MT2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.62601045
2cytidine metabolic process (GO:0046087)7.58548136
3cytidine catabolic process (GO:0006216)7.58548136
4cytidine deamination (GO:0009972)7.58548136
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.80075539
6cellular response to zinc ion (GO:0071294)6.46889934
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.27430121
8DNA deamination (GO:0045006)6.24988988
9ATP synthesis coupled proton transport (GO:0015986)5.66269692
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.66269692
11ribosomal small subunit assembly (GO:0000028)5.31720166
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09907701
13Arp2/3 complex-mediated actin nucleation (GO:0034314)4.82819242
14respiratory electron transport chain (GO:0022904)4.72991149
15electron transport chain (GO:0022900)4.62995920
16cytolysis (GO:0019835)4.52112365
17sequestering of actin monomers (GO:0042989)4.36154469
18actin nucleation (GO:0045010)4.35688356
19positive regulation of calcium-mediated signaling (GO:0050850)4.34662949
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.20050079
21negative regulation of T cell apoptotic process (GO:0070233)4.08627483
22response to interferon-beta (GO:0035456)4.05867214
23positive regulation of natural killer cell mediated immunity (GO:0002717)4.05811420
24protein complex biogenesis (GO:0070271)4.02126864
25negative regulation of viral genome replication (GO:0045071)3.85116367
26negative regulation of stress fiber assembly (GO:0051497)3.76011401
27viral transcription (GO:0019083)3.73105993
28negative T cell selection (GO:0043383)3.69448006
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.66481183
30hydrogen ion transmembrane transport (GO:1902600)3.64357203
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.61997658
32positive regulation of tolerance induction (GO:0002645)3.59345226
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.58704941
34translational termination (GO:0006415)3.56308133
35mitochondrial respiratory chain complex assembly (GO:0033108)3.54127200
36protein targeting to ER (GO:0045047)3.53699282
37protein neddylation (GO:0045116)3.50650655
38regulation of cellular amino acid metabolic process (GO:0006521)3.49982028
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47287173
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44866779
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44857118
42cotranslational protein targeting to membrane (GO:0006613)3.44771449
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.39735535
44purine deoxyribonucleotide catabolic process (GO:0009155)3.39282956
45protein localization to endoplasmic reticulum (GO:0070972)3.38370611
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33786596
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33656810
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33629032
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33629032
50cellular response to cadmium ion (GO:0071276)3.33424437
51regulation of natural killer cell mediated immunity (GO:0002715)3.30836963
52regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.30836963
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29582704
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29582704
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29582704
56respiratory chain complex IV assembly (GO:0008535)3.28920734
57cytochrome complex assembly (GO:0017004)3.28747820
58positive regulation of defense response to virus by host (GO:0002230)3.28560339
59translational elongation (GO:0006414)3.26317640
60proton transport (GO:0015992)3.26004062
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22730454
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22730454
63pyrimidine nucleoside catabolic process (GO:0046135)3.21754969
64ribosomal small subunit biogenesis (GO:0042274)3.19541617
65positive regulation of fatty acid oxidation (GO:0046321)3.18789254
66hydrogen transport (GO:0006818)3.17974699
67macrophage chemotaxis (GO:0048246)3.16313913
68eosinophil chemotaxis (GO:0048245)3.15272573
69maturation of SSU-rRNA (GO:0030490)3.14648401
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14415942
