003950_abnormal_plasma_membrane	4.96089044
3	MP0003705_abnormal_hypodermis_morpholog	4.22103079
4	MP0010368_abnormal_lymphatic_system	3.60792550
5	MP0008438_abnormal_cutaneous_collagen	3.51757059
6	MP0005360_urolithiasis	2.81807625
7	MP0003566_abnormal_cell_adhesion	2.65791354
8	MP0003191_abnormal_cellular_cholesterol	2.56611201
9	MP0005023_abnormal_wound_healing	2.51279886
10	MP0009780_abnormal_chondrocyte_physiolo	2.32865237
11	MP0001853_heart_inflammation	2.29876421
12	MP0010030_abnormal_orbit_morphology	2.28437837
13	MP0004272_abnormal_basement_membrane	2.27034130
14	MP0005623_abnormal_meninges_morphology	2.25834410
15	MP0006054_spinal_hemorrhage	2.22997190
16	MP0004510_myositis	2.15456158
17	MP0001879_abnormal_lymphatic_vessel	2.14057017
18	MP0003941_abnormal_skin_development	2.06167310
19	MP0003186_abnormal_redox_activity	1.96395876
20	MP0003279_aneurysm	1.95838200
21	MP0002060_abnormal_skin_morphology	1.90019354
22	MP0003453_abnormal_keratinocyte_physiol	1.71996969
23	MP0009840_abnormal_foam_cell	1.70367768
24	MP0002877_abnormal_melanocyte_morpholog	1.68400957
25	MP0000858_altered_metastatic_potential	1.65696252
26	MP0000343_altered_response_to	1.65550358
27	MP0005257_abnormal_intraocular_pressure	1.59279758
28	MP0001542_abnormal_bone_strength	1.56879549
29	MP0003091_abnormal_cell_migration	1.56254697
30	MP0005164_abnormal_response_to	1.55038849
31	MP0009053_abnormal_anal_canal	1.54369590
32	MP0000750_abnormal_muscle_regeneration	1.51338247
33	MP0005275_abnormal_skin_tensile	1.50455703
34	MP0000762_abnormal_tongue_morphology	1.48553096
35	MP0005451_abnormal_body_composition	1.43682711
36	MP0008007_abnormal_cellular_replicative	1.39765668
37	MP0002295_abnormal_pulmonary_circulatio	1.36753399
38	MP0009697_abnormal_copulation	1.34235057
39	MP0003075_altered_response_to	1.31815675
40	MP0001216_abnormal_epidermal_layer	1.31496542
41	MP0008260_abnormal_autophagy	1.18513303
42	MP0001958_emphysema	1.18163484
43	MP0000678_abnormal_parathyroid_gland	1.18038031
44	MP0005501_abnormal_skin_physiology	1.17519232
45	MP0002332_abnormal_exercise_endurance	1.15776554
46	MP0005165_increased_susceptibility_to	1.14869811
47	MP0005330_cardiomyopathy	1.13230865
48	MP0005670_abnormal_white_adipose	1.12368652
49	MP0005595_abnormal_vascular_smooth	1.11487901
50	MP0003448_altered_tumor_morphology	1.09478129
51	MP0000733_abnormal_muscle_development	1.07292332
52	MP0002796_impaired_skin_barrier	1.06979793
53	MP0000749_muscle_degeneration	1.06667470
54	MP0004883_abnormal_blood_vessel	1.04529295
55	MP0009379_abnormal_foot_pigmentation	1.01992813
56	MP0004947_skin_inflammation	1.00241326
57	MP0003828_pulmonary_edema	0.98864443
58	MP0000013_abnormal_adipose_tissue	0.98519690
59	MP0002148_abnormal_hypersensitivity_rea	0.97821728
60	MP0001243_abnormal_dermal_layer	0.97214932
61	MP0001849_ear_inflammation	0.94454315
62	MP0005166_decreased_susceptibility_to	0.93721928
63	MP0001881_abnormal_mammary_gland	0.90782008
64	MP0002896_abnormal_bone_mineralization	0.89950233
65	MP0006036_abnormal_mitochondrial_physio	0.88918137
66	MP0010771_integument_phenotype	0.85889810
67	MP0010352_gastrointestinal_tract_polyps	0.84622134
68	MP0005375_adipose_tissue_phenotype	0.82585306
69	MP0000358_abnormal_cell_content/	0.82489989
70	MP0002234_abnormal_pharynx_morphology	0.81026911
71	MP0003077_abnormal_cell_cycle	0.80396707
72	MP0004233_abnormal_muscle_weight	0.79200769
73	MP0000579_abnormal_nail_morphology	0.78906113
74	MP0004957_abnormal_blastocyst_morpholog	0.78033203
75	MP0009785_altered_susceptibility_to	0.76894388
76	MP0005193_abnormal_anterior_eye	0.73917463