71negative regulation of ligase activity (GO:0051352)3.14405788
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14405788
73regulation of leukocyte mediated cytotoxicity (GO:0001910)3.11652085
74negative regulation of lymphocyte apoptotic process (GO:0070229)3.10303464
75ATP biosynthetic process (GO:0006754)3.10196816
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.10000296
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10000296
78positive regulation of cell killing (GO:0031343)3.09578218
79positive regulation of fatty acid beta-oxidation (GO:0032000)3.08580810
80proteasome assembly (GO:0043248)3.07602797
81regulation of T cell tolerance induction (GO:0002664)3.06982889
82positive regulation of T cell mediated cytotoxicity (GO:0001916)3.06601448
83positive regulation of gamma-delta T cell activation (GO:0046645)3.06583337
84negative regulation of oxidoreductase activity (GO:0051354)3.06017539
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.03816729
86negative regulation by host of viral transcription (GO:0043922)2.99249349
87regulation of calcium-mediated signaling (GO:0050848)2.98304513
88positive regulation of smooth muscle cell migration (GO:0014911)2.92532593
89T cell migration (GO:0072678)2.92381298
90mannosylation (GO:0097502)2.92106993
91regulation of viral genome replication (GO:0045069)2.89624561
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88197736
93negative regulation of nitric-oxide synthase activity (GO:0051001)2.87709436
94regulation of T cell receptor signaling pathway (GO:0050856)2.87528374
95eosinophil migration (GO:0072677)2.86696731
96antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.86488675
97positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.83522632
98chaperone-mediated protein transport (GO:0072321)2.82823690
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.82150877
100purine deoxyribonucleotide metabolic process (GO:0009151)2.82035932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.05130930
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99606841
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.78705078
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26175314
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.19375940
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16738942
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13871970
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.99420182
9EZH2_22144423_ChIP-Seq_EOC_Human2.95796950
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.90042928
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77578987
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.65169633
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59459475
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.43268957
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24418903
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23940442
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04575604
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98100056
19PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.91206183
20MYB_26560356_Chip-Seq_TH2_Human1.85452943
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.83814528
22ELK1_22589737_ChIP-Seq_MCF10A_Human1.83130295
23VDR_23849224_ChIP-Seq_CD4+_Human1.80988730
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.72027363
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70781138
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69542413
27VDR_22108803_ChIP-Seq_LS180_Human1.69343942
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68711821
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.68349810
30HTT_18923047_ChIP-ChIP_STHdh_Human1.67201849
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.62291051
32GBX2_23144817_ChIP-Seq_PC3_Human1.52365004
33GATA3_27048872_Chip-Seq_THYMUS_Human1.51594694
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51543874
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48724360
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48442993
37ELK1_19687146_ChIP-ChIP_HELA_Human1.46540645
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45813410
39RUNX_20019798_ChIP-Seq_JUKART_Human1.43614360
40ZNF274_21170338_ChIP-Seq_K562_Hela1.42953393
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41853961
42GATA3_26560356_Chip-Seq_TH2_Human1.41546981
43TP53_22573176_ChIP-Seq_HFKS_Human1.36890508
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34416059
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34300968
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31705079
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.31705079
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31237752
49NANOG_20526341_ChIP-Seq_ESCs_Human1.29781110
50ERG_20517297_ChIP-Seq_VCAP_Human1.28510900
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24584418
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24182250
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23576299
54AR_20517297_ChIP-Seq_VCAP_Human1.23521146
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22951294
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22705828
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.21648863
58MYB_26560356_Chip-Seq_TH1_Human1.21450150
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19772227
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19625309
61ER_23166858_ChIP-Seq_MCF-7_Human1.19025427
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15178077
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.15070761
64BCAT_22108803_ChIP-Seq_LS180_Human1.13716473
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13168893
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.11223169
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10626019
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09948292
69TAF2_19829295_ChIP-Seq_ESCs_Human1.08432531
70FOXP3_21729870_ChIP-Seq_TREG_Human1.08084357
71MYC_18940864_ChIP-ChIP_HL60_Human1.06834875
72GATA6_21074721_ChIP-Seq_CACO-2_Human1.05370095
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03982672
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03261027
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.02349584
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02217978
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.00548781
78NANOG_19829295_ChIP-Seq_ESCs_Human1.00466875
79SOX2_19829295_ChIP-Seq_ESCs_Human1.00466875
80MYC_19829295_ChIP-Seq_ESCs_Human0.99601130
81UTX_26944678_Chip-Seq_JUKART_Human0.99516886
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99275923
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98846596
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98177452
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98026599
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97632182
87CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97369037
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96218446
89PHF8_20622853_ChIP-Seq_HELA_Human0.95515552
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.94692622
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.94402929
92CTCF_20526341_ChIP-Seq_ESCs_Human0.94028496
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93653691
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92190347
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92083021
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91620073
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90639632
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90540161
99BCL6_27268052_Chip-Seq_Bcells_Human0.88893482
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88284308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.69388576
2MP0008438_abnormal_cutaneous_collagen4.62088794
3MP0005503_abnormal_tendon_morphology4.24109556
4MP0003646_muscle_fatigue3.94948600
5MP0003279_aneurysm3.21793875
6MP0009785_altered_susceptibility_to3.10653125
7MP0003763_abnormal_thymus_physiology2.74400702
8MP0003011_delayed_dark_adaptation2.69217742
9MP0001835_abnormal_antigen_presentation2.38370363
10MP0002166_altered_tumor_susceptibility2.30086844
11MP0005275_abnormal_skin_tensile2.24191510
12MP0001958_emphysema2.09023542
13MP0005387_immune_system_phenotype2.02743912
14MP0001790_abnormal_immune_system2.02743912