77	MP0005666_abnormal_adipose_tissue	0.72956401
78	MP0005621_abnormal_cell_physiology	0.72825794
79	MP0003011_delayed_dark_adaptation	0.72365117
80	MP0002938_white_spotting	0.71101658
81	MP0000767_abnormal_smooth_muscle	0.70265858
82	MP0009763_increased_sensitivity_to	0.68300128
83	MP0005058_abnormal_lysosome_morphology	0.68101924
84	MP0000350_abnormal_cell_proliferation	0.68062850
85	MP0005508_abnormal_skeleton_morphology	0.66734713
86	MP0005584_abnormal_enzyme/coenzyme_acti	0.66523008
87	MP0001851_eye_inflammation	0.63618247
88	MP0009931_abnormal_skin_appearance	0.63174605
89	MP0000759_abnormal_skeletal_muscle	0.62340157
90	MP0005197_abnormal_uvea_morphology	0.61833691
91	MP0000003_abnormal_adipose_tissue	0.61792636
92	MP0000627_abnormal_mammary_gland	0.61382744
93	MP0009250_abnormal_appendicular_skeleto	0.60901440
94	MP0003045_fibrosis	0.60894901
95	MP0005395_other_phenotype	0.60744794
96	MP0003786_premature_aging	0.60191187
97	MP0009764_decreased_sensitivity_to	0.59981722
98	MP0010234_abnormal_vibrissa_follicle	0.59947105
99	MP0008875_abnormal_xenobiotic_pharmacok	0.59942364
100	MP0005408_hypopigmentation	0.59911352

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	3.95661243
2	Atrophic scars (HP:0001075)	3.88353964
3	Reduced subcutaneous adipose tissue (HP:0003758)	3.62516549
4	Onycholysis (HP:0001806)	3.41900021
5	Ankle contracture (HP:0006466)	3.33773375
6	Axonal loss (HP:0003447)	3.31076777
7	Abnormality of the intrinsic pathway (HP:0010989)	3.26420769
8	Protrusio acetabuli (HP:0003179)	3.20954148
9	Fragile nails (HP:0001808)	3.18282406
10	Amniotic constriction ring (HP:0009775)	3.14894864
11	Abnormality of placental membranes (HP:0011409)	3.14894864
12	Milia (HP:0001056)	3.12418058
13	Vertebral compression fractures (HP:0002953)	3.05972790
14	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.02185586
15	Nail dystrophy (HP:0008404)	3.01493376
16	Follicular hyperkeratosis (HP:0007502)	2.89732750
17	Generalized amyotrophy (HP:0003700)	2.75895554
18	Acute necrotizing encephalopathy (HP:0006965)	2.75030878
19	Vascular tortuosity (HP:0004948)	2.73324175
20	Rough bone trabeculation (HP:0100670)	2.71878923
21	Fragile skin (HP:0001030)	2.71328800
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.69668041
23	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.65533082
24	Natal tooth (HP:0000695)	2.62416226
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.62011898
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.62011898
27	Reduced antithrombin III activity (HP:0001976)	2.58533122
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.56378188
29	Alopecia of scalp (HP:0002293)	2.55493255
30	Lip pit (HP:0100267)	2.54366143
31	Decreased subcutaneous fat (HP:0001002)	2.53692102
32	Cardiovascular calcification (HP:0011915)	2.50607453
33	Congenital ichthyosiform erythroderma (HP:0007431)	2.48789581
34	Osteolytic defects of the hand bones (HP:0009699)	2.44334843
35	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.44334843
36	Cervical subluxation (HP:0003308)	2.41306038
37	Type I transferrin isoform profile (HP:0003642)	2.40225444
38	Vascular calcification (HP:0004934)	2.38380533
39	Short nail (HP:0001799)	2.35241206
40	Sparse eyelashes (HP:0000653)	2.31727820
41	Stenosis of the external auditory canal (HP:0000402)	2.29677940
42	Spinal cord compression (HP:0002176)	2.29040797
43	Spinal rigidity (HP:0003306)	2.28438721
44	Renal Fanconi syndrome (HP:0001994)	2.25051181
45	Glucose intolerance (HP:0000833)	2.24728761
46	Abnormalities of placenta or umbilical cord (HP:0001194)	2.22921475