15MP0009333_abnormal_splenocyte_physiolog2.00255134
16MP0005000_abnormal_immune_tolerance1.89635458
17MP0001661_extended_life_span1.82497800
18MP0005171_absent_coat_pigmentation1.74443344
19MP0002277_abnormal_respiratory_mucosa1.73256218
20MP0002933_joint_inflammation1.73139114
21MP0005025_abnormal_response_to1.71813625
22MP0002006_tumorigenesis1.71738218
23MP0002876_abnormal_thyroid_physiology1.71531249
24MP0002148_abnormal_hypersensitivity_rea1.71511239
25MP0010386_abnormal_urinary_bladder1.65064284
26MP0003195_calcinosis1.64796734
27MP0000685_abnormal_immune_system1.63599537
28MP0001800_abnormal_humoral_immune1.63026858
29MP0001542_abnormal_bone_strength1.62644582
30MP0003045_fibrosis1.59440806
31MP0002420_abnormal_adaptive_immunity1.54544308
32MP0002723_abnormal_immune_serum1.53677862
33MP0001243_abnormal_dermal_layer1.48966755
34MP0003786_premature_aging1.48945592
35MP0001819_abnormal_immune_cell1.45877311
36MP0003448_altered_tumor_morphology1.43912159
37MP0000569_abnormal_digit_pigmentation1.40708088
38MP0004145_abnormal_muscle_electrophysio1.37775975
39MP0002736_abnormal_nociception_after1.34109794
40MP0009379_abnormal_foot_pigmentation1.34057445
41MP0005360_urolithiasis1.33651313
42MP0005645_abnormal_hypothalamus_physiol1.32411506
43MP0006082_CNS_inflammation1.31787101
44MP0002405_respiratory_system_inflammati1.30294100
45MP0003866_abnormal_defecation1.29393861
46MP0002163_abnormal_gland_morphology1.27765358
47MP0002452_abnormal_antigen_presenting1.25701592
48MP0004130_abnormal_muscle_cell1.18134071
49MP0002108_abnormal_muscle_morphology1.15912025
50MP0002102_abnormal_ear_morphology1.15397507
51MP0000372_irregular_coat_pigmentation1.15216279
52MP0008995_early_reproductive_senescence1.12409996
53MP0001853_heart_inflammation1.10847469
54MP0005670_abnormal_white_adipose1.08476500
55MP0002282_abnormal_trachea_morphology1.07292524
56MP0000716_abnormal_immune_system1.05299509
57MP0005551_abnormal_eye_electrophysiolog1.03757472
58MP0001845_abnormal_inflammatory_respons1.03260749
59MP0002095_abnormal_skin_pigmentation0.98826444
60MP0009250_abnormal_appendicular_skeleto0.96141676
61MP0001968_abnormal_touch/_nociception0.93489964
62MP0004947_skin_inflammation0.92971053
63MP0004272_abnormal_basement_membrane0.92767297
64MP0002398_abnormal_bone_marrow0.92124251
65MP0009763_increased_sensitivity_to0.89570404
66MP0002060_abnormal_skin_morphology0.88960342
67MP0002168_other_aberrant_phenotype0.88925276
68MP0008875_abnormal_xenobiotic_pharmacok0.87899920
69MP0005174_abnormal_tail_pigmentation0.87620045
70MP0003186_abnormal_redox_activity0.85534411
71MP0010155_abnormal_intestine_physiology0.84703999
72MP0006072_abnormal_retinal_apoptosis0.84399993
73MP0001905_abnormal_dopamine_level0.84276079
74MP0008872_abnormal_physiological_respon0.83828975
75MP0008469_abnormal_protein_level0.83590672
76MP0002722_abnormal_immune_system0.82963127
77MP0009764_decreased_sensitivity_to0.82828037
78MP0004185_abnormal_adipocyte_glucose0.82490110
79MP0000751_myopathy0.81191746
80MP0005646_abnormal_pituitary_gland0.80359135
81MP0000689_abnormal_spleen_morphology0.79195063
82MP0006054_spinal_hemorrhage0.78756444
83MP0005389_reproductive_system_phenotype0.78616090
84MP0000703_abnormal_thymus_morphology0.78025298
85MP0004883_abnormal_blood_vessel0.75127678
86MP0002419_abnormal_innate_immunity0.75033610
87MP0005253_abnormal_eye_physiology0.74818677
88MP0002136_abnormal_kidney_physiology0.72318333
89MP0002295_abnormal_pulmonary_circulatio0.72276000
90MP0001119_abnormal_female_reproductive0.71951295
91MP0002429_abnormal_blood_cell0.71419098
92MP0005379_endocrine/exocrine_gland_phen0.71271574
93MP0004134_abnormal_chest_morphology0.70923911
94MP0010329_abnormal_lipoprotein_level0.69743983
95MP0002160_abnormal_reproductive_system0.67643253
96MP0004043_abnormal_pH_regulation0.67524146
97MP0001919_abnormal_reproductive_system0.66962913
98MP0005390_skeleton_phenotype0.66718661
99MP0005408_hypopigmentation0.66026836
100MP0002115_abnormal_skeleton_extremities0.65754356

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.94374056
2Mitochondrial inheritance (HP:0001427)4.46902140
3T lymphocytopenia (HP:0005403)4.33023725