47	Abnormal trabecular bone morphology (HP:0100671)	2.22582960
48	Progressive macrocephaly (HP:0004481)	2.21092485
49	Thick nail (HP:0001805)	2.19429654
50	Wormian bones (HP:0002645)	2.18566223
51	Posterior subcapsular cataract (HP:0007787)	2.17453394
52	Acute encephalopathy (HP:0006846)	2.17011184
53	Neoplasm of head and neck (HP:0012288)	2.16996391
54	Esophageal neoplasm (HP:0100751)	2.16996391
55	Prolonged partial thromboplastin time (HP:0003645)	2.14564315
56	Entropion (HP:0000621)	2.13592918
57	Trismus (HP:0000211)	2.13553377
58	Mitochondrial inheritance (HP:0001427)	2.10597725
59	Bone cyst (HP:0012062)	2.09904077
60	Elbow flexion contracture (HP:0002987)	2.07541918
61	Distal lower limb muscle weakness (HP:0009053)	2.06890928
62	Palpitations (HP:0001962)	2.05681505
63	Plantar hyperkeratosis (HP:0007556)	2.02877965
64	Abnormality of subcutaneous fat tissue (HP:0001001)	2.01498765
65	Distal lower limb amyotrophy (HP:0008944)	2.00946958
66	Achilles tendon contracture (HP:0001771)	2.00562710
67	Testicular atrophy (HP:0000029)	2.00485261
68	Macrocytic anemia (HP:0001972)	2.00158045
69	Hypertensive crisis (HP:0100735)	1.99791212
70	Renal duplication (HP:0000075)	1.97317774
71	Generalized aminoaciduria (HP:0002909)	1.96954953
72	Hypoplasia of dental enamel (HP:0006297)	1.96339564
73	Aortic aneurysm (HP:0004942)	1.95574258
74	Conjunctival hamartoma (HP:0100780)	1.93866271
75	Hyperparathyroidism (HP:0000843)	1.93389405
76	Acanthosis nigricans (HP:0000956)	1.92771886
77	Abnormality of methionine metabolism (HP:0010901)	1.92242998
78	Blue sclerae (HP:0000592)	1.90769472
79	Arterial tortuosity (HP:0005116)	1.90559633
80	Abnormality of the umbilical cord (HP:0010881)	1.90247722
81	Oral leukoplakia (HP:0002745)	1.83797882
82	Abnormal gallbladder physiology (HP:0012438)	1.83245187
83	Cholecystitis (HP:0001082)	1.83245187
84	Abnormality of the Achilles tendon (HP:0005109)	1.83143043
85	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83045321
86	Aortic dissection (HP:0002647)	1.81215834
87	Exercise intolerance (HP:0003546)	1.78082608
88	Insulin resistance (HP:0000855)	1.77662522
89	Chondrocalcinosis (HP:0000934)	1.76867891
90	Abnormality of complement system (HP:0005339)	1.75310835
91	Abnormality of carpal bone ossification (HP:0006257)	1.75200075
92	Poikiloderma (HP:0001029)	1.74540893
93	Exertional dyspnea (HP:0002875)	1.74352829
94	Bladder diverticulum (HP:0000015)	1.73472934
95	Abnormality of Sharpey fibers (HP:0100685)	1.73242263
96	Abnormal number of erythroid precursors (HP:0012131)	1.73025927
97	Brittle hair (HP:0002299)	1.72963928
98	Increased CSF lactate (HP:0002490)	1.70201962
99	Hypoplastic pelvis (HP:0008839)	1.70088373
100	Abnormal blistering of the skin (HP:0008066)	1.69934625

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	4.09242895
2	NME2	3.62721309
3	IRAK3	3.17401926
4	MAP3K12	3.02071037
5	BUB1	2.92723820
6	PAK4	2.73862071
7	PIM2	2.71345511
8	NEK1	2.47797765
9	TESK1	2.41014194
10	PTK2	2.31262799
11	MST1R	2.28796646
12	MST4	2.26980598
13	LATS2	2.25143614
14	MYLK	2.22760079
15	MAP3K3	2.21497534
16	MOS	2.21371339
17	ABL2	2.15072434
18	EPHA2	2.06776199
19	TGFBR2	2.06540901
20	LIMK1	2.02965176
21	MET	1.88403964
22	EPHB2	1.87630305
23	PDGFRA	1.75302157
24	ERBB4	1.73504603
25	EIF2AK1	1.66573732
26	RIPK1	1.66095542
27	ILK	1.62330334
28	STK16	1.61411311
29	LMTK2	1.54961927
30	VRK2	1.52719750
31	BRAF	1.52585541
32	PBK	1.50658576
33	FLT3	1.49404237
34	NTRK1	1.34841424
35	STK10	1.25980332
36	ERN1	1.22778479
37	DDR2	1.21038860
38	TAOK2	1.20321821
39	EIF2AK3	1.07447369
40	PAK2	1.06508988
41	EPHB1	0.98714871
42	CLK1	0.97934587