4Renal Fanconi syndrome (HP:0001994)4.30288560
5Increased hepatocellular lipid droplets (HP:0006565)4.28689258
6Hepatocellular necrosis (HP:0001404)4.27485986
7Abnormality of T cell number (HP:0011839)4.08653391
8Increased intramyocellular lipid droplets (HP:0012240)4.05501694
9Lipid accumulation in hepatocytes (HP:0006561)3.87050382
10Hepatic necrosis (HP:0002605)3.77483905
11Elevated erythrocyte sedimentation rate (HP:0003565)3.70544807
12Increased IgM level (HP:0003496)3.51586356
13Increased CSF lactate (HP:0002490)3.50748764
14Acute necrotizing encephalopathy (HP:0006965)3.45757989
15Increased muscle lipid content (HP:0009058)3.40262734
16Recurrent bronchitis (HP:0002837)3.38336280
17Abnormal mitochondria in muscle tissue (HP:0008316)3.37179660
18Exertional dyspnea (HP:0002875)3.35551599
19IgG deficiency (HP:0004315)3.34245369
20Autoimmune hemolytic anemia (HP:0001890)3.30216822
21Severe combined immunodeficiency (HP:0004430)3.25482281
22Small epiphyses (HP:0010585)3.19712866
23Sensory axonal neuropathy (HP:0003390)3.19650953
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19183544
25Acute hepatic failure (HP:0006554)3.19182466
26Generalized aminoaciduria (HP:0002909)3.03318893
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01437017
28Abnormality of renal resorption (HP:0011038)2.99746688
29Hypoproteinemia (HP:0003075)2.98402127
30Progressive macrocephaly (HP:0004481)2.97080946
313-Methylglutaconic aciduria (HP:0003535)2.94487916
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88741252
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88741252
34Abnormality of cells of the erythroid lineage (HP:0012130)2.82444727
35Thyroiditis (HP:0100646)2.80160451
36Abnormal number of erythroid precursors (HP:0012131)2.71184821
37Spontaneous abortion (HP:0005268)2.67361188
38Acute encephalopathy (HP:0006846)2.66879467
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61098526
40Irregular epiphyses (HP:0010582)2.55411550
41Eosinophilia (HP:0001880)2.53962801
42Ulnar deviation of the wrist (HP:0003049)2.53513971
43Pancreatic cysts (HP:0001737)2.49848246
44Combined immunodeficiency (HP:0005387)2.49191333
45Abnormality of T cells (HP:0002843)2.47563498
46Abnormality of eosinophils (HP:0001879)2.46314898
47Pancytopenia (HP:0001876)2.39464749
48Increased serum lactate (HP:0002151)2.39322840
49Lactic acidosis (HP:0003128)2.38762509
50Partial duplication of the phalanx of hand (HP:0009999)2.34687654
51Congenital stationary night blindness (HP:0007642)2.30365553
52Absent thumb (HP:0009777)2.30122345
53Carpal bone hypoplasia (HP:0001498)2.29678375
54Chronic sinusitis (HP:0011109)2.29460642
55Glycosuria (HP:0003076)2.26768050
56Abnormality of urine glucose concentration (HP:0011016)2.26768050
57Abnormal rod and cone electroretinograms (HP:0008323)2.25666090
58Hypergammaglobulinemia (HP:0010702)2.24949865
59Redundant skin (HP:0001582)2.23587380
60B lymphocytopenia (HP:0010976)2.21457098
61Attenuation of retinal blood vessels (HP:0007843)2.20870786
62Bronchitis (HP:0012387)2.19683889
63Reticulocytopenia (HP:0001896)2.17431259
64Irregular vertebral endplates (HP:0003301)2.15204032
65Molar tooth sign on MRI (HP:0002419)2.14039547
66Abnormality of midbrain morphology (HP:0002418)2.14039547
67Respiratory failure (HP:0002878)2.13713904
68Short tibia (HP:0005736)2.06845328
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.05632513
70Partial duplication of thumb phalanx (HP:0009944)2.03927512
71Cerebral edema (HP:0002181)2.03881152
72Fibular hypoplasia (HP:0003038)2.03342863
73Encephalitis (HP:0002383)1.95754065
74Granulocytopenia (HP:0001913)1.95560945
75Delayed epiphyseal ossification (HP:0002663)1.93199809
76Autoimmune thrombocytopenia (HP:0001973)1.93066686
77Parakeratosis (HP:0001036)1.91033259
78Abnormality of B cell number (HP:0010975)1.90527041
79Gastrointestinal infarctions (HP:0005244)1.90415106
80Abolished electroretinogram (ERG) (HP:0000550)1.89755216
81CNS demyelination (HP:0007305)1.89592410
82Abnormality of macrophages (HP:0004311)1.88305834
83Leukocytosis (HP:0001974)1.86635789
84Exercise intolerance (HP:0003546)1.85189863
85Amniotic constriction ring (HP:0009775)1.83919473