43	PRPF4B	0.93085669
44	PDK2	0.85075100
45	PAK1	0.76706518
46	PRKG2	0.76520625
47	AURKA	0.75528016
48	GRK7	0.75013422
49	CDK8	0.71334127
50	MAP3K9	0.70253975
51	MAP3K8	0.69014920
52	RAF1	0.68733375
53	TESK2	0.68357591
54	PAK6	0.68196134
55	MUSK	0.67227456
56	DMPK	0.66211884
57	TTN	0.64925177
58	PRKCI	0.63047778
59	ADRBK1	0.62640831
60	STK24	0.62010646
61	ROCK2	0.61812246
62	STK38	0.60793597
63	PTK2B	0.58722495
64	CCNB1	0.57172865
65	MAP2K3	0.56421506
66	MAP3K13	0.55799207
67	CDK9	0.51036401
68	GSK3A	0.50377816
69	PHKG1	0.49134919
70	PHKG2	0.49134919
71	DAPK3	0.49132317
72	EIF2AK2	0.49107624
73	AKT2	0.49077948
74	CDC7	0.48756884
75	BRSK1	0.47385964
76	AURKB	0.46961484
77	CAMK2G	0.46917236
78	BMX	0.43626836
79	ROCK1	0.43556061
80	NEK2	0.43174244
81	TBK1	0.42800223
82	BCKDK	0.40963366
83	PDGFRB	0.40187460
84	TRIB3	0.39011271
85	NEK9	0.38117978
86	SIK1	0.37887719
87	NME1	0.36456994
88	DAPK1	0.32785164
89	PLK1	0.32449677
90	GRK5	0.30115566
91	MAPKAPK2	0.29604453
92	MELK	0.28241008
93	STK4	0.27558963
94	LRRK2	0.27319071
95	SRPK1	0.24930430
96	CSNK1A1L	0.24161315
97	CDC42BPA	0.23665189
98	PLK3	0.23607949
99	PRKD2	0.22822933
100	PTK6	0.22230879

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.53469454
2	Proteasome_Homo sapiens_hsa03050	4.04222155
3	* Mineral absorption_Homo sapiens_hsa04978	3.63166645
4	Protein export_Homo sapiens_hsa03060	2.93772642
5	Nucleotide excision repair_Homo sapiens_hsa03420	2.68453301
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67941425
7	Sulfur metabolism_Homo sapiens_hsa00920	2.59017587
8	Folate biosynthesis_Homo sapiens_hsa00790	2.11417638
9	Parkinsons disease_Homo sapiens_hsa05012	2.05517565
10	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.95385740
11	Glutathione metabolism_Homo sapiens_hsa00480	1.92301587
12	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.86385592
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74398152
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.71696077
15	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.70843982
16	Alzheimers disease_Homo sapiens_hsa05010	1.70280845
17	DNA replication_Homo sapiens_hsa03030	1.67306617
18	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.66857974
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66656128
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.63329367
21	Huntingtons disease_Homo sapiens_hsa05016	1.55851701
22	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.51857265
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.49626059
24	Shigellosis_Homo sapiens_hsa05131	1.48311424
25	Mismatch repair_Homo sapiens_hsa03430	1.43859533
26	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.40288019
27	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.40157218
28	Complement and coagulation cascades_Homo sapiens_hsa04610	1.38135076
29	ECM-receptor interaction_Homo sapiens_hsa04512	1.35304606
30	RNA polymerase_Homo sapiens_hsa03020	1.32010533
31	Galactose metabolism_Homo sapiens_hsa00052	1.31377225
32	Salmonella infection_Homo sapiens_hsa05132	1.29055525
33	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.26185201
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24243911
35	Pentose phosphate pathway_Homo sapiens_hsa00030	1.19219082
36	One carbon pool by folate_Homo sapiens_hsa00670	1.18403951
37	Sulfur relay system_Homo sapiens_hsa04122	1.16920856
38	Focal adhesion_Homo sapiens_hsa04510	1.12485098
39	Vibrio cholerae infection_Homo sapiens_hsa05110	1.11374610
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11047126
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.03020515