86Abnormality of placental membranes (HP:0011409)1.83919473
87Abnormal drinking behavior (HP:0030082)1.83814447
88Polydipsia (HP:0001959)1.83814447
89Aortic aneurysm (HP:0004942)1.82975117
90Optic disc pallor (HP:0000543)1.81265421
91Short hallux (HP:0010109)1.81245268
92Abnormality of the vertebral endplates (HP:0005106)1.80626418
93Pulmonary artery stenosis (HP:0004415)1.80306033
94Aplasia/Hypoplasia of the fibula (HP:0006492)1.79137422
95Decreased central vision (HP:0007663)1.78563252
96IgM deficiency (HP:0002850)1.76059247
97Chronic diarrhea (HP:0002028)1.75389516
98Neoplasm of head and neck (HP:0012288)1.74709664
99Esophageal neoplasm (HP:0100751)1.74709664
100Cellular immunodeficiency (HP:0005374)1.73592475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.21346050
2TESK25.80955901
3MAP3K123.50533157
4TESK13.43903245
5LIMK13.13541731
6TXK2.96101176
7MUSK2.72203675
8MAP4K12.68762542
9TLK12.67732205
10MYLK2.59746927
11ZAK1.98191052
12BUB11.93375450
13NME11.89976639
14TAOK31.81885757
15BCKDK1.68445504
16ITK1.65395644
17ADRBK21.63672151
18CAMKK21.53624127
19WNK41.53129336
20GRK11.45486872
21FRK1.36242515
22TEC1.35976865
23NLK1.31229624
24MAP3K111.28244187
25PIK3CA1.28240052
26TYK21.11495340
27VRK21.09522701
28CLK11.08389017
29ZAP701.07129530
30VRK11.04413546
31MAP4K21.03636996
32ADRBK10.97196883
33ROCK10.93908075
34PRKCQ0.91267228
35NUAK10.90853101
36MAPKAPK30.90500840
37GRK70.85392579
38SYK0.84445390
39JAK30.80665485
40LRRK20.80557060
41PAK30.80232486
42IKBKE0.78630267
43LCK0.76746594
44PDGFRB0.73149254
45KIT0.67921463
46FES0.67026696
47DDR20.66937700
48CAMKK10.65888299
49PAK10.65334118
50OXSR10.64703154
51BRSK20.63631335
52TRPM70.62659942
53TNK20.62338007
54ILK0.62129170
55CSK0.60341546
56DAPK10.59459896
57SCYL20.59360831
58STK160.58301807
59STK390.58227611
60INSRR0.57524939
61ABL20.56368029
62RPS6KA50.55433911
63MAPK150.54995750
64MAP3K50.54928036
65LYN0.52755638
66OBSCN0.52657391
67BTK0.51770888
68IGF1R0.51290637
69PIK3CG0.50560547
70INSR0.49218467
71ERBB30.48590683
72NME20.44230515
73DAPK30.43918330
74AURKA0.43157733
75CDK190.42950496
76PRKCH0.42362820
77TBK10.42344575
78CSF1R0.41269615
79GRK60.40129261
80PIM10.40129206
81PAK20.39562316
82PRKCA0.39524206
83PRKG20.37871015
84TIE10.37664471
85PKN10.37322585
86BMPR20.37209593
87IKBKB0.37129659
88PLK40.36134617
89CAMK10.34196924
90MARK30.34060235
91ABL10.32852257
92EIF2AK30.32318998
93CHEK20.31255081
94MAP2K60.29769116
95BRSK10.29358767
96PRKD10.29015699
97PINK10.28879391
98PASK0.28772702
99PRKACA0.26656803
100PRKCD0.26542677

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.91401562
2Oxidative phosphorylation_Homo sapiens_hsa001904.51936337
3Primary immunodeficiency_Homo sapiens_hsa053404.18410544
4Parkinsons disease_Homo sapiens_hsa050123.84997261
5Ribosome_Homo sapiens_hsa030103.65397358
6Alzheimers disease_Homo sapiens_hsa050102.84511565
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.60013142
8Huntingtons disease_Homo sapiens_hsa050162.40014448
9Antigen processing and presentation_Homo sapiens_hsa046122.19022547
10Cardiac muscle contraction_Homo sapiens_hsa042602.15529509
11Protein export_Homo sapiens_hsa030602.11506789
12Hematopoietic cell lineage_Homo sapiens_hsa046401.96191245
13Graft-versus-host disease_Homo sapiens_hsa053321.95310812
14Mineral absorption_Homo sapiens_hsa049781.94267051
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93866853
16RNA polymerase_Homo sapiens_hsa030201.89899848
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77729913
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72772933
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62506655
20Allograft rejection_Homo sapiens_hsa053301.45269177
21Autoimmune thyroid disease_Homo sapiens_hsa053201.44995503
22T cell receptor signaling pathway_Homo sapiens_hsa046601.32091192
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28787289
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21190573
25Peroxisome_Homo sapiens_hsa041461.19337089
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.17825754
27Chemical carcinogenesis_Homo sapiens_hsa052041.16647656
28ABC transporters_Homo sapiens_hsa020101.12910044
29Malaria_Homo sapiens_hsa051441.12829594
30Homologous recombination_Homo sapiens_hsa034401.04413249
31Type I diabetes mellitus_Homo sapiens_hsa049401.03923205
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03266599
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03163325
34Measles_Homo sapiens_hsa051621.00600707
35Sulfur metabolism_Homo sapiens_hsa009200.95028949
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93459098
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92882557
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92591554
39Phototransduction_Homo sapiens_hsa047440.92355442
40One carbon pool by folate_Homo sapiens_hsa006700.89323335
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87932595
42Rheumatoid arthritis_Homo sapiens_hsa053230.83542901
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82491459
44DNA replication_Homo sapiens_hsa030300.78760564
45Fanconi anemia pathway_Homo sapiens_hsa034600.78291517
46Pyrimidine metabolism_Homo sapiens_hsa002400.76593476
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72587175
48Shigellosis_Homo sapiens_hsa051310.69820451
49Glutathione metabolism_Homo sapiens_hsa004800.69449144
50Retinol metabolism_Homo sapiens_hsa008300.67466751
51Systemic lupus erythematosus_Homo sapiens_hsa053220.64653771
52Nitrogen metabolism_Homo sapiens_hsa009100.64512566
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.63269181
54Nucleotide excision repair_Homo sapiens_hsa034200.63144874
55Fatty acid elongation_Homo sapiens_hsa000620.62718898
56Caffeine metabolism_Homo sapiens_hsa002320.62402343
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62388947
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62063952
59Propanoate metabolism_Homo sapiens_hsa006400.58658896
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.58385809
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56409882
62Butanoate metabolism_Homo sapiens_hsa006500.56004599
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55851746
64Linoleic acid metabolism_Homo sapiens_hsa005910.55771113
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55027738
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.54353055
67ECM-receptor interaction_Homo sapiens_hsa045120.53049487
68Viral myocarditis_Homo sapiens_hsa054160.52367286
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50512592
70Olfactory transduction_Homo sapiens_hsa047400.49018975
71Salmonella infection_Homo sapiens_hsa051320.48774626
72PPAR signaling pathway_Homo sapiens_hsa033200.47337778
73Pertussis_Homo sapiens_hsa051330.47056357
74Metabolic pathways_Homo sapiens_hsa011000.46275158
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46166102
76Tyrosine metabolism_Homo sapiens_hsa003500.44569010
77Purine metabolism_Homo sapiens_hsa002300.43565151
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43331001
79Mismatch repair_Homo sapiens_hsa034300.40937125
80Taste transduction_Homo sapiens_hsa047420.40625005
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39683433
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39039168
83Collecting duct acid secretion_Homo sapiens_hsa049660.37681127
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35963139
85Staphylococcus aureus infection_Homo sapiens_hsa051500.35312275
86Basal transcription factors_Homo sapiens_hsa030220.34457676
87Fatty acid biosynthesis_Homo sapiens_hsa000610.33741370
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32542477
89Sulfur relay system_Homo sapiens_hsa041220.30546586
90Arachidonic acid metabolism_Homo sapiens_hsa005900.30219596
91Fatty acid degradation_Homo sapiens_hsa000710.29734807
92Tryptophan metabolism_Homo sapiens_hsa003800.27201275
93Histidine metabolism_Homo sapiens_hsa003400.26845638
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26236993
95Selenocompound metabolism_Homo sapiens_hsa004500.25370589
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24103982
97Dilated cardiomyopathy_Homo sapiens_hsa054140.23376636
98Ovarian steroidogenesis_Homo sapiens_hsa049130.23296222
99Steroid biosynthesis_Homo sapiens_hsa001000.20982154
100Glycerolipid metabolism_Homo sapiens_hsa005610.20393006

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