42	Prion diseases_Homo sapiens_hsa05020	0.99643749
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98954943
44	p53 signaling pathway_Homo sapiens_hsa04115	0.95773105
45	Proteoglycans in cancer_Homo sapiens_hsa05205	0.91689480
46	Homologous recombination_Homo sapiens_hsa03440	0.83643476
47	Small cell lung cancer_Homo sapiens_hsa05222	0.82603795
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81356191
49	Bladder cancer_Homo sapiens_hsa05219	0.81078271
50	Pertussis_Homo sapiens_hsa05133	0.81063019
51	Base excision repair_Homo sapiens_hsa03410	0.78580300
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74954323
53	Malaria_Homo sapiens_hsa05144	0.74949803
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.70819724
55	TNF signaling pathway_Homo sapiens_hsa04668	0.67783128
56	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.67535793
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67171321
58	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.66602744
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.64867063
60	Amoebiasis_Homo sapiens_hsa05146	0.64136746
61	Legionellosis_Homo sapiens_hsa05134	0.64093157
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61547782
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59567359
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59496840
65	Renal cell carcinoma_Homo sapiens_hsa05211	0.58768431
66	Circadian rhythm_Homo sapiens_hsa04710	0.58154875
67	Basal transcription factors_Homo sapiens_hsa03022	0.56856830
68	PPAR signaling pathway_Homo sapiens_hsa03320	0.56139952
69	Carbon metabolism_Homo sapiens_hsa01200	0.55794335
70	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54815441
71	Apoptosis_Homo sapiens_hsa04210	0.54006097
72	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.52600201
73	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.52306824
74	Endocytosis_Homo sapiens_hsa04144	0.50251830
75	African trypanosomiasis_Homo sapiens_hsa05143	0.49296963
76	Fatty acid elongation_Homo sapiens_hsa00062	0.48783505
77	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.47505713
78	Metabolic pathways_Homo sapiens_hsa01100	0.46567167
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.43200403
80	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42172756
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41827163
82	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41218721
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.40945674
84	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.40664320
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39976983
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39798459
87	Cell cycle_Homo sapiens_hsa04110	0.37515157
88	RNA transport_Homo sapiens_hsa03013	0.35853281
89	Purine metabolism_Homo sapiens_hsa00230	0.35636556
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35128789
91	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.34663342
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33879304
93	Fatty acid degradation_Homo sapiens_hsa00071	0.32816375
94	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.32740438
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31240048
96	Adherens junction_Homo sapiens_hsa04520	0.31039570
97	Lysosome_Homo sapiens_hsa04142	0.30998886
98	Spliceosome_Homo sapiens_hsa03040	0.30372795
99	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.30050594
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29102602

MT2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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